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the antiarrhythmic potentiation that occurs with the coadministration of quinidine-propranolol has been attributed to propranolol-induced cardiac beta adrenergic receptor blockade . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
4,
18
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
73,
82
]
} |
the effects of the antidepressant drug desipramine ( dmi ) on the density of beta-adrenoceptor sites were studied on intact cultured human cells : skin fibroblasts , lung fibroblasts and macrophages . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
19,
33
]
} | {
"id": "C0011685",
"name": "desipramine",
"pos": [
39,
50
]
} |
the in vitro activity of the quinolone derivative flumequine against 1918 bacterial strains , isolated from urinary tract infections , has been compared to the antibacterial activity of other compounds , such as pipemidic acid , oxolinic acid and cefazolin . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
160,
173
]
} | {
"id": "C0007546",
"name": "cefazolin",
"pos": [
247,
256
]
} |
the antiarrhythmic drugs elute in the k ' ( capacity factor ) range of 1.43 ( lidocaine ) to 5.7 ( disopyramide ) . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drugs",
"pos": [
4,
24
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
78,
87
]
} |
the antiarrhythmic drugs elute in the k ' ( capacity factor ) range of 1.43 ( lidocaine ) to 5.7 ( disopyramide ) . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drugs",
"pos": [
4,
24
]
} | {
"id": "C0012702",
"name": "disopyramide",
"pos": [
99,
111
]
} |
when compared with other antifungals , ketoconazole seems to be superior to nystatin and as effective as amphotericin b ( 500 mg t.i.d . ) . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungals",
"pos": [
25,
36
]
} | {
"id": "C0022625",
"name": "ketoconazole",
"pos": [
39,
51
]
} |
when compared with other antifungals , ketoconazole seems to be superior to nystatin and as effective as amphotericin b ( 500 mg t.i.d . ) . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungals",
"pos": [
25,
36
]
} | {
"id": "C0002679",
"name": "amphotericin b",
"pos": [
105,
119
]
} |
combined treatment of mice with bha and enteric antimicrobial agents reduced the levels of mutagens derived from metronidazole by more than 90 % , and the combined treatments were more effective than was either treatment alone . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial agents",
"pos": [
48,
68
]
} | {
"id": "C0025872",
"name": "metronidazole",
"pos": [
113,
126
]
} |
clomipramine , a new antidepressant , differs from imipramine by having chlorine in position 3 of the aromatic ring and in this respect resembles chlorpromazine . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
21,
35
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
51,
61
]
} |
differential absorptiometric ph titrations of the antimalarials chloroquine and quinacrine , employing the respective uncharged species at ph 12.5 in the reference cell , show that protolytic dissociation from the heterocyclic ring nitrogen atoms occurs over ph 6 -- 12 . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarials",
"pos": [
50,
63
]
} | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
64,
75
]
} |
many of the thioquinazolines ( viii ) showed suppressive antimalarial activity comparable with or superior to chloroquine , cycloguanil , and pyrimethamine against drug-sensitive lines of plasmodium berghei in mice and plasmodium gallinaceum in chicks , and several displayed potent prophylactic activity with p. gallinaceum . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial",
"pos": [
57,
69
]
} | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
110,
121
]
} |
in antifungal bioassays a number of compounds display in vitro and , in a few cases , in vivo activities comparable to that of miconazole . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
3,
13
]
} | {
"id": "C0025942",
"name": "miconazole",
"pos": [
127,
137
]
} |
the microtrays were found to be reliable for all antimicrobials tested ( benzylpenicillin , clindamycin , doxycycline , chloramphenicol , fusidic acid , cefoxitin , and cephalotin ) but not for metronidazole . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobials",
"pos": [
49,
63
]
} | {
"id": "C0025872",
"name": "metronidazole",
"pos": [
194,
207
]
} |
pretreatment with neuroleptics ( pimozide , haloperidol , and chlorpromazine ) , but not with propranolol , phenoxybenzamine , alpha-methyl-para-tyrosine , or physostigmine , attenuated the cocaine discrimination . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
18,
30
]
} | {
"id": "C0031935",
"name": "pimozide",
"pos": [
33,
41
]
} |
pretreatment with neuroleptics ( pimozide , haloperidol , and chlorpromazine ) , but not with propranolol , phenoxybenzamine , alpha-methyl-para-tyrosine , or physostigmine , attenuated the cocaine discrimination . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
18,
30
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
44,
55
]
} |
ninety young children with otitis media , proven by tympanocentesis culture to be due to hemophilus influenzae , were treated in a prospective double-blind study with one of three antimicrobial regimens : ampicillin , erythromycin ethylsuccinate , or erythromycin ethylsuccinate with concomitant trisulfapyrimidines . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial",
"pos": [
180,
193
]
} | {
"id": "C0014810",
"name": "erythromycin ethylsuccinate",
"pos": [
251,
278
]
} |
[ the effect of the new antiarrhythmic drug mexiletine on sinus node and intracardiac conduction in man ( author 's transl ) ] . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
24,
38
]
} | {
"id": "C0025887",
"name": "mexiletine",
"pos": [
44,
54
]
} |
the 3h-leucine incorporation in proteins of incretory organs of the mouse , the exocrine pancreas , and the renal tubuli was studied autoradiographically after administration of therapylike doses of the neuroleptic drug haloperidol . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
203,
214
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
220,
231
]
} |
midway through the procedure one group was treated with the antidepressant imipramine hydrochloride , the other with a saline placebo . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
60,
74
]
} | {
"id": "C0589978",
"name": "imipramine hydrochloride",
"pos": [
75,
99
]
} |
1 serum , urine and pharmacologic effect ( prolongation of the qt interval ) kinetics of the antiarrhythmic disopyramide have been investigated in eight volunteers after intravenous administration ( 2 mg/kg ) and oral administration ( 300 mg ) of the two commercially available preparations , rythmodan ( roussel laboratories ) and norpace ( searle laboratories ) . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
93,
107
]
} | {
"id": "C0012702",
"name": "disopyramide",
"pos": [
108,
120
]
} |
antibacterial activity in serum and urine following oral administration in man of dl473 ( a cyclopentyl derivative of rifampicin ) [ proceedings ] . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
0,
13
]
} | {
"id": "C0035608",
"name": "rifampicin",
"pos": [
118,
128
]
} |
lipophilic substances ( i.e . the antiepileptic drugs diphenylhydantoin , primidone and phenobarbital ) are then extracted into 20 ml of ether and the solvent is evaporated to dryness . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drugs",
"pos": [
34,
53
]
} | {
"id": "C0031507",
"name": "diphenylhydantoin",
"pos": [
54,
71
]
} |
lipophilic substances ( i.e . the antiepileptic drugs diphenylhydantoin , primidone and phenobarbital ) are then extracted into 20 ml of ether and the solvent is evaporated to dryness . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drugs",
"pos": [
34,
53
]
} | {
"id": "C0033148",
"name": "primidone",
"pos": [
74,
83
]
} |
tocainide is a new antiarrhythmic drug with a chemical structure related to that of lidocaine . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drug",
"pos": [
19,
38
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
84,
93
]
} |
the susceptibility of s. johannesburg strains isolated in a 5-year period from 1973 to 1977 to eight antimicrobial drugs including ampicillin ( a ) , streptomycin ( s ) , tetracycline ( t ) , chloramphenicol ( c ) , kanamycin ( k ) , sulphadiazine ( su ) , trimethoprim ( tm ) and gentamicin ( g ) was tested by the agar dilution method . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial drugs",
"pos": [
101,
120
]
} | {
"id": "C0039644",
"name": "tetracycline",
"pos": [
171,
183
]
} |
observations on the effects of selected antiarrhythmic drugs on mammalian cardiac purkinje fibers with two levels of steady-state potential : influences of lidocaine , phenytoin , propranolol , disopyramide and procainamide on repolarization , action potential shape and conduction . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
40,
54
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
156,
165
]
} |
observations on the effects of selected antiarrhythmic drugs on mammalian cardiac purkinje fibers with two levels of steady-state potential : influences of lidocaine , phenytoin , propranolol , disopyramide and procainamide on repolarization , action potential shape and conduction . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
40,
54
]
} | {
"id": "C0012702",
"name": "disopyramide",
"pos": [
194,
206
]
} |
observations on the effects of selected antiarrhythmic drugs on mammalian cardiac purkinje fibers with two levels of steady-state potential : influences of lidocaine , phenytoin , propranolol , disopyramide and procainamide on repolarization , action potential shape and conduction . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
40,
54
]
} | {
"id": "C0033216",
"name": "procainamide",
"pos": [
211,
223
]
} |
the five basic antirheumatic drugs : antimalarials , immunosuppressive agents , gold salts , penicillamine and levamisole induce side effects in a large number of patients . | therapeutic_class_of | {
"id": "C0003191",
"name": "antirheumatic drugs",
"pos": [
15,
34
]
} | {
"id": "C0030817",
"name": "penicillamine",
"pos": [
93,
106
]
} |
the adsorption of the antiepileptics sulthiame , phenytoin , mephenytoin , mesuximide , phensuximide , ethosuximide , and primidone on various antacids or adsorbents was studied at 37 degrees c . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptics",
"pos": [
22,
36
]
} | {
"id": "C0031507",
"name": "phenytoin",
"pos": [
63,
72
]
} |
the adsorption of the antiepileptics sulthiame , phenytoin , mephenytoin , mesuximide , phensuximide , ethosuximide , and primidone on various antacids or adsorbents was studied at 37 degrees c . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptics",
"pos": [
22,
36
]
} | {
"id": "C0025381",
"name": "mephenytoin",
"pos": [
61,
72
]
} |
the adsorption of the antiepileptics sulthiame , phenytoin , mephenytoin , mesuximide , phensuximide , ethosuximide , and primidone on various antacids or adsorbents was studied at 37 degrees c . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptics",
"pos": [
22,
36
]
} | {
"id": "C0015043",
"name": "ethosuximide",
"pos": [
103,
115
]
} |
the adsorption of the antiepileptics sulthiame , phenytoin , mephenytoin , mesuximide , phensuximide , ethosuximide , and primidone on various antacids or adsorbents was studied at 37 degrees c . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptics",
"pos": [
22,
36
]
} | {
"id": "C0033148",
"name": "primidone",
"pos": [
122,
131
]
} |
eleven healthy volunteers ( mean age 30.1 +/- 4.3 yrs . ) were repeatedly studied by measurement of systolic time intervals ( qs2c , pepc , lvetc , pep/lvet ) and arterial blood pressure ( cuff method ) before and after 24-hour oral application of four antiarrhythmic drugs ( quinidine , disopyramide , prajmaliumbitartrate , propafenone ) and two beta-blocking agents ( propranolol , atenolol ) . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drugs",
"pos": [
253,
273
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
276,
285
]
} |
eleven healthy volunteers ( mean age 30.1 +/- 4.3 yrs . ) were repeatedly studied by measurement of systolic time intervals ( qs2c , pepc , lvetc , pep/lvet ) and arterial blood pressure ( cuff method ) before and after 24-hour oral application of four antiarrhythmic drugs ( quinidine , disopyramide , prajmaliumbitartrate , propafenone ) and two beta-blocking agents ( propranolol , atenolol ) . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drugs",
"pos": [
253,
273
]
} | {
"id": "C0012702",
"name": "disopyramide",
"pos": [
288,
300
]
} |
eleven healthy volunteers ( mean age 30.1 +/- 4.3 yrs . ) were repeatedly studied by measurement of systolic time intervals ( qs2c , pepc , lvetc , pep/lvet ) and arterial blood pressure ( cuff method ) before and after 24-hour oral application of four antiarrhythmic drugs ( quinidine , disopyramide , prajmaliumbitartrate , propafenone ) and two beta-blocking agents ( propranolol , atenolol ) . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drugs",
"pos": [
253,
273
]
} | {
"id": "C0033429",
"name": "propafenone",
"pos": [
326,
337
]
} |
the results clearly indicate that at the dosage used , the four antiarrhythmic agents ( quinidine , disopyramide , prajmaliumbitartrate , propafenone ) exert a negative inotropic effect on left ventricular function as far as it can be judged from the measurement of sti . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agents",
"pos": [
64,
85
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
88,
97
]
} |
the results clearly indicate that at the dosage used , the four antiarrhythmic agents ( quinidine , disopyramide , prajmaliumbitartrate , propafenone ) exert a negative inotropic effect on left ventricular function as far as it can be judged from the measurement of sti . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agents",
"pos": [
64,
85
]
} | {
"id": "C0012702",
"name": "disopyramide",
"pos": [
100,
112
]
} |
the results clearly indicate that at the dosage used , the four antiarrhythmic agents ( quinidine , disopyramide , prajmaliumbitartrate , propafenone ) exert a negative inotropic effect on left ventricular function as far as it can be judged from the measurement of sti . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agents",
"pos": [
64,
85
]
} | {
"id": "C0033429",
"name": "propafenone",
"pos": [
138,
149
]
} |
the in vitro antifungal activities of two n-aminoacyl derivatives of amphotericin b methyl ester ( ame ) were compared by tube dilution with those of amphotericin b and ame , using 60 isolates representing 10 yeast species . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
13,
23
]
} | {
"id": "C0002679",
"name": "amphotericin b",
"pos": [
150,
164
]
} |
a neutralizer system was developed and validated for use in the in vitro bactericidal evaluation of three commonly used antiseptics , namely , hibiclens ( 4 % [ wt/vol ] chlorhexidine gluconate ) , betadine ( 7.5 % [ wt/vol ] povidone-iodine ) , and phisohex ( 3 % [ wt/vol ] hexachlorophene ) . | therapeutic_class_of | {
"id": "C0003205",
"name": "antiseptics",
"pos": [
120,
131
]
} | {
"id": "C0032857",
"name": "povidone-iodine",
"pos": [
226,
241
]
} |
a neutralizer system was developed and validated for use in the in vitro bactericidal evaluation of three commonly used antiseptics , namely , hibiclens ( 4 % [ wt/vol ] chlorhexidine gluconate ) , betadine ( 7.5 % [ wt/vol ] povidone-iodine ) , and phisohex ( 3 % [ wt/vol ] hexachlorophene ) . | therapeutic_class_of | {
"id": "C0003205",
"name": "antiseptics",
"pos": [
120,
131
]
} | {
"id": "C0019435",
"name": "hexachlorophene",
"pos": [
276,
291
]
} |
general pharmacological properties of 4'-fluoro-4- [ 4- ( 2-thioxo-1-benzimidazolinyl ) piperidino ] butyrophenone ( timiperone ) , a new neuroleptic drug , were compared with those of haloperidol . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic drug",
"pos": [
138,
154
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
185,
196
]
} |
the antibacterial activity of cefoxitin and cephalothin was tested against 7,312 clinical isolates of aerobic pathogens . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0007557",
"name": "cefoxitin",
"pos": [
30,
39
]
} |
3 patients with atrial fibrillation , of varying origin , have been successfully converted to sinus rhythm by d.c. shock while on the antiarrhythmic drug amiodarone . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drug",
"pos": [
134,
153
]
} | {
"id": "C0002598",
"name": "amiodarone",
"pos": [
154,
164
]
} |
both antidepressants antagonised the mydriasis evoked by methoxamine , amitriptyline being approximately twice as potent as desipramine . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
5,
20
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
71,
84
]
} |
both antidepressants antagonised the mydriasis evoked by methoxamine , amitriptyline being approximately twice as potent as desipramine . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
5,
20
]
} | {
"id": "C0011685",
"name": "desipramine",
"pos": [
124,
135
]
} |
it is argued that the interaction of the antidepressants with adrenergic mechanisms could explain why amitriptyline , a potent anticholinergic agent , causes no significant change in resting pupil diameter , while desipramine , a relatively weaker anticholinergic agent , produces a significant mydriasis . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
41,
56
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
102,
115
]
} |
it is argued that the interaction of the antidepressants with adrenergic mechanisms could explain why amitriptyline , a potent anticholinergic agent , causes no significant change in resting pupil diameter , while desipramine , a relatively weaker anticholinergic agent , produces a significant mydriasis . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
41,
56
]
} | {
"id": "C0011685",
"name": "desipramine",
"pos": [
214,
225
]
} |
the antibacterial activity of the 7-aca derivative was comparable to cephalothin , and that of the other two derivatives was comparable to cefazolin . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0007546",
"name": "cefazolin",
"pos": [
139,
148
]
} |
n-formimidoyl thienamycin ( mk0787 ) : in-vitro antibacterial activity and susceptibility to beta-lactamases compared with that of cefotaxime , moxalactam and other beta-lactam antibiotics . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
48,
61
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
131,
141
]
} |
if this be the case , then antimicrobial therapy directed against these anaerobes wih metronidazole was indicated . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial",
"pos": [
27,
40
]
} | {
"id": "C0025872",
"name": "metronidazole",
"pos": [
86,
99
]
} |
this study suggests an antidepressant effect of bromocriptine although , due to the possibility of type ii error , it may not necessarily be equal to that of imipramine . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
23,
37
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
158,
168
]
} |
antiarrhythmic agents , lidocaine , dl-propranolol or verapamil , did not cause a significant change in plasma digoxin concentration in the anesthetized guinea pigs . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agents",
"pos": [
0,
21
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
24,
33
]
} |
additionally , of the four antiarrhythmic drugs , quinidine appears to be the only agent which interacts with digoxin . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drugs",
"pos": [
27,
47
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
50,
59
]
} |
considering from its superior antibacterial activity , cefadroxil may be expected to be useful for a remedy in slight or middle infections of children . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
30,
43
]
} | {
"id": "C0007538",
"name": "cefadroxil",
"pos": [
55,
65
]
} |
the antiarrhythmic efficacy and safety of oral flecainide acetate were assessed during a controlled , short-term dosage-maintenance study . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
4,
18
]
} | {
"id": "C0086303",
"name": "flecainide acetate",
"pos": [
47,
65
]
} |
effects of antidepressant treatment with clomipramine on hormonal responses to thyrotropin-releasing hormone and insulin-induced hypoglycemia : implications for the `` '' monoamine-hypothesis '' '' . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
11,
25
]
} | {
"id": "C0009010",
"name": "clomipramine",
"pos": [
41,
53
]
} |
the findings suggest that the neuroendocrine and antidepressant effects of clomipramine can not be accounted for entirely on the basis of monoaminergic mechanisms . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
49,
63
]
} | {
"id": "C0009010",
"name": "clomipramine",
"pos": [
75,
87
]
} |
the anthelmintics dichlorvos , levamisole and mebendazole produced a marked improvement in daily growth and reduced the degree to which the liver was involved . | therapeutic_class_of | {
"id": "C0003158",
"name": "anthelmintics",
"pos": [
4,
17
]
} | {
"id": "C0025023",
"name": "mebendazole",
"pos": [
46,
57
]
} |
eight antibacterial agents , cephalothin , colistin , doxycycline , erythromycin , gentamicin , chloramphenicol , oxytetracycline and trimethoprim were studied in a phagocytic system using human polymorphonuclear cells ( pmn ) and a radio-labelled strain of escherichia coli as test microbe . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial agents",
"pos": [
6,
26
]
} | {
"id": "C0008168",
"name": "chloramphenicol",
"pos": [
96,
111
]
} |
eight antibacterial agents , cephalothin , colistin , doxycycline , erythromycin , gentamicin , chloramphenicol , oxytetracycline and trimethoprim were studied in a phagocytic system using human polymorphonuclear cells ( pmn ) and a radio-labelled strain of escherichia coli as test microbe . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial agents",
"pos": [
6,
26
]
} | {
"id": "C0041041",
"name": "trimethoprim",
"pos": [
134,
146
]
} |
effects of two antirheumatic drugs , d-penicillamine and ( - ) -2,3,5,6-tetrahydro-6-phenylimidazo [ 2,1-b ] thiazole ( levamisole ) , on some human serum proteins with specific function are reported . | therapeutic_class_of | {
"id": "C0003191",
"name": "antirheumatic",
"pos": [
15,
28
]
} | {
"id": "C0030817",
"name": "penicillamine",
"pos": [
39,
52
]
} |
antibacterial activity of moxalactam ( ly-127935 ) compared with cefotaxime and other beta-lactam antibiotics against clinical isolates of enterobacteriacea and non-fermenters . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
0,
13
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
65,
75
]
} |
neuroleptics , particularly haloperidol and perphenazine , inhibit the activity of brain ca , mg-atpase to a greater extent than the antidepressants benactizin and amphetamine . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
0,
12
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
28,
39
]
} |
1 the action of five neuroleptic drugs ( haloperidol , cis-flupenthixol , chlorpromazine , fluphenazine and thioridazine ) was studied on the synthesis and release of dopamine from rat striatal synaptosomes . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic drugs",
"pos": [
21,
38
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
41,
52
]
} |
the following antiepileptic drugs were tested for anticonvulsant activity in mice lesioned with ka : diazepam ( 0.4 mg/kg ) , phenobarbital ( 12.5 and 25 mg/kg ) , trimethadione ( 200 and 400 mg/kg ) , depakine ( 200 and 400 mg/kg ) , carbamazepine ( 10 and 20 mg/kg ) , lefadol ( bromophenylsuccinimide ; 20 mg/kg ) , and acetazolamide ( 320 mg/kg ) . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drugs",
"pos": [
14,
33
]
} | {
"id": "C0041038",
"name": "trimethadione",
"pos": [
164,
177
]
} |
pretreatment of the rat phrenic nerve-diaphragm preparation with the sulfhydryl- ( sh ) blocking agent p-hydroxymercuribenzoate ( pohmb ) increased the blocking efficiency of the antiepileptic drug diphenylhydantoin ( dph ) during indirect stimulation . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic",
"pos": [
179,
192
]
} | {
"id": "C0031507",
"name": "diphenylhydantoin",
"pos": [
198,
215
]
} |
study of 16 antidepressants , ( imipramine , amitryptyline , doxepin , dibenzepin , maprotilin , mianserin , nomifensin , trazodon , caroxazon , adepren , viloxazin , nialamid , asaphen , pyrazidol , inkasan , ftoracizin ) in experiments on white mice have shown that the drugs tested may be arranged in the following way as regards the intensity of the mydriatic effect they produce : ftoracizin , amitryptyline , doxepin , imipramine , dibenzepin . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
12,
27
]
} | {
"id": "C0002600",
"name": "amitryptyline",
"pos": [
399,
412
]
} |
study of 16 antidepressants , ( imipramine , amitryptyline , doxepin , dibenzepin , maprotilin , mianserin , nomifensin , trazodon , caroxazon , adepren , viloxazin , nialamid , asaphen , pyrazidol , inkasan , ftoracizin ) in experiments on white mice have shown that the drugs tested may be arranged in the following way as regards the intensity of the mydriatic effect they produce : ftoracizin , amitryptyline , doxepin , imipramine , dibenzepin . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
12,
27
]
} | {
"id": "C0013085",
"name": "doxepin",
"pos": [
415,
422
]
} |
study of 16 antidepressants , ( imipramine , amitryptyline , doxepin , dibenzepin , maprotilin , mianserin , nomifensin , trazodon , caroxazon , adepren , viloxazin , nialamid , asaphen , pyrazidol , inkasan , ftoracizin ) in experiments on white mice have shown that the drugs tested may be arranged in the following way as regards the intensity of the mydriatic effect they produce : ftoracizin , amitryptyline , doxepin , imipramine , dibenzepin . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
12,
27
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
425,
435
]
} |
[ on the hazards of an exaggerated fear of drugs in pregnancy . studies on the influence of hyperemesis gravidarum as well as various antiemetics ( meclizine , phenothiazine derivatives ) on the incidence of malformations ] . | therapeutic_class_of | {
"id": "C0003297",
"name": "antiemetics",
"pos": [
134,
145
]
} | {
"id": "C0025039",
"name": "meclizine",
"pos": [
148,
157
]
} |
antagonism of the antimalarial action of chloroquine by ferrihemate and an hypothesis for the mechanism of chloroquine resistance . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial",
"pos": [
18,
30
]
} | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
107,
118
]
} |
these opposite psychopharmacological effects are consistent with the different clinical effects of these drugs and suggest a mechanism for the antidepressive action of imipramine . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressive",
"pos": [
143,
157
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
168,
178
]
} |
[ the simultaneous action of two or more antimicrobial substances ; the antibacterial action of a penicillin-streptomycin-chloramphenicol combination on haemophilus influenzae in vitro ] . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
72,
85
]
} | {
"id": "C0038425",
"name": "streptomycin",
"pos": [
109,
121
]
} |
[ the simultaneous action of two or more antimicrobial substances ; the antibacterial action of a penicillin-streptomycin-chloramphenicol combination on haemophilus influenzae in vitro ] . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
72,
85
]
} | {
"id": "C0008168",
"name": "chloramphenicol",
"pos": [
122,
137
]
} |
the microassay technique has been standardized in buffer solutions and in normal human serum pools for the following antimicrobials : ampicillin , methicillin , penicillin g , oxacillin , cloxacillin , dicloxacillin , cephaloglycin , cephalexin , cephaloridine , cephalothin , erythromycin , rifamycin amino methyl piperazine , kanamycin , neomycin , streptomycin , colistin , polymyxin b , doxycycline , minocycline , oxytetracycline , tetracycline , and chloramphenicol . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobials",
"pos": [
117,
131
]
} | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
277,
289
]
} |
the microassay technique has been standardized in buffer solutions and in normal human serum pools for the following antimicrobials : ampicillin , methicillin , penicillin g , oxacillin , cloxacillin , dicloxacillin , cephaloglycin , cephalexin , cephaloridine , cephalothin , erythromycin , rifamycin amino methyl piperazine , kanamycin , neomycin , streptomycin , colistin , polymyxin b , doxycycline , minocycline , oxytetracycline , tetracycline , and chloramphenicol . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobials",
"pos": [
117,
131
]
} | {
"id": "C0030092",
"name": "oxytetracycline",
"pos": [
419,
434
]
} |
the microassay technique has been standardized in buffer solutions and in normal human serum pools for the following antimicrobials : ampicillin , methicillin , penicillin g , oxacillin , cloxacillin , dicloxacillin , cephaloglycin , cephalexin , cephaloridine , cephalothin , erythromycin , rifamycin amino methyl piperazine , kanamycin , neomycin , streptomycin , colistin , polymyxin b , doxycycline , minocycline , oxytetracycline , tetracycline , and chloramphenicol . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobials",
"pos": [
117,
131
]
} | {
"id": "C0039644",
"name": "tetracycline",
"pos": [
437,
449
]
} |
[ comparison of antibacterial effect of rifampicin and cephaloridine on a model of e. coli pyelonephritis in rats ] . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
16,
29
]
} | {
"id": "C0035608",
"name": "rifampicin",
"pos": [
40,
50
]
} |
the in vivo effect of folinic acid ( citrovorum factor ) on the potentiation of the antibacterial activity of sulfisoxazole by trimethoprim . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
84,
97
]
} | {
"id": "C0041041",
"name": "trimethoprim",
"pos": [
127,
139
]
} |
the in-vitro antibacterial activities of erythromycin , lincomycin , and clindamycin , a new derivative of lincomycin , were compared . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
13,
26
]
} | {
"id": "C0008947",
"name": "clindamycin",
"pos": [
73,
84
]
} |
[ experimental studies on an antimalarial preparation haloquine ( cycloquine ) . i. comparative studies on the hematoschizotropic activity of haloquine and chloroquine administered in various doses ] . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial",
"pos": [
29,
41
]
} | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
156,
167
]
} |
the antidotal potency of a cobalt salt ( acetate ) , of dicobalt edetate , of hydroxocobalamin and of cobinamide against hydrocyanic acid was examined mainly on mice and rabbits . | therapeutic_class_of | {
"id": "C0003295",
"name": "antidotal",
"pos": [
4,
13
]
} | {
"id": "C0020316",
"name": "hydroxocobalamin",
"pos": [
78,
94
]
} |
[ first results of the treatment of 60 cases of mental disorders with a new neuroleptic agent , haloperidol ( r 1625 ) ] . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic agent",
"pos": [
76,
93
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
96,
107
]
} |
inability to achieve adequate antibacterial activity in human blood serum after intravenous administration of nitrofurantoin . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
30,
43
]
} | {
"id": "C0028156",
"name": "nitrofurantoin",
"pos": [
110,
124
]
} |
in order to achieve a more differentiated assessment of the profile and time course of treatment with a new antidepressant drug , several psychiatric , neurophysiological , and biochemical parameters were examined in a double-blind study ( viloxazine versus amitriptyline ) . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant drug",
"pos": [
108,
127
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
258,
271
]
} |
[ evaluation of an antiseptic method for the surgical field in a group of heart surgery patients using a produce based on povidone iodine . preliminary report ] . | therapeutic_class_of | {
"id": "C0003205",
"name": "antiseptic",
"pos": [
19,
29
]
} | {
"id": "C0032857",
"name": "povidone iodine",
"pos": [
122,
137
]
} |
the substance was found to possess antidepressant , drive-promoting properties which correspond to amitriptyline in their intensity or are superior even . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
35,
49
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
99,
112
]
} |
the response pattern of the autonomic nervous system was investigated after central administration ( intra-cisternal , vertebral artery ) of amphetamine , morphine , fentanyl , dextromoramide and the substance r 28935 , chemically related to the neuroleptic agent pimozide . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic agent",
"pos": [
246,
263
]
} | {
"id": "C0031935",
"name": "pimozide",
"pos": [
264,
272
]
} |
antimicrobial and toxicological studies on an antiseptic based on hexachlorophene and destructive distillate of castor oil . | therapeutic_class_of | {
"id": "C0003205",
"name": "antiseptic",
"pos": [
46,
56
]
} | {
"id": "C0019435",
"name": "hexachlorophene",
"pos": [
66,
81
]
} |
in the group of successfully treated arrhythmic cats as well as in normal animals , the drug increased the blood pressure , while the equally effective antiarrhythmic drug , lidocaine , did decrease blood pressure . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drug",
"pos": [
152,
171
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
174,
183
]
} |
the in vitro antibacterial activity of piperacillin and cefuroxime against 180 isolates of cephalothin-resistant enterobacteriaceae and of piperacillin against 46 isolates of pseudomonas aeruginosa was determined . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
13,
26
]
} | {
"id": "C0007562",
"name": "cefuroxime",
"pos": [
56,
66
]
} |
the in vitro antibacterial activity of piperacillin and cefuroxime against 180 isolates of cephalothin-resistant enterobacteriaceae and of piperacillin against 46 isolates of pseudomonas aeruginosa was determined . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
13,
26
]
} | {
"id": "C0031955",
"name": "piperacillin",
"pos": [
139,
151
]
} |
the antimalarial action of primaquine against the blood and tissue stages of falciparum malaria ( panama , p-f-6 strain ) . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial",
"pos": [
4,
16
]
} | {
"id": "C0033126",
"name": "primaquine",
"pos": [
27,
37
]
} |
the effects of this new antiarrhythmic agent were similar to procainamide in this drug-resistant study population . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agent",
"pos": [
24,
44
]
} | {
"id": "C0033216",
"name": "procainamide",
"pos": [
61,
73
]
} |
of 25 patients previously treated with phenytoin , in whom alternative antiarrhythmic therapy was required , 40 % had long-term arrhythmia control when treated with mexiletine . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
71,
85
]
} | {
"id": "C0025887",
"name": "mexiletine",
"pos": [
165,
175
]
} |
all compounds synthesized were evaluated for their antiarrhythmic activities using the chloroform-mouse method , and some of them were found to have significant antiarrhythmic activities , comparable to that of procainamide . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
51,
65
]
} | {
"id": "C0033216",
"name": "procainamide",
"pos": [
211,
223
]
} |
the antimicrobial combination of trimethoprim and sulfamethoxazole is active in vitro against a variety of gram-positive and gram-negative bacteria . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial",
"pos": [
4,
17
]
} | {
"id": "C0038689",
"name": "sulfamethoxazole",
"pos": [
50,
66
]
} |
the present paper gives a survey about topographic analyses of pharmaco-eeg data obtained in systematic double-blind , placebo-controlled studies in normal healthy volunteers involving representative drugs of 5 different psychopharmacological classes , such as neuroleptics ( chlorprothixene ) , antidepressants ( imipramine ) , tranquilizers ( diazepam ) , psychostimulants ( caffeine ) , and antihypoxidotics/nootropics ( pyritinol ) . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
296,
311
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
314,
324
]
} |
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