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serum neuroleptic levels were measured by radioreceptor assay in patients treated with the antidepressant amoxapine . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
91,
105
]
} | {
"id": "C0002644",
"name": "amoxapine",
"pos": [
106,
115
]
} |
the increase in brain antidepressant binding sites is discussed in relationship to other indices of brain serotonergic function in aging and to the relationship of [ 3h ] imipramine binding and depression . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
22,
36
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
171,
181
]
} |
all major antidepressants ( desipramine , amitryptyline or maprotiline ) , several newer compounds with reported antidepressant activity ( viloxazine , zimelidine , fluoxetine , citalopram , progabide , fengabine , sodium valproate , mianserin , trazodone or nomifensine ) as well as pargyline and repeated electroshocks , up-regulated gaba b binding in the rat frontal cortex but not hippocampus . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
10,
24
]
} | {
"id": "C0037567",
"name": "sodium",
"pos": [
215,
221
]
} |
its in vitro antibacterial activity was less than those of cefoxitin against peptostreptococcus and veillonella , but was significantly high against bacteroides fragilis , one of the most clinically important anaerobe . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
13,
26
]
} | {
"id": "C0007557",
"name": "cefoxitin",
"pos": [
59,
68
]
} |
chronic ( 14-day ) treatment with reserpine resulted in a significant increase in beta-adrenergic receptor binding in the cerebral cortex and the hippocampus , which was partially prevented by chronic treatment with either the antidepressant imipramine , the gaba-a agonist thip or , the gaba-b agonist baclofen . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
227,
241
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
242,
252
]
} |
the two neuroleptics were similar in acute anti-apomorphine potency ( id50 = 0.12 and 0.18 mg/kg for haloperidol and droperidol , respectively ) . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
8,
20
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
101,
112
]
} |
the utility of the antiarrhythmic drug procainamide ( pa ) is limited by the required dosage schedule ( every three to four hours ) . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drug",
"pos": [
19,
38
]
} | {
"id": "C0033216",
"name": "procainamide",
"pos": [
39,
51
]
} |
to study the possible mechanisms of the formation of secondary therapeutic resistance , the author carried out a chronic experiment on animals which were administered different doses of a neuroleptic ( haloperidol ) for 20 days . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
188,
199
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
202,
213
]
} |
the antiarrhythmic efficacy and safety of oral tocainide hydrochloride and quinidine sulfate were compared in a double-blind , 3-center , parallel trial involving 133 patients with benign and potentially lethal ventricular arrhythmias . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
4,
18
]
} | {
"id": "C0034415",
"name": "quinidine sulfate",
"pos": [
75,
92
]
} |
the role that the new antiarrhythmic agents , such as verapamil and amiodarone , might play in the therapeutic strategy of tachycardia-induced fetal heart failure remains to be determined . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agents",
"pos": [
22,
43
]
} | {
"id": "C0002598",
"name": "amiodarone",
"pos": [
68,
78
]
} |
the purpose of this study was to examine the mechanisms involved in the uptake of the urinary antibacterial drug trimethoprim by incubated slices of rat renal cortex . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial drug",
"pos": [
94,
112
]
} | {
"id": "C0041041",
"name": "trimethoprim",
"pos": [
113,
125
]
} |
[ determination of the concentration of a new antiarrhythmic , flecainide , in plasma using high pressure liquid chromatography ( hplc ) : sample preparation with extraction columns ] . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
46,
60
]
} | {
"id": "C0016229",
"name": "flecainide",
"pos": [
63,
73
]
} |
eighteen patients with huntington 's chorea were examined before and after neuroleptic treatment ( haloperidol , pimozide , tiapride ) to study the effect of such treatment on hyperkinesia and motor performance . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
75,
86
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
99,
110
]
} |
eighteen patients with huntington 's chorea were examined before and after neuroleptic treatment ( haloperidol , pimozide , tiapride ) to study the effect of such treatment on hyperkinesia and motor performance . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
75,
86
]
} | {
"id": "C0031935",
"name": "pimozide",
"pos": [
113,
121
]
} |
1- [ 2,5-dichloro-6- [ 1- ( 1h-imidazol-1-yl ) -ethenyl ] phenoxy ] -3- [ ( 1-methylethyl ) amino ] -2-propanol hydrochloride ( 48 ) ( 711389-s ) was selected as a candidate for clinical evaluation in man , since its antiarrhythmic effects were superior to those of quinidine , disopyramide , or propranolol . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
217,
231
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
266,
275
]
} |
1- [ 2,5-dichloro-6- [ 1- ( 1h-imidazol-1-yl ) -ethenyl ] phenoxy ] -3- [ ( 1-methylethyl ) amino ] -2-propanol hydrochloride ( 48 ) ( 711389-s ) was selected as a candidate for clinical evaluation in man , since its antiarrhythmic effects were superior to those of quinidine , disopyramide , or propranolol . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
217,
231
]
} | {
"id": "C0012702",
"name": "disopyramide",
"pos": [
278,
290
]
} |
[ antibiotic therapy : use and clinical evaluation of a new antibacterial drug , ceftazidime ( rg 159 ) administered parenterally in children ] . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
60,
73
]
} | {
"id": "C0007559",
"name": "ceftazidime",
"pos": [
81,
92
]
} |
in contrast , the agonist-induced asymmetric and circling behaviours of electrolesioned rats were some 9-44 times more sensitive than those of 6-ohda lesioned rats to antagonism by the neuroleptic agents haloperidol , alpha-flupenthixol and oxiperomide , although tiapride antagonism was very similar in both the electrolesioned and 6-ohda-lesioned rats . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic agents",
"pos": [
185,
203
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
204,
215
]
} |
the effects of a new antiarrhythmic compound , sun 1165 ( which resembles lidocaine in chemical structure ) on sodium currents ( ina ) of enzymatically isolated , single rat ventricle cells were studied under current or voltage clamp conditions . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
21,
35
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
74,
83
]
} |
the presently reported findings : that spaced electroconvulsive treatment increases the density of alpha-1 adrenoceptor in the spinal cord as well as in the cerebral cortex of the rat , that treatment with various classes of antidepressant drugs , including antidepressant neuroleptics , affects in a similar manner alpha-adrenoceptors , elevating within 2 weeks the density of alpha-1 , and depressing the density of alpha-2 subpopulation , and that prolonged imipramine treatment in investigated strains of rats does not depress the beta adrenoceptor density within 3 weeks , but only after 6-week-treatment such an effect is observed , are discussed together with our earlier results . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
225,
239
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
461,
471
]
} |
neuroleptics such as the thioxanthene , cis ( z ) -flupentixol , the phenothiazine , fluphenazine , the butyrophenone , haloperidol and the benzamide clebopride are equipotent behaviourally as well as clinically . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
0,
12
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
120,
131
]
} |
prolonged , 21-days treatment with some antidepressant ( imipramine , nomifensin and mianserin ) markedly reduced the response of the type i inhibitor activity to isoprenaline . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
40,
54
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
57,
67
]
} |
sigma opiates and certain antipsychotic drugs mutually inhibit ( + ) - [ 3h ] skf 10,047 and [ 3h ] haloperidol binding in guinea pig brain membranes . | therapeutic_class_of | {
"id": "C0040615",
"name": "antipsychotic drugs",
"pos": [
26,
45
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
100,
111
]
} |
some antipsychotic drugs inhibited ( + ) - [ 3h ] skf 10,047 binding with high to moderate affinities in the following order of potency : haloperidol greater than perphenazine greater than fluphenazine greater than acetophenazine greater than trifluoperazine greater than molindone greater than or equal to pimozide greater than or equal to thioridazine greater than or equal to chlorpromazine greater than or equal to triflupromazine . | therapeutic_class_of | {
"id": "C0040615",
"name": "antipsychotic drugs",
"pos": [
5,
24
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
138,
149
]
} |
some antipsychotic drugs inhibited ( + ) - [ 3h ] skf 10,047 binding with high to moderate affinities in the following order of potency : haloperidol greater than perphenazine greater than fluphenazine greater than acetophenazine greater than trifluoperazine greater than molindone greater than or equal to pimozide greater than or equal to thioridazine greater than or equal to chlorpromazine greater than or equal to triflupromazine . | therapeutic_class_of | {
"id": "C0040615",
"name": "antipsychotic drugs",
"pos": [
5,
24
]
} | {
"id": "C0026388",
"name": "molindone",
"pos": [
272,
281
]
} |
some antipsychotic drugs inhibited ( + ) - [ 3h ] skf 10,047 binding with high to moderate affinities in the following order of potency : haloperidol greater than perphenazine greater than fluphenazine greater than acetophenazine greater than trifluoperazine greater than molindone greater than or equal to pimozide greater than or equal to thioridazine greater than or equal to chlorpromazine greater than or equal to triflupromazine . | therapeutic_class_of | {
"id": "C0040615",
"name": "antipsychotic drugs",
"pos": [
5,
24
]
} | {
"id": "C0031935",
"name": "pimozide",
"pos": [
307,
315
]
} |
the data appear to be consistent with the hypothesis that the antidepressant action of desipramine is mediated by alpha 2-autoreceptor desensitization . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
62,
76
]
} | {
"id": "C0011685",
"name": "desipramine",
"pos": [
87,
98
]
} |
to determine the optimal schemes of rational antibacterial therapy of pyelonephritis gravidarum with ampicillin and cephuroxim , assays of the patient urine and studies on the pharmacokinetics of the drugs were performed . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
45,
58
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
101,
111
]
} |
new micromethod to study the effect of antimicrobial agents on toxoplasma gondii : comparison of sulfadoxine and sulfadiazine individually and in combination with pyrimethamine and study of clindamycin , metronidazole , and cyclosporin a . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial agents",
"pos": [
39,
59
]
} | {
"id": "C0025872",
"name": "metronidazole",
"pos": [
204,
217
]
} |
masked controlled rabbit studies were done to determine the toxic effects on corneal wound healing of the antiviral ointments 0.5 % idoxuridine , 3 % ara a , and 3 % acyclovir , and the antiviral drops 0.1 % idoxuridine , 3 % ara amp , and 1 % trifluridine . | therapeutic_class_of | {
"id": "C0003451",
"name": "antiviral",
"pos": [
106,
115
]
} | {
"id": "C0040987",
"name": "trifluridine",
"pos": [
244,
256
]
} |
these antimicrobials were the bactericidal aminoglycoside antibiotics , streptomycin , gentamicin and kanamycin , the bacteriostatic protein synthesis inhibitors , chloramphenicol and chlortetracycline and the antifungals , 5-fluorocytosine , nystatin and amphotericin b . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungals",
"pos": [
210,
221
]
} | {
"id": "C0016278",
"name": "5-fluorocytosine",
"pos": [
224,
240
]
} |
these antimicrobials were the bactericidal aminoglycoside antibiotics , streptomycin , gentamicin and kanamycin , the bacteriostatic protein synthesis inhibitors , chloramphenicol and chlortetracycline and the antifungals , 5-fluorocytosine , nystatin and amphotericin b . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungals",
"pos": [
210,
221
]
} | {
"id": "C0002679",
"name": "amphotericin b",
"pos": [
256,
270
]
} |
this compares with a value of 1.35 x 10 ( -2 ) micrograms ml-1 for the standard antimalarial , chloroquine . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial",
"pos": [
80,
92
]
} | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
95,
106
]
} |
these data lead to the conclusion that cibenzoline has the characteristics of class i and some class iv anti-arrhythmic action , but cibenzoline is not another quinidine because it would not appear to influence outward potassium current . | therapeutic_class_of | {
"id": "C0003195",
"name": "anti-arrhythmic",
"pos": [
104,
119
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
160,
169
]
} |
zetidoline ( ztd ) , a compound chemically unrelated to any available antipsychotic , with selective dopamine receptor-blocking properties , was compared with haloperidol ( hlp ) in a double-blind study on 56 in-patients who had either first episodes or acute relapses of schizophrenia . | therapeutic_class_of | {
"id": "C0040615",
"name": "antipsychotic",
"pos": [
70,
83
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
159,
170
]
} |
there was significant improvement in all treatment groups except those treated with antiseptic lavage using pvp-i and noxythiolin . | therapeutic_class_of | {
"id": "C0003205",
"name": "antiseptic",
"pos": [
84,
94
]
} | {
"id": "C0032857",
"name": "pvp-i",
"pos": [
108,
113
]
} |
a prospective controlled trial on the use of 1 month 's antimicrobial therapy in patients with relapse of crohn 's disease revealed that metronidazole was associated with a 57 % response rate , compared with a response of only 17 % in patients receiving no metronidazole . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial",
"pos": [
56,
69
]
} | {
"id": "C0025872",
"name": "metronidazole",
"pos": [
257,
270
]
} |
twenty-one patients whose severe ventricular arrhythmias were not controlled by other currently used antiarrhythmic agents or who were intolerant of those drugs were treated with a new antiarrhythmic agent , propafenone . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agent",
"pos": [
101,
121
]
} | {
"id": "C0033429",
"name": "propafenone",
"pos": [
208,
219
]
} |
the efficacy of a new antiarrhythmic agent , lorcainide , was compared with that of quinidine gluconate in a fixed-dose , randomized , crossover trial . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agent",
"pos": [
22,
42
]
} | {
"id": "C0072869",
"name": "quinidine gluconate",
"pos": [
84,
103
]
} |
the antiarrhythmic efficacy of mexiletine in acute myocardial infarction ( ami ) was studied in 99 patients randomized to mexiletine or placebo treatment . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
4,
18
]
} | {
"id": "C0025887",
"name": "mexiletine",
"pos": [
122,
132
]
} |
the antibacterial potency of 250 mg/kg of amikacin is comparable to that of 100 mg/kg of hydroxygentamicin . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0002499",
"name": "amikacin",
"pos": [
42,
50
]
} |
it was concluded that fluoxetine provides effective antidepressant activity with fewer and less troublesome side effects than imipramine . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
52,
66
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
126,
136
]
} |
an increased prescription of dmard was found at a national level ( sweden ) , starting with chloroquine , followed by penicillamine and finally by gold . | therapeutic_class_of | {
"id": "C0003191",
"name": "dmard",
"pos": [
29,
34
]
} | {
"id": "C0030817",
"name": "penicillamine",
"pos": [
118,
131
]
} |
since this metabolite is equipotent to nt in inhibiting neuronal noradrenaline uptake , it is suggested that it might be of clinical value as an antidepressant by virtue of having less anticholinergic side-effects than nt itself . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
145,
159
]
} | {
"id": "C0028420",
"name": "nt",
"pos": [
219,
221
]
} |
the discriminative stimulus effects of cocaine ( 3.0 mg/kg ) were attenuated in a dose-related manner by the neuroleptic haloperidol ( dose range tested : 0.1-1.0 mg/kg ) . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
109,
120
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
121,
132
]
} |
a multicenter clinical trial of 274 patients compared the efficacy and safety of a new vaginal antifungal compound , butoconazole nitrate cream 2 % ( butoconazole ) , to clotrimazole vaginal tablets 200 mg/day ( clotrimazole ) . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
95,
105
]
} | {
"id": "C0107509",
"name": "butoconazole nitrate",
"pos": [
117,
137
]
} |
these results suggest that vft in anaesthetized cats is markedly increased by beta-adrenoceptor blockade and only marginally increased by the direct class iii antiarrhythmic action of d-sotalol . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
159,
173
]
} | {
"id": "C0037707",
"name": "sotalol",
"pos": [
186,
193
]
} |
effects of three class i antiarrhythmic drugs ( quinidine , lidocaine , and prajmaline ) on transmembrane resting ( rmp ) and action potentials ( ap ) of isolated rabbit atrial and ventricular myocardium were studied at different stimulation rates . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
25,
39
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
48,
57
]
} |
effects of three class i antiarrhythmic drugs ( quinidine , lidocaine , and prajmaline ) on transmembrane resting ( rmp ) and action potentials ( ap ) of isolated rabbit atrial and ventricular myocardium were studied at different stimulation rates . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
25,
39
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
60,
69
]
} |
the mean ( +/- sd ) antiarrhythmic unbound serum concentration range of s ( + ) -disopyramide was 0.55 +/- 0.31-0.90 +/- 0.81 mg/l . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
20,
34
]
} | {
"id": "C0012702",
"name": "disopyramide",
"pos": [
81,
93
]
} |
the data suggest that the antiarrhythmic activity associated with racemic disopyramide resides in the s ( + ) enantiomer . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
26,
40
]
} | {
"id": "C0012702",
"name": "disopyramide",
"pos": [
74,
86
]
} |
continuous-wave doppler measurements of ascending aortic blood flow velocity were obtained in 16 patients while not receiving antiarrhythmic drugs on 2 consecutive days to assess day-to-day variability , as well as while receiving maximally tolerated oral doses of mexiletine ( 11 patients ) and propafenone ( 9 patients ) . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drugs",
"pos": [
126,
146
]
} | {
"id": "C0033429",
"name": "propafenone",
"pos": [
296,
307
]
} |
in conclusion , although the three type i antiarrhythmic agents tested may all adversely affect left ventricular function in patients with heart failure , encainide and tocainide are more likely than procainamide to cause hemodynamic and clinical deterioration . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agents",
"pos": [
42,
63
]
} | {
"id": "C0033216",
"name": "procainamide",
"pos": [
200,
212
]
} |
a case of acute urinary retention , presumably secondary to the use of the antiarrhythmic drug flecainide , is presented . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drug",
"pos": [
75,
94
]
} | {
"id": "C0016229",
"name": "flecainide",
"pos": [
95,
105
]
} |
to shorten the latency-to-response time for antidepressant treatment , three patients diagnosed with major depression were treated simultaneously with lithium and nortriptyline . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
44,
58
]
} | {
"id": "C0028420",
"name": "nortriptyline",
"pos": [
163,
176
]
} |
class iii antiarrhythmic action linked with positive inotropy : acute electrophysiological and inotropic effects of amiodarone in vitro . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
10,
24
]
} | {
"id": "C0002598",
"name": "amiodarone",
"pos": [
116,
126
]
} |
the antidepressants , imipramine-like ( imipramine , chlorimipramine , desipramine , metapramine and amitriptyline ) and non-imipraminic ( minaprine , maprotiline , viloxazine , mianserin , fluvoxamine and indalpine ) , and the 3 noted above , had potentially convulsive effects . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
4,
19
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
58,
68
]
} |
the antidepressants , imipramine-like ( imipramine , chlorimipramine , desipramine , metapramine and amitriptyline ) and non-imipraminic ( minaprine , maprotiline , viloxazine , mianserin , fluvoxamine and indalpine ) , and the 3 noted above , had potentially convulsive effects . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
4,
19
]
} | {
"id": "C0009010",
"name": "chlorimipramine",
"pos": [
53,
68
]
} |
the antidepressants , imipramine-like ( imipramine , chlorimipramine , desipramine , metapramine and amitriptyline ) and non-imipraminic ( minaprine , maprotiline , viloxazine , mianserin , fluvoxamine and indalpine ) , and the 3 noted above , had potentially convulsive effects . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
4,
19
]
} | {
"id": "C0011685",
"name": "desipramine",
"pos": [
71,
82
]
} |
the antidepressants , imipramine-like ( imipramine , chlorimipramine , desipramine , metapramine and amitriptyline ) and non-imipraminic ( minaprine , maprotiline , viloxazine , mianserin , fluvoxamine and indalpine ) , and the 3 noted above , had potentially convulsive effects . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
4,
19
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
101,
114
]
} |
in the latter two models , da depletion in the prefrontal cortex did not modify the antidepressant effects of desipramine ( 32 mg/kg and 24 mg/kg/day , respectively ) . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
84,
98
]
} | {
"id": "C0011685",
"name": "desipramine",
"pos": [
110,
121
]
} |
the antifungal agent amphotericin b ( amb ) holds interesting immunomodulating properties and its n-thiopropionyl derivative ( ambsh ) is a potent polyclonal b-cell activator . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal agent",
"pos": [
4,
20
]
} | {
"id": "C0002679",
"name": "amphotericin b",
"pos": [
21,
35
]
} |
further , this antimicrobial efficacy was greatly increased in a silicone gel sheet that contained 0.02 % of oflx and an additional 10 % of silicone oil . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial",
"pos": [
15,
28
]
} | {
"id": "C0028902",
"name": "oflx",
"pos": [
109,
113
]
} |
other antidepressant agents -- notably amitriptyline -- are known to ameliorate postherpetic neuralgia , but those agents are often toxic . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant agents",
"pos": [
6,
27
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
39,
52
]
} |
however , in addition to its role as an antidepressant , attention is being focused on the use of clomipramine in 2 other areas of psychiatry : obsessive compulsive disorder and panic disorder . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
40,
54
]
} | {
"id": "C0009010",
"name": "clomipramine",
"pos": [
98,
110
]
} |
the actions of the antiepileptic drugs phenytoin , carbamazepine and phenobarbitone , and the local anaesthetic drugs lignocaine and procaine on sodium-dependent and calcium-dependent compound action potentials ( na- and ca-spikes ) have been compared in rat preganglionic cervical sympathetic nerves , using extracellular recording techniques . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drugs",
"pos": [
19,
38
]
} | {
"id": "C0031507",
"name": "phenytoin",
"pos": [
39,
48
]
} |
the possibility that neuroleptic-induced dopamine d2 receptor supersensitivity involves an alteration in brain iron content was investigated in nutritionally iron-deficient and control rats chronically treated with haloperidol ( 5 mg/kg daily for 14 or 21 days ) . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
21,
32
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
215,
226
]
} |
the neuroleptic drug haloperidol , a d2 receptor antagonist , was found to produce a rapid and transient induction of c-fos mrna expression as compared with the expression in animals treated with saline . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
4,
15
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
21,
32
]
} |
in conclusion , the classical antipsychotic drug , haloperidol , clearly decreases dopamine turnover in nigrostriatal and mesolimbic dopaminergic systems . | therapeutic_class_of | {
"id": "C0040615",
"name": "antipsychotic drug",
"pos": [
30,
48
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
51,
62
]
} |
the effects of post-trial administration of amineptine , a dopaminergic antidepressant drug , were compared with those of memory-facilitating ( strychnine , piracetam ) or impairing drugs ( phenobarbital , imipramine ) on an experimental model of memory . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant drug",
"pos": [
72,
91
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
206,
216
]
} |
increases in rat striatal preproenkephalin mrna levels following chronic treatment with the depot neuroleptic , haloperidol decanoate . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
98,
109
]
} | {
"id": "C0062103",
"name": "haloperidol decanoate",
"pos": [
112,
133
]
} |
therefore , as a result of the increasing utilization of depot neuroleptics therapeutically , we examined the effects of haloperidol decanoate on striatal preproenkephalin mrna levels . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
63,
75
]
} | {
"id": "C0062103",
"name": "haloperidol decanoate",
"pos": [
121,
142
]
} |
the acute administration of cyclic antidepressant drugs ( 2.5 mg/kg , i.v . ) resulted in different mydriatic effects ( amitriptyline greater than protriptyline approximately imipramine greater than clomipramine greater than nortriptyline greater than desipramine approximately maprotiline ) which were attenuated ( 17-55 % ) by idazoxan ( 1 mg/kg , i.v. , 5 min ) and reserpine ( 5 mg/kg , s.c. , 18 h ) indicating that , besides the well-known anticholinergic properties of some of these drugs , their mydriatic effects are due in part to activation of alpha 2-adrenoceptors ( through endogenous noradrenaline ) . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
35,
49
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
120,
133
]
} |
the acute administration of cyclic antidepressant drugs ( 2.5 mg/kg , i.v . ) resulted in different mydriatic effects ( amitriptyline greater than protriptyline approximately imipramine greater than clomipramine greater than nortriptyline greater than desipramine approximately maprotiline ) which were attenuated ( 17-55 % ) by idazoxan ( 1 mg/kg , i.v. , 5 min ) and reserpine ( 5 mg/kg , s.c. , 18 h ) indicating that , besides the well-known anticholinergic properties of some of these drugs , their mydriatic effects are due in part to activation of alpha 2-adrenoceptors ( through endogenous noradrenaline ) . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
35,
49
]
} | {
"id": "C0033743",
"name": "protriptyline",
"pos": [
147,
160
]
} |
the acute administration of cyclic antidepressant drugs ( 2.5 mg/kg , i.v . ) resulted in different mydriatic effects ( amitriptyline greater than protriptyline approximately imipramine greater than clomipramine greater than nortriptyline greater than desipramine approximately maprotiline ) which were attenuated ( 17-55 % ) by idazoxan ( 1 mg/kg , i.v. , 5 min ) and reserpine ( 5 mg/kg , s.c. , 18 h ) indicating that , besides the well-known anticholinergic properties of some of these drugs , their mydriatic effects are due in part to activation of alpha 2-adrenoceptors ( through endogenous noradrenaline ) . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
35,
49
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
175,
185
]
} |
the acute administration of cyclic antidepressant drugs ( 2.5 mg/kg , i.v . ) resulted in different mydriatic effects ( amitriptyline greater than protriptyline approximately imipramine greater than clomipramine greater than nortriptyline greater than desipramine approximately maprotiline ) which were attenuated ( 17-55 % ) by idazoxan ( 1 mg/kg , i.v. , 5 min ) and reserpine ( 5 mg/kg , s.c. , 18 h ) indicating that , besides the well-known anticholinergic properties of some of these drugs , their mydriatic effects are due in part to activation of alpha 2-adrenoceptors ( through endogenous noradrenaline ) . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
35,
49
]
} | {
"id": "C0009010",
"name": "clomipramine",
"pos": [
199,
211
]
} |
the acute administration of cyclic antidepressant drugs ( 2.5 mg/kg , i.v . ) resulted in different mydriatic effects ( amitriptyline greater than protriptyline approximately imipramine greater than clomipramine greater than nortriptyline greater than desipramine approximately maprotiline ) which were attenuated ( 17-55 % ) by idazoxan ( 1 mg/kg , i.v. , 5 min ) and reserpine ( 5 mg/kg , s.c. , 18 h ) indicating that , besides the well-known anticholinergic properties of some of these drugs , their mydriatic effects are due in part to activation of alpha 2-adrenoceptors ( through endogenous noradrenaline ) . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
35,
49
]
} | {
"id": "C0028420",
"name": "nortriptyline",
"pos": [
225,
238
]
} |
the acute administration of cyclic antidepressant drugs ( 2.5 mg/kg , i.v . ) resulted in different mydriatic effects ( amitriptyline greater than protriptyline approximately imipramine greater than clomipramine greater than nortriptyline greater than desipramine approximately maprotiline ) which were attenuated ( 17-55 % ) by idazoxan ( 1 mg/kg , i.v. , 5 min ) and reserpine ( 5 mg/kg , s.c. , 18 h ) indicating that , besides the well-known anticholinergic properties of some of these drugs , their mydriatic effects are due in part to activation of alpha 2-adrenoceptors ( through endogenous noradrenaline ) . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
35,
49
]
} | {
"id": "C0011685",
"name": "desipramine",
"pos": [
252,
263
]
} |
resistance of p. falciparum to other anti-malaria drugs , e.g. , chloroquine and pyrimethamine , did not affect susceptibility of its asexual and sexual stages to qinghaosu . | therapeutic_class_of | {
"id": "C0003374",
"name": "anti-malaria",
"pos": [
37,
49
]
} | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
65,
76
]
} |
porcine taenia solium cysticercosis , recognized as a model of the human disease , was used to analyze the effect of the anthelminthic drug praziquantel on hosts and parasites . | therapeutic_class_of | {
"id": "C0003158",
"name": "anthelminthic",
"pos": [
121,
134
]
} | {
"id": "C0032911",
"name": "praziquantel",
"pos": [
140,
152
]
} |
the potency of the classical neuroleptic haloperidol ( 0.03-0.25 mg/kg ip ) to antagonize apomorphine-induced hypermotility was reduced in 6-ohda-pretreated rats . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
29,
40
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
41,
52
]
} |
perphenazine was discontinued after the fourth episode of priapism and antipsychotic treatment with thiothixene was subsequently initiated . | therapeutic_class_of | {
"id": "C0040615",
"name": "antipsychotic",
"pos": [
71,
84
]
} | {
"id": "C0039955",
"name": "thiothixene",
"pos": [
100,
111
]
} |
differences in epms rates between the two most frequently used neuroleptics , haloperidol , a high-potency butyrophenone , and perazine , a medium-potency phenothiazine , were distinct . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
63,
75
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
78,
89
]
} |
the antiarrhythmic agent lidocaine ( 20 microm ) inhibits current flow through the channel in a voltage-dependent fashion . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
4,
18
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
25,
34
]
} |
the antimicrobial agent used was erythromycin in one case , amoxicillin in one case , and a third generation cephalosporin in two cases . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial agent",
"pos": [
4,
23
]
} | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
33,
45
]
} |
effect of the antiepileptic drug sodium valproate on glutamine and glutamate metabolism in isolated human kidney tubules . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic",
"pos": [
14,
27
]
} | {
"id": "C0037567",
"name": "sodium valproate",
"pos": [
33,
49
]
} |
three such compounds , an antihistamine ( tripelennamine ) , a neuroleptic ( haloperidol ) , and an anxiolytic ( oxazepam ) were examined for their behavioral and neuroendocrine effects . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
63,
74
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
77,
88
]
} |
[ therapeutic experiences in the treatment of hyperkineses with the neuroleptic pimozide ( antalon , orap ) in the frame of huntington chorea ] . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
68,
79
]
} | {
"id": "C0031935",
"name": "pimozide",
"pos": [
80,
88
]
} |
because cimetidine can inhibit the cytochrome p450 mixed-function oxidase system , we believe it could decrease the production of the hepatotoxic acetaminophen metabolite ( s ) providing an effective antidote to be used in conjunction with acetylcysteine . | therapeutic_class_of | {
"id": "C0003295",
"name": "antidote",
"pos": [
200,
208
]
} | {
"id": "C0001047",
"name": "acetylcysteine",
"pos": [
240,
254
]
} |
[ comparative study of the effect of the antimalarials dabequin and chloroquine on retinal ultrastructure in the rat ] . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarials",
"pos": [
41,
54
]
} | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
68,
79
]
} |
[ antiarrhythmic efficacy of mexiletine , propafenone and flecainide in ventricular premature beats . a comparative study in patients after myocardial infarction ( author 's transl ) ] . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
2,
16
]
} | {
"id": "C0025887",
"name": "mexiletine",
"pos": [
29,
39
]
} |
[ antiarrhythmic efficacy of mexiletine , propafenone and flecainide in ventricular premature beats . a comparative study in patients after myocardial infarction ( author 's transl ) ] . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
2,
16
]
} | {
"id": "C0033429",
"name": "propafenone",
"pos": [
42,
53
]
} |
[ antiarrhythmic efficacy of mexiletine , propafenone and flecainide in ventricular premature beats . a comparative study in patients after myocardial infarction ( author 's transl ) ] . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
2,
16
]
} | {
"id": "C0016229",
"name": "flecainide",
"pos": [
58,
68
]
} |
in 12 patients with coronary artery disease , 11 of them with previous myocardial infarction , the antiarrhythmic effects of orally administered flecainide ( f. ) , mexiletine ( m. ) and propafenone ( p. ) were examined . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
99,
113
]
} | {
"id": "C0016229",
"name": "flecainide",
"pos": [
145,
155
]
} |
in 12 patients with coronary artery disease , 11 of them with previous myocardial infarction , the antiarrhythmic effects of orally administered flecainide ( f. ) , mexiletine ( m. ) and propafenone ( p. ) were examined . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
99,
113
]
} | {
"id": "C0025887",
"name": "mexiletine",
"pos": [
165,
175
]
} |
in 12 patients with coronary artery disease , 11 of them with previous myocardial infarction , the antiarrhythmic effects of orally administered flecainide ( f. ) , mexiletine ( m. ) and propafenone ( p. ) were examined . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
99,
113
]
} | {
"id": "C0033429",
"name": "propafenone",
"pos": [
187,
198
]
} |
cardiovascular and antidepressant effects of imipramine in the treatment of secondary depression in patients with ischemic heart disease . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
19,
33
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
45,
55
]
} |
11 antibacterial drugs , i. e. tobramycin , sisomicin , gentamicin , amicacin , neomycin , carbenicillin , polymyxin m , erythromycin , tetracycline , rifampicin and dioxidine proved to be most active against acinetobacter calcoaceticus . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
3,
16
]
} | {
"id": "C0040341",
"name": "tobramycin",
"pos": [
31,
41
]
} |
11 antibacterial drugs , i. e. tobramycin , sisomicin , gentamicin , amicacin , neomycin , carbenicillin , polymyxin m , erythromycin , tetracycline , rifampicin and dioxidine proved to be most active against acinetobacter calcoaceticus . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
3,
16
]
} | {
"id": "C0027603",
"name": "neomycin",
"pos": [
80,
88
]
} |
11 antibacterial drugs , i. e. tobramycin , sisomicin , gentamicin , amicacin , neomycin , carbenicillin , polymyxin m , erythromycin , tetracycline , rifampicin and dioxidine proved to be most active against acinetobacter calcoaceticus . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
3,
16
]
} | {
"id": "C0006976",
"name": "carbenicillin",
"pos": [
91,
104
]
} |
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