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the butyrophenone neuroleptics spiroperidol , benperidol , and haloperidol were radiolabeled with fluorine-18 and studied in baboon brain using positron emission transaxial tomography ( pett ) . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
18,
30
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
63,
74
]
} |
drugs of different chemical structure and spectrum , but having in common the property of blocking da receptors and being effective neuroleptics such as haloperidol , sulpiride , and flupentixol , stimulated da release and dopac and hva output . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
132,
144
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
153,
164
]
} |
moreover , whereas da release did not increase by more than 100 % over basal values , dopac and hva increased by more than 3 times after maximally effective doses of neuroleptics . gamma-butyrolactone ( 200 mg/kg , i.p . ) reversed haloperidol ( 0.1 mg/kg , s.c. ) , and sulpiride ( 20 mg/kg , s.c. ) induced stimulation of da release while it potentiated the stimulation of dopac and hva output . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
166,
178
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
232,
243
]
} |
the antidote was found to inhibit covalent binding of acetaminophen by about 70 % when n-acetylcysteine protected against liver necrosis . | therapeutic_class_of | {
"id": "C0003295",
"name": "antidote",
"pos": [
4,
12
]
} | {
"id": "C0001047",
"name": "n-acetylcysteine",
"pos": [
87,
103
]
} |
the neuroleptic , pimozide , injected systemically four hours prior to morphine administration completely blocked the increased locomotor activity but had no effect on the hyperthermia . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
4,
15
]
} | {
"id": "C0031935",
"name": "pimozide",
"pos": [
18,
26
]
} |
these data indicate that successful antidepressant treatment may increase the density of 3h-imipramine binding sites on platelets by a process which is independent of the uptake of serotonin . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
36,
50
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
92,
102
]
} |
neuroleptic drugs attenuate calcium influx and tension development in rabbit thoracic aorta : effects of pimozide , penfluridol , chlorpromazine , and haloperidol . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic drugs",
"pos": [
0,
17
]
} | {
"id": "C0031935",
"name": "pimozide",
"pos": [
105,
113
]
} |
neuroleptic drugs attenuate calcium influx and tension development in rabbit thoracic aorta : effects of pimozide , penfluridol , chlorpromazine , and haloperidol . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic drugs",
"pos": [
0,
17
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
151,
162
]
} |
the effects of the neuroleptics alpha-flupentixol ( 0.8 mg/kg , ip ) and haloperidol ( 1.0 mg/kg , ip ) were tested against the place preferences produced by morphine sulphate ( 1.0 and 5.0 mg/kg , sc ) , d-amphetamine sulphate ( 1.0 mg/kg , ip ) and cocaine hydrochloride ( 5.0 mg/kg , ip ) . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
19,
31
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
73,
84
]
} |
anthelmintic trails , conducted with albendazole , fenbendazole and ivermectin for efficacy against gastrointestinal nematodes , principally inhibited early fourth larval stages of ostertagia ostertagi in naturally infected cattle . | therapeutic_class_of | {
"id": "C0003158",
"name": "anthelmintic",
"pos": [
0,
12
]
} | {
"id": "C0001911",
"name": "albendazole",
"pos": [
37,
48
]
} |
twenty-three patients ( group i ) were placed on long-term antiarrhythmic therapy ( 20 patients received procainamide and the remaining quinidine ) . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
59,
73
]
} | {
"id": "C0033216",
"name": "procainamide",
"pos": [
105,
117
]
} |
twenty-three patients ( group i ) were placed on long-term antiarrhythmic therapy ( 20 patients received procainamide and the remaining quinidine ) . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
59,
73
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
136,
145
]
} |
the antimicrobial regimens were metronidazole alone or metronidazole and ampicillin administered systemically preoperatively and continued for 3 days . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial",
"pos": [
4,
17
]
} | {
"id": "C0025872",
"name": "metronidazole",
"pos": [
55,
68
]
} |
it was observed that after application of antiarrhythmic drugs lidocaine or mexiletine there was a prominent growth of cycle length of reverberator during first few seconds of circulation and a little change of cycle length for the circus movement around obstacle . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drugs",
"pos": [
42,
62
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
63,
72
]
} |
it was observed that after application of antiarrhythmic drugs lidocaine or mexiletine there was a prominent growth of cycle length of reverberator during first few seconds of circulation and a little change of cycle length for the circus movement around obstacle . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drugs",
"pos": [
42,
62
]
} | {
"id": "C0025887",
"name": "mexiletine",
"pos": [
76,
86
]
} |
wide debridement , delayed wound closure , and vigorous antimicrobial therapy with streptomycin and tetracycline , along with cephalosporin for secondary staphylococcal infection , were necessary measures before the infection was eradicated . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial",
"pos": [
56,
69
]
} | {
"id": "C0039644",
"name": "tetracycline",
"pos": [
100,
112
]
} |
studies on the biotransformation in the perfused rat liver of 2-n-propyl-4-pentenoic acid , a metabolite of the antiepileptic drug valproic acid . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drug",
"pos": [
112,
130
]
} | {
"id": "C0042291",
"name": "valproic",
"pos": [
131,
139
]
} |
in vitro experiments have shown that the antiarrhythmic effects of propafenone are due to a direct depressant action and to a beta-blocking activity . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
41,
55
]
} | {
"id": "C0033429",
"name": "propafenone",
"pos": [
67,
78
]
} |
the so-called atypical neuroleptics show far less dopamine blocking potency in human striatum compared to haloperidol , with equal receptor blocking potency in the limbic system . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
23,
35
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
106,
117
]
} |
children ( n = 16 ) receiving multiple aed therapy had a higher clearance ( 23.5 vs 13.0 ml/hr/kg , p less than 0.001 ) , larger volume of distribution ( 0.30 vs 0.22 l/kg , p less than 0.01 ) , and shorter half-life ( 9.4 vs 12.3 hours , p less than 0.01 ) than did those ( n = 21 ) receiving vpa only . | therapeutic_class_of | {
"id": "C0003299",
"name": "aed",
"pos": [
39,
42
]
} | {
"id": "C0042291",
"name": "vpa",
"pos": [
294,
297
]
} |
the anthelmintic benzimidazoles , mebendazole , albendazole and flubendazole have been screened for any propensity to alter the disposition of antipyrine and tolbutamide in the rat isolated perfused liver preparation . | therapeutic_class_of | {
"id": "C0003158",
"name": "anthelmintic",
"pos": [
4,
16
]
} | {
"id": "C0025023",
"name": "mebendazole",
"pos": [
34,
45
]
} |
the anthelmintic benzimidazoles , mebendazole , albendazole and flubendazole have been screened for any propensity to alter the disposition of antipyrine and tolbutamide in the rat isolated perfused liver preparation . | therapeutic_class_of | {
"id": "C0003158",
"name": "anthelmintic",
"pos": [
4,
16
]
} | {
"id": "C0001911",
"name": "albendazole",
"pos": [
48,
59
]
} |
the effect of the antiepileptic drug valproic acid ( di-n-propylacetic acid , 200 mg kg-1 ) on brain 5-hydroxytryptamine ( 5-ht ) synthesis during monoamine oxidase inhibition by pargyline hydrochloride ( 120 mg kg-1 ) was studied in mice . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic",
"pos": [
18,
31
]
} | {
"id": "C0042291",
"name": "di-n-propylacetic acid",
"pos": [
53,
75
]
} |
this study was performed to investigate spontaneous variability in vpc frequency , to determine standards for distinguishing antiarrhythmic efficacy from the spontaneous variability , and to compare the effectiveness of disopyramide , mexiletine , aprindine , propranolol , and diltiazem . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
125,
139
]
} | {
"id": "C0012702",
"name": "disopyramide",
"pos": [
220,
232
]
} |
this study was performed to investigate spontaneous variability in vpc frequency , to determine standards for distinguishing antiarrhythmic efficacy from the spontaneous variability , and to compare the effectiveness of disopyramide , mexiletine , aprindine , propranolol , and diltiazem . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
125,
139
]
} | {
"id": "C0025887",
"name": "mexiletine",
"pos": [
235,
245
]
} |
therapeutic use of the potent antiarrhythmic drug amiodarone requires early detection of impending hyperthyroidism , a potentially life-threatening adverse reaction in cardiac patients . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
30,
44
]
} | {
"id": "C0002598",
"name": "amiodarone",
"pos": [
50,
60
]
} |
without affecting the antiarrhythmic properties of disopyramide , a sustained-release form of pyridostigmine ( a cholinesterase inhibitor ) was shown to prevent completely anticholinergic side effects in a study population ( 17 patients ) , whereas side effects occurred in 26 of 89 patients ( 29 % ) in a control group ( p less than 0.025 ) . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
22,
36
]
} | {
"id": "C0012702",
"name": "disopyramide",
"pos": [
51,
63
]
} |
comparative cardiac electrophysiologic study of pk 10139 , a new antiarrhythmic agent , and quinidine in anesthetized dogs : plasma concentration-response relationships . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
65,
79
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
92,
101
]
} |
cardiac electrophysiologic effects of pk 10139 ( pk ) , a new quinoleic antiarrhythmic agent , were compared with those of quinidine sulphate ( q ) after three cumulative intravenous doses of 0.75 , 1.5 , and 3 mg/kg of pk and 5 , 10 , and 20 mg/kg of q in anesthetized dogs . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agent",
"pos": [
72,
92
]
} | {
"id": "C0034415",
"name": "quinidine sulphate",
"pos": [
123,
141
]
} |
the gaba receptor agonist progabide has been shown to exert an antidepressant action which is indistinguishable from that of imipramine in patients with major affective disorders . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
63,
77
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
125,
135
]
} |
three boys 3.3 to 3.9 years old , who had precocious puberty that was unresponsive to an analogue of gonadotropin-releasing hormone , were treated with the antifungal agent ketoconazole for up to 12 months . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal agent",
"pos": [
156,
172
]
} | {
"id": "C0022625",
"name": "ketoconazole",
"pos": [
173,
185
]
} |
when a variety of neuroleptic drugs were tested , fluphenazine , chlorpromazine and haloperidol resulted in comparable reductions in beta-endorphin immunoreactivity in the striatum . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic drugs",
"pos": [
18,
35
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
84,
95
]
} |
a new antifungal agent , ketoconazole , has been added to the drugs available for the treatment of fungal infections . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal agent",
"pos": [
6,
22
]
} | {
"id": "C0022625",
"name": "ketoconazole",
"pos": [
25,
37
]
} |
the antiarrhythmic and antifibrillatory effects of flecainide acetate during the early postinfarction period were evaluated in a conscious canine model of sudden cardiac death . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
4,
18
]
} | {
"id": "C0086303",
"name": "flecainide acetate",
"pos": [
51,
69
]
} |
during 55 antiarrhythmic drug trials ( 24 of procainamide , 21 of quinidine , 10 of disopyramide ) in the 24 patients , 6 patients had a proarrhythmic response : sustained monomorphic ventricular tachycardia in 3 , ventricular fibrillation in 2 , nonsustained monomorphic ventricular tachycardia in 1 . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
10,
24
]
} | {
"id": "C0033216",
"name": "procainamide",
"pos": [
45,
57
]
} |
during 55 antiarrhythmic drug trials ( 24 of procainamide , 21 of quinidine , 10 of disopyramide ) in the 24 patients , 6 patients had a proarrhythmic response : sustained monomorphic ventricular tachycardia in 3 , ventricular fibrillation in 2 , nonsustained monomorphic ventricular tachycardia in 1 . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
10,
24
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
66,
75
]
} |
during 55 antiarrhythmic drug trials ( 24 of procainamide , 21 of quinidine , 10 of disopyramide ) in the 24 patients , 6 patients had a proarrhythmic response : sustained monomorphic ventricular tachycardia in 3 , ventricular fibrillation in 2 , nonsustained monomorphic ventricular tachycardia in 1 . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
10,
24
]
} | {
"id": "C0012702",
"name": "disopyramide",
"pos": [
84,
96
]
} |
the activities of sr 95191 were compared to those of the maois moclobemide , clorgyline , pargyline and l-deprenyl , as well as to those of the antidepressant drugs imipramine , nomifensine and indalpine and to those of the daergic drugs ( + ) -amphetamine and apomorphine . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant drugs",
"pos": [
144,
164
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
165,
175
]
} |
the present study demonstrates that the antiepileptic drug diphenylhydantoin ( dph ) is capable of inducing aneuploidy but not structural aberrations in cultured mouse embryonic fibroblasts . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drug",
"pos": [
40,
58
]
} | {
"id": "C0031507",
"name": "diphenylhydantoin",
"pos": [
59,
76
]
} |
the efficacies of antifungal prophylaxis with ketoconazole and itraconazole , a new triazole , in patients with prolonged granulocytopenia were evaluated in two nonrandomized studies . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
18,
28
]
} | {
"id": "C0022625",
"name": "ketoconazole",
"pos": [
46,
58
]
} |
liver damage induced by the antiepileptic drug valproic acid ( vpa ) is believed to be mediated by an unsaturated metabolite of the drug , delta 4-vpa . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drug",
"pos": [
28,
46
]
} | {
"id": "C0042291",
"name": "vpa",
"pos": [
147,
150
]
} |
this was probably the result of irritation of the peritoneal membrane caused by the antifungal treatment , possibly by amphotericin b . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
84,
94
]
} | {
"id": "C0002679",
"name": "amphotericin",
"pos": [
119,
131
]
} |
the ultrastructural changes induced by the administration of a recently developed antimalarial drug , mefloquine , were studied in mice infected with plasmodium berghei and human erythrocytes infected with p. falciparum in vitro . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial drug",
"pos": [
82,
99
]
} | {
"id": "C0025153",
"name": "mefloquine",
"pos": [
102,
112
]
} |
cellular levels comparable to those found during antirheumatic therapy were achieved by preincubation for 60 minutes with up to 0.1 mm chloroquine or hydroxychloroquine . | therapeutic_class_of | {
"id": "C0003191",
"name": "antirheumatic",
"pos": [
49,
62
]
} | {
"id": "C0020336",
"name": "hydroxychloroquine",
"pos": [
150,
168
]
} |
in the present study the elimination of the antimalarial primaquine has been examined in isolated perfused rat livers ( iprl ) of malaria-infected sprague-dawley rats ( 90-110 g ) ( mi group ; n = 6 ) and age- and weight-matched healthy rats ( control group ; n = 7 ) . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial",
"pos": [
44,
56
]
} | {
"id": "C0033126",
"name": "primaquine",
"pos": [
57,
67
]
} |
( 3 ) a washout of antidepressants of 4 weeks may be needed when studying the parameters of [ 3h ] imipramine binding in platelets from depressed patients if the previous medication involved chlorimipramine . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
19,
34
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
196,
206
]
} |
( 3 ) a washout of antidepressants of 4 weeks may be needed when studying the parameters of [ 3h ] imipramine binding in platelets from depressed patients if the previous medication involved chlorimipramine . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
19,
34
]
} | {
"id": "C0009010",
"name": "chlorimipramine",
"pos": [
191,
206
]
} |
treatment with various antimicrobials was followed by recovery , but the relapse rate was lowest with combined tetracycline and streptomycin . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobials",
"pos": [
23,
37
]
} | {
"id": "C0039644",
"name": "tetracycline",
"pos": [
111,
123
]
} |
[ experience with the therapy of symptomatic liver porphyria using a combination of antimalarial agents -- chloroquine with pyrimethamine ] . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial agents",
"pos": [
84,
103
]
} | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
107,
118
]
} |
use of antiarrhythmic medications other than lidocaine decreased consistently over time ( 31 % , 1975 ; 22 % , 1984 ) . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic medications",
"pos": [
7,
33
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
45,
54
]
} |
tolerability and antiarrhythmic efficacy of disopyramide compared to lignocaine in selected patients with suspected acute myocardial infarction . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
17,
31
]
} | {
"id": "C0012702",
"name": "disopyramide",
"pos": [
44,
56
]
} |
tolerability and antiarrhythmic efficacy of disopyramide compared to lignocaine in selected patients with suspected acute myocardial infarction . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
17,
31
]
} | {
"id": "C0023660",
"name": "lignocaine",
"pos": [
69,
79
]
} |
antibacterial antibiotics ( penicillin g , polymixin b , cephalosporin c and streptomycin ) greatly reduced ( p less than .05 ) ammonia formation from casein . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
0,
13
]
} | {
"id": "C0030827",
"name": "penicillin g",
"pos": [
28,
40
]
} |
antibacterial antibiotics ( penicillin g , polymixin b , cephalosporin c and streptomycin ) greatly reduced ( p less than .05 ) ammonia formation from casein . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
0,
13
]
} | {
"id": "C0032535",
"name": "polymixin b",
"pos": [
43,
54
]
} |
antibacterial antibiotics ( penicillin g , polymixin b , cephalosporin c and streptomycin ) greatly reduced ( p less than .05 ) ammonia formation from casein . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
0,
13
]
} | {
"id": "C0038425",
"name": "streptomycin",
"pos": [
77,
89
]
} |
although the antimalarial activity , hemolytic and methemoglobinemic side effects , and detoxification of primaquine are all thought to depend on various biotransformation products of the drug , their site and mechanism of formation and degradation are unknown and their specific biologic effects remain very poorly understood , particularly in humans . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial",
"pos": [
13,
25
]
} | {
"id": "C0033126",
"name": "primaquine",
"pos": [
106,
116
]
} |
the effect of artemisinin combined with standard antimalarials against chloroquine-sensitive and chloroquine-resistant strains of plasmodium falciparum in vitro . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarials",
"pos": [
49,
62
]
} | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
97,
108
]
} |
the activity of artemisinin ( qinghaosu ) in combination with some commonly-used antimalarial drugs was tested in vitro against a chloroquine-sensitive ( nf54 ) and a chloroquine-resistant ( k1 ) strain of plasmodium falciparum . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial",
"pos": [
81,
93
]
} | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
167,
178
]
} |
tocainide is a derivative of lidocaine with anti-arrhythmic action and , unlike lidocaine , can be used for oral treatment . | therapeutic_class_of | {
"id": "C0003195",
"name": "anti-arrhythmic",
"pos": [
44,
59
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
80,
89
]
} |
the neuroleptic haloperidol was found to produce increased defecation in laboratory rats when tested in well habituated environments . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
4,
15
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
16,
27
]
} |
forty-one patients , presenting with complex ventricular arrhythmias , received antiarrhythmic treatment with amiodarone ( 600 mg/day in the first week , 400 mg/day in the second week , and 200 to 400 mg/day chronically ) , and were then controlled with periodic 24-hour ambulatory monitoring . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
80,
94
]
} | {
"id": "C0002598",
"name": "amiodarone",
"pos": [
110,
120
]
} |
when the comparison was made on the basis of all group 1a antiarrhythmic drugs ( quinidine , procainamide and disopyramide combined ) , persons with prolonged qtc intervals used these drugs more often than did those with normal qtc intervals ( p = 0.031 ) . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drugs",
"pos": [
58,
78
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
81,
90
]
} |
when the comparison was made on the basis of all group 1a antiarrhythmic drugs ( quinidine , procainamide and disopyramide combined ) , persons with prolonged qtc intervals used these drugs more often than did those with normal qtc intervals ( p = 0.031 ) . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drugs",
"pos": [
58,
78
]
} | {
"id": "C0033216",
"name": "procainamide",
"pos": [
93,
105
]
} |
when the comparison was made on the basis of all group 1a antiarrhythmic drugs ( quinidine , procainamide and disopyramide combined ) , persons with prolonged qtc intervals used these drugs more often than did those with normal qtc intervals ( p = 0.031 ) . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drugs",
"pos": [
58,
78
]
} | {
"id": "C0012702",
"name": "disopyramide",
"pos": [
110,
122
]
} |
the availability of disopyramide for clinical use in 1977 produced optimism for an effective antiarrhythmic agent that was free of the well-known immediate and late toxicities of quinidine and procainamide . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agent",
"pos": [
93,
113
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
179,
188
]
} |
the availability of disopyramide for clinical use in 1977 produced optimism for an effective antiarrhythmic agent that was free of the well-known immediate and late toxicities of quinidine and procainamide . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agent",
"pos": [
93,
113
]
} | {
"id": "C0033216",
"name": "procainamide",
"pos": [
193,
205
]
} |
controlled-release disopyramide is a promising addition to the antiarrhythmic formulary that may increase the clinical utility of disopyramide . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
63,
77
]
} | {
"id": "C0012702",
"name": "disopyramide",
"pos": [
130,
142
]
} |
the aldehydes found to be inhibitory against p. falciparum could contribute to both the non-antibody host responses against this parasite and the antimalarial effects of radical-generating compounds such as t-butyl hydroperoxide , hydrogen peroxide , alloxan , isouramil , divicine and primaquine . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial",
"pos": [
146,
158
]
} | {
"id": "C0033126",
"name": "primaquine",
"pos": [
286,
296
]
} |
the effects of the antiarrhythmic agent disopyramide was studied on responses from voltage-clamped endplates at the neuromuscular junction of the garter snake . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agent",
"pos": [
19,
39
]
} | {
"id": "C0012702",
"name": "disopyramide",
"pos": [
40,
52
]
} |
in all three patients receiving no antiarrhythmic drugs and in two pretreated with amiodarone , a rapid poorly tolerated ventricular tachyarrhythmia requiring cardioversion was induced by programmed ventricular stimulation with up to two extrastimuli . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drugs",
"pos": [
35,
55
]
} | {
"id": "C0002598",
"name": "amiodarone",
"pos": [
83,
93
]
} |
multiple-dose pharmacokinetics of the antimalarial drug fansimef ( pyrimethamine + sulfadoxine + mefloquine ) in healthy subjects . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial",
"pos": [
38,
50
]
} | {
"id": "C0025153",
"name": "mefloquine",
"pos": [
97,
107
]
} |
fansimef is a new antimalarial combination containing pyrimethamine , sulfadoxine and mefloquine in the weight proportions 1 + 20 + 10 . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial",
"pos": [
18,
30
]
} | {
"id": "C0025153",
"name": "mefloquine",
"pos": [
86,
96
]
} |
appropriate therapy implied compliance with all of the criteria for appropriate intravenous metronidazole use with respect to indication , dose , dosage frequency , timing of perioperative prophylaxis , duration of use , and concurrent antimicrobial drug use , when metronidazole was prescribed for prophylaxis , empiric treatment or treatment of a documented infection ( documented treatment ) . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial drug",
"pos": [
236,
254
]
} | {
"id": "C0025872",
"name": "metronidazole",
"pos": [
266,
279
]
} |
it was shown in experiments in vitro that neuroleptics haloperidol and sulpiride , antidepressants desipramine and amitriptyline , nootropic agent piracetam , benzodiazepine tranquillizer phenazepam , psychostimulant phenamine and agonist of gaba a-receptors tetrahydroisoxazolopyridinol depending on the concentration in the micromolar range decrease k+-stimulated release of 3h-d-aspartic acid from rat brain cortex synaptosomes . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
42,
54
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
55,
66
]
} |
it was shown in experiments in vitro that neuroleptics haloperidol and sulpiride , antidepressants desipramine and amitriptyline , nootropic agent piracetam , benzodiazepine tranquillizer phenazepam , psychostimulant phenamine and agonist of gaba a-receptors tetrahydroisoxazolopyridinol depending on the concentration in the micromolar range decrease k+-stimulated release of 3h-d-aspartic acid from rat brain cortex synaptosomes . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
83,
98
]
} | {
"id": "C0011685",
"name": "desipramine",
"pos": [
99,
110
]
} |
it was shown in experiments in vitro that neuroleptics haloperidol and sulpiride , antidepressants desipramine and amitriptyline , nootropic agent piracetam , benzodiazepine tranquillizer phenazepam , psychostimulant phenamine and agonist of gaba a-receptors tetrahydroisoxazolopyridinol depending on the concentration in the micromolar range decrease k+-stimulated release of 3h-d-aspartic acid from rat brain cortex synaptosomes . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
83,
98
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
115,
128
]
} |
the excretion and metabolism in rats of difenoxine , the pharmacologically active metabolite of the antidiarrheal agent diphenoxylate . | therapeutic_class_of | {
"id": "C0003292",
"name": "antidiarrheal agent",
"pos": [
100,
119
]
} | {
"id": "C0012525",
"name": "diphenoxylate",
"pos": [
120,
133
]
} |
[ combined effect of histones and antibiotics in vitro and in vivo . antibacterial effect of histone fractions of the calf thymus in combination with streptomycin and tubazid ] . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
69,
82
]
} | {
"id": "C0038425",
"name": "streptomycin",
"pos": [
150,
162
]
} |
amoxycillin ( alpha-amino-p-hydroxybenzylpenicillin ) is a new semi-synthetic penicillin with a broad spectrum of antibacterial activity similar to that of ampicillin . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
114,
127
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
156,
166
]
} |
the antiseptic properties of povidone-iodine and tincture of metaphen used topically on the tooth surface . | therapeutic_class_of | {
"id": "C0003205",
"name": "antiseptic",
"pos": [
4,
14
]
} | {
"id": "C0032857",
"name": "povidone-iodine",
"pos": [
29,
44
]
} |
although the ester has in vitro antimicrobial activity per se when evaluated in brain heart infusion broth , the in vivo antibacterial activity seen in mice and rats reflects primarily the efficient hydrolysis of the ester to carbenicillin . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
121,
134
]
} | {
"id": "C0006976",
"name": "carbenicillin",
"pos": [
226,
239
]
} |
effect of lipoproteins on hemolytic and antifungal activity of amphotericin b and other polyene antibiotics . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
40,
50
]
} | {
"id": "C0002679",
"name": "amphotericin b",
"pos": [
63,
77
]
} |
the authors measured serum neuroleptic levels by radioreceptor assay in 30 schizophrenic patients receiving haloperidol , fluphenazine , chlorpromazine , molindone , thiothixene , or trifluoperazine . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
27,
38
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
108,
119
]
} |
the authors measured serum neuroleptic levels by radioreceptor assay in 30 schizophrenic patients receiving haloperidol , fluphenazine , chlorpromazine , molindone , thiothixene , or trifluoperazine . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
27,
38
]
} | {
"id": "C0026388",
"name": "molindone",
"pos": [
154,
163
]
} |
the authors measured serum neuroleptic levels by radioreceptor assay in 30 schizophrenic patients receiving haloperidol , fluphenazine , chlorpromazine , molindone , thiothixene , or trifluoperazine . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
27,
38
]
} | {
"id": "C0039955",
"name": "thiothixene",
"pos": [
166,
177
]
} |
to test the dopamine hypothesis of schizophrenia the authors measured specific 3h-neuroleptic/dopamine binding sites in three dopamin-rich regions of 59 postmortem normal human brains and 50 postmortem brains from schizophrenic patients using 3h-haloperidol and 3h-spiperone . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
82,
93
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
246,
257
]
} |
comparison of geometric mean minimum inhibitory concentrations of all antimicrobial agents tested suggested that b. catarrhalis was most susceptible to cefoxitin , erythromycin , and tetracycline . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial agents",
"pos": [
70,
90
]
} | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
164,
176
]
} |
comparison of geometric mean minimum inhibitory concentrations of all antimicrobial agents tested suggested that b. catarrhalis was most susceptible to cefoxitin , erythromycin , and tetracycline . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial agents",
"pos": [
70,
90
]
} | {
"id": "C0039644",
"name": "tetracycline",
"pos": [
183,
195
]
} |
by 8 h after dosage , levels of cyclacillin in serum declined below the minimal inhibitory concentration and the inferior antibacterial activity of cyclacillin ( compared with that of amipicillin ) suggest that cyclacillin is not a promising alternative to ampicillin for single-dose treatment of gonorrhea . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
122,
135
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
257,
267
]
} |
a new class i antiarrhythmic , flecainide , was investigated in 10 patients to assess short-term efficacy and safety . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
14,
28
]
} | {
"id": "C0016229",
"name": "flecainide",
"pos": [
31,
41
]
} |
a major metabolite of the antiepileptic drug mephenytoin ( 3-methyl-5-ethyl-5-phenylhydantoin ) has been identified in urine after a single oral dose of 100 mg of mephenytoin in man . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drug",
"pos": [
26,
44
]
} | {
"id": "C0025381",
"name": "mephenytoin",
"pos": [
163,
174
]
} |
a major metabolite of the antiepileptic drug mephenytoin ( 3-methyl-5-ethyl-5-phenylhydantoin ) has been identified in urine after a single oral dose of 100 mg of mephenytoin in man . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drug",
"pos": [
26,
44
]
} | {
"id": "C0031507",
"name": "phenylhydantoin",
"pos": [
78,
93
]
} |
several of the mono- and diarylcarbinols exhibited potent local anesthetic and antiarrhythmic activity , in some cases greater than that of quinidine . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
79,
93
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
140,
149
]
} |
conformational energy maps have been computed for the antiepileptic agents phenytoin and cannabidiol by the quantum-mechanical method of perturbative configuration interaction with localized orbitals ( pcilo ) . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic agents",
"pos": [
54,
74
]
} | {
"id": "C0031507",
"name": "phenytoin",
"pos": [
75,
84
]
} |
at therapeutic concentrations , the antibacterial activity of trimethoprim was not increased by the addition of sulphadiazine . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
36,
49
]
} | {
"id": "C0041041",
"name": "trimethoprim",
"pos": [
62,
74
]
} |
at therapeutic concentrations , the antibacterial activity of trimethoprim was not increased by the addition of sulphadiazine . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
36,
49
]
} | {
"id": "C0038675",
"name": "sulphadiazine",
"pos": [
112,
125
]
} |
the antidepressant drugs imipramine , amitriptyline and org gb94 did not reverse or potentiate the effect of lithium chloride on these monoamines or tyrosine . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant drugs",
"pos": [
4,
24
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
25,
35
]
} |
the antidepressant drugs imipramine , amitriptyline and org gb94 did not reverse or potentiate the effect of lithium chloride on these monoamines or tyrosine . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant drugs",
"pos": [
4,
24
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
38,
51
]
} |
the influence of factors which inhibit 5-hydoxytryptamine ( 5-ht ) synthesis , i.e . p-chlorophenylalanine ( pcpa ) and p-chloroamphetamine ( pca ) , on cataleptic action of the neuroleptics : spiroperiodol , pimozide , reserpine and fluphenazine was studied . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
178,
190
]
} | {
"id": "C0031935",
"name": "pimozide",
"pos": [
209,
217
]
} |
in vitro antibacterial activities of ampicillin and amoxycillin were compared against pigmented and non-pigmented strains of serratia marcescens . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
9,
22
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
37,
47
]
} |
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