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the antibacterial activity of ctm against s. aureus was equal or slightly less than that of cefazolin ( cez ) . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0007546",
"name": "cefazolin",
"pos": [
92,
101
]
} |
since acute pretreatment with comparable clinical doses of the antidepressive drugs , mianserin , amitriptyline , imipramine , or iprindole , resulted in blockade of the 5-htp induced depression by 70 , 50 , 40 , and 20 % respectively , these drugs can act as antagonists of 5-ht at the postsynaptic serotonin receptor . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressive",
"pos": [
63,
77
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
98,
111
]
} |
since acute pretreatment with comparable clinical doses of the antidepressive drugs , mianserin , amitriptyline , imipramine , or iprindole , resulted in blockade of the 5-htp induced depression by 70 , 50 , 40 , and 20 % respectively , these drugs can act as antagonists of 5-ht at the postsynaptic serotonin receptor . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressive",
"pos": [
63,
77
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
114,
124
]
} |
the effects of the neuroleptic pimozide , a specific dopamine receptor blocker , on behavior maintained under different degrees of stimulus control was examined by using a fixed consecutive number ( fcn ) schedule of reinforcement with pigeons . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
19,
30
]
} | {
"id": "C0031935",
"name": "pimozide",
"pos": [
31,
39
]
} |
trazodone ( tz ) , a 'new generation ' antidepressant and amitriptyline ( amt ) were administered in a double-blind controlled study to 43 depressed inpatients . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
39,
53
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
58,
71
]
} |
120 strains of candida spp were tested against the antifungal agents 5-fluorocytosine , amphotericine b and the imidazoles econazole , miconazole and clotrimazole . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal agents",
"pos": [
51,
68
]
} | {
"id": "C0013547",
"name": "econazole",
"pos": [
123,
132
]
} |
120 strains of candida spp were tested against the antifungal agents 5-fluorocytosine , amphotericine b and the imidazoles econazole , miconazole and clotrimazole . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal agents",
"pos": [
51,
68
]
} | {
"id": "C0025942",
"name": "miconazole",
"pos": [
135,
145
]
} |
a sub-group of 128 was chosen for a six-month study on the effect of treatment with the anthelmintic mebendazole and/or parenteral iron on haemoglobin and serum ferritin levels . | therapeutic_class_of | {
"id": "C0003158",
"name": "anthelmintic",
"pos": [
88,
100
]
} | {
"id": "C0025023",
"name": "mebendazole",
"pos": [
101,
112
]
} |
the antibacterial activity of tobramycin , gentamicin , amikacin , sisomicin and kanamycin against 192 strains of genus proteus has been studied in vitro . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0040341",
"name": "tobramycin",
"pos": [
30,
40
]
} |
the antibacterial activity of tobramycin , gentamicin , amikacin , sisomicin and kanamycin against 192 strains of genus proteus has been studied in vitro . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0002499",
"name": "amikacin",
"pos": [
56,
64
]
} |
the antibacterial activity of tobramycin , gentamicin , amikacin , sisomicin and kanamycin against 192 strains of genus proteus has been studied in vitro . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0022487",
"name": "kanamycin",
"pos": [
81,
90
]
} |
( 6r , 7r ) -7- [ [ carboxy ( 4-hydroxyphenyl ) -acetyl ] amino ] -7-methoxy-3 [ [ ( 1-methyl-1h-tetrazo l-5-yl ) thio ] methyl ] -8-oxo-5-oxa-1-azabicyclo [ 4,2,0 ] oct-2-ene-2-carboxylic acid ( moxalactam , ly 127 935 ) , a novel 1-oxa-beta-lactam , was proved to display similar antibacterial activity as cefotaxime against a number of beta-lactamase-producing gram-negative strains . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
282,
295
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
308,
318
]
} |
because an antibacterial effect of aha , and synergy between kanamycin and aha have also been described , we studied the interaction between aha and 12 antibiotics against 14 gram-negative bacteria . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
11,
24
]
} | {
"id": "C0022487",
"name": "kanamycin",
"pos": [
61,
70
]
} |
resistance of the salmonella strains to one or more of the 12 antimicrobials tested and the frequency of resistance to tetracycline and ampicillin were significantly greater than resistance reported in other studies performed in this country . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobials",
"pos": [
62,
76
]
} | {
"id": "C0039644",
"name": "tetracycline",
"pos": [
119,
131
]
} |
proceedings : the potentiation of the antiarrhythmic effects of quinidine sulfate , lidocaine and ajmaline by tween 80 . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
38,
52
]
} | {
"id": "C0034415",
"name": "quinidine",
"pos": [
64,
73
]
} |
proceedings : the potentiation of the antiarrhythmic effects of quinidine sulfate , lidocaine and ajmaline by tween 80 . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
38,
52
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
84,
93
]
} |
a comparison of the antidepressant effects of a synthetic androgen ( mesterolone ) and amitriptyline in depressed men . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
20,
34
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
87,
100
]
} |
the antidepressant effects of amitriptyline and mesterolone , a synthetic androgen , were compared in a double-blind parallel treatment design . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
4,
18
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
30,
43
]
} |
to counter this problem several new antibacterial agents were tested in combination with silver sulfadiazine . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
36,
49
]
} | {
"id": "C0037134",
"name": "silver sulfadiazine",
"pos": [
89,
108
]
} |
these patients illustrate the need for careful supervision of antiarrhythmic therapy for vt , even when lignocaine-like drugs are being used . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
62,
76
]
} | {
"id": "C0023660",
"name": "lignocaine",
"pos": [
104,
114
]
} |
apalcillin is a pseudomonas-active penicillin with a broad spectrum of antibacterial activity similar to that of piperacillin , except for the greater potency of apalcillin against acinetobacter spp . and pseudomonas aeruginosa . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
71,
84
]
} | {
"id": "C0031955",
"name": "piperacillin",
"pos": [
113,
125
]
} |
a total of 21 strains from nine outbreaks were resistant to one or more of the following antimicrobial agents : tetracycline , metronidazole , ampicillin , or carbenicillin . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial agents",
"pos": [
89,
109
]
} | {
"id": "C0039644",
"name": "tetracycline",
"pos": [
112,
124
]
} |
a total of 21 strains from nine outbreaks were resistant to one or more of the following antimicrobial agents : tetracycline , metronidazole , ampicillin , or carbenicillin . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial agents",
"pos": [
89,
109
]
} | {
"id": "C0025872",
"name": "metronidazole",
"pos": [
127,
140
]
} |
syntheses and specific activity determinations of no-carrier-added ( nca ) f-18-labeled butyrophenone neuroleptics -- benperidol , haloperidol , spiroperidol , and pipamperone . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
102,
114
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
131,
142
]
} |
a general method for the syntheses of no-carrier-added ( nca ) 18f-labeled butyrophenone neuroleptics -- benperidol , haloperidol , spiroperidol , and pipamperone is described . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
89,
101
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
118,
129
]
} |
none showed antibacterial or antifungal activity , clearly demonstrating that substitution of the secondary hydroxyl group with fluorine abolishes the antibacterial activity of the parent compound , chloramphenicol . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
12,
25
]
} | {
"id": "C0008168",
"name": "chloramphenicol",
"pos": [
199,
214
]
} |
this finding sharply contrasts with that of previous workers , in which fluorination of the 3-hydroxyl group enhanced antibacterial activity against many chloramphenicol-resistant strains . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
118,
131
]
} | {
"id": "C0008168",
"name": "chloramphenicol",
"pos": [
154,
169
]
} |
nine benzimidazole anthelmintics-thiabendazole , mebendazole , fenbendazole , cambendazole , flubendazole , albendazole , parbendazole , oxibendazole , and oxfendazole -- were tested for their larvicidal effects and capabilities to inhibit migration of larval toxocara canis in mice . | therapeutic_class_of | {
"id": "C0003158",
"name": "anthelmintics",
"pos": [
19,
32
]
} | {
"id": "C0025023",
"name": "mebendazole",
"pos": [
49,
60
]
} |
nine benzimidazole anthelmintics-thiabendazole , mebendazole , fenbendazole , cambendazole , flubendazole , albendazole , parbendazole , oxibendazole , and oxfendazole -- were tested for their larvicidal effects and capabilities to inhibit migration of larval toxocara canis in mice . | therapeutic_class_of | {
"id": "C0003158",
"name": "anthelmintics",
"pos": [
19,
32
]
} | {
"id": "C0001911",
"name": "albendazole",
"pos": [
108,
119
]
} |
combinations of edta-tromethamine and 7 antimicrobial agents ( chloramphenicol , nalidixic acid , oxytetracycline , penicillin , polymyxin-b , streptomycin , or a combination of sulfamethazine , sulfapyridine , and sulfathiazole ) were tested for synergistic activities against proteus vulgaris of canine origin . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial agents",
"pos": [
40,
60
]
} | {
"id": "C0030092",
"name": "oxytetracycline",
"pos": [
98,
113
]
} |
particularly noteworthy was its significant antifungal activity which was comparable to the activity of the standard antifungal antibiotic amphotericin b . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
44,
54
]
} | {
"id": "C0002679",
"name": "amphotericin b",
"pos": [
139,
153
]
} |
ampicillin-guaiacolsulfonate , a new derivative of ampicillin , preserves the antibacterial properties of ampicillin , is suitable for infection owing to its good water solubility and it has far higher stability in dry state than has sodium ampicillin . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
78,
91
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
241,
251
]
} |
the cardiovascular effects of a new antiarrhythmic drug derived from the local anaesthetics glycerol-1- ( 2-diethylaminoethylether ) -3- ( 2-methoxyphenylether ) ( brufacain ) , was examined on 10 anaesthetized cats and compared in parallel experiments to alpha-diethylamino-acetate-2,6-xylidide ( lidocaine ) . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
36,
50
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
298,
307
]
} |
now we are reporting the slight depression of epsp and pss and the prevention of the appearance of penicillin-induced pss by an antiepileptic drug sodium dipropylacetate ( depakine ) . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drug",
"pos": [
128,
146
]
} | {
"id": "C0037567",
"name": "sodium dipropylacetate",
"pos": [
147,
169
]
} |
a possible relationship between folate and monoamine metabolism is discussed with particular reference to the antiepileptic and toxic effects of phenobarbitone , diphenylhydantoin and primidone . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic",
"pos": [
110,
123
]
} | {
"id": "C0031507",
"name": "diphenylhydantoin",
"pos": [
162,
179
]
} |
a possible relationship between folate and monoamine metabolism is discussed with particular reference to the antiepileptic and toxic effects of phenobarbitone , diphenylhydantoin and primidone . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic",
"pos": [
110,
123
]
} | {
"id": "C0033148",
"name": "primidone",
"pos": [
184,
193
]
} |
subsequent trials with other anti-malarial drugs indicated that the chloroquine-resistant p. falciparum were also resistant to one day therapy with pyrimethamine 50 mg. or sulphamethoxypyridazine 1 g given singly ; | therapeutic_class_of | {
"id": "C0003374",
"name": "anti-malarial",
"pos": [
29,
42
]
} | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
68,
79
]
} |
the effects of the similarily structured antidepressant drugs imipramine and dimetacrine and their demethylated derivatives on myocardial performance were studied in vitro on 42 right ventricular papillary muscles of cats . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
41,
55
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
62,
72
]
} |
the antidepressants ipindole , imipramine , clomipramine , 1-chloro-amitriptyline , and 1-chloro-10,11-dehydro-amitriptyline were found to cause an accumulation of intraalveolar foam cells accompanied by the formation of abnormal lamellated and crystalloid cytoplasmic inclusions in most pulmonary and hepatic cell types . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
4,
19
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
31,
41
]
} |
the antidepressants ipindole , imipramine , clomipramine , 1-chloro-amitriptyline , and 1-chloro-10,11-dehydro-amitriptyline were found to cause an accumulation of intraalveolar foam cells accompanied by the formation of abnormal lamellated and crystalloid cytoplasmic inclusions in most pulmonary and hepatic cell types . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
4,
19
]
} | {
"id": "C0009010",
"name": "clomipramine",
"pos": [
44,
56
]
} |
the antidepressants ipindole , imipramine , clomipramine , 1-chloro-amitriptyline , and 1-chloro-10,11-dehydro-amitriptyline were found to cause an accumulation of intraalveolar foam cells accompanied by the formation of abnormal lamellated and crystalloid cytoplasmic inclusions in most pulmonary and hepatic cell types . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
4,
19
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
111,
124
]
} |
a comparison was made on alert rabbits between the nature of spike activity of normal cortical neurones and of those after a two-week daily administration of neuroleptics , namely chlorpromazine , trifluoperazine and haloperidol in 1 and 5 mg/kg doses . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
158,
170
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
217,
228
]
} |
effectiveness of antibacterial drugs from the group of aminoglycoside antibiotics , i.e . kanamycin , gentamycin and tobramycin with respect to the main causative agents of surgical infections , i.e . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial drugs",
"pos": [
17,
36
]
} | {
"id": "C0022487",
"name": "kanamycin",
"pos": [
90,
99
]
} |
effectiveness of antibacterial drugs from the group of aminoglycoside antibiotics , i.e . kanamycin , gentamycin and tobramycin with respect to the main causative agents of surgical infections , i.e . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial drugs",
"pos": [
17,
36
]
} | {
"id": "C0040341",
"name": "tobramycin",
"pos": [
117,
127
]
} |
the object of investigations was also the influence of antidepressants ( phthoracizine and imipramine ) and of the cholinolytic spasmolytin ( diphacyl ) on processes of the ne accumulation . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
55,
70
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
91,
101
]
} |
the concentrations of 11 amino acids were determined in 9 regions of the rat brain following the acute administration of the antidepressant drugs imipramine and org . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
125,
139
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
146,
156
]
} |
several antibacterial drugs , including erythromycin , chloramphenicol , clindamycin , rifampin and tetracycline , demonstrated significant antiparasitic effects at concentrations within or near those observed during therapy in vivo ; | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial drugs",
"pos": [
8,
27
]
} | {
"id": "C0008168",
"name": "chloramphenicol",
"pos": [
55,
70
]
} |
several antibacterial drugs , including erythromycin , chloramphenicol , clindamycin , rifampin and tetracycline , demonstrated significant antiparasitic effects at concentrations within or near those observed during therapy in vivo ; | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial drugs",
"pos": [
8,
27
]
} | {
"id": "C0008947",
"name": "clindamycin",
"pos": [
73,
84
]
} |
several antibacterial drugs , including erythromycin , chloramphenicol , clindamycin , rifampin and tetracycline , demonstrated significant antiparasitic effects at concentrations within or near those observed during therapy in vivo ; | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial drugs",
"pos": [
8,
27
]
} | {
"id": "C0035608",
"name": "rifampin",
"pos": [
87,
95
]
} |
the eye made an excellent response to treatment with the new antifungal drug , ketoconazole , and 5-fluorocytosine . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal drug",
"pos": [
61,
76
]
} | {
"id": "C0022625",
"name": "ketoconazole",
"pos": [
79,
91
]
} |
the eye made an excellent response to treatment with the new antifungal drug , ketoconazole , and 5-fluorocytosine . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal drug",
"pos": [
61,
76
]
} | {
"id": "C0016278",
"name": "5-fluorocytosine",
"pos": [
98,
114
]
} |
a rapid and reliable high-performance liquid chromatographic ( hplc ) assay has been developed for the measurement of the antiarrhythmic drug , amiodarone ( a ) , and its metabolite , n-desethyl-amiodarone ( nda ) , in serum . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drug",
"pos": [
122,
141
]
} | {
"id": "C0002598",
"name": "amiodarone",
"pos": [
195,
205
]
} |
serum and urine antibacterial activity reflected the concentration of cefotaxime and mic of the bacterial pathogens tested . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
16,
29
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
70,
80
]
} |
in vitro antibacterial activity of cefmenoxime was superior to 18 other antibiotics , including cefotiam and cefotaxime tested in this study . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
9,
22
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
109,
119
]
} |
the study confirms the good antiarrhythmic effect of disopyramide and shows that the cr preparation permits twice daily administration of disopyramide . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
28,
42
]
} | {
"id": "C0012702",
"name": "disopyramide",
"pos": [
138,
150
]
} |
the in vitro antibacterial activity of brl 17421 ( temocillin ) , a new penicillin , was determined in quantitative serial broth dilution tests and was compared to that of mezlocillin , piperacillin , cefazolin and cefotaxime against 751 clinical isolates of the enterobacteriaceae family . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
13,
26
]
} | {
"id": "C0031955",
"name": "piperacillin",
"pos": [
186,
198
]
} |
the in vitro antibacterial activity of brl 17421 ( temocillin ) , a new penicillin , was determined in quantitative serial broth dilution tests and was compared to that of mezlocillin , piperacillin , cefazolin and cefotaxime against 751 clinical isolates of the enterobacteriaceae family . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
13,
26
]
} | {
"id": "C0007546",
"name": "cefazolin",
"pos": [
201,
210
]
} |
the in vitro antibacterial activity of brl 17421 ( temocillin ) , a new penicillin , was determined in quantitative serial broth dilution tests and was compared to that of mezlocillin , piperacillin , cefazolin and cefotaxime against 751 clinical isolates of the enterobacteriaceae family . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
13,
26
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
215,
225
]
} |
the antifungal drug , miconazole nitrate , was found to possess anti-dandruff activity similar to selenium sulfide , a cytostatic compound . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal drug",
"pos": [
4,
19
]
} | {
"id": "C0086620",
"name": "miconazole nitrate",
"pos": [
22,
40
]
} |
the in-vitro antibacterial activity of cefotetan was assessed against recent clinical isolates of common bacteria and also against reference strains that produced known beta-lactamases . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
13,
26
]
} | {
"id": "C0007555",
"name": "cefotetan",
"pos": [
39,
48
]
} |
the antibacterial activity of cefotetan , a new cephamycin , was compared with that of cephalothin , cefoxitin , cefamandole , cefoperazone and cefotaxime on 12 substrains of escherichia coli k12 bm13 harbouring single and multi-copy plasmids coding for plasmid-mediated beta-lactamases tem , shvi , oxa-i and oxa-iii . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0007555",
"name": "cefotetan",
"pos": [
30,
39
]
} |
the antibacterial activity of cefotetan , a new cephamycin , was compared with that of cephalothin , cefoxitin , cefamandole , cefoperazone and cefotaxime on 12 substrains of escherichia coli k12 bm13 harbouring single and multi-copy plasmids coding for plasmid-mediated beta-lactamases tem , shvi , oxa-i and oxa-iii . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0007557",
"name": "cefoxitin",
"pos": [
101,
110
]
} |
the antibacterial activity of cefotetan , a new cephamycin , was compared with that of cephalothin , cefoxitin , cefamandole , cefoperazone and cefotaxime on 12 substrains of escherichia coli k12 bm13 harbouring single and multi-copy plasmids coding for plasmid-mediated beta-lactamases tem , shvi , oxa-i and oxa-iii . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0007552",
"name": "cefoperazone",
"pos": [
127,
139
]
} |
the antibacterial activity of cefotetan , a new cephamycin , was compared with that of cephalothin , cefoxitin , cefamandole , cefoperazone and cefotaxime on 12 substrains of escherichia coli k12 bm13 harbouring single and multi-copy plasmids coding for plasmid-mediated beta-lactamases tem , shvi , oxa-i and oxa-iii . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
144,
154
]
} |
cefotetan was noted to have a broader spectrum of activity than cefoxitin and its antibacterial activity was comparable to that of cefotaxime and moxalactam . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
82,
95
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
131,
141
]
} |
the object of this investigation was to evaluate the antibacterial properties of the cephalosporins cefoxitin , cefoperazone , cefotaxime and of gentamicin , in comparison with cefotetan , a new cephamycin with a high degree of stability to beta-lactamases . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
53,
66
]
} | {
"id": "C0007557",
"name": "cefoxitin",
"pos": [
100,
109
]
} |
the object of this investigation was to evaluate the antibacterial properties of the cephalosporins cefoxitin , cefoperazone , cefotaxime and of gentamicin , in comparison with cefotetan , a new cephamycin with a high degree of stability to beta-lactamases . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
53,
66
]
} | {
"id": "C0007552",
"name": "cefoperazone",
"pos": [
112,
124
]
} |
the object of this investigation was to evaluate the antibacterial properties of the cephalosporins cefoxitin , cefoperazone , cefotaxime and of gentamicin , in comparison with cefotetan , a new cephamycin with a high degree of stability to beta-lactamases . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
53,
66
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
127,
137
]
} |
the object of this investigation was to evaluate the antibacterial properties of the cephalosporins cefoxitin , cefoperazone , cefotaxime and of gentamicin , in comparison with cefotetan , a new cephamycin with a high degree of stability to beta-lactamases . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
53,
66
]
} | {
"id": "C0007555",
"name": "cefotetan",
"pos": [
177,
186
]
} |
neuroleptic binding sites : specific labeling in mice with [ 18f ] haloperidol , a potential tracer for positron emission tomography . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
0,
11
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
67,
78
]
} |
all isolates were sensitive to a wide range of antimicrobial agents , with the exception of nalidixic acid and polymyxin , but one group was resistant to metronidazole . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial agents",
"pos": [
47,
67
]
} | {
"id": "C0025872",
"name": "metronidazole",
"pos": [
154,
167
]
} |
acute and chronic effects of the antidepressant drugs tranylcypromine , a monoamine oxidase inhibitor , and amitriptyline , a monoamine uptake inhibitor , were studied on beta-adrenergic receptor function in mouse astrocytes in primary cultures . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
33,
47
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
108,
121
]
} |
the antibacterial agents tested were as follows : ampicillin , sulbenicillin , piperacillin , mezlocillin , cefazolin , cefmetazole , cefoperazone , cefotaxime , ceftizoxime , kanamycin , gentamicin , tobramycin , amikacin , tetracycline , doxycycline , minocycline , nalidixic acid , pipemidic acid , erythromycin and clindamycin . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial agents",
"pos": [
4,
24
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
50,
60
]
} |
the antibacterial agents tested were as follows : ampicillin , sulbenicillin , piperacillin , mezlocillin , cefazolin , cefmetazole , cefoperazone , cefotaxime , ceftizoxime , kanamycin , gentamicin , tobramycin , amikacin , tetracycline , doxycycline , minocycline , nalidixic acid , pipemidic acid , erythromycin and clindamycin . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial agents",
"pos": [
4,
24
]
} | {
"id": "C0031955",
"name": "piperacillin",
"pos": [
79,
91
]
} |
the antibacterial agents tested were as follows : ampicillin , sulbenicillin , piperacillin , mezlocillin , cefazolin , cefmetazole , cefoperazone , cefotaxime , ceftizoxime , kanamycin , gentamicin , tobramycin , amikacin , tetracycline , doxycycline , minocycline , nalidixic acid , pipemidic acid , erythromycin and clindamycin . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial agents",
"pos": [
4,
24
]
} | {
"id": "C0007546",
"name": "cefazolin",
"pos": [
108,
117
]
} |
the antibacterial agents tested were as follows : ampicillin , sulbenicillin , piperacillin , mezlocillin , cefazolin , cefmetazole , cefoperazone , cefotaxime , ceftizoxime , kanamycin , gentamicin , tobramycin , amikacin , tetracycline , doxycycline , minocycline , nalidixic acid , pipemidic acid , erythromycin and clindamycin . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial agents",
"pos": [
4,
24
]
} | {
"id": "C0007552",
"name": "cefoperazone",
"pos": [
134,
146
]
} |
the antibacterial agents tested were as follows : ampicillin , sulbenicillin , piperacillin , mezlocillin , cefazolin , cefmetazole , cefoperazone , cefotaxime , ceftizoxime , kanamycin , gentamicin , tobramycin , amikacin , tetracycline , doxycycline , minocycline , nalidixic acid , pipemidic acid , erythromycin and clindamycin . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial agents",
"pos": [
4,
24
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
149,
159
]
} |
the antibacterial agents tested were as follows : ampicillin , sulbenicillin , piperacillin , mezlocillin , cefazolin , cefmetazole , cefoperazone , cefotaxime , ceftizoxime , kanamycin , gentamicin , tobramycin , amikacin , tetracycline , doxycycline , minocycline , nalidixic acid , pipemidic acid , erythromycin and clindamycin . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial agents",
"pos": [
4,
24
]
} | {
"id": "C0007560",
"name": "ceftizoxime",
"pos": [
162,
173
]
} |
the antibacterial agents tested were as follows : ampicillin , sulbenicillin , piperacillin , mezlocillin , cefazolin , cefmetazole , cefoperazone , cefotaxime , ceftizoxime , kanamycin , gentamicin , tobramycin , amikacin , tetracycline , doxycycline , minocycline , nalidixic acid , pipemidic acid , erythromycin and clindamycin . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial agents",
"pos": [
4,
24
]
} | {
"id": "C0022487",
"name": "kanamycin",
"pos": [
176,
185
]
} |
the antibacterial agents tested were as follows : ampicillin , sulbenicillin , piperacillin , mezlocillin , cefazolin , cefmetazole , cefoperazone , cefotaxime , ceftizoxime , kanamycin , gentamicin , tobramycin , amikacin , tetracycline , doxycycline , minocycline , nalidixic acid , pipemidic acid , erythromycin and clindamycin . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial agents",
"pos": [
4,
24
]
} | {
"id": "C0040341",
"name": "tobramycin",
"pos": [
201,
211
]
} |
the antibacterial agents tested were as follows : ampicillin , sulbenicillin , piperacillin , mezlocillin , cefazolin , cefmetazole , cefoperazone , cefotaxime , ceftizoxime , kanamycin , gentamicin , tobramycin , amikacin , tetracycline , doxycycline , minocycline , nalidixic acid , pipemidic acid , erythromycin and clindamycin . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial agents",
"pos": [
4,
24
]
} | {
"id": "C0002499",
"name": "amikacin",
"pos": [
214,
222
]
} |
the antibacterial agents tested were as follows : ampicillin , sulbenicillin , piperacillin , mezlocillin , cefazolin , cefmetazole , cefoperazone , cefotaxime , ceftizoxime , kanamycin , gentamicin , tobramycin , amikacin , tetracycline , doxycycline , minocycline , nalidixic acid , pipemidic acid , erythromycin and clindamycin . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial agents",
"pos": [
4,
24
]
} | {
"id": "C0008947",
"name": "clindamycin",
"pos": [
319,
330
]
} |
the antibacterial activity of ctx was not influenced by the transfer of 25 different plasmids to e. coli ml1410 . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0007554",
"name": "ctx",
"pos": [
30,
33
]
} |
we performed a retrospective study of the effect of antidepressant treatment with doxepin on seizure frequency . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
52,
66
]
} | {
"id": "C0013085",
"name": "doxepin",
"pos": [
82,
89
]
} |
on the other hand diazepam and neuroleptic agents such as pimozide and flupentixol failed to antagonize the clonidine effects . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic agents",
"pos": [
31,
49
]
} | {
"id": "C0031935",
"name": "pimozide",
"pos": [
58,
66
]
} |
the antibacterial activity of combinations of mecillinam and ampicillin in vitro and in normal and granulopenic mice . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
61,
71
]
} |
the antibacterial activity of mecillinam and ampicillin , alone and in combination , against escherichia coli was quantitated and compared in vitro and in vivo . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
45,
55
]
} |
the concept of a dual biochemical mechanism , i.e . incorporation of 5fu into rna and formation of 5-fluorodeoxy ump leading to inhibition of dna synthesis , previously proposed for the antifungal action of 5fc is also applicable to the action of 5fc and 5fu on the dematiaceous fungi . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
186,
196
]
} | {
"id": "C0016278",
"name": "5fc",
"pos": [
247,
250
]
} |
simultaneous liquid chromatographic determination of chloramphenicol and antiepileptic drugs ( phenobarbital , phenytoin , carbamazepine , and primidone ) in plasma . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drugs",
"pos": [
73,
92
]
} | {
"id": "C0031507",
"name": "phenytoin",
"pos": [
111,
120
]
} |
simultaneous liquid chromatographic determination of chloramphenicol and antiepileptic drugs ( phenobarbital , phenytoin , carbamazepine , and primidone ) in plasma . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drugs",
"pos": [
73,
92
]
} | {
"id": "C0033148",
"name": "primidone",
"pos": [
143,
152
]
} |
a method for the simultaneous analysis of chloramphenicol and four antiepileptic drugs ( phenobarbital , phenytoin , carbamazepine , and primidone ) in plasma by high-performance liquid chromatography ( hplc ) is described . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic",
"pos": [
67,
80
]
} | {
"id": "C0031507",
"name": "phenytoin",
"pos": [
105,
114
]
} |
a method for the simultaneous analysis of chloramphenicol and four antiepileptic drugs ( phenobarbital , phenytoin , carbamazepine , and primidone ) in plasma by high-performance liquid chromatography ( hplc ) is described . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic",
"pos": [
67,
80
]
} | {
"id": "C0033148",
"name": "primidone",
"pos": [
137,
146
]
} |
we conclude that electrophysiologic properties of napa are slightly different from those of procainamide and that napa is not uniformly effective for suppressing ventricular dysrhythmias , but its antiarrhythmic mechanisms are similar to those of procainamide . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
197,
211
]
} | {
"id": "C0033216",
"name": "procainamide",
"pos": [
247,
259
]
} |
the antibacterial activity of teichomycin , a glycopeptide antibiotic similar to vancomycin , has been evaluated in vitro and compared with that of vancomycin . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0042313",
"name": "vancomycin",
"pos": [
148,
158
]
} |
the in vitro activity of sch 29,482 , a new oral beta-lactam antimicrobial agent , was compared with those of norfloxacin , rosoxacin , ampicillin , erythromycin , and tetracycline against 142 neisseria gonorrhoeae strains . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial agent",
"pos": [
61,
80
]
} | {
"id": "C0028365",
"name": "norfloxacin",
"pos": [
110,
121
]
} |
the in vitro activity of sch 29,482 , a new oral beta-lactam antimicrobial agent , was compared with those of norfloxacin , rosoxacin , ampicillin , erythromycin , and tetracycline against 142 neisseria gonorrhoeae strains . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial agent",
"pos": [
61,
80
]
} | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
149,
161
]
} |
the in vitro activity of sch 29,482 , a new oral beta-lactam antimicrobial agent , was compared with those of norfloxacin , rosoxacin , ampicillin , erythromycin , and tetracycline against 142 neisseria gonorrhoeae strains . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial agent",
"pos": [
61,
80
]
} | {
"id": "C0039644",
"name": "tetracycline",
"pos": [
168,
180
]
} |
conflicting evidence regarding the antagonistic action of folic acid ( fa ) on the efficiency of the antiepileptic drug diphenylhydantoin ( dph ) led us to study this problem in rats . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drug",
"pos": [
101,
119
]
} | {
"id": "C0031507",
"name": "diphenylhydantoin",
"pos": [
120,
137
]
} |
absorption of the antiarrhythmic agent mexiletine from conventional capsules ( 200 mg ) and two sustained-release formulations ( 360 and 432 mg ) was studied in four healthy volunteer subjects , and use of the 360-mg preparation was studied in nine patients who had been using conventional capsules . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agent",
"pos": [
18,
38
]
} | {
"id": "C0025887",
"name": "mexiletine",
"pos": [
39,
49
]
} |
the pharmacokinetics of phenylethylmalonamide ( pema ) , one of the major metabolites of the antiepileptic drug primidone , have been studied in 6 healthy volunteers after administration of single 500mg intravenous and oral doses . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drug",
"pos": [
93,
111
]
} | {
"id": "C0033148",
"name": "primidone",
"pos": [
112,
121
]
} |
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