text
stringlengths 57
1.72k
| relation
stringclasses 125
values | h
dict | t
dict |
|---|---|---|---|
the high antibacterial activity of ciprofloxacin in the lungs as compared with that of ceftazidime was also reflected in its therapeutic efficacy in k. pneumoniae pneumonia and septicemia in leukopenic rats when these infections were treated at 6-h intervals over 4 days , starting at 5 h after bacterial inoculation . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
9,
22
]
} | {
"id": "C0007559",
"name": "ceftazidime",
"pos": [
87,
98
]
} |
regarding the antibacterial activity of both drugs against k. pneumoniae in relation to the bacterial growth rate in vitro and in the lungs of leukopenic rats , ciprofloxacin killed k. pneumoniae organisms that were not actively growing , whereas ceftazidime did not . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
14,
27
]
} | {
"id": "C0007559",
"name": "ceftazidime",
"pos": [
247,
258
]
} |
although all these antidepressant agents have qualitatively similar depressant effects , the inhibitory potency on the electrical activity of sinoatrial node was : imipramine greater than maprotiline greater than mianserin . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
19,
33
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
164,
174
]
} |
the membrane stabilizing antiarrhythmic agents : quinidine and lidocaine proved to be effective in preventing or moderating ischemia induced shifts in k+i and na+i concentrations however did not affect ca2+i content . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agents",
"pos": [
25,
46
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
49,
58
]
} |
the membrane stabilizing antiarrhythmic agents : quinidine and lidocaine proved to be effective in preventing or moderating ischemia induced shifts in k+i and na+i concentrations however did not affect ca2+i content . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agents",
"pos": [
25,
46
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
63,
72
]
} |
in contrast to most of the other antimicrobials so far tested , ofloxacin exerted almost no influence upon the microflora-associated characteristics investigated . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobials",
"pos": [
33,
47
]
} | {
"id": "C0028902",
"name": "ofloxacin",
"pos": [
64,
73
]
} |
[ comparative studies of the antiarrhythmic activity of prolonged action quaternary ammonium derivatives of trimecaine ( g-104 ) and lidocaine ( qx-572 ) ] . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
29,
43
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
133,
142
]
} |
the antiarrhythmic activity of quaternary ammonium derivatives of trimecaine ( g-104 ) and lidocaine ( qx-572 ) was studied on models of arrhythmias induced in dogs by coronary artery occlusion and strophanthin intoxication and in rats by intravenous administration of aconitine . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
4,
18
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
91,
100
]
} |
the quassinoids bruceoside-a [ 1 ] , brusatol [ 2 ] , and bruceolide [ 3 ] were tested for antimalarial activity in vitro against the chloroquine-resistant ( smith ) isolates of plasmodium falciparum . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial",
"pos": [
91,
103
]
} | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
134,
145
]
} |
these results demonstrate that 1 ) the antidepressant activity of quinupramine can not be attributed to inhibition of monoamine uptake , 2 ) unchanged quinupramine penetrates into the cns and affects some of the processes of neurotransmission and 3 ) the pharmacological activities of imipramine , when administered orally , may be attributed to desipramine , the metabolite formed . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
39,
53
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
285,
295
]
} |
these results demonstrate that 1 ) the antidepressant activity of quinupramine can not be attributed to inhibition of monoamine uptake , 2 ) unchanged quinupramine penetrates into the cns and affects some of the processes of neurotransmission and 3 ) the pharmacological activities of imipramine , when administered orally , may be attributed to desipramine , the metabolite formed . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
39,
53
]
} | {
"id": "C0011685",
"name": "desipramine",
"pos": [
346,
357
]
} |
cardiovascular effects of paroxetine , a newly developed antidepressant , in anesthetized dogs in comparison with those of imipramine , amitriptyline and clomipramine . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
57,
71
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
123,
133
]
} |
cardiovascular effects of paroxetine , a newly developed antidepressant , in anesthetized dogs in comparison with those of imipramine , amitriptyline and clomipramine . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
57,
71
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
136,
149
]
} |
cardiovascular effects of paroxetine , a newly developed antidepressant , in anesthetized dogs in comparison with those of imipramine , amitriptyline and clomipramine . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
57,
71
]
} | {
"id": "C0009010",
"name": "clomipramine",
"pos": [
154,
166
]
} |
the cardiovascular effects of various antidepressant drugs including paroxetine , imipramine , amitriptyline and clomipramine , administered intravenously , have been assessed . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
38,
52
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
82,
92
]
} |
the cardiovascular effects of various antidepressant drugs including paroxetine , imipramine , amitriptyline and clomipramine , administered intravenously , have been assessed . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
38,
52
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
95,
108
]
} |
the cardiovascular effects of various antidepressant drugs including paroxetine , imipramine , amitriptyline and clomipramine , administered intravenously , have been assessed . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
38,
52
]
} | {
"id": "C0009010",
"name": "clomipramine",
"pos": [
113,
125
]
} |
in contrast , other antimicrobial agents ( clindamycin , erythromycin , ethambutol ) are highly concentrated by these cells , as well as josamycin , erythromycin and spiramycin in vivo . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial agents",
"pos": [
20,
40
]
} | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
149,
161
]
} |
five antimicrobial agents , ciprofloxacin , ticarcillin , piperacillin , aztreonam and gentamicin , were compared both in vitro ( mic 's , time-kill studies ) and in vivo , in the treatment of experimental proteus mirabilis pyelonephritis in mice . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial agents",
"pos": [
5,
25
]
} | {
"id": "C0008809",
"name": "ciprofloxacin",
"pos": [
28,
41
]
} |
the antibacterial activities of ciprofloxacin versus ceftazidime against klebsiella pneumoniae in vitro and in vivo were compared . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0007559",
"name": "ceftazidime",
"pos": [
53,
64
]
} |
however , laa are to be detected according to d-penicillamine-like , levamisol-like etc . actions , which can be disclosed in the adjuvant arthritis as well as in the b. pertussis-vaccine pleuritis in rats the latter model best by including parameters of inflammatory exudate cells . | therapeutic_class_of | {
"id": "C0003191",
"name": "laa",
"pos": [
10,
13
]
} | {
"id": "C0030817",
"name": "penicillamine",
"pos": [
48,
61
]
} |
various tricyclic ( amitriptyline , desipramine , imipramine ) , maoi ( clorgyline , moclobemide , nialamide , pargyline , toloxatone ) and atypical antidepressants ( bupropion , citalopram , indalpine , mianserin , nomifensine , viloxazine ) were tested and compared with psychostimulants ( d-amphetamine , caffeine ) , neuroleptics ( chlorpromazine , haloperidol , sulpiride ) , anxiolytics ( clobazam , diazepam ) and agents acting on the cholinergic system ( atropine , oxotremorine ) . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
321,
333
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
353,
364
]
} |
the in vitro activity of the broad-spectrum antifungals miconazole , ketoconazole and itraconazole was evaluated by the decimal dilution method in liquid media , for respectively 2511 , 1536 and 1859 strains of yeasts belonging to 31 species . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungals",
"pos": [
44,
55
]
} | {
"id": "C0025942",
"name": "miconazole",
"pos": [
56,
66
]
} |
the in vitro activity of the broad-spectrum antifungals miconazole , ketoconazole and itraconazole was evaluated by the decimal dilution method in liquid media , for respectively 2511 , 1536 and 1859 strains of yeasts belonging to 31 species . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungals",
"pos": [
44,
55
]
} | {
"id": "C0022625",
"name": "ketoconazole",
"pos": [
69,
81
]
} |
comparative antibacterial activity of two novel ureidopenicillins ( azlocillin and piperacillin ) , carbenicillin and ampicillin against 170 clinical strains of enterobacteriaceae and 43 strains of pseudomonadaceae was studied . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
12,
25
]
} | {
"id": "C0031955",
"name": "piperacillin",
"pos": [
83,
95
]
} |
comparative antibacterial activity of two novel ureidopenicillins ( azlocillin and piperacillin ) , carbenicillin and ampicillin against 170 clinical strains of enterobacteriaceae and 43 strains of pseudomonadaceae was studied . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
12,
25
]
} | {
"id": "C0006976",
"name": "carbenicillin",
"pos": [
100,
113
]
} |
comparative antibacterial activity of two novel ureidopenicillins ( azlocillin and piperacillin ) , carbenicillin and ampicillin against 170 clinical strains of enterobacteriaceae and 43 strains of pseudomonadaceae was studied . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
12,
25
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
118,
128
]
} |
higher antibacterial activity of azlocillin and piperacillin evident from lower frequency of resistant strains and lower mics for the majority of the isolates was shown . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
7,
20
]
} | {
"id": "C0031955",
"name": "piperacillin",
"pos": [
48,
60
]
} |
synergistic antifungal activity and reduced toxicity of liposomal amphotericin b combined with gramicidin s or nf . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
12,
22
]
} | {
"id": "C1145701",
"name": "liposomal amphotericin b",
"pos": [
56,
80
]
} |
this study demonstrated synergistic antifungal activity of free and liposomal forms of ampb when combined with the free and liposomal forms of gramicidin s and gramicidin nf against five candida strains . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
36,
46
]
} | {
"id": "C1145701",
"name": "liposomal",
"pos": [
124,
133
]
} |
the remaining antiepileptics ( acetazolamide , up to 1,000 mg/kg ; carbamazepine and diphenylhydantoin , up to 50 mg/kg ; ethosuximide , 500 mg/kg and trimethadione , 400 mg/kg ) were totally ineffective in this respect . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptics",
"pos": [
14,
28
]
} | {
"id": "C0031507",
"name": "diphenylhydantoin",
"pos": [
85,
102
]
} |
the remaining antiepileptics ( acetazolamide , up to 1,000 mg/kg ; carbamazepine and diphenylhydantoin , up to 50 mg/kg ; ethosuximide , 500 mg/kg and trimethadione , 400 mg/kg ) were totally ineffective in this respect . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptics",
"pos": [
14,
28
]
} | {
"id": "C0015043",
"name": "ethosuximide",
"pos": [
122,
134
]
} |
the remaining antiepileptics ( acetazolamide , up to 1,000 mg/kg ; carbamazepine and diphenylhydantoin , up to 50 mg/kg ; ethosuximide , 500 mg/kg and trimethadione , 400 mg/kg ) were totally ineffective in this respect . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptics",
"pos": [
14,
28
]
} | {
"id": "C0041038",
"name": "trimethadione",
"pos": [
151,
164
]
} |
the sorption of the antifungal drug miconazole onto the plastics of infusion bags and intravenous administration sets has been investigated . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal drug",
"pos": [
20,
35
]
} | {
"id": "C0025942",
"name": "miconazole",
"pos": [
36,
46
]
} |
beside its antiarrhythmic properties , which in particular are used for the treatment of atrial fibrillation , quinidine is known to have alpha-adrenoceptor blocking properties . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
11,
25
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
111,
120
]
} |
we observed that sulbactam + ampicillin compound is enhanced and regained the antibacterial activity of ampicillin against some bacteria such as s. aureus , s. epidermidis and some gram negative microorganisms . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
78,
91
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
104,
114
]
} |
all 6 isolates of c. pseudodiphtheriticum were sensitive to nine antimicrobial agents which were six beta-lactam agents , gentamicin , minocycline and norfloxacin . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial agents",
"pos": [
65,
85
]
} | {
"id": "C0028365",
"name": "norfloxacin",
"pos": [
151,
162
]
} |
thus , the therapeutic index of the important antifungal agent amphotericin b is markedly improved via incorporation of the drug into liposomes . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal agent",
"pos": [
46,
62
]
} | {
"id": "C0002679",
"name": "amphotericin b",
"pos": [
63,
77
]
} |
some aspects of the antibacterial action of streptomycin against tubercle bacilli , including the influence upon the tetrazolium salt reducing activity of the bacilli . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
20,
33
]
} | {
"id": "C0038425",
"name": "streptomycin",
"pos": [
44,
56
]
} |
comparison of effects of two antimalarial agents , hydroxychloroquine sulfate and chloroquine phosphate , in patients with rheumatoid arthitis . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial agents",
"pos": [
29,
48
]
} | {
"id": "C0055447",
"name": "chloroquine phosphate",
"pos": [
82,
103
]
} |
the effect of an antidiarrhoeal agent , diphenoxylate , was analysed and it was shown that it retarded small bowel propulsion without influencing gastric evacuation . | therapeutic_class_of | {
"id": "C0003292",
"name": "antidiarrhoeal agent",
"pos": [
17,
37
]
} | {
"id": "C0012525",
"name": "diphenoxylate",
"pos": [
40,
53
]
} |
for the various antidepressants the degree of inhibition of the basal twitch responses ( desipramine greater than protriptyline greater than nortriptyline greater than maprotiline = imipramine greater than amitriptyline greater than viloxazine greater than iprindole much greater than zimelidine ) was highly correlated ( r = 0.914 ) with the potency for blockade of [ 3h ] -na uptake into rat brain synaptosomes . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
16,
31
]
} | {
"id": "C0011685",
"name": "desipramine",
"pos": [
89,
100
]
} |
for the various antidepressants the degree of inhibition of the basal twitch responses ( desipramine greater than protriptyline greater than nortriptyline greater than maprotiline = imipramine greater than amitriptyline greater than viloxazine greater than iprindole much greater than zimelidine ) was highly correlated ( r = 0.914 ) with the potency for blockade of [ 3h ] -na uptake into rat brain synaptosomes . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
16,
31
]
} | {
"id": "C0033743",
"name": "protriptyline",
"pos": [
114,
127
]
} |
for the various antidepressants the degree of inhibition of the basal twitch responses ( desipramine greater than protriptyline greater than nortriptyline greater than maprotiline = imipramine greater than amitriptyline greater than viloxazine greater than iprindole much greater than zimelidine ) was highly correlated ( r = 0.914 ) with the potency for blockade of [ 3h ] -na uptake into rat brain synaptosomes . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
16,
31
]
} | {
"id": "C0028420",
"name": "nortriptyline",
"pos": [
141,
154
]
} |
for the various antidepressants the degree of inhibition of the basal twitch responses ( desipramine greater than protriptyline greater than nortriptyline greater than maprotiline = imipramine greater than amitriptyline greater than viloxazine greater than iprindole much greater than zimelidine ) was highly correlated ( r = 0.914 ) with the potency for blockade of [ 3h ] -na uptake into rat brain synaptosomes . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
16,
31
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
182,
192
]
} |
for the various antidepressants the degree of inhibition of the basal twitch responses ( desipramine greater than protriptyline greater than nortriptyline greater than maprotiline = imipramine greater than amitriptyline greater than viloxazine greater than iprindole much greater than zimelidine ) was highly correlated ( r = 0.914 ) with the potency for blockade of [ 3h ] -na uptake into rat brain synaptosomes . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
16,
31
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
206,
219
]
} |
biochemical effects of antidepressant treatment -- studies of monoamine metabolites in cerebrospinal fluid and platelet [ 3h ] imipramine binding . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
23,
37
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
127,
137
]
} |
long-term ( 14 days ) treatment of mice with the antidepressant drug imipramine increased the number of gaba-b receptors in the cerebral cortex and also led to an increase in the potentiation of norepinephrine-induced camp accumulation by baclofen ( a gaba-b agonist ) in cortical slices . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant drug",
"pos": [
49,
68
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
69,
79
]
} |
the in-vitro interactions of four antimicrobial agents ( piperacillin , dibekacin , minocycline , norfloxacin ) and four antineoplastic agents ( mitomycin c , bleomycin , doxorubicin , 5-fluorouracil ) were examined by the chequerboard dilution method using 108 clinical isolates of four species of gram-negative bacilli . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial agents",
"pos": [
34,
54
]
} | {
"id": "C0028365",
"name": "norfloxacin",
"pos": [
98,
109
]
} |
among the antimicrobial agents , piperacillin showed the greatest degree of synergism and norfloxacin the least . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial agents",
"pos": [
10,
30
]
} | {
"id": "C0028365",
"name": "norfloxacin",
"pos": [
90,
101
]
} |
in-vitro antibacterial activity of imipenem compared with four other beta-lactam antibiotics ( ceftazidime , cefotaxime , piperacillin and azlocillin ) against 828 separate clinical isolates from a portuguese hospital . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
9,
22
]
} | {
"id": "C0020933",
"name": "imipenem",
"pos": [
35,
43
]
} |
in-vitro antibacterial activity of imipenem compared with four other beta-lactam antibiotics ( ceftazidime , cefotaxime , piperacillin and azlocillin ) against 828 separate clinical isolates from a portuguese hospital . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
9,
22
]
} | {
"id": "C0007559",
"name": "ceftazidime",
"pos": [
95,
106
]
} |
in-vitro antibacterial activity of imipenem compared with four other beta-lactam antibiotics ( ceftazidime , cefotaxime , piperacillin and azlocillin ) against 828 separate clinical isolates from a portuguese hospital . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
9,
22
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
109,
119
]
} |
in-vitro antibacterial activity of imipenem compared with four other beta-lactam antibiotics ( ceftazidime , cefotaxime , piperacillin and azlocillin ) against 828 separate clinical isolates from a portuguese hospital . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
9,
22
]
} | {
"id": "C0031955",
"name": "piperacillin",
"pos": [
122,
134
]
} |
antibacterial properties of imipenem with special reference to the activity against methicillin-resistant staphylococci , cefotaxime-resistant enterobacteriaceae and pseudomonas aeruginosa . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
0,
13
]
} | {
"id": "C0020933",
"name": "imipenem",
"pos": [
28,
36
]
} |
antibacterial properties of imipenem with special reference to the activity against methicillin-resistant staphylococci , cefotaxime-resistant enterobacteriaceae and pseudomonas aeruginosa . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
0,
13
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
122,
132
]
} |
data from susceptibility tests of clinical isolates confirmed that cefazolin ( cez ) , cefamandole and cefotiam ( ctm ) showed good antibacterial activity against s. aureus and cefmenoxime ( cmx ) was highly active against streptococcus spp. , but their susceptibilities to cez in 1984 were lower than in 1983 . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
132,
145
]
} | {
"id": "C0007546",
"name": "cez",
"pos": [
274,
277
]
} |
the antibacterial effect of penicillin against klebsiella spp . was found to be poor , while those of oral cephem antibiotics , cephalexin ( cex ) , cefaclor ( ccl ) , and cefazolin ( cez ) which is the cephem antibiotics of the so-called first generation and cefotiam ( ctm ) among other cephem antibiotics of the so-called second generation were relatively good . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
128,
138
]
} |
the antibacterial effect of penicillin against klebsiella spp . was found to be poor , while those of oral cephem antibiotics , cephalexin ( cex ) , cefaclor ( ccl ) , and cefazolin ( cez ) which is the cephem antibiotics of the so-called first generation and cefotiam ( ctm ) among other cephem antibiotics of the so-called second generation were relatively good . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0007537",
"name": "cefaclor",
"pos": [
149,
157
]
} |
the antibacterial effect of penicillin against klebsiella spp . was found to be poor , while those of oral cephem antibiotics , cephalexin ( cex ) , cefaclor ( ccl ) , and cefazolin ( cez ) which is the cephem antibiotics of the so-called first generation and cefotiam ( ctm ) among other cephem antibiotics of the so-called second generation were relatively good . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0007546",
"name": "cefazolin",
"pos": [
172,
181
]
} |
effects of coadministered antiepileptic drugs on free fractions of phenobarbital and valproic acid in epileptic children . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic",
"pos": [
26,
39
]
} | {
"id": "C0042291",
"name": "valproic acid",
"pos": [
85,
98
]
} |
in vitro antibacterial activity of imipenem-fosfomycin ( imp-fos ) combinations were studied against 31 clinical isolates of staphylococcus strains : methicillin susceptible s. aureus ( mssa , 11 strains ) , methicillin resistant s. aureus ( mrsa , 11 strains ) , methicillin resistant s. epidermidis ( mrse , 9 strains ) . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
9,
22
]
} | {
"id": "C0020933",
"name": "imipenem",
"pos": [
35,
43
]
} |
sodium hydroxide treatment of the benzoylbenzimidazole anthelmintics mebendazole and flubendazole produces yellow solutions that possess practically no fluorescence characteristics under various conditions . | therapeutic_class_of | {
"id": "C0003158",
"name": "anthelmintics",
"pos": [
55,
68
]
} | {
"id": "C0025023",
"name": "mebendazole",
"pos": [
69,
80
]
} |
virtually all antibacterial agents have been implicated , notable exceptions being vancomycin and parenterally administered aminoglycosides . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial agents",
"pos": [
14,
34
]
} | {
"id": "C0042313",
"name": "vancomycin",
"pos": [
83,
93
]
} |
the acute effects of antidepressants , maprotiline and amoxapine on serum prolactin and gonadotropin levels in normal women . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
21,
36
]
} | {
"id": "C0002644",
"name": "amoxapine",
"pos": [
55,
64
]
} |
the best antibacterial activity of ciprofloxacin and ceftazidime was expressed either by the lower mics and lower mbcs with respect to those of the other compounds or by a low mbc/mic ratio , which represent an important clinical advantage in clinical practice . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
9,
22
]
} | {
"id": "C0007559",
"name": "ceftazidime",
"pos": [
53,
64
]
} |
weight gain and prolactin levels in patients on long-term antipsychotic medication : a double-blind comparative trial of haloperidol decanoate and fluphenazine decanoate . | therapeutic_class_of | {
"id": "C0040615",
"name": "antipsychotic",
"pos": [
58,
71
]
} | {
"id": "C0062103",
"name": "haloperidol decanoate",
"pos": [
121,
142
]
} |
twelve patients ( eight men and four women ) suffering from manic depressive disorder who were receiving both lithium and antipsychotic medication had their antipsychotic changed to depot haloperidol decanoate , with their lithium medication remaining unchanged . | therapeutic_class_of | {
"id": "C0040615",
"name": "antipsychotic",
"pos": [
122,
135
]
} | {
"id": "C0062103",
"name": "haloperidol decanoate",
"pos": [
188,
209
]
} |
the effect of chronic administration of electroconvulsive shock and the antidepressant drug desipramine on binding to opioid receptors was studied in the cerebral cortex , the basal ganglia and the hippocampus of the forebrain of the rat . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant drug",
"pos": [
72,
91
]
} | {
"id": "C0011685",
"name": "desipramine",
"pos": [
92,
103
]
} |
this is a report of a 59-year-old man with a bjork aortic prosthetic valve and mitral commissurotomy with left ventricular dysfunction and recurrent ventricular tachycardia ( vt ) in spite of antiarrhythmic therapy with amiodarone . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
192,
206
]
} | {
"id": "C0002598",
"name": "amiodarone",
"pos": [
220,
230
]
} |
a detailed study was therefore carried out in vitro to compare the antibacterial activity against a wide range of clinical isolates and also the beta-lactamase stability of cefotaxime and desacetylcefotaxime , as well as other third-generation cephalosporins . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
67,
80
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
197,
207
]
} |
in the same age group given a single antiepileptic drug , the l/d ratio for pht steeply increased at the dose of 4 in adults or 5 mg/kg/day in children , while the ratio rather decreased for cbz and vpa . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drug",
"pos": [
37,
55
]
} | {
"id": "C0031507",
"name": "pht",
"pos": [
76,
79
]
} |
based on their effects on sleep-induction , -maintenance , and -architecture and rem measures , one may differentiate at least two subtypes : sedative antidepressants of the amitriptyline type and nonsedative antidepressants of the desipramine type . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
151,
166
]
} | {
"id": "C0011685",
"name": "desipramine",
"pos": [
232,
243
]
} |
this is of importance for pharmacopsychiatry , as some antidepressants like desipramine , nortriptyline , amitriptyline , imipramine ( and possibly maprotiline ) are metabolized by the same enzyme as debrisoquine . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
55,
70
]
} | {
"id": "C0011685",
"name": "desipramine",
"pos": [
76,
87
]
} |
this is of importance for pharmacopsychiatry , as some antidepressants like desipramine , nortriptyline , amitriptyline , imipramine ( and possibly maprotiline ) are metabolized by the same enzyme as debrisoquine . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
55,
70
]
} | {
"id": "C0028420",
"name": "nortriptyline",
"pos": [
90,
103
]
} |
this is of importance for pharmacopsychiatry , as some antidepressants like desipramine , nortriptyline , amitriptyline , imipramine ( and possibly maprotiline ) are metabolized by the same enzyme as debrisoquine . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
55,
70
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
106,
119
]
} |
this is of importance for pharmacopsychiatry , as some antidepressants like desipramine , nortriptyline , amitriptyline , imipramine ( and possibly maprotiline ) are metabolized by the same enzyme as debrisoquine . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
55,
70
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
122,
132
]
} |
the interaction with ethanol of antidepressant drugs , imipramine ( imi ) , amitryptiline ( ami ) and nomifensine ( nom ) , which differ in their activity on neuronal uptake of serotonin and catecholamines , was studied in the duration of narcosis in mice , normal and pretreated with p-chlorophenylalanine ( pcpa ) or alphamethyl-p-tyrosine ( ampt ) and compared with similar experiments with pentobarbital . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant drugs",
"pos": [
32,
52
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
55,
65
]
} |
the interaction with ethanol of antidepressant drugs , imipramine ( imi ) , amitryptiline ( ami ) and nomifensine ( nom ) , which differ in their activity on neuronal uptake of serotonin and catecholamines , was studied in the duration of narcosis in mice , normal and pretreated with p-chlorophenylalanine ( pcpa ) or alphamethyl-p-tyrosine ( ampt ) and compared with similar experiments with pentobarbital . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant drugs",
"pos": [
32,
52
]
} | {
"id": "C0002600",
"name": "amitryptiline",
"pos": [
76,
89
]
} |
two psychopharmacological tests which usually predict neuroleptic activity were conducted after joint administration of piracetam and three neuroleptics ( haloperidol , fluphenazine and sulpiride ) chosen for their different chemical classes and dopaminergic affinities . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
140,
152
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
155,
166
]
} |
in conclusion , a critical factor causing hyperammonemia seemed to be the multiple use of antiepileptic drugs including vpa . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drugs",
"pos": [
90,
109
]
} | {
"id": "C0042291",
"name": "vpa",
"pos": [
120,
123
]
} |
the antiepileptics diazepam , phenytoin , flunarizine and phenobarbital did not yield marked effects on s-w patterns , but the rem and dsws latencies were affected . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptics",
"pos": [
4,
18
]
} | {
"id": "C0031507",
"name": "phenytoin",
"pos": [
30,
39
]
} |
the hypoactivity in rats induced by small doses of apomorphine , injected bilaterally into the nucleus accumbens area of the brain , could be antagonized by pretreatment with the neuroleptic-like neuropeptide des-enkephalin-gamma-endorphin ( de gamma e , beta-endorphin 6-17 ) as well as with the neuroleptic drugs haloperidol , sulpiride and clozapine injected into the accumbens . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic drugs",
"pos": [
297,
314
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
315,
326
]
} |
the neuroleptic pimozide produces an extinction-like decline in the runway and skinner box performance of rats rewarded with electrical stimulation of the medial forebrain bundle ( mfb ) in the lateral and posterior hypothalamus . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
4,
15
]
} | {
"id": "C0031935",
"name": "pimozide",
"pos": [
16,
24
]
} |
after treatment with the neuroleptic , pimozide , the first few trials fell in the range of normal primed performance when the rats were primed , and in the range of normal unprimed performance when they were not . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
25,
36
]
} | {
"id": "C0031935",
"name": "pimozide",
"pos": [
39,
47
]
} |
the following results were obtained : by the statistical analysis of the hrs scores no difference in the antidepressant properties of trazodone and amitriptyline can be demonstrated . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
105,
119
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
148,
161
]
} |
the present study evaluated the effects of some neuroleptics ( chlorpromazine , haloperidol , spiroperidol ) on general activity and avoidance behavior ( one-way and two-way ) in rats with lesions in the midbrain raphe nuclei ( the nucleus raphe medianus and nucleus raphe dorsalis ) . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
48,
60
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
80,
91
]
} |
although the antibacterial activity and wide spectrum of cefotaxime , coupled with its apparent safety and tolerability , make it a useful antibiotic for the treatment of serious nosocomial infections , it will frequently have to be employed with another agent -- i.e. , an aminoglycoside -- until the precise identification and in vitro susceptibility of the infecting organism is known . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
13,
26
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
57,
67
]
} |
[ studies on the in vitro antibacterial activities of homemade amikacin on the common bacterial pathogens ] . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
26,
39
]
} | {
"id": "C0002499",
"name": "amikacin",
"pos": [
63,
71
]
} |
augmentin is a new antibacterial formulation comprised of amoxicillin and the beta-lactamase inhibitor clavulanic acid . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
19,
32
]
} | {
"id": "C0002645",
"name": "amoxicillin",
"pos": [
58,
69
]
} |
several antimicrobial agents , including third-generation cephalosporins , the newer semisynthetic penicillins , and erythromycin , exhibited good activity against the organisms . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial agents",
"pos": [
8,
28
]
} | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
117,
129
]
} |
a limited structure-activity analysis of the central nervous system-mediated side effects of this compound and related analogs is made relative to the antipsychotic agent , haloperidol . | therapeutic_class_of | {
"id": "C0040615",
"name": "antipsychotic agent",
"pos": [
151,
170
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
173,
184
]
} |
modification of the piperidine 4-position substituents of haloperidol to give a 4- ( alpha , alpha-diphenylmethanol ) moiety has conveyed histamine h1 -antagonism to the anti-psychotic agent , haloperidol . | therapeutic_class_of | {
"id": "C0040615",
"name": "anti-psychotic agent",
"pos": [
170,
190
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
193,
204
]
} |
the influence of two antidepressants , iproniazid and imipramine , was examined on the antileukemic combination effect of reserpine with 1-gamma-chloropropyl-2-chloromethylpiperidine hydrobromide ( cap-2 ) , mitomycin c , or vinblastine on l1210 . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
21,
36
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
54,
64
]
} |
the atypical neuroleptics oxypertine , sulpiride , and clozapine , the classic neuroleptic haloperidol and metoclopramide have a similar action to de gamma e . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
13,
24
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
91,
102
]
} |
the peptides and atypical neuroleptics do not affect the dopamine response per se while the classic neuroleptics haloperidol and metoclopramide enhance the dopamine response . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
26,
38
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
113,
124
]
} |
it was found that a single intraperitoneal injection of 7.5 mg/kg of the antidepressant drugs clomipramine , nortriptyline and mianserine normalized the increased social interactions of the isolated rat to the level of the group-housed rat , without affecting the social behaviour of that animal . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant drugs",
"pos": [
73,
93
]
} | {
"id": "C0009010",
"name": "clomipramine",
"pos": [
94,
106
]
} |
it was found that a single intraperitoneal injection of 7.5 mg/kg of the antidepressant drugs clomipramine , nortriptyline and mianserine normalized the increased social interactions of the isolated rat to the level of the group-housed rat , without affecting the social behaviour of that animal . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant drugs",
"pos": [
73,
93
]
} | {
"id": "C0028420",
"name": "nortriptyline",
"pos": [
109,
122
]
} |
an opiate ( morphine ) , an opiate antagonist ( naloxone ) , a tranquilizer ( diazepam ) , a neuroleptic ( haloperidol ) and a psychostimulant ( amphetamine ) did not preferentially influence the social behaviour of the isolated rat . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
93,
104
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
107,
118
]
} |
the antidepressant [ 3h ] desmethylimipramine was bound to many neurones and glial cells in cerebellar , brain stem and spinal cord cultures . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
4,
18
]
} | {
"id": "C0011685",
"name": "desmethylimipramine",
"pos": [
26,
45
]
} |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.