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we treated three patients who had acanthamoeba keratitis with oral itraconazole , a new antifungal agent , topical miconazole , and surgical debridement of the lesion . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal agent",
"pos": [
88,
104
]
} | {
"id": "C0025942",
"name": "miconazole",
"pos": [
115,
125
]
} |
the antiarrhythmic efficacy of mexiletine hydrochloride ( mexitil ) was evaluated in 100 patients with potentially lethal and drug-resistant ventricular arrhythmia . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
4,
18
]
} | {
"id": "C0543459",
"name": "mexiletine hydrochloride",
"pos": [
31,
55
]
} |
it is concluded , that ncv generally is lowered under long term treatment with antiepileptic drugs and that phenytoin has no specific influence compared with the other drugs . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drugs",
"pos": [
79,
98
]
} | {
"id": "C0031507",
"name": "phenytoin",
"pos": [
108,
117
]
} |
the in-vitro activity of azithromycin against 60 clinical isolates of salmonella typhi was determined by broth microdilution and compared with eight macrolides , including erythromycin , and with other orally administered antimicrobial agents ( ampicillin , amoxycillin , cefaclor , trimethoprim/sulphamethoxazole , chloramphenicol , tetracycline , and ciprofloxacin ) . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial agents",
"pos": [
222,
242
]
} | {
"id": "C0039644",
"name": "tetracycline",
"pos": [
334,
346
]
} |
the in-vitro activity of azithromycin against 60 clinical isolates of salmonella typhi was determined by broth microdilution and compared with eight macrolides , including erythromycin , and with other orally administered antimicrobial agents ( ampicillin , amoxycillin , cefaclor , trimethoprim/sulphamethoxazole , chloramphenicol , tetracycline , and ciprofloxacin ) . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial agents",
"pos": [
222,
242
]
} | {
"id": "C0008809",
"name": "ciprofloxacin",
"pos": [
353,
366
]
} |
one hundred nine patients with recurrent episodes of symptomatic atrial fibrillation or flutter , or both , who had failed one to five previous antiarrhythmic drug trials were treated with propafenone and , subsequently , sotalol if atrial fibrillation recurred . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
144,
158
]
} | {
"id": "C0033429",
"name": "propafenone",
"pos": [
189,
200
]
} |
one hundred nine patients with recurrent episodes of symptomatic atrial fibrillation or flutter , or both , who had failed one to five previous antiarrhythmic drug trials were treated with propafenone and , subsequently , sotalol if atrial fibrillation recurred . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
144,
158
]
} | {
"id": "C0037707",
"name": "sotalol",
"pos": [
222,
229
]
} |
a possible mechanism of toxicity by the antidepressant amoxapine based on its effects in three in vitro models . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
40,
54
]
} | {
"id": "C0002644",
"name": "amoxapine",
"pos": [
55,
64
]
} |
when the antidepressant amoxapine is taken in overdose , it can cause metabolic acidosis , brain damage and sometimes death . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
9,
23
]
} | {
"id": "C0002644",
"name": "amoxapine",
"pos": [
24,
33
]
} |
these results may also help explain the reported potentiation by thyroid hormone of the antidepressant effects of imipramine . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
88,
102
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
114,
124
]
} |
the comparative antidepressant value of l-tryptophan and imipramine with and without attempted potentiation by liothyronine . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
16,
30
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
57,
67
]
} |
the antifungal imidazoles , ketoconazole and miconazole , were tested for effects on 25-hydroxyvitamin d3 metabolism in primary cultures of chick kidney cells . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
4,
14
]
} | {
"id": "C0022625",
"name": "ketoconazole",
"pos": [
28,
40
]
} |
the antifungal imidazoles , ketoconazole and miconazole , were tested for effects on 25-hydroxyvitamin d3 metabolism in primary cultures of chick kidney cells . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
4,
14
]
} | {
"id": "C0025942",
"name": "miconazole",
"pos": [
45,
55
]
} |
there seems to be a definite antimanic and a less expressed but indubitable antidepressant therapeutic effect of czp , and a considerable prophylactic effect in mania as well as depression , an effect which is possibly a little less than that of lithium . | therapeutic_class_of | {
"id": "C0242911",
"name": "antimanic",
"pos": [
29,
38
]
} | {
"id": "C0006949",
"name": "czp",
"pos": [
113,
116
]
} |
there seems to be a definite antimanic and a less expressed but indubitable antidepressant therapeutic effect of czp , and a considerable prophylactic effect in mania as well as depression , an effect which is possibly a little less than that of lithium . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
76,
90
]
} | {
"id": "C0006949",
"name": "czp",
"pos": [
113,
116
]
} |
all patients experienced documented sustained vt refractory to 4.1 +/- 2 antiarrhythmic agents per patient including amiodarone in 8 . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agents",
"pos": [
73,
94
]
} | {
"id": "C0002598",
"name": "amiodarone",
"pos": [
117,
127
]
} |
these results are unlike those produced by other beta-adrenergic blockers and suggest that the antiarrhythmic effects of sotalol are related primarily to its effect of action potential duration . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
95,
109
]
} | {
"id": "C0037707",
"name": "sotalol",
"pos": [
121,
128
]
} |
assays of antiepileptic drugs , caffeine , theophylline , tricyclic antidepressants , valproic acid , and meprobamate are used to demonstrate the importance of sample handlings in toxicological analyses in which reversed phase high performance liquid chromatographies are applied . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drugs",
"pos": [
10,
29
]
} | {
"id": "C0042291",
"name": "valproic acid",
"pos": [
86,
99
]
} |
the formerly designed method for quantitative evaluation of drug effects in rats is employed for the classification of three different neuroleptic drugs , namely sulpiride , clozapine and haloperidol . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
135,
146
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
188,
199
]
} |
the influence of antidepressants : nomifensine , imipramine , amitriptyline and trazodone on the effect of antiparkinsonian agents : trihexyphenidil and l-dopa + carbidopa mixture ( sinemet ) in the model of haloperidol catalepsy was investigated in rats . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
17,
32
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
49,
59
]
} |
the influence of antidepressants : nomifensine , imipramine , amitriptyline and trazodone on the effect of antiparkinsonian agents : trihexyphenidil and l-dopa + carbidopa mixture ( sinemet ) in the model of haloperidol catalepsy was investigated in rats . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
17,
32
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
62,
75
]
} |
several drugs are used for malaria chemoprophylaxis : 4 amino-quinolines , antifolics , combinations of sulfonamides and antifolics , and new anti-malarial agents , including mefloquine . | therapeutic_class_of | {
"id": "C0003374",
"name": "anti-malarial",
"pos": [
142,
155
]
} | {
"id": "C0025153",
"name": "mefloquine",
"pos": [
175,
185
]
} |
in high risk areas ( high incidence of resistant strains ) , no anti-malarial agent but the newly developed mefloquine is effective . | therapeutic_class_of | {
"id": "C0003374",
"name": "anti-malarial",
"pos": [
64,
77
]
} | {
"id": "C0025153",
"name": "mefloquine",
"pos": [
108,
118
]
} |
the potencies of various neuroleptic drugs ( zotepine , chlorpromazine-hcl , haloperidol and spiperone ) on serotonin1 ( 5ht1 ) receptors were examined in discrete rat brain regions using the radio receptor assay . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
25,
36
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
77,
88
]
} |
a color-reduction test by elisa was compared with the conventional plaque-reduction assay for its ability to measure the antiviral activity of acyclovir , bromovinyldeoxyuridine , trifluorothymidine , and vidarabine against four strains of varicella-zoster virus . | therapeutic_class_of | {
"id": "C0003451",
"name": "antiviral",
"pos": [
121,
130
]
} | {
"id": "C0040987",
"name": "trifluorothymidine",
"pos": [
180,
198
]
} |
interaction studies were carried out to investigate a possible synergistic action of the quinolones on the antifungal effect of amphotericin b . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
107,
117
]
} | {
"id": "C0002679",
"name": "amphotericin b",
"pos": [
128,
142
]
} |
in this study we have examined several forms of arrhythmias associated with mitral valve prolapse and discussed the antiarrhythmic therapy with quinidine , verapamil , amiodarone and propranolol . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
116,
130
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
144,
153
]
} |
in this study we have examined several forms of arrhythmias associated with mitral valve prolapse and discussed the antiarrhythmic therapy with quinidine , verapamil , amiodarone and propranolol . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
116,
130
]
} | {
"id": "C0002598",
"name": "amiodarone",
"pos": [
168,
178
]
} |
the effect of three antidepressant drugs , imipramine hydrochloride , clomipramine hydrochloride and zimelidine dihydrochloride on plasma free and total try concentrations has been examined . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
20,
34
]
} | {
"id": "C0589978",
"name": "imipramine hydrochloride",
"pos": [
43,
67
]
} |
the effect of three antidepressant drugs , imipramine hydrochloride , clomipramine hydrochloride and zimelidine dihydrochloride on plasma free and total try concentrations has been examined . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
20,
34
]
} | {
"id": "C0282107",
"name": "clomipramine",
"pos": [
70,
82
]
} |
it has been shown in experiments on rats of different age that antiarrhythmic activity of quinidine during aconitine and calcium chloride arrhythmias is mediated not only via the cardial mechanisms but also via the central nervous system , with the importance of these mechanisms in postnatal ontogenesis being inconclusive . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
63,
77
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
90,
99
]
} |
among the local antibacterial agents , the most common allergens were neomycin ( 32.9 % ) and bacitracin ( 12.3 % ) . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial agents",
"pos": [
16,
36
]
} | {
"id": "C0027603",
"name": "neomycin",
"pos": [
70,
78
]
} |
the effect of 2 prophylactic anthelmintic treatments with albendazole ( 7.5 mg/kg ) was evaluated in 2 groups of holstein dairy replacement heifers treated 3 and 6 weeks after turnout to spring pasture on may 2 , 1983 . | therapeutic_class_of | {
"id": "C0003158",
"name": "anthelmintic",
"pos": [
29,
41
]
} | {
"id": "C0001911",
"name": "albendazole",
"pos": [
58,
69
]
} |
corynebacterium group d2 strains were highly resistant to many antimicrobial agents but were highly susceptible to norfloxacin and vancomycin when tested at two phs ( 7.4 and 8.5 ) . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial",
"pos": [
63,
76
]
} | {
"id": "C0028365",
"name": "norfloxacin",
"pos": [
115,
126
]
} |
fourteen of these fetuses had supraventricular tachycardia and underwent in utero antiarrhythmic therapy with maternally administered digoxin either alone , or on combination with verapamil , propranolol , or procainamide . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
82,
96
]
} | {
"id": "C0033216",
"name": "procainamide",
"pos": [
209,
221
]
} |
the effects of the antiarrhythmic agent propafenone were evaluated in 25 patients with recurrent symptomatic ventricular tachycardia . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agent",
"pos": [
19,
39
]
} | {
"id": "C0033429",
"name": "propafenone",
"pos": [
40,
51
]
} |
reward-blocking doses of the neuroleptic pimozide activated the caudate and the lateral habenula but did not alter any of the unilateral effects of stimulation . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
29,
40
]
} | {
"id": "C0031935",
"name": "pimozide",
"pos": [
41,
49
]
} |
we studied the effect of six class i antiarrhythmic drugs , i.e. , quinidine ( 5 micrograms/ml ) , disopyramide ( 10 micrograms/ml ) , procainamide ( 30 micrograms/ml ) , flecainide ( 4 micrograms/ml ) , lidocaine ( 4 micrograms/ml ) and mexiletine ( 4 micrograms/ml ) , on the durations of the basic action potential ( apdb ) at a cycle length of 500 ms and on the premature apd ( apdt ) elicited at progressively increasing diastolic intervals ( di ) in canine purkinje fibers . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
37,
51
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
67,
76
]
} |
we studied the effect of six class i antiarrhythmic drugs , i.e. , quinidine ( 5 micrograms/ml ) , disopyramide ( 10 micrograms/ml ) , procainamide ( 30 micrograms/ml ) , flecainide ( 4 micrograms/ml ) , lidocaine ( 4 micrograms/ml ) and mexiletine ( 4 micrograms/ml ) , on the durations of the basic action potential ( apdb ) at a cycle length of 500 ms and on the premature apd ( apdt ) elicited at progressively increasing diastolic intervals ( di ) in canine purkinje fibers . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
37,
51
]
} | {
"id": "C0012702",
"name": "disopyramide",
"pos": [
99,
111
]
} |
we studied the effect of six class i antiarrhythmic drugs , i.e. , quinidine ( 5 micrograms/ml ) , disopyramide ( 10 micrograms/ml ) , procainamide ( 30 micrograms/ml ) , flecainide ( 4 micrograms/ml ) , lidocaine ( 4 micrograms/ml ) and mexiletine ( 4 micrograms/ml ) , on the durations of the basic action potential ( apdb ) at a cycle length of 500 ms and on the premature apd ( apdt ) elicited at progressively increasing diastolic intervals ( di ) in canine purkinje fibers . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
37,
51
]
} | {
"id": "C0033216",
"name": "procainamide",
"pos": [
135,
147
]
} |
we studied the effect of six class i antiarrhythmic drugs , i.e. , quinidine ( 5 micrograms/ml ) , disopyramide ( 10 micrograms/ml ) , procainamide ( 30 micrograms/ml ) , flecainide ( 4 micrograms/ml ) , lidocaine ( 4 micrograms/ml ) and mexiletine ( 4 micrograms/ml ) , on the durations of the basic action potential ( apdb ) at a cycle length of 500 ms and on the premature apd ( apdt ) elicited at progressively increasing diastolic intervals ( di ) in canine purkinje fibers . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
37,
51
]
} | {
"id": "C0016229",
"name": "flecainide",
"pos": [
171,
181
]
} |
we studied the effect of six class i antiarrhythmic drugs , i.e. , quinidine ( 5 micrograms/ml ) , disopyramide ( 10 micrograms/ml ) , procainamide ( 30 micrograms/ml ) , flecainide ( 4 micrograms/ml ) , lidocaine ( 4 micrograms/ml ) and mexiletine ( 4 micrograms/ml ) , on the durations of the basic action potential ( apdb ) at a cycle length of 500 ms and on the premature apd ( apdt ) elicited at progressively increasing diastolic intervals ( di ) in canine purkinje fibers . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
37,
51
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
204,
213
]
} |
we studied the effect of six class i antiarrhythmic drugs , i.e. , quinidine ( 5 micrograms/ml ) , disopyramide ( 10 micrograms/ml ) , procainamide ( 30 micrograms/ml ) , flecainide ( 4 micrograms/ml ) , lidocaine ( 4 micrograms/ml ) and mexiletine ( 4 micrograms/ml ) , on the durations of the basic action potential ( apdb ) at a cycle length of 500 ms and on the premature apd ( apdt ) elicited at progressively increasing diastolic intervals ( di ) in canine purkinje fibers . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
37,
51
]
} | {
"id": "C0025887",
"name": "mexiletine",
"pos": [
238,
248
]
} |
similarly , chronic but not acute treatment of rats with the antidepressants iprindole and imipramine resulted in a greater loss of 5-ht-induced inositol phospholipid hydrolysis than specific [ 3h ] ketanserin binding . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
61,
76
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
91,
101
]
} |
the effect of the antihelminthic substance praziquantel on the peptidergic nervous system in the adult gull-tapeworm diphyllobothrium dendriticum was tested . | therapeutic_class_of | {
"id": "C0003158",
"name": "antihelminthic",
"pos": [
18,
32
]
} | {
"id": "C0032911",
"name": "praziquantel",
"pos": [
43,
55
]
} |
guinea pigs and athymic nude ( rnu/rnu ) rats were used to assess the efficacy of three orally administered antifungal agents -- tolciclate , tolnaftate , and ketoconazole -- against trichophyton mentagrophytes dermatophytosis . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal agents",
"pos": [
108,
125
]
} | {
"id": "C0022625",
"name": "ketoconazole",
"pos": [
159,
171
]
} |
influence of acute , subchronic and chronic treatment with neuroleptic ( haloperidol ) on enkephalins and their precursors in the striatum of rat brain . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
59,
70
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
73,
84
]
} |
in an open prospective , randomized study of antimicrobial prophylaxis in colorectal surgery , using a single intravenous dose , metronidazole ( 1 g ) was more effective than doxycycline ( 0.2 g ) . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial",
"pos": [
45,
58
]
} | {
"id": "C0025872",
"name": "metronidazole",
"pos": [
129,
142
]
} |
to determine whether this effect of antiarrhythmic drugs is seen in humans , 14 patients undergoing atrial pacing at several rates were prospectively studied before and after the infusion of procainamide ( 15 mg/kg ) . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
36,
50
]
} | {
"id": "C0033216",
"name": "procainamide",
"pos": [
191,
203
]
} |
18 patients with myocardial infarction complicated by severe ventricular arrhythmias ( polymorphic vebs or bigeminy = 5 ; vt = 11 ; vf = 2 ) were treated with antiarrhythmics which were stopped after 24 hours ( intravenous infusion of mexiletine 0.5 mg/kg/hr after a loading dose ) . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmics",
"pos": [
159,
174
]
} | {
"id": "C0025887",
"name": "mexiletine",
"pos": [
235,
245
]
} |
we describe a reverse-phase high-pressure liquid chromatography method for the quantitation of a new quinoline carboxylic acid antimicrobial agent , ciprofloxacin ( bay o 9867 ) . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial agent",
"pos": [
127,
146
]
} | {
"id": "C0008809",
"name": "ciprofloxacin",
"pos": [
149,
162
]
} |
the in vitro antibacterial activities of ym-13115 , a new parenteral cephalosporin , were compared with those of ceftazidime , cefoperazone , and cefsulodin . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
13,
26
]
} | {
"id": "C0007559",
"name": "ceftazidime",
"pos": [
113,
124
]
} |
the in vitro antibacterial activities of ym-13115 , a new parenteral cephalosporin , were compared with those of ceftazidime , cefoperazone , and cefsulodin . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
13,
26
]
} | {
"id": "C0007552",
"name": "cefoperazone",
"pos": [
127,
139
]
} |
during 1983 , the antibacterial activity of ceftizoxime has been tested in vitro against 325 strains of enterobacteriaceae , streptococcaceae , micrococcaceae , pseudomonaceae and acinetobacter sp . isolated from material of human origin ( blood , urine , faeces , sputum , various exudates ) . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
18,
31
]
} | {
"id": "C0007560",
"name": "ceftizoxime",
"pos": [
44,
55
]
} |
we evaluated the hemodynamic effects of the class i antiarrhythmic flecainide in 20 patients within 18 hours of an acute myocardial infarction . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
52,
66
]
} | {
"id": "C0016229",
"name": "flecainide",
"pos": [
67,
77
]
} |
there was no difference between the groups in the plasma levels reached , which were within the recognized antiarrhythmic range for flecainide ( 200 to 1000 ng/ml ) throughout the infusion . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
107,
121
]
} | {
"id": "C0016229",
"name": "flecainide",
"pos": [
132,
142
]
} |
to test the effect of cimetidine on the kinetics of mexiletine , a class i antiarrhythmic similar to lidocaine , the absorption and disposition of mexiletine were followed in six healthy subjects before and after 1 week of cimetidine , 300 mg by mouth four times a day . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
75,
89
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
101,
110
]
} |
to test the effect of cimetidine on the kinetics of mexiletine , a class i antiarrhythmic similar to lidocaine , the absorption and disposition of mexiletine were followed in six healthy subjects before and after 1 week of cimetidine , 300 mg by mouth four times a day . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
75,
89
]
} | {
"id": "C0025887",
"name": "mexiletine",
"pos": [
147,
157
]
} |
alterations in microsomal drug metabolizing enzymes , microsomal lipids and some serum enzymes following pre-treatment of rats with therapeutic doses of four structurally different antimalarial compounds , chloroquine ( cq ) , quinine ( q ) , quinacrine ( qk ) and primaquine ( pq ) have been investigated . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial",
"pos": [
181,
193
]
} | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
206,
217
]
} |
alterations in microsomal drug metabolizing enzymes , microsomal lipids and some serum enzymes following pre-treatment of rats with therapeutic doses of four structurally different antimalarial compounds , chloroquine ( cq ) , quinine ( q ) , quinacrine ( qk ) and primaquine ( pq ) have been investigated . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial",
"pos": [
181,
193
]
} | {
"id": "C0033126",
"name": "primaquine",
"pos": [
265,
275
]
} |
two asymptomatic patients from a group of 30 being treated with the antiarrhythmic drug amiodarone developed roentgenographic pulmonary and pleural reactions . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drug",
"pos": [
68,
87
]
} | {
"id": "C0002598",
"name": "amiodarone",
"pos": [
88,
98
]
} |
two patients who developed ventricular arrhythmias were taking other antiarrhythmic agents , and in this series proarrhythmic effects occurred with both normal and high flecainide concentrations . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
69,
83
]
} | {
"id": "C0016229",
"name": "flecainide",
"pos": [
169,
179
]
} |
the objective of this study was to evaluate the haemodynamic and antiarrhythmic effects of flecainide acetate in patients with heart failure . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
65,
79
]
} | {
"id": "C0086303",
"name": "flecainide acetate",
"pos": [
91,
109
]
} |
a more detailed analysis of the children taking antiepileptic medication indicated that the only drug that significantly increased gaba in csf was valproic acid . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic medication",
"pos": [
48,
72
]
} | {
"id": "C0042291",
"name": "valproic acid",
"pos": [
147,
160
]
} |
the serum levels of total protein , albumin , aag and the protein binding of 2 antiarrhythmic drugs which are bases , disopyramide and flecainide , was measured in vitro with blood samples from eleven patients taken over the first 5 days following myocardial infarction . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drugs",
"pos": [
79,
99
]
} | {
"id": "C0012702",
"name": "disopyramide",
"pos": [
118,
130
]
} |
the serum levels of total protein , albumin , aag and the protein binding of 2 antiarrhythmic drugs which are bases , disopyramide and flecainide , was measured in vitro with blood samples from eleven patients taken over the first 5 days following myocardial infarction . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drugs",
"pos": [
79,
99
]
} | {
"id": "C0016229",
"name": "flecainide",
"pos": [
135,
145
]
} |
similarly , comparison with common antiepileptic drugs demonstrated that skf 100330-a and skf 89976-a were more potent than phenobarbital and valproic acid to block seizures in gerbils . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic",
"pos": [
35,
48
]
} | {
"id": "C0042291",
"name": "valproic acid",
"pos": [
142,
155
]
} |
[ antibacterial and antifungal agents . iv . synthesis and antifungal activity of econazole analogs with pyrrole structure ] . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
20,
30
]
} | {
"id": "C0013547",
"name": "econazole",
"pos": [
82,
91
]
} |
the synthesis of analogues of antifungal econazole with a pyrrole moiety starting from 1- ( 4-chlorophenyl ) -2- ( 1h-pyrrol-1-yl ) ethanone and from 1- ( 4-chlorophenyl ) -2- ( 1h-pyrrol-1-yl ) ethanol is described . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
30,
40
]
} | {
"id": "C0013547",
"name": "econazole",
"pos": [
41,
50
]
} |
the effect of oral administration of the antiarrhythmic disopyramide phosphate ( dpp ) on serum glucose and glucose counterregulation was determined in beagle dogs . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
41,
55
]
} | {
"id": "C0700534",
"name": "disopyramide phosphate",
"pos": [
56,
78
]
} |
the new method has been tested both retrospectively on 102 patients treated with different antiarrhythmic drugs and prospectively on 12 patients subjected to three consecutive control ambulatory electrocardiograms and to a fourth one after treatment with propafenone . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drugs",
"pos": [
91,
111
]
} | {
"id": "C0033429",
"name": "propafenone",
"pos": [
255,
266
]
} |
[ comparative antibacterial activity of piperacillin against pseudomonas aeruginosa , escherichia coli and streptococcus faecalis in cultures and human serum ] . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
14,
27
]
} | {
"id": "C0031955",
"name": "piperacillin",
"pos": [
40,
52
]
} |
6315-s shows good antibacterial activity against gram-positive and gram-negative bacteria , being especially highly active against clinical isolates of staphylococcus aureus resistant to either ampicillin or methicillin . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
18,
31
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
194,
204
]
} |
thus , of the four most commonly used antiseptics , povidone-iodine , when diluted 1:100 , was the most rapidly bactericidal against both mrsa and methicillin-susceptible s. aureus . | therapeutic_class_of | {
"id": "C0003205",
"name": "antiseptics",
"pos": [
38,
49
]
} | {
"id": "C0032857",
"name": "povidone-iodine",
"pos": [
52,
67
]
} |
comparison of antiarrhythmic effects of oral prajmalium bitartrate and intravenous lidocaine in acute myocardial infarction . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
14,
28
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
83,
92
]
} |
lambs naturally infected with thysanosoma actinioides and naturally and experimentally infected with haemonchus contortus were used in a controlled experiment to determine the anthelmintic activity of albendazole as compared with levamisole . | therapeutic_class_of | {
"id": "C0003158",
"name": "anthelmintic",
"pos": [
176,
188
]
} | {
"id": "C0001911",
"name": "albendazole",
"pos": [
201,
212
]
} |
the effectiveness of the antidepressant agents 8-amino-1,2,3,4-tetrahydro-2-methyl-4-phenyl-isoquinoline ( nomifensine , alival ) and amitriptyline on various ulcer models was tested by using at least 300 rats . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant agents",
"pos": [
25,
46
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
134,
147
]
} |
the effects of a new antiarrhythmic , bunaphtine , on the electrical and mechanical activity of isolated rat atria were compared with those of quinidine and amiodarone . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
21,
35
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
143,
152
]
} |
the effects of a new antiarrhythmic , bunaphtine , on the electrical and mechanical activity of isolated rat atria were compared with those of quinidine and amiodarone . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
21,
35
]
} | {
"id": "C0002598",
"name": "amiodarone",
"pos": [
157,
167
]
} |
we have attempted to apply the procedure for securing data for `` '' mutational synergism '' '' between ultraviolet ( uv ) radiation and a number of antimalarial drugs including quinine hydrochloride ( 50 microgram/ml ) , quinine hydrobromide ( 50 microgram/ml ) , primaquine diphosphate ( 50 microgram/ml ) , chloroquine ( 50 microgram/ml ) , quinine ( 50 microgram/ml ) and quinacrine dihydrochloride ( 25 microgram/ml ) . | therapeutic_class_of | {
"id": "C0003374",
"name": "f antimalari",
"pos": [
147,
159
]
} | {
"id": "C0008269",
"name": ", chloroqui",
"pos": [
308,
319
]
} |
the dwarf tapeworm , hymenolepis nana , was studied by means of scanning and transmission electron microscopy after in vitro exposure to 1 , 10 , and 100 micrograms/ml of the anthelmintic praziquantel ( droncit ) for 5 , 15 , 30 , and 60 min . | therapeutic_class_of | {
"id": "C0003158",
"name": "anthelmintic",
"pos": [
175,
187
]
} | {
"id": "C0032911",
"name": "praziquantel",
"pos": [
188,
200
]
} |
in two trials mexiletine was compared with other antiarrhythmic drugs ( atenolol , disopyramide , lorcainide ) and placebo . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drugs",
"pos": [
49,
69
]
} | {
"id": "C0012702",
"name": "disopyramide",
"pos": [
83,
95
]
} |
the opiatelike neuropeptide beta-endorphin produces a spectrum of effects that contrasts with that induced by the neuroleptic haloperidol . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
114,
125
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
126,
137
]
} |
the antibacterial activity of ampicillin was preliminarily tested on 517 microbial strains , i.e . staphylococci , streptococci , e. coli , proteus and ps . aeruginosa isolated from the surgical patients . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
30,
40
]
} |
trimethoprim had no antibacterial effect on the pseudomonas strains and did not alter amikacin 's activity against these bacteria . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
20,
33
]
} | {
"id": "C0002499",
"name": "amikacin 's",
"pos": [
86,
97
]
} |
the in vitro antibacterial activity of cefaclor , cephalothin , and cephalexin against 261 clinical isolates of staphylococcus aureus and enterobacteriaceae was compared . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
13,
26
]
} | {
"id": "C0007537",
"name": "cefaclor",
"pos": [
39,
47
]
} |
the in vitro antibacterial activity of cefaclor , cephalothin , and cephalexin against 261 clinical isolates of staphylococcus aureus and enterobacteriaceae was compared . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
13,
26
]
} | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
68,
78
]
} |
thioridazine and the classical neuroleptics haloperidol and chlorpromazine were included in the study for comparison . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
31,
43
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
44,
55
]
} |
in a double-blind clinical trialnomifensine was compared with a standard and widely tested antidepressant amitriptyline . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
91,
105
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
106,
119
]
} |
the in vitro antifungal activities of amphotericin b ( amb ) and amphotericin b methyl ester ( ame ) were compared against 465 clinical isolates of candida albicans . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
13,
23
]
} | {
"id": "C0002679",
"name": "amphotericin b",
"pos": [
65,
79
]
} |
in vivo antibacterial activities of t-1220 , ampicillin ( ab-pc ) , and cb-pc were compared , using systemic infections of mice with p. aeruginosa , k. pneumoniae , and escherichia coli . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
8,
21
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
45,
55
]
} |
in vivo antibacterial activities of t-1220 , ampicillin ( ab-pc ) , and cb-pc were compared , using systemic infections of mice with p. aeruginosa , k. pneumoniae , and escherichia coli . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
8,
21
]
} | {
"id": "C0006976",
"name": "cb-pc",
"pos": [
72,
77
]
} |
as the antifungal activity of ame is comparable to that of amb by testing in vitro , further study is warranted . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
7,
17
]
} | {
"id": "C0002679",
"name": "amb",
"pos": [
59,
62
]
} |
in agar , cefaclor had greater antibacterial activity than either cephalexin or cephradine against isolates of escherichia coli , proteus mirabilis , staphylococcus aureus , klebsiella pneumoniae , and salmonella typhi . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
31,
44
]
} | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
66,
76
]
} |
in agar , cefaclor had greater antibacterial activity than either cephalexin or cephradine against isolates of escherichia coli , proteus mirabilis , staphylococcus aureus , klebsiella pneumoniae , and salmonella typhi . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
31,
44
]
} | {
"id": "C0007738",
"name": "cephradine",
"pos": [
80,
90
]
} |
from the data obtained in this in vitro study , it can be concluded that cefaclor , which has a substituted chloro group attached to the molecule , had increased antibacterial activity over cephalexin and cephradine . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
162,
175
]
} | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
190,
200
]
} |
from the data obtained in this in vitro study , it can be concluded that cefaclor , which has a substituted chloro group attached to the molecule , had increased antibacterial activity over cephalexin and cephradine . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
162,
175
]
} | {
"id": "C0007738",
"name": "cephradine",
"pos": [
205,
215
]
} |
the antidepressant characteristics of three indole alkylamines were investigated and compared with phenelzine and imipramine by utilising specific pharmacological tools like reserpine , amphetamine , tryptamine and tetrabenazine for determining their possible mechanism of action . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
4,
18
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
114,
124
]
} |
the activity of carfecillin in antibacterial tests in vitro depends upon the extent of hydrolysis to carbenicillin , and in conventional serial dilution tests carfecillin shows an antibacterial spectrum generally similar to that of carbenicillin due to extensive hydrolysis . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
31,
44
]
} | {
"id": "C0006976",
"name": "carbenicillin",
"pos": [
232,
245
]
} |
[ use of ajmaline in the therapy of various heart arrhythmias and comparison with the classic antiarrhythmic drug quinidine ] . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drug",
"pos": [
94,
113
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
114,
123
]
} |
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