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these actions were a consequence of dopaminergic activation since they were antagonized by pretreatment with the neuroleptic agent , pimozide . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic agent",
"pos": [
113,
130
]
} | {
"id": "C0031935",
"name": "pimozide",
"pos": [
133,
141
]
} |
however , the long-term administration of neuroleptic drugs to rodents shows that typical neuroleptic drugs can induce functional supersensitivity of dopamine receptors despite continued administration of drug . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
42,
53
]
} | {
"id": "C2917392",
"name": "typical neuroleptic",
"pos": [
82,
101
]
} |
in addition , the intraventricular administration of some neuroleptics , chloropromazine and haloperidol , produced behavioural and ecog slow wave sleep . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
58,
70
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
93,
104
]
} |
[ effects of beta-lactamases on the antibacterial activity of carumonam and aztreonam against klebsiella sp . in comparison with 4 other beta-lactams ] . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
36,
49
]
} | {
"id": "C0004521",
"name": "aztreonam",
"pos": [
76,
85
]
} |
we have studied their antibacterial activities on klebsiella , in comparison with cefotaxime , cefoxitin , cefotetan and imipenem . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
22,
35
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
82,
92
]
} |
we have studied their antibacterial activities on klebsiella , in comparison with cefotaxime , cefoxitin , cefotetan and imipenem . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
22,
35
]
} | {
"id": "C0007557",
"name": "cefoxitin",
"pos": [
95,
104
]
} |
we have studied their antibacterial activities on klebsiella , in comparison with cefotaxime , cefoxitin , cefotetan and imipenem . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
22,
35
]
} | {
"id": "C0007555",
"name": "cefotetan",
"pos": [
107,
116
]
} |
we have studied their antibacterial activities on klebsiella , in comparison with cefotaxime , cefoxitin , cefotetan and imipenem . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
22,
35
]
} | {
"id": "C0020933",
"name": "imipenem",
"pos": [
121,
129
]
} |
in addition , the antibacterial activities of imipenem and of cephamycins remain quite constant within all the strains . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
18,
31
]
} | {
"id": "C0020933",
"name": "imipenem",
"pos": [
46,
54
]
} |
then the antibacterial activity of cefotaxime is fluctuant , which is in relation with a clear susceptibility to the klebsiella beta lactamases . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
9,
22
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
35,
45
]
} |
a first sequence of assays on two antiseptics , one with a chlorhexidine base , the second with a iodine polyvidon base allowed us to study individually the interference of proteins , of ions , and that of the standard exudate . | therapeutic_class_of | {
"id": "C0003205",
"name": "antiseptics",
"pos": [
34,
45
]
} | {
"id": "C0032857",
"name": "iodine polyvidon",
"pos": [
98,
114
]
} |
long term administration of the antipsychotic drugs thioridazine , trifluoperazine , haloperidol , and sulpiride increased body weight in rats . | therapeutic_class_of | {
"id": "C0040615",
"name": "antipsychotic",
"pos": [
32,
45
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
85,
96
]
} |
conversely , after subchronic treatment with neuroleptics such as haloperidol or sulpiride , upregulation of 3h-spiroperidol binding in striatum was not associated with changes of r-pia dependent adenylate cyclase in this area . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
45,
57
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
66,
77
]
} |
differential time course of antidepressant effects after sleep deprivation , ect , and carbamazepine : clinical and theoretical implications . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
28,
42
]
} | {
"id": "C0006949",
"name": "carbamazepine",
"pos": [
87,
100
]
} |
moricizine hcl , a phenothiazine derivative , is a new antiarrhythmic drug that has quinidine-like effects on the myocardium . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drug",
"pos": [
55,
74
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
84,
93
]
} |
the electrophysiologic effects and antiarrhythmic efficacy of moricizine hcl ( 1.5 to 2.0 mg/kg intravenously , and 600 to 800 mg orally/24 hours ) were studied using electrophysiologic testing , ambulatory electrocardiographic monitoring , exercise stress testing and transesophageal stimulation of the left atrium . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
35,
49
]
} | {
"id": "C0079856",
"name": "moricizine",
"pos": [
62,
72
]
} |
finally , the relation between initial lv function and resultant antiarrhythmic efficacy indicates that moricizine hcl controls arrhythmias best in patients with lvef greater than 30 % . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
65,
79
]
} | {
"id": "C0079856",
"name": "moricizine",
"pos": [
104,
114
]
} |
[ study , in mice , of the influence of intestinal parasitic disease on the antiepileptic effects of sodium valproate ] . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic",
"pos": [
76,
89
]
} | {
"id": "C0037567",
"name": "sodium valproate",
"pos": [
101,
117
]
} |
an in vitro pharmacokinetic model was used to study the comparative antibacterial activities of multiple-dose regimens of enoxacin and netilmicin . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
68,
81
]
} | {
"id": "C0027780",
"name": "netilmicin",
"pos": [
135,
145
]
} |
the lodinated antiarrhythmic drug amiodarone frequently causes an elevation of the serum thyroxine ( t4 ) level in patients who remain clinically euthyroid . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drug",
"pos": [
14,
33
]
} | {
"id": "C0002598",
"name": "amiodarone",
"pos": [
34,
44
]
} |
the effects of four antidepressant treatments on platelet tritiated imipramine binding have been studied in 51 hospitalized patients with severe major depressive disorder . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
20,
34
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
68,
78
]
} |
there was an increase in maximum binding ( bmax ) during the first week of treatment with antidepressants and electroconvulsive therapy , which was further magnified after three weeks ' treatment with the serotonin uptake blockers alaproclate and zimeldine hydrochloride , but the bmax values returned to baseline levels with nortriptyline hydrochloride and electroconvulsive therapy . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
90,
105
]
} | {
"id": "C0700459",
"name": "nortriptyline hydrochloride",
"pos": [
326,
353
]
} |
the purpose of this investigation was to determine the relationship between serum levels of the neuroleptic agent thiothixene and tardive dyskinesia in schizophrenics of a wide age range . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic agent",
"pos": [
96,
113
]
} | {
"id": "C0039955",
"name": "thiothixene",
"pos": [
114,
125
]
} |
the beta-adrenergic blocking agents propranolol and butoxamine , and the antiarrhythmic agent quinidine , produced a concentration-dependent stimulation of rna synthesis in cardiac and hepatic mitochondria . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agent",
"pos": [
73,
93
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
94,
103
]
} |
the discovery of the effectiveness of oral antidotes such as n-acetylcysteine ( nac ) for acetaminophen poisonings has raised questions about the appropriateness of concomitant administration with activated charcoal . | therapeutic_class_of | {
"id": "C0003295",
"name": "antidotes",
"pos": [
43,
52
]
} | {
"id": "C0001047",
"name": "n-acetylcysteine",
"pos": [
61,
77
]
} |
the antifungal imidazole , ketoconazole , was tested for effects on 1,25-dihydroxyvitamin d-3 ( 1,25- ( oh ) 2d3 ) metabolism and binding in intact osteoblast-like osteogenic sarcoma cells ( umr-106 ) . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
4,
14
]
} | {
"id": "C0022625",
"name": "ketoconazole",
"pos": [
27,
39
]
} |
these results suggest that less antidopaminergic activity of rhal in this neuroleptic test might be explained by the lesser conversion of rhal to hal . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
74,
85
]
} | {
"id": "C0018546",
"name": "hal",
"pos": [
146,
149
]
} |
of all patients receiving second-line drugs , 10 % were prescribed antimalarials , with hydroxychloroquine being used four times more frequently than chloroquine . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarials",
"pos": [
67,
80
]
} | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
150,
161
]
} |
we analyzed 99 patients ' serum samples for concentrations of a new antiarrhythmic agent , flecainide acetate , by fluorescence polarization immunoassay ( fpia ) and `` '' high-performance '' '' liquid chromatography ( hplc ) . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agent",
"pos": [
68,
88
]
} | {
"id": "C0086303",
"name": "flecainide acetate",
"pos": [
91,
109
]
} |
the chemistry , mechanism of action , antimicrobial spectrum , pharmacokinetics , clinical efficacy , adverse effects , and dosage and administration of ciprofloxacin and norfloxacin are reviewed , and mechanisms of antimicrobial resistance and drug and laboratory interactions are described . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial",
"pos": [
38,
51
]
} | {
"id": "C0008809",
"name": "ciprofloxacin",
"pos": [
153,
166
]
} |
the chemistry , mechanism of action , antimicrobial spectrum , pharmacokinetics , clinical efficacy , adverse effects , and dosage and administration of ciprofloxacin and norfloxacin are reviewed , and mechanisms of antimicrobial resistance and drug and laboratory interactions are described . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial",
"pos": [
38,
51
]
} | {
"id": "C0028365",
"name": "norfloxacin",
"pos": [
171,
182
]
} |
the isolated pneumococci were either fully sensitive to penicillin and other antimicrobial agents commonly used or relatively resistant to penicillin and resistant to cloxacillin , tetracycline , erythromycin , sulphatrimethoprim and clindamycin . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial agents",
"pos": [
77,
97
]
} | {
"id": "C0039644",
"name": "tetracycline",
"pos": [
181,
193
]
} |
the isolated pneumococci were either fully sensitive to penicillin and other antimicrobial agents commonly used or relatively resistant to penicillin and resistant to cloxacillin , tetracycline , erythromycin , sulphatrimethoprim and clindamycin . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial agents",
"pos": [
77,
97
]
} | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
196,
208
]
} |
a 26-year-old woman committed suicide by ingestion of a large quantity of tocainide , a recently developed oral antiarrhythmic agent with chemical similarities to lidocaine . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agent",
"pos": [
112,
132
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
163,
172
]
} |
a review of other previously reported cases of exserohilum and bipolaris infections show a favourable outcome in most patients who receive systemic antifungal treatment with amphotericin b . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
148,
158
]
} | {
"id": "C0002679",
"name": "amphotericin b",
"pos": [
174,
188
]
} |
the pka values of the conjugate acids of the antimalarial drug chloroquine were determined at various temperatures using fluorescence spectrophotometry and nonlinear regression in the data analysis . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial drug",
"pos": [
45,
62
]
} | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
63,
74
]
} |
antiarrhythmic activity of two quinidine metabolites in experimental reperfusion arrhythmia : relative potency and pharmacodynamic interaction with the parent drug . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
0,
14
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
31,
40
]
} |
we investigated the antiarrhythmic activity of two major metabolites of quinidine in human , 3-hydroxyquinidine and quinidine-n-oxide , alone and in combination with the parent drug in an experimental model using reperfusion arrhythmias in an isolated rat heart preparation . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
20,
34
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
116,
125
]
} |
although many antimicrobial agents that have been available for some time remain effective in the eradication of bacteriuria , the recent introduction of the fluoroquinolone norfloxacin represents an important addition to the therapeutic armamentarium . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial agents",
"pos": [
14,
34
]
} | {
"id": "C0028365",
"name": "norfloxacin",
"pos": [
174,
185
]
} |
the antiarrhythmic effects can not be explained by non-specific quinidine-like actions which was also confirmed by the lacking prostaglandin action on the diastolic stimulus threshold . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
4,
18
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
64,
73
]
} |
comparison of the therapeutic effect of lithium and neuroleptic treatment ( haloperidol , octoclothepin , oxyprothepin ) in mania patients [ proceedings ] . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
52,
63
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
76,
87
]
} |
this antibiotic offers advantages of antibacterial effectiveness and at the same time retains the safety of penicillin g and cephalothin in animals . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
37,
50
]
} | {
"id": "C0030827",
"name": "penicillin g",
"pos": [
108,
120
]
} |
bromperidol , a new potent and long-acting neuroleptic of the butyrophenone series , and haloperidol were injected s.c. at the doses 0.01 , 0.02 , 0.04 and 0.08 mg/kg , in rats implanted with electrodes in the lateral hypothalamic region of the medial forebrain bundle . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
43,
54
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
89,
100
]
} |
the effects of five antiarrhythmic drugs ( quinidine , procainamide , lignocaine , phenytoin and propranolol ) were studied on pacemaker activity in the sinoatrial node and on contractility in twenty-three isolated , blood-perfused atrium preparations of dogs . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
20,
34
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
43,
52
]
} |
the effects of five antiarrhythmic drugs ( quinidine , procainamide , lignocaine , phenytoin and propranolol ) were studied on pacemaker activity in the sinoatrial node and on contractility in twenty-three isolated , blood-perfused atrium preparations of dogs . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
20,
34
]
} | {
"id": "C0033216",
"name": "procainamide",
"pos": [
55,
67
]
} |
the effects of five antiarrhythmic drugs ( quinidine , procainamide , lignocaine , phenytoin and propranolol ) were studied on pacemaker activity in the sinoatrial node and on contractility in twenty-three isolated , blood-perfused atrium preparations of dogs . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
20,
34
]
} | {
"id": "C0023660",
"name": "lignocaine",
"pos": [
70,
80
]
} |
hypotheses on the electrophysiological mechanism of the observed effects are analyzed , and some clinico-electrophysiopathological correlations are traced , which help in the understanding of the anti-arrhythmic activity of procainamide . | therapeutic_class_of | {
"id": "C0003195",
"name": "anti-arrhythmic",
"pos": [
196,
211
]
} | {
"id": "C0033216",
"name": "procainamide",
"pos": [
224,
236
]
} |
three patients , aged 23-33 years , with the diagnosis of schizophrenia , developed symptoms of tardive dyskinesia while receiving neuroleptic treatment , mostly with haloperidol . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
131,
142
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
167,
178
]
} |
the new antidiarrheal drug difenoxin hydrochloride is a preparation with a broad range of action ; | therapeutic_class_of | {
"id": "C0003292",
"name": "antidiarrheal drug",
"pos": [
8,
26
]
} | {
"id": "C0770333",
"name": "difenoxin hydrochloride",
"pos": [
27,
50
]
} |
[ therapeutic efficacy of tricyclic and antidepressive agents . comparative double blind test of amitriptyline and mianserin ( org gb 94 ) ] . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressive agents",
"pos": [
40,
61
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
97,
110
]
} |
[ antiarrhythmic , cardiovascular and toxic actions of n , n'-bis- [ 3- ( 2'-ethoxyphenoxy ) -2-hydroxypropyl ] -ethlenediamine ( falirytmin ) as compared to propranolol , quinidine and ajmaline ] . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
2,
16
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
172,
181
]
} |
the effects of two antiarrhythmic drugs ( verapamil , amiodarone ) on echo-zone duration , on initiation and on prophylactic long-term treatment of paroxysmal tachycardias are also reported and discussed . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
19,
33
]
} | {
"id": "C0002598",
"name": "amiodarone",
"pos": [
54,
64
]
} |
antimicrobial elution disks containing amoxicillin-clavulanic acid ( augmentin ) , cefotetan , ciprofloxacin , or norfloxacin were tested in the avantage automated susceptibility test system . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial",
"pos": [
0,
13
]
} | {
"id": "C0008809",
"name": "ciprofloxacin",
"pos": [
95,
108
]
} |
antimicrobial elution disks containing amoxicillin-clavulanic acid ( augmentin ) , cefotetan , ciprofloxacin , or norfloxacin were tested in the avantage automated susceptibility test system . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial",
"pos": [
0,
13
]
} | {
"id": "C0028365",
"name": "norfloxacin",
"pos": [
114,
125
]
} |
the purpose of the present report is to study the effects of antidepressants such as trimipramine , amitriptyline , maprotiline and mianserin on severe gastric mucosal lesions produced by ethanol in comparison with cimetidine ( h2-antihistamine ) and dexchlorepheniramine ( h2-antihistamine ) . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
61,
76
]
} | {
"id": "C0041056",
"name": "trimipramine",
"pos": [
85,
97
]
} |
the purpose of the present report is to study the effects of antidepressants such as trimipramine , amitriptyline , maprotiline and mianserin on severe gastric mucosal lesions produced by ethanol in comparison with cimetidine ( h2-antihistamine ) and dexchlorepheniramine ( h2-antihistamine ) . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
61,
76
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
100,
113
]
} |
we studied the effect of repeated treatment ( twice daily for 14 consecutive days ) with the antidepressant drugs imipramine , citalopram and mianserin ( all the drugs administered in a dose of 10 mg/kg po ) on the 8-oh-dpat-induced increase in the serum corticosterone concentration . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant drugs",
"pos": [
93,
113
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
114,
124
]
} |
for this reason the use of the different kinds of antidepressants in finland had changed : the sales of doxepin and amitriptyline have increased and those of maprotiline and mianserin have decreased . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
50,
65
]
} | {
"id": "C0013085",
"name": "doxepin",
"pos": [
104,
111
]
} |
for this reason the use of the different kinds of antidepressants in finland had changed : the sales of doxepin and amitriptyline have increased and those of maprotiline and mianserin have decreased . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
50,
65
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
116,
129
]
} |
as to the sales , amitriptyline has to be considered to be the leading antidepressant followed by doxepin , mianserin and maprotiline . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
71,
85
]
} | {
"id": "C0013085",
"name": "doxepin",
"pos": [
98,
105
]
} |
when an antidepressant was the cause of death the fatality ratio was highest for doxepin ( 6.4 ) followed by maprotiline ( 4.3 ) , amitriptyline ( 4.0 ) and mianserin ( 1 ) . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
8,
22
]
} | {
"id": "C0013085",
"name": "doxepin",
"pos": [
81,
88
]
} |
when an antidepressant was the cause of death the fatality ratio was highest for doxepin ( 6.4 ) followed by maprotiline ( 4.3 ) , amitriptyline ( 4.0 ) and mianserin ( 1 ) . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
8,
22
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
131,
144
]
} |
to examine the natural history of long-term anti-arrhythmic therapy in patients with benign and potentially lethal ventricular premature complexes ( vpcs ) , 28 patients with initial efficacy with moricizine ( greater than 75 % suppression of baseline mean vpcs/hr and greater than 90 % suppression of repetitive vpcs ) were prospectively followed for 1 to 56 ( mean +/- standard deviation 25 +/- 17 ) months . | therapeutic_class_of | {
"id": "C0003195",
"name": "anti-arrhythmic",
"pos": [
44,
59
]
} | {
"id": "C0079856",
"name": "moricizine",
"pos": [
197,
207
]
} |
the principle of the combined use of antipsychotics and sedative-hypnotics was further tested by comparing two new combinations : thiothixene , 5 mg , and lorazepam , 4 mg , versus haloperidol , 5 mg , and phenobarbital sodium , 130 mg . | therapeutic_class_of | {
"id": "C0040615",
"name": "antipsychotics",
"pos": [
37,
51
]
} | {
"id": "C0039955",
"name": "thiothixene",
"pos": [
130,
141
]
} |
the principle of the combined use of antipsychotics and sedative-hypnotics was further tested by comparing two new combinations : thiothixene , 5 mg , and lorazepam , 4 mg , versus haloperidol , 5 mg , and phenobarbital sodium , 130 mg . | therapeutic_class_of | {
"id": "C0040615",
"name": "antipsychotics",
"pos": [
37,
51
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
181,
192
]
} |
the disposition of the enantiomers of the antiarrhythmic drug flecainide has been studied in five extensive ( em ) and five poor ( pm ) metabolisers of sparteine/debrisoquine after administration of 50 mg of racemic flecainide acetate under conditions of high urinary flow rate and acidic urinary ph . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drug",
"pos": [
42,
61
]
} | {
"id": "C0016229",
"name": "flecainide",
"pos": [
216,
226
]
} |
anti-arrhythmic effects of amiodarone and desethylamiodarone on malignant ventricular arrhythmias arising as a consequence of ischaemia and reperfusion in the anaesthetised rat . | therapeutic_class_of | {
"id": "C0003195",
"name": "anti-arrhythmic",
"pos": [
0,
15
]
} | {
"id": "C0002598",
"name": "amiodarone",
"pos": [
50,
60
]
} |
in vivo and in vitro effects of the antifungal agent miconazole on estrogen biosynthesis in human breast cancer . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal agent",
"pos": [
36,
52
]
} | {
"id": "C0025942",
"name": "miconazole",
"pos": [
53,
63
]
} |
these findings suggest that the anti-manic activity of cbz is neither related to a dopamine blocking action similar to that of neuroleptics , or to an attenuation of dopamine regulatory mechanisms similar to that of lithium . | therapeutic_class_of | {
"id": "C0242911",
"name": "anti-manic",
"pos": [
32,
42
]
} | {
"id": "C0006949",
"name": "cbz",
"pos": [
55,
58
]
} |
it is also seems the central histamine receptors may partially contribute towards the mechanism of antidepressant effect of imipramine . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
99,
113
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
124,
134
]
} |
stimulation of glutamine metabolism by the antiepileptic drug , sodium valproate , in isolated dog kidney tubules . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drug",
"pos": [
43,
61
]
} | {
"id": "C0037567",
"name": "sodium valproate",
"pos": [
64,
80
]
} |
the antiepileptic sodium valproate ( vpa ) systematically induces an asymptomatic hyperammonemia of renal origin in fasting normal human volunteers and in fasting rats , accompanied by an increased renal glutamine uptake . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic",
"pos": [
4,
17
]
} | {
"id": "C0037567",
"name": "sodium valproate",
"pos": [
18,
34
]
} |
to assess the role of sodium channel blockade in the enhanced anti-arrhythmic activity of mexiletine-quinidine combination we determined whether the electrophysiological and anti-arrhythmic effects of tetrodotoxin combined with mexiletine or quinidine mimicked the effect seen with mexiletine combined with quinidine . | therapeutic_class_of | {
"id": "C0003195",
"name": "anti-arrhythmic",
"pos": [
62,
77
]
} | {
"id": "C0025887",
"name": "mexiletine",
"pos": [
282,
292
]
} |
to assess the role of sodium channel blockade in the enhanced anti-arrhythmic activity of mexiletine-quinidine combination we determined whether the electrophysiological and anti-arrhythmic effects of tetrodotoxin combined with mexiletine or quinidine mimicked the effect seen with mexiletine combined with quinidine . | therapeutic_class_of | {
"id": "C0003195",
"name": "anti-arrhythmic",
"pos": [
62,
77
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
307,
316
]
} |
combinations of mexiletine and quinidine at concentrations which alone had little electrophysiological activity produced anti-arrhythmic activity greater than that seen with high concentrations of mexiletine or quinidine alone . | therapeutic_class_of | {
"id": "C0003195",
"name": "anti-arrhythmic",
"pos": [
121,
136
]
} | {
"id": "C0025887",
"name": "mexiletine",
"pos": [
197,
207
]
} |
combinations of mexiletine and quinidine at concentrations which alone had little electrophysiological activity produced anti-arrhythmic activity greater than that seen with high concentrations of mexiletine or quinidine alone . | therapeutic_class_of | {
"id": "C0003195",
"name": "anti-arrhythmic",
"pos": [
121,
136
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
211,
220
]
} |
the combination of similarly low concentrations of tetrodotoxin and quinidine also produced enhanced anti-arrhythmic efficacy and enhanced prolongation of ventricular refractoriness and conduction which mimicked the effect of mexiletine and quinidine in combination . | therapeutic_class_of | {
"id": "C0003195",
"name": "anti-arrhythmic",
"pos": [
101,
116
]
} | {
"id": "C0025887",
"name": "mexiletine",
"pos": [
226,
236
]
} |
the combination of similarly low concentrations of tetrodotoxin and quinidine also produced enhanced anti-arrhythmic efficacy and enhanced prolongation of ventricular refractoriness and conduction which mimicked the effect of mexiletine and quinidine in combination . | therapeutic_class_of | {
"id": "C0003195",
"name": "anti-arrhythmic",
"pos": [
101,
116
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
241,
250
]
} |
since tetrodotoxin is a highly specific sodium channel blocker , these data suggest that the enhanced antiarrhythmic activity of mexiletine-quinidine combination therapy involves , at least in part , blockade of the cardiac sodium channel . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
102,
116
]
} | {
"id": "C0025887",
"name": "mexiletine",
"pos": [
129,
139
]
} |
since tetrodotoxin is a highly specific sodium channel blocker , these data suggest that the enhanced antiarrhythmic activity of mexiletine-quinidine combination therapy involves , at least in part , blockade of the cardiac sodium channel . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
102,
116
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
140,
149
]
} |
mean ejection fraction and mean lvedp did not differ between responders and non-responders , yet the presence of a left ventricular aneurysm correlated with a lack of antiarrhythmic response to flecainide . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
167,
181
]
} | {
"id": "C0016229",
"name": "flecainide",
"pos": [
194,
204
]
} |
the neuroleptic action of haloperidol , intraperitoneally injected into mice in micellar solution of non-ionic block copolymer surfactant ( pluronic p-85 ) in water , increased several-fold if compared with that observed for haloperidol aqueous solution . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
4,
15
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
225,
236
]
} |
the antibacterial activity in vitro of ceftazidime and ceftriaxone was investigated against 575 recent clinical isolates . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0007559",
"name": "ceftazidime",
"pos": [
39,
50
]
} |
the antibacterial activity in vitro of ceftazidime and ceftriaxone was investigated against 575 recent clinical isolates . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0007561",
"name": "ceftriaxone",
"pos": [
55,
66
]
} |
morinda lucida extracts , the stem bark , the root bark and the leaves were screened for antimalarial activity in a `` '' 4-day schizontocidal test ' against a chloroquine-sensitive strain of p. berghei berghei in mice . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial",
"pos": [
89,
101
]
} | {
"id": "C0008269",
"name": "chloroquin",
"pos": [
160,
170
]
} |
the healing rate of duodenal ulcers may be accelerated by secretory inhibitors such as histamine h2-receptor antagonists and pirenzepine , by antacids , by protective drugs such as sucralfate and colloidal bismuth , and by antidepressant drugs such as trimipramine . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
223,
237
]
} | {
"id": "C0041056",
"name": "trimipramine",
"pos": [
252,
264
]
} |
since electrophysiological actions of antiarrhythmic drugs are examined in different buffer systems , we set out to examine the influence of buffers on lidocaine 's electrophysiological actions by measuring recovery kinetics of maximum upstroke velocity ( dv/dtmax ) in lidocaine solutions buffered with hco-3-co2 , n-2-hydroxyethylpiperazine-n'-2-ethanesulfonic acid ( hepes ) , and tris ( hydroxymethyl ) aminomethane ( tris ) at extracellular ph 7.4 . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
38,
52
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
270,
279
]
} |
these data indicate that the widely used antiseptic p-i , depending on its concentration , can either stimulate or inhibit neutrophil migration . | therapeutic_class_of | {
"id": "C0003205",
"name": "antiseptic",
"pos": [
41,
51
]
} | {
"id": "C0032857",
"name": "p-i",
"pos": [
52,
55
]
} |
the antibacterial activities of other agents tested relative to ofloxacin were rifampin greater than ofloxacin greater than josamycin greater than pipemidic acid . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0035608",
"name": "rifampin",
"pos": [
79,
87
]
} |
the antibacterial activities of ceftazidime and netilmicin were studied in a two-compartment in vitro model . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0007559",
"name": "ceftazidime",
"pos": [
32,
43
]
} |
the antibacterial activities of ceftazidime and netilmicin were studied in a two-compartment in vitro model . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0027780",
"name": "netilmicin",
"pos": [
48,
58
]
} |
[ anti-arrhythmic effect of amiodarone in the 24 hours following a single oral loading dose . clinical and pharmacological study ] . | therapeutic_class_of | {
"id": "C0003195",
"name": "anti-arrhythmic",
"pos": [
2,
17
]
} | {
"id": "C0002598",
"name": "amiodarone",
"pos": [
28,
38
]
} |
the clinical pharmacokinetics of the 4 depot antipsychotics for which plasma level studies are available ( i.e . fluphenazine enanthate and decanoate , haloperidol decanoate , clopenthixol decanoate and flupenthixol decanoate ) are reviewed . | therapeutic_class_of | {
"id": "C0040615",
"name": "antipsychotics",
"pos": [
45,
59
]
} | {
"id": "C0062103",
"name": "haloperidol decanoate",
"pos": [
152,
173
]
} |
in contrast to drug induced arrhythmias encountered with other type i antiarrhythmic agents , the proarrhythmic effects of propafenone were not associated with marked qt prolongation . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agents",
"pos": [
70,
91
]
} | {
"id": "C0033429",
"name": "propafenone",
"pos": [
123,
134
]
} |
the latter type of behavioral pathology alone was selectively averted by administering the classical neuroleptics fluorophenazine , haloperidol and its analog azaperone . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
101,
113
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
132,
143
]
} |
atypical neuroleptics and the the antidepressant imipramine were less effective and reduced but animals ' motor excitation induced by madopar according to the extrapolation avoidance test . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
34,
48
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
49,
59
]
} |
studies of the antidepressants evidenced that inkazan is a highly selective inhibitor of the reverse uptake of serotonin , whereas other antidepressants such as zimelidine , imipramine and norzimelidine were discovered to inhibit the uptake of serotonin to a larger extent than that of other transmitters . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
15,
30
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
174,
184
]
} |
n- ( 2-mercapto-2-methylpropionyl ) -l-cysteine ( sa 96 ) , an antirheumatic agent , and the main metabolite of sa 96 , n- [ 2-methyl-2- ( methylthio ) propionyl ] -l-cysteine ( sa 679 ) , were investigated for the effects on vitamin b6 ( vb6 ) , metals and skin collagen in rats in comparison with d-penicillamine ( d-pc ) . | therapeutic_class_of | {
"id": "C0003191",
"name": "antirheumatic agent",
"pos": [
63,
82
]
} | {
"id": "C0030817",
"name": "d-penicillamine",
"pos": [
299,
314
]
} |
the effects of antiarrhythmic drugs , aprindine , mexiletine and lidocaine , on rat erythrocytes , isolated rat hepatocytes and dppc-liposomes were studied at various concentrations . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
15,
29
]
} | {
"id": "C0025887",
"name": "mexiletine",
"pos": [
50,
60
]
} |
the effects of antiarrhythmic drugs , aprindine , mexiletine and lidocaine , on rat erythrocytes , isolated rat hepatocytes and dppc-liposomes were studied at various concentrations . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
15,
29
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
65,
74
]
} |
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