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other antiarrhythmic agents , procainamide and lidocaine , also increased sarcolemmal ca2+-atpase activity without affecting the na+-k+ atpase . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agents",
"pos": [
6,
27
]
} | {
"id": "C0033216",
"name": "procainamide",
"pos": [
30,
42
]
} |
other antiarrhythmic agents , procainamide and lidocaine , also increased sarcolemmal ca2+-atpase activity without affecting the na+-k+ atpase . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agents",
"pos": [
6,
27
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
47,
56
]
} |
the antimalarial monovalent drugs quinine and mefloquine , but not chloroquine , also penetrate into the membrane and expand it . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial",
"pos": [
4,
16
]
} | {
"id": "C0025153",
"name": "mefloquine",
"pos": [
46,
56
]
} |
the antimalarial monovalent drugs quinine and mefloquine , but not chloroquine , also penetrate into the membrane and expand it . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial",
"pos": [
4,
16
]
} | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
67,
78
]
} |
the non-gabaergic hypotheses have been also considered to explain the anti-epileptic action of vpa , one hypothesis depends on the effects of vpa directly on the membrane , another hypothesis brings into play aspartate , and finally a hypothesis depending on the inhibition of aldehyde reductases . | therapeutic_class_of | {
"id": "C0003299",
"name": "anti-epileptic",
"pos": [
70,
84
]
} | {
"id": "C0042291",
"name": "vpa",
"pos": [
142,
145
]
} |
among the newer antiarrhythmic drugs currently being evaluated are the four so-called lidocaine congeners , encainide , flecainide , lorcainide and tocainide . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drugs",
"pos": [
16,
36
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
86,
95
]
} |
among the newer antiarrhythmic drugs currently being evaluated are the four so-called lidocaine congeners , encainide , flecainide , lorcainide and tocainide . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drugs",
"pos": [
16,
36
]
} | {
"id": "C0016229",
"name": "flecainide",
"pos": [
120,
130
]
} |
antidepressants belonging to the lu series affected mainly serotonin , whereas desipramine and nortriptyline mainly the noradrenaline uptake and release . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
0,
15
]
} | {
"id": "C0011685",
"name": "desipramine",
"pos": [
79,
90
]
} |
antidepressants belonging to the lu series affected mainly serotonin , whereas desipramine and nortriptyline mainly the noradrenaline uptake and release . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
0,
15
]
} | {
"id": "C0028420",
"name": "nortriptyline",
"pos": [
95,
108
]
} |
as regards the power of the antiarrhythmic effect , the compounds under study -- hydrochlorides of arylamides of n-hydroxyalkly-alpha-piperidine carboxylic acids -- approach lidocaine , yield to marcaine , and exhibit a broader range of therapeutic action . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
28,
42
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
174,
183
]
} |
mexiletine , an antiarrhythmic drug with pharmacological properties similar to lidocaine , was tested for antipruritic effect in 4 patients with severe pruritus . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drug",
"pos": [
16,
35
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
79,
88
]
} |
the possibility of interactions with such commonly used antiarrhythmic drugs as quinidine and amiodarone must be considered . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drugs",
"pos": [
56,
76
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
80,
89
]
} |
the possibility of interactions with such commonly used antiarrhythmic drugs as quinidine and amiodarone must be considered . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drugs",
"pos": [
56,
76
]
} | {
"id": "C0002598",
"name": "amiodarone",
"pos": [
94,
104
]
} |
a case history is reported of a patient who had several episodes of unconsciousness ( because of ventricular extrasystole ) while on antiarrhythmic and antihypertensive therapy consisting of quinidine ( 200 mg b. i. d. ) , sotalol ( 80 mg b. i. d. ) and hydrochlorothiazide ( 50 mg g. d. ) . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
133,
147
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
191,
200
]
} |
a case history is reported of a patient who had several episodes of unconsciousness ( because of ventricular extrasystole ) while on antiarrhythmic and antihypertensive therapy consisting of quinidine ( 200 mg b. i. d. ) , sotalol ( 80 mg b. i. d. ) and hydrochlorothiazide ( 50 mg g. d. ) . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
133,
147
]
} | {
"id": "C0037707",
"name": "sotalol",
"pos": [
223,
230
]
} |
only 1 patient neither smoked nor wore dentures and she was taking an antidepressant ( imipramine hydrochloride ) with a reported association with oral candidosis . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
70,
84
]
} | {
"id": "C0589978",
"name": "imipramine hydrochloride",
"pos": [
87,
111
]
} |
two topical antifungals , butoconazole and terconazole , and two systemic antifungals , itraconazole and vibunazole , gave mean rifs less than 60 % in tests with candida species , and therefore matched clotrimazole , ketoconazole and tioconazole in terms of rif . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungals",
"pos": [
12,
23
]
} | {
"id": "C0022625",
"name": "ketoconazole",
"pos": [
217,
229
]
} |
its antibacterial activity is less than that of the parent molecule , but the combination of cefotaxime and desacetyl-cefotaxime is often synergistic . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
118,
128
]
} |
a highly sensitive , rapid , and specific high pressure liquid chromatographic assay for the analysis of the antiarrhythmic agent mexiletine is reported . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agent",
"pos": [
109,
129
]
} | {
"id": "C0025887",
"name": "mexiletine",
"pos": [
130,
140
]
} |
the antiarrhythmic effects of the sustained release form of mexiletine ( mexitil-perlongets ) were evaluated in a double-blind placebo trial in 630 patients with recent documented myocardial infarction . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
4,
18
]
} | {
"id": "C0025887",
"name": "mexiletine",
"pos": [
60,
70
]
} |
several other antiarrhythmic agents and one beta-blocker , which might be administered concurrently with flecainide acetate , do not interfere with the assay . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agents",
"pos": [
14,
35
]
} | {
"id": "C0086303",
"name": "flecainide acetate",
"pos": [
105,
123
]
} |
the antidiarrheal opiates loperamide , fluperamide , diphenoxylate and fetoxylate inhibited binding of [ 3h ] nitrendipine to membranes from guinea-pig cerebral cortex with ki values of 0.5 to 10 microm . | therapeutic_class_of | {
"id": "C0003292",
"name": "antidiarrheal",
"pos": [
4,
17
]
} | {
"id": "C0012525",
"name": "diphenoxylate",
"pos": [
53,
66
]
} |
this was preceded by a rapid uniform ventricular tachycardia in one patient with normal q-t interval and by polymorphous ventricular tachycardia in the other whose q-t was prolonged on combined antiarrhythmic therapy with propafenone and mexiletine . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
194,
208
]
} | {
"id": "C0033429",
"name": "propafenone",
"pos": [
222,
233
]
} |
this was preceded by a rapid uniform ventricular tachycardia in one patient with normal q-t interval and by polymorphous ventricular tachycardia in the other whose q-t was prolonged on combined antiarrhythmic therapy with propafenone and mexiletine . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
194,
208
]
} | {
"id": "C0025887",
"name": "mexiletine",
"pos": [
238,
248
]
} |
temporal changes in the avoidance responses and serum prolactin levels were investigated for a 360 min period after s.c. administration of antipsychotic drugs such as chlorpromazine ( 2 mg/kg ) , prochlorperazine ( 2 mg/kg ) , haloperidol ( 0.035 mg/kg ) , droperidol ( 0.03 mg/kg ) , ym-09151-2 ( 0.005 mg/kg ) and sulpiride ( 80 mg/kg ) in rats . | therapeutic_class_of | {
"id": "C0040615",
"name": "antipsychotic",
"pos": [
139,
152
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
227,
238
]
} |
a prospective trial in 80 patients randomly allocated to four antimalarial treatment regimens -- mefloquine plus pyrimethamine-sulfadoxine ( 'fansidar ' ) ; | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial",
"pos": [
62,
74
]
} | {
"id": "C0025153",
"name": "mefloquine",
"pos": [
97,
107
]
} |
the effects of two antipsychotic drugs , haloperidol and clozapine , on the detection of electrical brain stimulation were investigated . | therapeutic_class_of | {
"id": "C0040615",
"name": "antipsychotic",
"pos": [
19,
32
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
41,
52
]
} |
the effect of a new neuroleptic agent , zetidoline , 1- ( 3-chlorophenyl ) -3- [ 2- ( 3,3-dimethyl-l-azetidinyl ) ethyl ] imidaz olidin-2-one ( zet ) , on prolactin release was studied in both male and female rats and compared to that of the classic antipsychotic drugs chlorpromazine and haloperidol . | therapeutic_class_of | {
"id": "C0040615",
"name": "antipsychotic drugs",
"pos": [
250,
269
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
289,
300
]
} |
the antidepressant compounds clomipramine and nitroimipramine were cidal to extracellular promastigotes of both human protozoan parasites leishmania donovani and leishmania major . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
4,
18
]
} | {
"id": "C0009010",
"name": "clomipramine",
"pos": [
29,
41
]
} |
with continued use of this convenient antiarrhythmic agent , it is important that physicians be alert to the possibility of agranulocytosis in febrile patients receiving procainamide . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agent",
"pos": [
38,
58
]
} | {
"id": "C0033216",
"name": "procainamide",
"pos": [
170,
182
]
} |
low-frequency stimulation of the caudate nucleus and administration of neuroleptics ( haloperidol and clozapine ) facilitate destabilization of the fluctuations curve and synchronize changes in the frequency of the left and the right head turnings . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
71,
83
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
86,
97
]
} |
a new antiarrhythmic drug , droxicainide , was compared with lidocaine in order to evaluate droxicainide 's effect on heart muscle . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drug",
"pos": [
6,
25
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
61,
70
]
} |
serum levels of four antiarrhythmic agents ( long-acting procainamide , quinidine sulfate , quinidine gluconate , and disopyramide ) were determined in 98 consecutive ambulatory patients receiving long-term oral therapy . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agents",
"pos": [
21,
42
]
} | {
"id": "C0033216",
"name": "procainamide",
"pos": [
57,
69
]
} |
serum levels of four antiarrhythmic agents ( long-acting procainamide , quinidine sulfate , quinidine gluconate , and disopyramide ) were determined in 98 consecutive ambulatory patients receiving long-term oral therapy . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agents",
"pos": [
21,
42
]
} | {
"id": "C0034415",
"name": "quinidine sulfate",
"pos": [
72,
89
]
} |
serum levels of four antiarrhythmic agents ( long-acting procainamide , quinidine sulfate , quinidine gluconate , and disopyramide ) were determined in 98 consecutive ambulatory patients receiving long-term oral therapy . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agents",
"pos": [
21,
42
]
} | {
"id": "C0072869",
"name": "quinidine gluconate",
"pos": [
92,
111
]
} |
serum levels of four antiarrhythmic agents ( long-acting procainamide , quinidine sulfate , quinidine gluconate , and disopyramide ) were determined in 98 consecutive ambulatory patients receiving long-term oral therapy . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agents",
"pos": [
21,
42
]
} | {
"id": "C0012702",
"name": "disopyramide",
"pos": [
118,
130
]
} |
the 12 antimicrobial agents tested were ampicillin , amoxicillin , clindamycin , chloramphenicol , erythromycin , furazolidone , norfloxacin , nalidixic acid , rosoxacin , rosaramicin , tetracycline , and sch 32063 . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial",
"pos": [
7,
20
]
} | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
99,
111
]
} |
the 12 antimicrobial agents tested were ampicillin , amoxicillin , clindamycin , chloramphenicol , erythromycin , furazolidone , norfloxacin , nalidixic acid , rosoxacin , rosaramicin , tetracycline , and sch 32063 . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial",
"pos": [
7,
20
]
} | {
"id": "C0028365",
"name": "norfloxacin",
"pos": [
129,
140
]
} |
the 12 antimicrobial agents tested were ampicillin , amoxicillin , clindamycin , chloramphenicol , erythromycin , furazolidone , norfloxacin , nalidixic acid , rosoxacin , rosaramicin , tetracycline , and sch 32063 . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial",
"pos": [
7,
20
]
} | {
"id": "C0039644",
"name": "tetracycline",
"pos": [
186,
198
]
} |
the efficacy was scored from 1 ( no effect ) to 5 ( complete control ) as judged by the clinical response , the results of holter monitoring ( 175 control and 133 test recordings on therapy ) , and a comparison was made between the effects of propafenone and other antiarrhythmics : quinidine-like drugs , beta-blockers and amiodarone . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmics",
"pos": [
265,
280
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
283,
292
]
} |
the efficacy was scored from 1 ( no effect ) to 5 ( complete control ) as judged by the clinical response , the results of holter monitoring ( 175 control and 133 test recordings on therapy ) , and a comparison was made between the effects of propafenone and other antiarrhythmics : quinidine-like drugs , beta-blockers and amiodarone . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmics",
"pos": [
265,
280
]
} | {
"id": "C0002598",
"name": "amiodarone",
"pos": [
324,
334
]
} |
the antiarrhythmic effect of propafenone was appreciable in 10 cases of resistant post-infarction ventricular tachycardia , eventually in association with amiodarone . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
4,
18
]
} | {
"id": "C0033429",
"name": "propafenone",
"pos": [
29,
40
]
} |
the antiarrhythmic effect of propafenone was appreciable in 10 cases of resistant post-infarction ventricular tachycardia , eventually in association with amiodarone . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
4,
18
]
} | {
"id": "C0002598",
"name": "amiodarone",
"pos": [
155,
165
]
} |
pharmacokinetics of oral contraceptive steroids following the administration of the antimalarial drugs primaquine and chloroquine . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial",
"pos": [
84,
96
]
} | {
"id": "C0033126",
"name": "primaquine",
"pos": [
103,
113
]
} |
pharmacokinetics of oral contraceptive steroids following the administration of the antimalarial drugs primaquine and chloroquine . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial",
"pos": [
84,
96
]
} | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
118,
129
]
} |
the effects of a single dose of two antimalarial drugs chloroquine ( cq ) and primaquine ( pq ) on the pharmacokinetics of a combined oral contraceptive ( o.c . ) have been studied in volunteers . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial",
"pos": [
36,
48
]
} | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
55,
66
]
} |
the effects of a single dose of two antimalarial drugs chloroquine ( cq ) and primaquine ( pq ) on the pharmacokinetics of a combined oral contraceptive ( o.c . ) have been studied in volunteers . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial",
"pos": [
36,
48
]
} | {
"id": "C0033126",
"name": "primaquine",
"pos": [
78,
88
]
} |
( 30 micrograms ee2 + 150 micrograms levonorgestrel ) in the absence and presence of the antimalarial drugs ( pq , 45 mg ; cq , 300 mg ) . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial",
"pos": [
89,
101
]
} | {
"id": "C0033126",
"name": "pq",
"pos": [
110,
112
]
} |
( 30 micrograms ee2 + 150 micrograms levonorgestrel ) in the absence and presence of the antimalarial drugs ( pq , 45 mg ; cq , 300 mg ) . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial",
"pos": [
89,
101
]
} | {
"id": "C0008269",
"name": "cq",
"pos": [
123,
125
]
} |
identification of the acidic compartment of plasmodium falciparum-infected human erythrocytes as the target of the antimalarial drug chloroquine . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial drug",
"pos": [
115,
132
]
} | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
133,
144
]
} |
the antimalarial drugs chloroquine and pyrimethamine were observed to afford protection to mice treated with these agents . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial drugs",
"pos": [
4,
22
]
} | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
23,
34
]
} |
[ antiarrhythmic activity of beta-aminoketones in comparison with quinidine and procaine amide in arrhythmia produced by calcium chloride in mice ] . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
2,
16
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
66,
75
]
} |
[ antiarrhythmic activity of beta-aminoketones in comparison with quinidine and procaine amide in arrhythmia produced by calcium chloride in mice ] . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
2,
16
]
} | {
"id": "C0033216",
"name": "procaine amide",
"pos": [
80,
94
]
} |
this formulation , though less active and more variable as a detergent skin antiseptic than chlorhexidine , hexachlorophane , or povidone iodine detergent preparations , is an inexpensive disinfectant soap which could be useful in catering establishments . | therapeutic_class_of | {
"id": "C0003205",
"name": "antiseptic",
"pos": [
76,
86
]
} | {
"id": "C0019435",
"name": "hexachlorophane",
"pos": [
108,
123
]
} |
this formulation , though less active and more variable as a detergent skin antiseptic than chlorhexidine , hexachlorophane , or povidone iodine detergent preparations , is an inexpensive disinfectant soap which could be useful in catering establishments . | therapeutic_class_of | {
"id": "C0003205",
"name": "antiseptic",
"pos": [
76,
86
]
} | {
"id": "C0032857",
"name": "povidone iodine",
"pos": [
129,
144
]
} |
the in vitro demonstration of the efficacy of trimethoprim as an antibacterial agent in a comparative bacteriological study of the effects of trimethoprim , sulfamethoxazole and the combination trimethoprim-sulfamethoxazole . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
65,
78
]
} | {
"id": "C0041041",
"name": "trimethoprim",
"pos": [
194,
206
]
} |
regarding interrelationships between epilepsy , antiepileptic drugs and neuroendocrinological events , sodium valproate effects on estrous cycle of the rat have been performed by daily vaginal smears for twenty one days with 200 , 100 , 20 and 10 mg per kg bodyweight . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drugs",
"pos": [
48,
67
]
} | {
"id": "C0037567",
"name": "sodium valproate",
"pos": [
103,
119
]
} |
the abbott-vp bichromatic analyzer was used for the determination of four antiepileptic drugs ( phenobarbital , phenytoin , carbamazepine , primidone ) in serum by means of a modified emit homogeneous enzyme immunoassay procedure . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drugs",
"pos": [
74,
93
]
} | {
"id": "C0031507",
"name": "phenytoin",
"pos": [
112,
121
]
} |
the abbott-vp bichromatic analyzer was used for the determination of four antiepileptic drugs ( phenobarbital , phenytoin , carbamazepine , primidone ) in serum by means of a modified emit homogeneous enzyme immunoassay procedure . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drugs",
"pos": [
74,
93
]
} | {
"id": "C0033148",
"name": "primidone",
"pos": [
140,
149
]
} |
in particular , the n-butylurea ( iv b ) was superior to lidocaine concerning the anesthetic effect , and the benzamide ( v f ) showed the same degree of local anesthetic and antiarrhythmic activity as lidocaine . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
175,
189
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
202,
211
]
} |
digital computer period analysis of the eeg confirmed nomifensine as a drug with a significant effect on the cns as compared with placebo , showing in fact an antidepressant 'pharmaco-eeg profile ' similar to desipramine . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
159,
173
]
} | {
"id": "C0011685",
"name": "desipramine",
"pos": [
209,
220
]
} |
we have studied the antimicrobial action of metronidazole against bacteroides fragilis and escherichia coli both in pure cultures and in combination . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial",
"pos": [
20,
33
]
} | {
"id": "C0025872",
"name": "metronidazole",
"pos": [
44,
57
]
} |
methicillin was the most effective antimicrobial agent against pathologic staphylococci ( 2.2 % resistance ) , followed by erythromycin ( 16.5 % resistance ) , co-trimaxozole ( 28.0 % resistance ) , chloramphenicol ( 76.9 % resistance ) , tetracycline ( 78.6 % resistance ) and penicillin and ampicillin ( 97.8 % resistance ) . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial agent",
"pos": [
35,
54
]
} | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
123,
135
]
} |
methicillin was the most effective antimicrobial agent against pathologic staphylococci ( 2.2 % resistance ) , followed by erythromycin ( 16.5 % resistance ) , co-trimaxozole ( 28.0 % resistance ) , chloramphenicol ( 76.9 % resistance ) , tetracycline ( 78.6 % resistance ) and penicillin and ampicillin ( 97.8 % resistance ) . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial agent",
"pos": [
35,
54
]
} | {
"id": "C0039644",
"name": "tetracycline",
"pos": [
239,
251
]
} |
antibacterial drugs ( oxytetracycline , streptomycin and sulphonamides ) were included in the drinking water of healthy broiler chicks from the sixth to the twentieth day of life to select a resistant gut flora . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial drugs",
"pos": [
0,
19
]
} | {
"id": "C0038425",
"name": "streptomycin",
"pos": [
40,
52
]
} |
bacteriological findings revealed that cfx was highly effective against e. coli , klebsiella , p. morganii and neisseria , and antibacterial activity of cfx was equal or slightly superior than those of abpc and cez , however , cfx was less effective against enterobacter and s. faecalis . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
127,
140
]
} | {
"id": "C0007557",
"name": "cfx",
"pos": [
227,
230
]
} |
( 2 ) in terms of distribution of sensitivity of clinically isolated bacterial strains , ntl proved to have antibacterial potency comparable to that of gm and higher potency than that of dkb of amk against e. coli k. pneumonia , enterobacter sp. , or h. influenzae . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
108,
121
]
} | {
"id": "C0002499",
"name": "amk",
"pos": [
194,
197
]
} |
( 3 ) in conjunction with the influences of ph of culture media or of addition of horse sera upon the antibacterial efficacy , ntl showed an inclination similar to that of gm , dkb and akm . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
102,
115
]
} | {
"id": "C0027780",
"name": "ntl",
"pos": [
127,
130
]
} |
[ electron microscopic and electrophysiological study of the effect of the antimalarials dabequine and chloroquine on the retina of white rats ] . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarials",
"pos": [
75,
88
]
} | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
103,
114
]
} |
the antiarrhythmic effect of intravenous disopyramide phosphate was assessed in a multicentre open study of 141 patients admitted to coronary care units . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
4,
18
]
} | {
"id": "C0700534",
"name": "disopyramide phosphate",
"pos": [
41,
63
]
} |
following results were obtained : 1 ) treatment with antipsychotics involving pimozide ( 0.4 mg/kg ) , haloperidol ( 0.4 mg/kg ) and spiperone ( 0.5 mg/kg ) facilitated the development of amygdaloid kindling . | therapeutic_class_of | {
"id": "C0040615",
"name": "antipsychotics",
"pos": [
53,
67
]
} | {
"id": "C0031935",
"name": "pimozide",
"pos": [
78,
86
]
} |
following results were obtained : 1 ) treatment with antipsychotics involving pimozide ( 0.4 mg/kg ) , haloperidol ( 0.4 mg/kg ) and spiperone ( 0.5 mg/kg ) facilitated the development of amygdaloid kindling . | therapeutic_class_of | {
"id": "C0040615",
"name": "antipsychotics",
"pos": [
53,
67
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
103,
114
]
} |
the effects of three cationic amphiphilic antimalarial drugs ( chloroquine , mepacrine and primaquine ) on the intralysosomal catabolism of phosphatidylethanolamine and several of its metabolites were studied with rat-liver lysosomes which had been isolated from animals previously treated with triton wr-1339 . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial",
"pos": [
42,
54
]
} | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
63,
74
]
} |
the effects of three cationic amphiphilic antimalarial drugs ( chloroquine , mepacrine and primaquine ) on the intralysosomal catabolism of phosphatidylethanolamine and several of its metabolites were studied with rat-liver lysosomes which had been isolated from animals previously treated with triton wr-1339 . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial",
"pos": [
42,
54
]
} | {
"id": "C0033126",
"name": "primaquine",
"pos": [
91,
101
]
} |
in experiments with left atrial and right ventricular tissues fast sodium current ( ina ) was decreased by substituting sucrose for sodium in tyrode 's solution and with antiarrhythmic drugs -- ina blockers ( lidocaine , diphenylhydantoine and ethmozine ) . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drugs",
"pos": [
170,
190
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
209,
218
]
} |
we investigated the antibacterial activity of ceftriaxone at concentrations of 1/4 x minimum inhibition concentration ( mic ) , 1 x mic and 4 x mic against a serum-resistant pseudomonas aeruginosa and a serum-resistant staphylococcus aureus strain in broth , serum , and in combination with leukocytes . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
20,
33
]
} | {
"id": "C0007561",
"name": "ceftriaxone",
"pos": [
46,
57
]
} |
the antibacterial activity of ceftriaxone was most effective in combination with leukocytes and serum , achieving a marked bactericidal effect already at subinhibitory ceftriaxone concentrations . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0007561",
"name": "ceftriaxone",
"pos": [
168,
179
]
} |
antagonism followed by recovery.4 when different doses of the same antidepressant were applied , it was found that the drug-interaction patterns were related to the dose of antidepressant applied , a lower dose causing potentiation , and a higher dose antagonism of the response.5 both potentiation and antagonism of depressant responses to noradrenaline could be observed.6 both excitatory and depressant responses to 5-hydroxytryptamine were modified by imipramine and desipramine : a smaller dose of the antidepressant potentiated , and a higher dose antagonized the responses.7 excitatory responses to glutamate were not affected by imipramine and desipramine . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
67,
81
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
637,
647
]
} |
antagonism followed by recovery.4 when different doses of the same antidepressant were applied , it was found that the drug-interaction patterns were related to the dose of antidepressant applied , a lower dose causing potentiation , and a higher dose antagonism of the response.5 both potentiation and antagonism of depressant responses to noradrenaline could be observed.6 both excitatory and depressant responses to 5-hydroxytryptamine were modified by imipramine and desipramine : a smaller dose of the antidepressant potentiated , and a higher dose antagonized the responses.7 excitatory responses to glutamate were not affected by imipramine and desipramine . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
67,
81
]
} | {
"id": "C0011685",
"name": "desipramine",
"pos": [
652,
663
]
} |
antirheumatic drugs reviewed are salicylates ( including aspirin , sodium salicylate , choline salicylate , choline magnesium salicylate , salsalate ) , phenylpropionic acid derivatives ( fenoprofen , ibuprofen , naproxen ) , indole derivatives ( sulindac , tolmetin and indomethacin ) , pyrazolone derivatives ( phenylbutazone , oxyphenbutazone ) , gold compounds , penicillamine , antimalarials mefenamic acid , corticosteroids and immunosuppressives . | therapeutic_class_of | {
"id": "C0003191",
"name": "antirheumatic drugs",
"pos": [
0,
19
]
} | {
"id": "C0030817",
"name": "penicillamine",
"pos": [
367,
380
]
} |
three patients treated with amphotericin b , single course as well as multiple courses , and other antifungal agents ( hydroxystilbamidine and miconazole ) have all relapsed . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal agents",
"pos": [
99,
116
]
} | {
"id": "C0025942",
"name": "miconazole",
"pos": [
143,
153
]
} |
[ effects of antidepressants ( amoxapine and imipramine ) on serum anterior pituitary hormone levels in patients with depressive states ( author 's transl ) ] . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
13,
28
]
} | {
"id": "C0002644",
"name": "amoxapine",
"pos": [
31,
40
]
} |
[ effects of antidepressants ( amoxapine and imipramine ) on serum anterior pituitary hormone levels in patients with depressive states ( author 's transl ) ] . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
13,
28
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
45,
55
]
} |
a tentative dosage adjustment schedule for individualising antidepressant treatment with nortriptyline based on the 48 hour or the 24 hour plasma concentration is proposed . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
59,
73
]
} | {
"id": "C0028420",
"name": "nortriptyline",
"pos": [
89,
102
]
} |
the antibacterial activities of three aminopenicillins ampicillin , epicillin and amoxycillin were compared in vitro and in vivo . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
55,
65
]
} |
the antibacterial activities of three aminopenicillins ampicillin , epicillin and amoxycillin were compared in vitro and in vivo . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0002645",
"name": "amoxycillin",
"pos": [
82,
93
]
} |
ten patients with persistent ventricular arrhythmia were studied in a comparison of the antiarrhythmic efficacy of n-acetylprocainamide ( napa ) and procainamide ( pa ) . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
88,
102
]
} | {
"id": "C0033216",
"name": "procainamide",
"pos": [
149,
161
]
} |
the neuroleptic agent haloperidol blocked the hypothermia produced by these apomorphines but alpha-methyl-p-tyrosine failed to do so . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic agent",
"pos": [
4,
21
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
22,
33
]
} |
plastic ion-selective electrode analysis of the hydrophobic amine antimalarial mefloquine in blood samples was investigated . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial",
"pos": [
66,
78
]
} | {
"id": "C0025153",
"name": "mefloquine",
"pos": [
79,
89
]
} |
to clarify the electrophysiological mechanisms of the antiarrhythmic effects of mexiletine , we examined the actions of mexiletine ( 0.1 -- 30 mg/l ) on action potential characteristics ( phase 0 amplitude , overshoot , maximum upstroke velocity , maximum diastolic and activation voltages , duration at 50 % and 90 % repolarization ) of cardiac purkinje fibers using standard microelectrode techniques . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
54,
68
]
} | {
"id": "C0025887",
"name": "mexiletine",
"pos": [
120,
130
]
} |
this broad antibacterial spectrum suggested that cefoxitin might be an effective single antibiotic agent for the treatment of mixed aerobic-anaerobic infections in obstetric and gynecologic patients . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
11,
24
]
} | {
"id": "C0007557",
"name": "cefoxitin",
"pos": [
49,
58
]
} |
apomorphine ( 0.12 -- 2 mg/kg , sc ) and d-amphetamine ( 1 -- 8 mg/kg , ip ) were each able , at certain doses , to potentiate the cataleptic state produced by the neuroleptic agent , haloperidol ( 1 mg/kg , ip ) . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic agent",
"pos": [
164,
181
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
184,
195
]
} |
[ antibacterial action in vitro of the association of trimethoprim and sulfamethoxazole on salmonella typhi and paratyphi ] . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
2,
15
]
} | {
"id": "C0041041",
"name": "trimethoprim",
"pos": [
54,
66
]
} |
the use of antiseptics ( hexachlorophene and chlorhexidine ) and gentamicin nose cream in children and staff members in three out of five clinical units resulted in a significant reduction of the prevalence of nose colonization by mers in children . | therapeutic_class_of | {
"id": "C0003205",
"name": "antiseptics",
"pos": [
11,
22
]
} | {
"id": "C0019435",
"name": "hexachlorophene",
"pos": [
25,
40
]
} |
relations among antimalarial drugs : results of studies with cycloguanil- , sulfone- , or chloroquine-resistant plasmodium berghei in mice . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial drugs",
"pos": [
16,
34
]
} | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
90,
101
]
} |
a comparison of the antiarrhythmic actions of two new synthetic compounds , iproveratril and mj 1999 , with quinidine and pronethalol . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
20,
34
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
108,
117
]
} |
the antifungal activities of nystatin and amphotericin b were the least subject to vitiation by the addition of steroids other than ergosterol , and those of filipin , rimocidin , and pimaricin were the most sensitive to interference . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
4,
14
]
} | {
"id": "C0002679",
"name": "amphotericin b",
"pos": [
42,
56
]
} |
increased concentrations of the antifungal agents amphotericin b or endomycin , while reducing the number of respiration-deficient mutants , did not significantly increase the final mutant-wild type ratio . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal agents",
"pos": [
32,
49
]
} | {
"id": "C0002679",
"name": "amphotericin b",
"pos": [
50,
64
]
} |
the effect of the zinc sulphate and of the adrenaline upon the antibacterial power of the chloramphenicol . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
63,
76
]
} | {
"id": "C0008168",
"name": "chloramphenicol",
"pos": [
90,
105
]
} |
[ histological researches on the rat encephalon after prolonged administration of antidepressive drugs . ( comparative histopathological pictures after imipramine and phenelzine administration ) ] . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressive",
"pos": [
82,
96
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
152,
162
]
} |
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