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the antifungal activity of econazole nitrate ( pevaryl ) can be demonstrated by means of a new test -- called contact test -- developed by the authors . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
4,
14
]
} | {
"id": "C0546862",
"name": "econazole nitrate",
"pos": [
27,
44
]
} |
ten of 11 patients who had more than 10 vpds/hour had 90 % or greater arrhythmia suppression during antidepressant treatment with imipramine at plasma concentrations ranging from 100 -- 302 ng/ml . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
100,
114
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
130,
140
]
} |
we report here a patient who on two occasions developed clinically significant hyponatremia while receiving the antipsychotic drug , haloperidol . | therapeutic_class_of | {
"id": "C0040615",
"name": "antipsychotic drug",
"pos": [
112,
130
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
133,
144
]
} |
secondary aminated antidepressants ( desipramine and nortriptyline ) were more potent inhibitors than their tertiary aminated analogues ( imipramine , chlorimipramine and amitriptyline ) . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
19,
34
]
} | {
"id": "C0011685",
"name": "desipramine",
"pos": [
37,
48
]
} |
secondary aminated antidepressants ( desipramine and nortriptyline ) were more potent inhibitors than their tertiary aminated analogues ( imipramine , chlorimipramine and amitriptyline ) . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
19,
34
]
} | {
"id": "C0028420",
"name": "nortriptyline",
"pos": [
53,
66
]
} |
secondary aminated antidepressants ( desipramine and nortriptyline ) were more potent inhibitors than their tertiary aminated analogues ( imipramine , chlorimipramine and amitriptyline ) . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
19,
34
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
156,
166
]
} |
secondary aminated antidepressants ( desipramine and nortriptyline ) were more potent inhibitors than their tertiary aminated analogues ( imipramine , chlorimipramine and amitriptyline ) . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
19,
34
]
} | {
"id": "C0009010",
"name": "chlorimipramine",
"pos": [
151,
166
]
} |
secondary aminated antidepressants ( desipramine and nortriptyline ) were more potent inhibitors than their tertiary aminated analogues ( imipramine , chlorimipramine and amitriptyline ) . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
19,
34
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
171,
184
]
} |
we established a competitive nephelometric immunoassay method for the determination of the widely used antiepileptic drugs , phenobarbital and diphenylhydantoin , in human blood plasma . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drugs",
"pos": [
103,
122
]
} | {
"id": "C0031507",
"name": "diphenylhydantoin",
"pos": [
143,
160
]
} |
the antiarrhythmic activities of 6'-hydroxycinchonine and quinidine were compared following the infusion of aconitine into the tail veins of mice to induce arrhythmias . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
4,
18
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
58,
67
]
} |
these last compounds had potencies and ld50/ed50 ratios comparable to those of a standard antiarrhythmic , disopyramide . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
90,
104
]
} | {
"id": "C0012702",
"name": "disopyramide",
"pos": [
107,
119
]
} |
antibacterial activity of ticarcillin was determined in comparison with that of sulbenicillin , amoxicillin , cefuroxime , clindamycin and metronidazole against anaerobic bacteria which have been isolated from various clinical materials in this hospital . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
0,
13
]
} | {
"id": "C0040193",
"name": "ticarcillin",
"pos": [
26,
37
]
} |
antibacterial activity of ticarcillin was determined in comparison with that of sulbenicillin , amoxicillin , cefuroxime , clindamycin and metronidazole against anaerobic bacteria which have been isolated from various clinical materials in this hospital . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
0,
13
]
} | {
"id": "C0002645",
"name": "amoxicillin",
"pos": [
96,
107
]
} |
antibacterial activity of ticarcillin was determined in comparison with that of sulbenicillin , amoxicillin , cefuroxime , clindamycin and metronidazole against anaerobic bacteria which have been isolated from various clinical materials in this hospital . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
0,
13
]
} | {
"id": "C0007562",
"name": "cefuroxime",
"pos": [
110,
120
]
} |
antibacterial activity of ticarcillin was determined in comparison with that of sulbenicillin , amoxicillin , cefuroxime , clindamycin and metronidazole against anaerobic bacteria which have been isolated from various clinical materials in this hospital . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
0,
13
]
} | {
"id": "C0008947",
"name": "clindamycin",
"pos": [
123,
134
]
} |
antibacterial activity of ticarcillin against gram-positive anaerobic bacteria was found almost equal to sulbenicillin but slightly inferior to amoxicillin . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
0,
13
]
} | {
"id": "C0040193",
"name": "ticarcillin",
"pos": [
26,
37
]
} |
antibacterial activity of ticarcillin against gram-positive anaerobic bacteria was found almost equal to sulbenicillin but slightly inferior to amoxicillin . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
0,
13
]
} | {
"id": "C0002645",
"name": "amoxicillin",
"pos": [
144,
155
]
} |
[ comparison of antibacterial activity of mecillinam against recently isolated bacilli of 5 genera of enterobacteriaceae from clinical materials with ampicillin , amoxicillin , cephalexin , nalidixic acid and pipemidic acid ( author 's transl ) ] . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
16,
29
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
150,
160
]
} |
[ comparison of antibacterial activity of mecillinam against recently isolated bacilli of 5 genera of enterobacteriaceae from clinical materials with ampicillin , amoxicillin , cephalexin , nalidixic acid and pipemidic acid ( author 's transl ) ] . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
16,
29
]
} | {
"id": "C0002645",
"name": "amoxicillin",
"pos": [
163,
174
]
} |
[ comparison of antibacterial activity of mecillinam against recently isolated bacilli of 5 genera of enterobacteriaceae from clinical materials with ampicillin , amoxicillin , cephalexin , nalidixic acid and pipemidic acid ( author 's transl ) ] . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
16,
29
]
} | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
177,
187
]
} |
an exceptional position is held by cefotaxim with its generally outstanding antibacterial potency , and by cefoxitin with its activity against bacteroides fragilis . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
76,
89
]
} | {
"id": "C0007557",
"name": "cefoxitin",
"pos": [
107,
116
]
} |
mutagenicity evaluation of the two antimalarial agents chloroquine and mefloquine , using a bacterial fluctuation test . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial agents",
"pos": [
35,
54
]
} | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
55,
66
]
} |
mutagenicity evaluation of the two antimalarial agents chloroquine and mefloquine , using a bacterial fluctuation test . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial agents",
"pos": [
35,
54
]
} | {
"id": "C0025153",
"name": "mefloquine",
"pos": [
71,
81
]
} |
the two antimalarial agents chloroquine and mefloquine have been tested for mutagenicity in salmonella typhimurium strains ta1535 , ta1537 and ta1538 . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial agents",
"pos": [
8,
27
]
} | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
28,
39
]
} |
the two antimalarial agents chloroquine and mefloquine have been tested for mutagenicity in salmonella typhimurium strains ta1535 , ta1537 and ta1538 . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial agents",
"pos": [
8,
27
]
} | {
"id": "C0025153",
"name": "mefloquine",
"pos": [
44,
54
]
} |
we evaluated noradrenaline ( na ) level and na disappearance after fla-63 in some regions of the brain of rats chronically treated with antidepressants : imipramine ( imi ) , amitriptyline ( ami ) and danitracen ( dan ) . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
136,
151
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
154,
164
]
} |
we evaluated noradrenaline ( na ) level and na disappearance after fla-63 in some regions of the brain of rats chronically treated with antidepressants : imipramine ( imi ) , amitriptyline ( ami ) and danitracen ( dan ) . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
136,
151
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
175,
188
]
} |
the antidepressive effect of viloxazine ( 300 mg/d ) was investigated during three weeks in 41 patients with depressive syndromes requiring drug-treatment against amitriptyline ( 150 mg/d ) , using a controlled double-blind design . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressive",
"pos": [
4,
18
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
163,
176
]
} |
the antidepressants trimipramine and imipramine were compared within the framework of a multiclinical study performed under the conditions of a controlled clinical experiment . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
4,
19
]
} | {
"id": "C0041056",
"name": "trimipramine",
"pos": [
20,
32
]
} |
the antidepressants trimipramine and imipramine were compared within the framework of a multiclinical study performed under the conditions of a controlled clinical experiment . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
4,
19
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
37,
47
]
} |
the relative role of dopamine and norepinephrine receptor blockade in the action of antipsychotic drugs : metoclopramide , thiethylperazine , and molindone as pharmacological tools . | therapeutic_class_of | {
"id": "C0040615",
"name": "antipsychotic",
"pos": [
84,
97
]
} | {
"id": "C0026388",
"name": "molindone",
"pos": [
146,
155
]
} |
the antiarrhythmic effects of dl'propranolol , d-propranolol , metoprolol and lidocaine against ouabain-induced cardiac arrhythmias were studied . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
4,
18
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
78,
87
]
} |
the muscarinomimetics physostigmine and oxotremorine as well as the neuroleptics clozapine and haloperidol inhibited the climbing produced by ap 1 mg/kg . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
68,
80
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
95,
106
]
} |
the antiarrhythmic efficacy and tolerability of encainide and quinidine were compared in an open-design study in which 50 patients with recurrent supraventricular tachyarrhythmias received intravenous encainide in an initial phase and oral encainide and quinidine in a subsequent , randomized crossover phase . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
4,
18
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
254,
263
]
} |
based on antiarrhythmic efficacy , encainide is at least as effective as quinidine in the treatment of patients with supraventricular tachyarrhythmias . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
9,
23
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
73,
82
]
} |
using an in vitro system we measured the corneal epithelial cytotoxicity and the antiviral activity of the antiviral agents idoxuridine ( idu ) , trifluridine ( tft ) , ethyldeoxyuridine ( edu ) , and ( e ) -5- ( 2-bromovinyl ) -2'-deoxyuridine ( bvdu ) . | therapeutic_class_of | {
"id": "C0003451",
"name": "antiviral",
"pos": [
81,
90
]
} | {
"id": "C0040987",
"name": "trifluridine",
"pos": [
146,
158
]
} |
a broth microdilution method was used to examine the sensitivity of 75 haemophilus paragallinarum isolates to six antimicrobial drugs ( ampicillin , erythromycin , neomycin , penicillin , streptomycin , and tetracycline ) . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial drugs",
"pos": [
114,
133
]
} | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
149,
161
]
} |
a broth microdilution method was used to examine the sensitivity of 75 haemophilus paragallinarum isolates to six antimicrobial drugs ( ampicillin , erythromycin , neomycin , penicillin , streptomycin , and tetracycline ) . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial drugs",
"pos": [
114,
133
]
} | {
"id": "C0039644",
"name": "tetracycline",
"pos": [
207,
219
]
} |
rats were treated daily for 3 weeks with the antidepressant amitriptyline , and adaptations following this treatment at the level of the postsynaptic 5-ht2 receptor were studied , as well as the presynaptic serotonin re-uptake and the 5-ht autoreceptor functioning . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
45,
59
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
60,
73
]
} |
rabbits were treated chronically with one of the antidepressants amitriptyline , imipramine , chlorimipramine and mianserin , and the occurrence of the different pre- and postsynaptic adaptations were compared to what was observed in rat brain . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
49,
64
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
65,
78
]
} |
rabbits were treated chronically with one of the antidepressants amitriptyline , imipramine , chlorimipramine and mianserin , and the occurrence of the different pre- and postsynaptic adaptations were compared to what was observed in rat brain . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
49,
64
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
99,
109
]
} |
rabbits were treated chronically with one of the antidepressants amitriptyline , imipramine , chlorimipramine and mianserin , and the occurrence of the different pre- and postsynaptic adaptations were compared to what was observed in rat brain . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
49,
64
]
} | {
"id": "C0009010",
"name": "chlorimipramine",
"pos": [
94,
109
]
} |
there is an effective treatment available for this disabling condition -- a neuroleptic agent called pimozide , which appears to have a selective ability to block central dopaminergic receptors . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic agent",
"pos": [
76,
93
]
} | {
"id": "C0031935",
"name": "pimozide",
"pos": [
101,
109
]
} |
most cyclic antidepressants have a quinidinelike effect on the heart , which , in combination with type i antiarrhythmic agents such as quinidine , disopyramide and procainamide , may induce heart block and potentially lethal arrhythmias in susceptible individuals . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agents",
"pos": [
106,
127
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
136,
145
]
} |
most cyclic antidepressants have a quinidinelike effect on the heart , which , in combination with type i antiarrhythmic agents such as quinidine , disopyramide and procainamide , may induce heart block and potentially lethal arrhythmias in susceptible individuals . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agents",
"pos": [
106,
127
]
} | {
"id": "C0012702",
"name": "disopyramide",
"pos": [
148,
160
]
} |
most cyclic antidepressants have a quinidinelike effect on the heart , which , in combination with type i antiarrhythmic agents such as quinidine , disopyramide and procainamide , may induce heart block and potentially lethal arrhythmias in susceptible individuals . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agents",
"pos": [
106,
127
]
} | {
"id": "C0033216",
"name": "procainamide",
"pos": [
165,
177
]
} |
this difference in action against lymphocytes may help to explain the known disparity between the antifungal effects of fluconazole and ketoconazole against c. albicans in vivo and against experimental candida infections in vitro . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
98,
108
]
} | {
"id": "C0022625",
"name": "ketoconazole",
"pos": [
136,
148
]
} |
we previously reported a study on the antimicrobial action of a chemically synthesized drug , ofloxacin ( oflx ) and on its transfer in . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial",
"pos": [
38,
51
]
} | {
"id": "C0028902",
"name": "ofloxacin",
"pos": [
94,
103
]
} |
rats treated with two classic neuroleptic drugs at therapeutic doses , haloperidol ( 0.05 mg/kg/day i.p . ) and sulpiride ( 3 mg/kg/day i.p . ) showed a marked decline in cerebral levels of insulin ( 0.085 +/- 0.02 ng/g and 0.120 +/- 0.04 ng/g wet weight respectively ) compared to the control group ( 0.383 +/- 0.05 ng/g wet weight ) , while rats given d-amphetamine bitartrate chronically ( 20 mg/kg/day p.o . ) showed an increase in cerebral insulin ( 0.55 +/- 0.04 ng/g wet weight ) . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic drugs",
"pos": [
30,
47
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
71,
82
]
} |
all in all , the test substance cgp 12.103 a , the ( - ) or r-enantiomer of the antidepressant oxaprotiline , which itself is derived from maprotiline , showed no essential differences in its antidepressive efficacy compared with clomipramine . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressive",
"pos": [
192,
206
]
} | {
"id": "C0009010",
"name": "clomipramine",
"pos": [
230,
242
]
} |
the effect of chronic administration of the clinically effective antidepressants , imipramine , clomipramine and desipramine , on corticosterone ( cs ) release in male rats was investigated . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
65,
80
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
83,
93
]
} |
the effect of chronic administration of the clinically effective antidepressants , imipramine , clomipramine and desipramine , on corticosterone ( cs ) release in male rats was investigated . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
65,
80
]
} | {
"id": "C0009010",
"name": "clomipramine",
"pos": [
96,
108
]
} |
the effect of chronic administration of the clinically effective antidepressants , imipramine , clomipramine and desipramine , on corticosterone ( cs ) release in male rats was investigated . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
65,
80
]
} | {
"id": "C0011685",
"name": "desipramine",
"pos": [
113,
124
]
} |
mean ratings given to fluoxetine show a moderate antidepressant effect , equal to amitriptyline ( redomex , tryptizol 75 mg/d , clomipramine ( anafranil 75 mg/d and nialamide ( niamide 100 mg/d , weak psychostimulating and anxiolytic effects , a very weak sedative effect and a lack of anticholinergic and hypotensive effects . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
49,
63
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
82,
95
]
} |
mean ratings given to fluoxetine show a moderate antidepressant effect , equal to amitriptyline ( redomex , tryptizol 75 mg/d , clomipramine ( anafranil 75 mg/d and nialamide ( niamide 100 mg/d , weak psychostimulating and anxiolytic effects , a very weak sedative effect and a lack of anticholinergic and hypotensive effects . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
49,
63
]
} | {
"id": "C0009010",
"name": "clomipramine",
"pos": [
128,
140
]
} |
the pyridoindole derivative ( dh 1011 ) , a new antiarrhythmic agent , and quinidine were examined for teratogenic and embryotoxic activity in chick embryos . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agent",
"pos": [
48,
68
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
75,
84
]
} |
the following drug combinations additively augmented the antibacterial activity of 65 % ( v/v ) of human blood against two selected isolates of p. aeruginosa : tobramycin ( 1 microgram/ml ) plus the mic or 2 x mic concentrations of azlocillin , aztreonam , ceftazidime , ciprofloxacin , imipenem , norfloxacin , ofloxacin , piperacillin , and ticarcillin , respectively . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
57,
70
]
} | {
"id": "C0040341",
"name": "tobramycin",
"pos": [
160,
170
]
} |
the following drug combinations additively augmented the antibacterial activity of 65 % ( v/v ) of human blood against two selected isolates of p. aeruginosa : tobramycin ( 1 microgram/ml ) plus the mic or 2 x mic concentrations of azlocillin , aztreonam , ceftazidime , ciprofloxacin , imipenem , norfloxacin , ofloxacin , piperacillin , and ticarcillin , respectively . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
57,
70
]
} | {
"id": "C0004521",
"name": "aztreonam",
"pos": [
245,
254
]
} |
the following drug combinations additively augmented the antibacterial activity of 65 % ( v/v ) of human blood against two selected isolates of p. aeruginosa : tobramycin ( 1 microgram/ml ) plus the mic or 2 x mic concentrations of azlocillin , aztreonam , ceftazidime , ciprofloxacin , imipenem , norfloxacin , ofloxacin , piperacillin , and ticarcillin , respectively . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
57,
70
]
} | {
"id": "C0007559",
"name": "ceftazidime",
"pos": [
257,
268
]
} |
the following drug combinations additively augmented the antibacterial activity of 65 % ( v/v ) of human blood against two selected isolates of p. aeruginosa : tobramycin ( 1 microgram/ml ) plus the mic or 2 x mic concentrations of azlocillin , aztreonam , ceftazidime , ciprofloxacin , imipenem , norfloxacin , ofloxacin , piperacillin , and ticarcillin , respectively . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
57,
70
]
} | {
"id": "C0020933",
"name": "imipenem",
"pos": [
287,
295
]
} |
the following drug combinations additively augmented the antibacterial activity of 65 % ( v/v ) of human blood against two selected isolates of p. aeruginosa : tobramycin ( 1 microgram/ml ) plus the mic or 2 x mic concentrations of azlocillin , aztreonam , ceftazidime , ciprofloxacin , imipenem , norfloxacin , ofloxacin , piperacillin , and ticarcillin , respectively . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
57,
70
]
} | {
"id": "C0031955",
"name": "piperacillin",
"pos": [
324,
336
]
} |
the following drug combinations additively augmented the antibacterial activity of 65 % ( v/v ) of human blood against two selected isolates of p. aeruginosa : tobramycin ( 1 microgram/ml ) plus the mic or 2 x mic concentrations of azlocillin , aztreonam , ceftazidime , ciprofloxacin , imipenem , norfloxacin , ofloxacin , piperacillin , and ticarcillin , respectively . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
57,
70
]
} | {
"id": "C0040193",
"name": "ticarcillin",
"pos": [
343,
354
]
} |
monobactams ( ii a , f ) showed no significant in vitro antibacterial activity when compared with aztreonam and with some cephalosporins bearing the same e-hydrazono side chain . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
56,
69
]
} | {
"id": "C0004521",
"name": "aztreonam",
"pos": [
98,
107
]
} |
administration of the antifungal antibiotic amphotericin b ( amb , 1 mg/kg ) to intact rats produced acute lung injury as indicated by the extravascular leakage of protein and water and histological examination . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
22,
32
]
} | {
"id": "C0002679",
"name": "amb",
"pos": [
61,
64
]
} |
antifungal agents useful in the treatment of coccidioidomycosis are amphotericin b , which is administered intravenously and is relatively toxic , and ketoconazole , which is administered orally and whose toxicities are less serious and reversible . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal agents",
"pos": [
0,
17
]
} | {
"id": "C0002679",
"name": "amphotericin b",
"pos": [
68,
82
]
} |
antifungal agents useful in the treatment of coccidioidomycosis are amphotericin b , which is administered intravenously and is relatively toxic , and ketoconazole , which is administered orally and whose toxicities are less serious and reversible . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal agents",
"pos": [
0,
17
]
} | {
"id": "C0022625",
"name": "ketoconazole",
"pos": [
151,
163
]
} |
antibacterial activities of monobactam antibiotics ( carumonam ( crmn ) and aztreonam ( azt ] against gram-negative bacilli isolated from inpatients in the latter half of 1987 were investigated using penicillin ( pc : piperacillin ( pipc ] , cephems ( ceps : ceftazidime ( caz ) , cefotaxime ( ctx ) , latamoxef ( lmox ) , cefsulodin ( cfs ] , carbapenem ( imipenem ( ipm ] and pyridonecarboxylic acids ( norfloxacin ( nflx ) and ofloxacin ( oflx ] as reference antibiotics . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
0,
13
]
} | {
"id": "C0004521",
"name": "aztreonam",
"pos": [
76,
85
]
} |
antibacterial activities of monobactam antibiotics ( carumonam ( crmn ) and aztreonam ( azt ] against gram-negative bacilli isolated from inpatients in the latter half of 1987 were investigated using penicillin ( pc : piperacillin ( pipc ] , cephems ( ceps : ceftazidime ( caz ) , cefotaxime ( ctx ) , latamoxef ( lmox ) , cefsulodin ( cfs ] , carbapenem ( imipenem ( ipm ] and pyridonecarboxylic acids ( norfloxacin ( nflx ) and ofloxacin ( oflx ] as reference antibiotics . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
0,
13
]
} | {
"id": "C0031955",
"name": "piperacillin",
"pos": [
218,
230
]
} |
antibacterial activities of monobactam antibiotics ( carumonam ( crmn ) and aztreonam ( azt ] against gram-negative bacilli isolated from inpatients in the latter half of 1987 were investigated using penicillin ( pc : piperacillin ( pipc ] , cephems ( ceps : ceftazidime ( caz ) , cefotaxime ( ctx ) , latamoxef ( lmox ) , cefsulodin ( cfs ] , carbapenem ( imipenem ( ipm ] and pyridonecarboxylic acids ( norfloxacin ( nflx ) and ofloxacin ( oflx ] as reference antibiotics . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
0,
13
]
} | {
"id": "C0007559",
"name": "ceftazidime",
"pos": [
259,
270
]
} |
antibacterial activities of monobactam antibiotics ( carumonam ( crmn ) and aztreonam ( azt ] against gram-negative bacilli isolated from inpatients in the latter half of 1987 were investigated using penicillin ( pc : piperacillin ( pipc ] , cephems ( ceps : ceftazidime ( caz ) , cefotaxime ( ctx ) , latamoxef ( lmox ) , cefsulodin ( cfs ] , carbapenem ( imipenem ( ipm ] and pyridonecarboxylic acids ( norfloxacin ( nflx ) and ofloxacin ( oflx ] as reference antibiotics . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
0,
13
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
281,
291
]
} |
antibacterial activities of monobactam antibiotics ( carumonam ( crmn ) and aztreonam ( azt ] against gram-negative bacilli isolated from inpatients in the latter half of 1987 were investigated using penicillin ( pc : piperacillin ( pipc ] , cephems ( ceps : ceftazidime ( caz ) , cefotaxime ( ctx ) , latamoxef ( lmox ) , cefsulodin ( cfs ] , carbapenem ( imipenem ( ipm ] and pyridonecarboxylic acids ( norfloxacin ( nflx ) and ofloxacin ( oflx ] as reference antibiotics . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
0,
13
]
} | {
"id": "C0020933",
"name": "imipenem",
"pos": [
357,
365
]
} |
in vitro antibacterial activities of aztreonam ( azt ) and cephems against clinically isolated 334 strains were investigated . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
9,
22
]
} | {
"id": "C0004521",
"name": "aztreonam",
"pos": [
37,
46
]
} |
antibacterial activities of azt were superior against enterobacter cloacae , serratia marcescens and pseudomonas aeruginosa to those of cephems . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
0,
13
]
} | {
"id": "C0004521",
"name": "azt",
"pos": [
28,
31
]
} |
the antiparasitic agent ivermectin was administered to pregnant rats from days 6 to 20 of gestation and 2 to 20 of lactation at 1 , 2 or 4 mg/kg/day . | therapeutic_class_of | {
"id": "C0003404",
"name": "antiparasitic agent",
"pos": [
4,
23
]
} | {
"id": "C0022322",
"name": "ivermectin",
"pos": [
24,
34
]
} |
twenty patients aged 55 +/- 16 years with 40 chronic ventricular tachycardias ( vt ) refractory to 4.6 +/- 1.9 antiarrhythmic drugs , used alone or in combination , were managed by low doses of beta-blocker agents combined with oral amiodarone ( am ) , either after loading ( 1.2 g for 7 days , n : 5 ) or reloading ( 1.2 g for 4 days , n : 15 ) of am . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drugs",
"pos": [
111,
131
]
} | {
"id": "C0002598",
"name": "am",
"pos": [
349,
351
]
} |
we tested the effects of the conventional anxiolytics chlordiazepoxide ( 4-32 mg/kg ) and meprobamate ( 75-125 mg/kg ) , the novel anxiolytic buspirone ( 8-64 mg/kg ) , the antidepressant imipramine ( 4-16 mg/kg ) , the opiate analgesic morphine ( 2-8 mg/kg ) , and the antipsychotic chlorpromazine ( 1-16 mg/kg ) on cdb . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
173,
187
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
188,
198
]
} |
risperidone , a new antipsychotic agent , was studied for its effects on spontaneous motor activity in rats in comparison with haloperidol . | therapeutic_class_of | {
"id": "C0040615",
"name": "antipsychotic agent",
"pos": [
20,
39
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
127,
138
]
} |
in a randomized study , we analyzed the antiarrhythmic efficacy and tolerance of diprafenone ( 450-600 mg/day ) in comparison to that of propafenone ( 450-500 mg/day ) in ten patients with frequent and complex ventricular premature beats . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
40,
54
]
} | {
"id": "C0033429",
"name": "propafenone",
"pos": [
137,
148
]
} |
while the antiarrhythmic efficacy of lidocaine and other , newer class i-antiarrhythmic drugs is well established , the antifibrillatory effects of these drugs in the early phase of acute myocardial infarction remain uncertain . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
10,
24
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
37,
46
]
} |
an antifungal agent ( flucytosine ) was used to treat urinary candidiasis in 9 patients who had an indwelling catheter and developed fungal colony counts greater than 10 ( 4 ) . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal agent",
"pos": [
3,
19
]
} | {
"id": "C0016278",
"name": "flucytosine",
"pos": [
22,
33
]
} |
administration of 4 antipsychotic drugs , haloperidol , chlorpromazine , thioridazine and clozapine , for 21 days elicited increased dopamine metabolism in frontal cortex of rat brain . | therapeutic_class_of | {
"id": "C0040615",
"name": "antipsychotic",
"pos": [
20,
33
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
42,
53
]
} |
a prospective multicentre study was carried out to study intensive care requirements in patients undergoing elective surgery of the alimentary tract in hospitals using a standardized antimicrobial prophylaxis regimen of a single intravenous dose of 400 mg doxycycline plus 1600 mg tinidazole 1-hour pre-operatively or at induction of anaesthesia . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial",
"pos": [
183,
196
]
} | {
"id": "C0040263",
"name": "tinidazole",
"pos": [
281,
291
]
} |
a multi-factor analysis showed that risk factors are ( in decreasing order ) : female gender , age above 60 , associated depression , total duration of neuroleptic treatment above 20 years , a frequently discontinued treatment , shock therapies in antecedents or associated , a diagnosis of non schizophrenic psychosis , haloperidol intake below 25 mg and fluphenazine depot above 100 mg daily . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
152,
163
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
321,
332
]
} |
in a nordic multicenter study , various neuroleptics ( haloperidol , perphenazine , chlorprothixene ) were given to 33 elderly psychiatric patients with td . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
40,
52
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
55,
66
]
} |
the most active antimicrobial agents were aztreonam , cefixime , and the two quinolone derivatives ciprofloxacin and ofloxacin . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial agents",
"pos": [
16,
36
]
} | {
"id": "C0008809",
"name": "ciprofloxacin",
"pos": [
99,
112
]
} |
the most active antimicrobial agents were aztreonam , cefixime , and the two quinolone derivatives ciprofloxacin and ofloxacin . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial agents",
"pos": [
16,
36
]
} | {
"id": "C0028902",
"name": "ofloxacin",
"pos": [
117,
126
]
} |
clozapine , melperone and setoperone , three atypical neuroleptics , blocked in a dose-dependent manner , the hyperthermic response to the 5-ht agonist , mk-212 , whereas chlorpromazine and haloperidol were ineffective . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
54,
66
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
190,
201
]
} |
conversely , the typical neuroleptics , haloperidol and chlorpromazine do not block the 5-ht receptors involved in activation of the hypothalamic-pituitary-adrenal axis or thermoregulation . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
25,
37
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
40,
51
]
} |
long-term or short-term treatment with the mao type a inhibiting antidepressant , clorgyline , or tricyclic antidepressants ( imipramine and clomipramine ) , did not change baseline levels of either prolactin or corticosterone . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
65,
79
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
126,
136
]
} |
long-term or short-term treatment with the mao type a inhibiting antidepressant , clorgyline , or tricyclic antidepressants ( imipramine and clomipramine ) , did not change baseline levels of either prolactin or corticosterone . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
65,
79
]
} | {
"id": "C0009010",
"name": "clomipramine",
"pos": [
141,
153
]
} |
the pharmacokinetics and pharmacodynamics of the extensively metabolized antiarrhythmic agent propafenone were assessed alone and during concomitant administration of cimetidine . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agent",
"pos": [
73,
93
]
} | {
"id": "C0033429",
"name": "propafenone",
"pos": [
94,
105
]
} |
although both selective antagonists were studied at larger doses than those minimally effective , they produced slight eeg and behavioural changes which were not comparable with the marked actions produced by classical neuroleptics , such as haloperidol . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
219,
231
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
242,
253
]
} |
three topical antibiotics and four antiseptics ( 1 % povidone-iodine , 0.25 % acetic acid , 3 % hydrogen peroxide , and 0.5 % sodium hypochlorite ) were directly applied to cultured human fibroblasts to quantitatively assess their cytotoxicity . | therapeutic_class_of | {
"id": "C0003205",
"name": "antiseptics",
"pos": [
35,
46
]
} | {
"id": "C0032857",
"name": "povidone-iodine",
"pos": [
53,
68
]
} |
the effect of the antimalarial drug primaquine , its stereoisomers and its proposed metabolites , on the metabolism of substrates for mixed function oxidase , has been studied in isolated perfused rat livers ( iprl ) and/or in vitro microsomal suspension . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial",
"pos": [
18,
30
]
} | {
"id": "C0033126",
"name": "primaquine",
"pos": [
36,
46
]
} |
the effect of the new antimalarial drug mefloquine ( mq ) on hepatic drug metabolism in the rat has been studied in vitro and in vivo using three different substrates , aminopyrine , ethinyloestradiol and tolbutamide . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial",
"pos": [
22,
34
]
} | {
"id": "C0025153",
"name": "mefloquine",
"pos": [
40,
50
]
} |
a case of mania secondary to the administration of a new antiarrhythmic , propafenone , is described . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
57,
71
]
} | {
"id": "C0033429",
"name": "propafenone",
"pos": [
74,
85
]
} |
outpatients with major affective disorder , unipolar depressed type ( n=101 ) , were treated in a 4-week placebo-controlled double-blind study to compare the efficacy and safety of fluvoxamine , a new serotonin reuptake inhibitor antidepressant , with imipramine and placebo . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
230,
244
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
252,
262
]
} |
a comparative trial of the antidepressant , anxiolytic , and cardiovascular effects of trimipramine and doxepin in depressed hospitalized patients . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
27,
41
]
} | {
"id": "C0041056",
"name": "trimipramine",
"pos": [
87,
99
]
} |
a comparative trial of the antidepressant , anxiolytic , and cardiovascular effects of trimipramine and doxepin in depressed hospitalized patients . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
27,
41
]
} | {
"id": "C0013085",
"name": "doxepin",
"pos": [
104,
111
]
} |
forty-two outpatients with major depression were treated in a 4-week double-blind parallel-group comparison of the new antidepressant clovoxamine -- a member of oximethers of aralkylketones -- with amitriptyline . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
119,
133
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
198,
211
]
} |
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