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|---|---|---|---|
in vitro antibacterial activities of ampicillin and amoxycillin were compared against pigmented and non-pigmented strains of serratia marcescens . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
9,
22
]
} | {
"id": "C0002645",
"name": "amoxycillin",
"pos": [
52,
63
]
} |
routine antimicrobial sensitivity testing of bacterial isolates showed that the antibiotic most likely to be effective against the organisms isolated was a cephalosporin or a tetracycline . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial",
"pos": [
8,
21
]
} | {
"id": "C0039644",
"name": "tetracycline",
"pos": [
175,
187
]
} |
the anthelmintic efficacy of mebendazole against adult fasciola hepatica and a concurrent mixed nematode infection in sheep . | therapeutic_class_of | {
"id": "C0003158",
"name": "anthelmintic",
"pos": [
4,
16
]
} | {
"id": "C0025023",
"name": "mebendazole",
"pos": [
29,
40
]
} |
[ comparative studies on the antibacterial activity of 3 semisynthetic penicillins by polfa : dicloxacillin , syntarpen and ampicillin ] . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
29,
42
]
} | {
"id": "C0012093",
"name": "dicloxacillin",
"pos": [
94,
107
]
} |
[ comparative studies on the antibacterial activity of 3 semisynthetic penicillins by polfa : dicloxacillin , syntarpen and ampicillin ] . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
29,
42
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
124,
134
]
} |
[ monitoring plasma levels of some antiepileptic drugs ( phenobarbital , diphenylhydantoin , carbamazepine ) in the lennox-gastaut syndrome and in other forms of epilepsy ( partial and secondary generalized ) in childhood ] . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drugs",
"pos": [
35,
54
]
} | {
"id": "C0031507",
"name": "diphenylhydantoin",
"pos": [
73,
90
]
} |
in antibacterial susceptibility testing by the agar plate dilution method with 252 strains of clostridium perfringens , 22 strains of c. novyi type a and 7 of c. novyi type b , with 21 strains of c. bifermentans , 12 strains of c. sordellii and 18 of c. sporogenes , the majority of the strains were inhibited by penicillin g , cephalothin , chloramphenicol , erythromycin , tinidazole and metronidazole . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
3,
16
]
} | {
"id": "C0008168",
"name": "chloramphenicol",
"pos": [
342,
357
]
} |
the functional state of the testis due to the effect of antibacterial therapy was studied in 50 patients suffering from chronic inflammatory diseases of the urinary-genital system and treated with neomycin , streptomycin , tetracycline , furadonin and furagin . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
56,
69
]
} | {
"id": "C0027603",
"name": "neomycin",
"pos": [
197,
205
]
} |
the functional state of the testis due to the effect of antibacterial therapy was studied in 50 patients suffering from chronic inflammatory diseases of the urinary-genital system and treated with neomycin , streptomycin , tetracycline , furadonin and furagin . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
56,
69
]
} | {
"id": "C0038425",
"name": "streptomycin",
"pos": [
208,
220
]
} |
synergistic antifungal activity of 5-fluorocytosine ( 5-fc ) and amphotericin b was studied using an abbreviated checkerboard titration scheme . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
12,
22
]
} | {
"id": "C0016278",
"name": "5-fc",
"pos": [
54,
58
]
} |
synergistic antifungal activity of 5-fluorocytosine ( 5-fc ) and amphotericin b was studied using an abbreviated checkerboard titration scheme . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
12,
22
]
} | {
"id": "C0002679",
"name": "amphotericin b",
"pos": [
65,
79
]
} |
the author describes the notions that led to initiation of controlled trials of long-term medication with antiarrhythmic drugs following myocardial infarction , and reviews reports of controlled trials with diphenylhydantoin , alprenolol , and procaine amide . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drugs",
"pos": [
106,
126
]
} | {
"id": "C0033216",
"name": "procaine amide",
"pos": [
244,
258
]
} |
the antiepileptic drugs diphenylhydantoin and phenobarbital were measured in serum by a new commercially available enzyme immunoassay procedure ( `` '' emit , '' '' syva corp. ) . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drugs",
"pos": [
4,
23
]
} | {
"id": "C0031507",
"name": "diphenylhydantoin",
"pos": [
24,
41
]
} |
the results are reported of a double-blind controlled trial of a recently introduced major tranquilizer thiothixene ( navane , pfizer ) against chlorpromazine in 24 chronic schizophrenics in the royal edinburgh hospital , edinburgh , scotland . | therapeutic_class_of | {
"id": "C0040615",
"name": "major tranquilizer",
"pos": [
85,
103
]
} | {
"id": "C0039955",
"name": "thiothixene",
"pos": [
104,
115
]
} |
hyperactivity was inhibited by the peripheral administration of large doses of many neuroleptic agents , e.g . haloperidol , fluphenazine , but only pimozide and oxiperomide inhibited the other forms of dyskinetic movements . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic agents",
"pos": [
84,
102
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
111,
122
]
} |
hyperactivity was inhibited by the peripheral administration of large doses of many neuroleptic agents , e.g . haloperidol , fluphenazine , but only pimozide and oxiperomide inhibited the other forms of dyskinetic movements . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic agents",
"pos": [
84,
102
]
} | {
"id": "C0031935",
"name": "pimozide",
"pos": [
149,
157
]
} |
the mechanisms underlying the dissociation of the extrapyramidal and antipsychotic properties of haloperidol as compared to clozapine were explored by studying the effects of these drugs on dopamine metabolism in the straitum and tuberculum olfactorium ( to ) of the rat . | therapeutic_class_of | {
"id": "C0040615",
"name": "antipsychotic",
"pos": [
69,
82
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
97,
108
]
} |
the lysosomal stabilizer and anti-malarial agent , chloroquine , stimulated the respiration and motility of fresh and aged bovine spermatozoa stored in vitro . | therapeutic_class_of | {
"id": "C0003374",
"name": "anti-malarial",
"pos": [
29,
42
]
} | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
51,
62
]
} |
the antidepressants lowered blood pressure transiently and increased the heart rate , doxepin and amitriptyline being more effective than nortriptyline and protriptyline . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
4,
19
]
} | {
"id": "C0013085",
"name": "doxepin",
"pos": [
86,
93
]
} |
the antidepressants lowered blood pressure transiently and increased the heart rate , doxepin and amitriptyline being more effective than nortriptyline and protriptyline . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
4,
19
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
98,
111
]
} |
the antidepressants lowered blood pressure transiently and increased the heart rate , doxepin and amitriptyline being more effective than nortriptyline and protriptyline . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
4,
19
]
} | {
"id": "C0028420",
"name": "nortriptyline",
"pos": [
138,
151
]
} |
the antidepressants lowered blood pressure transiently and increased the heart rate , doxepin and amitriptyline being more effective than nortriptyline and protriptyline . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
4,
19
]
} | {
"id": "C0033743",
"name": "protriptyline",
"pos": [
156,
169
]
} |
the 'in vitro ' effect of the anthelmintics thiabendazole , mebendazole and ivermectin on succinate dehydrogenase and fumarate reductase activities from the above isolates is also described . | therapeutic_class_of | {
"id": "C0003158",
"name": "anthelmintics",
"pos": [
30,
43
]
} | {
"id": "C0025023",
"name": "mebendazole",
"pos": [
60,
71
]
} |
the neuroleptics haloperidol and thioridazine blocked the effect of apomorphine on eating time , but not on eating rate . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
4,
16
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
17,
28
]
} |
for a level of 0.70 mmol/kg ip of cocl2 ( slightly higher than its ld50 ) , the ip administration of chelating agents at a 2:1 and 5:1 mole ratio resulted in a significant antidotal action for l-cysteine , n-acetyl-cysteine , l-histidine , glutathione , d , l-penicillamine , dmsa , dtpa and edta . | therapeutic_class_of | {
"id": "C0003295",
"name": "antidotal",
"pos": [
172,
181
]
} | {
"id": "C0001047",
"name": "n-acetyl-cysteine",
"pos": [
206,
223
]
} |
electrically kindled hippocampal seizures in rats were used to evaluate the acute effects of the antidepressants amitriptyline , imipramine , desipramine , bupropion , maprotiline , and trazodone on behavioral and electrical convulsions . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
97,
112
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
113,
126
]
} |
electrically kindled hippocampal seizures in rats were used to evaluate the acute effects of the antidepressants amitriptyline , imipramine , desipramine , bupropion , maprotiline , and trazodone on behavioral and electrical convulsions . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
97,
112
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
129,
139
]
} |
electrically kindled hippocampal seizures in rats were used to evaluate the acute effects of the antidepressants amitriptyline , imipramine , desipramine , bupropion , maprotiline , and trazodone on behavioral and electrical convulsions . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
97,
112
]
} | {
"id": "C0011685",
"name": "desipramine",
"pos": [
142,
153
]
} |
we explored the antibacterial activity of phosphanilic acid ( p ) , an analog of sulfanilic acid , alone and in combination with trimethoprim ( t ; | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
16,
29
]
} | {
"id": "C0041041",
"name": "trimethoprim",
"pos": [
129,
141
]
} |
the in vitro susceptibilities of 34 to 73 clinical isolates of clostridium difficile to 24 antimicrobial agents , including 18 beta-lactams , 4 fluoroquinolones , clindamycin , and metronidazole were examined . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial agents",
"pos": [
91,
111
]
} | {
"id": "C0025872",
"name": "metronidazole",
"pos": [
181,
194
]
} |
these patients did not respond to an average of 3.1 +/- antiarrhythmic drugs , including amiodarone in 12 patients . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drugs",
"pos": [
56,
76
]
} | {
"id": "C0002598",
"name": "amiodarone",
"pos": [
89,
99
]
} |
fifty-four patients ( 34 outpatients , 20 inpatients ) fulfilling research diagnostic criteria for definite major depressive disorder were enrolled in a double-blind study comparing the antidepressant effects of alprazolam versus desipramine . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
186,
200
]
} | {
"id": "C0011685",
"name": "desipramine",
"pos": [
230,
241
]
} |
the patients , who came from regions with high resistance to antimalarials , were divided into three groups receiving single-dose treatment as follows : a combination of 280 mg mefloquine , 800 mg sulfadoxine and 40 mg pyrimethamine ; | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarials",
"pos": [
61,
74
]
} | {
"id": "C0025153",
"name": "mefloquine",
"pos": [
177,
187
]
} |
the characteristics of the inhibition of electric eel acetylcholinesterase ( ache ) and horse serum butyrylcholinesterase ( bche ) by the antimalarial agents mefloquine , chloroquine , amodiaquine and amopyroquine were determined . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial agents",
"pos": [
138,
157
]
} | {
"id": "C0025153",
"name": "mefloquine",
"pos": [
158,
168
]
} |
the characteristics of the inhibition of electric eel acetylcholinesterase ( ache ) and horse serum butyrylcholinesterase ( bche ) by the antimalarial agents mefloquine , chloroquine , amodiaquine and amopyroquine were determined . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial agents",
"pos": [
138,
157
]
} | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
171,
182
]
} |
the antibacterial spectrum of imipenem exceeds any antibiotic investigated to date and includes gram-positive , gram-negative , and anaerobic organisms . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0020933",
"name": "imipenem",
"pos": [
30,
38
]
} |
administration ( 20 mg/kg i.p . ) of antiepileptic 5-phenylhydantoins phenytoin , ethotoin , mephenytoin , and selected metabolites to mice over a period of 16 days produced lower serum concentrations of cholesterol and triglycerides with most of the compounds studied . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic",
"pos": [
37,
50
]
} | {
"id": "C0031507",
"name": "phenytoin",
"pos": [
95,
104
]
} |
administration ( 20 mg/kg i.p . ) of antiepileptic 5-phenylhydantoins phenytoin , ethotoin , mephenytoin , and selected metabolites to mice over a period of 16 days produced lower serum concentrations of cholesterol and triglycerides with most of the compounds studied . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic",
"pos": [
37,
50
]
} | {
"id": "C0015046",
"name": "ethotoin",
"pos": [
82,
90
]
} |
administration ( 20 mg/kg i.p . ) of antiepileptic 5-phenylhydantoins phenytoin , ethotoin , mephenytoin , and selected metabolites to mice over a period of 16 days produced lower serum concentrations of cholesterol and triglycerides with most of the compounds studied . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic",
"pos": [
37,
50
]
} | {
"id": "C0025381",
"name": "mephenytoin",
"pos": [
93,
104
]
} |
these in vivo studies suggest that antiepileptic phenylhydantoins , when used in chronic therapy in man , could possibly act as hypolipidemic agents . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic",
"pos": [
35,
48
]
} | {
"id": "C0031507",
"name": "phenylhydantoins",
"pos": [
49,
65
]
} |
antidepressive drugs can change the affinity of [ 3h ] imipramine and [ 3h ] paroxetine binding to platelet and neuronal membranes . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressive",
"pos": [
0,
14
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
55,
65
]
} |
the authors refer on the antiarrhythmic efficacy of quinidine polygalacturonate and prajmalium bitartrate combination for the treatment of refractory recurrent paroxysmal atrial fibrillation , in one patient . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
25,
39
]
} | {
"id": "C0084273",
"name": "quinidine polygalacturonate",
"pos": [
52,
79
]
} |
photon correlation spectroscopy ( pcs ) has been used to examine the aggregation in aqueous nacl solution of a series of antidepressant and antihistamine drugs ( hydrochlorides of imipramine , clomipramine , amitriptyline , butriptyline , protriptyline , doxepin , dothiepin , iprindole , diphenhydramine , bromodiphenhydramine , orphenadrine ) propranolol hydrochloride and propantheline bromide . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
121,
135
]
} | {
"id": "C0589978",
"name": "hydrochlorides",
"pos": [
162,
176
]
} |
photon correlation spectroscopy ( pcs ) has been used to examine the aggregation in aqueous nacl solution of a series of antidepressant and antihistamine drugs ( hydrochlorides of imipramine , clomipramine , amitriptyline , butriptyline , protriptyline , doxepin , dothiepin , iprindole , diphenhydramine , bromodiphenhydramine , orphenadrine ) propranolol hydrochloride and propantheline bromide . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
121,
135
]
} | {
"id": "C0009010",
"name": "clomipramine",
"pos": [
193,
205
]
} |
photon correlation spectroscopy ( pcs ) has been used to examine the aggregation in aqueous nacl solution of a series of antidepressant and antihistamine drugs ( hydrochlorides of imipramine , clomipramine , amitriptyline , butriptyline , protriptyline , doxepin , dothiepin , iprindole , diphenhydramine , bromodiphenhydramine , orphenadrine ) propranolol hydrochloride and propantheline bromide . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
121,
135
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
208,
221
]
} |
photon correlation spectroscopy ( pcs ) has been used to examine the aggregation in aqueous nacl solution of a series of antidepressant and antihistamine drugs ( hydrochlorides of imipramine , clomipramine , amitriptyline , butriptyline , protriptyline , doxepin , dothiepin , iprindole , diphenhydramine , bromodiphenhydramine , orphenadrine ) propranolol hydrochloride and propantheline bromide . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
121,
135
]
} | {
"id": "C0033743",
"name": "protriptyline",
"pos": [
239,
252
]
} |
photon correlation spectroscopy ( pcs ) has been used to examine the aggregation in aqueous nacl solution of a series of antidepressant and antihistamine drugs ( hydrochlorides of imipramine , clomipramine , amitriptyline , butriptyline , protriptyline , doxepin , dothiepin , iprindole , diphenhydramine , bromodiphenhydramine , orphenadrine ) propranolol hydrochloride and propantheline bromide . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
121,
135
]
} | {
"id": "C0013085",
"name": "doxepin",
"pos": [
255,
262
]
} |
in order to test whether co-administration of a serotonin precursor with antidepressant drugs could potentiate the effects of the antidepressants on monoamines or adrenoceptors in rat brain , l-tryptophan ( 20 mg/kg ) was administered to rats daily for 7 or 15 days , either alone or in combination with desipramine ( 10 mg/kg ) or amitriptyline ( 10 mg/kg ) . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
130,
145
]
} | {
"id": "C0011685",
"name": "desipramine",
"pos": [
304,
315
]
} |
in order to test whether co-administration of a serotonin precursor with antidepressant drugs could potentiate the effects of the antidepressants on monoamines or adrenoceptors in rat brain , l-tryptophan ( 20 mg/kg ) was administered to rats daily for 7 or 15 days , either alone or in combination with desipramine ( 10 mg/kg ) or amitriptyline ( 10 mg/kg ) . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
130,
145
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
332,
345
]
} |
while clavulanic acid exhibits little antibacterial activity , its action is synergistic with that of ticarcillin making 100 % of staphylococci and 84.2 % of gram negative bacilli susceptible . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
38,
51
]
} | {
"id": "C0040193",
"name": "ticarcillin",
"pos": [
102,
113
]
} |
antibacterial activity of cefotiam associated with gentamicin , tobramycin , netilmicin , or amikacin against enterobacteriaceae strains either moderately susceptible ( mic = 4 to 32 micrograms/ml , 14 strains ) or resistant ( mic = 64 to 512 micrograms/ml , 22 strains ) to cefotiam was studied using the checkerboard method . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
0,
13
]
} | {
"id": "C0040341",
"name": "tobramycin",
"pos": [
64,
74
]
} |
antibacterial activity of cefotiam associated with gentamicin , tobramycin , netilmicin , or amikacin against enterobacteriaceae strains either moderately susceptible ( mic = 4 to 32 micrograms/ml , 14 strains ) or resistant ( mic = 64 to 512 micrograms/ml , 22 strains ) to cefotiam was studied using the checkerboard method . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
0,
13
]
} | {
"id": "C0027780",
"name": "netilmicin",
"pos": [
77,
87
]
} |
antibacterial activity of cefotiam associated with gentamicin , tobramycin , netilmicin , or amikacin against enterobacteriaceae strains either moderately susceptible ( mic = 4 to 32 micrograms/ml , 14 strains ) or resistant ( mic = 64 to 512 micrograms/ml , 22 strains ) to cefotiam was studied using the checkerboard method . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
0,
13
]
} | {
"id": "C0002499",
"name": "amikacin",
"pos": [
93,
101
]
} |
possible implications of this finding for the antimanic efficacy of cbz and for mechanisms of action are discussed . | therapeutic_class_of | {
"id": "C0242911",
"name": "antimanic",
"pos": [
46,
55
]
} | {
"id": "C0006949",
"name": "cbz",
"pos": [
68,
71
]
} |
to further characterize the role of beta-adrenergic receptor regulation in the actions of antidepressants , the effects of chronic treatment with desipramine , zimelidine and bupropion on beta-adrenergic receptors in rat brain membrane preparations were studied . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
90,
105
]
} | {
"id": "C0011685",
"name": "desipramine",
"pos": [
146,
157
]
} |
[ efficacy of a single intravenous dose of antimicrobials in prevention against post-appendectomy wound infection : a blind comparative study of metronidazole , clindamycin and a placebo ] . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobials",
"pos": [
43,
57
]
} | {
"id": "C0025872",
"name": "metronidazole",
"pos": [
145,
158
]
} |
contraindications for the antiseptic therapy with pvp-iodine result from the investigations concerning the cytotoxicity and resorption of iodine . | therapeutic_class_of | {
"id": "C0003205",
"name": "antiseptic",
"pos": [
26,
36
]
} | {
"id": "C0032857",
"name": "pvp-iodine",
"pos": [
50,
60
]
} |
approximately two-thirds of the isolates were tested for their antimicrobial sensitivity patterns and the degree of sensitivity for p haemolytica a1 , the most frequently isolated serotype , was chloramphenicol ( 100 per cent ) , sulphamethoxazole trimethoprim ( 98 per cent ) , oxytetracycline ( 80 per cent ) , ampicillin ( 85 per cent ) , penicillin ( 82 per cent ) , streptomycin ( 3 per cent ) and lincomycin ( 1 per cent ) . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial",
"pos": [
63,
76
]
} | {
"id": "C0030092",
"name": "oxytetracycline",
"pos": [
279,
294
]
} |
24-hour systemic antimicrobial prophylaxis with gentamicin and metronidazole , or metronidazole alone , in elective colorectal surgery after mechanical bowel preparation with mannitol and whole gut irrigation . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial",
"pos": [
17,
30
]
} | {
"id": "C0025872",
"name": "metronidazole",
"pos": [
82,
95
]
} |
in a prospective randomized trial , systemic antimicrobial prophylaxis with metronidazole and gentamicin was compared to the administration of metronidazole alone in elective colorectal surgery . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial",
"pos": [
45,
58
]
} | {
"id": "C0025872",
"name": "metronidazole",
"pos": [
143,
156
]
} |
augmentin , a new orally absorbed broadspectrum antibacterial agent comprising of amoxycillin trihydrate and potassium clavulanate , was investigated in the treatment of gonococcal urethritis in ibadan , nigeria , where penicillinase producing neisseria gonorrhoeae ( ppng ) constitute about 80 % of the circulating strains of gonococci . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial agent",
"pos": [
48,
67
]
} | {
"id": "C0521900",
"name": "amoxycillin trihydrate",
"pos": [
82,
104
]
} |
ventricular arrhythmias , especially sustained attacks of ventricular tachycardia systematically detected by ambulant ecg , ought to be prevented by anti-arrhythmics : beta-blockers , in combination or not with anti-arrhythmics of class i , amiodarone , propafenone , etc . | therapeutic_class_of | {
"id": "C0003195",
"name": "anti-arrhythmics",
"pos": [
149,
165
]
} | {
"id": "C0002598",
"name": "amiodarone",
"pos": [
241,
251
]
} |
ventricular arrhythmias , especially sustained attacks of ventricular tachycardia systematically detected by ambulant ecg , ought to be prevented by anti-arrhythmics : beta-blockers , in combination or not with anti-arrhythmics of class i , amiodarone , propafenone , etc . | therapeutic_class_of | {
"id": "C0003195",
"name": "anti-arrhythmics",
"pos": [
149,
165
]
} | {
"id": "C0033429",
"name": "propafenone",
"pos": [
254,
265
]
} |
the in vitro antibacterial activity of sch 34343 against 1,328 strains of clinical isolates was compared with those of imipenem and ceftazidime . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
13,
26
]
} | {
"id": "C0020933",
"name": "imipenem",
"pos": [
119,
127
]
} |
the in vitro antibacterial activity of sch 34343 against 1,328 strains of clinical isolates was compared with those of imipenem and ceftazidime . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
13,
26
]
} | {
"id": "C0007559",
"name": "ceftazidime",
"pos": [
132,
143
]
} |
a new straightforward photometric method for the assay of the antimalarial drug chloroquine and its metabolites in urine is described . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial drug",
"pos": [
62,
79
]
} | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
80,
91
]
} |
in 23 patients treated with the iodine-containing antiarrhythmic drug amiodarone , the plasma concentrations of amiodarone , desethylamiodarone and iodine have been studied . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drug",
"pos": [
50,
69
]
} | {
"id": "C0002598",
"name": "amiodarone",
"pos": [
133,
143
]
} |
canine digitalis arrhythmia as a model for detecting na-channel blocking antiarrhythmic drugs : a comparative study using other canine arrhythmia models and the new antiarrhythmic drugs , propafenone , tocainide , and sun 1165 . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drugs",
"pos": [
73,
93
]
} | {
"id": "C0033429",
"name": "propafenone",
"pos": [
188,
199
]
} |
antiarrhythmic effects of three new drugs , propafenone , tocainide , and sun 1165 , were examined using three canine ventricular arrhythmia models , i.e. , digitalis , adrenaline and two-stage coronary ligation arrhythmias . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
0,
14
]
} | {
"id": "C0033429",
"name": "propafenone",
"pos": [
44,
55
]
} |
side effects are more clearly different among the antidepressants with demonstrably fewer cardiac effects ( i.e . ecg changes , orthostatic hypotension ) for buproprion , mianserin , nomifensine , and trazodone in the geriatric group compared to older agents such as amitriptyline and imipramine . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
50,
65
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
267,
280
]
} |
side effects are more clearly different among the antidepressants with demonstrably fewer cardiac effects ( i.e . ecg changes , orthostatic hypotension ) for buproprion , mianserin , nomifensine , and trazodone in the geriatric group compared to older agents such as amitriptyline and imipramine . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
50,
65
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
285,
295
]
} |
the antibacterial activity of azt against 16 clinical isolates were determined in comparison with those of abpc , cpz , lmox and ctx . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0004521",
"name": "azt",
"pos": [
30,
33
]
} |
however , antibacterial activity of azt against gram-positive bacteria was inferior to that against gram-negative bacteria , i.e. , against the strains of s. aureus ( 16 ) and s. pyogenes ( 4 ) , those mics were more than 400 micrograms/ml and 3.13 micrograms/ml , respectively . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
10,
23
]
} | {
"id": "C0004521",
"name": "azt",
"pos": [
36,
39
]
} |
the antibacterial activities of azt against the clinical isolates of e. coli , k. pneumoniae and p. aeruginosa were measured by the agar dilution method with inoculum size of 10 ( 6 ) cells/ml . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0004521",
"name": "azt",
"pos": [
32,
35
]
} |
[ on the demonstration of antimalarials in the body fluids and excreta . i. an improved and simplified field test for determination of chloroquine ( resochin ) in the urine ] . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarials",
"pos": [
26,
39
]
} | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
135,
146
]
} |
3 the conventional antidepressant , desipramine , preferentially down-regulated beta 1-adrenoceptors whereas the non-selective beta-adrenoceptor agonist ( +/- ) -clenbuterol preferentially down-regulated beta 2-adrenoceptors . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
19,
33
]
} | {
"id": "C0011685",
"name": "desipramine",
"pos": [
36,
47
]
} |
it is concluded that the 5-ht3 receptor antagonist gr38032f , and the neuroleptic agents fluphenazine , sulpiride and haloperidol , can reduce raised mesolimbic dopaminergic activity in the rat and marmoset . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
70,
81
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
118,
129
]
} |
plasma neuroleptic and prolactin levels , week-by-week systemic drug availability and parkinsonism showed less variation between injections with haloperidol than with fluphenazine . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
7,
18
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
145,
156
]
} |
in patients with ventricular arrhythmias refractory to other antiarrhythmic agents , propafenone 450 to 1200 mg/day suppressed arrhythmias in 63 % of patients ( in long term therapy 66 % ) . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agents",
"pos": [
61,
82
]
} | {
"id": "C0033429",
"name": "propafenone",
"pos": [
85,
96
]
} |
a limited number of comparisons with other antiarrhythmic drugs indicate that the antiarrhythmic efficacy of propafenone is superior or similar to that of quinidine , disopyramide and tocainide , and comparable to that of lignocaine ( lidocaine ) , flecainide and metoprolol against ventricular arrhythmias and a smaller number of atrial arrhythmias . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
43,
57
]
} | {
"id": "C0033429",
"name": "propafenone",
"pos": [
109,
120
]
} |
a limited number of comparisons with other antiarrhythmic drugs indicate that the antiarrhythmic efficacy of propafenone is superior or similar to that of quinidine , disopyramide and tocainide , and comparable to that of lignocaine ( lidocaine ) , flecainide and metoprolol against ventricular arrhythmias and a smaller number of atrial arrhythmias . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
43,
57
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
155,
164
]
} |
a limited number of comparisons with other antiarrhythmic drugs indicate that the antiarrhythmic efficacy of propafenone is superior or similar to that of quinidine , disopyramide and tocainide , and comparable to that of lignocaine ( lidocaine ) , flecainide and metoprolol against ventricular arrhythmias and a smaller number of atrial arrhythmias . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
43,
57
]
} | {
"id": "C0012702",
"name": "disopyramide",
"pos": [
167,
179
]
} |
a limited number of comparisons with other antiarrhythmic drugs indicate that the antiarrhythmic efficacy of propafenone is superior or similar to that of quinidine , disopyramide and tocainide , and comparable to that of lignocaine ( lidocaine ) , flecainide and metoprolol against ventricular arrhythmias and a smaller number of atrial arrhythmias . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
43,
57
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
235,
244
]
} |
a limited number of comparisons with other antiarrhythmic drugs indicate that the antiarrhythmic efficacy of propafenone is superior or similar to that of quinidine , disopyramide and tocainide , and comparable to that of lignocaine ( lidocaine ) , flecainide and metoprolol against ventricular arrhythmias and a smaller number of atrial arrhythmias . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
43,
57
]
} | {
"id": "C0016229",
"name": "flecainide",
"pos": [
249,
259
]
} |
antidepressants for cancer pain and other painful syndromes with deafferentation component : comparison of amitriptyline and trazodone . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
0,
15
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
107,
120
]
} |
the authors report a clinical multicentre experience with antidepressant agents ( trazodone and amitriptyline ) in the treatment of chronic cancer pain with deafferentation component . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant agents",
"pos": [
58,
79
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
96,
109
]
} |
some of these compounds ( e.g. , 11 , 16 , 26 and 27 ) showed an excellent wide spectrum of in vitro antibacterial activity including activity against pseudomonas aeruginosa and greater stability than imipenem toward the dehydropeptidase-i . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
101,
114
]
} | {
"id": "C0020933",
"name": "imipenem",
"pos": [
201,
209
]
} |
the in-vitro antimicrobial action of therapeutic concentrations of metronidazole against bacteroides fragilis and six different strains of enterobacteriaceae in pure and mixed cultures have been studied . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial",
"pos": [
13,
26
]
} | {
"id": "C0025872",
"name": "metronidazole",
"pos": [
67,
80
]
} |
antimicrobial synergy between metronidazole and spiramycin was noted against bacteroides spp . in abscesses caused in mice by subcutaneous injection of bacteroides spp . alone or in combination with s. aureus . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial",
"pos": [
0,
13
]
} | {
"id": "C0025872",
"name": "metronidazole",
"pos": [
30,
43
]
} |
the antimicrobial synergy in vitro and in vivo between metronidazole and spiramycin may have clinical implications that deserve to be further investigated . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial",
"pos": [
4,
17
]
} | {
"id": "C0025872",
"name": "metronidazole",
"pos": [
55,
68
]
} |
although this may be an important antiarrhythmic effect , the extent by which in vivo concentrations of propranolol may reduce the clinical antiarrhythmic efficacy of mexiletine is likely to be negligible . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
34,
48
]
} | {
"id": "C0025887",
"name": "mexiletine",
"pos": [
167,
177
]
} |
in combination with other antifungal agents only cholic acid exhibited synergism with amphotericin b , whilst the imidazole antifungal agents inhibited the action of the bile salts . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal agents",
"pos": [
26,
43
]
} | {
"id": "C0002679",
"name": "amphotericin b",
"pos": [
86,
100
]
} |
[ studies on ampicillin and amoxicillin derivatives . i. synthesis and antibacterial activity of n- ( pyrido [ 2,3-d ] pyrimidine-6-carbonyl ) -ampicillin and -amoxicillin derivatives ] . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
71,
84
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
144,
154
]
} |
[ studies on ampicillin and amoxicillin derivatives . i. synthesis and antibacterial activity of n- ( pyrido [ 2,3-d ] pyrimidine-6-carbonyl ) -ampicillin and -amoxicillin derivatives ] . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
71,
84
]
} | {
"id": "C0002645",
"name": "amoxicillin",
"pos": [
160,
171
]
} |
the antiarrhythmic drugs procainamide ( 1.0 x 10 ( -4 ) m ) , mexiletine ( 1.0 x 10 ( -5 ) m ) and propranolol ( 1.0 x 10 ( -4 ) m ) depressed both oap and triggered activity . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drugs",
"pos": [
4,
24
]
} | {
"id": "C0033216",
"name": "procainamide",
"pos": [
25,
37
]
} |
the antiarrhythmic drugs procainamide ( 1.0 x 10 ( -4 ) m ) , mexiletine ( 1.0 x 10 ( -5 ) m ) and propranolol ( 1.0 x 10 ( -4 ) m ) depressed both oap and triggered activity . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drugs",
"pos": [
4,
24
]
} | {
"id": "C0025887",
"name": "mexiletine",
"pos": [
62,
72
]
} |
to clarify the central action of peripherally administered ceruletide , we examined the effects of ceruletide and four different classes of neuroleptics , i.e . haloperidol , chlorpromazine , oxypertine and sulpiride , on the discriminated avoidance response ( dar ) in rats . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
140,
152
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
161,
172
]
} |
value of antibiotic levels in serum and cardiac vegetations for predicting antibacterial effect of ceftriaxone in experimental escherichia coli endocarditis . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
75,
88
]
} | {
"id": "C0007561",
"name": "ceftriaxone",
"pos": [
99,
110
]
} |
in a rabbit model of escherichia coli endocarditis , we studied the penetration into infected vegetations and the antibacterial effect of ceftriaxone . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
114,
127
]
} | {
"id": "C0007561",
"name": "ceftriaxone",
"pos": [
138,
149
]
} |
the antibacterial activities of ciprofloxacin and ceftazidime against klebsiella pneumoniae in vitro and in vivo were compared . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0007559",
"name": "ceftazidime",
"pos": [
50,
61
]
} |
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