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quantitative structure activity studies of antiarrhythmic properties in a series of lidocaine and procainamide derivatives . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
43,
57
]
} | {
"id": "C0033216",
"name": "procainamide",
"pos": [
98,
110
]
} |
nystatin , given orally as a 'swish and swallow ' or mixed 1:1 with either silver sulfadiazine or polymyxin b/bacitracin , has eradicated candida burn wound infections and septicemia from this institution and thus obviated the need for systemic antifungals such as amphotericin b . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungals",
"pos": [
245,
256
]
} | {
"id": "C0002679",
"name": "amphotericin b",
"pos": [
265,
279
]
} |
aromatase activity of human placental microsomes was inhibited competitively by the antimalarial drug , mefloquine , but not by the related drug , chloroquine . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial drug",
"pos": [
84,
101
]
} | {
"id": "C0025153",
"name": "mefloquine",
"pos": [
104,
114
]
} |
aromatase activity of human placental microsomes was inhibited competitively by the antimalarial drug , mefloquine , but not by the related drug , chloroquine . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial drug",
"pos": [
84,
101
]
} | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
147,
158
]
} |
the antifungal drug , ketoconazole , was reported to antagonize the induction of the enzyme tyrosine aminotransferase ( tat ) by glucocorticoids in hepatoma tissue culture ( htc ) cells , and to compete with glucocorticoids for binding to the glucocorticoid receptor . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal drug",
"pos": [
4,
19
]
} | {
"id": "C0022625",
"name": "ketoconazole",
"pos": [
22,
34
]
} |
the effects of repeated treatment ( 21 days ) with different antipsychotic compounds ( haloperidol , clozapine , thioridazine and tefludazine ) on dopamine ( da ) neurones in substantia nigra pars compacta ( snc ) and ventral tegmental area ( vta ) were studied in rats using single unit recording techniques . | therapeutic_class_of | {
"id": "C0040615",
"name": "antipsychotic",
"pos": [
61,
74
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
87,
98
]
} |
the nonneuroleptic phenothiazine promethazine ( as well as the narcotic morphine , the muscle relaxant diazepam and the antidepressant desipramine ) were ineffective in this respect ( criterion 2 ) ; | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
120,
134
]
} | {
"id": "C0011685",
"name": "desipramine",
"pos": [
135,
146
]
} |
terbinafine , a new antifungal agent derived from allylamine , effective by oral route , was tested against 32 different strains of aspergilli to determine its in vitro efficiency compared with amphotericin b , 5-fluorocytosine and ketoconazole . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal agent",
"pos": [
20,
36
]
} | {
"id": "C0002679",
"name": "amphotericin b",
"pos": [
194,
208
]
} |
terbinafine , a new antifungal agent derived from allylamine , effective by oral route , was tested against 32 different strains of aspergilli to determine its in vitro efficiency compared with amphotericin b , 5-fluorocytosine and ketoconazole . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal agent",
"pos": [
20,
36
]
} | {
"id": "C0016278",
"name": "5-fluorocytosine",
"pos": [
211,
227
]
} |
terbinafine , a new antifungal agent derived from allylamine , effective by oral route , was tested against 32 different strains of aspergilli to determine its in vitro efficiency compared with amphotericin b , 5-fluorocytosine and ketoconazole . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal agent",
"pos": [
20,
36
]
} | {
"id": "C0022625",
"name": "ketoconazole",
"pos": [
232,
244
]
} |
antifungal sensitivity was determine by the mic method in liquid and solid mediums ( sabouraud , casitone , yma , ymb , ynb ) : with mic between 0.005 and 5 micrograms/ml , whatever the species and the techniques , terbinafine is more efficient than amphotericin b , ketoconazole ( 0.5 to 100 micrograms/ml ) and 5-fc ( 1-greater than 100 micrograms/ml ) . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
0,
10
]
} | {
"id": "C0002679",
"name": "amphotericin b",
"pos": [
250,
264
]
} |
antifungal sensitivity was determine by the mic method in liquid and solid mediums ( sabouraud , casitone , yma , ymb , ynb ) : with mic between 0.005 and 5 micrograms/ml , whatever the species and the techniques , terbinafine is more efficient than amphotericin b , ketoconazole ( 0.5 to 100 micrograms/ml ) and 5-fc ( 1-greater than 100 micrograms/ml ) . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
0,
10
]
} | {
"id": "C0022625",
"name": "ketoconazole",
"pos": [
267,
279
]
} |
antifungal sensitivity was determine by the mic method in liquid and solid mediums ( sabouraud , casitone , yma , ymb , ynb ) : with mic between 0.005 and 5 micrograms/ml , whatever the species and the techniques , terbinafine is more efficient than amphotericin b , ketoconazole ( 0.5 to 100 micrograms/ml ) and 5-fc ( 1-greater than 100 micrograms/ml ) . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
0,
10
]
} | {
"id": "C0016278",
"name": "5-fc",
"pos": [
313,
317
]
} |
the prevalence of rashes ranges from approximately 2 % to 4 % but is higher for certain antidepressants such as maprotiline and carbamazepine . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
88,
103
]
} | {
"id": "C0006949",
"name": "carbamazepine",
"pos": [
128,
141
]
} |
the in vitro activity of dihydromycoplanecin a ( dhmp a ) , a new cyclic peptide antibiotic , was compared with those of antimycobacterial drugs such as streptomycin , isoniazid ( inh ) , rifampin , and ofloxacin against several clinically isolated species of mycobacteria , including mycobacterium tuberculosis , m. intracellulare , and m. kansasii . | therapeutic_class_of | {
"id": "C0360390",
"name": "antimycobacterial",
"pos": [
121,
138
]
} | {
"id": "C0038425",
"name": "streptomycin",
"pos": [
153,
165
]
} |
the effect of five antimycobacterial drugs isoniazid , rifampicin , streptomycin , pyrazinamide and ethambutol on the generation of reactive oxidants by polymorphonuclear leucocytes was investigated in vitro , using n-formyl-l-methionyl-l-leucyl-phenylalanine ( fmlp ) activated and spontaneous luminol-enhanced chemiluminescence and myeloperoxidase-mediated iodination . | therapeutic_class_of | {
"id": "C0360390",
"name": "antimycobacterial",
"pos": [
19,
36
]
} | {
"id": "C0038425",
"name": "streptomycin",
"pos": [
68,
80
]
} |
the effect of five antimycobacterial drugs isoniazid , rifampicin , streptomycin , pyrazinamide and ethambutol on the generation of reactive oxidants by polymorphonuclear leucocytes was investigated in vitro , using n-formyl-l-methionyl-l-leucyl-phenylalanine ( fmlp ) activated and spontaneous luminol-enhanced chemiluminescence and myeloperoxidase-mediated iodination . | therapeutic_class_of | {
"id": "C0360390",
"name": "antimycobacterial",
"pos": [
19,
36
]
} | {
"id": "C0034239",
"name": "pyrazinamide",
"pos": [
83,
95
]
} |
the effect of five antimycobacterial drugs isoniazid , rifampicin , streptomycin , pyrazinamide and ethambutol on the generation of reactive oxidants by polymorphonuclear leucocytes was investigated in vitro , using n-formyl-l-methionyl-l-leucyl-phenylalanine ( fmlp ) activated and spontaneous luminol-enhanced chemiluminescence and myeloperoxidase-mediated iodination . | therapeutic_class_of | {
"id": "C0360390",
"name": "antimycobacterial",
"pos": [
19,
36
]
} | {
"id": "C0014964",
"name": "ethambutol",
"pos": [
100,
110
]
} |
in an attempt to determine whether the dose of an antiepileptic drug should be increased in epileptic patients who were seizure-free and had subtherapeutic serum levels , 79 patients with idiopathic generalized tonic-clonic seizures treated with monotherapy [ phenytoin ( pht ) or phenobarbital ( pb ) ] and with a subtherapeutic serum level were prospectively studied . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drug",
"pos": [
50,
68
]
} | {
"id": "C0031507",
"name": "phenytoin",
"pos": [
260,
269
]
} |
antifungal prophylaxis with oral nystatin , ketoconazole or amphotericin b , however , has not been consistently effective ; | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
0,
10
]
} | {
"id": "C0022625",
"name": "ketoconazole",
"pos": [
44,
56
]
} |
antifungal prophylaxis with oral nystatin , ketoconazole or amphotericin b , however , has not been consistently effective ; | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
0,
10
]
} | {
"id": "C0002679",
"name": "amphotericin b",
"pos": [
60,
74
]
} |
each patient 's tachycardia was refractory to multiple antiarrhythmic drugs and was being treated with amiodarone at the time of the electrophysiologic study . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drugs",
"pos": [
55,
75
]
} | {
"id": "C0002598",
"name": "amiodarone",
"pos": [
103,
113
]
} |
three antiseptics -- chlorhexidine acetate , silver nitrate and povidone-iodine -- were incorporated into biological dressings ( human skin and amnio-chorion ) and evaluated in vitro against disparate micro-organisms . | therapeutic_class_of | {
"id": "C0003205",
"name": "antiseptics",
"pos": [
6,
17
]
} | {
"id": "C0032857",
"name": "povidone-iodine",
"pos": [
64,
79
]
} |
the in vitro antifungal activity of clotrimazole ( bay b 5097 ) was compared with those of amphotericin b , griseofulvin , nystatin , and pyrrolnitrin . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
13,
23
]
} | {
"id": "C0002679",
"name": "amphotericin b",
"pos": [
91,
105
]
} |
the effect of antidepressant drugs : imipramine , citalopram and mianserin given either in a single dose or twice a day for 14 days in a dose of 10 mg/kg was investigated in mice in tests for the responsiveness of central serotonergic ( l-5 hydroxytryptophan-induced head twitches ) , alpha 2-adrenergic ( donidine hypoactivity ) and cholinergic ( oxotremorine syndrome ) systems . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
14,
28
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
37,
47
]
} |
repeatedly administered antidepressant drugs did not affect the action of oxotremorine , although imipramine ( but not citalopram or mianserin ) antagonized it after a single administration . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant drugs",
"pos": [
24,
44
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
98,
108
]
} |
a liquid chromatographic method for the assay of antiarrhythmic drug amiodarone and its metabolite desethylamiodarone in human plasma or serum has been developed . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drug",
"pos": [
49,
68
]
} | {
"id": "C0002598",
"name": "amiodarone",
"pos": [
107,
117
]
} |
with the use of the modified agar dilution method the present author tested the antifungal activity of griseofulvin and ketoconazole to two spored forms of trichophyton mentagrophytes . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
80,
90
]
} | {
"id": "C0022625",
"name": "ketoconazole",
"pos": [
120,
132
]
} |
in vitro simulation of the level profiles of various antifungals including in particular ketoconazole found in the skin can be simulated in vitro using grasso 's model . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungals",
"pos": [
53,
64
]
} | {
"id": "C0022625",
"name": "ketoconazole",
"pos": [
89,
101
]
} |
taking this fact into account as well as a limited clinical efficacy of conventional treatment protocols it looks rewarding to use conventional antifungal drugs such as ketoconazole at comparatively high doses . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
144,
154
]
} | {
"id": "C0022625",
"name": "ketoconazole",
"pos": [
169,
181
]
} |
a list of compounds , such as amphetamine , taurine , amantadine , allopurinol and , among the new putative antiepileptics , cinromide and gamma-vinyl-gaba , has been tested with some occasionally observed improvement in seizure control . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptics",
"pos": [
108,
122
]
} | {
"id": "C0048044",
"name": "gamma-vinyl-gaba",
"pos": [
139,
155
]
} |
the effect of four antidepressant drugs : imipramine ( imi ) , amitriptyline ( ami ) , citalopram ( cit ) and mianserin ( mia ) , as well as various receptor antagonists : prazosin ( alpha 1 ) , yohimbine ( alpha 2 ) , ritanserin ( 5-ht2 ) , atropine ( ach ) , chlorpyramine ( h1 ) and sch 23,390 ( d-1 ) on grooming potentiated by the selective d-1 receptor agonist skf 38,393 , as well as on spontaneous grooming was studied . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
19,
33
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
42,
52
]
} |
the effect of four antidepressant drugs : imipramine ( imi ) , amitriptyline ( ami ) , citalopram ( cit ) and mianserin ( mia ) , as well as various receptor antagonists : prazosin ( alpha 1 ) , yohimbine ( alpha 2 ) , ritanserin ( 5-ht2 ) , atropine ( ach ) , chlorpyramine ( h1 ) and sch 23,390 ( d-1 ) on grooming potentiated by the selective d-1 receptor agonist skf 38,393 , as well as on spontaneous grooming was studied . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
19,
33
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
63,
76
]
} |
two consecutive nonrandomized studies were conducted in children with prolonged granulocytopenia to evaluate the prophylactic antifungal activity of ketoconazole and the new triazole itraconazole . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
126,
136
]
} | {
"id": "C0022625",
"name": "ketoconazole",
"pos": [
149,
161
]
} |
[ antifungal activity of itraconazole and ketoconazole investigated in vitro , determined with minimal inhibitory concentrations and mycelial cell transformation in candida albicans ] . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
2,
12
]
} | {
"id": "C0022625",
"name": "ketoconazole",
"pos": [
42,
54
]
} |
as a result , the most effectual antibacterials are in order : cefotaxime , cefuroxime , cephalothin , ceftazidime , sulbactam , erythromycin , kanamycin , tetracycline , clindamycin , vancomycin , thiamphenicol , methicillin , penicillin g . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterials",
"pos": [
33,
47
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
63,
73
]
} |
as a result , the most effectual antibacterials are in order : cefotaxime , cefuroxime , cephalothin , ceftazidime , sulbactam , erythromycin , kanamycin , tetracycline , clindamycin , vancomycin , thiamphenicol , methicillin , penicillin g . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterials",
"pos": [
33,
47
]
} | {
"id": "C0007562",
"name": "cefuroxime",
"pos": [
76,
86
]
} |
as a result , the most effectual antibacterials are in order : cefotaxime , cefuroxime , cephalothin , ceftazidime , sulbactam , erythromycin , kanamycin , tetracycline , clindamycin , vancomycin , thiamphenicol , methicillin , penicillin g . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterials",
"pos": [
33,
47
]
} | {
"id": "C0007559",
"name": "ceftazidime",
"pos": [
103,
114
]
} |
as a result , the most effectual antibacterials are in order : cefotaxime , cefuroxime , cephalothin , ceftazidime , sulbactam , erythromycin , kanamycin , tetracycline , clindamycin , vancomycin , thiamphenicol , methicillin , penicillin g . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterials",
"pos": [
33,
47
]
} | {
"id": "C0022487",
"name": "kanamycin",
"pos": [
144,
153
]
} |
as a result , the most effectual antibacterials are in order : cefotaxime , cefuroxime , cephalothin , ceftazidime , sulbactam , erythromycin , kanamycin , tetracycline , clindamycin , vancomycin , thiamphenicol , methicillin , penicillin g . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterials",
"pos": [
33,
47
]
} | {
"id": "C0008947",
"name": "clindamycin",
"pos": [
171,
182
]
} |
as a result , the most effectual antibacterials are in order : cefotaxime , cefuroxime , cephalothin , ceftazidime , sulbactam , erythromycin , kanamycin , tetracycline , clindamycin , vancomycin , thiamphenicol , methicillin , penicillin g . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterials",
"pos": [
33,
47
]
} | {
"id": "C0042313",
"name": "vancomycin",
"pos": [
185,
195
]
} |
as a result , the most effectual antibacterials are in order : cefotaxime , cefuroxime , cephalothin , ceftazidime , sulbactam , erythromycin , kanamycin , tetracycline , clindamycin , vancomycin , thiamphenicol , methicillin , penicillin g . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterials",
"pos": [
33,
47
]
} | {
"id": "C0030827",
"name": "penicillin g",
"pos": [
228,
240
]
} |
antiarrhythmic therapy for the suppression of atrial flutter has conventionally entailed the use of a class ia agent such as quinidine or procainamide . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
0,
14
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
125,
134
]
} |
antiarrhythmic therapy for the suppression of atrial flutter has conventionally entailed the use of a class ia agent such as quinidine or procainamide . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
0,
14
]
} | {
"id": "C0033216",
"name": "procainamide",
"pos": [
138,
150
]
} |
antiviral agents ( final concentration ) included : trifluridine ( tft ) ( 1.0 % ) , ethyldeoxuridine ( edu ) ( 2.0 % ) , and idoxuridine ( idu ) ( 0.1 % ) . | therapeutic_class_of | {
"id": "C0003451",
"name": "antiviral agents",
"pos": [
0,
16
]
} | {
"id": "C0040987",
"name": "trifluridine",
"pos": [
52,
64
]
} |
in 27 of the 30 cases reported here , cure was obtained by prolonged infusions of antifungal drugs , chiefly amphotericin b and/or 5-fluorocytosine . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
82,
92
]
} | {
"id": "C0002679",
"name": "amphotericin b",
"pos": [
109,
123
]
} |
in 27 of the 30 cases reported here , cure was obtained by prolonged infusions of antifungal drugs , chiefly amphotericin b and/or 5-fluorocytosine . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
82,
92
]
} | {
"id": "C0016278",
"name": "5-fluorocytosine",
"pos": [
131,
147
]
} |
thus , against p. haemolytica isolates , ery and sp appeared to represent an effective antimicrobial combination , whereas ery and oxy were only of marginal efficacy as a combination . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial",
"pos": [
87,
100
]
} | {
"id": "C0014806",
"name": "ery",
"pos": [
123,
126
]
} |
thus , against p. haemolytica isolates , ery and sp appeared to represent an effective antimicrobial combination , whereas ery and oxy were only of marginal efficacy as a combination . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial",
"pos": [
87,
100
]
} | {
"id": "C0030092",
"name": "oxy",
"pos": [
131,
134
]
} |
the antimicrobials showing the highest activity were ampicillin , imipenem and ciprofloxacin , followed by cefazolin , cefuroxime , cefotaxime , aztreonam , tigemonam , erythromycin and difloxacin . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobials",
"pos": [
4,
18
]
} | {
"id": "C0008809",
"name": "ciprofloxacin",
"pos": [
79,
92
]
} |
the antimicrobials showing the highest activity were ampicillin , imipenem and ciprofloxacin , followed by cefazolin , cefuroxime , cefotaxime , aztreonam , tigemonam , erythromycin and difloxacin . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobials",
"pos": [
4,
18
]
} | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
169,
181
]
} |
residue determination of two co-administered antibacterial agents -- cephalexin and colistin -- in calf tissues using high-performance liquid chromatography and microbiological methods . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial agents",
"pos": [
45,
65
]
} | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
69,
79
]
} |
residues of two antibacterial agents , cephalexin and colistin , co-administered by intramuscular injection to calves , were quantified in four different tissues ( muscle , fat , liver and kidney ) by column switching hplc and by a microbiological method . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial agents",
"pos": [
16,
36
]
} | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
39,
49
]
} |
there was a remarkably high rate of patients infected by pl . falciparum strains with in vivo resistance to antimalarial agents ( chloroquine and fansidar ) . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial agents",
"pos": [
108,
127
]
} | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
130,
141
]
} |
several antiepileptic drugs change the serum levels of thyroid hormones by different mechanisms , of these diphenylhydantoin being the most known . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drugs",
"pos": [
8,
27
]
} | {
"id": "C0031507",
"name": "diphenylhydantoin",
"pos": [
107,
124
]
} |
high levels of resistance to antimicrobials were noted with penicillin , spectinomycin and cotrimoxazole , while tetracyclines and erythromycin were unvariably effective . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobials",
"pos": [
29,
43
]
} | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
131,
143
]
} |
seven chemical delivery systems ( cds ) based on a dihydropyridine < -- > quaternary pyridinium salt type redox system and analogous to the naturally occurring nadh < -- > nad+ coenzyme system were applied in the case of the antidepressant drug desipramine . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant drug",
"pos": [
225,
244
]
} | {
"id": "C0011685",
"name": "desipramine",
"pos": [
245,
256
]
} |
in vitro study of the antibacterial activity of cefotetan compared with piperacillin and ceftriaxone against bacterial strains isolated from pathological material of hospital patients . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
22,
35
]
} | {
"id": "C0007555",
"name": "cefotetan",
"pos": [
48,
57
]
} |
in vitro study of the antibacterial activity of cefotetan compared with piperacillin and ceftriaxone against bacterial strains isolated from pathological material of hospital patients . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
22,
35
]
} | {
"id": "C0031955",
"name": "piperacillin",
"pos": [
72,
84
]
} |
in vitro study of the antibacterial activity of cefotetan compared with piperacillin and ceftriaxone against bacterial strains isolated from pathological material of hospital patients . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
22,
35
]
} | {
"id": "C0007561",
"name": "ceftriaxone",
"pos": [
89,
100
]
} |
antibacterial activity on staphylococcus aureus of original trimethoprim analogues tested alone or in association with sulfamethoxazole . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
0,
13
]
} | {
"id": "C0041041",
"name": "trimethoprim",
"pos": [
60,
72
]
} |
current status and evolution of antimalarial drug resistance ( with special reference to chloroquine and related blood schizontocides ) . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial drug",
"pos": [
32,
49
]
} | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
89,
100
]
} |
synergistic antibacterial activity of cefotaxime and the penem hre 664 in an improved in vitro model simulating serum and tissue pharmacokinetics . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
12,
25
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
38,
48
]
} |
the sedative antidepressant amitriptyline has proved effective in migraine prophylaxis , chronic tension headache , and psychogenic musculoskeletal and neuralgic facial pain . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
13,
27
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
28,
41
]
} |
in cases of predominantly psychogenic headache , idiopathic trigeminal neuralgia and chronic neck and back pain , the sedative and anxiolytic antidepressant doxepin has been found to be an effective analgesic . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
142,
156
]
} | {
"id": "C0013085",
"name": "doxepin",
"pos": [
157,
164
]
} |
the cardiac antiarrhythmic potency cap50 with 95 % confidence limit was 818 nmole/heart ( 646-985 ) and relative potency 0.22 compared with 0.35 , 0.51 and 1.0 for lidocaine , quinidine and propranolol , respectively . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
12,
26
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
164,
173
]
} |
the cardiac antiarrhythmic potency cap50 with 95 % confidence limit was 818 nmole/heart ( 646-985 ) and relative potency 0.22 compared with 0.35 , 0.51 and 1.0 for lidocaine , quinidine and propranolol , respectively . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
12,
26
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
176,
185
]
} |
antimicrobial therapy with tetracycline hydrochloride plus streptomycin sulfate or sulfamethoxazole and trimethoprim can achieve the sterilization of infected cardiac tissue . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial",
"pos": [
0,
13
]
} | {
"id": "C0546879",
"name": "tetracycline hydrochloride",
"pos": [
27,
53
]
} |
antimicrobial therapy with tetracycline hydrochloride plus streptomycin sulfate or sulfamethoxazole and trimethoprim can achieve the sterilization of infected cardiac tissue . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial",
"pos": [
0,
13
]
} | {
"id": "C0038689",
"name": "sulfamethoxazole",
"pos": [
83,
99
]
} |
when [ 14c ] haloperidol decanoate , a long-acting neuroleptic and an ester of haloperidol and decanoic acid , was incubated in human whole blood and plasma and in rat plasma and homogenates of rat brain , lung , liver , kidney , pancreas and muscle , no hydrolysis of the ester was seen . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
51,
62
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
79,
90
]
} |
clinical , haemodynamic , and antiarrhythmic effects of long term treatment with amiodarone of patients in heart failure . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
30,
44
]
} | {
"id": "C0002598",
"name": "amiodarone",
"pos": [
81,
91
]
} |
in contrast with other antiarrhythmic agents amiodarone is effective in suppressing ventricular arrhythmias in heart failure without causing adverse haemodynamic effects . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agents",
"pos": [
23,
44
]
} | {
"id": "C0002598",
"name": "amiodarone",
"pos": [
45,
55
]
} |
these results suggest that not all antidepressants are antiobsessive and that some property of cmi , such as its potent serotonergic effects , may be of pathophysiological relevance for ocd . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
35,
50
]
} | {
"id": "C0009010",
"name": "cmi",
"pos": [
95,
98
]
} |
the effect of antimalarial drug khingamin preinjection on skin allograft rejection and the level of antibody forming cells ( afc ) in jerne reaction has been investigated . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial",
"pos": [
14,
26
]
} | {
"id": "C0008269",
"name": "khingamin",
"pos": [
32,
41
]
} |
to determine the efficacy of the newer antiarrhythmic drug propafenone and to compare it to disopyramide , sixteen patients -- 11 men and 5 women -- participated in a randomized double-blind crossover placebo-controlled trial using 150 mg quid of propafenone or disopyramide . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
39,
53
]
} | {
"id": "C0033429",
"name": "propafenone",
"pos": [
247,
258
]
} |
to determine the efficacy of the newer antiarrhythmic drug propafenone and to compare it to disopyramide , sixteen patients -- 11 men and 5 women -- participated in a randomized double-blind crossover placebo-controlled trial using 150 mg quid of propafenone or disopyramide . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
39,
53
]
} | {
"id": "C0012702",
"name": "disopyramide",
"pos": [
262,
274
]
} |
the sensitivity of 6 antimicrobials ( chloramphenicol , tetracycline , ampicillin , cephalothin , trimethoprim/sulfamethoxazole and ofloxacin ) was tested on 174 bacteria isolated from three sources : 60 from wounds , 84 from urine and 30 from bronchial excretions . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobials",
"pos": [
21,
35
]
} | {
"id": "C0039644",
"name": "tetracycline",
"pos": [
56,
68
]
} |
the sensitivity of 6 antimicrobials ( chloramphenicol , tetracycline , ampicillin , cephalothin , trimethoprim/sulfamethoxazole and ofloxacin ) was tested on 174 bacteria isolated from three sources : 60 from wounds , 84 from urine and 30 from bronchial excretions . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobials",
"pos": [
21,
35
]
} | {
"id": "C0028902",
"name": "ofloxacin",
"pos": [
132,
141
]
} |
the in vitro antibacterial activity of sulbenicillin was evaluated against multiresistant strains isolated from in-patients and compared with that of carbenicillin and piperacillin . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
13,
26
]
} | {
"id": "C0006976",
"name": "carbenicillin",
"pos": [
150,
163
]
} |
the in vitro antibacterial activity of sulbenicillin was evaluated against multiresistant strains isolated from in-patients and compared with that of carbenicillin and piperacillin . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
13,
26
]
} | {
"id": "C0031955",
"name": "piperacillin",
"pos": [
168,
180
]
} |
a single oral dose of chlorpropamide 250 mg was administered to 8 patients on antiepileptic drugs ( phenytoin , carbamazepine ) and to 8 healthy volunteers . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drugs",
"pos": [
78,
97
]
} | {
"id": "C0031507",
"name": "phenytoin",
"pos": [
100,
109
]
} |
in general the antibacterial spectrum of aztreonam was comparable to that of ceftazidime and superior to that of cefuroxime . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
15,
28
]
} | {
"id": "C0004521",
"name": "aztreonam",
"pos": [
41,
50
]
} |
in general the antibacterial spectrum of aztreonam was comparable to that of ceftazidime and superior to that of cefuroxime . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
15,
28
]
} | {
"id": "C0007559",
"name": "ceftazidime",
"pos": [
77,
88
]
} |
in general the antibacterial spectrum of aztreonam was comparable to that of ceftazidime and superior to that of cefuroxime . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
15,
28
]
} | {
"id": "C0007562",
"name": "cefuroxime",
"pos": [
113,
123
]
} |
a lengthy sample preparation scheme for the high performance liquid chromatographic determination of the antiparasitic agent ivermectin at ppb concentrations in animal plasma is adapted to a laboratory robotic system . | therapeutic_class_of | {
"id": "C0003404",
"name": "antiparasitic agent",
"pos": [
105,
124
]
} | {
"id": "C0022322",
"name": "ivermectin",
"pos": [
125,
135
]
} |
young adults treated with a high potency neuroleptic such as haloperidol are at high risk of developing dystonic reactions . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
41,
52
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
61,
72
]
} |
plants as sources of antimalarial drugs , part 4 : activity of brucea javanica fruits against chloroquine-resistant plasmodium falciparum in vitro and against plasmodium berghei in vivo . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial drugs",
"pos": [
21,
39
]
} | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
94,
105
]
} |
in contrast , other slow acting antirheumatic drugs , sulfasalazine , chloroquine and hydroxychloroquine , show partial inhibition of colony development but at concentrations of the order of 10 ( -5 ) m . | therapeutic_class_of | {
"id": "C0003191",
"name": "antirheumatic drugs",
"pos": [
32,
51
]
} | {
"id": "C0020336",
"name": "hydroxychloroquine",
"pos": [
86,
104
]
} |
the efficacy rate of the combination therapy with other antifungal agents was 60 % in comparison with 57 % of mcz alone . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal agents",
"pos": [
56,
73
]
} | {
"id": "C0025942",
"name": "mcz",
"pos": [
110,
113
]
} |
the in vitro and in vivo antibacterial activities of a new aminoglycoside antibiotic , arbekacin ( hbk ) , against methicillin-cephem-resistant staphylococcus aureus ( mrsa ) were compared with those of gentamicin ( gm ) , netilmicin ( ntl ) and amikacin ( amk ) . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
25,
38
]
} | {
"id": "C0027780",
"name": "netilmicin",
"pos": [
223,
233
]
} |
the in vitro and in vivo antibacterial activities of a new aminoglycoside antibiotic , arbekacin ( hbk ) , against methicillin-cephem-resistant staphylococcus aureus ( mrsa ) were compared with those of gentamicin ( gm ) , netilmicin ( ntl ) and amikacin ( amk ) . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
25,
38
]
} | {
"id": "C0002499",
"name": "amikacin",
"pos": [
246,
254
]
} |
antibacterial activity of czon on s. aureus was similar to that of cefazolin , inferior to that of cloxacillin , and superior to those of benzylpenicillin and cefotaxime . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
0,
13
]
} | {
"id": "C0007546",
"name": "cefazolin",
"pos": [
67,
76
]
} |
antibacterial activity of czon on s. aureus was similar to that of cefazolin , inferior to that of cloxacillin , and superior to those of benzylpenicillin and cefotaxime . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
0,
13
]
} | {
"id": "C0030827",
"name": "benzylpenicillin",
"pos": [
138,
154
]
} |
antibacterial activity of czon on s. aureus was similar to that of cefazolin , inferior to that of cloxacillin , and superior to those of benzylpenicillin and cefotaxime . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
0,
13
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
159,
169
]
} |
antibacterial activities of czon against clinically isolated strains of staphylococcus aureus , s. epidermidis , streptococcus pneumoniae , s. pyogenes , escherichia coli , klebsiella pneumoniae , haemophilus parainfluenzae and h. influenzae were compared with those of cefmenoxime ( cmx ) , latamoxef ( lmox ) , cefoperazone ( cpz ) , cefmetazole ( cmz ) , cefotiam ( ctm ) and cefazolin ( cez ) . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
0,
13
]
} | {
"id": "C0007552",
"name": "cefoperazone",
"pos": [
313,
325
]
} |
antibacterial activities of czon against clinically isolated strains of staphylococcus aureus , s. epidermidis , streptococcus pneumoniae , s. pyogenes , escherichia coli , klebsiella pneumoniae , haemophilus parainfluenzae and h. influenzae were compared with those of cefmenoxime ( cmx ) , latamoxef ( lmox ) , cefoperazone ( cpz ) , cefmetazole ( cmz ) , cefotiam ( ctm ) and cefazolin ( cez ) . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
0,
13
]
} | {
"id": "C0007546",
"name": "cefazolin",
"pos": [
379,
388
]
} |
the mode of antiarrhythmic actions of the newly developed antiarrhythmic drugs , tocainide , mexiletine and sun1165 , which bear the n-2,6-dimethylbenzene ring as a common structural unit , were examined by comparing the use-dependent blocking actions on the maximum rate of rise of action potentials ( vmax ) in guinea pig ventricular muscle . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drugs",
"pos": [
58,
78
]
} | {
"id": "C0025887",
"name": "mexiletine",
"pos": [
93,
103
]
} |
however , unlike the bcf1 mice , young bwf1 mice were unable to produce a good anti-phosphorylcholine plaque-forming cell response after the killing of trichinella larvae by the anthelminthic mebendazole . | therapeutic_class_of | {
"id": "C0003158",
"name": "anthelminthic",
"pos": [
178,
191
]
} | {
"id": "C0025023",
"name": "mebendazole",
"pos": [
192,
203
]
} |
with the aim of evaluating the possible functional modifications of both d1 and d2 dopamine receptor subpopulations after repeated administration of neuroleptics , the ability of selective d1 and d2 dopamine agonists to stimulate or inhibit , respectively , the activity of adenylate cyclase in the striatum and nucleus accumbens of rats treated with either saline or haloperidol for 21 days , was studied . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
149,
161
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
368,
379
]
} |
the central mechanism responsible for the potentiation by antidepressant drugs of analgesia induced by morphine , was explored by measuring the levels of various neuropeptides ( met-enkephalin , leu-enkephalin , dynorphin , substance p and cholecystokinin-like materials ) and the density of delta and mu opioid binding sites in the spinal cord of rats treated for 14 days with amoxapine ( 10 mg/kg i.p. , daily ) or amitriptyline ( 10 mg/kg i.p. , daily ) . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant drugs",
"pos": [
58,
78
]
} | {
"id": "C0002644",
"name": "amoxapine",
"pos": [
378,
387
]
} |
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