text
stringlengths 57
1.72k
| relation
stringclasses 125
values | h
dict | t
dict |
|---|---|---|---|
its in vitro antibacterial activity , evaluated by the study of 43 reference strains and 1,177 clinical isolates , was found to be very similar to that of gentamicin , tobramycin , sisomicin and netilmicin on strains sensitive to these aminoglycosides ; | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
13,
26
]
} | {
"id": "C0040341",
"name": "tobramycin",
"pos": [
168,
178
]
} |
its in vitro antibacterial activity , evaluated by the study of 43 reference strains and 1,177 clinical isolates , was found to be very similar to that of gentamicin , tobramycin , sisomicin and netilmicin on strains sensitive to these aminoglycosides ; | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
13,
26
]
} | {
"id": "C0027780",
"name": "netilmicin",
"pos": [
195,
205
]
} |
ten of these antagonists were neuroleptics : benzquinamide , clebopride , bromopride , prochlorperazine , haloperidol , chlorpromazine , thiethylperazine , metoclopramide , droperidol , and pimozide blocked conditioned responding in dogs and apomorphine-induced stereotyped behavior in rats . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
30,
42
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
106,
117
]
} |
ten of these antagonists were neuroleptics : benzquinamide , clebopride , bromopride , prochlorperazine , haloperidol , chlorpromazine , thiethylperazine , metoclopramide , droperidol , and pimozide blocked conditioned responding in dogs and apomorphine-induced stereotyped behavior in rats . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
30,
42
]
} | {
"id": "C0031935",
"name": "pimozide",
"pos": [
190,
198
]
} |
the effects of acute and chronic administration of a new antidepressant , amoxapine , on serum prolactin levels were compared to the effects of loxapine , its parent compound , which is a widely used neuroleptic . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
57,
71
]
} | {
"id": "C0002644",
"name": "amoxapine",
"pos": [
74,
83
]
} |
the disrupting action of neuroleptic haloperidol on the amphetamine-induced stereotype is weakened in animals with ventral lesions and enhanced in those with dorsal lesions . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
25,
36
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
37,
48
]
} |
antiarrhythmic efficacy of amiodarone in recurrent ventricular tachycardia evaluated by multiple electrophysiological and ambulatory ecg recordings . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
0,
14
]
} | {
"id": "C0002598",
"name": "amiodarone",
"pos": [
27,
37
]
} |
numerous progresses are realized in the chemotherapy of mycoses , particularly in the field of deep mycoses due to 3 categories of systemic antifungal agents : polyenes ( oral nystatin , oral and intravenous amphotericin b ) , 5-fluorocytosine ( oral and intravenous ) and imidazole derivatives ( oral and intravenous miconazole , oral ketoconazole ) . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal agents",
"pos": [
140,
157
]
} | {
"id": "C0002679",
"name": "amphotericin b",
"pos": [
208,
222
]
} |
numerous progresses are realized in the chemotherapy of mycoses , particularly in the field of deep mycoses due to 3 categories of systemic antifungal agents : polyenes ( oral nystatin , oral and intravenous amphotericin b ) , 5-fluorocytosine ( oral and intravenous ) and imidazole derivatives ( oral and intravenous miconazole , oral ketoconazole ) . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal agents",
"pos": [
140,
157
]
} | {
"id": "C0016278",
"name": "5-fluorocytosine",
"pos": [
227,
243
]
} |
numerous progresses are realized in the chemotherapy of mycoses , particularly in the field of deep mycoses due to 3 categories of systemic antifungal agents : polyenes ( oral nystatin , oral and intravenous amphotericin b ) , 5-fluorocytosine ( oral and intravenous ) and imidazole derivatives ( oral and intravenous miconazole , oral ketoconazole ) . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal agents",
"pos": [
140,
157
]
} | {
"id": "C0025942",
"name": "miconazole",
"pos": [
318,
328
]
} |
numerous progresses are realized in the chemotherapy of mycoses , particularly in the field of deep mycoses due to 3 categories of systemic antifungal agents : polyenes ( oral nystatin , oral and intravenous amphotericin b ) , 5-fluorocytosine ( oral and intravenous ) and imidazole derivatives ( oral and intravenous miconazole , oral ketoconazole ) . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal agents",
"pos": [
140,
157
]
} | {
"id": "C0022625",
"name": "ketoconazole",
"pos": [
336,
348
]
} |
all had been taking prophylactic antimalarial medication , and some were given additional chloroquine in an attempt to elicit an exacerbation . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial medication",
"pos": [
33,
56
]
} | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
90,
101
]
} |
the effect of lithium and five neuroleptics ( melleril , chlorprotixen , chlorpromazine , tisercin , haloperidol ) on cytotoxic reactivity and absorption capacity of lymphocyte hla antigens a1 , 2 , 3 , 9 , 10 , 11 , b5 , 7 , 8 , 12 , 13 in vitro was studied . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
31,
43
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
101,
112
]
} |
used orally , in double-blind cross-over controlled trials conducted on 73 patients , disopyramide , a newly developed antiarrhythmic agent , was found to be more effective than an inert placebo ( lactose ) , with a statistically significant difference , and to be as effective as quinidine sulfate in suppressing ventricular and supraventricular premature beats . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agent",
"pos": [
119,
139
]
} | {
"id": "C0034415",
"name": "quinidine sulfate",
"pos": [
281,
298
]
} |
although antioxidants enhanced the antifungal properties of both amphotericin b and its methyl ester derivative , the effect was significantly more pronounced with amphotericin b . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
35,
45
]
} | {
"id": "C0002679",
"name": "amphotericin b",
"pos": [
164,
178
]
} |
a controlled multicenter study has been carried out in 46 patients with ventricular tachyarrhythmias to define the antiarrhythmic effect of disopyramide phosphate . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
115,
129
]
} | {
"id": "C0700534",
"name": "disopyramide",
"pos": [
140,
152
]
} |
analysis of the results showed a relationship between the antiarrhythmic effect and group mean plasma concentration of disopyramide . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
58,
72
]
} | {
"id": "C0012702",
"name": "disopyramide",
"pos": [
119,
131
]
} |
tolerance and haematological findings with antimalarials ( chloroquine and fansidar [ pyrimethamine plus sulfadoxine ] ) in adults and children during field trials in nigeria . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarials",
"pos": [
43,
56
]
} | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
59,
70
]
} |
the antiarrhythmic efficacy and pharmacokinetics of n-acetylprocainamide ( napa ) , the major metabolite of procainamide , were investigated in 23 patients with chronic , high frequency ventricular ectopic depolarizations . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
4,
18
]
} | {
"id": "C0033216",
"name": "procainamide",
"pos": [
108,
120
]
} |
this finding implies that estimates of the antiarrhythmic contribution of acecainide concentrations achieved during long-term procainamide therapy are unlikely to be meaningful in a given person . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
43,
57
]
} | {
"id": "C0033216",
"name": "procainamide",
"pos": [
126,
138
]
} |
the spectrum of antibacterial activity of cxd is identical with that of cephalexin ( cex ) , but cxd was twofold more effective than cex against escherichia coli and klebsiella pneumoniae , cxd was as stable to penicillinase as cex , but it was hydrolyzed by cephalosporinase , with a relative rate of hydrolysis similar to that of cex . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
16,
29
]
} | {
"id": "C0007716",
"name": "cex",
"pos": [
332,
335
]
} |
in vivo antibacterial activities of cxd and cex were compared using systemic infections of mice with e. coli and k. pneumoniae ; | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
8,
21
]
} | {
"id": "C0007716",
"name": "cex",
"pos": [
44,
47
]
} |
however , as a neuroleptic , when tested in dogs , haloperidol was 50 times more potent than chlorpromazine hcl and 180 times more potent than thioridazine . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
15,
26
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
51,
62
]
} |
the therapeutic safety indices ( cardiovascular effect dose/neuroleptic dose ) for haloperidol regarding alpha-adrenergic blockade , hypotension , myocardial depression and ventricular conduction delay were 4 , 145 , 235 and 125 , respectively , whereas these indices for chlorpromazine and for thioridazine were 0.06 , 2 , 4 , 6 and 0.05 , 1 , 3 and 1 , respectively . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
60,
71
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
83,
94
]
} |
in the series of antidepressants studied , mianserin was the most potent antagonist at presynaptic alpha-adrenoceptors , followed by trazodone , amitriptyline and nortriptyline in descending order of potency . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
17,
32
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
145,
158
]
} |
in the series of antidepressants studied , mianserin was the most potent antagonist at presynaptic alpha-adrenoceptors , followed by trazodone , amitriptyline and nortriptyline in descending order of potency . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
17,
32
]
} | {
"id": "C0028420",
"name": "nortriptyline",
"pos": [
163,
176
]
} |
these findings suggest that in addition to their sedative effect , several antidepressants , particularly amitriptyline , are likely to interact with ethanol by increasing its concentration in plasma . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
75,
90
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
106,
119
]
} |
the effects of morphine and oxotremorine on concentrations of 3,4-dihydroxyphenylacetic acid ( dopac ) in the rat striatum and tuberculum olfactorium ( to ) have been compared with the effects of the antipsychotic drugs haloperidol , chlorpromazine and clozapine . | therapeutic_class_of | {
"id": "C0040615",
"name": "antipsychotic",
"pos": [
200,
213
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
220,
231
]
} |
to clarify the etiology of neuroleptic-induced acute dystonic reactions , monkeys ( cercopithecus aethiops ) were treated with haloperidol at doses sufficient to evoke dystonia , and the effects of agents that influenced dopaminergic , cholinergic , or gabaergic neurotransmitters were evaluated . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
27,
38
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
127,
138
]
} |
antagonism by classical antiepileptics and sodium valproate of cefazolin in induced experimental epilepsy in rats . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptics",
"pos": [
24,
38
]
} | {
"id": "C0037567",
"name": "sodium valproate",
"pos": [
43,
59
]
} |
classical antiepileptic drugs ( diphenylhydantoin , phenobarbital and clonazepam as well as sodium valproate were able to counteract electroclinical disorders induced by cefazolin . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drugs",
"pos": [
10,
29
]
} | {
"id": "C0031507",
"name": "diphenylhydantoin",
"pos": [
32,
49
]
} |
classical antiepileptic drugs ( diphenylhydantoin , phenobarbital and clonazepam as well as sodium valproate were able to counteract electroclinical disorders induced by cefazolin . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drugs",
"pos": [
10,
29
]
} | {
"id": "C0037567",
"name": "sodium valproate",
"pos": [
92,
108
]
} |
the incidence of potentially toxic serum levels ( greater than or equal to 400 ng/ml ) was analyzed in a group of 196 monitored patients on a standard dosage regimen ( 75-225 mg/day ) of several antidepressants : imipramine , amitriptyline , nortriptyline , maprotiline and clomipramine . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
195,
210
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
213,
223
]
} |
the incidence of potentially toxic serum levels ( greater than or equal to 400 ng/ml ) was analyzed in a group of 196 monitored patients on a standard dosage regimen ( 75-225 mg/day ) of several antidepressants : imipramine , amitriptyline , nortriptyline , maprotiline and clomipramine . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
195,
210
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
226,
239
]
} |
the incidence of potentially toxic serum levels ( greater than or equal to 400 ng/ml ) was analyzed in a group of 196 monitored patients on a standard dosage regimen ( 75-225 mg/day ) of several antidepressants : imipramine , amitriptyline , nortriptyline , maprotiline and clomipramine . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
195,
210
]
} | {
"id": "C0028420",
"name": "nortriptyline",
"pos": [
242,
255
]
} |
the incidence of potentially toxic serum levels ( greater than or equal to 400 ng/ml ) was analyzed in a group of 196 monitored patients on a standard dosage regimen ( 75-225 mg/day ) of several antidepressants : imipramine , amitriptyline , nortriptyline , maprotiline and clomipramine . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
195,
210
]
} | {
"id": "C0009010",
"name": "clomipramine",
"pos": [
274,
286
]
} |
in the present study , we evaluated the antiarrhythmic interaction ( s ) of metoprolol and lidocaine in 16 dogs using the ventricular fibrillation threshold ( vft ) method . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
40,
54
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
91,
100
]
} |
while oral administration of the antidepressant , imipramine , alone had no significant effect on this response , the increase was significantly inhibited by administration of imipramine together with each of the following drugs over a period of 4 days : bupropion ( 21.0 mg/kg/day , p.o . ) , a selective inhibitor of the uptake of dopamine and nomifensine ( 10.6 mg/kg/day , p.o . ) , a relatively selective dopamine and a blocker of the uptake of noradrenaline . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
33,
47
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
176,
186
]
} |
the effect of buthobendin ( 2s,2 's isomer of n , n'-dimethyl n , n'-bis [ 1- ( 3',4',5'-trimethoxybenzoyloxy ) -butyl-2 ] -ethylenediamin e dihydrochloride ) , ( cravitenr ) on aerobic and anaerobic glycolysis in rabbit myocardial slices was compared with that of the biologically inactive isomer 2r,2 ' r and the well-known antiarrhythmic drugs quinidine and procainamide . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drugs",
"pos": [
326,
346
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
347,
356
]
} |
the effect of buthobendin ( 2s,2 's isomer of n , n'-dimethyl n , n'-bis [ 1- ( 3',4',5'-trimethoxybenzoyloxy ) -butyl-2 ] -ethylenediamin e dihydrochloride ) , ( cravitenr ) on aerobic and anaerobic glycolysis in rabbit myocardial slices was compared with that of the biologically inactive isomer 2r,2 ' r and the well-known antiarrhythmic drugs quinidine and procainamide . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drugs",
"pos": [
326,
346
]
} | {
"id": "C0033216",
"name": "procainamide",
"pos": [
361,
373
]
} |
the in vitro activity of lomefloxacin , a new fluorinated quinolone antimicrobial , was compared to that of enoxacin , norfloxacin , ofloxacin , imipenem , cefotaxime , ceftazidime , and tobramycin against 597 microorganisms isolated from bacteremic patients at a university hospital . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial",
"pos": [
68,
81
]
} | {
"id": "C0028365",
"name": "norfloxacin",
"pos": [
119,
130
]
} |
the in vitro activity of lomefloxacin , a new fluorinated quinolone antimicrobial , was compared to that of enoxacin , norfloxacin , ofloxacin , imipenem , cefotaxime , ceftazidime , and tobramycin against 597 microorganisms isolated from bacteremic patients at a university hospital . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial",
"pos": [
68,
81
]
} | {
"id": "C0028902",
"name": "ofloxacin",
"pos": [
133,
142
]
} |
to non-beta-lactam antimicrobial agents , resistant strains appeared at 31 % to gentamicin , 15 % to amikacin , 0.6 % to minocycline ( mino ) , 1 % to norfloxacin ( nflx ) and 65 % to fosfomycin ( fom ) . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial agents",
"pos": [
19,
39
]
} | {
"id": "C0028365",
"name": "norfloxacin",
"pos": [
151,
162
]
} |
in order to determine whether the new antiarrhythmic agent propafenone interacts stereoselectively with beta-adrenergic receptors , the potencies of both the ( - ) and ( + ) isomers were determined using in vitro binding assays . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agent",
"pos": [
38,
58
]
} | {
"id": "C0033429",
"name": "propafenone",
"pos": [
59,
70
]
} |
the antiarrhythmic activity similar to that of quinidine ( with ca . 20 times lower toxicity ) was found only for racemic 7-beta-hydroxyethyl-8- ( 1'-hydroxybut-2'-yl ) aminotheophylline 1 and its enantiomers 2 , 3 which did not differ markedly in their efficacy . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
4,
18
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
47,
56
]
} |
such a study has offered information about the status of endogenous hemin in plasmodium cells and the mode of interaction of antimalarial drugs of the chloroquine class therein . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial drugs",
"pos": [
125,
143
]
} | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
151,
162
]
} |
there are scattered reports of improvement or even cure with other neuroleptics or tricyclic antidepressants but , in general , these seem less effective than pimozide ( cashman & pollock , 1983 ; brotman & jenike , 1984 ; pylko & sicignan , 1985 ) . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
67,
79
]
} | {
"id": "C0031935",
"name": "pimozide",
"pos": [
159,
167
]
} |
five antimicrobial drugs ( ciprofloxacin , clindamycin , imipenem , penicillin g , and rifampin ) were examined for therapeutic efficacy in a murine model gas gangrene due to clostridium perfringens type a , following infection with large bacterial inocula . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial drugs",
"pos": [
5,
24
]
} | {
"id": "C0008809",
"name": "ciprofloxacin",
"pos": [
27,
40
]
} |
this review of methods for determining antimalarial drugs in biological fluids has focused on the various analytical techniques for the assay of chloroquine , quinine , amodiaquine , mefloquine , proguanil , pyrimethamine , sulphadoxine , primaquine and some of their metabolites . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial drugs",
"pos": [
39,
57
]
} | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
145,
156
]
} |
this review of methods for determining antimalarial drugs in biological fluids has focused on the various analytical techniques for the assay of chloroquine , quinine , amodiaquine , mefloquine , proguanil , pyrimethamine , sulphadoxine , primaquine and some of their metabolites . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial drugs",
"pos": [
39,
57
]
} | {
"id": "C0025153",
"name": "mefloquine",
"pos": [
183,
193
]
} |
this review of methods for determining antimalarial drugs in biological fluids has focused on the various analytical techniques for the assay of chloroquine , quinine , amodiaquine , mefloquine , proguanil , pyrimethamine , sulphadoxine , primaquine and some of their metabolites . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial drugs",
"pos": [
39,
57
]
} | {
"id": "C0008241",
"name": "proguanil",
"pos": [
196,
205
]
} |
this review of methods for determining antimalarial drugs in biological fluids has focused on the various analytical techniques for the assay of chloroquine , quinine , amodiaquine , mefloquine , proguanil , pyrimethamine , sulphadoxine , primaquine and some of their metabolites . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial drugs",
"pos": [
39,
57
]
} | {
"id": "C0033126",
"name": "primaquine",
"pos": [
239,
249
]
} |
chloroquine is still the most used antimalarial drug , and various methods of different complexity exist for the determination of chloroquine and its metabolites in biological fluids . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial",
"pos": [
35,
47
]
} | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
130,
141
]
} |
the in vitro antifungal activity of a novel series of cis- and trans-5- ( [ aryl or aryloxy ( or thio ) ] methyl ) -3- ( 1h-imidazol-1-ylmethyl ) -3- ( 2-thienyl ) -2-methylisoxazolidines ( 13-24 ) was evaluated and compared with ketoconazole . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
13,
23
]
} | {
"id": "C0022625",
"name": "ketoconazole",
"pos": [
230,
242
]
} |
the frequency-dependency and voltage-dependency of the suppressing effect of pirmenol , a novel antiarrhythmic agent , on the maximum upstroke velocity ( vmax ) of action potentials were examined and compared with those of disopyramide in guinea pig papillary muscles . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agent",
"pos": [
96,
116
]
} | {
"id": "C0012702",
"name": "disopyramide",
"pos": [
223,
235
]
} |
possible implications with respect to the broad spectrum of antiarrhythmic activity exhibited by am are considered . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
60,
74
]
} | {
"id": "C0002598",
"name": "am",
"pos": [
97,
99
]
} |
this atypical biphasic pattern was not found when we used the secondary amine antidepressant drugs , desipramine , desmethylclomipramine , or fluoxetine , or used phenylethylamine as the substrate , or used rat rather than human brain tissue . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant drugs",
"pos": [
78,
98
]
} | {
"id": "C0011685",
"name": "desipramine",
"pos": [
101,
112
]
} |
testing of the susceptibility to 12 antimicrobial agents , including beta-lactams , aminoglycosides , ciprofloxacin , and erythromycin , was performed by broth microdilution on 78 consecutive clinical isolates of nocardia asteroides . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial agents",
"pos": [
36,
56
]
} | {
"id": "C0008809",
"name": "ciprofloxacin",
"pos": [
102,
115
]
} |
testing of the susceptibility to 12 antimicrobial agents , including beta-lactams , aminoglycosides , ciprofloxacin , and erythromycin , was performed by broth microdilution on 78 consecutive clinical isolates of nocardia asteroides . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial agents",
"pos": [
36,
56
]
} | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
122,
134
]
} |
the effects of the novel class ia/iii antiarrhythmic compound rs-87337 on canine myocardial conduction were compared with those of the class i antiarrhythmic disopyramide . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
38,
52
]
} | {
"id": "C0012702",
"name": "disopyramide",
"pos": [
158,
170
]
} |
the two drugs -- ceftriaxone ( rocephin ) and imipenem plus cilastatin ( tienam ) -- that have been taken into consideration in this study , having a similar antibacterial spectrum though with different kinetics , may have the same bq values in bronchial secretion versus haemophilus influenzae , klebsiella pneumoniae and streptococcus pneumoniae , when administered at different dosages , i.e . ceftriaxone 1 g ( i.v . ) every 24 h , imipenem 0.5 g ( i.v . ) every 8 h . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
158,
171
]
} | {
"id": "C0007561",
"name": "ceftriaxone",
"pos": [
397,
408
]
} |
the two drugs -- ceftriaxone ( rocephin ) and imipenem plus cilastatin ( tienam ) -- that have been taken into consideration in this study , having a similar antibacterial spectrum though with different kinetics , may have the same bq values in bronchial secretion versus haemophilus influenzae , klebsiella pneumoniae and streptococcus pneumoniae , when administered at different dosages , i.e . ceftriaxone 1 g ( i.v . ) every 24 h , imipenem 0.5 g ( i.v . ) every 8 h . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
158,
171
]
} | {
"id": "C0020933",
"name": "imipenem",
"pos": [
436,
444
]
} |
experimental studies on the antimalarial activity estimation by artesunate and artemether preparations per skin absorption . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial",
"pos": [
28,
40
]
} | {
"id": "C0052429",
"name": "preparations",
"pos": [
90,
102
]
} |
[ conformational analysis of anti-arrhythmia agents of the lidocaine series and a model for the mechanism of their action ] . | therapeutic_class_of | {
"id": "C0003195",
"name": "anti-arrhythmia agents",
"pos": [
29,
51
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
59,
68
]
} |
antibacterial activities of sbtpc against clinically isolated strains of haemophilus influenzae , haemophilus parainfluenzae , streptococcus pneumoniae , streptococcus pyogenes , streptococcus agalactiae , staphylococcus aureus , branhamella catarrhalis , and escherichia coli were compared with those of ampicillin ( abpc ) . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
0,
13
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
305,
315
]
} |
chronic administration of antipsychotic drugs such as haloperidol produces increases in nt concentration in the acc and caudate nucleus . | therapeutic_class_of | {
"id": "C0040615",
"name": "antipsychotic",
"pos": [
26,
39
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
54,
65
]
} |
clinical failures with penicillin therapy of these infections are reported in an increasing frequency and other antimicrobial agents such as clindamycin and metronidazole should be considered in the treatment of these failures . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial agents",
"pos": [
112,
132
]
} | {
"id": "C0025872",
"name": "metronidazole",
"pos": [
157,
170
]
} |
neuroleptics ( chlorpromazine , reserpine and haloperidol ) had not such an influence , though they somewhat increased the general activity of the animals . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
0,
12
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
46,
57
]
} |
these findings are in agreement with clinical data : the ic50 values correspond to clinically-relevant serum levels of gamma-vinyl gaba in humans only the ( s ) isomer showed an antiepileptic effect in animal models of epilepsy a delayed antiepileptic effect , after withdrawal of gamma-vinyl gaba , has been established in clinical studies . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic",
"pos": [
178,
191
]
} | {
"id": "C0048044",
"name": "gamma-vinyl gaba",
"pos": [
281,
297
]
} |
in a study restricted to the ventromedial nucleus of the hypothalamus , the tetralin compound ( 0.1-5 micrograms ) was shown to cause dose-dependent changes in gastric secretion , the reduction in concentration of acid being antagonised by the neuroleptic agents , sulpiride , metoclopramide , cis-flupenthixol and haloperidol , and by the alpha 2-adrenoceptor antagonist , yohimbine injected at the same site . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic agents",
"pos": [
244,
262
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
315,
326
]
} |
on the whole , while adinazolam seemed to develop an activity closer to that of a classical antidepressant like desipramine , alprazolam appeared to be more similar to the benzodiazepines on clonidine-induced aggression in mice . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
92,
106
]
} | {
"id": "C0011685",
"name": "desipramine",
"pos": [
112,
123
]
} |
the response profiles generated by those rats shifted to a lower reward magnitude were contrasted with either rats shifted from a 32 % sucrose solution to a no-reward ( plain tap water ) condition , or with rats maintained on a 32 % sucrose solution and administered the neuroleptic pim ( 0.5 mg/kg or 1.0 mg/kg ) . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
271,
282
]
} | {
"id": "C0031935",
"name": "pim",
"pos": [
283,
286
]
} |
a fixed-dose neuroleptic trial showed that thought disorder and auditory hallucinations respond rapidly to treatment with a da receptor blocker ( haloperidol ) , while no significant effect on other symptom cluster scores occurred during the initial 2 weeks of treatment . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
13,
24
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
146,
157
]
} |
about 70 % of the population received anti-malarials in november , 1981 and 8 million packets of chloroquine and primaquine were distributed by 70,000 health campaign workers and their assistants . | therapeutic_class_of | {
"id": "C0003374",
"name": "anti-malarials",
"pos": [
38,
52
]
} | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
97,
108
]
} |
about 70 % of the population received anti-malarials in november , 1981 and 8 million packets of chloroquine and primaquine were distributed by 70,000 health campaign workers and their assistants . | therapeutic_class_of | {
"id": "C0003374",
"name": "anti-malarials",
"pos": [
38,
52
]
} | {
"id": "C0033126",
"name": "primaquine",
"pos": [
113,
123
]
} |
procainamide is used in antiarrhythmic therapy , and the need to monitor the drug concentration as well as its major plasma metabolite , n-acetyl-procainamide , is well established . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
24,
38
]
} | {
"id": "C0033216",
"name": "procainamide",
"pos": [
146,
158
]
} |
the antibacterial activity of cefotetan , 8 other beta-lactam antibiotics and gentamicin , was tested in vitro on 288 recently isolated bacteria . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0007555",
"name": "cefotetan",
"pos": [
30,
39
]
} |
the antimalarial activities of a series of chlorophenyloxyalkoxy and chlorophenalkoxy n-substituted diamino-dihydrotriazines were determined in vitro against three strains of plasmodium falciparum ( malayan camp , vietnam smith , fcb ) with diverse levels of resistance to chloroquine , pyrimethamine , and cycloguanil . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial",
"pos": [
4,
16
]
} | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
273,
284
]
} |
the effects of an antiarrhythmic and antianginal drug , amiodarone , on the physical state of membrane phospholipids was investigated by means of fluorescence polarization using the apolar probe 1,6 diphenyl-1,3,5-hexatriene incorporated in the hydrocarbon core . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
18,
32
]
} | {
"id": "C0002598",
"name": "amiodarone",
"pos": [
56,
66
]
} |
the present report describes the effects of the neuroleptic pimozide on the reinforcing efficacy of central grey stimulation . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
48,
59
]
} | {
"id": "C0031935",
"name": "pimozide",
"pos": [
60,
68
]
} |
chronic administration of the neuroleptic haloperidol , the calcium channel antagonist nitrendipine , and the calcium channel antagonist neuroleptic pimozide produce differential effects on rat striatal 3h-spiperone binding . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
30,
41
]
} | {
"id": "C0031935",
"name": "pimozide",
"pos": [
149,
157
]
} |
the influence of two neuroleptics -- the phenothiazine perazine and the butyrophenone haloperidol -- on the metabolism of the tricyclic antidepressants amitriptyline ( ami ) , imipramine ( imi ) , and chlorimipramine ( cmi ) was studied in vitro in isolated liver microsomes of female sprague-dawley rats . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
21,
33
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
86,
97
]
} |
erythromycin antimicrobial prophylaxis for children with recurrent otitis media was superior to no prophylaxis and to sulfisoxazole prophylaxis in this study of patients with recurrent otitis media without persistent middle ear effusion . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial",
"pos": [
13,
26
]
} | {
"id": "C0038745",
"name": "sulfisoxazole",
"pos": [
118,
131
]
} |
effect of 5-fluorouracil , mitoxantrone , methotrexate , and vincristine on the antibacterial activity of ceftriaxone , ceftazidime , cefotiam , piperacillin , and netilmicin . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
80,
93
]
} | {
"id": "C0007561",
"name": "ceftriaxone",
"pos": [
106,
117
]
} |
effect of 5-fluorouracil , mitoxantrone , methotrexate , and vincristine on the antibacterial activity of ceftriaxone , ceftazidime , cefotiam , piperacillin , and netilmicin . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
80,
93
]
} | {
"id": "C0007559",
"name": "ceftazidime",
"pos": [
120,
131
]
} |
effect of 5-fluorouracil , mitoxantrone , methotrexate , and vincristine on the antibacterial activity of ceftriaxone , ceftazidime , cefotiam , piperacillin , and netilmicin . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
80,
93
]
} | {
"id": "C0031955",
"name": "piperacillin",
"pos": [
145,
157
]
} |
effect of 5-fluorouracil , mitoxantrone , methotrexate , and vincristine on the antibacterial activity of ceftriaxone , ceftazidime , cefotiam , piperacillin , and netilmicin . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
80,
93
]
} | {
"id": "C0027780",
"name": "netilmicin",
"pos": [
164,
174
]
} |
antidepressants with a low incidence of annoying adverse reactions ( e.g. , desipramine ) may be used as initial drug therapy in patients with concomitant depression . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
0,
15
]
} | {
"id": "C0011685",
"name": "desipramine",
"pos": [
76,
87
]
} |
lamotrigine ( ltg ) [ 3,5-diamino-6- ( 2,3-dichlorophenyl ) -1,2,4-triazine ] is a novel anticonvulsant chemically unrelated to current antiepileptic drugs and with a pharmacological profile similar to that of phenytoin . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic",
"pos": [
136,
149
]
} | {
"id": "C0031507",
"name": "phenytoin",
"pos": [
210,
219
]
} |
free , total , and short-chain acylcarnitine were measured in the serum of 21 pediatric patients receiving vpa therapy , 21 healthy matched controls , and 21 patients receiving various antiepileptic drugs other than vpa . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drugs",
"pos": [
185,
204
]
} | {
"id": "C0042291",
"name": "vpa",
"pos": [
216,
219
]
} |
a number of neuroleptic drugs , such as haloperidol , chlorpromazine , perphenazine and trifluperidol reduced grooming more effectively than burying . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
12,
23
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
40,
51
]
} |
the effects of single and long-term administration of the antidepressants imipramine , desimipramine , amitriptyline , zimelidine and maprotiline were studied in the rabbit brain . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
58,
73
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
90,
100
]
} |
the effects of single and long-term administration of the antidepressants imipramine , desimipramine , amitriptyline , zimelidine and maprotiline were studied in the rabbit brain . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
58,
73
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
103,
116
]
} |
the antibacterial activity of 5-fluorouracil , an antineoplastic agent , was found to be enhanced by piperacillin , a beta-lactam antibiotic , resulting in a synergism . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0031955",
"name": "piperacillin",
"pos": [
101,
113
]
} |
the antifungal drug ketoconazole is known to inhibit testosterone biosynthesis and decrease serum testosterone concentrations . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal drug",
"pos": [
4,
19
]
} | {
"id": "C0022625",
"name": "ketoconazole",
"pos": [
20,
32
]
} |
electrophysiologic and antiarrhythmic efficacy of oral sotalol for sustained ventricular tachyarrhythmias : evaluation by programmed stimulation and ambulatory electrocardiogram . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
23,
37
]
} | {
"id": "C0037707",
"name": "sotalol",
"pos": [
55,
62
]
} |
this compound had antiviral activity equivalent to that of tft against hsv-1 in a plaque reduction assay ( id 50 = 0.5-1.0 microgram/ml ) , either directly or by conversion to tft . | therapeutic_class_of | {
"id": "C0003451",
"name": "antiviral",
"pos": [
18,
27
]
} | {
"id": "C0040987",
"name": "tft",
"pos": [
176,
179
]
} |
as compared to their conceptual parents , these agents retained a considerable amount of the antimicrobial potency and spectra of ciprofloxacin and of 6-fluoro-1-phenyl-7- ( 1-piperazinyl ) -1,4-dihydro-4-oxoquinoline-3-carboxy lic acid against gram-positives . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial",
"pos": [
93,
106
]
} | {
"id": "C0008809",
"name": "ciprofloxacin",
"pos": [
130,
143
]
} |
antibacterial activities of imipenem ( mk-0787 ) , cefazolin ( cez ) , cefmenoxime ( cmx ) and cefoperazone ( cpz ) were measured by using an agar dilution method against 243 strains of bacteria isolated from the patients with urinary tract infections . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
0,
13
]
} | {
"id": "C0020933",
"name": "imipenem",
"pos": [
28,
36
]
} |
antibacterial activities of imipenem ( mk-0787 ) , cefazolin ( cez ) , cefmenoxime ( cmx ) and cefoperazone ( cpz ) were measured by using an agar dilution method against 243 strains of bacteria isolated from the patients with urinary tract infections . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
0,
13
]
} | {
"id": "C0007546",
"name": "cefazolin",
"pos": [
51,
60
]
} |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.