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|---|---|---|---|
the antibacterial effect of neomycin , quaternary ammonium compounds and combinations of these substances on pseudomonas aeruginosa . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0027603",
"name": "neomycin",
"pos": [
28,
36
]
} |
the antimalarial activity of a new macrolide antibiotic , midecamycin , has been evaluated against a sensitive strain of plasmodium berghei , a chloroquine-resistant strain of p. yoelii nigeriensis and a simian parasite , p. cynomolgi b . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial",
"pos": [
4,
16
]
} | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
144,
155
]
} |
three weeks after starting treatment with the antidepressant trimipramine a 55-year-old man developed increasing cough , fatigue and lack of appetite . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
46,
60
]
} | {
"id": "C0041056",
"name": "trimipramine",
"pos": [
61,
73
]
} |
this paper investigates the effect kinetics of the opioid meperidine ( 150 mg , p.o . ) and the antidepressant imipramine ( 100 mg , p.o . ) on spontaneous and evoked eeg activity in a placebo-controlled double-blind cross-over study with 20 healthy male subjects . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
96,
110
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
111,
121
]
} |
antiepileptic drugs such as vigabatrin [ gamma vinyl gaba ( gvg ) ] , a drug rationally developed to treat resistant epilepsy , can enhance gaba transmission in these regions and may thereby afford seizure protection . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drugs",
"pos": [
0,
19
]
} | {
"id": "C0048044",
"name": "gamma vinyl gaba",
"pos": [
41,
57
]
} |
the dependence of the antibacterial activity of the two oral cephalosporins cefixime and cefaclor on pharmacokinetic properties was investigated in an in vitro model using strains of enterobacteria and a streptococcal strain . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
22,
35
]
} | {
"id": "C0060400",
"name": "cefixime",
"pos": [
76,
84
]
} |
the dependence of the antibacterial activity of the two oral cephalosporins cefixime and cefaclor on pharmacokinetic properties was investigated in an in vitro model using strains of enterobacteria and a streptococcal strain . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
22,
35
]
} | {
"id": "C0007537",
"name": "cefaclor",
"pos": [
89,
97
]
} |
as a result of its antibacterial activity and pharmacokinetic properties cefixime can be administered less frequently than cefaclor . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
19,
32
]
} | {
"id": "C0060400",
"name": "cefixime",
"pos": [
73,
81
]
} |
as a result of its antibacterial activity and pharmacokinetic properties cefixime can be administered less frequently than cefaclor . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
19,
32
]
} | {
"id": "C0007537",
"name": "cefaclor",
"pos": [
123,
131
]
} |
the inhibitory effects of ics 205-930 ( 15 and 30 micrograms/kg s.c. ) on the drug-induced stimulation of da release could also be extended to the neuroleptic haloperidol ( 0.1 mg/kg s.c. ) . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
147,
158
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
159,
170
]
} |
the literature concerning the relationship between ep and the therapeutically important classes of psychoactive drugs ( stimulants , neuroleptics , antidepressants , minor tranquilizers/sedatives , lithium salts , carbamazepine ) was reviewed . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
148,
163
]
} | {
"id": "C0006949",
"name": "carbamazepine",
"pos": [
214,
227
]
} |
the authors report the results of open-label antidepressant trials in a series of normal weight bulimic women who showed an inadequate response to an initial trial of imipramine hydrochloride as part of a treatment comparison study . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
45,
59
]
} | {
"id": "C0589978",
"name": "imipramine hydrochloride",
"pos": [
167,
191
]
} |
plasma levels of antiepileptic drugs were measured with the help of the abbott tdx analyzer and after administration of carbamazepine ( 20 mg/kg ) , diphenylhydantoin ( 10 mg/kg ) , phenobarbital ( 25 mg/kg ) , and valproate ( 250 mg/kg ) were as follows : 8.61 , 6.48 , 24.3 and 329 micrograms/ml , respectively . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drugs",
"pos": [
17,
36
]
} | {
"id": "C0031507",
"name": "diphenylhydantoin",
"pos": [
149,
166
]
} |
the classical neuroleptic drugs haloperidol and pimozide have a strong disruptive effect on the acquisition of conditioned avoidance responding ( car ) , yet have relatively little impact on the performance of previously acquired responses . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic drugs",
"pos": [
14,
31
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
32,
43
]
} |
the classical neuroleptic drugs haloperidol and pimozide have a strong disruptive effect on the acquisition of conditioned avoidance responding ( car ) , yet have relatively little impact on the performance of previously acquired responses . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic drugs",
"pos": [
14,
31
]
} | {
"id": "C0031935",
"name": "pimozide",
"pos": [
48,
56
]
} |
these results suggest that different mechanisms are involved in the expression of cataleptic behaviour during chronic treatment with sch 23390 and classical antipsychotics , such as haloperidol . | therapeutic_class_of | {
"id": "C0040615",
"name": "antipsychotics",
"pos": [
157,
171
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
182,
193
]
} |
a case of epididymitis developed in a 33 year old man after treatment with the anti-arrhythmic agent , amiodarone , for approximately 18 months . | therapeutic_class_of | {
"id": "C0003195",
"name": "anti-arrhythmic agent",
"pos": [
79,
100
]
} | {
"id": "C0002598",
"name": "amiodarone",
"pos": [
103,
113
]
} |
we report two cases , one of whom suffered slight symptoms only while the other was disabled by the arrhythmia in spite of treatment with numerous antiarrhythmic drugs including amiodarone . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
147,
161
]
} | {
"id": "C0002598",
"name": "amiodarone",
"pos": [
178,
188
]
} |
metabolites of the antimycobacterial agent 4-deoxo-3,4- [ 2-spiro- ( n-isobutyl-4-piperidyl ) ] - ( 1h ) -imidazo- ( 2,5-dihydro ) - rifamycin s ( rifabutin ) were isolated from human urine after administration of a single oral dose of the drug . | therapeutic_class_of | {
"id": "C0360390",
"name": "antimycobacterial agent",
"pos": [
19,
42
]
} | {
"id": "C0140575",
"name": "rifabutin",
"pos": [
147,
156
]
} |
mice received a single teratogenic dose of the antiepileptic drug valproic acid ( vpa ; 500 mg/kg i.p . ) on 8th d of pregnancy . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic",
"pos": [
47,
60
]
} | {
"id": "C0042291",
"name": "vpa",
"pos": [
82,
85
]
} |
comparative effects of the antidepressants amitriptyline , mianserin and adinazolam on hemodynamics and ecg in myocardial infarcted dogs . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
27,
42
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
43,
56
]
} |
this study was undertaken to examine the effects of mianserin ( mia ) , a tetracyclic antidepressant , and adinazolam ( adi ) , a new benzodiazepine antidepressant on cardiac function and electrocardiogram in normal and infarcted hearts of anesthetized dogs , and to compare the effects with those of amitriptyline , a commonly used tricyclic antidepressant . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
86,
100
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
301,
314
]
} |
the effects of the local anaesthetics procaine , tetracaine and lidocaine and of the antidepressant imipramine on human erythrocyte acetylcholinesterase were investigated . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
85,
99
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
100,
110
]
} |
antiarrhythmic therapy with amiodarone hydrochloride may produce a pattern of vortex corneal epitheliopathy or cornea verticillata . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
0,
14
]
} | {
"id": "C0700442",
"name": "amiodarone hydrochloride",
"pos": [
28,
52
]
} |
an antiarrhythmic drug , amiodarone , contains 37 % iodine by weight and is structurally similar to the thyroid hormones . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drug",
"pos": [
3,
22
]
} | {
"id": "C0002598",
"name": "amiodarone",
"pos": [
25,
35
]
} |
at present , this applies to tricyclic antidepressants and to certain neuroleptics ( e.g . perphenazine and thioridazine ) and antiarrhythmics ( e.g . propafenone and flecainide ) . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmics",
"pos": [
127,
142
]
} | {
"id": "C0033429",
"name": "propafenone",
"pos": [
151,
162
]
} |
at present , this applies to tricyclic antidepressants and to certain neuroleptics ( e.g . perphenazine and thioridazine ) and antiarrhythmics ( e.g . propafenone and flecainide ) . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmics",
"pos": [
127,
142
]
} | {
"id": "C0016229",
"name": "flecainide",
"pos": [
167,
177
]
} |
experimental infusion applications of the cancer chemotherapeutic agents cisplatin and carboplatin and the antimicrobials tetracycline and doxycycline are reported herein . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobials",
"pos": [
107,
121
]
} | {
"id": "C0039644",
"name": "tetracycline",
"pos": [
122,
134
]
} |
the antiarrhythmic response to procainamide was not significantly altered by napa in seven of nine patients . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
4,
18
]
} | {
"id": "C0033216",
"name": "procainamide",
"pos": [
31,
43
]
} |
acute electrophysiologic effects and antiarrhythmic/antifibrillatory activity of intravenous amiodarone in a chronic feline infarction model . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
37,
51
]
} | {
"id": "C0002598",
"name": "amiodarone",
"pos": [
93,
103
]
} |
because ventricular arrhythmia substrate may differ in acute and chronic ischemic heart disease , we investigated the acute electrophysiologic and antiarrhythmic/antifibrillatory effects of intravenously ( i.v . ) administered amiodarone in nine chronically infarcted cats . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
147,
161
]
} | {
"id": "C0002598",
"name": "amiodarone",
"pos": [
227,
237
]
} |
the reduction of pain by two antidepressants , clomipramine and mianserin , was , in this study on 253 patients with chronic idiopathic pain syndrome , found to be not better than a placebo when all patients were compared independently of the classification of pain . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
29,
44
]
} | {
"id": "C0009010",
"name": "clomipramine",
"pos": [
47,
59
]
} |
the effects of several antidepressants ( desmethylimipramine , amitriptyline and bupropion ) on escape deficits induced by inescapable shock were assessed in four strains of mice . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
23,
38
]
} | {
"id": "C0011685",
"name": "desmethylimipramine",
"pos": [
41,
60
]
} |
the effects of several antidepressants ( desmethylimipramine , amitriptyline and bupropion ) on escape deficits induced by inescapable shock were assessed in four strains of mice . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
23,
38
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
63,
76
]
} |
[ effect of a combined antibacterial therapy using sulfamethoxazole and trimethoprim on the metabolism of diabetics ] . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
23,
36
]
} | {
"id": "C0041041",
"name": "trimethoprim",
"pos": [
72,
84
]
} |
the anthelmintic effect of mebendazol was also tested at 18 geese naturally infected with amidostomum anseris , trichostrongylus tenuis , capillaria anatis , hymenolepis lanceolata and hymenolepis setigera . | therapeutic_class_of | {
"id": "C0003158",
"name": "anthelmintic",
"pos": [
4,
16
]
} | {
"id": "C0025023",
"name": "mebendazol",
"pos": [
27,
37
]
} |
the antifungal agents nystatin and amphotericin b were non-toxic to protoplasts at concentrations that controlled fungal growth ( 25 units and 2.5 mug/ml respectively ) . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal agents",
"pos": [
4,
21
]
} | {
"id": "C0002679",
"name": "amphotericin b",
"pos": [
35,
49
]
} |
of the antibacterial agents examined , only carbenicillin and , to a lesser extent , gentamicin were active against the bacteria usually encountered whilst still permitting normal protoplast metabolism and regeneration . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
7,
20
]
} | {
"id": "C0006976",
"name": "carbenicillin",
"pos": [
44,
57
]
} |
pharmacokinetics , antiarrhythmic effects , and tissue concentrations of amiodarone and desethylamiodarone in dogs with acute coronary artery occlusion . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
19,
33
]
} | {
"id": "C0002598",
"name": "amiodarone",
"pos": [
96,
106
]
} |
similarly , the antibacterial activity of penicillin g , oxacillin , cephalothin and cefamandole against staphylococcus aureus was augmented by misg . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
16,
29
]
} | {
"id": "C0030827",
"name": "penicillin",
"pos": [
42,
52
]
} |
similarly , the antibacterial activity of penicillin g , oxacillin , cephalothin and cefamandole against staphylococcus aureus was augmented by misg . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
16,
29
]
} | {
"id": "C0029983",
"name": "oxacillin",
"pos": [
57,
66
]
} |
forty-two patients with depression and epilepsy were entered into an antidepressant trial of amitriptyline , nomifensine and placebo . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
69,
83
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
93,
106
]
} |
effects of antifungal agents on ergosterol biosynthesis in candida albicans and trichophyton mentagrophytes : differential inhibitory sites of naphthiomate and miconazole . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal agents",
"pos": [
11,
28
]
} | {
"id": "C0025942",
"name": "miconazole",
"pos": [
160,
170
]
} |
the effect of repeated s.c. administration of various neuroleptics ( haloperidol , sulpiride and cis-flupentixol ) on the in vivo release and metabolism of dopamine ( da ) was studied in freely moving rats using trans striatal dialysis coupled to reverse-phase high-pressure liquid chromatography with electrochemical detection . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
54,
66
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
69,
80
]
} |
a double blind placebo controlled trial was carried out over a 6-month period on 17 patients with ankylosing spondylitis ( as ) to assess the effect of the second line antirheumatic drug , d-penicillamine . | therapeutic_class_of | {
"id": "C0003191",
"name": "antirheumatic",
"pos": [
168,
181
]
} | {
"id": "C0030817",
"name": "penicillamine",
"pos": [
191,
204
]
} |
after the intraventricular administration of neuroleptics , a dissociated antagonist efficacy appeared for haloperidol , but that of sulpiride and amisulpride became much more marked than after their intraperitoneal injection . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
45,
57
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
107,
118
]
} |
after discontinuation of enzyme-inducing aeds , serum vpa concentrations can be maintained with a lower vpa dosage given less frequently . | therapeutic_class_of | {
"id": "C0003299",
"name": "aeds",
"pos": [
41,
45
]
} | {
"id": "C0042291",
"name": "vpa",
"pos": [
104,
107
]
} |
the antiepileptic drug valproic acid ( vpa ) reduces the occurrence of the rhythmic and synchronous bursts produced by hippocampal neurons maintained 'in vitro ' and bathed in ringer-containing low-ca2+ ( 0.2 mm ) , high-mg2+ ( 4.0 mm ) . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drug",
"pos": [
4,
22
]
} | {
"id": "C0042291",
"name": "valproic acid",
"pos": [
23,
36
]
} |
in the present study , we investigated whether administration of guanidinoethane sulfonate , and inhibitor of taurine uptake , worsens electroshock-induced convulsions or modifies the antiepileptic actions of phenobarbital or phenytoin against maximal electroshock seizures in mice . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic",
"pos": [
184,
197
]
} | {
"id": "C0031507",
"name": "phenytoin",
"pos": [
226,
235
]
} |
on the other hand , the antiepileptic potency of phenobarbital and phenytoin against tonic convulsions of maximal electroshock seizures in mice was significantly lessened by chronic administration of guanidinoethane sulfonate . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic",
"pos": [
24,
37
]
} | {
"id": "C0031507",
"name": "phenytoin",
"pos": [
67,
76
]
} |
quantitative vibration perception threshold ( vpt ) measurements were performed on 134 healthy subjects and 147 epileptics undergoing prolonged ( more than one year ) antiepileptic treatment , 28 patients received diphenylhydantoin , 71 carbamazepine and 11 some other drug . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic",
"pos": [
167,
180
]
} | {
"id": "C0031507",
"name": "diphenylhydantoin",
"pos": [
214,
231
]
} |
by its pragmatic conception , modifications obtained by psychoactive agents are used ( antidepressants of the group imipramine and imao , classical benzodiazepines and alprazolam , provocation controlled in laboratory ) in order to strengthen innovating hypotheses and allow to elaborate useful treatment strategies for neuroses . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
87,
102
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
116,
126
]
} |
the antiarrhythmic effects of mexiletine ( n = 14 ) were compared to procainamide ( n = 16 ) by a double-blind parallel protocol in 30 patients ( group i ) with frequent premature ventricular contractions ( pvcs ) ( greater than 20/hr ) , and to amiodarone by an open-label sequential approach in 25 patients ( mean left ventricular ejection fraction of 32.6 +/- 13.4 % ) with life-threatening ventricular arrhythmias ( group ii ) resistant to two or more conventional agents . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
4,
18
]
} | {
"id": "C0025887",
"name": "mexiletine",
"pos": [
30,
40
]
} |
the antiarrhythmic effects of mexiletine ( n = 14 ) were compared to procainamide ( n = 16 ) by a double-blind parallel protocol in 30 patients ( group i ) with frequent premature ventricular contractions ( pvcs ) ( greater than 20/hr ) , and to amiodarone by an open-label sequential approach in 25 patients ( mean left ventricular ejection fraction of 32.6 +/- 13.4 % ) with life-threatening ventricular arrhythmias ( group ii ) resistant to two or more conventional agents . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
4,
18
]
} | {
"id": "C0033216",
"name": "procainamide",
"pos": [
69,
81
]
} |
the antiarrhythmic effects of mexiletine ( n = 14 ) were compared to procainamide ( n = 16 ) by a double-blind parallel protocol in 30 patients ( group i ) with frequent premature ventricular contractions ( pvcs ) ( greater than 20/hr ) , and to amiodarone by an open-label sequential approach in 25 patients ( mean left ventricular ejection fraction of 32.6 +/- 13.4 % ) with life-threatening ventricular arrhythmias ( group ii ) resistant to two or more conventional agents . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
4,
18
]
} | {
"id": "C0002598",
"name": "amiodarone",
"pos": [
246,
256
]
} |
antiarrhythmic properties of n-acetylprocainamide ( napa ) , an active metabolite of procainamide , were studied in 12 patients with coronary artery disease who presented with cardiac arrest or documented sustained ventricular tachycardia ( vt ) . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
0,
14
]
} | {
"id": "C0033216",
"name": "procainamide",
"pos": [
85,
97
]
} |
the dose-response effectiveness for the prototype antiarrhythmic drugs , propranolol , quinidine and lidocaine in converting the induced ventricular fibrillation to sinus rhythm was determined . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
50,
64
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
87,
96
]
} |
the dose-response effectiveness for the prototype antiarrhythmic drugs , propranolol , quinidine and lidocaine in converting the induced ventricular fibrillation to sinus rhythm was determined . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
50,
64
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
101,
110
]
} |
effects of chlorpromazine and the antidepressant drugs amitriptyline , clomipramine and mianserin on the ca-depleted rat uterus . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant drugs",
"pos": [
34,
54
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
55,
68
]
} |
effects of chlorpromazine and the antidepressant drugs amitriptyline , clomipramine and mianserin on the ca-depleted rat uterus . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant drugs",
"pos": [
34,
54
]
} | {
"id": "C0009010",
"name": "clomipramine",
"pos": [
71,
83
]
} |
imid moreover displayed activity in behavioural tests used in specific screening for antidepressants , potentiating yohimbine toxicity in mice and antagonizing immobility time in the despair test , with a potency in some cases equal to imipramine . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
85,
100
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
236,
246
]
} |
the patients treated with combination of two or more antiepileptic drugs showed increased concentration of phenytoin in 9.1 % and side effects in 4.6 % . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drugs",
"pos": [
53,
72
]
} | {
"id": "C0031507",
"name": "phenytoin",
"pos": [
107,
116
]
} |
the action of the antiepileptic drug , phenytoin , on junctional transmission at various frequencies of synaptic activation was studied in frog nerve-muscle preparation . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drug",
"pos": [
18,
36
]
} | {
"id": "C0031507",
"name": "phenytoin",
"pos": [
39,
48
]
} |
the effects on human psychomotor performance of femoxetine ( femo ) , a 5-hydroxytryptamine-selective antidepressant , alone and in combination with alcohol ( etoh ) were compared with those of amitriptyline ( ami ) and placebo in a controlled double-blind crossover trial in 11 student volunteers . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
102,
116
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
194,
207
]
} |
immobility was reduced by antidepressant drugs , such as imipramine , desimipramine , iproniazid and mianserin injected 24 , 5 and again 1 h prior to behavioral testing . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant drugs",
"pos": [
26,
46
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
73,
83
]
} |
[ new neuroleptics ( r-1625 or haloperidol , md-2028 or halo-anisone , ro 4-0403 or taractan , and lg-206 or dominal ) in different types of anesthesia without narcosis or anesthesia in the waking state . indications in neurosurgical anesthesiology . place of analgesia in neuroleptanalgesia ] . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
6,
18
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
31,
42
]
} |
isolation from rat brain of a metabolic product , desmethylimipramine , that mediates the antidepressant activity of imipramine ( tofranil ) . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
90,
104
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
117,
127
]
} |
the dichloroacetyl group , one of the functional groups responsible for the antibacterial activity of chloramphenicol , has been inserted into various amines , and the dichloroacetamido-derivatives obtained have been studied against e. histolytica edm , candida albicans atcc 2091 , saccharomyces cerevisiae atcc 7921 , aspergillus niger nrrl 3 , trichomonas vaginalis and mycobacterium tuberculosis h ( 37 ) rv and atcc 607 . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
76,
89
]
} | {
"id": "C0008168",
"name": "chloramphenicol",
"pos": [
102,
117
]
} |
[ the antibacterial activity of benzylpenicillin , phenethicillin and methicillin in comparisons on 105 strains of coagulase-positive staphylococci ] . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
6,
19
]
} | {
"id": "C0030827",
"name": "benzylpenicillin",
"pos": [
32,
48
]
} |
[ the effect of antidepressants of the imipramine group on the higher nervous activity of the dog ] . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
16,
31
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
39,
49
]
} |
[ conformation effects on the drug activity . 3. synthesis and evaluation of the antibacterial activity of the treo-2- ( dichloracetamide ) -2-methyl-3- ( p-nitrophenyl ) butan-1,3-diol , analogue of 1,2-dimethylsubstituted chloramphenicol ] . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
81,
94
]
} | {
"id": "C0008168",
"name": "chloramphenicol",
"pos": [
224,
239
]
} |
initial medication-free levels of opioid activity were positively correlated with the degree of antidepressant response to carbamazepine . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
96,
110
]
} | {
"id": "C0006949",
"name": "carbamazepine",
"pos": [
123,
136
]
} |
[ contribution to the determination of four antimalarial molecules ( chloroquine , quinine , pyrimethamine , sulfadoxime ) mixed in biological fluids . i. spectrophotometry uv ( author 's transl ) ] . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial",
"pos": [
44,
56
]
} | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
69,
80
]
} |
antimalarial therapy is directed more and more towards the use of associated substances : pyrimethamine , sulfadoxime , quinine et chloroquine . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial",
"pos": [
0,
12
]
} | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
131,
142
]
} |
the antidepressants imipramine , clomipramine , desipramine and nomifensine showed approximately the same inhibitory potency against this uptake as against 5ht uptake in platelets . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
4,
19
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
20,
30
]
} |
the antidepressants imipramine , clomipramine , desipramine and nomifensine showed approximately the same inhibitory potency against this uptake as against 5ht uptake in platelets . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
4,
19
]
} | {
"id": "C0009010",
"name": "clomipramine",
"pos": [
33,
45
]
} |
the antidepressants imipramine , clomipramine , desipramine and nomifensine showed approximately the same inhibitory potency against this uptake as against 5ht uptake in platelets . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
4,
19
]
} | {
"id": "C0011685",
"name": "desipramine",
"pos": [
48,
59
]
} |
the anthelmintic efficacy of albendazole was evaluated as an oral drench at dosages of 15.0 , 10.0 , and 7.5 mg/kg of body weight in 3 groups crossbred brahman calves ( n = 12 group ) infected with fasciola hepatica . | therapeutic_class_of | {
"id": "C0003158",
"name": "anthelmintic",
"pos": [
4,
16
]
} | {
"id": "C0001911",
"name": "albendazole",
"pos": [
29,
40
]
} |
serial blood samples were obtained from 12 healthy adult dogs given equivalent subcutaneous and oral doses of the antibacterial combination , trimethoprim-sulfadiazine ( 1:5 ) . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
114,
127
]
} | {
"id": "C0041041",
"name": "trimethoprim",
"pos": [
142,
154
]
} |
serial blood samples were obtained from 12 healthy adult dogs given equivalent subcutaneous and oral doses of the antibacterial combination , trimethoprim-sulfadiazine ( 1:5 ) . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
114,
127
]
} | {
"id": "C0038675",
"name": "sulfadiazine",
"pos": [
155,
167
]
} |
a combination of antimalarials is necessary in order to effect a radical cure in chloroquine resistant falciparum malaria . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarials",
"pos": [
17,
30
]
} | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
81,
92
]
} |
the antibacterial activity of n-formimidoyl thienamycin was compared with those of cefotaxime , cefoperazone , and piperacillin against 536 clinical aerobic isolates . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
83,
93
]
} |
the antibacterial activity of n-formimidoyl thienamycin was compared with those of cefotaxime , cefoperazone , and piperacillin against 536 clinical aerobic isolates . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0007552",
"name": "cefoperazone",
"pos": [
96,
108
]
} |
the antibacterial activity of n-formimidoyl thienamycin was compared with those of cefotaxime , cefoperazone , and piperacillin against 536 clinical aerobic isolates . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0031955",
"name": "piperacillin",
"pos": [
115,
127
]
} |
the antibacterial activity of ftm-a against 50 gentamicin-susceptible and 50 gentamicin-resistant clinical isolates of p. aeruginosa was clearly enhanced by addition of a subinhibitory concentration of carbenicillin or piperacillin . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0006976",
"name": "carbenicillin",
"pos": [
202,
215
]
} |
the antibacterial activity of ftm-a against 50 gentamicin-susceptible and 50 gentamicin-resistant clinical isolates of p. aeruginosa was clearly enhanced by addition of a subinhibitory concentration of carbenicillin or piperacillin . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0031955",
"name": "piperacillin",
"pos": [
219,
231
]
} |
the in vitro activity of a new ora antimicrobial agent , mk-0366 ( am-715 ) , was compared with those of rosoxacin , ampicillin , erythromycin , and tetracycline against neisseria gonorrhoeae . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial agent",
"pos": [
35,
54
]
} | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
130,
142
]
} |
the in vitro activity of a new ora antimicrobial agent , mk-0366 ( am-715 ) , was compared with those of rosoxacin , ampicillin , erythromycin , and tetracycline against neisseria gonorrhoeae . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial agent",
"pos": [
35,
54
]
} | {
"id": "C0039644",
"name": "tetracycline",
"pos": [
149,
161
]
} |
the authors studied the antibacterial activity `` '' in vitro '' '' and `` '' in vivo '' '' of cefuroxime , cefamandole and cephalexin on the gram-positive and gram-negative bacterial strains of recent isolation . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
24,
37
]
} | {
"id": "C0007562",
"name": "cefuro",
"pos": [
95,
101
]
} |
the authors studied the antibacterial activity `` '' in vitro '' '' and `` '' in vivo '' '' of cefuroxime , cefamandole and cephalexin on the gram-positive and gram-negative bacterial strains of recent isolation . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
24,
37
]
} | {
"id": "C0007716",
"name": "and cephal",
"pos": [
120,
130
]
} |
the results showed a greater antibacterial activity of cefuroxime than the other two cephalosporins , mainly on the gram-negative beta-lactamase producing bacterial strains . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
29,
42
]
} | {
"id": "C0007562",
"name": "cefuroxime",
"pos": [
55,
65
]
} |
consequently both cefoperazone and moxalactam provided significantly better antibacterial effect in cerebrospinal fluid than did cefotaxime . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
76,
89
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
129,
139
]
} |
because of the frequent chronic use of antidepressants in treatment of depression , we investigated the in vivo effects of desmethylimipramine and lithium carbonate on sperm function in patients suffering from clinical depression . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
39,
54
]
} | {
"id": "C0011685",
"name": "desmethylimipramine",
"pos": [
123,
142
]
} |
antimalarial activity of mefloquine and chloroquine against blood induced plasmodium knowlesi infection in rhesus monkeys . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial",
"pos": [
0,
12
]
} | {
"id": "C0025153",
"name": "mefloquine",
"pos": [
25,
35
]
} |
antimalarial activity of mefloquine and chloroquine against blood induced plasmodium knowlesi infection in rhesus monkeys . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial",
"pos": [
0,
12
]
} | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
40,
51
]
} |
the in vitro antibacterial activity of cefoxitin was nearly equal to that of cez and cet against the 6 species of clinically isolated strains . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
13,
26
]
} | {
"id": "C0007557",
"name": "cefoxitin",
"pos": [
39,
48
]
} |
antibacterial activity : at a concentration of 3.13 mcg/ml , ctx inhibited the growth of 90.2 % of 92 strains of gram-negative rods and 80.0 % of 15 strains of gram-positive cocci . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
0,
13
]
} | {
"id": "C0007554",
"name": "ctx",
"pos": [
61,
64
]
} |
antibacterial activities of 6059-s against s. pyogenes , s. aureus , e. coli and p. aeruginosa , recently isolated from patients , 50 strains respectively was compared with that of cefazolin ( cez ) , cefmetazole ( cmz ) , ceftizoxime ( czx ) , cefotiam ( ctm ) and ticarcillin ( tipc ) . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
0,
13
]
} | {
"id": "C0007546",
"name": "cefazolin",
"pos": [
181,
190
]
} |
antibacterial activities of 6059-s against s. pyogenes , s. aureus , e. coli and p. aeruginosa , recently isolated from patients , 50 strains respectively was compared with that of cefazolin ( cez ) , cefmetazole ( cmz ) , ceftizoxime ( czx ) , cefotiam ( ctm ) and ticarcillin ( tipc ) . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
0,
13
]
} | {
"id": "C0007560",
"name": "ceftizoxime",
"pos": [
223,
234
]
} |
antibacterial activities of 6059-s against s. pyogenes , s. aureus , e. coli and p. aeruginosa , recently isolated from patients , 50 strains respectively was compared with that of cefazolin ( cez ) , cefmetazole ( cmz ) , ceftizoxime ( czx ) , cefotiam ( ctm ) and ticarcillin ( tipc ) . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
0,
13
]
} | {
"id": "C0040193",
"name": "ticarcillin",
"pos": [
266,
277
]
} |
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