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it is supposed that along with the beta-adrenoreceptor block the antiarrhythmic effect of alpheprol was also caused by quinidine-like action of the preparation . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
65,
79
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
119,
128
]
} |
the influence of the host immunosuppression on antimycobacterial effects of isoniazid , rifampicin or streptomycin was studied on animal models . | therapeutic_class_of | {
"id": "C0360390",
"name": "antimycobacterial",
"pos": [
47,
64
]
} | {
"id": "C0038425",
"name": "streptomycin",
"pos": [
102,
114
]
} |
a contribution to studies on the influence of edta and ca2+ on the antibacterial activity of neomycin on pseudomonas aeruginosa . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
67,
80
]
} | {
"id": "C0027603",
"name": "neomycin",
"pos": [
93,
101
]
} |
in vitro studies on increased antibacterial activity of neomycin in the presence of certain steroids . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
30,
43
]
} | {
"id": "C0027603",
"name": "neomycin",
"pos": [
56,
64
]
} |
[ experimental test using a new antidepressive ( thiazenone , sq 10496 ) . a controlled study using imipramine and placebo ] . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressive",
"pos": [
32,
46
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
100,
110
]
} |
these findings may help to explain why antidepressant effects are observed clinically only after long-termn treatment with imipramine . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
39,
53
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
123,
133
]
} |
a side effect of long-term administration of the anti-epileptic drug phenytoin is overgrowth of the connective tissues surrounding the teeth . | therapeutic_class_of | {
"id": "C0003299",
"name": "anti-epileptic",
"pos": [
49,
63
]
} | {
"id": "C0031507",
"name": "phenytoin",
"pos": [
69,
78
]
} |
we have previously reported the antimalarial activity of imidazoles and amphotericin b against chloroquine-resistant plasmodium falciparum . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial",
"pos": [
32,
44
]
} | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
95,
106
]
} |
in the present study the role of amygdala in the antidepressant action of imipramine is discussed . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
49,
63
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
74,
84
]
} |
moreover , multi-drug antiepileptics including phenytoin have been reported to induce carcinogenic damage and coagulation defects . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptics",
"pos": [
22,
36
]
} | {
"id": "C0031507",
"name": "phenytoin",
"pos": [
47,
56
]
} |
administration of the anti-epileptic drug valproic acid at various selected doses resulted in persistent drug concentrations spanning from subtherapeutic to toxic levels . | therapeutic_class_of | {
"id": "C0003299",
"name": "anti-epileptic",
"pos": [
22,
36
]
} | {
"id": "C0042291",
"name": "valproic acid",
"pos": [
42,
55
]
} |
since little is established on the effect of antidepressant drugs on local functional activity throughout the brain , we have employed this technique to study the effects of desmethylimipramine ( dmi ) , a tricyclic antidepressant , and assessing the effect of centrally acting drugs on local neuronal function in the brain . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
45,
59
]
} | {
"id": "C0011685",
"name": "desmethylimipramine",
"pos": [
174,
193
]
} |
since little is established on the effect of antidepressant drugs on local functional activity throughout the brain , we have employed this technique to study the effects of desmethylimipramine ( dmi ) , a tricyclic antidepressant , and assessing the effect of centrally acting drugs on local neuronal function in the brain . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
45,
59
]
} | {
"id": "C0011685",
"name": "dmi",
"pos": [
196,
199
]
} |
voltage- and time-dependent depression of maximum rate of depolarisation of guinea-pig ventricular action potentials by two new antiarrhythmic drugs , flecainide and lorcainide . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drugs",
"pos": [
128,
148
]
} | {
"id": "C0016229",
"name": "flecainide",
"pos": [
151,
161
]
} |
using desjardins ' technique for the testing of antimalarials against plasmodium falciparum in vitro , a 4-year-old solution of mefloquine in water ( 10 ( -3 ) mol/litre ) was compared with a freshly prepared solution . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarials",
"pos": [
48,
61
]
} | {
"id": "C0025153",
"name": "mefloquine",
"pos": [
128,
138
]
} |
the antibacterial activity of norfloxacin , an organic acid structurally related to nalidixic acid , was compared with that of the oral cephalosporins cefaclor and cephalexin , and with that of nalidixic acid , cinoxacin , amikacin , ampicillin , trimethoprim alone and the combination of trimethoprim and sulfamethoxazole . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0007537",
"name": "cefaclor",
"pos": [
151,
159
]
} |
the antibacterial activity of norfloxacin , an organic acid structurally related to nalidixic acid , was compared with that of the oral cephalosporins cefaclor and cephalexin , and with that of nalidixic acid , cinoxacin , amikacin , ampicillin , trimethoprim alone and the combination of trimethoprim and sulfamethoxazole . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
164,
174
]
} |
the antibacterial activity of norfloxacin , an organic acid structurally related to nalidixic acid , was compared with that of the oral cephalosporins cefaclor and cephalexin , and with that of nalidixic acid , cinoxacin , amikacin , ampicillin , trimethoprim alone and the combination of trimethoprim and sulfamethoxazole . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0002499",
"name": "amikacin",
"pos": [
223,
231
]
} |
the antibacterial activity of norfloxacin , an organic acid structurally related to nalidixic acid , was compared with that of the oral cephalosporins cefaclor and cephalexin , and with that of nalidixic acid , cinoxacin , amikacin , ampicillin , trimethoprim alone and the combination of trimethoprim and sulfamethoxazole . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
234,
244
]
} |
the antibacterial activity of norfloxacin , an organic acid structurally related to nalidixic acid , was compared with that of the oral cephalosporins cefaclor and cephalexin , and with that of nalidixic acid , cinoxacin , amikacin , ampicillin , trimethoprim alone and the combination of trimethoprim and sulfamethoxazole . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0041041",
"name": "trimethoprim",
"pos": [
289,
301
]
} |
a randomized double-blind cross-over trial was carried out in 20 patients suffering from ventricular ectopic contractions ( vecs ) , in order to evaluate the effectiveness of a new antiarrhythmic drug , propafenone ( p ) , versus lorajmine ( l ) . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drug",
"pos": [
181,
200
]
} | {
"id": "C0033429",
"name": "propafenone",
"pos": [
203,
214
]
} |
the antimicrobial combinations used were penicillin plus clavulanic acid and metronidazole plus penicillin , oxacillin , or gentamicin . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial",
"pos": [
4,
17
]
} | {
"id": "C0025872",
"name": "metronidazole",
"pos": [
77,
90
]
} |
a comparison with anticonvulsant ed50 values of common antiepileptics in the gerbil showed that these four gabamimetics were clearly more potent than phenobarbital , phenytoin , carbamazepine , ethosuximide and valproic acid and were only surpassed in potency by diazepam . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptics",
"pos": [
55,
69
]
} | {
"id": "C0031507",
"name": "phenytoin",
"pos": [
166,
175
]
} |
a comparison with anticonvulsant ed50 values of common antiepileptics in the gerbil showed that these four gabamimetics were clearly more potent than phenobarbital , phenytoin , carbamazepine , ethosuximide and valproic acid and were only surpassed in potency by diazepam . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptics",
"pos": [
55,
69
]
} | {
"id": "C0015043",
"name": "ethosuximide",
"pos": [
194,
206
]
} |
a comparison with anticonvulsant ed50 values of common antiepileptics in the gerbil showed that these four gabamimetics were clearly more potent than phenobarbital , phenytoin , carbamazepine , ethosuximide and valproic acid and were only surpassed in potency by diazepam . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptics",
"pos": [
55,
69
]
} | {
"id": "C0042291",
"name": "valproic acid",
"pos": [
211,
224
]
} |
among the neuroleptics tested , zotepine and haloperidol produced potent inhibitory effects on head-twitch induced by these three drugs . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
10,
22
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
45,
56
]
} |
further experimental evidence in rats suggest that such commonly used drugs as analgesic acetylsalicylic acid , antimalarial chloroquine phosphate and alcohol also alter the intestinal mucosal metabolism of estradiol and estrone sulphate and may thus alter the bioavailability of these estrogens . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial",
"pos": [
112,
124
]
} | {
"id": "C0055447",
"name": "chloroquine phosphate",
"pos": [
125,
146
]
} |
the results may be pertinent to the clinical impression that estrogens produce a partial resistance to the antidepressant efficacy of imipramine-like drugs . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
107,
121
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
134,
144
]
} |
it is demonstrated that this model is useful for studying new antiepileptic agents since a series of clinically effective drugs ( diazepam , clonazepam , na phenobarbital , primidone , carbamezepine , ethosuximide , diphenylhydantoin , na valproate , gabob ) show an activity which is does-dependent and within a range satisfactorily related to human dosages . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic agents",
"pos": [
62,
82
]
} | {
"id": "C0033148",
"name": "primidone",
"pos": [
173,
182
]
} |
it is demonstrated that this model is useful for studying new antiepileptic agents since a series of clinically effective drugs ( diazepam , clonazepam , na phenobarbital , primidone , carbamezepine , ethosuximide , diphenylhydantoin , na valproate , gabob ) show an activity which is does-dependent and within a range satisfactorily related to human dosages . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic agents",
"pos": [
62,
82
]
} | {
"id": "C0015043",
"name": "ethosuximide",
"pos": [
201,
213
]
} |
it is demonstrated that this model is useful for studying new antiepileptic agents since a series of clinically effective drugs ( diazepam , clonazepam , na phenobarbital , primidone , carbamezepine , ethosuximide , diphenylhydantoin , na valproate , gabob ) show an activity which is does-dependent and within a range satisfactorily related to human dosages . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic agents",
"pos": [
62,
82
]
} | {
"id": "C0031507",
"name": "diphenylhydantoin",
"pos": [
216,
233
]
} |
after nine months as an outpatient , during which time the patient was neuroleptic-free , she developed psychotic decompensation for which she was treated with thiothixene . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
71,
82
]
} | {
"id": "C0039955",
"name": "thiothixene",
"pos": [
160,
171
]
} |
sixty-three depressed women ( major depressive disorder ) and 21 paranoid-hallucinatory women have been studied while on antidepressant ( clomipramine ) or neuroleptic ( haloperidol ) treatment , respectively . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
121,
135
]
} | {
"id": "C0009010",
"name": "clomipramine",
"pos": [
138,
150
]
} |
sixty-three depressed women ( major depressive disorder ) and 21 paranoid-hallucinatory women have been studied while on antidepressant ( clomipramine ) or neuroleptic ( haloperidol ) treatment , respectively . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
156,
167
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
170,
181
]
} |
a significantly higher than expected number of spina bifida aperta were observed in this group , related to the administration to the mother of the anti-epileptic agent valproic acid . | therapeutic_class_of | {
"id": "C0003299",
"name": "anti-epileptic",
"pos": [
148,
162
]
} | {
"id": "C0042291",
"name": "valproic acid",
"pos": [
169,
182
]
} |
the anti-epileptic effect of gamma-vinyl-gaba ( gvg ) was studied using a placebo-controlled , single-blind design in 15 patients with therapy-resistant epilepsy , the majority experiencing complex partial seizures . | therapeutic_class_of | {
"id": "C0003299",
"name": "anti-epileptic",
"pos": [
4,
18
]
} | {
"id": "C0048044",
"name": "gamma-vinyl-gaba",
"pos": [
29,
45
]
} |
however , a 10-day trial with an antimicrobial agent , such as amoxicillin ( erythromycin and sulfonamide , trimethoprim-sulfamethoxazole , or cefaclor , are reasonable alternatives ) , should be prescribed before surgical intervention . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial",
"pos": [
33,
46
]
} | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
77,
89
]
} |
the recently synthesized depot neuroleptic haloperidol decanoate ( hd ) has been mainly used in the treatment of chronic schizophrenia . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
31,
42
]
} | {
"id": "C0062103",
"name": "haloperidol decanoate",
"pos": [
43,
64
]
} |
anti-rheumatic drugs such as d-penicillamine , dapsone and colchicine and the metal chelator 1,10 phenanthroline were all inactive on cell accumulation in this model . | therapeutic_class_of | {
"id": "C0003191",
"name": "anti-rheumatic drugs",
"pos": [
0,
20
]
} | {
"id": "C0030817",
"name": "penicillamine",
"pos": [
31,
44
]
} |
the cellular electrophysiologic effects of the following antiarrhythmic drugs are discussed : quinidine , procainamide , disopyramide , lidocaine , tocainide , mexiletine , phenytoin , beta-blocking and slow-channel-blocking drugs , aprindine , bretylium , ethmozin , and amiodarone . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
57,
71
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
94,
103
]
} |
the cellular electrophysiologic effects of the following antiarrhythmic drugs are discussed : quinidine , procainamide , disopyramide , lidocaine , tocainide , mexiletine , phenytoin , beta-blocking and slow-channel-blocking drugs , aprindine , bretylium , ethmozin , and amiodarone . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
57,
71
]
} | {
"id": "C0033216",
"name": "procainamide",
"pos": [
106,
118
]
} |
the cellular electrophysiologic effects of the following antiarrhythmic drugs are discussed : quinidine , procainamide , disopyramide , lidocaine , tocainide , mexiletine , phenytoin , beta-blocking and slow-channel-blocking drugs , aprindine , bretylium , ethmozin , and amiodarone . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
57,
71
]
} | {
"id": "C0012702",
"name": "disopyramide",
"pos": [
121,
133
]
} |
the cellular electrophysiologic effects of the following antiarrhythmic drugs are discussed : quinidine , procainamide , disopyramide , lidocaine , tocainide , mexiletine , phenytoin , beta-blocking and slow-channel-blocking drugs , aprindine , bretylium , ethmozin , and amiodarone . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
57,
71
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
136,
145
]
} |
the cellular electrophysiologic effects of the following antiarrhythmic drugs are discussed : quinidine , procainamide , disopyramide , lidocaine , tocainide , mexiletine , phenytoin , beta-blocking and slow-channel-blocking drugs , aprindine , bretylium , ethmozin , and amiodarone . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
57,
71
]
} | {
"id": "C0025887",
"name": "mexiletine",
"pos": [
160,
170
]
} |
the cellular electrophysiologic effects of the following antiarrhythmic drugs are discussed : quinidine , procainamide , disopyramide , lidocaine , tocainide , mexiletine , phenytoin , beta-blocking and slow-channel-blocking drugs , aprindine , bretylium , ethmozin , and amiodarone . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
57,
71
]
} | {
"id": "C0002598",
"name": "amiodarone",
"pos": [
272,
282
]
} |
the available data concerning amiodarone dosing may be summarized as follows : ( 1 ) there is an empirically demonstrated improvement in lag before onset of antiarrhythmic effect if amiodarone is given initially in large `` '' loading '' '' doses . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
157,
171
]
} | {
"id": "C0002598",
"name": "amiodarone",
"pos": [
182,
192
]
} |
effects of five antidepressant treatments -- clorgyline , desipramine hydrochloride , electroconvulsive treatment , lithium carbonate , and zimelidine hydrochloride -- on urinary outputs of dopamine , dihydroxyphenylacetic acid , and homovanillic acid ( hva ) were investigated in unipolar and bipolar depressed patients . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
16,
30
]
} | {
"id": "C0700529",
"name": "desipramine",
"pos": [
58,
69
]
} |
the neuroleptics aminazine , trifluoroperazine , haloperidol , the antidepressant imipramine in concentrations about 10 ( -4 ) m as well as the tranquilizers diazepam and phenazepam in concentrations about 10 ( -3 ) m completely depolarized synaptosomal membranes . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
4,
16
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
49,
60
]
} |
the neuroleptics aminazine , trifluoroperazine , haloperidol , the antidepressant imipramine in concentrations about 10 ( -4 ) m as well as the tranquilizers diazepam and phenazepam in concentrations about 10 ( -3 ) m completely depolarized synaptosomal membranes . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
67,
81
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
82,
92
]
} |
comparative study of antiarrhythmic properties of marcaine and lidocaine was made on aconitine- and strophanthine-induced experimental arrhythmias and in rhythm disorders induced by electrical stimulation of the ventricles . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
21,
35
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
63,
72
]
} |
of the study group , 106 children had been exposed to antiepileptic drugs ( 82 to phenytoin ) during pregnancy ; | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drugs",
"pos": [
54,
73
]
} | {
"id": "C0031507",
"name": "phenytoin",
"pos": [
82,
91
]
} |
the compounds were assayed in an in vitro system for antimalarial activity against chloroquine-susceptible and chloroquine-resistant strains of plasmodium falciparum . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial",
"pos": [
53,
65
]
} | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
111,
122
]
} |
this inhibitory effect was antagonized by antipsychotic drugs , the rank order of antagonistic potencies was sulpiride greater than haloperidol greater than clozapine ; | therapeutic_class_of | {
"id": "C0040615",
"name": "antipsychotic drugs",
"pos": [
42,
61
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
132,
143
]
} |
since most studies on the regulation of the [ 3h ] imipramine binding sites by antidepressants have used desipramine displaceable binding , which is heterogenous in nature and contains binding not related to 5-ht uptake sites , the present report studies the possible effects of chronic ( 3 weeks ) administration of imipramine or norzimeldine ( 10 mg/kg intraperitoneally twice daily ) on 5-ht sensitive [ 3h ] imipramine binding sites . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
79,
94
]
} | {
"id": "C0011685",
"name": "desipramine",
"pos": [
105,
116
]
} |
since most studies on the regulation of the [ 3h ] imipramine binding sites by antidepressants have used desipramine displaceable binding , which is heterogenous in nature and contains binding not related to 5-ht uptake sites , the present report studies the possible effects of chronic ( 3 weeks ) administration of imipramine or norzimeldine ( 10 mg/kg intraperitoneally twice daily ) on 5-ht sensitive [ 3h ] imipramine binding sites . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
79,
94
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
412,
422
]
} |
biochemical evidence that high concentrations of the antidepressant amoxapine may cause inhibition of mitochondrial electron transport . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
53,
67
]
} | {
"id": "C0002644",
"name": "amoxapine",
"pos": [
68,
77
]
} |
overdosage with the antidepressant amoxapine causes metabolic acidosis and may lead to brain damage and death . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
20,
34
]
} | {
"id": "C0002644",
"name": "amoxapine",
"pos": [
35,
44
]
} |
pirmenol hydrochloride is a promising antiarrhythmic agent with quinidine-like ( class ia ) properties presently undergoing evaluation . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agent",
"pos": [
38,
58
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
64,
73
]
} |
the results of this study , in conjunction with other toxicity and efficacy studies , have been utilized to select one of these compounds for development as a replacement for the antimalarial drug primaquine , and also to characterize the mhb-forming properties of wr 6026 . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial drug",
"pos": [
179,
196
]
} | {
"id": "C0033126",
"name": "primaquine",
"pos": [
197,
207
]
} |
we have briefly discussed the different methodologies available for measuring neuroleptic levels in plasma , their methodological weaknesses and strengths and some of the larger studies done with chlorpromazine , haloperidol and fluphenazine to establish correlations between levels , treatment response , oral dosages and side-effects . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
78,
89
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
213,
224
]
} |
all antidepressants examined , such as imipramine , clomipramine , amitriptyline , desipramine , mianserin and zimelidine inhibited a-cyclase in a dose dependent manner . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
4,
19
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
39,
49
]
} |
all antidepressants examined , such as imipramine , clomipramine , amitriptyline , desipramine , mianserin and zimelidine inhibited a-cyclase in a dose dependent manner . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
4,
19
]
} | {
"id": "C0009010",
"name": "clomipramine",
"pos": [
52,
64
]
} |
all antidepressants examined , such as imipramine , clomipramine , amitriptyline , desipramine , mianserin and zimelidine inhibited a-cyclase in a dose dependent manner . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
4,
19
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
67,
80
]
} |
all antidepressants examined , such as imipramine , clomipramine , amitriptyline , desipramine , mianserin and zimelidine inhibited a-cyclase in a dose dependent manner . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
4,
19
]
} | {
"id": "C0011685",
"name": "desipramine",
"pos": [
83,
94
]
} |
the effect of the new antiepileptic drug , vigabatrin ( gamma-vinyl gaba ) , on the platelet enzyme , gaba-aminotransferase ( gaba-t ) was investigated in volunteers and patients . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic",
"pos": [
22,
35
]
} | {
"id": "C0048044",
"name": "gamma-vinyl gaba",
"pos": [
56,
72
]
} |
effects of chronic oral administration of the antidepressants , desmethylimipramine and zimelidine on rat cortical gabab binding sites : a comparison with 5-ht2 binding site changes . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
46,
61
]
} | {
"id": "C0011685",
"name": "desmethylimipramine",
"pos": [
64,
83
]
} |
in vivo binding of [ 3h ] cv 205-502 was also dose-dependently blocked by other neuroleptics including sulpiride , haloperidol and spiroperidol , dopamine agonists such as bromocriptin , apomorphine and c1 201-678 but not by dopamine d1 antagonists or serotonin-2 antagonists . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
80,
92
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
115,
126
]
} |
hyperoxia significantly potentiated the antiarrhythmic effect of the drugs except lidocaine action in centrogenic arrhythmias . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
40,
54
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
82,
91
]
} |
mice exposed to 10 gy cobalt-60 radiation were given intramuscular antimicrobial therapy of gentamicin , or metronidazole , or a combination of the two . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial",
"pos": [
67,
80
]
} | {
"id": "C0025872",
"name": "metronidazole",
"pos": [
108,
121
]
} |
administration of the antifungal drug ketoconazole reduces serum 1,25-dihydroxyvitamin d ( 1,25-d ) levels in normal subjects . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
22,
32
]
} | {
"id": "C0022625",
"name": "ketoconazole",
"pos": [
38,
50
]
} |
the electrophysiologic effects and antiarrhythmic efficacy of flecainide were evaluated by electrophysiologic study ( eps ) in 20 patients with ventricular tachycardia ( vt ) refractory to an average 2.9 drugs . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
35,
49
]
} | {
"id": "C0016229",
"name": "flecainide",
"pos": [
62,
72
]
} |
in 19 patients epss were performed with patients not receiving antiarrhythmic medications and receiving oral flecainide therapy at steady state ( mean dose , 235 +/- 67 mg/day ) . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic medications",
"pos": [
63,
89
]
} | {
"id": "C0016229",
"name": "flecainide",
"pos": [
109,
119
]
} |
we studied the antiepileptic potency of vigabatrin ( gamma-vinyl gaba , gvg ) as an open trial in a group of 36 mentally handicapped patients with drug-resistant epilepsy ( 30 had seizures of partial onset and 6 had primary generalized [ pg ] tonic-clonic convulsions ) . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic",
"pos": [
15,
28
]
} | {
"id": "C0048044",
"name": "gamma-vinyl gaba",
"pos": [
53,
69
]
} |
[ comparative double-blind evaluation of a new topical antibacterial agent , mupirocin , compared with placebo in the treatment of skin and soft tissue infections ] . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
55,
68
]
} | {
"id": "C0085259",
"name": "mupirocin",
"pos": [
77,
86
]
} |
a number of newer antimicrobials have been introduced which offer potential in the therapy of acute bronchitis , including the enteric coated erythromycins , several new oral cephalosporins , and a large new class of drugs called the fluorinated quinolones . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobials",
"pos": [
18,
32
]
} | {
"id": "C0014806",
"name": "erythromycins",
"pos": [
142,
155
]
} |
thus , right ventricular ejection fraction ( rvef ) and left ventricular ejection fraction ( lvef ) and wall motion score ( wms ) were assessed in 14 patients with ventricular tachycardia before antiarrhythmic therapy , during mex and q monotherapies , and during combination therapy . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
195,
209
]
} | {
"id": "C0025887",
"name": "mex",
"pos": [
227,
230
]
} |
oral treatment with fluconazole resulted in much higher serum and extravascular concentrations of this antifungal agent than did comparable doses of ketoconazole . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal agent",
"pos": [
103,
119
]
} | {
"id": "C0022625",
"name": "ketoconazole",
"pos": [
149,
161
]
} |
the in vitro susceptibility of human isolates of pasteurella multocida to oral antimicrobial agents from our current study and from a review of the literature suggests that dicloxacillin ( oxacillin ) , erythromycin , clindamycin , cephalexin , cefaclor , and cefadroxil should not be used for empiric therapy of animal bite wounds . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial agents",
"pos": [
79,
99
]
} | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
203,
215
]
} |
ly163892 is a carbacephem antibiotic for oral administration with an antibacterial spectrum similar to that of cefaclor and amoxicillin-clavulanic acid . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
69,
82
]
} | {
"id": "C0007537",
"name": "cefaclor",
"pos": [
111,
119
]
} |
a prompt and sustained antiarrhythmic effect was obtained with an intravenous regimen of flecainide determined by a prospective pharmacokinetic approach . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
23,
37
]
} | {
"id": "C0016229",
"name": "flecainide",
"pos": [
89,
99
]
} |
the antiarrhythmic activity of flecainide acetate ( r-818 ) , 2 mg/kg , was investigated in anesthetized , open-chest pigs . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
4,
18
]
} | {
"id": "C0086303",
"name": "flecainide acetate",
"pos": [
31,
49
]
} |
antimicrobial sensitivity patterns showed all strains to be sensitive to chloromycetin , erythromycin , furoxone , gentamicin , nalidixic acid , neomycin , novobiocin , spectinomycin , and tetracycline . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial",
"pos": [
0,
13
]
} | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
89,
101
]
} |
antimicrobial sensitivity patterns showed all strains to be sensitive to chloromycetin , erythromycin , furoxone , gentamicin , nalidixic acid , neomycin , novobiocin , spectinomycin , and tetracycline . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial",
"pos": [
0,
13
]
} | {
"id": "C0039644",
"name": "tetracycline",
"pos": [
189,
201
]
} |
[ interaction between an antifungal heptaene , amphotericin b and cholesterol in vitro , as detected by circular dichroism and absorption . influence of temperature ] . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
25,
35
]
} | {
"id": "C0002679",
"name": "amphotericin b",
"pos": [
47,
61
]
} |
the na and 5-ht synapses are influenced to different degrees by the antidepressants : for example , desipramine has a preponderance of activity at na synapses and clomipramine at 5-ht synapses . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
68,
83
]
} | {
"id": "C0011685",
"name": "desipramine",
"pos": [
100,
111
]
} |
the na and 5-ht synapses are influenced to different degrees by the antidepressants : for example , desipramine has a preponderance of activity at na synapses and clomipramine at 5-ht synapses . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
68,
83
]
} | {
"id": "C0009010",
"name": "clomipramine",
"pos": [
163,
175
]
} |
after having tried several antiviral substances ( trifluorothymidine topically , adeninearabinoside-monophosphate intravenously , human leukocyte interferon intramuscularly and intracamerally ) we presently favour a topical combination therapy consisting of trifluorothymidine and steroids . | therapeutic_class_of | {
"id": "C0003451",
"name": "antiviral",
"pos": [
27,
36
]
} | {
"id": "C0040987",
"name": "trifluorothymidine",
"pos": [
258,
276
]
} |
on the basis of data from a variety of studies , the useful antibacterial spectrum of cefaclor is shown to include all classes of bacteria that are generally susceptible to cephalothin and cephalexin . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
60,
73
]
} | {
"id": "C0007537",
"name": "cefaclor",
"pos": [
86,
94
]
} |
on the basis of data from a variety of studies , the useful antibacterial spectrum of cefaclor is shown to include all classes of bacteria that are generally susceptible to cephalothin and cephalexin . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
60,
73
]
} | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
189,
199
]
} |
in rats anaesthetised with sodium pentobarbital the previous administration of a single dose of an anti-epileptic agent ( carbamazepine or sodium valproate ) significantly increases the curarising action of two short-action curare-like agents -- pancuronium bromide and fazadinium bromide . | therapeutic_class_of | {
"id": "C0003299",
"name": "anti-epileptic agent",
"pos": [
99,
119
]
} | {
"id": "C0037567",
"name": "sodium valproate",
"pos": [
139,
155
]
} |
in situations where ventricular anti-arrhythmic therapy is deemed necessary , especially if long-term use is considered , sotalol seems to be the agent of choice . | therapeutic_class_of | {
"id": "C0003195",
"name": "anti-arrhythmic",
"pos": [
32,
47
]
} | {
"id": "C0037707",
"name": "sotalol",
"pos": [
122,
129
]
} |
the antibacterial activity of cefaclor against 100 non-beta-lactamase producing and 11 beta-lactamase producing isolates of haemophilus influenzae was compared with that of cephalexin , ampicillin , chloramphenicol , tetracycline and co-trimoxazole . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0007537",
"name": "cefaclor",
"pos": [
30,
38
]
} |
the antibacterial activity of cefaclor against 100 non-beta-lactamase producing and 11 beta-lactamase producing isolates of haemophilus influenzae was compared with that of cephalexin , ampicillin , chloramphenicol , tetracycline and co-trimoxazole . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
173,
183
]
} |
the antibacterial activity of cefaclor against 100 non-beta-lactamase producing and 11 beta-lactamase producing isolates of haemophilus influenzae was compared with that of cephalexin , ampicillin , chloramphenicol , tetracycline and co-trimoxazole . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
186,
196
]
} |
the antibacterial activity of cefaclor against 100 non-beta-lactamase producing and 11 beta-lactamase producing isolates of haemophilus influenzae was compared with that of cephalexin , ampicillin , chloramphenicol , tetracycline and co-trimoxazole . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0008168",
"name": "chloramphenicol",
"pos": [
199,
214
]
} |
[ the antibacterial efficacy of cefaclor against bacteria resistant to ampicillin , tetracycline and co-trimoxazole ( author 's transl ) ] . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
6,
19
]
} | {
"id": "C0007537",
"name": "cefaclor",
"pos": [
32,
40
]
} |
[ the antibacterial efficacy of cefaclor against bacteria resistant to ampicillin , tetracycline and co-trimoxazole ( author 's transl ) ] . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
6,
19
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
71,
81
]
} |
the antibacterial activity of the new oral cephalosporin cefaclor was investigated using 623 freshly isolated bacterial strains . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0007537",
"name": "cefaclor",
"pos": [
57,
65
]
} |
[ the antibacterial efficacy of cefaclor in routine testing of clinical material from two berlin hospitals ( author 's transl ) ] . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
6,
19
]
} | {
"id": "C0007537",
"name": "cefaclor",
"pos": [
32,
40
]
} |
the agar diffusion method was used to test the antibacterial efficacy of cefaclor against bacterial strains isolated routinely from patients in two hospitals in berlin . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
47,
60
]
} | {
"id": "C0007537",
"name": "cefaclor",
"pos": [
73,
81
]
} |
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