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11 antibacterial drugs , i. e. tobramycin , sisomicin , gentamicin , amicacin , neomycin , carbenicillin , polymyxin m , erythromycin , tetracycline , rifampicin and dioxidine proved to be most active against acinetobacter calcoaceticus . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
3,
16
]
} | {
"id": "C0035608",
"name": "rifampicin",
"pos": [
151,
161
]
} |
the excretion of the widely used antiarrhythmic agent procainamide into the bile and saliva of rats with chronic renal failure ( crf ) induced by a two stage-total nephrectomy was studied . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agent",
"pos": [
33,
53
]
} | {
"id": "C0033216",
"name": "procainamide",
"pos": [
54,
66
]
} |
the neuroleptic-induced decrease began to appear within a few days of treatment and did not show tolerance over 1-2 months of treatment with haloperidol . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
4,
15
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
141,
152
]
} |
these data suggested that 18f-fdm , which is a by-product of 18f-fdg synthesis was also an excellent cancer diagnostic agent as well as 18f-fdg . | therapeutic_class_of | {
"id": "C0358514",
"name": "diagnostic agent",
"pos": [
108,
124
]
} | {
"id": "C0046056",
"name": "18f-fdg",
"pos": [
136,
143
]
} |
acute coronary artery occlusion-reperfusion-induced arrhythmias in rats , dogs and pigs : antiarrhythmic evaluation of quinidine , procainamide and lidocaine . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
90,
104
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
119,
128
]
} |
acute coronary artery occlusion-reperfusion-induced arrhythmias in rats , dogs and pigs : antiarrhythmic evaluation of quinidine , procainamide and lidocaine . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
90,
104
]
} | {
"id": "C0033216",
"name": "procainamide",
"pos": [
131,
143
]
} |
acute coronary artery occlusion-reperfusion-induced arrhythmias in rats , dogs and pigs : antiarrhythmic evaluation of quinidine , procainamide and lidocaine . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
90,
104
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
148,
157
]
} |
fluvoxamine , ( e ) -5-methoxy-4'- ( trifluoromethyl ) valerophenone o-2 ( 2-aminoethyl ) oxime , a new antidepressant drug inhibiting serotonin ( 5-ht ) uptake , was studied in rats and mice in order to check whether it has any central anti-5-ht activity , as do some tricyclic antidepressants , e.g . amitriptyline and doxepin . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant drug",
"pos": [
104,
123
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
303,
316
]
} |
fluvoxamine , ( e ) -5-methoxy-4'- ( trifluoromethyl ) valerophenone o-2 ( 2-aminoethyl ) oxime , a new antidepressant drug inhibiting serotonin ( 5-ht ) uptake , was studied in rats and mice in order to check whether it has any central anti-5-ht activity , as do some tricyclic antidepressants , e.g . amitriptyline and doxepin . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant drug",
"pos": [
104,
123
]
} | {
"id": "C0013085",
"name": "doxepin",
"pos": [
321,
328
]
} |
amoxapine , a new antidepressant of the dibenzoxazepine class , was compared with amitriptyline in 80 patients with primary unipolar depressive disorders . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
18,
32
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
82,
95
]
} |
the potencies of various antidepressant drugs in reducing [ 3h ] desipramine binding correlate with their inhibition of neuronal [ 3h ] norepinephrine accumulation . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
25,
39
]
} | {
"id": "C0011685",
"name": "desipramine",
"pos": [
65,
76
]
} |
of the four antiepileptic drugs investigated in the present study , namely phenytoin , carbamazepine , phenobarbital , and valproate , only phenytoin blocked the acetylcholine-stimulated 32p labeling of phosphatidylinositol and phosphatidic acid , and the acetylcholine-stimulated breakdown of polyphosphoinositides . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drugs",
"pos": [
12,
31
]
} | {
"id": "C0031507",
"name": "phenytoin",
"pos": [
140,
149
]
} |
it was concluded that certain antiepileptic drugs , such as phenytoin , could exert their pharmacological actions through their antimuscarinic effects . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drugs",
"pos": [
30,
49
]
} | {
"id": "C0031507",
"name": "phenytoin",
"pos": [
60,
69
]
} |
chronic treatment of rats with the antidepressant , amitriptyline , resulted in a reduced number of cerebral cortical 5ht2 receptors measured as cinanserin displaceable [ 3h ] spiperone binding . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
35,
49
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
52,
65
]
} |
an attempt was made to evaluate tranquilizing effects of three neuroleptic drugs ( 10 and 50 mg melperone , 1 mg haloperidol , and 50 mg chlorpromazine ) and diazepam ( 10 mg ) on experimental anxiety in normal subjects . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
63,
74
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
113,
124
]
} |
antidepressant effect of femoxetine and desipramine and relationship to the concentration of amine metabolites in cerebrospinal fluid . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
0,
14
]
} | {
"id": "C0011685",
"name": "desipramine",
"pos": [
40,
51
]
} |
the antidepressant and biochemical effects of femoxetine , a selective serotonin uptake inhibitor , and desipramine , a selective nor-adrenaline uptake inhibitor , have been compared in a double-blind study in 42 outpatients with depressive illness . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
4,
18
]
} | {
"id": "C0011685",
"name": "desipramine",
"pos": [
104,
115
]
} |
[ comparative study of the antibacterial activity of aminoglycoside antibiotics and their combinations with carbenicillin against pseudomonas aeruginosa ] . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
27,
40
]
} | {
"id": "C0006976",
"name": "carbenicillin",
"pos": [
108,
121
]
} |
antibacterial activity of 7 aminoglycoside antibiotics and combinations of tobramycin or gentamicin with carbenicillin was studied with respect to 33 clinical strains of ps . aeruginosa . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
0,
13
]
} | {
"id": "C0040341",
"name": "tobramycin",
"pos": [
75,
85
]
} |
antibacterial activity of 7 aminoglycoside antibiotics and combinations of tobramycin or gentamicin with carbenicillin was studied with respect to 33 clinical strains of ps . aeruginosa . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
0,
13
]
} | {
"id": "C0006976",
"name": "carbenicillin",
"pos": [
105,
118
]
} |
combination of tobramycin or gentamicin with carbenicillin increased the antibacterial activity of the aminoglycoside antibiotics by 2-16 times and that of carbenicillin by 2-32 times . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
73,
86
]
} | {
"id": "C0006976",
"name": "carbenicillin",
"pos": [
156,
169
]
} |
type i antiarrhythmic drugs , especially disopyramide and quinidine , were effective for the treatment of the re-entry tachycardia because of their depressive action on the nodoventricular pathway . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drugs",
"pos": [
7,
27
]
} | {
"id": "C0012702",
"name": "disopyramide",
"pos": [
41,
53
]
} |
type i antiarrhythmic drugs , especially disopyramide and quinidine , were effective for the treatment of the re-entry tachycardia because of their depressive action on the nodoventricular pathway . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drugs",
"pos": [
7,
27
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
58,
67
]
} |
although both drugs significantly reduced vpds relative to placebo , ethmozine was a superior antiarrhythmic drug in ach9eving near-total abolition of vpds ( 30 % of patients ) , which was never observed during disopyramide dosing ( p less than .05 ) . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drug",
"pos": [
94,
113
]
} | {
"id": "C0012702",
"name": "disopyramide",
"pos": [
211,
223
]
} |
more generally , the present results , as well as some literature data , support the concept that the ability to form hydrogen bonds as well as a certain degree of motional freedom of the phenyl groups are important sar features in antiepileptic phenytoin-like drugs . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic",
"pos": [
232,
245
]
} | {
"id": "C0031507",
"name": "phenytoin",
"pos": [
246,
255
]
} |
assuming that metabolic interaction in the arene oxide pathway resulting in accumulation of epoxide intermediates of antiepileptic drugs could be responsible for teratogenesis , the ratio of carbamazepine to carbamazepine-10 , 11-epoxide concentrations in serum was determined in adult patients with epilepsy who were treated with carbamazepine only and with different combinations of phenobarbitone , valproate , and/or phenytoin . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drugs",
"pos": [
117,
136
]
} | {
"id": "C0031507",
"name": "phenytoin",
"pos": [
421,
430
]
} |
the postulated beta adrenoceptor blocking properties of the new antiarrhythmic drug propafenone were studied by in vivo comparison against placebo and propranolol in the antagonism of both exercise- and isoproterenol-induced tachycardia and by in vitro radioligand binding studies of animal and human left ventricular muscle membrane preparations . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
64,
78
]
} | {
"id": "C0033429",
"name": "propafenone",
"pos": [
84,
95
]
} |
although the in vitro antibacterial activity of clindamycin and pirlimycin are nearly identical , the latter compound is 2-20 times more active than clindamycin when administered to mice experimentally infected with strains of staphylococcus aureus , streptococcus pyogenes , streptococcus pneumoniae , bacteroides fragilis , and plasmodium berghei . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
22,
35
]
} | {
"id": "C0008947",
"name": "clindamycin",
"pos": [
149,
160
]
} |
in eastern thailand the increasing resistance of plasmodium falciparum to all available antimalarial drugs prompted a reassessment of chloroquine in combination with either erythromycin or tetracycline . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial",
"pos": [
88,
100
]
} | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
134,
145
]
} |
the affinity of 15 antipsychotic drugs for 3h-haloperidol binding sites was highly correlated ( r = 0.94 ) with their inhibitory potency at a subset of 3h-da binding sites . | therapeutic_class_of | {
"id": "C0040615",
"name": "antipsychotic drugs",
"pos": [
19,
38
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
46,
57
]
} |
in these children phenoxymethylpenicillin ( penicillin v ) was the predominant antimicrobial ( approximately 70 % ) , followed by erythromycin and medium wide-spectrum penicillins ( ampicillin/amoxycillin ) . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial",
"pos": [
79,
92
]
} | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
130,
142
]
} |
two patients who developed ventricular arrhythmias were taking other antiarrhythmic agents , and in this series proarrhythmic effects occurred with both normal and high flecainide concentrations . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agents",
"pos": [
69,
90
]
} | {
"id": "C0016229",
"name": "flecainide",
"pos": [
169,
179
]
} |
electrophysiologic and hemodynamic effects of propafenone , a new antiarrhythmic agent , on the anesthetized , closed-chest dog : comparative study with lidocaine . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
66,
80
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
153,
162
]
} |
the relative hemodynamic and electrophysiologic effects of a new antiarrhythmic drug , propafenone , and lidocaine were evaluated in eight closed-chest , anesthetized dogs . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
65,
79
]
} | {
"id": "C0033429",
"name": "propafenone",
"pos": [
87,
98
]
} |
the relative hemodynamic and electrophysiologic effects of a new antiarrhythmic drug , propafenone , and lidocaine were evaluated in eight closed-chest , anesthetized dogs . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
65,
79
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
105,
114
]
} |
the results of antiarrhythmic testing in a variety of animal models indicate that flecainide acetate has potent antiarrhythmic activity . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
15,
29
]
} | {
"id": "C0086303",
"name": "flecainide acetate",
"pos": [
82,
100
]
} |
in a study of the corneal toxicity of some commonly used presurgical skin antiseptics , we used biomicroscopy , corneal pachymetry , healing studies , and electron microscopy to compare tincture of iodine ( 2 % iodine , 2.35 % sodium iodine , and 46 % ethanol ) , hibiclens ( 4 % chlorhexidine and 4 % isopropyl alcohol with detergent ) , phisohex ( 3 % hexachlorophene and detergent ) , lavacol ( 70 % ethanol ) , 7.5 % povidone iodine scrub ( with a detergent ) , and 10 % povidone iodine solution ( without a detergent ) in rabbits . | therapeutic_class_of | {
"id": "C0003205",
"name": "antiseptics",
"pos": [
74,
85
]
} | {
"id": "C0019435",
"name": "hexachlorophene",
"pos": [
354,
369
]
} |
in vitro metabolism of the antimalarial agent primaquine by mouse liver enzymes and identification of a methemoglobin-forming metabolite . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial agent",
"pos": [
27,
45
]
} | {
"id": "C0033126",
"name": "primaquine",
"pos": [
46,
56
]
} |
the anti-arrhythmic effectiveness of an oral treatment schedule combining three times 200 mg mexiletine and three times 20 mg propranolol daily was compared with each drug given alone in 14 patients with stable or reproducible ventricular extrasystoles of various aetiologies , randomly divided into two groups for different therapy sequences . | therapeutic_class_of | {
"id": "C0003195",
"name": "anti-arrhythmic",
"pos": [
4,
19
]
} | {
"id": "C0025887",
"name": "mexiletine",
"pos": [
93,
103
]
} |
alprazolam has antidepressant activity and has been shown to be similar in efficacy to imipramine in the treatment of unipolar depression . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
15,
29
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
87,
97
]
} |
inhibition of [ 3h ] nitrendipine binding by other antiarrhythmic molecules like amiodarone , f13004 and bepridil was observed . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
51,
65
]
} | {
"id": "C0002598",
"name": "amiodarone",
"pos": [
81,
91
]
} |
in a prospective multicenter study the phenomenon of an anicteric reaction with increasing enzyme activities is tested with the antiarrhythmics prajmalin , propafenone , disopyramide and sparteine and additionally with nitroglycerine . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmics",
"pos": [
128,
143
]
} | {
"id": "C0033429",
"name": "propafenone",
"pos": [
156,
167
]
} |
in a prospective multicenter study the phenomenon of an anicteric reaction with increasing enzyme activities is tested with the antiarrhythmics prajmalin , propafenone , disopyramide and sparteine and additionally with nitroglycerine . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmics",
"pos": [
128,
143
]
} | {
"id": "C0012702",
"name": "disopyramide",
"pos": [
170,
182
]
} |
effectiveness of the antimicrobial removal device , bactec 16b medium , and thiol broth in neutralizing antibacterial activities of imipenem , norfloxacin , and related agents . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial",
"pos": [
21,
34
]
} | {
"id": "C0028365",
"name": "norfloxacin",
"pos": [
143,
154
]
} |
effectiveness of the antimicrobial removal device , bactec 16b medium , and thiol broth in neutralizing antibacterial activities of imipenem , norfloxacin , and related agents . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
104,
117
]
} | {
"id": "C0020933",
"name": "imipenem",
"pos": [
132,
140
]
} |
the thiol broth was more effective than the ard and the bactec 16b medium in inactivating imipenem , but it had no effect on the antibacterial activity of norfloxacin . | therapeutic_class_of | {
"id": "C1136254",
"name": "ard",
"pos": [
44,
47
]
} | {
"id": "C0028365",
"name": "norfloxacin",
"pos": [
155,
166
]
} |
synthesis of certain hydroxy analogues of the antimalarial drug primaquine and their in vitro methemoglobin-producing and glutathione-depleting activity in human erythrocytes . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial drug",
"pos": [
46,
63
]
} | {
"id": "C0033126",
"name": "primaquine",
"pos": [
64,
74
]
} |
a number of hydroxy analogues of the antimalarial drug primaquine [ 8- [ ( 4-amino-1-methylbutyl ) amino ] -6-methoxyquinoline ] were synthesized and characterized by 1h nmr and mass spectra . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial",
"pos": [
37,
49
]
} | {
"id": "C0033126",
"name": "primaquine",
"pos": [
55,
65
]
} |
two new experimental antifungal azole drugs were compared with ketoconazole for the management of experimental murine coccidioidomycosis . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
21,
31
]
} | {
"id": "C0022625",
"name": "ketoconazole",
"pos": [
63,
75
]
} |
among salmonellae , the strains causing enteric fever have no animal reservoir and the few food poisoning incidents in man that require therapy can be treated with antibacterial agents such as trimethoprim . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial agents",
"pos": [
164,
184
]
} | {
"id": "C0041041",
"name": "trimethoprim",
"pos": [
193,
205
]
} |
the antiarrhythmic efficacy of moracizin hcl ( ethmozine ) , a new oral phenothiazine derivative , was evaluated in 20 patients with chronic high-frequency ventricular arrhythmia confirmed by multiple ambulatory electrocardiographic recordings . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
4,
18
]
} | {
"id": "C0724636",
"name": "moracizin hcl",
"pos": [
31,
44
]
} |
the antipsychotic drugs chlorpromazine , pimozide , and penfluridol caused a 50 % inhibition of growth of tetrahymena at concentrations of 4.5 , 5.5 , and 1.5 microm , respectively . | therapeutic_class_of | {
"id": "C0040615",
"name": "antipsychotic drugs",
"pos": [
4,
23
]
} | {
"id": "C0031935",
"name": "pimozide",
"pos": [
41,
49
]
} |
effects of ym-09151-2 and five other neuroleptics ( haloperidol , spiperone , chlorpromazine , sulpiride and clozapine ) on the binding of [ 3h ] -ligands to nine different receptors ( alpha 1-adrenergic , alpha 2-adrenergic , beta-adrenergic , muscarinic , d2-dopaminergic , h1-histaminergic , 5ht1-serotonergic , 5ht2-serotonergic and opiate receptors ) and on dopamine-sensitive adenylate cyclase were determined using brain membranes in the rat , guinea-pig and dog . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
37,
49
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
52,
63
]
} |
the effects of four antiarrhythmic drugs , quinidine , procainamide , amiodarone and verapamil were studied on sinus rate , conduction time and , when possible , effective refractory period ( erp ) in atrioventricular node ( av node ) , and finally atrial muscle erp . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
20,
34
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
43,
52
]
} |
the effects of four antiarrhythmic drugs , quinidine , procainamide , amiodarone and verapamil were studied on sinus rate , conduction time and , when possible , effective refractory period ( erp ) in atrioventricular node ( av node ) , and finally atrial muscle erp . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
20,
34
]
} | {
"id": "C0033216",
"name": "procainamide",
"pos": [
55,
67
]
} |
the effects of four antiarrhythmic drugs , quinidine , procainamide , amiodarone and verapamil were studied on sinus rate , conduction time and , when possible , effective refractory period ( erp ) in atrioventricular node ( av node ) , and finally atrial muscle erp . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
20,
34
]
} | {
"id": "C0002598",
"name": "amiodarone",
"pos": [
70,
80
]
} |
the effect of subcutaneously injected dt gamma e ( beta-endorphin , ( beta e ) 2-17 ) on the pineal melatonin level was compared with that of closely related peptides and the neuroleptic drug haloperidol . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic drug",
"pos": [
175,
191
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
192,
203
]
} |
the antidepressant properties of amineptine and imipramine were compared in a double-blind controlled trial involving 38 patients randomized to one or the other treatment . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
4,
18
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
48,
58
]
} |
similar results were obtained in 7 trials examining the antimanic property of the keto-derivative of carbamazepine ( oxcarbazepine ) in 6 patients with acute mania , whereas no antimanic effect could be observed in a treatment with diazepam and with thip . | therapeutic_class_of | {
"id": "C0242911",
"name": "antimanic",
"pos": [
56,
65
]
} | {
"id": "C0006949",
"name": "carbamazepine",
"pos": [
101,
114
]
} |
antidepressants ( amitriptylin , imipramine , ludiomil , alival ) at the concentrations present in the blood during treatment do not inhibit serotonin secretion by human blood platelets . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
0,
15
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
33,
43
]
} |
well established as supposed antidepressant drugs , desipramine ( 1.25-5 mg/kg ) , nisoxetine ( 0.625-2.5 mg/kg ) and clomipramine ( 1.25-5 mg/kg ) but not fluoxetine ( 2.5-40 mg/kg ) or citalopram ( 2.5-40 mg/kg ) dose-dependently potentiated trh ( 40 mg/kg ) -induced hyperthermia in mice . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant drugs",
"pos": [
29,
49
]
} | {
"id": "C0011685",
"name": "desipramine",
"pos": [
52,
63
]
} |
well established as supposed antidepressant drugs , desipramine ( 1.25-5 mg/kg ) , nisoxetine ( 0.625-2.5 mg/kg ) and clomipramine ( 1.25-5 mg/kg ) but not fluoxetine ( 2.5-40 mg/kg ) or citalopram ( 2.5-40 mg/kg ) dose-dependently potentiated trh ( 40 mg/kg ) -induced hyperthermia in mice . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant drugs",
"pos": [
29,
49
]
} | {
"id": "C0009010",
"name": "clomipramine",
"pos": [
118,
130
]
} |
behavioural evidence that chronic treatment with the antidepressant desipramine causes reduced functioning of brain noradrenaline systems . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
53,
67
]
} | {
"id": "C0011685",
"name": "desipramine",
"pos": [
68,
79
]
} |
increasing doses of apomorphine elicited polyphasic changes in locomotor activity in mice , consisting of : ( i ) hypokinesia with a peak effect at 25 micrograms/kg , which was not antagonized by various neuroleptics used at the highest doses not changing spontaneous locomotor activity , except for haloperidol ; | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
204,
216
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
300,
311
]
} |
combination antifungal chemotherapy for experimental disseminated candidiasis : lack of correlation between in vitro and in vivo observations with amphotericin b and rifampin . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
12,
22
]
} | {
"id": "C0002679",
"name": "amphotericin",
"pos": [
147,
159
]
} |
antimicrobial prophylaxis of travellers ' diarrhoea : a summary of studies using doxycycline or trimethoprim and sulphamethoxazole . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial",
"pos": [
0,
13
]
} | {
"id": "C0038689",
"name": "sulphamethoxazole",
"pos": [
113,
130
]
} |
antimicrobial therapy of travellers ' diarrhoea with doxycycline or a combination of trimethoprim and sulphamethoxazole is effective only while the drugs are being taken . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial",
"pos": [
0,
13
]
} | {
"id": "C0038689",
"name": "sulphamethoxazole",
"pos": [
102,
119
]
} |
use of the social behaviour assessment schedule ( sbas ) in a trial of maintenance antipsychotic therapy in schizophrenic outpatients : pimozide versus fluphenazine . | therapeutic_class_of | {
"id": "C0040615",
"name": "antipsychotic",
"pos": [
83,
96
]
} | {
"id": "C0031935",
"name": "pimozide",
"pos": [
136,
144
]
} |
the inhibitory activities of 2 new orally absorbed antifungal imidazole derivatives , bay n 7133 and bay 1 9139 , were compared in vitro with those of ketoconazole and miconazole . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
51,
61
]
} | {
"id": "C0022625",
"name": "ketoconazole",
"pos": [
151,
163
]
} |
the inhibitory activities of 2 new orally absorbed antifungal imidazole derivatives , bay n 7133 and bay 1 9139 , were compared in vitro with those of ketoconazole and miconazole . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
51,
61
]
} | {
"id": "C0025942",
"name": "miconazole",
"pos": [
168,
178
]
} |
two high-pressure liquid chromatography procedures are presented for the routine analysis of two new antidepressant drugs , amoxapine ( asendin ) as well as its active metabolite and maprotiline ( ludiomil ) . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
101,
115
]
} | {
"id": "C0002644",
"name": "amoxapine",
"pos": [
124,
133
]
} |
forty-five randomly selected children received prophylactic antimicrobial therapy ( sulfamethoxazole ) , and the remaining 39 children served as controls . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial",
"pos": [
60,
73
]
} | {
"id": "C0038689",
"name": "sulfamethoxazole",
"pos": [
84,
100
]
} |
this profile is typical for antidepressants of the desipramine type and was also observed in our present study after 150 mg nomifensine and ( although less markedly ) and 20 mg tranylcypromine . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
28,
43
]
} | {
"id": "C0011685",
"name": "desipramine",
"pos": [
51,
62
]
} |
these alterations were described previously as typical for antidepressants of the imipramine type , and were also noted after 75 mg imipramine in the present study . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
59,
74
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
132,
142
]
} |
the antibacterial effect of silver sulphadiazine is compared with that of zinc sulphadiazine in three in vitro tests with 14 different bacterial colonies . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0037134",
"name": "silver sulphadiazine",
"pos": [
28,
48
]
} |
nomifensine , an antidepressive agent acting like a dopamine agonist , was investigated in a randomized double-blind comparison with amitriptyline in 29 patients fulfilling the rdc criteria for major depression . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressive agent",
"pos": [
17,
37
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
133,
146
]
} |
susceptibility testing of 96 clinical group ive isolates to 19 antimicrobial agents by agar dilution revealed that , at drug levels achievable in serum , the isolates were susceptible only to aminoglycosides , cephalosporins , and colistin , whereas at drug concentrations attainable in urine , they were susceptible to erythromycin , tetracycline , and nitrofurantoin as well . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial",
"pos": [
63,
76
]
} | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
320,
332
]
} |
susceptibility testing of 96 clinical group ive isolates to 19 antimicrobial agents by agar dilution revealed that , at drug levels achievable in serum , the isolates were susceptible only to aminoglycosides , cephalosporins , and colistin , whereas at drug concentrations attainable in urine , they were susceptible to erythromycin , tetracycline , and nitrofurantoin as well . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial",
"pos": [
63,
76
]
} | {
"id": "C0039644",
"name": "tetracycline",
"pos": [
335,
347
]
} |
the antibacterial activity of the combination metronidazol with mezlocillin or oxacillin was exclusively determined by the penicillins used . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0029983",
"name": "oxacillin",
"pos": [
79,
88
]
} |
a positive antiarrhythmic effect of intravenous trimecain was observed in 35.3 % of the patients , that of pyromecain was in 18.2 % and after administration of a related compound lidocain , it was seen in 30.0 % and 26.7 % , respectively . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
11,
25
]
} | {
"id": "C0023660",
"name": "lidocain",
"pos": [
179,
187
]
} |
the antifungal activity of econazole-ornidazole combination ( ratio 1:10 ) has been evaluated against 90 strains of candida spp . recently isolated from a clinical environment . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
4,
14
]
} | {
"id": "C0013547",
"name": "econazole",
"pos": [
27,
36
]
} |
the effects of two antimalarial drugs , chloroquine and primaquine on antipyrine kinetics and metabolism have been studied in volunteers . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial",
"pos": [
19,
31
]
} | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
40,
51
]
} |
the effects of two antimalarial drugs , chloroquine and primaquine on antipyrine kinetics and metabolism have been studied in volunteers . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial",
"pos": [
19,
31
]
} | {
"id": "C0033126",
"name": "primaquine",
"pos": [
56,
66
]
} |
the antiarrhythmic efficacy of mexiletine was evaluated in 28 subjects with recurrent ventricular tachycardia or fibrillation ( 22 subjects ) or with symptomatic complex ventricular ectopy ( six subjects ) . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
4,
18
]
} | {
"id": "C0025887",
"name": "mexiletine",
"pos": [
31,
41
]
} |
the antibacterial activity of azlocillin and piperacillin in serum against staphylococcus aureus was slightly better than in broth ( p greater than 0.05 ) ; | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0031955",
"name": "piperacillin",
"pos": [
45,
57
]
} |
the antibacterial activity of azlocillin and piperacillin against both bacterial strains was most pronounced in the presence of leukocytes and serum . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0031955",
"name": "piperacillin",
"pos": [
45,
57
]
} |
the antibacterial interaction between ceftriaxone and the aminoglycosides tobramycin , gentamicin and amikacin against pseudomonas aeruginosa was investigated in vitro and in experimental systemic infections of the mouse . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0007561",
"name": "ceftriaxone",
"pos": [
38,
49
]
} |
the antibacterial interaction between ceftriaxone and the aminoglycosides tobramycin , gentamicin and amikacin against pseudomonas aeruginosa was investigated in vitro and in experimental systemic infections of the mouse . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0040341",
"name": "tobramycin",
"pos": [
74,
84
]
} |
the antibacterial interaction between ceftriaxone and the aminoglycosides tobramycin , gentamicin and amikacin against pseudomonas aeruginosa was investigated in vitro and in experimental systemic infections of the mouse . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0002499",
"name": "amikacin",
"pos": [
102,
110
]
} |
no other antibacterial agents were used except in four patients with brain abscesses , in whom ceftriaxone was combined with ornidazole . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial agents",
"pos": [
9,
29
]
} | {
"id": "C0007561",
"name": "ceftriaxone",
"pos": [
95,
106
]
} |
[ comparison of the anti-arrhythmic effects of propafenone and aprindine in the treatment of refractory chronic ventricular arrhythmias . a randomized double-blind crossover study controlled with placebo ] . | therapeutic_class_of | {
"id": "C0003195",
"name": "anti-arrhythmic",
"pos": [
20,
35
]
} | {
"id": "C0033429",
"name": "propafenone",
"pos": [
47,
58
]
} |
a placebo-controlled , randomized , double-blind , crossover study was performed in 14 patients with chronic , resistant , ventricular arrhythmias in order to evaluate the efficacy and safety of two new antiarrhythmic agents , propafenone and aprindine . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agents",
"pos": [
203,
224
]
} | {
"id": "C0033429",
"name": "propafenone",
"pos": [
227,
238
]
} |
the antibacterial activity of the cephalosporin antibiotic hr 810 was evaluated in comparison with cefoperazone , cefotaxime , ceftazidime , ceftriaxone , latamoxef , gentamicin and amikacin against 1500 clinical isolates . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0007552",
"name": "cefoperazone",
"pos": [
99,
111
]
} |
the antibacterial activity of the cephalosporin antibiotic hr 810 was evaluated in comparison with cefoperazone , cefotaxime , ceftazidime , ceftriaxone , latamoxef , gentamicin and amikacin against 1500 clinical isolates . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
114,
124
]
} |
the antibacterial activity of the cephalosporin antibiotic hr 810 was evaluated in comparison with cefoperazone , cefotaxime , ceftazidime , ceftriaxone , latamoxef , gentamicin and amikacin against 1500 clinical isolates . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0007559",
"name": "ceftazidime",
"pos": [
127,
138
]
} |
the antibacterial activity of the cephalosporin antibiotic hr 810 was evaluated in comparison with cefoperazone , cefotaxime , ceftazidime , ceftriaxone , latamoxef , gentamicin and amikacin against 1500 clinical isolates . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0007561",
"name": "ceftriaxone",
"pos": [
141,
152
]
} |
the antibacterial activity of the cephalosporin antibiotic hr 810 was evaluated in comparison with cefoperazone , cefotaxime , ceftazidime , ceftriaxone , latamoxef , gentamicin and amikacin against 1500 clinical isolates . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0002499",
"name": "amikacin",
"pos": [
182,
190
]
} |
patients with less than 1000 granulocytes and fever above 38.5 degrees c were included in this empirical antibacterial protocol ( 15 mg amikacin/kg/day/iv , 500 mg carbenicillin/kg/day/iv , 200 mg cefoxitin/kg/day/iv ) . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
105,
118
]
} | {
"id": "C0002499",
"name": "amikacin",
"pos": [
136,
144
]
} |
patients with less than 1000 granulocytes and fever above 38.5 degrees c were included in this empirical antibacterial protocol ( 15 mg amikacin/kg/day/iv , 500 mg carbenicillin/kg/day/iv , 200 mg cefoxitin/kg/day/iv ) . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
105,
118
]
} | {
"id": "C0006976",
"name": "carbenicillin",
"pos": [
164,
177
]
} |
patients with less than 1000 granulocytes and fever above 38.5 degrees c were included in this empirical antibacterial protocol ( 15 mg amikacin/kg/day/iv , 500 mg carbenicillin/kg/day/iv , 200 mg cefoxitin/kg/day/iv ) . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
105,
118
]
} | {
"id": "C0007557",
"name": "cefoxitin",
"pos": [
197,
206
]
} |
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