text
stringlengths 57
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| relation
stringclasses 125
values | h
dict | t
dict |
|---|---|---|---|
death from aortic injuries is most commonly caused by hemorrhage and exsanguination , so appropriate measures must be taken as soon as the diagnosis is made to avoid this possibility . | NA | {
"id": "C0019080",
"name": "hemorrhage",
"pos": [
54,
64
]
} | {
"id": "C0232100",
"name": "exsanguination",
"pos": [
69,
83
]
} |
striking differences in the proportion of the individual disaccharidases were found inthe jejunum and ileum of c rabbits compared with gf rabbits , in which , in both these segments of small intestine the relationship maltase greater than sucrase greater than trehalase greater than lactase was preserved . | NA | {
"id": "C0012610",
"name": "disaccharidases",
"pos": [
57,
72
]
} | {
"id": "C0038634",
"name": "sucrase",
"pos": [
239,
246
]
} |
striking differences in the proportion of the individual disaccharidases were found inthe jejunum and ileum of c rabbits compared with gf rabbits , in which , in both these segments of small intestine the relationship maltase greater than sucrase greater than trehalase greater than lactase was preserved . | NA | {
"id": "C0012610",
"name": "disaccharidases",
"pos": [
57,
72
]
} | {
"id": "C0040814",
"name": "trehalase",
"pos": [
260,
269
]
} |
evaluation of the serum alkaline phosphatase isoenzymes significantly enhances the efficiency of the diagnosis and the organ specificity of the enzymes in these conditions . | NA | {
"id": "C0022173",
"name": "isoenzymes",
"pos": [
45,
55
]
} | {
"id": "C0014442",
"name": "enzymes",
"pos": [
144,
151
]
} |
acetone does thus not appear to play a preminent role in the isopropanol induced fatty liver which seems to be related mainly to a direct action of the alcohol itself . | NA | {
"id": "C0022237",
"name": "isopropanol",
"pos": [
61,
72
]
} | {
"id": "C0001962",
"name": "alcohol",
"pos": [
152,
159
]
} |
the cells forming solid clusters without follicles were indistinguishable from the precursor cells of the parafollicular cells . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
4,
9
]
} | {
"id": "C0018956",
"name": "precursor cells",
"pos": [
83,
98
]
} |
in addition to adrenaline-storing ( a ) cells and noradrenaline-storing ( na ) cells , a third calss of chromaffin cells is distinguishable . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
15,
25
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
50,
63
]
} |
adrenaline storing ( a ) cells were found to be filled with slightly irregular , larger electron-dense granules , whereas noradrenaline-storing ( na ) cells contained smaller granules with an electron-dense content . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
0,
10
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
122,
135
]
} |
atenolol ( 100-200 mg ) administered once or twice daily produced a significant reduction of arterial pressure and a smaller response to the cold pressor test , hand grip and step test in patients with established hypertension , but little change in those with labile hypertension . | NA | {
"id": "C0020538",
"name": "hypertension",
"pos": [
214,
226
]
} | {
"id": "C0262534",
"name": "labile",
"pos": [
261,
267
]
} |
the csf and sera of 17 patients with meningoencephalitis or encephalitis , 10 with meningitis or meningomyelitis , 5 subjects with postencephalitic sequelae and 2 with arachnoiditis were studied . | NA | {
"id": "C0025289",
"name": "meningitis",
"pos": [
83,
93
]
} | {
"id": "C0003708",
"name": "arachnoiditis",
"pos": [
168,
181
]
} |
the results indicated that human gastric agag consisted of , in the order of amount , heparan sulfates , dermatan sulfate , hyaluronic acid , chondroitin-4-sulfate , chondroitin-6-sulfate and presumably oversulfated chondroitin sulfate . | NA | {
"id": "C0017973",
"name": "agag",
"pos": [
41,
45
]
} | {
"id": "C0019143",
"name": "heparan sulfates",
"pos": [
86,
102
]
} |
131i-albumin studies showed no significant change of albumin degradation and , by inference , of intestinal protein loss in the group as a whole . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
5,
12
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
108,
115
]
} |
it is postulated that a single pathological process-hyperplasia , perhaps related to the anabolic effect of methyltestosterone -- could be partly responsible both for the formation of cysts through mechanical obstruction of hepatic veins and for the formation of nodules and tumours . | NA | {
"id": "C0030660",
"name": "pathological process",
"pos": [
31,
51
]
} | {
"id": "C0020507",
"name": "hyperplasia",
"pos": [
52,
63
]
} |
hemoglobin adsorption to foreign surfaces has not previously been considered in studies of blood-material interactions , despite the fact that hemoglobin is the most abundant protein present in blood . | NA | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
0,
10
]
} | {
"id": "C0005832",
"name": "protein",
"pos": [
175,
182
]
} |
the model predicts the probability of fracture for patients of different body weight , and the incidence of fractures versus body weight , and versus time . | NA | {
"id": "C0005911",
"name": "different body weight",
"pos": [
63,
84
]
} | {
"id": "C0005910",
"name": "body weight",
"pos": [
125,
136
]
} |
the decrease in the attenuation of the hematoma from the time of trauma or bleeding was studied . | NA | {
"id": "C0018944",
"name": "hematoma",
"pos": [
39,
47
]
} | {
"id": "C0019080",
"name": "bleeding",
"pos": [
75,
83
]
} |
parotid saliva f concentration and urinary f excretion were highest with naf , na2po3f , and snf2 , lowest with caf2 , and intermediate with alf3 . | NA | {
"id": "C0016327",
"name": "f",
"pos": [
15,
16
]
} | {
"id": "C0037508",
"name": "naf",
"pos": [
73,
76
]
} |
the product of this activity is a series of guanidino acids which are methyl receptors converting s-adenosylmethionine to adenosine and homocysteine . | NA | {
"id": "C0036002",
"name": "s-adenosylmethionine",
"pos": [
98,
118
]
} | {
"id": "C0001443",
"name": "adenosine",
"pos": [
122,
131
]
} |
in twenty-one of the subjects the urinary concentration of both beta 2-microglobulin and albumin were increased , in sixteen of these cases the relationship between the two proteins was consistent with tubular proteinuria . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
89,
96
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
173,
181
]
} |
effect of storage conditions of serum lipoproteins on electrophoretic mobility in agarose gel and on lipid composition . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
38,
50
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
101,
106
]
} |
the actions of exogenous corticotrophin ( acth ) and human choriogonadotrophin ( hcg ) were assessed by measuring cyclic adenosine 3',5'-monophosphate ( camp ) , 17-ketosteroids ( 17-ks ) , 17-ketogenic steroids ( 17-kgs ) , androsterone ( a ) , etiocholanolone ( e ) , dehydroepiandrosterone ( dhea ) and pregnanetriol ( p3 ) in 24 h urine . | NA | {
"id": "C0000167",
"name": "17-ketosteroids",
"pos": [
162,
177
]
} | {
"id": "C0002865",
"name": "androsterone",
"pos": [
280,
292
]
} |
the actions of exogenous corticotrophin ( acth ) and human choriogonadotrophin ( hcg ) were assessed by measuring cyclic adenosine 3',5'-monophosphate ( camp ) , 17-ketosteroids ( 17-ks ) , 17-ketogenic steroids ( 17-kgs ) , androsterone ( a ) , etiocholanolone ( e ) , dehydroepiandrosterone ( dhea ) and pregnanetriol ( p3 ) in 24 h urine . | NA | {
"id": "C0000167",
"name": "17-ketosteroids",
"pos": [
162,
177
]
} | {
"id": "C0015124",
"name": "etiocholanolone",
"pos": [
246,
261
]
} |
transcapillary escape rates of albumin and igg ( fractions of intravascular mass of albumin and igg that pass to the extravascular space per unit time ) were determined simultaneously from the initial disappearance of intravenously injected 131i human albumin and 125i human igg in seven untreated subjects suffering from essential hypertension . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
31,
38
]
} | {
"id": "C0304925",
"name": "human albumin",
"pos": [
246,
259
]
} |
based on this material it is proposed that chronic immunostimulation in the recipient caused by graft antigens and bacteria and virus antigens puts a stop to t-suppressor lymphocyte function and subsequent proliferation of the lymphoid tissue , and that this is a major factor in the appearance of tumours derived from mesenchymal tissue , whereas the occurrence of ectodermal tumours is a result of a series of other oncogenetic factors . | NA | {
"id": "C0003320",
"name": "antigens",
"pos": [
102,
110
]
} | {
"id": "C0003342",
"name": "virus antigens",
"pos": [
128,
142
]
} |
control subjects and patients with liver diseases ( cirrhosis , fatty liver ) were given an oral methionine load with 100 mg l-met/kg body weight . | NA | {
"id": "C0023895",
"name": "liver diseases",
"pos": [
35,
49
]
} | {
"id": "C0023890",
"name": "cirrhosis",
"pos": [
52,
61
]
} |
control subjects and patients with liver diseases ( cirrhosis , fatty liver ) were given an oral methionine load with 100 mg l-met/kg body weight . | NA | {
"id": "C0023895",
"name": "liver diseases",
"pos": [
35,
49
]
} | {
"id": "C0015695",
"name": "fatty liver",
"pos": [
64,
75
]
} |
the biosynthesis occurs via proinsulin and is also in most respects similar to mammalian insulin biosynthesis . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
28,
38
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
89,
96
]
} |
although the conversion of proinsulin to insulin seems to occur in the secretion granules , they contain no crystalline cores . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
27,
37
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
41,
48
]
} |
isomers and epimers of glucose influence insulin and camp in a parallel fashion as do sulfonylurea compounds ( tolbutamide and glibenclamide ) . | NA | {
"id": "C0038766",
"name": "sulfonylurea compounds",
"pos": [
86,
108
]
} | {
"id": "C0017628",
"name": "glibenclamide",
"pos": [
127,
140
]
} |
the results indicate that metabolism of camp in the beta-cell is intimately linked to the glucose ( and sulfonylurea ) action on insulin secretion , although other factors influenced by the hexose are also necessary for the release process . | NA | {
"id": "C0017725",
"name": "glucose",
"pos": [
90,
97
]
} | {
"id": "C0019494",
"name": "hexose",
"pos": [
190,
196
]
} |
circulatory support and early cardiac surgery in the management of cardiogenic shock complicating myocardial infarction . | NA | {
"id": "C0036980",
"name": "cardiogenic",
"pos": [
67,
78
]
} | {
"id": "C0027051",
"name": "myocardial infarction",
"pos": [
98,
119
]
} |
about a 10-fold variation was found during the first 6 hours after the drug in individual serum medazepam , diazepam , and n-desmethyldiazepam levels . | NA | {
"id": "C0012010",
"name": "diazepam",
"pos": [
108,
116
]
} | {
"id": "C0011279",
"name": "desmethyldiazepam",
"pos": [
125,
142
]
} |
after 14 days ' treatment serum n-desmethyldiazepam levels were generally above 800 ng/ml , 7 to 8 times higher than the serum medazepam or diazepam levels measured 12 hours after the last dose . | NA | {
"id": "C0011279",
"name": "desmethyldiazepam",
"pos": [
34,
51
]
} | {
"id": "C0012010",
"name": "diazepam",
"pos": [
140,
148
]
} |
the plasma noradrenaline rose more than twofold after 10 min in the hot room ( 100 degrees c ) while the plasma adrenaline content exhibited smaller increases . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
11,
24
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
112,
122
]
} |
the plasma noradrenaline concentration remained elevated or further increased after 5 min in a cool swimming pool ( 22 degrees c ) whereas the exposure to cool water restored the plasma adrenaline concentration to resting values . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
11,
24
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
186,
196
]
} |
plasma noradrenaline , but not adrenaline , was still markedly elevated after a rest period of 15 min after the cool pool . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
7,
20
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
31,
41
]
} |
effect of calcium p-chlorphenoxyisobutyrate and calcium carbonate on plasma lipids and lipoproteins of patients with hyperlipoproteinaemia . | NA | {
"id": "C0006675",
"name": "calcium",
"pos": [
10,
17
]
} | {
"id": "C0006681",
"name": "calcium carbonate",
"pos": [
48,
65
]
} |
six out of the 9 cases of tracheomalacia and all the 5 cases of bronchomalacia had developed into tracheobronchomalacia . | NA | {
"id": "C0948187",
"name": "tracheomalacia",
"pos": [
26,
40
]
} | {
"id": "C0340231",
"name": "tracheobronchomalacia",
"pos": [
98,
119
]
} |
six out of the 9 cases of tracheomalacia and all the 5 cases of bronchomalacia had developed into tracheobronchomalacia . | NA | {
"id": "C0264353",
"name": "bronchomalacia",
"pos": [
64,
78
]
} | {
"id": "C0340231",
"name": "tracheobronchomalacia",
"pos": [
98,
119
]
} |
they have seen that some lipids fractions , as triglycerides , waxes and squalenes explicate an action that favours the penetration of the cercariae in vitro on a plate of agar and that such an action is due to the unsaturation in the above said fractions of sebaceous origin . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
25,
31
]
} | {
"id": "C0043076",
"name": "waxes",
"pos": [
63,
68
]
} |
sice 17.26 % of our studied subjects showed hemolytic antibodies , we consider it is sufficient to identify dangerous donors through a dosage of hemolytic isoantibodies . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
54,
64
]
} | {
"id": "C0022144",
"name": "isoantibodies",
"pos": [
155,
168
]
} |
their absolute values as well as their percentages relative to total aminoacids of the blood were markedly increased in all tumor patients tested , as well as in experimental tumor rats . | NA | {
"id": "C0027651",
"name": "tumor",
"pos": [
124,
129
]
} | {
"id": "C0027659",
"name": "experimental",
"pos": [
162,
174
]
} |
in a boxer dog aged 12 years who had deceased from circulatory insufficiency due to purulent endomyocarditis , there occurred a leydig cell adenoma of the testis and multiple cutaneous naevi ( haemangioma , pigmented naevus and various cutanous organ naevi ) . | NA | {
"id": "C0027962",
"name": "pigmented naevus",
"pos": [
207,
223
]
} | {
"id": "C0027960",
"name": "naevi",
"pos": [
251,
256
]
} |
the serine peptidase has been purified by two methods , permitting a comparison of the detergent-released and proteinase-released forms . | NA | {
"id": "C0036734",
"name": "serine peptidase",
"pos": [
4,
20
]
} | {
"id": "C0030946",
"name": "proteinase",
"pos": [
110,
120
]
} |
the biological cycle of phosphorus differs from that of other bulk elements in so far that the complete cycle has a long half-life . | NA | {
"id": "C0031705",
"name": "phosphorus",
"pos": [
24,
34
]
} | {
"id": "C0013879",
"name": "elements",
"pos": [
67,
75
]
} |
as this element appears to have no redox reactions in biological systems phosphorus is always handled as phosphate and , as all phosphate compounds are thermodynamically unstable in water , phosphate uptake and incorporation are associated with energy consumption . | NA | {
"id": "C0013879",
"name": "element",
"pos": [
8,
15
]
} | {
"id": "C0031705",
"name": "phosphorus",
"pos": [
73,
83
]
} |
combination effect of antitumor agents , including doxorubicin and daunorubicin , was evaluated on the concept of pharmacological synergism in ascites sarcoma-180 system . | NA | {
"id": "C0013089",
"name": "doxorubicin",
"pos": [
51,
62
]
} | {
"id": "C0011015",
"name": "daunorubicin",
"pos": [
67,
79
]
} |
combination effect of agents was affected by the schedule of drug administration for doxorubicin , but weak for daunorubicin . | NA | {
"id": "C0013089",
"name": "doxorubicin",
"pos": [
85,
96
]
} | {
"id": "C0011015",
"name": "daunorubicin",
"pos": [
112,
124
]
} |
toxicity of doxorubicin or daunorubicin in combination with other drugs was also affected by the schedule of administration . | NA | {
"id": "C0013089",
"name": "doxorubicin",
"pos": [
12,
23
]
} | {
"id": "C0011015",
"name": "daunorubicin",
"pos": [
27,
39
]
} |
lets glycoprotein is a surface glycoprotein which is absent or greatly diminished on the surfaces of transformed cells . | NA | {
"id": "C0017968",
"name": "glycoprotein",
"pos": [
5,
17
]
} | {
"id": "C0025248",
"name": "surface glycoprotein",
"pos": [
23,
43
]
} |
six patients were on drug combination including two or more of the following : phenytoin , phenobarbital , primidone , carbamazepine , diazepam , ethosuximide . | NA | {
"id": "C0031412",
"name": "phenobarbital",
"pos": [
91,
104
]
} | {
"id": "C0033148",
"name": "primidone",
"pos": [
107,
116
]
} |
48 patients with several types of seizures ( following the international classification of epileptic seizures ) , were studied . | NA | {
"id": "C0036572",
"name": "seizures",
"pos": [
34,
42
]
} | {
"id": "C0014544",
"name": "epileptic seizures",
"pos": [
91,
109
]
} |
however , the more marked degrees of atrophy were found among patients with long-standing or poorly controlled epilepsy , an observation which has important implications with regard to the adequacy of seizure control in epileptic patients . | NA | {
"id": "C0036572",
"name": "seizure",
"pos": [
201,
208
]
} | {
"id": "C0014544",
"name": "epileptic",
"pos": [
220,
229
]
} |
the human interferons certainly differ in their extent of glycosylation and hydrophobicity , and may have different amino-acid sequences , since it has recently been reported that when the messenger rnas extracted from fibroblast and lymphoblastoid cells are translated in xenopus oocytes , the products are antigenically distinguishable ( 26,29,40 ) . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
219,
229
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
249,
254
]
} |
priming by mouse fibroblast interferon , mouse immune interferon , and human leukocyte interferon was directly related to the plaque reduction titer of each of the interferons on l cells . | NA | {
"id": "C0021745",
"name": "immune interferon",
"pos": [
47,
64
]
} | {
"id": "C0021747",
"name": "interferons",
"pos": [
164,
175
]
} |
interferon induced by antigen or mitogen ( immune interferon ) primarily in t lymphocytes also appears capable of suppressing the antibody response . | NA | {
"id": "C0021747",
"name": "interferon",
"pos": [
0,
10
]
} | {
"id": "C0021745",
"name": "immune interferon",
"pos": [
43,
60
]
} |
the production of interferon was employed to study the site and mechanism of action of retinoic acid ( vitamin a ) . | NA | {
"id": "C0040845",
"name": "retinoic acid",
"pos": [
87,
100
]
} | {
"id": "C0042839",
"name": "vitamin a",
"pos": [
103,
112
]
} |
the acetylcholine content was 4.35 -- 4.36 mg/g of desiccated venom as shown by two different biological assay methods , and the index of discrimination was found to be 1.1 , further confirming that substance in snake venom was acetylcholine . | NA | {
"id": "C0042479",
"name": "venom",
"pos": [
62,
67
]
} | {
"id": "C0037380",
"name": "snake venom",
"pos": [
212,
223
]
} |
cathepsin b and collagenolytic cathepsin were obtained from bovine spleen and human placenta and identified as thiol proteinases . | NA | {
"id": "C0007428",
"name": "cathepsin",
"pos": [
0,
9
]
} | {
"id": "C0030940",
"name": "proteinases",
"pos": [
117,
128
]
} |
from the decay which appears to follow first order kinetics a half-life of 9 min was found for the compartment of autophagic vacuoles . | NA | {
"id": "C0022702",
"name": "kinetics",
"pos": [
51,
59
]
} | {
"id": "C0018517",
"name": "half-life",
"pos": [
62,
71
]
} |
the proteinases of group 1 are characterized by both trypsin-like and carboxypeptidase b-like specificities with slightly acid ph optima ( ph 5.5-6.5 ) and seem to play important roles in the conversion of proinsulin into insulin . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
206,
216
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
222,
229
]
} |
the metabolic clearance rates ( mcr ) of insulin , proinsulin and chemically modified insulins have been measured by a priming-dose constant infusion technique in greyhounds . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
41,
48
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
51,
61
]
} |
conversion of proinsulin and intermediate forms of proinsulin into insulin were studied with rat liver cell fractions and purified lysosomal proteinases by using the technique of polyacrylamide disc-electrophoresis . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
14,
24
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
67,
74
]
} |
with partially purified lysosomal fractions ( mol . wt . approx . 25 000 ) or with highly purified cathepsin l or cathepsin b ( b1 ) proinsulin was converted into products migrating like the intermediate forms and insulin , and the intermediates were converted into products migrating like insulin and deoctapeptide-insulin in disc-electropherograms . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
133,
143
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
316,
323
]
} |
the results force us to conclude that lysosomal cathepsins , especially cathepsins l and b might be involved in the process of conversion of proinsulin into insulin and perhaps also of other precursors into biologically active proteins in vivo . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
141,
151
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
157,
164
]
} |
short-lived cytosolic proteins were especially suited as substrate for neutral proteases from all other fractions , but also microsomal , mitochondrial and nuclear proteins were well degraded by foreign fractions in comparison with the substrate autoproteolysis . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
22,
30
]
} | {
"id": "C0028589",
"name": "nuclear proteins",
"pos": [
156,
172
]
} |
psychiatric problems are often overlooked as manifestations of digitalis excess and may range from mild disorientation , lethargy , or restlessness to full blown delirium . | NA | {
"id": "C0009676",
"name": "disorientation",
"pos": [
104,
118
]
} | {
"id": "C0011206",
"name": "delirium",
"pos": [
162,
170
]
} |
[ reduction of organic compounds with thiourea dioxide . ii . reduction of aromatic nitro compounds and syntheses of hydrazo compounds ( author 's transl ) ] . | NA | {
"id": "C0029224",
"name": "organic compounds",
"pos": [
15,
32
]
} | {
"id": "C0028138",
"name": "nitro compounds",
"pos": [
84,
99
]
} |
the hsv-induced dna-dependent dna polymerase was 39-fold more sensitive to ara-atp than was cellular dna polymerase-beta and 116-fold more sensitive than cellular dna polymerase-alpha . | NA | {
"id": "C0012892",
"name": "dna-dependent dna polymerase",
"pos": [
16,
44
]
} | {
"id": "C0525039",
"name": "dna polymerase-beta",
"pos": [
101,
120
]
} |
in herpesvirus- ( strain lennette ) -infected cells , however , ara-a shows no influence on the incorporation on deoxythymidine into cellular dna , but it substantially reduces the incorporation into viral dna . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
142,
145
]
} | {
"id": "C0012939",
"name": "viral",
"pos": [
200,
205
]
} |
serotonin and its precursors , tryptophan and 5-hydroxytryptophan , are powerful releasors of prolactin and have been shown to be involved in some physiological states in which prolactin is released , i.e . during suckling , stress , etc . | NA | {
"id": "C0041249",
"name": "tryptophan",
"pos": [
31,
41
]
} | {
"id": "C0000578",
"name": "5-hydroxytryptophan",
"pos": [
46,
65
]
} |
a long-term evaluation of very low calorie semi-synthetic diets : an inpatient/outpatient study with egg albumin as the protein source . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
105,
112
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
120,
127
]
} |
thus , the patients demonstrated a characteristic three phase pattern in weight change with a period of reduction followed by periods of steady weight and of weight gain . | NA | {
"id": "C0005911",
"name": "in weight change",
"pos": [
70,
86
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
158,
164
]
} |
thus , the patients demonstrated a characteristic three phase pattern in weight change with a period of reduction followed by periods of steady weight and of weight gain . | NA | {
"id": "C0005911",
"name": "in weight change",
"pos": [
70,
86
]
} | {
"id": "C0043094",
"name": "weight gain",
"pos": [
158,
169
]
} |
[ pharmacodynamics of digitalis glycoside in childhood . comparative study of the bioavailability of digoxin and beta methyldigoxin ] . | NA | {
"id": "C0012253",
"name": "digitalis glycoside",
"pos": [
22,
41
]
} | {
"id": "C0012265",
"name": "digoxin",
"pos": [
124,
131
]
} |
[ pharmacodynamics of digitalis glycoside in childhood . comparative study of the bioavailability of digoxin and beta methyldigoxin ] . | NA | {
"id": "C0012265",
"name": "digoxin",
"pos": [
101,
108
]
} | {
"id": "C0025132",
"name": "beta methyldigoxin",
"pos": [
113,
131
]
} |
one-hundred-and-fifty overweight patients , who were given advice about losing weight during a period of eight years in a suburban general practice of 2000 individuals in the british national health service , have been followed up for a minimum of 10 years . | NA | {
"id": "C0497406",
"name": "overweight",
"pos": [
22,
32
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
79,
85
]
} |
the consequences of early overnutrition for fat cell size and number : the pig as an experimental model for human obesity . | NA | {
"id": "C1257763",
"name": "overnutrition",
"pos": [
26,
39
]
} | {
"id": "C0028754",
"name": "obesity",
"pos": [
114,
121
]
} |
insulin levels at the moment of glucose-induced reactive hypoglycemia have been compared with zero-hour insulin levels in 108 subjects in whom the blood glucose had decreased to 50 mg percent or less ( 50 to 31 mg ) at the third , fourth , or fifth hour in the course of an oral glucose tolerance test ( 1.75 g/kg of body weight ) . | NA | {
"id": "C0017725",
"name": "glucose",
"pos": [
32,
39
]
} | {
"id": "C0005802",
"name": "blood",
"pos": [
147,
152
]
} |
the most striking finding was that , while gonadectomy only modestly augmented the weight gain following vmh lesions in females , castrated vmh males gained twice as much weight as gonadally intact vmh males . | NA | {
"id": "C0037088",
"name": "finding",
"pos": [
18,
25
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
171,
177
]
} |
after a decrease of body weight by 11 per cent this ratio did not change significantly ( 4 ) a negative correlation between the glucose/insulin ratio and body weight , overweight , body fat and lean body mass . | NA | {
"id": "C0005910",
"name": "body weight",
"pos": [
20,
31
]
} | {
"id": "C0497406",
"name": "overweight",
"pos": [
168,
178
]
} |
modification of early and late plasma amino acid profiles in hemorrhagic shock by glucose and alanine treatment . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
38,
48
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
94,
101
]
} |
the role of pituitary vasopressin ( antidiuretic hormone -- adh ) in the formation and dynamics of aqueous humour was studied in rabbits employing different techniques . | NA | {
"id": "C0003779",
"name": "vasopressin",
"pos": [
22,
33
]
} | {
"id": "C0042413",
"name": "antidiuretic hormone",
"pos": [
36,
56
]
} |
cerebellar changes have been reported in relationship to epilepsy alone as well as to phenytoin therapy for the control of seizures . | NA | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
57,
65
]
} | {
"id": "C0036572",
"name": "seizures",
"pos": [
123,
131
]
} |
the rough lps was shown to contain lipid a , heptose , 2-keto 3-deoxyoctonic acid , galactosamine , alanine and phosphate but lacked glucose , rhamnose and fucosamine which were important constituents , on a weight basis , of the smooth lps . | NA | {
"id": "C0023767",
"name": "lipid a",
"pos": [
35,
42
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
237,
240
]
} |
analysis of plasma samples from patients with myocardial infarction , cirrhosis of the liver malignant diseases and dic confirmed the presence of considerable amounts of fibrin monomer revealing concentrations between 3 and 15 mg/100 m1 plasma as compared to normal plasma ( 1.96 +/- 0.37 mg/100 m1 , = 27 ) . | NA | {
"id": "C0023890",
"name": "cirrhosis",
"pos": [
70,
79
]
} | {
"id": "C0023895",
"name": "of the liver",
"pos": [
80,
92
]
} |
the remaining clotting factors fell in a dose-dependent fashion but there was a tendency toward recovery despite continued infusion of thromboplastin . | NA | {
"id": "C0005789",
"name": "clotting factors",
"pos": [
14,
30
]
} | {
"id": "C0040048",
"name": "thromboplastin",
"pos": [
135,
149
]
} |
( 1 ) factor ix concentrate contained the coagulation factors as prothrombin complex ( factors ii , vii , ix and x ) ; | NA | {
"id": "C0005789",
"name": "coagulation factors",
"pos": [
42,
61
]
} | {
"id": "C0033706",
"name": "factors ii",
"pos": [
87,
97
]
} |
( 1 ) factor ix concentrate contained the coagulation factors as prothrombin complex ( factors ii , vii , ix and x ) ; | NA | {
"id": "C0005789",
"name": "coagulation factors",
"pos": [
42,
61
]
} | {
"id": "C0015491",
"name": "ix",
"pos": [
106,
108
]
} |
the inhibitory effect of slime seemed to be , at least in part , due to an inherent peptidase ( protease ) activity . | NA | {
"id": "C0030940",
"name": "peptidase",
"pos": [
84,
93
]
} | {
"id": "C0030946",
"name": "protease",
"pos": [
96,
104
]
} |
the potent in vitro activity of auranofin appears to result from its unique gold complex , since neither structurally related nongold compounds nor clinically used gold compounds ( gold sodium thiomalate and gold thioglucose ) were potent inhibitors of lysosomal enzyme release . | NA | {
"id": "C0004320",
"name": "auranofin",
"pos": [
32,
41
]
} | {
"id": "C0018026",
"name": "gold",
"pos": [
208,
212
]
} |
the potent in vitro activity of auranofin appears to result from its unique gold complex , since neither structurally related nongold compounds nor clinically used gold compounds ( gold sodium thiomalate and gold thioglucose ) were potent inhibitors of lysosomal enzyme release . | NA | {
"id": "C0004320",
"name": "auranofin",
"pos": [
32,
41
]
} | {
"id": "C0018033",
"name": "gold thioglucose",
"pos": [
208,
224
]
} |
the potent in vitro activity of auranofin appears to result from its unique gold complex , since neither structurally related nongold compounds nor clinically used gold compounds ( gold sodium thiomalate and gold thioglucose ) were potent inhibitors of lysosomal enzyme release . | NA | {
"id": "C0018026",
"name": "gold",
"pos": [
76,
80
]
} | {
"id": "C0018034",
"name": "gold sodium thiomalate",
"pos": [
181,
203
]
} |
the potent in vitro activity of auranofin appears to result from its unique gold complex , since neither structurally related nongold compounds nor clinically used gold compounds ( gold sodium thiomalate and gold thioglucose ) were potent inhibitors of lysosomal enzyme release . | NA | {
"id": "C0018026",
"name": "gold",
"pos": [
76,
80
]
} | {
"id": "C0018033",
"name": "gold thioglucose",
"pos": [
208,
224
]
} |
in contrast , gold sodium thiosulfate ( gst , an injectable gold compound ) had no inhibitory activity on ler at equivalent gold concentrations ( i.e. , 1 microg au/ml ) and only modest activity ( less than 36 % inhibition ) at concentrations as high as 40 microg au/ml . | NA | {
"id": "C0037512",
"name": "gold sodium thiosulfate",
"pos": [
14,
37
]
} | {
"id": "C0206108",
"name": "gold compound",
"pos": [
60,
73
]
} |
blood gold levels in auranofin-treated ra patients were found to be within the range required for in vitro inhibition of ler , and correlated with decreases in igg , rf titers , and igg-rf immune-complex formation in vitro . | NA | {
"id": "C0018026",
"name": "gold",
"pos": [
6,
10
]
} | {
"id": "C0004320",
"name": "auranofin",
"pos": [
21,
30
]
} |
human leukocyte extracts , egg white lysozyme , cationic proteins , polymyxin , colimycin , and phenol are capable of releasing lipoteichoic acids ( lta ) from group a streptococci and strep . mutans . | NA | {
"id": "C0032539",
"name": "polymyxin",
"pos": [
68,
77
]
} | {
"id": "C0009316",
"name": "colimycin",
"pos": [
80,
89
]
} |
the results obtained in patients with known primary hyperparathyroidism and in patients with unconfirmed but presumptive hyperparathyroidism are compared to the results obtained from a group of normal controls . | NA | {
"id": "C0221002",
"name": "primary hyperparathyroidism",
"pos": [
44,
71
]
} | {
"id": "C0020502",
"name": "hyperparathyroidism",
"pos": [
121,
140
]
} |
the causal role assigned to the e and f prostaglandins in inflammatory processes , implied by the antiinflammatory action of prostaglandin synthetase inhibitors , is not consistent with the findings reported here that a compound ( mk-447 ) capable of increasing levels of these prostaglandins is antiinflammatory in classical animal models of acute inflammation . | NA | {
"id": "C0033561",
"name": "f prostaglandins",
"pos": [
38,
54
]
} | {
"id": "C0033554",
"name": "prostaglandins",
"pos": [
278,
292
]
} |
of 47 children with an initial diagnosis of lymphosarcoma , reticulosarcoma or non-hodgkin 's lymphoma ( nhl ) , 13 had to be excluded at the histologic reevaluation : in 10 an undifferentiated sarcoma , in 2 hodgkin lymphoma was found ; | NA | {
"id": "C0024299",
"name": "lymphosarcoma",
"pos": [
44,
57
]
} | {
"id": "C0024305",
"name": "nhl",
"pos": [
105,
108
]
} |
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