text
stringlengths 57
1.72k
| relation
stringclasses 125
values | h
dict | t
dict |
|---|---|---|---|
the results of this study may suggest that women on antiepileptic treatment with phenytoin should be given an oral contraceptive with a comparatively high dose of the steroids to provide contraceptive efficacy . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic",
"pos": [
52,
65
]
} | {
"id": "C0031507",
"name": "phenytoin",
"pos": [
81,
90
]
} |
a comparison of the antiarrhythmic effects on av junctional re-entrant tachycardia of oral and intravenous flecainide acetate . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
20,
34
]
} | {
"id": "C0086303",
"name": "flecainide acetate",
"pos": [
107,
125
]
} |
antiarrhythmic actions of lorcainide were compared with those of disopyramide on different types of arrhythmias in animal models . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
0,
14
]
} | {
"id": "C0012702",
"name": "disopyramide",
"pos": [
65,
77
]
} |
a double-blind controlled trial comparing a standard antidepressant drug , amitriptyline , with a new compound , bupropion , was conducted at six centers . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant drug",
"pos": [
53,
72
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
75,
88
]
} |
the clinical efficacy and adverse reaction profile of bupropion , an atypical antidepressant , was compared with the tricyclic imipramine in 63 elderly depressives . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
78,
92
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
127,
137
]
} |
a double-blind multicenter evaluation compared the antidepressant efficacy of bupropion ( wellbutrin ) to both placebo and amitriptyline ( elavil , endep ) in adult patients who met dsm-iii criteria for major depressive disorder . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
51,
65
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
123,
136
]
} |
in a random assignment , double-blind , long-term follow-up study of 60 depressed in- and outpatients ( dsm-iii criteria ) in eight centers , the antidepressant actions of bupropion and amitriptyline were compared . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
146,
160
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
186,
199
]
} |
( ii ) other antiarrhythmic molecules like verapamil , amiodarone , bepridil , and f13004 which are noncompetitive inhibitors of [ 3h ] nitrendipine binding with dissociation constants between 0.2 and 1 microm . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
13,
27
]
} | {
"id": "C0002598",
"name": "amiodarone",
"pos": [
55,
65
]
} |
the antiarrhythmic action of lidocaine has been attributed solely to its direct electrophysiological effects on the heart . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
4,
18
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
29,
38
]
} |
we speculate that this effect is due to central nervous system effects of the drug and that this effect may contribute to the antiarrhythmic actions of lidocaine . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
126,
140
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
152,
161
]
} |
clots were incubated in human serum without drugs ( controls ) or with equimolar concentrations ( 2.5 to 20 nmol/ml ) of four antifungal antimicrobics : amb and miconazole ( both colloidal suspensions ) and dab and ket ( both molecularly dispersed ) . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
126,
136
]
} | {
"id": "C0002679",
"name": "amb",
"pos": [
153,
156
]
} |
clots were incubated in human serum without drugs ( controls ) or with equimolar concentrations ( 2.5 to 20 nmol/ml ) of four antifungal antimicrobics : amb and miconazole ( both colloidal suspensions ) and dab and ket ( both molecularly dispersed ) . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
126,
136
]
} | {
"id": "C0025942",
"name": "miconazole",
"pos": [
161,
171
]
} |
the neuropharmacological profile of a series of aminoalkylindole compounds ( ahr 1229- ( 3- [ 2- ( 3-indolyl ) -ethyl ] -butylamino-1-phenyl-pyrrolidine ) , ahr1771- ( 1- [ 2- ( 2-methyl-3-indolyl ) ethyl ] -4-phenyl-3,4-dehydropiperidine ) , ahr1806- ( 1- [ 2- ( 5-chloro-3-indolyl ) -ethyl ] -4-phenyl-3,4-dehydropiperidine ) , ahr1858- ( 1- [ 2- ( 3-indolyl ) ethyl ] -4- ( 4-fluorophenyl ) -1,2,3 , 6-tetrahydropyridine ) , ahr1709- ( 1- [ 2- ( 3-indolyl ) ethyl ] -4-phenyl-1,2,3,6-tetrahydropyridine ) was determined in comparison with the classical neuroleptic agents haloperidol and oxypertine , the latter being of similar indole structure . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic agents",
"pos": [
556,
574
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
575,
586
]
} |
a study of the antibacterial action of cefoperazone ( cpz ) and piperacillin ( pipc ) against e. coli demonstrated clear differences between these 2 drugs . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
15,
28
]
} | {
"id": "C0007552",
"name": "cefoperazone",
"pos": [
39,
51
]
} |
a study of the antibacterial action of cefoperazone ( cpz ) and piperacillin ( pipc ) against e. coli demonstrated clear differences between these 2 drugs . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
15,
28
]
} | {
"id": "C0031955",
"name": "piperacillin",
"pos": [
64,
76
]
} |
[ the antibacterial activity of new cephem antibiotics against clinical isolates . a comparison of the antibacterial activity of cefotaxime with 6 other antibiotics ] . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
6,
19
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
129,
139
]
} |
during the period from may through july 1981 , a comparative study was carried out on the antibacterial activities of cefotaxime ( ctx ) and ceftizoxime ( czx ) , cefoperazone ( cpz ) , latamoxef ( lmox ) , cefotiam ( ctm ) , cefmetazole ( cmz ) and cefazolin ( cez ) . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
90,
103
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
118,
128
]
} |
during the period from may through july 1981 , a comparative study was carried out on the antibacterial activities of cefotaxime ( ctx ) and ceftizoxime ( czx ) , cefoperazone ( cpz ) , latamoxef ( lmox ) , cefotiam ( ctm ) , cefmetazole ( cmz ) and cefazolin ( cez ) . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
90,
103
]
} | {
"id": "C0007560",
"name": "ceftizoxime",
"pos": [
141,
152
]
} |
during the period from may through july 1981 , a comparative study was carried out on the antibacterial activities of cefotaxime ( ctx ) and ceftizoxime ( czx ) , cefoperazone ( cpz ) , latamoxef ( lmox ) , cefotiam ( ctm ) , cefmetazole ( cmz ) and cefazolin ( cez ) . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
90,
103
]
} | {
"id": "C0007552",
"name": "cefoperazone",
"pos": [
163,
175
]
} |
during the period from may through july 1981 , a comparative study was carried out on the antibacterial activities of cefotaxime ( ctx ) and ceftizoxime ( czx ) , cefoperazone ( cpz ) , latamoxef ( lmox ) , cefotiam ( ctm ) , cefmetazole ( cmz ) and cefazolin ( cez ) . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
90,
103
]
} | {
"id": "C0007546",
"name": "cefazolin",
"pos": [
250,
259
]
} |
a high performance liquid chromatographic method is reported , which incorporates three internal standards ( i-cinchonidine , n-propylprocainamide , and para-chlorodisopyramide ) for the simultaneous quantitation of four commonly prescribed antiarrhythmic drugs : quinidine , procainamide , n-acetylprocainamide , and disopyramide . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drugs",
"pos": [
241,
261
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
264,
273
]
} |
a high performance liquid chromatographic method is reported , which incorporates three internal standards ( i-cinchonidine , n-propylprocainamide , and para-chlorodisopyramide ) for the simultaneous quantitation of four commonly prescribed antiarrhythmic drugs : quinidine , procainamide , n-acetylprocainamide , and disopyramide . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drugs",
"pos": [
241,
261
]
} | {
"id": "C0033216",
"name": "procainamide",
"pos": [
299,
311
]
} |
a high performance liquid chromatographic method is reported , which incorporates three internal standards ( i-cinchonidine , n-propylprocainamide , and para-chlorodisopyramide ) for the simultaneous quantitation of four commonly prescribed antiarrhythmic drugs : quinidine , procainamide , n-acetylprocainamide , and disopyramide . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drugs",
"pos": [
241,
261
]
} | {
"id": "C0012702",
"name": "disopyramide",
"pos": [
318,
330
]
} |
a 6-week double-blind comparison of mianserin , a new antidepressant , and amitriptyline allowed us to explore the problem of demonstrating main effect differences in drug/drug trials when the focus is primarily only upon efficacy or upon common adverse symptomatology . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
54,
68
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
75,
88
]
} |
thus , antidepressant drugs that have high affinity for [ 3h ] imipramine binding sites can exert an influence at the 5-ht cell body as well as at the 5-ht nerve terminal level . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant drugs",
"pos": [
7,
27
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
63,
73
]
} |
the present results underline the possibility that the 5-ht and dopamine hypotheses for the mechanism of action of antidepressant drugs are not mutually exclusive , because both 5-ht and dopamine neurons can be regulated by large numbers of [ 3h ] imipramine binding sites . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
115,
129
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
248,
258
]
} |
subchronic treatment of rats with the antidepressant drug chlorimipramine produced an accumulation of phospholipids ( pl ) which was particularly evident in lung and to a lesser extent in liver and spleen . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant drug",
"pos": [
38,
57
]
} | {
"id": "C0009010",
"name": "chlorimipramine",
"pos": [
58,
73
]
} |
ten patients with endogenous depression , who had not taken any antidepressive drugs for 3 months , were treated with 100 mg b.i.d . zimelidine ( five patients ) or 75 mg b.i.d . clomipramine ( five patients ) for 5-10 weeks . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressive",
"pos": [
64,
78
]
} | {
"id": "C0009010",
"name": "clomipramine",
"pos": [
179,
191
]
} |
the wide spectrum of antibacterial activity , the low toxicity , minimal tissue reaction , ease of application suggest that topical silver sulfadiazine therapy can safely be extended to other wound infections , wound covers and certain transplant materials . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
21,
34
]
} | {
"id": "C0037134",
"name": "silver sulfadiazine",
"pos": [
132,
151
]
} |
anti-malarial activity was observed in sera obtained from rabbits which received chloroquine , mefloquine , pyrimethamine and cycloguanil , but not in those which received 4-4 ' diacetyldiaminodiphenylsulphone ( dadds ) . | therapeutic_class_of | {
"id": "C0003374",
"name": "anti-malarial",
"pos": [
0,
13
]
} | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
81,
92
]
} |
anti-malarial activity was observed in sera obtained from rabbits which received chloroquine , mefloquine , pyrimethamine and cycloguanil , but not in those which received 4-4 ' diacetyldiaminodiphenylsulphone ( dadds ) . | therapeutic_class_of | {
"id": "C0003374",
"name": "anti-malarial",
"pos": [
0,
13
]
} | {
"id": "C0025153",
"name": "mefloquine",
"pos": [
95,
105
]
} |
classical neuroleptics such as haloperidol and chlorpromazine have no selectivity in the inhibition of d1 and d2 binding , whereas a number of 2-methoxy benzamide derivatives which have been synthesized in our laboratories exhibit rather different selectivity . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
10,
22
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
31,
42
]
} |
the in vitro activities of cefmenoxime , cefotetan , and n-formimidoyl thienamycin were compared with those of other antimicrobial agents ( metronidazole , clindamycin , cefoxitin , and moxalactam ) against anaerobic bacteria . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial agents",
"pos": [
117,
137
]
} | {
"id": "C0025872",
"name": "metronidazole",
"pos": [
140,
153
]
} |
the influence of an antiarrhythmic drug , quinidine , on the physical state of membrane phospholipids was investigated using model membranes , liposomes . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drug",
"pos": [
20,
39
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
42,
51
]
} |
4 we conclude that fluvoxamine seems to have the same general antidepressant efficacy as imipramine . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
62,
76
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
89,
99
]
} |
1 we report the results of a comparative clinical trial of a new antidepressant drug fluvoxamine ( a specific re-uptake inhibitor of 5-hydroxytryptamine ( 5-ht ) ) with chlorimipramine . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
65,
79
]
} | {
"id": "C0009010",
"name": "chlorimipramine",
"pos": [
169,
184
]
} |
5 we conclude that fluvoxamine , given in a single daily dose of 150-250 mg , provides antidepressant efficacy similar to chlorimipramine . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
87,
101
]
} | {
"id": "C0009010",
"name": "chlorimipramine",
"pos": [
122,
137
]
} |
in eight patients , small doses of neuroleptics , e.g. , 3 mg per day of haloperidol , prevented the acute provocation of a psychotic state by mpa reuse . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
35,
47
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
73,
84
]
} |
the antifungal polyene amphotericin b ( amb ) and its methyl ester derivative ( ame ) both show potent murine immunostimulant as well as b-cell activating effects . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
4,
14
]
} | {
"id": "C0002679",
"name": "amphotericin b",
"pos": [
23,
37
]
} |
studies in animal models and in the clinic have shown that it is highly active as a blood schizontocide against strains that are resistant to many established antimalarials , e.g. , chloroquine and pyrimethamine . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarials",
"pos": [
159,
172
]
} | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
182,
193
]
} |
these results suggest that the prefrontal cortex may be a possible site for the antipsychotic action of haloperidol . | therapeutic_class_of | {
"id": "C0040615",
"name": "antipsychotic",
"pos": [
80,
93
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
104,
115
]
} |
chronic treatment with the clinically effective antidepressants amitriptyline , imipramine , desmethylimipramine , iprindole , and trazodone produced an enhanced responsiveness to 5-meodmt . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
48,
63
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
64,
77
]
} |
chronic treatment with the clinically effective antidepressants amitriptyline , imipramine , desmethylimipramine , iprindole , and trazodone produced an enhanced responsiveness to 5-meodmt . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
48,
63
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
102,
112
]
} |
chronic treatment with the clinically effective antidepressants amitriptyline , imipramine , desmethylimipramine , iprindole , and trazodone produced an enhanced responsiveness to 5-meodmt . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
48,
63
]
} | {
"id": "C0011685",
"name": "desmethylimipramine",
"pos": [
93,
112
]
} |
chronic treatment with the neuroleptic haloperidol did not result in altered responsivity to the serotonin agonist . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
27,
38
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
39,
50
]
} |
five groups of drugs are reviewed : 1 ) antiarrhythmic drugs , including studies of phenytoin , tocainide , mexiletine and aprindine . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drugs",
"pos": [
40,
60
]
} | {
"id": "C0025887",
"name": "mexiletine",
"pos": [
108,
118
]
} |
the neuroleptic drug pimozide was administered chronically to rats at different doses ( 0.75 , 1.5 or 3.0 mg/kg , twice daily for 10 days ) or for different durations ( 1.5 mg/kg twice daily for 5 , 10 , 20 or 40 days ) . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic drug",
"pos": [
4,
20
]
} | {
"id": "C0031935",
"name": "pimozide",
"pos": [
21,
29
]
} |
ineffective local antidotes included sodium cromolyn , n-acetylcysteine , hydrocortisone , and heat ( which appeared to increase toxicity ) . | therapeutic_class_of | {
"id": "C0003295",
"name": "antidotes",
"pos": [
18,
27
]
} | {
"id": "C0001047",
"name": "n-acetylcysteine",
"pos": [
55,
71
]
} |
antirheumatic drugs , such as d-penicillamine , levamisole , gold salts , thiopronine and captopril , are potential aliphatic thiols with strong reducing properties . | therapeutic_class_of | {
"id": "C0003191",
"name": "antirheumatic drugs",
"pos": [
0,
19
]
} | {
"id": "C0030817",
"name": "penicillamine",
"pos": [
32,
45
]
} |
antibacterial activity of ctx is found to be superior to that of cez and equal to that of cmz against gram-positive bacteria ( s. aureus and s. epidermidis ) . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
0,
13
]
} | {
"id": "C0007554",
"name": "ctx",
"pos": [
26,
29
]
} |
antibacterial activity of ctx is found to be superior to that of cez and equal to that of cmz against gram-positive bacteria ( s. aureus and s. epidermidis ) . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
0,
13
]
} | {
"id": "C0007546",
"name": "cez",
"pos": [
65,
68
]
} |
the antibacterial activity of ctx against anaerobic bacteria exceeds that of cez and almost equal to that of cmz . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0007554",
"name": "ctx",
"pos": [
30,
33
]
} |
the antibacterial activity of ctx against anaerobic bacteria exceeds that of cez and almost equal to that of cmz . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0007546",
"name": "cez",
"pos": [
77,
80
]
} |
the antiepileptic drug phenytoin , administered in drinking water for 104 days , was used to reduce the neural overactivity ( pseudomyotonia ) of c57bl/6j dystrophic ( dy2j/dy2j ) male mice in an attempt to improve their breeding success over a 90-day period . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drug",
"pos": [
4,
22
]
} | {
"id": "C0031507",
"name": "phenytoin",
"pos": [
23,
32
]
} |
14co2 exhalation from [ n-methyl-14c ] benzphetamine was increased by pretreatment with the antidepressants as well as with phenobarbital , but imipramine had no influence on the exhalation of the label from [ 6-methoxy-14c ] - or [ 7-methoxy-14c ] -scoparone . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
92,
107
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
144,
154
]
} |
in a controlled 3 week trial on 20 endogenous depressive inpatients refractory to outpatient treatment and treated with two different types of antidepressive medication ( chlorimipramine vs. chlorimipramine combined with haloperidol in the first six days ) , the clonidine test was performed repetitiously to analyse changes of the functional state of central noradrenergic synapses . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressive",
"pos": [
143,
157
]
} | {
"id": "C0009010",
"name": "chlorimipramine",
"pos": [
191,
206
]
} |
in the rat , the acute administration of the neuroleptic drug , haloperidol , produces a parallel increase in brain and plasma concentrations of the dopamine metabolite , homovanillic acid ( hva ) . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
45,
56
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
64,
75
]
} |
in hypox rats , estradiol given during withdrawal from haloperidol decreased the characteristic increase in dopamine receptor density observed upon withdrawal from this neuroleptic , while the estrogen was ineffective when given concomitantly with haloperidol . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
169,
180
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
248,
259
]
} |
behavioral hypersensitivity in the rat consisting of increased dopamine-mediated stereotypic behaviors has been found to follow a 10-day course of treatment with the neuroleptic haloperidol as well as with the direct dopamine agonist apomorphine . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
166,
177
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
178,
189
]
} |
the acutely administered neuroleptics ( hal , cpz , clz ) produced dose-related decreases in time on task and number of reinforcers , but did not significantly affect variance of in-band force . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
25,
37
]
} | {
"id": "C0018546",
"name": "hal",
"pos": [
40,
43
]
} |
we tested clinical samples from patients receiving four commonly monitored antidepressant drugs -- amitriptyline , nortriptyline , imipramine , and desipramine -- to evaluate the reliability of currently available becton-dickinson vacutainer brand vacuum blood collection tubes . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant drugs",
"pos": [
75,
95
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
99,
112
]
} |
we tested clinical samples from patients receiving four commonly monitored antidepressant drugs -- amitriptyline , nortriptyline , imipramine , and desipramine -- to evaluate the reliability of currently available becton-dickinson vacutainer brand vacuum blood collection tubes . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant drugs",
"pos": [
75,
95
]
} | {
"id": "C0028420",
"name": "nortriptyline",
"pos": [
115,
128
]
} |
we tested clinical samples from patients receiving four commonly monitored antidepressant drugs -- amitriptyline , nortriptyline , imipramine , and desipramine -- to evaluate the reliability of currently available becton-dickinson vacutainer brand vacuum blood collection tubes . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant drugs",
"pos": [
75,
95
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
131,
141
]
} |
we tested clinical samples from patients receiving four commonly monitored antidepressant drugs -- amitriptyline , nortriptyline , imipramine , and desipramine -- to evaluate the reliability of currently available becton-dickinson vacutainer brand vacuum blood collection tubes . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant drugs",
"pos": [
75,
95
]
} | {
"id": "C0011685",
"name": "desipramine",
"pos": [
148,
159
]
} |
we present a fully automated high-pressure liquid chromatographic ( hplc ) assay for simultaneous quantitation of five antiepileptic drugs [ ethosuximide ( es ) , primidone , phenobarbital , phenytoin , and carbamazepine ] and their major metabolites [ phenylethylmalondiamide ( pema ) , carbamazepine-10,11-dihydro-10,11-diol ( cbzd ) , and carbamazepine-10,11-epoxide ( cbze ) ] in serum samples without sample pretreatment . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drugs",
"pos": [
119,
138
]
} | {
"id": "C0015043",
"name": "ethosuximide",
"pos": [
141,
153
]
} |
we present a fully automated high-pressure liquid chromatographic ( hplc ) assay for simultaneous quantitation of five antiepileptic drugs [ ethosuximide ( es ) , primidone , phenobarbital , phenytoin , and carbamazepine ] and their major metabolites [ phenylethylmalondiamide ( pema ) , carbamazepine-10,11-dihydro-10,11-diol ( cbzd ) , and carbamazepine-10,11-epoxide ( cbze ) ] in serum samples without sample pretreatment . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drugs",
"pos": [
119,
138
]
} | {
"id": "C0033148",
"name": "primidone",
"pos": [
163,
172
]
} |
we present a fully automated high-pressure liquid chromatographic ( hplc ) assay for simultaneous quantitation of five antiepileptic drugs [ ethosuximide ( es ) , primidone , phenobarbital , phenytoin , and carbamazepine ] and their major metabolites [ phenylethylmalondiamide ( pema ) , carbamazepine-10,11-dihydro-10,11-diol ( cbzd ) , and carbamazepine-10,11-epoxide ( cbze ) ] in serum samples without sample pretreatment . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drugs",
"pos": [
119,
138
]
} | {
"id": "C0031507",
"name": "phenytoin",
"pos": [
191,
200
]
} |
the in vitro antibacterial activity of ceftizoxime ( cefizox ) is influenced by the ambient ph of the medium . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
13,
26
]
} | {
"id": "C0007560",
"name": "ceftizoxime",
"pos": [
39,
50
]
} |
in patients with myocardial insufficiency and/or reduced hepatic metabolism antiarrhythmic therapy with lidocaine has to be performed with significantly reduced dosages ; | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
76,
90
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
104,
113
]
} |
the in vitro and in vivo antibacterial activities of mt-141 were compared with those of cefoxitin , cefmetazole , moxalactam , cefotaxime , and cefoperazone . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
25,
38
]
} | {
"id": "C0007557",
"name": "cefoxitin",
"pos": [
88,
97
]
} |
the in vitro and in vivo antibacterial activities of mt-141 were compared with those of cefoxitin , cefmetazole , moxalactam , cefotaxime , and cefoperazone . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
25,
38
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
127,
137
]
} |
the in vitro and in vivo antibacterial activities of mt-141 were compared with those of cefoxitin , cefmetazole , moxalactam , cefotaxime , and cefoperazone . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
25,
38
]
} | {
"id": "C0007552",
"name": "cefoperazone",
"pos": [
144,
156
]
} |
no definite results were obtained with slow acting antirheumatic drugs ( d-penicillamine , levamisole , gold thiosulphate , chloroquine ) , since results varied considerably . | therapeutic_class_of | {
"id": "C0003191",
"name": "antirheumatic drugs",
"pos": [
51,
70
]
} | {
"id": "C0030817",
"name": "penicillamine",
"pos": [
75,
88
]
} |
finally , in the third part , we present the principal cases of hepatotoxicity caused by psychotropic drugs : antidepressants ( maois and tricyclics ) , neuroleptics ( phenothiazines , thioxanthenes , butyrophenones and benzamides ) and anxiolytics , to which we add the anticonvulsants ( phenytoin , phenacemide , oxazolidinediones , carbamazepine and valproic acid ) . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
110,
125
]
} | {
"id": "C0006949",
"name": "carbamazepine",
"pos": [
335,
348
]
} |
finally , in the third part , we present the principal cases of hepatotoxicity caused by psychotropic drugs : antidepressants ( maois and tricyclics ) , neuroleptics ( phenothiazines , thioxanthenes , butyrophenones and benzamides ) and anxiolytics , to which we add the anticonvulsants ( phenytoin , phenacemide , oxazolidinediones , carbamazepine and valproic acid ) . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
110,
125
]
} | {
"id": "C0042291",
"name": "valproic acid",
"pos": [
353,
366
]
} |
among the antidotes considered are naloxone , physostigmine , folate , prussian blue , n-acetylcysteine , cimetidine , subcutaneous magnesium salts , nicotinamide , and thioctic acid . | therapeutic_class_of | {
"id": "C0003295",
"name": "antidotes",
"pos": [
10,
19
]
} | {
"id": "C0001047",
"name": "n-acetylcysteine",
"pos": [
87,
103
]
} |
the cataleptogenic neuroleptics haloperidol and metoclopramide reduce contralateral head turning in cats upon stimulation of the putamen and enhance these reactions from the caudate nucleus . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
19,
31
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
32,
43
]
} |
new antiarrhythmic drugs are chiefly assigned to class 1c and 1b : `` '' procainamide analogues '' '' ( acecainide , lorcainide , flecainide , encainide ) and propafenone for the former , and mexiletine , tocainide and aprindine for the latter . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drugs",
"pos": [
4,
24
]
} | {
"id": "C0016229",
"name": ", flecaini",
"pos": [
128,
138
]
} |
the influence on the platelets of a single large intravenous dose was also tested using eight antimicrobial drugs , viz . benzylpenicillin , ampicillin , carbenicillin , piperacillin , cloxacillin , cefuroxime , cefotaxime and erythromycin . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial drugs",
"pos": [
94,
113
]
} | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
227,
239
]
} |
ceftiolene ( 42980rp ) is a new cephalosporin with a broad antibacterial spectrum similar to cefotaxime or ceftriaxone . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
59,
72
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
93,
103
]
} |
ceftiolene ( 42980rp ) is a new cephalosporin with a broad antibacterial spectrum similar to cefotaxime or ceftriaxone . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
59,
72
]
} | {
"id": "C0007561",
"name": "ceftriaxone",
"pos": [
107,
118
]
} |
however , because of its powerful antibacterial activity and its high penetration into the cerebrospinal fluid , it seems reasonable to consider the use of a third generation cephalosporin , such as ceftriaxone , for the early treatment of meningitis in infants . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
34,
47
]
} | {
"id": "C0007561",
"name": "ceftriaxone",
"pos": [
199,
210
]
} |
a new antifungal triazole , itraconazole ( r51211 ) , was compared with ketoconazole in treatment of murine cryptococcosis . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
6,
16
]
} | {
"id": "C0022625",
"name": "ketoconazole",
"pos": [
72,
84
]
} |
the effect of the new antiarrhythmic drug flecainide was examined in a controlled long-term study ( 1 to 44 months [ x = 17.7 +/- 12.4 ] ) in 36 patients , aged 18 to 76 years ( x = 44 +/- 16.3 ) , suffering from ventricular arrhythmias . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
22,
36
]
} | {
"id": "C0016229",
"name": "flecainide",
"pos": [
42,
52
]
} |
comparative investigation of the antiarrhythmic effect of propafenone ( rytmonorm ) and lidocaine in patients with ventricular arrhythmias during acute myocardial infarction . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
33,
47
]
} | {
"id": "C0033429",
"name": "propafenone",
"pos": [
58,
69
]
} |
comparative investigation of the antiarrhythmic effect of propafenone ( rytmonorm ) and lidocaine in patients with ventricular arrhythmias during acute myocardial infarction . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
33,
47
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
88,
97
]
} |
studies in patients with vpds indicate that napa is also antiarrhythmic , although the contribution of napa to the antiarrhythmic effect after pa is not known . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
57,
71
]
} | {
"id": "C0033216",
"name": "pa",
"pos": [
143,
145
]
} |
2- ( 2-oxo-3-piperidyl ) -1,2-benzisothiazoline-3-one-1,1-dioxide ( supidimide ) , a functional synergist of neuroleptics in acute experiments , surprisingly antagonized the haloperidol-induced receptor augmentation , whereas other cns depressants ( diazepam and phenobarbital ) were ineffective . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
109,
121
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
174,
185
]
} |
the new antiarrhythmic drug propafenone and its main human metabolite 5-hydroxypropafenone were investigated for antiarrhythmic , local anaesthetic , ca++-antagonistic and beta-adrenoceptor blocking effects as well as for their activity on the central nervous system . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drug",
"pos": [
8,
27
]
} | {
"id": "C0033429",
"name": "propafenone",
"pos": [
79,
90
]
} |
the results show low cns activity of propafenone which is even lower for the metabolite but which is distinctly higher for lidocaine and - related to the antiarrhythmic potency - for flecainide , too . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
154,
168
]
} | {
"id": "C0016229",
"name": "flecainide",
"pos": [
183,
193
]
} |
[ the antibacterial activity in vitro of ofloxacin in comparison with other orally administered antimicrobial substances on ampicillin-resistant clinical isolates ] . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
6,
19
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
124,
134
]
} |
the antibacterial activity of ofloxacin ( dl 8280 , hoe 280 tarivid ) against ampicillin-resistant clinical isolates was compared to , penicillin v , tetracyclin-hcl , cefalexin , cefaclor , co-trimoxazole and nalidixic acid . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
78,
88
]
} |
the antibacterial activity of ofloxacin ( dl 8280 , hoe 280 tarivid ) against ampicillin-resistant clinical isolates was compared to , penicillin v , tetracyclin-hcl , cefalexin , cefaclor , co-trimoxazole and nalidixic acid . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0007716",
"name": "cefalexin",
"pos": [
168,
177
]
} |
the antibacterial activity of ofloxacin ( dl 8280 , hoe 280 tarivid ) against ampicillin-resistant clinical isolates was compared to , penicillin v , tetracyclin-hcl , cefalexin , cefaclor , co-trimoxazole and nalidixic acid . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0007537",
"name": "cefaclor",
"pos": [
180,
188
]
} |
forty-three of 67 antiarrhythmic regimens ( 64 % ) tested in the patients in whom ventricular tachycardia could not be induced after procainamide prevented induction of ventricular tachycardia , compared with 10 of 145 regimens ( 7 % ) tested in the patients in whom ventricular tachycardia could be induced after procainamide . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
18,
32
]
} | {
"id": "C0033216",
"name": "procainamide",
"pos": [
314,
326
]
} |
in 11 of 15 patients , antiarrhythmic drugs that had failed to suppress vt were continued during administration of amiodarone . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drugs",
"pos": [
23,
43
]
} | {
"id": "C0002598",
"name": "amiodarone",
"pos": [
115,
125
]
} |
in the 25 of 34 patients in whom the induction of vt was not suppressed by conventional antiarrhythmic drugs , 23 were treated with amiodarone ( daily dose 550 +/- 120 mg ) , and 2 underwent coronary artery bypass grafting with either aneurysmectomy or map-directed endocardial resection . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drugs",
"pos": [
88,
108
]
} | {
"id": "C0002598",
"name": "amiodarone",
"pos": [
132,
142
]
} |
during chronic therapy ( 24 +/- 3 months ) with quinidine either alone or in combination with a second antiarrhythmic drug in the 38 patients whose arrhythmia had been suppressed during electrophysiologic testing , 32 ( 84 % ) remain symptom-free while 3 have had recurrent arrhythmia and 3 discontinued quinidine because of adverse effects . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drug",
"pos": [
103,
122
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
304,
313
]
} |
determination of the antidepressants maprotiline and amoxapine , and their metabolites , in plasma by liquid chromatography . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
21,
36
]
} | {
"id": "C0002644",
"name": "amoxapine",
"pos": [
53,
62
]
} |
in adult tottering mice , the antiepileptic effects of a single dose of ethosuximide , diazepam , phenobarbital , or phenytoin were assessed using continuous electrocorticographic recording to monitor seizure incidence . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic",
"pos": [
30,
43
]
} | {
"id": "C0031507",
"name": "phenytoin",
"pos": [
117,
126
]
} |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.