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we examined the antibacterial activity of penicillin g potassium , 100 microgram/ml , cefazolin sodium , 100 microgram/ml , and gentamicin sulfate , 20 microgram/ml against test organisms in m-k medium at 4 degrees , 23 degrees , and 37 degrees c for periods up to 18 hours . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
16,
29
]
} | {
"id": "C0546866",
"name": "gentamicin sulfate",
"pos": [
128,
146
]
} |
the anti-arrhythmic effect of oral mexiletine on exercise-induced ventricular arrhythmia was studied in a double blind trial of 10 patients suffering from ventricular ectopic beats of different origins . | therapeutic_class_of | {
"id": "C0003195",
"name": "anti-arrhythmic",
"pos": [
4,
19
]
} | {
"id": "C0025887",
"name": "mexiletine",
"pos": [
35,
45
]
} |
however , application of membrane-interacting agents like tris ( hydroxymethyl ) aminomethane ( tris ) -hydrochloride , ethylenediaminetetraacetate ( na salt ) ( edta ) , divalent cations , and sublethal doses of the cationic antibacterial agents polymyxin b and chlorhexidine induced specific fluorescent labeling of envelope proteins and lipids but not of cytoplasmic compounds , with the exception of a soluble protein with a molecular weight of 46,000 in sodium dodecyl sulfate-polyacrylamide gel electrophoresis . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial agents",
"pos": [
226,
246
]
} | {
"id": "C0032535",
"name": "polymyxin b",
"pos": [
247,
258
]
} |
antifungal activity of four tetracycline analogues against candida albicans in vitro : potentiation by amphotericin b . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
0,
10
]
} | {
"id": "C0002679",
"name": "amphotericin b",
"pos": [
103,
117
]
} |
the antifungal activities of four tetracycline analogues in combination with amphotericin b ( amb ) were determined against 20 strains of candida albicans . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
4,
14
]
} | {
"id": "C0002679",
"name": "amphotericin b",
"pos": [
77,
91
]
} |
the antiepileptic drugs phenobarbital and phenytoin were determined in serum by enzyme immunoassay ( emit , syva corp. ) and gas-liquid chromatography . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drugs",
"pos": [
4,
23
]
} | {
"id": "C0031507",
"name": "phenytoin",
"pos": [
42,
51
]
} |
a unifying molecular model for the interaction of antiarrhythmic drugs with cardiac sodium channels : application to quinidine and lidocaine . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drugs",
"pos": [
50,
70
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
117,
126
]
} |
a unifying molecular model for the interaction of antiarrhythmic drugs with cardiac sodium channels : application to quinidine and lidocaine . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drugs",
"pos": [
50,
70
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
131,
140
]
} |
dose-response curves were established for the blockade of icss by the antipsychotic drugs chlorpromazine , thioridazine , clozapine , and pimozide and the alpha-antagonist phenoxybenzamine . | therapeutic_class_of | {
"id": "C0040615",
"name": "antipsychotic drugs",
"pos": [
70,
89
]
} | {
"id": "C0031935",
"name": "pimozide",
"pos": [
138,
146
]
} |
the combination of trimethoprim + sulfametrole ( 1 + 20 ) had the same antibacterial activity as the combination co-trimoxazole = trimethoprim + nd- ( 5-methyl-3-isoxazolyl ) -sulfanilamide ( sulfamethoxazole ; smz ) . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
71,
84
]
} | {
"id": "C0041041",
"name": "trimethoprim",
"pos": [
130,
142
]
} |
antibacterial activity of ticarcillin , tobramycin and gentamicin alone and in combination against pseudomonas aeruginosa in vitro . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
0,
13
]
} | {
"id": "C0040193",
"name": "ticarcillin",
"pos": [
26,
37
]
} |
antibacterial activity of ticarcillin , tobramycin and gentamicin alone and in combination against pseudomonas aeruginosa in vitro . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
0,
13
]
} | {
"id": "C0040341",
"name": "tobramycin",
"pos": [
40,
50
]
} |
a new antiarrhythmic drug ch-200 , 5-phenacyl-thieno [ 3,2-c ] yridinium , was compared with procainamide and lidocaine in a two-stage coronary ligation arrhythmia model for its efficacy and electrophysiological properties . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drug",
"pos": [
6,
25
]
} | {
"id": "C0033216",
"name": "procainamide",
"pos": [
93,
105
]
} |
a new antiarrhythmic drug ch-200 , 5-phenacyl-thieno [ 3,2-c ] yridinium , was compared with procainamide and lidocaine in a two-stage coronary ligation arrhythmia model for its efficacy and electrophysiological properties . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drug",
"pos": [
6,
25
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
110,
119
]
} |
the antiarrhythmic effects of ch-200 and procainamide developed slowly and lasted longer than those of lidocaine . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
4,
18
]
} | {
"id": "C0033216",
"name": "procainamide",
"pos": [
41,
53
]
} |
the antiarrhythmic effects of ch-200 and procainamide developed slowly and lasted longer than those of lidocaine . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
4,
18
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
103,
112
]
} |
the antibacterial spectrum of vancomycin also covers other gram-positive cocci and bacteria and gram-negative cocci . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0042313",
"name": "vancomycin",
"pos": [
30,
40
]
} |
in a double-blind , controlled study 158 outpatients with unipolar depression were treated for six weeks with amoxapine , imipramine , or placebo to assess the antidepressant effects of the new dibenzooxazepine compound , amoxapine . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
160,
174
]
} | {
"id": "C0002644",
"name": "amoxapine",
"pos": [
222,
231
]
} |
in 12 patients no antiarrhythmic regimen was completely suppressive and in 7 of these mexiletine favorably modified the response to programmed stimulation . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
18,
32
]
} | {
"id": "C0025887",
"name": "mexiletine",
"pos": [
86,
96
]
} |
twelve patients completed a double-blind , crossover antiarrhythmic drug trial in which 300 mg of quinidine , 500 mg of procainamide , 100 mg of phenytoin , or placebo was given four times daily on subsequent weeks . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drug",
"pos": [
53,
72
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
98,
107
]
} |
twelve patients completed a double-blind , crossover antiarrhythmic drug trial in which 300 mg of quinidine , 500 mg of procainamide , 100 mg of phenytoin , or placebo was given four times daily on subsequent weeks . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drug",
"pos": [
53,
72
]
} | {
"id": "C0033216",
"name": "procainamide",
"pos": [
120,
132
]
} |
no antiarrhythmic agent demonstrated a significant overall reduction in the number of pvcs , but both quinidine and procainamide showed a statistically significant ( p less than 0.05 ) reduction of pvcs with coupling intervals less than 400 msec . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agent",
"pos": [
3,
23
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
102,
111
]
} |
no antiarrhythmic agent demonstrated a significant overall reduction in the number of pvcs , but both quinidine and procainamide showed a statistically significant ( p less than 0.05 ) reduction of pvcs with coupling intervals less than 400 msec . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agent",
"pos": [
3,
23
]
} | {
"id": "C0033216",
"name": "procainamide",
"pos": [
116,
128
]
} |
as 2-hydroxy-desipramine may possess antidepressant activity , future studies designed to assess the therapeutic effect of desipramine should account for the presence of its pharmacologically active metabolite . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
37,
51
]
} | {
"id": "C0011685",
"name": "desipramine",
"pos": [
123,
134
]
} |
dopamine-stimulated adenylate cyclase activity was potently antagonised by various neuroleptic drugs including fluphenazine , alpha-flupenthixol and alpha-piflutixol , and to a lesser extent by the butyrophenone derivatives haloperidol and spiperone . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic drugs",
"pos": [
83,
100
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
224,
235
]
} |
a group ( n = 6 ) that received the classical conditioning sessions while under the influence of the neuroleptic , pimozide ( 1.0 mg/kg , ip ) also showed enhanced acquisition of the discrimination when tested while undrugged but their performance was intermediate between that of the other groups for the first seven sessions . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
101,
112
]
} | {
"id": "C0031935",
"name": "pimozide",
"pos": [
115,
123
]
} |
classical antipsychotic drugs such as haloperidol produce akinesia and catalepsy , whereas clozapine and related atypical antipsychotics fail to elicit these behaviors even at relatively high doses . | therapeutic_class_of | {
"id": "C0040615",
"name": "antipsychotic drugs",
"pos": [
10,
29
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
38,
49
]
} |
the authors treated 16 outpatients and 1 inpatient who had diagnoses of schizophrenia in exacerbation with haloperidol as the sole neuroleptic agent and obtained ratings of psychopathology and serum levels of haloperidol . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic agent",
"pos": [
131,
148
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
209,
220
]
} |
these included peak serum creatine kinase , location of infarction , incidence of pericarditis , use of antiinflammatory drugs ( aspirin and indomethacin ) or membrane-active antiarrhythmic drugs ( lidocaine and procainamide ) , peripheral leukocyte count and cell labeling efficiency . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drugs",
"pos": [
175,
195
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
198,
207
]
} |
these included peak serum creatine kinase , location of infarction , incidence of pericarditis , use of antiinflammatory drugs ( aspirin and indomethacin ) or membrane-active antiarrhythmic drugs ( lidocaine and procainamide ) , peripheral leukocyte count and cell labeling efficiency . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drugs",
"pos": [
175,
195
]
} | {
"id": "C0033216",
"name": "procainamide",
"pos": [
212,
224
]
} |
toward a biochemical classification of depressive disorders iv : pretreatment urinary mhpg levels as predictors of antidepressant response to imipramine . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
115,
129
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
142,
152
]
} |
the bacterial isolates were resistant to all commonly used antibacterial agents but showed good sensitivity to vancomycin and rifampicin . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial agents",
"pos": [
59,
79
]
} | {
"id": "C0042313",
"name": "vancomycin",
"pos": [
111,
121
]
} |
the bacterial isolates were resistant to all commonly used antibacterial agents but showed good sensitivity to vancomycin and rifampicin . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial agents",
"pos": [
59,
79
]
} | {
"id": "C0035608",
"name": "rifampicin",
"pos": [
126,
136
]
} |
the antibacterial activities of k-4619 ( 3-de-o-methylsporaricin a sulfate ) were compared with those of sporaricin a , amikacin , dibekacin , and gentamicin . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0002499",
"name": "amikacin",
"pos": [
120,
128
]
} |
both proguanil and pbg exhibited weak antimalarial activity in vitro , but inhibitory blood levels of either compound are unlikely to occur after a normal human dose of proguanil . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial",
"pos": [
38,
50
]
} | {
"id": "C0008241",
"name": "proguanil",
"pos": [
169,
178
]
} |
the transfer of the antiepileptic drug valproic acid ( 2-propyl-pentenoic acid ) and one of its active metabolites , 2-en ( 2-propyl-2-pentenoic acid ) from plasma to brain and liver were studied in mice at low dose levels ( 0.1 , 0.3 , 0.7 , and 1.0 mmole/kg ) . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drug",
"pos": [
20,
38
]
} | {
"id": "C0042291",
"name": "valproic acid",
"pos": [
39,
52
]
} |
blood ethanol concentrations were not influenced by the co-administration of either antidepressant . tmax for trazodone was prolonged by ethanol but the other pharmacokinetic parameters for trazodone and amitriptyline were not influenced by ethanol . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
84,
98
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
204,
217
]
} |
the antifibrillatory drug bretylium and the antiepileptic drug diphenylhydantoin cause an increase in the potential different and in the short-circuit current ( scc ) across frog skin when added to the outer surface . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drug",
"pos": [
44,
62
]
} | {
"id": "C0031507",
"name": "diphenylhydantoin",
"pos": [
63,
80
]
} |
this was associated with widespread use in the urban community of antimalarial drugs , particularly chloroquine , as prophylaxis . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial",
"pos": [
66,
78
]
} | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
100,
111
]
} |
in this efficient extraction and isocratic liquid-chromatographic procedure for measuring eight antidepressant drugs in serum ( amoxapine , 8-hydroxyamoxapine , doxepin , desmethyldoxepin , imipramine , desipramine , amitriptyline , and nortriptyline ) , they are extracted from serum as a group by use of disposable solid-phase cyanopropyl columns ; | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant drugs",
"pos": [
96,
116
]
} | {
"id": "C0002644",
"name": "amoxapine",
"pos": [
149,
158
]
} |
in this efficient extraction and isocratic liquid-chromatographic procedure for measuring eight antidepressant drugs in serum ( amoxapine , 8-hydroxyamoxapine , doxepin , desmethyldoxepin , imipramine , desipramine , amitriptyline , and nortriptyline ) , they are extracted from serum as a group by use of disposable solid-phase cyanopropyl columns ; | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant drugs",
"pos": [
96,
116
]
} | {
"id": "C0013085",
"name": "doxepin",
"pos": [
180,
187
]
} |
in this efficient extraction and isocratic liquid-chromatographic procedure for measuring eight antidepressant drugs in serum ( amoxapine , 8-hydroxyamoxapine , doxepin , desmethyldoxepin , imipramine , desipramine , amitriptyline , and nortriptyline ) , they are extracted from serum as a group by use of disposable solid-phase cyanopropyl columns ; | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant drugs",
"pos": [
96,
116
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
190,
200
]
} |
in this efficient extraction and isocratic liquid-chromatographic procedure for measuring eight antidepressant drugs in serum ( amoxapine , 8-hydroxyamoxapine , doxepin , desmethyldoxepin , imipramine , desipramine , amitriptyline , and nortriptyline ) , they are extracted from serum as a group by use of disposable solid-phase cyanopropyl columns ; | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant drugs",
"pos": [
96,
116
]
} | {
"id": "C0011685",
"name": "desipramine",
"pos": [
203,
214
]
} |
in this efficient extraction and isocratic liquid-chromatographic procedure for measuring eight antidepressant drugs in serum ( amoxapine , 8-hydroxyamoxapine , doxepin , desmethyldoxepin , imipramine , desipramine , amitriptyline , and nortriptyline ) , they are extracted from serum as a group by use of disposable solid-phase cyanopropyl columns ; | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant drugs",
"pos": [
96,
116
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
217,
230
]
} |
in this efficient extraction and isocratic liquid-chromatographic procedure for measuring eight antidepressant drugs in serum ( amoxapine , 8-hydroxyamoxapine , doxepin , desmethyldoxepin , imipramine , desipramine , amitriptyline , and nortriptyline ) , they are extracted from serum as a group by use of disposable solid-phase cyanopropyl columns ; | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant drugs",
"pos": [
96,
116
]
} | {
"id": "C0028420",
"name": "nortriptyline",
"pos": [
237,
250
]
} |
the antibacterial activity of ciprofloxacin was compared to those of norfloxacin , pefloxacin , pipemidic acid , nalidixic acid , nitrofurantoin , sulfamethoxazole , trimethoprim , cephradine and amoxycillin . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0028156",
"name": "nitrofurantoin",
"pos": [
130,
144
]
} |
the antibacterial activity of ciprofloxacin was compared to those of norfloxacin , pefloxacin , pipemidic acid , nalidixic acid , nitrofurantoin , sulfamethoxazole , trimethoprim , cephradine and amoxycillin . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0041041",
"name": "trimethoprim",
"pos": [
166,
178
]
} |
the antibacterial activity of ciprofloxacin was compared to those of norfloxacin , pefloxacin , pipemidic acid , nalidixic acid , nitrofurantoin , sulfamethoxazole , trimethoprim , cephradine and amoxycillin . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0007738",
"name": "cephradine",
"pos": [
181,
191
]
} |
the antibacterial activity of ciprofloxacin was compared to those of norfloxacin , pefloxacin , pipemidic acid , nalidixic acid , nitrofurantoin , sulfamethoxazole , trimethoprim , cephradine and amoxycillin . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0002645",
"name": "amoxycillin",
"pos": [
196,
207
]
} |
the antibacterial activity of ciprofloxacin ( bay o 9867 ) was compared with those of norfloxacin , nalidixic acid , trimethoprim-sulfamethoxazole , cefaclor , sisomicin and cefotaxime in in vitro and mouse protection studies . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0007537",
"name": "cefaclor",
"pos": [
149,
157
]
} |
the antibacterial activity of ciprofloxacin ( bay o 9867 ) was compared with those of norfloxacin , nalidixic acid , trimethoprim-sulfamethoxazole , cefaclor , sisomicin and cefotaxime in in vitro and mouse protection studies . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
174,
184
]
} |
for comparison the following neuroleptics of different chemical classes were incorporated in our investigations : ( + ) -bulbocapnine , clozapine , chlorpromazine , cis-flupenthixol , ( - ) -sulpiride and haloperidol . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
29,
41
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
205,
216
]
} |
[ induction of monocytic-myelocytic mixed cell leukemias after the application of the neuroleptic haloperidol in mice ] . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
86,
97
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
98,
109
]
} |
except for sulpiride and carpipramine , the neuroleptic drugs chlorpromazine , thioridazine , perphenazine , haloperidol , floropipamide , pimozide , clocapramine and oxypertine all suppressed self-stimulation behavior dose-dependently . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic drugs",
"pos": [
44,
61
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
109,
120
]
} |
except for sulpiride and carpipramine , the neuroleptic drugs chlorpromazine , thioridazine , perphenazine , haloperidol , floropipamide , pimozide , clocapramine and oxypertine all suppressed self-stimulation behavior dose-dependently . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic drugs",
"pos": [
44,
61
]
} | {
"id": "C0031935",
"name": "pimozide",
"pos": [
139,
147
]
} |
the antidepressant drugs imipramine and amitriptyline suppressed this behavior slightly at the dose of 40 mg/kg . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant drugs",
"pos": [
4,
24
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
25,
35
]
} |
the antidepressant drugs imipramine and amitriptyline suppressed this behavior slightly at the dose of 40 mg/kg . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant drugs",
"pos": [
4,
24
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
40,
53
]
} |
[ antibacterial activity of clindamycin and lincomycin in broth , serum , and in combination with polymorphonuclear leukocytes against staphylococcus aureus and staphylococcus epidermidis ] . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
2,
15
]
} | {
"id": "C0008947",
"name": "clindamycin",
"pos": [
28,
39
]
} |
we investigated the antibacterial activity of clindamycin and lincomycin at 1/4 x minimum inhibitory concentration ( mic ) , 1 x mic and 4 x mic against a serum-resistant staphylococcus aureus and a serum-resistant staphylococcus epidermidis strain in broth , in serum with and without the presence of leukocytes and in hank 's medium in combination with leukocytes alone . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
20,
33
]
} | {
"id": "C0008947",
"name": "clindamycin",
"pos": [
46,
57
]
} |
the in vitro antibacterial activity of fosfomycin was compared to that of oxacillin , cefazolin , ceftriaxone and vancomycin against isolates of staphylococcus aureus from patients treated at the university of vienna general hospital . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
13,
26
]
} | {
"id": "C0029983",
"name": "oxacillin",
"pos": [
74,
83
]
} |
the in vitro antibacterial activity of fosfomycin was compared to that of oxacillin , cefazolin , ceftriaxone and vancomycin against isolates of staphylococcus aureus from patients treated at the university of vienna general hospital . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
13,
26
]
} | {
"id": "C0007546",
"name": "cefazolin",
"pos": [
86,
95
]
} |
the in vitro antibacterial activity of fosfomycin was compared to that of oxacillin , cefazolin , ceftriaxone and vancomycin against isolates of staphylococcus aureus from patients treated at the university of vienna general hospital . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
13,
26
]
} | {
"id": "C0007561",
"name": "ceftriaxone",
"pos": [
98,
109
]
} |
the in vitro antibacterial activity of fosfomycin was compared to that of oxacillin , cefazolin , ceftriaxone and vancomycin against isolates of staphylococcus aureus from patients treated at the university of vienna general hospital . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
13,
26
]
} | {
"id": "C0042313",
"name": "vancomycin",
"pos": [
114,
124
]
} |
dothiepin thus was found to be an effective antidepressant drug associated with fewer side effects than amitriptyline in the treatment of depressed outpatients . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
44,
58
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
104,
117
]
} |
the effects of neuroleptics ( haloperidol and chlorpromazine ) on the pharmacokinetics of valproic acid in schizophrenic patients . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
15,
27
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
30,
41
]
} |
in a double-blind study of 34 randomly assigned depressed inpatients , antidepressant-induced electroencephalogram ( eeg ) abnormalities were compared in amitriptyline-treated versus bupropion-treated patients . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
71,
85
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
154,
167
]
} |
comparison of the in vitro antifungal activities of clotrimazole , miconazole , econazole and exalamide against clinical isolates of dermatophytes . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
27,
37
]
} | {
"id": "C0025942",
"name": "miconazole",
"pos": [
67,
77
]
} |
comparison of the in vitro antifungal activities of clotrimazole , miconazole , econazole and exalamide against clinical isolates of dermatophytes . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
27,
37
]
} | {
"id": "C0013547",
"name": "econazole",
"pos": [
80,
89
]
} |
the effects of the antirheumatic agents n- ( 2-carboxyphenyl ) -4-chloroanthranilic acid disodium ( cca ) and d-penicillamine on the nk and adcc activities and interferon production of lymphocytes . | therapeutic_class_of | {
"id": "C0003191",
"name": "antirheumatic agents",
"pos": [
19,
39
]
} | {
"id": "C0030817",
"name": "penicillamine",
"pos": [
112,
125
]
} |
although precipitates did occur with a number of neuroleptics , two members of this drug class , thiothixene and molindone , failed to interact with the solutions used . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
49,
61
]
} | {
"id": "C0039955",
"name": "thiothixene",
"pos": [
97,
108
]
} |
although precipitates did occur with a number of neuroleptics , two members of this drug class , thiothixene and molindone , failed to interact with the solutions used . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
49,
61
]
} | {
"id": "C0026388",
"name": "molindone",
"pos": [
113,
122
]
} |
in vitro antibacterial activities ( mic ) of ccl and cex were studied in 74 out of 81 strains ( 41 from aerobes and 40 from anaerobes ) isolated from 47 patients . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
9,
22
]
} | {
"id": "C0007537",
"name": "ccl",
"pos": [
45,
48
]
} |
in vitro antibacterial activities ( mic ) of ccl and cex were studied in 74 out of 81 strains ( 41 from aerobes and 40 from anaerobes ) isolated from 47 patients . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
9,
22
]
} | {
"id": "C0007716",
"name": "cex",
"pos": [
53,
56
]
} |
in vitro and in vivo antibacterial activities of mt-141 , a new cephamycin , against anaerobic bacteria were compared with those of cefmetazole ( cmz ) , cefoxitin , cefotaxime , ceftizoxime , latamoxef and cefazolin to obtain the following results . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
21,
34
]
} | {
"id": "C0007557",
"name": "cefoxitin",
"pos": [
154,
163
]
} |
in vitro and in vivo antibacterial activities of mt-141 , a new cephamycin , against anaerobic bacteria were compared with those of cefmetazole ( cmz ) , cefoxitin , cefotaxime , ceftizoxime , latamoxef and cefazolin to obtain the following results . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
21,
34
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
166,
176
]
} |
in vitro and in vivo antibacterial activities of mt-141 , a new cephamycin , against anaerobic bacteria were compared with those of cefmetazole ( cmz ) , cefoxitin , cefotaxime , ceftizoxime , latamoxef and cefazolin to obtain the following results . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
21,
34
]
} | {
"id": "C0007560",
"name": "ceftizoxime",
"pos": [
179,
190
]
} |
in vitro and in vivo antibacterial activities of mt-141 , a new cephamycin , against anaerobic bacteria were compared with those of cefmetazole ( cmz ) , cefoxitin , cefotaxime , ceftizoxime , latamoxef and cefazolin to obtain the following results . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
21,
34
]
} | {
"id": "C0007546",
"name": "cefazolin",
"pos": [
207,
216
]
} |
antiarrhythmic and cardioprotective effects of propranolol and sotalol were examined by studying their action on cellular electrical activity ( recorded using standard microelectrode techniques ) and creatine-kinase leakage ( measured in the effluent from the experimental bath chamber ) in the in vitro guinea-pig left ventricular myocardium exposed to conditions mimicking severe or moderate ischemia . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
0,
14
]
} | {
"id": "C0037707",
"name": "sotalol",
"pos": [
63,
70
]
} |
the antiepileptic drugs , phenytoin , primidone and phenobarbital , were tested in chinese hamster ovary ( cho ) cells for their ability to induce sister-chromatid exchanges ( sces ) and structural chromosomal aberrations ( cas ) , with and without metabolic activation . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drugs",
"pos": [
4,
23
]
} | {
"id": "C0031507",
"name": "phenytoin",
"pos": [
26,
35
]
} |
the antiepileptic drugs , phenytoin , primidone and phenobarbital , were tested in chinese hamster ovary ( cho ) cells for their ability to induce sister-chromatid exchanges ( sces ) and structural chromosomal aberrations ( cas ) , with and without metabolic activation . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drugs",
"pos": [
4,
23
]
} | {
"id": "C0033148",
"name": "primidone",
"pos": [
38,
47
]
} |
classical neuroleptics like haloperidol , chlorpromazine and metoclopramide inhibited striatal 3h-domp binding in a monophasic manner . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
10,
22
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
28,
39
]
} |
65 depressed women and 33 paranoid-hallucinatory women have been studied while on antidepressant ( clomipramine ) or neuroleptic ( haloperidol ) treatment , respectively . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
82,
96
]
} | {
"id": "C0009010",
"name": "clomipramine",
"pos": [
99,
111
]
} |
65 depressed women and 33 paranoid-hallucinatory women have been studied while on antidepressant ( clomipramine ) or neuroleptic ( haloperidol ) treatment , respectively . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
117,
128
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
131,
142
]
} |
electrophysiological evidence that local anesthetics and antiarrhythmic drugs bind to a specific receptor site in cardiac sodium channels : displacement of bupivacaine by lidocaine . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drugs",
"pos": [
57,
77
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
171,
180
]
} |
antidepressants given once daily for 14 days completely ( desipramine and amitryptiline ) or partially ( mianserin ) reduced the effect of clonidine . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
0,
15
]
} | {
"id": "C0011685",
"name": "desipramine",
"pos": [
58,
69
]
} |
antidepressants given once daily for 14 days completely ( desipramine and amitryptiline ) or partially ( mianserin ) reduced the effect of clonidine . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
0,
15
]
} | {
"id": "C0002600",
"name": "amitryptiline",
"pos": [
74,
87
]
} |
an improved procedure for the sensitive determination of the neuroleptic drug , haloperidol , in human serum is described . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic drug",
"pos": [
61,
77
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
80,
91
]
} |
due to continuous antibacterial prophylaxis ( trimethoprim/sulfamethoxazol ) and treatment of infections with intracellularly accumulating agents ( e.g . rifampicin , fosfomycin , clindamycin ) , even patients with complete defects of bacterial killing can reach adulthood today . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
18,
31
]
} | {
"id": "C0041041",
"name": "trimethoprim",
"pos": [
46,
58
]
} |
due to continuous antibacterial prophylaxis ( trimethoprim/sulfamethoxazol ) and treatment of infections with intracellularly accumulating agents ( e.g . rifampicin , fosfomycin , clindamycin ) , even patients with complete defects of bacterial killing can reach adulthood today . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
18,
31
]
} | {
"id": "C0035608",
"name": "rifampicin",
"pos": [
154,
164
]
} |
due to continuous antibacterial prophylaxis ( trimethoprim/sulfamethoxazol ) and treatment of infections with intracellularly accumulating agents ( e.g . rifampicin , fosfomycin , clindamycin ) , even patients with complete defects of bacterial killing can reach adulthood today . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
18,
31
]
} | {
"id": "C0008947",
"name": "clindamycin",
"pos": [
180,
191
]
} |
bepridil is thus an effective antiarrhythmic agent that affords protection against induction of vt , and this action is similar to the conventional class i antiarrhythmic agent , quinidine , while lacking in another calcium channel blocker , verapamil . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
30,
44
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
179,
188
]
} |
block of sodium currents by antiarrhythmic agents : analysis of the electrophysiologic effects of propafenone in heart muscle . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agents",
"pos": [
28,
49
]
} | {
"id": "C0033429",
"name": "propafenone",
"pos": [
98,
109
]
} |
this method permitted comparisons to be made between propafenone and 3 other antiarrhythmic agents : quinidine , beta-blockers and amiodarone . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agents",
"pos": [
77,
98
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
101,
110
]
} |
this method permitted comparisons to be made between propafenone and 3 other antiarrhythmic agents : quinidine , beta-blockers and amiodarone . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agents",
"pos": [
77,
98
]
} | {
"id": "C0002598",
"name": "amiodarone",
"pos": [
131,
141
]
} |
successful therapy of this infection requires a combination of treatments , including such antifungal drugs as clotrimazole , ketoconazole , or amphotericin b and correction of the underlying immune defect with such agents as transfer factor . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal drugs",
"pos": [
91,
107
]
} | {
"id": "C0022625",
"name": "ketoconazole",
"pos": [
126,
138
]
} |
successful therapy of this infection requires a combination of treatments , including such antifungal drugs as clotrimazole , ketoconazole , or amphotericin b and correction of the underlying immune defect with such agents as transfer factor . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal drugs",
"pos": [
91,
107
]
} | {
"id": "C0002679",
"name": "amphotericin b",
"pos": [
144,
158
]
} |
improved methods of candida detection and less toxic antifungals are urgently needed , but in the interim , treatment regimens should require a greater index of suspicion before initiating amphotericin therapy in patients receiving cyclosporine . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungals",
"pos": [
53,
64
]
} | {
"id": "C0002679",
"name": "amphotericin",
"pos": [
189,
201
]
} |
a random sample of 52 borderline and schizotypal patients was treated with two major neuroleptics , thiothixene and haloperidol , in a double-blind study . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
85,
97
]
} | {
"id": "C0039955",
"name": "thiothixene",
"pos": [
100,
111
]
} |
a random sample of 52 borderline and schizotypal patients was treated with two major neuroleptics , thiothixene and haloperidol , in a double-blind study . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
85,
97
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
116,
127
]
} |
the new anti-arrhythmic agent flecainide was compared in a single-blind cross-over study to arabogalactane quinidine sulfate in the treatment of stable chronic extrasystole , using a fixed twice-daily dose protocol . | therapeutic_class_of | {
"id": "C0003195",
"name": "anti-arrhythmic agent",
"pos": [
8,
29
]
} | {
"id": "C0016229",
"name": "flecainide",
"pos": [
30,
40
]
} |
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