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a speculative sequence of events is suggested by which neuronally-contained aluminosilicates might cleave or otherwise alter a normal cellular protein in such a manner that aggregates would arise that could interfere with cellular function and which also could act in a pseudo-infective manner , relaxing translational and transcriptional controls in the synthesis of the native protein . | process_includes_biological_process | {
"id": "C1519614",
"name": "translational",
"pos": [
305,
318
]
} | {
"id": "C0597295",
"name": "synthesis",
"pos": [
355,
364
]
} |
subjects discussed are colostral immunity , the ability of the piglet to mount an immune response , the effect of weaning on the immune system , factors involved in the cause of post-weaning scours and its control . | process_includes_biological_process | {
"id": "C0020964",
"name": "immunity",
"pos": [
33,
41
]
} | {
"id": "C0301872",
"name": "immune",
"pos": [
129,
135
]
} |
theories concerning histogenesis remain controversial and include two separate colliding tumors , differentiation from a single cell line , or divergent differentiation of a single cell line . | process_includes_biological_process | {
"id": "C0178679",
"name": "histogenesis",
"pos": [
20,
32
]
} | {
"id": "C0007589",
"name": "differentiation",
"pos": [
153,
168
]
} |
escherichia coli protein synthesis initiation factor if3 controls its own gene expression at the translational level in vivo . | process_includes_biological_process | {
"id": "C0017262",
"name": "gene",
"pos": [
74,
78
]
} | {
"id": "C1519614",
"name": "translational",
"pos": [
97,
110
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} |
these results indicate that the cellular levels of if3 negatively regulate the expression of its own gene , infc , at the translational level in vivo . | process_includes_biological_process | {
"id": "C0017262",
"name": "expression",
"pos": [
79,
89
]
} | {
"id": "C1519614",
"name": "translational",
"pos": [
122,
135
]
} |
most adolescent and adult patients are able to carry out their treatment independently using gravity assisted positions , breathing exercises emphasising inspiration , and the forced expiration technique . | process_includes_biological_process | {
"id": "C0035203",
"name": "breathing",
"pos": [
122,
131
]
} | {
"id": "C0004048",
"name": "inspiration",
"pos": [
154,
165
]
} |
although the degree of hazard and risk potential can be calculated in each instance , chemicals differ markedly in their ability to interfere with reproduction ( amann , 1982 ) and/or development ( johnson , 1984 ) . | process_includes_biological_process | {
"id": "C0035150",
"name": "reproduction",
"pos": [
147,
159
]
} | {
"id": "C0678723",
"name": "development",
"pos": [
184,
195
]
} |
standardized methods for reproductive and developmental toxicity safety evaluation are available for detecting adverse effects upon any aspect of reproduction and development . | process_includes_biological_process | {
"id": "C0035150",
"name": "reproduction",
"pos": [
146,
158
]
} | {
"id": "C0678723",
"name": "development",
"pos": [
163,
174
]
} |
in addition to a direct anti-viral effect , interferons have important immunological properties including effects on cell-mediated immunity and antibody production as well as cell-mediated cytolysis . | process_includes_biological_process | {
"id": "C0020966",
"name": "cell-mediated immunity",
"pos": [
117,
139
]
} | {
"id": "C0301896",
"name": "cell-mediated cytolysis",
"pos": [
175,
198
]
} |
to combat effectively the potentially debilitating disease caused by infection with these organisms we must ( a ) define the parasite products chemically , ( b ) determine their ability to induce protective immunity ( or to counter a protective immune response ) , and ( c ) establish their potential for the diagnosis of infection . | process_includes_biological_process | {
"id": "C0020964",
"name": "immunity",
"pos": [
207,
215
]
} | {
"id": "C0301872",
"name": "immune response",
"pos": [
245,
260
]
} |
the results of in vitro transcription on this plasmid template and s1 mapping assay reveal that the termination of p ' r-promoted transcription at inverted nutl site is a rho-independent event . | process_includes_biological_process | {
"id": "C0040649",
"name": "transcription",
"pos": [
24,
37
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} | {
"id": "C0597600",
"name": "termination",
"pos": [
100,
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]
} |
four major factors in the tutor 's behaviour were identified as having importance in the rating process : the ability to care for students , a knowledge of course structure and teaching staff philosophy , the ability to encourage independent thinking in students and a knowledge of the specific medical problems being studied . | process_includes_biological_process | {
"id": "C0004927",
"name": "behaviour",
"pos": [
35,
44
]
} | {
"id": "C0039869",
"name": "thinking",
"pos": [
242,
250
]
} |
these animals were observed during an additional reproduction cycle to demonstrate the possible negative effect of the hormones on the following oestrus/pregnancy . | process_includes_biological_process | {
"id": "C0035150",
"name": "reproduction",
"pos": [
49,
61
]
} | {
"id": "C0032961",
"name": "pregnancy",
"pos": [
153,
162
]
} |
gene expression : chemical synthesis of e. coli ribosome binding sites and their use in directing the expression of mammalian proteins in bacteria . | process_includes_biological_process | {
"id": "C0017262",
"name": "gene expression",
"pos": [
0,
15
]
} | {
"id": "C1171362",
"name": "expression",
"pos": [
102,
112
]
} |
aerosols of normal saline produced no change of ventilation ( vi ) , breathing frequency ( f ) , tidal volume ( vt ) , duration of inspiration ( ti ) , mean inspiratory flow ( vt/ti ) or the fraction of the breathing cycle devoted to inspiration ( ti/tt ) . | process_includes_biological_process | {
"id": "C0035203",
"name": "breathing",
"pos": [
69,
78
]
} | {
"id": "C0004048",
"name": "inspiration",
"pos": [
234,
245
]
} |
the described changes in energy metabolism parameters are determined by impairment of the interplay between glycolysis and oxidative phosphorylation . | process_includes_biological_process | {
"id": "C0014272",
"name": "energy metabolism",
"pos": [
25,
42
]
} | {
"id": "C0017952",
"name": "glycolysis",
"pos": [
108,
118
]
} |
in subjects breathing rapidly at 30 breaths/min with inspired volumes in excess of 2 liters , vrd had values three or more times greater than the predicted anatomical dead space ( vd ) . | process_includes_biological_process | {
"id": "C0035203",
"name": "breathing",
"pos": [
12,
21
]
} | {
"id": "C0004048",
"name": "inspired",
"pos": [
53,
61
]
} |
the histogenesis and varied cellular pattern of the peripheral ameloblastoma and several other related odontogenic lesions of the gingiva illustrate the proliferative and differentiation potential of the basal cell layer of gingival epithelium . | process_includes_biological_process | {
"id": "C0178679",
"name": "histogenesis",
"pos": [
4,
16
]
} | {
"id": "C0007589",
"name": "differentiation",
"pos": [
171,
186
]
} |
at earlier stages of circulatory insufficiency , left ventricular blood filling post-infarction patients becomes discordinated , as reflected in enhanced blood filling during the slow-filling and atrial systolic phases and reduced blood filling during the fast-filling phase , which is supposed to be of compensatory nature and contribute to the frank -- starling effect . | process_includes_biological_process | {
"id": "C0005775",
"name": "circulatory",
"pos": [
21,
32
]
} | {
"id": "C0039155",
"name": "systolic",
"pos": [
203,
211
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} |
two interpretations of these results are considered : ( 1 ) that tooth pulp afferents may have some unspecified sensory function besides mediation of painful sensations and ( 2 ) that they may be specialized in the mediation of nociceptive impulses but may give rise to innocuous sensations under special circumstances . | process_includes_biological_process | {
"id": "C0234194",
"name": "of painful",
"pos": [
147,
157
]
} | {
"id": "C1518343",
"name": "nociceptive",
"pos": [
228,
239
]
} |
this specific transcription is discussed in relation to initiation of primer rna synthesis for heavy-strand replication of rat mtdna . | process_includes_biological_process | {
"id": "C0040649",
"name": "transcription",
"pos": [
14,
27
]
} | {
"id": "C1328948",
"name": "rna synthesis",
"pos": [
77,
90
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} |
flow cytometric techniques are presented which allow to determine parameters of cell proliferation kinetics by means of histogram sequences after special manipulations of the cell culture under investigation : ( a ) in the stathmokinetic method metaphase blocking agents are applied which allow the cells of the population to continue progression through interphase and accumulate at 4c dna content . | process_includes_biological_process | {
"id": "C0596290",
"name": "cell proliferation",
"pos": [
80,
98
]
} | {
"id": "C0025564",
"name": "metaphase",
"pos": [
245,
254
]
} |
flow cytometric techniques are presented which allow to determine parameters of cell proliferation kinetics by means of histogram sequences after special manipulations of the cell culture under investigation : ( a ) in the stathmokinetic method metaphase blocking agents are applied which allow the cells of the population to continue progression through interphase and accumulate at 4c dna content . | process_includes_biological_process | {
"id": "C0596290",
"name": "cell proliferation",
"pos": [
80,
98
]
} | {
"id": "C0021798",
"name": "interphase",
"pos": [
355,
365
]
} |
the immune responses that were monitored for six weeks were total lymphocyte and lymphocyte subpopulation counts , pha stimulated lymphocyte transformation , leucocyte migration inhibition , measles antibody titres and serum levels of immunoglobulins and complement components . | process_includes_biological_process | {
"id": "C0301872",
"name": "immune responses",
"pos": [
4,
20
]
} | {
"id": "C0024262",
"name": "lymphocyte transformation",
"pos": [
130,
155
]
} |
during the development of the embryoid tissue there is an increase in cell division and the differentiation of vascular cells with secondary thickened walls . | process_includes_biological_process | {
"id": "C0178679",
"name": "development",
"pos": [
11,
22
]
} | {
"id": "C0007589",
"name": "the differentiation",
"pos": [
88,
107
]
} |
in no other period of life than old age do neurophysiologic alterations seem to affect behavior and cognition so significantly . | process_includes_biological_process | {
"id": "C0004927",
"name": "behavior",
"pos": [
87,
95
]
} | {
"id": "C0009240",
"name": "cognition",
"pos": [
100,
109
]
} |
the observed suppression of tumour-associated immunity in the presence of husepl provides further evidence for the suppressive activity of sepl on a range of in vitro immune response in normal murine and human hosts . | process_includes_biological_process | {
"id": "C0020964",
"name": "immunity",
"pos": [
46,
54
]
} | {
"id": "C0301872",
"name": "immune response",
"pos": [
167,
182
]
} |
oligonucleotide sequence analyses indicate that vesicular stomatitis virus large defective interfering virus particle rna is made by internal deletion : evidence for similar transcription polyadenylation signals for the synthesis of all vesicular stomatitis virus mrna species . | process_includes_biological_process | {
"id": "C0040649",
"name": "transcription",
"pos": [
174,
187
]
} | {
"id": "C0949765",
"name": "polyadenylation",
"pos": [
188,
203
]
} |
to establish the mode of gene expression specified by transposon , we investigated the correlation among the homology of the dna sequence , the extent of transposon-specific transcription , the specific activity of penicillinase ( pcase ) per cell , and the transposition frequency by using two ampicillin resistance transposons ( tnas ) , tn2601 and tn2602 . | process_includes_biological_process | {
"id": "C0017262",
"name": "gene expression",
"pos": [
25,
40
]
} | {
"id": "C0040649",
"name": "transcription",
"pos": [
174,
187
]
} |
the results are discussed from the standpoint of the evolutionary formation of the thalamo-frontal association system of the brain , connected with the formation of behavior programs in accordance with current biological motivation . | process_includes_biological_process | {
"id": "C0004927",
"name": "behavior",
"pos": [
165,
173
]
} | {
"id": "C0026605",
"name": "motivation",
"pos": [
221,
231
]
} |
the survival of cells and yield of dna single-strand breaks after the completion of dna repair in growth medium m9 and in the buffer at 30 degrees and 43 degrees c has been investigated in four strains of alpha-irradiated escherichia coli : pc3 dnagts , ny73 dnagts pola1 , w3110 pol+ , p3478 pola1 . | process_includes_biological_process | {
"id": "C0007620",
"name": "survival",
"pos": [
4,
12
]
} | {
"id": "C0012899",
"name": "dna repair",
"pos": [
84,
94
]
} |
hypercapnia , hypoxemia , and chemoreceptor stimulation each stimulated respiration and simultaneously decreased r1x during both inspiration and expiration . | process_includes_biological_process | {
"id": "C0035203",
"name": "respiration",
"pos": [
72,
83
]
} | {
"id": "C0004048",
"name": "inspiration",
"pos": [
129,
140
]
} |
hypercapnia , hypoxemia , and chemoreceptor stimulation each stimulated respiration and simultaneously decreased r1x during both inspiration and expiration . | process_includes_biological_process | {
"id": "C0035203",
"name": "respiration",
"pos": [
72,
83
]
} | {
"id": "C0231800",
"name": "expiration",
"pos": [
145,
155
]
} |
according to most behavioural , electrophysiological , and clinical studies , the cingulate gyrus is widely thought to be involved in regulation of emotional life , reactivity to painful stimuli , memory processing , and attention to sensory stimuli . | process_includes_biological_process | {
"id": "C0004927",
"name": "behavioural",
"pos": [
18,
29
]
} | {
"id": "C0039869",
"name": "thought",
"pos": [
108,
115
]
} |
our experiments demonstrate that morphine and haloperidol produce two distinct and contrasting behavioral states , which can be thought of as exaggerated , isolated , and simplified forms of organized adaptive behavioral states functioning as components of normal motivated behavior . | process_includes_biological_process | {
"id": "C0004927",
"name": "behavioral",
"pos": [
95,
105
]
} | {
"id": "C0039869",
"name": "thought",
"pos": [
128,
135
]
} |
seven blood groups , one serum protein , and four milk proteins were analyzed for relation to reproductive traits including conception rate and days open . | process_includes_biological_process | {
"id": "C0035150",
"name": "reproductive",
"pos": [
94,
106
]
} | {
"id": "C0009637",
"name": "conception",
"pos": [
124,
134
]
} |
there must be evidence of gradual progressive mental deterioration in attention , learning , memory , cognitive style , motivation , and higher order thinking . | process_includes_biological_process | {
"id": "C0023185",
"name": "learning",
"pos": [
82,
90
]
} | {
"id": "C0026605",
"name": "motivation",
"pos": [
120,
130
]
} |
this study details the reproductive experience of 80 pregnant patients with significant hemoglobinopathies , 75 of whom were treated with partial prophylactic exchange transfusions during gestation . | process_includes_biological_process | {
"id": "C0035150",
"name": "reproductive",
"pos": [
23,
35
]
} | {
"id": "C0032961",
"name": "gestation",
"pos": [
188,
197
]
} |
subjects were told either ( a ) that they would inhale a substance which would make their breathing better , ( b ) that they would inhale a substance which would make their breathing worse , or ( c ) that they would inhale a substance which would have no effect on their breathing . | process_includes_biological_process | {
"id": "C0035203",
"name": "breathing",
"pos": [
90,
99
]
} | {
"id": "C0004048",
"name": "inhale",
"pos": [
216,
222
]
} |
these results underline the key role of thyroid hormones in regulating development and maturation of skeletal muscle throughout the preweaning and postweaning phases of growth . | process_includes_biological_process | {
"id": "C0678723",
"name": "development",
"pos": [
71,
82
]
} | {
"id": "C1160401",
"name": "maturation",
"pos": [
87,
97
]
} |
protein a defined as one of the components of the wall of staphylococcus aureus cowans 1 has shown its effects as modifier of the immune response : it induce changes in cellular receptors , polyclonal activation of t and b lymphocytes , liberation of lymphokines , increase in the production of gamma-interferon ( probably as the result of activation of nk cells ) . | process_includes_biological_process | {
"id": "C0301872",
"name": "immune response",
"pos": [
130,
145
]
} | {
"id": "C1155064",
"name": "activation",
"pos": [
340,
350
]
} |
on the other hand , the pregnant f2 females were judged to have normal reproductive ability , based on observations of the numbers of corpora lutea , implantations and live fetuses at day 14 of pregnancy . | process_includes_biological_process | {
"id": "C0035150",
"name": "reproductive",
"pos": [
71,
83
]
} | {
"id": "C0032961",
"name": "pregnancy",
"pos": [
194,
203
]
} |
genetic studies have shown that expression of the e. coli threonyl-trna synthetase ( thrs ) gene is negatively auto-regulated at the translational level . | process_includes_biological_process | {
"id": "C0017262",
"name": "expression",
"pos": [
32,
42
]
} | {
"id": "C1519614",
"name": "translational",
"pos": [
133,
146
]
} |
the primary mode of control of atp gene expression is exercised at the translational level . | process_includes_biological_process | {
"id": "C0017262",
"name": "gene expression",
"pos": [
35,
50
]
} | {
"id": "C1519614",
"name": "translational",
"pos": [
71,
84
]
} |
in addition we have presented models for transcription termination within and at the end of a gene , which are consistent with the available information on the transcription bubble propagated during transcription elongation and can explain the modes of transcription termination described for various eukaryotic genes . | process_includes_biological_process | {
"id": "C0040649",
"name": "transcription",
"pos": [
41,
54
]
} | {
"id": "C1519591",
"name": "transcription elongation",
"pos": [
199,
223
]
} |
in addition we have presented models for transcription termination within and at the end of a gene , which are consistent with the available information on the transcription bubble propagated during transcription elongation and can explain the modes of transcription termination described for various eukaryotic genes . | process_includes_biological_process | {
"id": "C0040649",
"name": "transcription",
"pos": [
41,
54
]
} | {
"id": "C0597600",
"name": "transcription termination",
"pos": [
253,
278
]
} |
the expression of the c. jejuni glya gene was probably via transcription initiated from its own promoter . | process_includes_biological_process | {
"id": "C0017262",
"name": "expression",
"pos": [
4,
14
]
} | {
"id": "C0040649",
"name": "transcription",
"pos": [
59,
72
]
} |
expression of foreign genes in escherichia coli requires the juxtaposition of prokaryotic transcription and translation elements with a coding region for the foreign gene . | process_includes_biological_process | {
"id": "C0017262",
"name": "expression",
"pos": [
0,
10
]
} | {
"id": "C0040649",
"name": "transcription",
"pos": [
90,
103
]
} |
the start point of transcription was mapped 50 nucleotides upstream from the putative start codon , and a sequence caatg was found 5 ' to the polyadenylation site of the transcript that could play a role in selection of the polyadenylation site . | process_includes_biological_process | {
"id": "C0040649",
"name": "transcription",
"pos": [
19,
32
]
} | {
"id": "C0949765",
"name": "polyadenylation",
"pos": [
224,
239
]
} |
primer extension analysis showed one transcription start point , and s1 mapping analysis showed two blocks of polyadenylation sites in normal pituitaries . | process_includes_biological_process | {
"id": "C0040649",
"name": "transcription",
"pos": [
37,
50
]
} | {
"id": "C0949765",
"name": "polyadenylation",
"pos": [
110,
125
]
} |
first , the incongruent behavior attributed to dispositional causes was more likely to be recalled than that attributed to situational ones , only when the target schema became well-organized by thinking about the target . | process_includes_biological_process | {
"id": "C0004927",
"name": "behavior",
"pos": [
24,
32
]
} | {
"id": "C0039869",
"name": "thinking",
"pos": [
195,
203
]
} |
we recorded wheezes , pleural pressure , plethysmographic lung volumes and mouth flow rates in 6 healthy subjects during maximal expiratory maneuvers breathing air and a mixture of 80 % he-20 % o2 ( he ) before and after methacholine inhalation . | process_includes_biological_process | {
"id": "C0035203",
"name": "breathing",
"pos": [
150,
159
]
} | {
"id": "C0004048",
"name": "inhalation",
"pos": [
234,
244
]
} |
the microbes also possess the capability of escaping host defenses by enhancing their ability to adhere to mucosal surfaces , impairing mucociliary function and evading phagocytosis . | process_includes_biological_process | {
"id": "C0520990",
"name": "host defenses",
"pos": [
53,
66
]
} | {
"id": "C0031308",
"name": "phagocytosis",
"pos": [
169,
181
]
} |
it is clear that even if these lectins are involved in only a few of these fundamental processes , it is important to elucidate their functions and the mechanisms by which their expression is regulated during neoplastic transformation and tumor progression and the suppression of the transformed phenotype . | process_includes_biological_process | {
"id": "C0007621",
"name": "neoplastic transformation",
"pos": [
209,
234
]
} | {
"id": "C1510411",
"name": "transformed",
"pos": [
284,
295
]
} |
the supply of substrates for tumour energy metabolism can be reduced by dietary manipulation ( e.g . ketogenic diet ) or by pharmacological means at the cellular level ( e.g . inhibitors of glycolysis or oxidative phosphorylation ) . | process_includes_biological_process | {
"id": "C0014272",
"name": "energy metabolism",
"pos": [
36,
53
]
} | {
"id": "C0017952",
"name": "glycolysis",
"pos": [
190,
200
]
} |
such artificial endonucleases could be used , among other things , to map genes on long dna fragments , to induce site-specific mutations or to block gene expression at the transcriptional level . | process_includes_biological_process | {
"id": "C0017262",
"name": "gene expression",
"pos": [
150,
165
]
} | {
"id": "C0040649",
"name": "transcriptional",
"pos": [
173,
188
]
} |
a stable arterial hypertension was obtained in dogs by means of experimental pathology of higher nervous activity ( behavior ) produced with a prolonged work of the brain in conditions of unfavourably combined triad of factors : large volume of information to be processed and assimilated , the factor of time set for such brain work , and a high level of behavioral motivation . | process_includes_biological_process | {
"id": "C0004927",
"name": "behavioral",
"pos": [
356,
366
]
} | {
"id": "C0026605",
"name": "motivation",
"pos": [
367,
377
]
} |
12-week old spontaneously hypertensive ( shr ) rats in comparison with normotensive wistar-kyoto ( wky ) rats had an enhanced behavioural activity associated with exploratory motivation and a lower one associated with the fear motivation , their daily activity and the activity associated with alternating illumination were also higher whereas their defecation was lower . | process_includes_biological_process | {
"id": "C0004927",
"name": "behavioural",
"pos": [
126,
137
]
} | {
"id": "C0026605",
"name": "motivation",
"pos": [
227,
237
]
} |
sequence and expression of the cc gene , a member of the dopa decarboxylase gene cluster of drosophila : possible translational regulation . | process_includes_biological_process | {
"id": "C0017262",
"name": "expression",
"pos": [
13,
23
]
} | {
"id": "C3537096",
"name": "translational regulation",
"pos": [
114,
138
]
} |
thus , although nitrogen control of nif gene expression requires the products of regulatory genes for which constitutive mutations can be isolated , oxygen appears instead to prevent the adoption of a dna conformation necessary , directly or indirectly , for nif gene transcription . | process_includes_biological_process | {
"id": "C0017262",
"name": "gene",
"pos": [
40,
44
]
} | {
"id": "C0040649",
"name": "gene transcription",
"pos": [
263,
281
]
} |
in most cases , the respiration course during the dyspnea stage by occlusion of the trachea generally had an inspiratory character . | process_includes_biological_process | {
"id": "C0035203",
"name": "respiration",
"pos": [
20,
31
]
} | {
"id": "C0004048",
"name": "inspiratory",
"pos": [
109,
120
]
} |
[ effect of the heterogeneity of persons vaccinated , with respect to the state of their immune system , on the intensity of the immune response ] . | process_includes_biological_process | {
"id": "C0020964",
"name": "state",
"pos": [
74,
79
]
} | {
"id": "C0301872",
"name": "immune response",
"pos": [
129,
144
]
} |
women of reproductive age with chronic medical disorders are often concerned about hazards from drug exposure during pregnancy . | process_includes_biological_process | {
"id": "C0035150",
"name": "reproductive",
"pos": [
9,
21
]
} | {
"id": "C0032961",
"name": "pregnancy",
"pos": [
117,
126
]
} |
we conducted a study to determine if bretylium tosylate ( bt ) is effective in the prophylaxis and treatment of hypothermic ventricular fibrillation ( vf ) in the setting of various maneuvers thought to induce this lethal arrhythmia . | process_includes_biological_process | {
"id": "C0004927",
"name": "conducted",
"pos": [
3,
12
]
} | {
"id": "C0039869",
"name": "thought",
"pos": [
192,
199
]
} |
this good reproductive performance was attributed to the fact that weight-for-height remained acceptable during pregnancy , in spite of low weight gain because of an acceptable pre-pregnant weight . | process_includes_biological_process | {
"id": "C0035150",
"name": "reproductive",
"pos": [
10,
22
]
} | {
"id": "C0032961",
"name": "pregnancy",
"pos": [
112,
121
]
} |
furthermore , the results indicate that the specificity of the immune response of mice to tumors as defined by transplantation immunity in vivo and lymphocyte cytotoxicity in vitro may be quite different . | process_includes_biological_process | {
"id": "C0020964",
"name": "immunity",
"pos": [
127,
135
]
} | {
"id": "C0301896",
"name": "lymphocyte cytotoxicity",
"pos": [
148,
171
]
} |
changes in c-fos and c-myc oncogene expression may be casually linked to late stages of neoplastic transformation in these chemically and radiation transformed 10t1/2 cell lines . | process_includes_biological_process | {
"id": "C0007621",
"name": "neoplastic transformation",
"pos": [
88,
113
]
} | {
"id": "C1510411",
"name": "transformed",
"pos": [
148,
159
]
} |
mice may be particularly sensitive to urethan during cell division , making strains with a higher rate of mitosis more susceptible to tumorigenesis . | process_includes_biological_process | {
"id": "C0007590",
"name": "cell division",
"pos": [
53,
66
]
} | {
"id": "C0026255",
"name": "mitosis",
"pos": [
106,
113
]
} |
energy production via oxidative metabolism is impaired but glycolysis may be increased in the calf muscle of patients with intermittent claudication . | process_includes_biological_process | {
"id": "C0014272",
"name": "energy",
"pos": [
0,
6
]
} | {
"id": "C0017952",
"name": "glycolysis",
"pos": [
59,
69
]
} |
no adverse effects on fertility , general reproductive parameters , or offspring survival and development were evident at doses employed in these studies . | process_includes_biological_process | {
"id": "C0035150",
"name": "reproductive",
"pos": [
42,
54
]
} | {
"id": "C0678723",
"name": "development",
"pos": [
94,
105
]
} |
preweaning and postweaning growth rates and reproductive performance as assessed by litter size , conception rate and litter interval , were comparable for the four treatments . | process_includes_biological_process | {
"id": "C0035150",
"name": "reproductive",
"pos": [
44,
56
]
} | {
"id": "C0009637",
"name": "conception",
"pos": [
98,
108
]
} |
the following survey conducted at spectrum house of westboro and worcester , massachusetts , seeks to identify the needs and thoughts of this group of individuals who are at a high risk for contracting aids , in hopes of providing a solution to this national crisis -- something in addition to prayer . | process_includes_biological_process | {
"id": "C0004927",
"name": "conducted",
"pos": [
21,
30
]
} | {
"id": "C0039869",
"name": "thoughts",
"pos": [
125,
133
]
} |
this increased transcription appeared to be independent of the sucrose-regulated transcription termination , suggesting the existence of at least two different mechanisms for the regulation of sacb expression . | process_includes_biological_process | {
"id": "C0040649",
"name": "transcription",
"pos": [
15,
28
]
} | {
"id": "C0597600",
"name": "transcription termination",
"pos": [
81,
106
]
} |
a transcriptional run-off assay was performed when intact isolated nuclei were allowed to continue rna synthesis in an in vitro reaction . | process_includes_biological_process | {
"id": "C0040649",
"name": "transcriptional",
"pos": [
2,
17
]
} | {
"id": "C1328948",
"name": "rna synthesis",
"pos": [
99,
112
]
} |
the decrease in the transcription and polyadenylation of nuclear rna may contribute to the decline in neuronal protein synthesis observed in old animals . | process_includes_biological_process | {
"id": "C0040649",
"name": "transcription",
"pos": [
20,
33
]
} | {
"id": "C0949765",
"name": "polyadenylation",
"pos": [
38,
53
]
} |
there were no effects of morphine on the behavioral detection latencies to the innocuous cooling and visual stimuli , indicating that the effects of morphine were modality-specific and independent of changes in motivation , attention , or motoric ability . | process_includes_biological_process | {
"id": "C0004927",
"name": "behavioral",
"pos": [
41,
51
]
} | {
"id": "C0026605",
"name": "motivation",
"pos": [
211,
221
]
} |
because of the differences in the histogenesis and prognosis , such cases should be differentiated from cases of carcinosarcoma of the urinary bladder . | process_includes_biological_process | {
"id": "C0178679",
"name": "histogenesis",
"pos": [
34,
46
]
} | {
"id": "C0007589",
"name": "differentiated",
"pos": [
84,
98
]
} |
aside from enabling the analysis of responses , tests that induce reflexive as well as nonreflexive behavior may have the capacity to separate the more complex aspects of pain such as the possible presence of two components of pain , sensory/discriminative and motivational/affective . | process_includes_biological_process | {
"id": "C0004927",
"name": "behavior",
"pos": [
100,
108
]
} | {
"id": "C0026605",
"name": "motivational",
"pos": [
261,
273
]
} |
algodystrophic patients actually had local circulatory abnormalities consisting of an increase in mean velocity with a diastolic component . | process_includes_biological_process | {
"id": "C0005775",
"name": "circulatory",
"pos": [
43,
54
]
} | {
"id": "C0012000",
"name": "diastolic",
"pos": [
119,
128
]
} |
the response consists of an immediate and generalized arrest of spontaneous movements , including respiration and expiration , reduced muscular tone , and unresponsiveness to pinching . | process_includes_biological_process | {
"id": "C0035203",
"name": "respiration",
"pos": [
98,
109
]
} | {
"id": "C0231800",
"name": "expiration",
"pos": [
114,
124
]
} |
we approached the problem of expression of the five genes in escherichia coli and , although we obtained high levels of transcription of the native pertussis toxin genes , the amount of proteins produced was very low or undetectable . | process_includes_biological_process | {
"id": "C0017262",
"name": "expression",
"pos": [
29,
39
]
} | {
"id": "C0040649",
"name": "transcription",
"pos": [
120,
133
]
} |
loaded breathing produced inspiratory muscle fatigue and a progressive increase in the sense of effort over time in all subjects . | process_includes_biological_process | {
"id": "C0035203",
"name": "breathing",
"pos": [
7,
16
]
} | {
"id": "C0004048",
"name": "inspiratory",
"pos": [
26,
37
]
} |
while breathing 100 % o2 , five dogs showed prolonged electrical activity of the diaphragm and parasternal intercostals in early expiration , postinspiratory inspiratory activity ( piia ) . | process_includes_biological_process | {
"id": "C0035203",
"name": "breathing",
"pos": [
6,
15
]
} | {
"id": "C0004048",
"name": "inspiratory",
"pos": [
158,
169
]
} |
the three identified factors were termed negative self-esteem , anergy , and dysphoria and were considered to correspond with the cognitive , behavioral , and affective components that generally are thought to be part of the depressive syndrome . | process_includes_biological_process | {
"id": "C0004927",
"name": "behavioral",
"pos": [
142,
152
]
} | {
"id": "C0039869",
"name": "thought",
"pos": [
199,
206
]
} |
these results provide the first evidence that ifn can modulate ribosomal gene expression at the post-transcriptional level . | process_includes_biological_process | {
"id": "C0017262",
"name": "gene expression",
"pos": [
73,
88
]
} | {
"id": "C0040649",
"name": "transcriptional",
"pos": [
101,
116
]
} |
transmembrane signaling through b cell mhc class ii molecules : anti-ia antibodies induce protein kinase c translocation to the nuclear fraction . | process_includes_biological_process | {
"id": "C0037083",
"name": "signaling",
"pos": [
14,
23
]
} | {
"id": "C1518440",
"name": "translocation",
"pos": [
107,
120
]
} |
these results indicate that expression of the pg19 proteoglycan gene is regulated both in terms of cell-type-specific transcription and selection of a transcriptional start site . | process_includes_biological_process | {
"id": "C0017262",
"name": "expression",
"pos": [
28,
38
]
} | {
"id": "C0040649",
"name": "transcription",
"pos": [
151,
164
]
} |
by contrast , while serum-stimulated quiescent g0 cells at 41 degrees c replicate dna and divide , serum did not induce g2-arrested cells to enter mitosis , indicating that serum growth factors may trigger events in the g1 phase that ultimately determine g2 transit . | process_includes_biological_process | {
"id": "C0007590",
"name": "cells",
"pos": [
50,
55
]
} | {
"id": "C0026255",
"name": "mitosis",
"pos": [
147,
154
]
} |
expression of mouse histone genes : transcription into 3 ' intergenic dna and cryptic processing sites downstream from the 3 ' end of the h3 gene . | process_includes_biological_process | {
"id": "C0017262",
"name": "expression",
"pos": [
0,
10
]
} | {
"id": "C0040649",
"name": "transcription",
"pos": [
36,
49
]
} |
we examined the regulation of ribosomal protein ( r-protein ) gene expression and found that , at the start of development , expression of these genes was drastically and specifically reduced by a block to translational initiation . | process_includes_biological_process | {
"id": "C0017262",
"name": "expression",
"pos": [
67,
77
]
} | {
"id": "C1519613",
"name": "translational initiation",
"pos": [
206,
230
]
} |
a 1985 study was conducted concerning physician motivation to form an association with nurse practitioners . | process_includes_biological_process | {
"id": "C0004927",
"name": "conducted",
"pos": [
17,
26
]
} | {
"id": "C0026605",
"name": "motivation",
"pos": [
48,
58
]
} |
transcription assays with these sp6 promoter mutants revealed that not only the sequence immediately upstream of the initiation site but also the six base pairs from position +1 to +6 are important elements for promoter binding and/or transcription initiation activity . | process_includes_biological_process | {
"id": "C0040649",
"name": "transcription",
"pos": [
0,
13
]
} | {
"id": "C1158830",
"name": "transcription initiation",
"pos": [
235,
259
]
} |
sequence similarities between regions at the 5 ' and 3 ' termini of this human gene and a chicken h3.3 gene lead us to propose that either the previous assignments of termini of the chicken gene are in error , or there are alternative transcription start and polyadenylation sites . | process_includes_biological_process | {
"id": "C0040649",
"name": "transcription",
"pos": [
235,
248
]
} | {
"id": "C0949765",
"name": "polyadenylation",
"pos": [
259,
274
]
} |
to test whether the mutation responsible for the loss of alpha-globin gene expression ( hemoglobin h disease ) in these patients is linked with the alpha-globin genes on chromosome 16 , we transferred chromosome 16 from preleukemic patients with acquired hemoglobin h disease to mouse erythroleukemia cells and measured the transcriptional activity of the human alpha-globin genes . | process_includes_biological_process | {
"id": "C0017262",
"name": "gene expression",
"pos": [
70,
85
]
} | {
"id": "C0040649",
"name": "transcriptional",
"pos": [
324,
339
]
} |
a variety of sex allocation models is considered in which the reproductive returns on investment in males differ from the returns on investment in females , the amounts of resources available for reproduction vary in the population , the costs of making male and female reproductive structures differ , and the conception sex ratio may be fixed and there may be an initial minimum investment per offspring . | process_includes_biological_process | {
"id": "C0035150",
"name": "reproductive",
"pos": [
62,
74
]
} | {
"id": "C0009637",
"name": "conception",
"pos": [
311,
321
]
} |
another possible function is a role for angiotensin in the activity of gonadotropic hormone releasing hormones and pituitary hormones during the reproductive cycle and pregnancy . | process_includes_biological_process | {
"id": "C0035150",
"name": "reproductive",
"pos": [
145,
157
]
} | {
"id": "C0032961",
"name": "pregnancy",
"pos": [
168,
177
]
} |
two ways of yolk sac tumor histogenesis are discussed : differentiation of embryonal carcinoma cells , and redifferentiation of the polypotent undifferentiated anaplastic seminoma cells . | process_includes_biological_process | {
"id": "C0178679",
"name": "histogenesis",
"pos": [
27,
39
]
} | {
"id": "C0007589",
"name": "differentiation",
"pos": [
109,
124
]
} |
cohort studies of adverse reproductive effects of occupational exposures that compare the outcome of exposed pregnancies with non-exposed pregnancies among the same group of mothers ( internal controls ) and among a different group of mothers ( external controls ) have been reviewed . | process_includes_biological_process | {
"id": "C0035150",
"name": "reproductive",
"pos": [
26,
38
]
} | {
"id": "C0032961",
"name": "pregnancies",
"pos": [
138,
149
]
} |
three types of muscle-specific gene expression in fusion-blocked rat skeletal muscle cells : translational control in egta-treated cells . | process_includes_biological_process | {
"id": "C0017262",
"name": "gene expression",
"pos": [
31,
46
]
} | {
"id": "C1519614",
"name": "translational",
"pos": [
93,
106
]
} |
the genetic events that lead to cellular oncogene activation may result in the excessive or inappropriate expression of the gene , or the expression of an aberrant gene product . | process_includes_biological_process | {
"id": "C0017262",
"name": "expression",
"pos": [
106,
116
]
} | {
"id": "C1171362",
"name": "expression",
"pos": [
138,
148
]
} |
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