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it is based on the clinical experience when three systemic antifungal drugs ( griseofulvin , thiabendazole , and ketoconazole ) are used against onychomycosis . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal drugs",
"pos": [
59,
75
]
} | {
"id": "C0022625",
"name": "ketoconazole",
"pos": [
113,
125
]
} |
it was found that daily treatment during a period of 10 days with 6 mg/kg body weight , given as medicated feed , resulted in a decreased fecal larval count at the 10th day and a total cessation of excretion of larvae at the 43rd day , indicating a good anthelmintic effect of mebendazole on e. rangiferi . | therapeutic_class_of | {
"id": "C0003158",
"name": "anthelmintic",
"pos": [
254,
266
]
} | {
"id": "C0025023",
"name": "mebendazole",
"pos": [
277,
288
]
} |
field results from a commercial goat herd , based on egg counts and larval differentiation , suggested that anthelmintic resistance was present to albendazole , fenbendazole , levamisole , morantel , naphthalophos and phenothiazine . | therapeutic_class_of | {
"id": "C0003158",
"name": "anthelmintic",
"pos": [
108,
120
]
} | {
"id": "C0001911",
"name": "albendazole",
"pos": [
147,
158
]
} |
ten healthy volunteers participated in a double-blind controlled , randomized , cross-over trial , where the effects of the antidepressant drugs imipramine ( 75 mg/day ) and zimelidine ( 100 mg/day and 200 mg/day ) on saliva secretion rate and saliva composition were tested . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
124,
138
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
145,
155
]
} |
the relative antibacterial efficacy of amoxycillin ampicillin was compared in vitro and in vivo against a strain of escherichia coli in short-term experiments ( hours ) . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
13,
26
]
} | {
"id": "C0002645",
"name": "amoxycillin",
"pos": [
39,
50
]
} |
the relative antibacterial efficacy of amoxycillin ampicillin was compared in vitro and in vivo against a strain of escherichia coli in short-term experiments ( hours ) . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
13,
26
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
51,
61
]
} |
in order to understand the role of d1 and d2 receptors in the antipsychotic action of neuroleptics , we have performed subchronic treatment with haloperidol , a drug which acts on d1 receptors , and sulpiride , a selective antagonist to d2 receptors . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
86,
98
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
145,
156
]
} |
in 36 female inpatients with vital depression , the antidepressant properties of fluvoxamine and clomipramine were studied . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
52,
66
]
} | {
"id": "C0009010",
"name": "clomipramine",
"pos": [
97,
109
]
} |
although piperacillin has a wider in vitro antibacterial spectrum than ticarcillin , the clinical efficacy and toxicity of the combination of piperacillin plus amikacin were similar to those of ticarcillin plus amikacin as empiric therapy . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
43,
56
]
} | {
"id": "C0031955",
"name": "piperacillin",
"pos": [
142,
154
]
} |
although piperacillin has a wider in vitro antibacterial spectrum than ticarcillin , the clinical efficacy and toxicity of the combination of piperacillin plus amikacin were similar to those of ticarcillin plus amikacin as empiric therapy . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
43,
56
]
} | {
"id": "C0040193",
"name": "ticarcillin",
"pos": [
194,
205
]
} |
although piperacillin has a wider in vitro antibacterial spectrum than ticarcillin , the clinical efficacy and toxicity of the combination of piperacillin plus amikacin were similar to those of ticarcillin plus amikacin as empiric therapy . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
43,
56
]
} | {
"id": "C0002499",
"name": "amikacin",
"pos": [
211,
219
]
} |
it must be concluded that , in man , lorcainide produces electrophysiological effects of antiarrhythmic agents of the quinidine type . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agents",
"pos": [
89,
110
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
118,
127
]
} |
since there is an excellent correlation between the relative potencies of a series of antidepressants in displacing 3h-imipramine from binding sites in human brain and platelet , we have examined the binding of 3h-imipramine to platelets from 14 depressed patients and 28 age- and sex-matched controls . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
86,
101
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
214,
224
]
} |
effect of the antidepressants of different chemical groups -- imipramine , desmethylimipramine , chlorimipramine , befuralin , trazodon , pyrazidol , inkasan and azaphen -- on the uptake of 3h-serotonin and 3h-gaba by the crude synaptosomal fraction of the rat brain was studied . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
14,
29
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
102,
112
]
} |
effect of the antidepressants of different chemical groups -- imipramine , desmethylimipramine , chlorimipramine , befuralin , trazodon , pyrazidol , inkasan and azaphen -- on the uptake of 3h-serotonin and 3h-gaba by the crude synaptosomal fraction of the rat brain was studied . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
14,
29
]
} | {
"id": "C0011685",
"name": "desmethylimipramine",
"pos": [
75,
94
]
} |
effect of the antidepressants of different chemical groups -- imipramine , desmethylimipramine , chlorimipramine , befuralin , trazodon , pyrazidol , inkasan and azaphen -- on the uptake of 3h-serotonin and 3h-gaba by the crude synaptosomal fraction of the rat brain was studied . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
14,
29
]
} | {
"id": "C0009010",
"name": "chlorimipramine",
"pos": [
97,
112
]
} |
we report here a novel high pressure liquid chromatographic ( hplc ) technique for use in therapeutic monitoring of the primary amine antiarrhythmic drug mexiletine in plasma samples . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
134,
148
]
} | {
"id": "C0025887",
"name": "mexiletine",
"pos": [
154,
164
]
} |
a new antiseptic contrast material , composed of sodium diatrizoate-meglumine diatrizoate and pvp-iodine solution , was prepared and tested for retrograde cystography . | therapeutic_class_of | {
"id": "C0003205",
"name": "antiseptic",
"pos": [
6,
16
]
} | {
"id": "C0032857",
"name": "pvp-iodine",
"pos": [
94,
104
]
} |
a comparative randomized study was designed to evaluate the prophylactic effect of two different combinations of antimicrobials , i.e . metronidazole-fosfomycin ( n = 30 ) and metronidazole-cephalothin ( n = 28 ) , in elective colorectal surgery . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobials",
"pos": [
113,
127
]
} | {
"id": "C0025872",
"name": "metronidazole",
"pos": [
176,
189
]
} |
thirty adult horses were used to compare the toxicity and cholinesterase ( che ) inhibition of various dosages of a combination anthelmintic , trichlorfon + mebendazole . | therapeutic_class_of | {
"id": "C0003158",
"name": "anthelmintic",
"pos": [
128,
140
]
} | {
"id": "C0025023",
"name": "mebendazole",
"pos": [
157,
168
]
} |
we investigated a number of parameters for host defense after the in vitro addition of the antifungal agents ketoconazole , amphotericin b ( amb ) , and amphotericin b methyl ester ( ame ) . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal agents",
"pos": [
91,
108
]
} | {
"id": "C0022625",
"name": "ketoconazole",
"pos": [
109,
121
]
} |
we investigated a number of parameters for host defense after the in vitro addition of the antifungal agents ketoconazole , amphotericin b ( amb ) , and amphotericin b methyl ester ( ame ) . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal agents",
"pos": [
91,
108
]
} | {
"id": "C0002679",
"name": "amphotericin b",
"pos": [
153,
167
]
} |
a large-scale research programme in the united states of america in the 1940s produced three new antimalarial drugs-pentaquine , isopentaquine , and primaquine -of which primaquine was the most effective . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial",
"pos": [
97,
109
]
} | {
"id": "C0033126",
"name": "primaquine",
"pos": [
170,
180
]
} |
the electrophysiologic effects of the antiarrhythmic agent disopyramide phosphate given intravenously were studied in 10 patients with cardiac disease . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agent",
"pos": [
38,
58
]
} | {
"id": "C0700534",
"name": "disopyramide",
"pos": [
59,
71
]
} |
although this study does not elucidate the mechanism by which disopyramide acheives its antiarrhythmic effects , animal work has shown that it is similar to that of quinidine . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
88,
102
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
165,
174
]
} |
compared to procainamide in an animal arrhythmic model , the antiarrhythmic potency of the n-acetylated metabolite of procainamide ( napa ) was 92 % with respect to dose and 70 % with respect to plasma level . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
61,
75
]
} | {
"id": "C0033216",
"name": "procainamide",
"pos": [
118,
130
]
} |
plasma levels of gx have 26 % the antiarrhythmic activity of lidocaine in an animal model , and gx adversely affects the mental performance of normal subjects at plasma concentrations comparable to those found in patients . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
34,
48
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
61,
70
]
} |
the administration of l-dopa , 100 mg/kg i.p. , after inhibition of peripheral dopa decarboxylase , disrupts the discrimination but not the acoidance behaviour , whereas the administration of the antipsychotic agent haloperidol ( hpd ) , 0.125 mg/kg i.p. , disrupts the avoidance behaviour but not the discrimination . | therapeutic_class_of | {
"id": "C0040615",
"name": "antipsychotic agent",
"pos": [
196,
215
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
216,
227
]
} |
the present data show that administration of the antipsychotic agent hpd not only inhibits behaviour but also can improve the behaviour in animals with a disturbed function . | therapeutic_class_of | {
"id": "C0040615",
"name": "antipsychotic agent",
"pos": [
49,
68
]
} | {
"id": "C0018546",
"name": "hpd",
"pos": [
69,
72
]
} |
the antifungal activity of miconazole on c. albicans was inversely proportional to the number of cells inoculated in the media . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
4,
14
]
} | {
"id": "C0025942",
"name": "miconazole",
"pos": [
27,
37
]
} |
comparative effects of the antidepressant drug , amitriptyline hydrochloride , marital therapy , and the drug-psychotherapy interaction effects were studied in a 12-week course of treatment of outpatient depressives . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
27,
41
]
} | {
"id": "C0700523",
"name": "amitriptyline hydrochloride",
"pos": [
49,
76
]
} |
the antibacterial spectrum and level of activity of amoxycillin is essentially the same as for ampicillin , and there is complete cross-resistance between the two drugs . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0002645",
"name": "amoxycillin",
"pos": [
52,
63
]
} |
the antibacterial spectrum and level of activity of amoxycillin is essentially the same as for ampicillin , and there is complete cross-resistance between the two drugs . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
95,
105
]
} |
rats were given either the tyrosine hydroxylase inhibitor , alpha-methyltyrosine ( alphamt ) , in doses of 10 or 250 mg/kg or the neuroleptic , haloperidol ( 0.25 mg/kg ) . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
130,
141
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
144,
155
]
} |
effect of particle size on the anthelmintic efficacy of mebendazole against nippostrongylus brasiliensis in the rat . | therapeutic_class_of | {
"id": "C0003158",
"name": "anthelmintic",
"pos": [
31,
43
]
} | {
"id": "C0025023",
"name": "mebendazole",
"pos": [
56,
67
]
} |
in vitro antibacterial activity of amikacin , a new aminoglycoside , against clinical bacterial isolates from children . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
9,
22
]
} | {
"id": "C0002499",
"name": "amikacin",
"pos": [
35,
43
]
} |
tolerance phenomena with neuroleptics catalepsy , apomorphine stereotypies and striatal dopamine metabolism in the rat after single and repeated administration of loxapine and haloperidol . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
25,
37
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
176,
187
]
} |
dynamics of the antibacterial activity of blood serum and bile following administration of trimethoprim and sulphamethoxazol . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
16,
29
]
} | {
"id": "C0041041",
"name": "trimethoprim",
"pos": [
91,
103
]
} |
most of the carbapenems potentiated the antibacterial activities of ampicillin and cefotiam against beta-lactamase-producing bacteria . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
40,
53
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
68,
78
]
} |
comparative study of the antibacterial activity of amikacin and tobramycin during pseudomonas pulmonary infection in patients with cystic fibrosis . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
25,
38
]
} | {
"id": "C0002499",
"name": "amikacin",
"pos": [
51,
59
]
} |
comparative study of the antibacterial activity of amikacin and tobramycin during pseudomonas pulmonary infection in patients with cystic fibrosis . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
25,
38
]
} | {
"id": "C0040341",
"name": "tobramycin",
"pos": [
64,
74
]
} |
the most controversial areas are the possibility of renal toxicity and the concomitant use of lithium with neuroleptics , especially haloperidol . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
107,
119
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
133,
144
]
} |
the correction factors to express the results of hplc in terms of antimicrobial bioequivalency against staphylococcus aureus tcc 6538p for erythromycins a , b , and c were determined to be 1.0 , 0.92 , and 0.48 , respectively . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial",
"pos": [
66,
79
]
} | {
"id": "C0014806",
"name": "erythromycins",
"pos": [
139,
152
]
} |
the concentrations of disopyramide and phenytoin were almost the same as those reported for human antiarrhythmic concentrations , but those of procainamide were higher than those reported for man . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
98,
112
]
} | {
"id": "C0033216",
"name": "procainamide",
"pos": [
143,
155
]
} |
an in vitro study indicated that certain antacids and adsorbents may decrease the oral availability of th two widely used antimalarial agents chloroquine and pyrimethamine . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial agents",
"pos": [
122,
141
]
} | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
142,
153
]
} |
to determine if this data was applicable to the clinical ( in vivo ) situation , plasma levels of one of the antimalarial agents ( chloroquine ) were followed in six negro -- arab volunteers both when given alone and when taken with separate doses of two of the implicated interactants ( magnesium trisilicate and kaolin ) . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial agents",
"pos": [
109,
128
]
} | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
131,
142
]
} |
ctm showed antibacterial activity , in terms of mic , as strong as those of cephalothin ( cet ) and cefazolin ( cez ) for gram-positive cocci , and several times superior to for gram-negative bacilli . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
11,
24
]
} | {
"id": "C0007546",
"name": "cefazolin",
"pos": [
100,
109
]
} |
in addition , the antibacterial activity of ntl was found to be stronger than that of gm and stronger than that of cez for those resistant strains and especially for those moderately resistant to gm . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
18,
31
]
} | {
"id": "C0007546",
"name": "cez",
"pos": [
115,
118
]
} |
the effect of 4 to 6 weeks of treatment with the antidepressants , desmethylimipramine and amitriptyline , on the growth hormone response to clonidine was studied in 12 depressed patients . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
49,
64
]
} | {
"id": "C0011685",
"name": "desmethylimipramine",
"pos": [
67,
86
]
} |
the effect of 4 to 6 weeks of treatment with the antidepressants , desmethylimipramine and amitriptyline , on the growth hormone response to clonidine was studied in 12 depressed patients . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
49,
64
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
91,
104
]
} |
this review compares and contrasts the preclinical pharmacology of bromperidol with another butyrophenone neuroleptic , haloperidol , and the phenothiazine neuroleptic chlorpromazine . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
106,
117
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
120,
131
]
} |
the anthelmintic activity of albendazole ( 5 mg/kg ) and cambendazole ( 20 mg/kg ) was compared in twenty-two naturally infected horses and ponies , which were divided into two equal groups . | therapeutic_class_of | {
"id": "C0003158",
"name": "anthelmintic",
"pos": [
4,
16
]
} | {
"id": "C0001911",
"name": "albendazole",
"pos": [
29,
40
]
} |
the effect of dopaminomimetics ( apomorphine , piribedil , bromocriptine ) , cholinomimetics ( oxotremorine , arecoline , pylocarpine ) , and neuroleptics ( chlorpromazine , haloperidol , triperidol ) on rectal temperature ( tr ) and temperature of different parts of the skin has been investigated in albino mice and rats of either sex . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
142,
154
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
174,
185
]
} |
the relationship of desipramine hydrochloride plasma concentration and antidepressant response was determined in 30 depressed inpatients treated for three weeks with desipramine . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
71,
85
]
} | {
"id": "C0011685",
"name": "desipramine",
"pos": [
166,
177
]
} |
treatment of rats infected with nippostrongylus brasiliensis with a single , oral therapeutic dose of the anthelmintic benzimidazole carbamates oxfendazole or mebendazole resulted , 24 hr later , in a marked reduction ( 60-90 % ) in the secretion of a low molecular weight acetylcholinesterase from the parasites when they were incubated in vitro . | therapeutic_class_of | {
"id": "C0003158",
"name": "anthelmintic",
"pos": [
106,
118
]
} | {
"id": "C0025023",
"name": "mebendazole",
"pos": [
159,
170
]
} |
the results indicate that the new antiarrhythmic drug flecainide possesses two different sites of action , indicated by the different frequency dependence on vmax and slow potential system under flecainide . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drug",
"pos": [
34,
53
]
} | {
"id": "C0016229",
"name": "flecainide",
"pos": [
195,
205
]
} |
the effect of an antiarrhythmic drug , quinidine , on the organization of model phospholipid membranes was studied by the spin-labeling technique . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
17,
31
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
39,
48
]
} |
adverse reactions to various antibacterial drugs were compared in a review of the following : multiple-dose studies of cefotaxime ( n = 3,463 ) , cefazolin ( n = 554 ) , the combination gentamicin-clindamycin ( n = 163 ) , and cefoxitin ( n = 18 ) ; | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
29,
42
]
} | {
"id": "C0007546",
"name": "cefazolin",
"pos": [
146,
155
]
} |
adverse reactions to various antibacterial drugs were compared in a review of the following : multiple-dose studies of cefotaxime ( n = 3,463 ) , cefazolin ( n = 554 ) , the combination gentamicin-clindamycin ( n = 163 ) , and cefoxitin ( n = 18 ) ; | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
29,
42
]
} | {
"id": "C0008947",
"name": "clindamycin",
"pos": [
197,
208
]
} |
adverse reactions to various antibacterial drugs were compared in a review of the following : multiple-dose studies of cefotaxime ( n = 3,463 ) , cefazolin ( n = 554 ) , the combination gentamicin-clindamycin ( n = 163 ) , and cefoxitin ( n = 18 ) ; | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
29,
42
]
} | {
"id": "C0007557",
"name": "cefoxitin",
"pos": [
227,
236
]
} |
to study the effects of enzyme induction on its pharmacokinetics , a single oral dose of the new antiarrhythmic agent mexiletine hydrochloride 400 mg was administered to 8 healthy volunteers before and after treatment with rifampicin 300 mg b.i.d . for ten days . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agent",
"pos": [
97,
117
]
} | {
"id": "C0543459",
"name": "mexiletine hydrochloride",
"pos": [
118,
142
]
} |
these results indicate that up 614-04 has a behavioral profile that is consistent with an antidepressant action , but that it differs from imipramine and viloxazine . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
90,
104
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
139,
149
]
} |
the major sleep characteristics of depression are summarized and new eeg sleep studies of antidepressants , including preliminary data on desipramine and zimelidine , are described . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
90,
105
]
} | {
"id": "C0011685",
"name": "desipramine",
"pos": [
138,
149
]
} |
effects of anti-epileptic drug treatment with carbamazepine or phenytoin on the oral state of children and adolescents . | therapeutic_class_of | {
"id": "C0003299",
"name": "anti-epileptic",
"pos": [
11,
25
]
} | {
"id": "C0031507",
"name": "phenytoin",
"pos": [
63,
72
]
} |
evidence for in vivo methylation of the secondary amino antidepressant desipramine to imipramine in humans . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
56,
70
]
} | {
"id": "C0011685",
"name": "desipramine",
"pos": [
71,
82
]
} |
evidence for in vivo methylation of the secondary amino antidepressant desipramine to imipramine in humans . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
56,
70
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
86,
96
]
} |
the antimalarial drug , chloroquine , is extensively distributed in tissue and slowly eliminated such that after a single dose , a plasma half-life of 3-5 days has been found ( mcchesney & mcauliff 1961 ; mcchesney et al 1967 ) . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial drug",
"pos": [
4,
21
]
} | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
24,
35
]
} |
the pharmacokinetics of the widely used antiarrhythmic agent , procainamide , was studied in rats with extrahepatic biliary obstruction produced by ligation of the common bile duct . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agent",
"pos": [
40,
60
]
} | {
"id": "C0033216",
"name": "procainamide",
"pos": [
63,
75
]
} |
evaluation of the total material after 6 weeks of nt treatment demonstrated a strong correlation of high plasma level to poor antidepressive effect of nt . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressive",
"pos": [
126,
140
]
} | {
"id": "C0028420",
"name": "nt",
"pos": [
151,
153
]
} |
antiarrhythmic and hemodynamic effects of i.v . disopyramide phosphate ( 1.7 mg/kg b.wt . over 2 min ) have been studied in nine patients , several in various degrees of cardiac decompensation , with sinus rhythm and persistent ventricular ectopic beats ( vebs ) . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
0,
14
]
} | {
"id": "C0700534",
"name": "disopyramide phosphate",
"pos": [
48,
70
]
} |
the quantitative effectiveness of antipsychotic drugs is also important in evaluating new agents and therefore relevant to a discussion of two newly released neuroleptics , molindone and loxapine . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
158,
170
]
} | {
"id": "C0026388",
"name": "molindone",
"pos": [
173,
182
]
} |
the antifungal activity of amphotericin b is abolished by heating serum at 100 c for 45 min . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
4,
14
]
} | {
"id": "C0002679",
"name": "amphotericin b",
"pos": [
27,
41
]
} |
the in vitro antibacterial effects of cefoxitin , a semisynthetic cephamycin , cefuroxime , a new cephalosporin antibiotic , and cephaloridine were compared . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
13,
26
]
} | {
"id": "C0007557",
"name": "cefoxitin",
"pos": [
38,
47
]
} |
the in vitro antibacterial effects of cefoxitin , a semisynthetic cephamycin , cefuroxime , a new cephalosporin antibiotic , and cephaloridine were compared . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
13,
26
]
} | {
"id": "C0007562",
"name": "cefuroxime",
"pos": [
79,
89
]
} |
this stability , although no absolute in all cases , has the effect of widening the antibacterial spectrum of the compound so that many organisms resistant to the established cephalosporins are susceptible to cefuroxime . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
84,
97
]
} | {
"id": "C0007562",
"name": "cefuroxime",
"pos": [
209,
219
]
} |
we deduce from these results for antiarrhythmic therapy on normokalemic patients , that the addition of potassium and magnesium to lidocaine solution does not enhance its antifibrillatory effect . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
33,
47
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
131,
140
]
} |
4 other antipsychotic drugs ( haloperidol , chlorpromazine , thioridazine ) or other agents ( propranolol , atropine ) did not share this action of clozapine . | therapeutic_class_of | {
"id": "C0040615",
"name": "antipsychotic drugs",
"pos": [
8,
27
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
30,
41
]
} |
the relationship between the antidepressive effect of imipramine and the plasma concentrations of imipramine and the active metabolite desipramine was studied in 24 patients suffering from endogenous depression . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressive",
"pos": [
29,
43
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
98,
108
]
} |
the relationship between the antidepressive effect of imipramine and the plasma concentrations of imipramine and the active metabolite desipramine was studied in 24 patients suffering from endogenous depression . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressive",
"pos": [
29,
43
]
} | {
"id": "C0011685",
"name": "desipramine",
"pos": [
135,
146
]
} |
the association of clomipramine plus lithium carbonate has no greater global antidepressive efficacy as compared with clomipramine plus placebo which means that lithium does not potentialize nor antagonize the anti depressant effect of clomipramine . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressive",
"pos": [
77,
91
]
} | {
"id": "C0009010",
"name": "clomipramine",
"pos": [
236,
248
]
} |
the effect of the neuroleptic pimozide at doses of 2 mg/day was compared with that of diazepam at doses of 3 x 5 mg . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
18,
29
]
} | {
"id": "C0031935",
"name": "pimozide",
"pos": [
30,
38
]
} |
the degree of antibacterial activity of the serum of the patients receiving amikacin was found to be related to the outcome . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
14,
27
]
} | {
"id": "C0002499",
"name": "amikacin",
"pos": [
76,
84
]
} |
correlation of the electrophysiological and antiarrhythmic properties of the n-acetyl metabolite of procainamide with plasma and tissue drug concentrations in the dog . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
44,
58
]
} | {
"id": "C0033216",
"name": "procainamide",
"pos": [
100,
112
]
} |
the present study compares the electrophysiological and antiarrhythmic effects of napa and pa and correlates their activity with plasma and tissue drug concentrations . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
56,
70
]
} | {
"id": "C0033216",
"name": "pa",
"pos": [
91,
93
]
} |
the neuroleptic compound haloperidol ( 0.5 mg/kg ) caused a fourfold increase in striatal hva content making it twice as efficient as narcotic analgesics . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
4,
15
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
25,
36
]
} |
the antiarrhythmic action of disopyramide phosphate was compared to placebo in a randomized double blind trial at rest and under physical exertion in two groups each of 10 patients with extrasystoles . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
4,
18
]
} | {
"id": "C0700534",
"name": "disopyramide phosphate",
"pos": [
29,
51
]
} |
[ comparative studies on the contractile and hemodynamic effects of antiarrhythmic agents ( lidocaine , diphenylhydantoin , ajmaline ) ( author 's transl ) ] . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agents",
"pos": [
68,
89
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
92,
101
]
} |
[ effects of streptomycin sulfate & streptomycin glucuronate on the functional behavior & morphological appearance of the cochleovestibular apparatus & findings on the antibacterial activity of the two salts in vivo . i. problem of the neurotoxic effects of streptomycin in its clinical , anatomicopathological , experimental , & therapeutic aspects ; summation of experimental research ] . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
168,
181
]
} | {
"id": "C0038425",
"name": "streptomycin",
"pos": [
258,
270
]
} |
[ iii . comparative study between the in vitro antibacterial activity of streptomycin sulfate & streptomycin glucuronate , with observations on the acute toxicity ( ld 50 ) & on hematic absorption of the two salts ] . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
47,
60
]
} | {
"id": "C0038426",
"name": "streptomycin sulfate",
"pos": [
73,
93
]
} |
[ iv . comparative study between the antibacterial activity in vivo of streptomycin sulfate & streptomycin glucuronate ] . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
37,
50
]
} | {
"id": "C0038426",
"name": "streptomycin sulfate",
"pos": [
71,
91
]
} |
three antimalarial drugs amodiaquine , quinacrine and chloroquine were compared side-by-side with the antiseptic agent chlorhexidine and the neuromuscular blocker alcuronium for their capacity to competitively inhibit in vitro the activity of the enzyme histamine n-methyltransferase ( hmt ) from rat kidney over the concentration range 10 ( -3 ) -10 ( -8 ) . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial drugs",
"pos": [
6,
24
]
} | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
54,
65
]
} |
thus fluconazole has a lower propensity to interact with rat hepatic cytochrome p-450 and can be considered a more selective antifungal agent as its in vivo antifungal potency is an order of magnitude greater than ketoconazole . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal agent",
"pos": [
125,
141
]
} | {
"id": "C0022625",
"name": "ketoconazole",
"pos": [
214,
226
]
} |
of the three agents , only procainamide exhibited antiarrhythmic action whereas lidocaine and acetylstrophanthidin produced inconsistent effects . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
50,
64
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
80,
89
]
} |
the effects of the intravenously administered antidepressant drugs mianserin , imipramine , metapramine , nomifensine and amineptine against ischaemia and reperfusion arrhythmias were investigated in anaesthetized rats . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
46,
60
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
79,
89
]
} |
using the mouse , photoallergy to the antiarrhythmic agent quinidine could be induced following systemic administration . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agent",
"pos": [
38,
58
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
59,
68
]
} |
the antiarrhythmic agent amiodarone is associated with numerous adverse effects , but clinically significant liver disease is rare . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agent",
"pos": [
4,
24
]
} | {
"id": "C0002598",
"name": "amiodarone",
"pos": [
25,
35
]
} |
effect of antiarrhythmic drugs on defibrillation threshold : case report of an adverse effect of mexiletine and review of the literature . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
10,
24
]
} | {
"id": "C0025887",
"name": "mexiletine",
"pos": [
97,
107
]
} |
humans treated with the antiarrhythmic drug amiodarone may develop pulmonary toxicity accompanied by the presence of alveolar macrophages ( am ) containing lamellar inclusions . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drug",
"pos": [
24,
43
]
} | {
"id": "C0002598",
"name": "amiodarone",
"pos": [
44,
54
]
} |
in a population with a low incidence of spontaneous arrhythmias , however , there was only a modest difference in antiarrhythmic efficacy between atenolol and sotalol . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
114,
128
]
} | {
"id": "C0037707",
"name": "sotalol",
"pos": [
159,
166
]
} |
quantitative structure activity studies of antiarrhythmic properties in a series of lidocaine and procainamide derivatives . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
43,
57
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
84,
93
]
} |
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