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[ failure to observe the treatment as a source of error in assessing the effect of an antidepressant ( amitriptyline ) on reactive depressions ] . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
86,
100
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
103,
116
]
} |
it combines antidepressant activity with a sedative effect and in this respect resembles amitriptyline , with which it shares a similar profile of clinical action . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
12,
26
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
89,
102
]
} |
fg4963 was found to be significantly inferior as an antidepressant compared to amitryptyline over a 6-week period . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
52,
66
]
} | {
"id": "C0002600",
"name": "amitryptyline",
"pos": [
79,
92
]
} |
there was no significant difference between mortality rates when patients were grouped by anticipated clinical course of underlying disease ( nonfatal , ultimately fatal , and rapidly fatal ) and when they were grouped by type of antibacterial therapy ( appropriate , including clindamycin , chloramphenicol , lincomycin , and carbenicillin ; or inappropriate , signifying no antibiotic treatment or treatment with antibiotics other than the four listed above ) . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
230,
243
]
} | {
"id": "C0008947",
"name": "clindamycin",
"pos": [
278,
289
]
} |
there was no significant difference between mortality rates when patients were grouped by anticipated clinical course of underlying disease ( nonfatal , ultimately fatal , and rapidly fatal ) and when they were grouped by type of antibacterial therapy ( appropriate , including clindamycin , chloramphenicol , lincomycin , and carbenicillin ; or inappropriate , signifying no antibiotic treatment or treatment with antibiotics other than the four listed above ) . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
230,
243
]
} | {
"id": "C0008168",
"name": "chloramphenicol",
"pos": [
292,
307
]
} |
there was no significant difference between mortality rates when patients were grouped by anticipated clinical course of underlying disease ( nonfatal , ultimately fatal , and rapidly fatal ) and when they were grouped by type of antibacterial therapy ( appropriate , including clindamycin , chloramphenicol , lincomycin , and carbenicillin ; or inappropriate , signifying no antibiotic treatment or treatment with antibiotics other than the four listed above ) . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
230,
243
]
} | {
"id": "C0006976",
"name": "carbenicillin",
"pos": [
327,
340
]
} |
a comparison of the anticonvulsant and neurotoxic effects of cannabidiol ( cbd ) , delta 9tetrahydrocannabinol , cannabinol and antiepileptic drugs ( phenytoin , phenobarbital , carbamazepine , chlordiazepoxide , clonazepam , ethosuximide and trimethadione ) was made in rats . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drugs",
"pos": [
128,
147
]
} | {
"id": "C0031507",
"name": "phenytoin",
"pos": [
150,
159
]
} |
a comparison of the anticonvulsant and neurotoxic effects of cannabidiol ( cbd ) , delta 9tetrahydrocannabinol , cannabinol and antiepileptic drugs ( phenytoin , phenobarbital , carbamazepine , chlordiazepoxide , clonazepam , ethosuximide and trimethadione ) was made in rats . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drugs",
"pos": [
128,
147
]
} | {
"id": "C0015043",
"name": "ethosuximide",
"pos": [
226,
238
]
} |
a comparison of the anticonvulsant and neurotoxic effects of cannabidiol ( cbd ) , delta 9tetrahydrocannabinol , cannabinol and antiepileptic drugs ( phenytoin , phenobarbital , carbamazepine , chlordiazepoxide , clonazepam , ethosuximide and trimethadione ) was made in rats . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drugs",
"pos": [
128,
147
]
} | {
"id": "C0041038",
"name": "trimethadione",
"pos": [
243,
256
]
} |
in experiments performed on rats , single subcutaneous doses of predominantly antidopaminergic neuroleptics ( fluspirilene , pimozide , and thioproperazine in large doses ) elicited persistent diestrus , i.e . pseudopregnancy . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
95,
107
]
} | {
"id": "C0031935",
"name": "pimozide",
"pos": [
125,
133
]
} |
chronic treatment of rats with the neuroleptic drugs haloperidol , fluphenazine , and reserpine elicits a 20 to 25 % increase in striatal dopamine receptor binding assayed with [ 3h ] haloperidol . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic drugs",
"pos": [
35,
52
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
184,
195
]
} |
the same effect was caused by the antimalarial drug primaquine , which has not been tested for antiplasmid activity . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial drug",
"pos": [
34,
51
]
} | {
"id": "C0033126",
"name": "primaquine",
"pos": [
52,
62
]
} |
the results suggest that specific neuroleptics ( e.g . pimozide ) may affect the subjective effects induced by narcotics in humans . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
34,
46
]
} | {
"id": "C0031935",
"name": "pimozide",
"pos": [
55,
63
]
} |
perfusion with the antidepressants amitriptyline or maprotiline ( 4.8 micronm ) or mianserin ( 28.8 micronm ) reduced ventricular force , did not change heart rate and only amitriptyline reduced atrial force and lengthened the a-v contraction interval . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
19,
34
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
173,
186
]
} |
a double-blind study was carried out comparing the antidepressant properties of maptotiline ( a new tetracyclic antidepressant ) and amitriptyline . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
51,
65
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
133,
146
]
} |
the compound exerts an antiarrhythmic action in chlorocalcium arrhythmia in rats , in strophanthin-induced one in cats and frogs and the intensity of this action is not inferior to that produced by potassium chloride , quinidine , novacainamide , izoptin and even exceeds it . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
23,
37
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
219,
228
]
} |
in an attempt to find a regimen suitable for pre-hospital prevention of arrhythmias following myocardial infarction , the antiarrhythmic and pharmacokinetic effects of combining intravenous and intramuscular lignocaine have been studied . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
122,
136
]
} | {
"id": "C0023660",
"name": "lignocaine",
"pos": [
208,
218
]
} |
[ antibacterial therapy of urinary tract infections . results of a clinical trial with the combination sulfamoxol/trimethoprim ( = cn 3123 ) ( author 's transl ) ] . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
2,
15
]
} | {
"id": "C0041041",
"name": "trimethoprim",
"pos": [
114,
126
]
} |
psychomotor procedures to distinguish between antidepressant medications : a comparison of the effects of nomifensine maleate , imipramine hc1 , and placebo on the psychomotor performance of normal males [ proceedings ] . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant medications",
"pos": [
46,
72
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
128,
138
]
} |
of antiarrhythmic drugs , a marked and prolonged elevation of the stimulation threshold was produced by procainamide , quinidine , and aimaline . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drugs",
"pos": [
3,
23
]
} | {
"id": "C0033216",
"name": "procainamide",
"pos": [
104,
116
]
} |
of antiarrhythmic drugs , a marked and prolonged elevation of the stimulation threshold was produced by procainamide , quinidine , and aimaline . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drugs",
"pos": [
3,
23
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
119,
128
]
} |
antibacterial activity , pharmacokinetics and efficacy of cefoxitin in patients with abdominal sepsis and other infections . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
0,
13
]
} | {
"id": "C0007557",
"name": "cefoxitin",
"pos": [
58,
67
]
} |
the antidepressant drug amitriptyline and two of its metabolites , nortriptyline and desmethylnortriptyline , each containing two 13c atoms , have been used to determine the sensitivity and selectivity of 13c-nmr spectroscopy for the detection of unchanged amitriptyline and n-desmethyl metabolites in the urine of animals dosed orally with the labelled drug . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant drug",
"pos": [
4,
23
]
} | {
"id": "C0028420",
"name": "nortriptyline",
"pos": [
94,
107
]
} |
the antidepressant drug amitriptyline and two of its metabolites , nortriptyline and desmethylnortriptyline , each containing two 13c atoms , have been used to determine the sensitivity and selectivity of 13c-nmr spectroscopy for the detection of unchanged amitriptyline and n-desmethyl metabolites in the urine of animals dosed orally with the labelled drug . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant drug",
"pos": [
4,
23
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
257,
270
]
} |
effects of neuroleptics on 3h-haloperidol and 3h-cis ( z ) -flupenthixol binding and on adenylate cyclase activity in vitro . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
11,
23
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
30,
41
]
} |
the kinetics of the antibacterial actions of cephalexin and cephaloridin against a strain of escherichia coli and a strain of staphylococcus aureus were studied by a flow microcalorimeter . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
20,
33
]
} | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
45,
55
]
} |
it is concluded that despite the high antiarrhythmic effect of qx-572 , an increase of the lidocaine dose would be safer and preferable in the clinical situation studied . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
38,
52
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
91,
100
]
} |
in the reaction of head twitching ( ht ) in mice in response to 5-oxytryptophan administration in the capacity of a serotonergic model antidepressants chlorimipramine and imipramine and also chlorpheniramine ( suprastin ) expressed a serotonopositive action in doses of 1.0 , 5,0 , and 1.0 mg/kg , respectively . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
135,
150
]
} | {
"id": "C0009010",
"name": "chlorimipramine",
"pos": [
151,
166
]
} |
in the reaction of head twitching ( ht ) in mice in response to 5-oxytryptophan administration in the capacity of a serotonergic model antidepressants chlorimipramine and imipramine and also chlorpheniramine ( suprastin ) expressed a serotonopositive action in doses of 1.0 , 5,0 , and 1.0 mg/kg , respectively . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
135,
150
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
171,
181
]
} |
the effect of neuroleptics ( chlorpromazine , trifluoperazine , haloperidol ) , antidepressants ( amitryptyline , imipramine ) , tranquilizers ( diazepam , chlordiazepoxide , benactyzine ) and stimulant d-amphetamine on the domination and subordination relations formed as a result of competitive behaviour in a pair of rats was studied . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
14,
26
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
64,
75
]
} |
the effect of neuroleptics ( chlorpromazine , trifluoperazine , haloperidol ) , antidepressants ( amitryptyline , imipramine ) , tranquilizers ( diazepam , chlordiazepoxide , benactyzine ) and stimulant d-amphetamine on the domination and subordination relations formed as a result of competitive behaviour in a pair of rats was studied . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
80,
95
]
} | {
"id": "C0002600",
"name": "amitryptyline",
"pos": [
98,
111
]
} |
the effect of neuroleptics ( chlorpromazine , trifluoperazine , haloperidol ) , antidepressants ( amitryptyline , imipramine ) , tranquilizers ( diazepam , chlordiazepoxide , benactyzine ) and stimulant d-amphetamine on the domination and subordination relations formed as a result of competitive behaviour in a pair of rats was studied . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
80,
95
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
114,
124
]
} |
a new type of hydrolyzable ester of penicillin g , benzamidomethyl benzylpenicillinate ( fi 7303 ) , was studied for the antibacterial activity and kinetics of absorption in comparison with dbed-penicillin g . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
121,
134
]
} | {
"id": "C0030827",
"name": "penicillin g",
"pos": [
195,
207
]
} |
it combines antidepressant activity with a sedative effect and has an eeg and clinical activity profile similar to that of amitriptyline . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
12,
26
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
123,
136
]
} |
on the grounds of pharmacological properties and preliminary clinical trials the efficacy of the new antidepressant caroxazone was compared to amitriptyline in the management of depression . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
101,
115
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
143,
156
]
} |
blood level data for the antimalarials amodiaquine , chloroguanide , chloroquine , pyrimethamine , quinine and sulphadoxine have been retrieved from the literature and pharmacokinetically analyzed . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarials",
"pos": [
25,
38
]
} | {
"id": "C0008241",
"name": "chloroguanide",
"pos": [
53,
66
]
} |
blood level data for the antimalarials amodiaquine , chloroguanide , chloroquine , pyrimethamine , quinine and sulphadoxine have been retrieved from the literature and pharmacokinetically analyzed . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarials",
"pos": [
25,
38
]
} | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
69,
80
]
} |
the effect was observed with doses of fluphenazine as low as 0.05 mg/kg , and was also seen after two other neuroleptics , spiroperidol ( 1 mg/kg ) and haloperidol ( 4 mg/kg ) . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
108,
120
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
152,
163
]
} |
the purpose of this study was to determine whether the mucosal alterations of the dorsal rat tongue produced by candida albicans infection were reversible upon treatment with the antifungal drug ketoconazole . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal drug",
"pos": [
179,
194
]
} | {
"id": "C0022625",
"name": "ketoconazole",
"pos": [
195,
207
]
} |
of the 148 study group children , 131 had been exposed in utero to antiepileptic drugs , most commonly phenytoin ( 103 exposed ) . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drugs",
"pos": [
67,
86
]
} | {
"id": "C0031507",
"name": "phenytoin",
"pos": [
103,
112
]
} |
when tested in vivo in the rat vaginal candidiasis model , derivative 18 , although showing significant antifungal activity when compared to controls , was less effective than ketoconazole . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
104,
114
]
} | {
"id": "C0022625",
"name": "ketoconazole",
"pos": [
176,
188
]
} |
in addition to the well-known reduction in the maximal rate of rise the antiarrhythmic agent , lidocaine , also produces a shortening in the duration of the normal ventricular action potential . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agent",
"pos": [
72,
92
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
95,
104
]
} |
bacteriological studies and clinical evaluations of ceftizoxime ( czx ) in perinatal period were carried out , and results are summarised as follows : antibacterial activities of czx in amniotic fluid were determined using the broth dilution method , and bactericidal effect on streptococcus agalactiae , staphylococcus aureus and escherichia coli were demonstrated . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
151,
164
]
} | {
"id": "C0007560",
"name": "czx",
"pos": [
179,
182
]
} |
the outward k+ currents flowing through the modified inward rectifier channels were able to be blocked by the local anesthetic and anti-arrhythmic agent , lidocaine . | therapeutic_class_of | {
"id": "C0003195",
"name": "anti-arrhythmic agent",
"pos": [
131,
152
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
155,
164
]
} |
clinical studies suggest that molindone may be less likely than traditional neuroleptics to induce tardive dyskinesia and that molindone may preferentially ameliorate some negative schizophrenic symptoms . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
76,
88
]
} | {
"id": "C0026388",
"name": "molindone",
"pos": [
127,
136
]
} |
in antidepressant studies , chronic treatment ( 22 days ) with clorgyline attenuated the hypothermic response to 8-oh-dpat , whereas similar duration of treatment with the tricyclics clomipramine and imipramine did not significantly modify it . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
3,
17
]
} | {
"id": "C0009010",
"name": "clomipramine",
"pos": [
183,
195
]
} |
in antidepressant studies , chronic treatment ( 22 days ) with clorgyline attenuated the hypothermic response to 8-oh-dpat , whereas similar duration of treatment with the tricyclics clomipramine and imipramine did not significantly modify it . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
3,
17
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
200,
210
]
} |
[ comparative evaluation of the in vitro and in vivo antibacterial activity of ceftriaxone and piperacillin : determination of the inhibitory quotient in bronchial secretions ] . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
53,
66
]
} | {
"id": "C0007561",
"name": "ceftriaxone",
"pos": [
79,
90
]
} |
[ comparative evaluation of the in vitro and in vivo antibacterial activity of ceftriaxone and piperacillin : determination of the inhibitory quotient in bronchial secretions ] . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
53,
66
]
} | {
"id": "C0031955",
"name": "piperacillin",
"pos": [
95,
107
]
} |
for prevention of infection we used an sd design including antibacterial ( trimethoprim 480 mg/daily , sulfamerazine 720 mg/daily , and polymyxin 0.25 mg/daily ) and antifungal ( 4-6 million iu nystatin/daily ) components . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
59,
72
]
} | {
"id": "C0041041",
"name": "trimethoprim",
"pos": [
75,
87
]
} |
the antibacterial drug nitrofurantoin ( nft ) is notorious for causing hemolytic anemia , which may be related to the methemoglobinemia , another side-effect of nft . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial drug",
"pos": [
4,
22
]
} | {
"id": "C0028156",
"name": "nitrofurantoin",
"pos": [
23,
37
]
} |
analysis of the antimalarial activity of some of these compounds against plasmodium berghei in mice following oral administration again demonstrated activity equal or superior to that of the established antimalarials against a chloroquine-sensitive strain , and in some cases appreciably superior activity against a chloroquine-resistant strain . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarials",
"pos": [
203,
216
]
} | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
316,
327
]
} |
the sulphydryl containing anti-rheumatic drug d-penicillamine mildly inhibited proteoglycan synthesis in cartilage explant cultures by a mechanism not dependent upon h2o2 generation . | therapeutic_class_of | {
"id": "C0003191",
"name": "anti-rheumatic drug",
"pos": [
26,
45
]
} | {
"id": "C0030817",
"name": "penicillamine",
"pos": [
48,
61
]
} |
the sensitivity of microsporum canis , m. gypseum and trichophyton interdigital to the five antifungal agents indicated the efficacy of imidazole compounds as compared to amphotericin b and nystatin . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal agents",
"pos": [
92,
109
]
} | {
"id": "C0002679",
"name": "amphotericin b",
"pos": [
171,
185
]
} |
antipyrine ( ap ) clearance , half-life and volume of distribution were determined in 52 patients , taking one or more antiepileptic drug ( aed ) , before and 4 weeks after the complete removal of phenytoin ( pht , n = 20 ) , carbamazepine ( cbz , n = 15 ) and sodium valproate ( vpa , n = 17 ) . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drug",
"pos": [
119,
137
]
} | {
"id": "C0031507",
"name": "phenytoin",
"pos": [
197,
206
]
} |
antipyrine ( ap ) clearance , half-life and volume of distribution were determined in 52 patients , taking one or more antiepileptic drug ( aed ) , before and 4 weeks after the complete removal of phenytoin ( pht , n = 20 ) , carbamazepine ( cbz , n = 15 ) and sodium valproate ( vpa , n = 17 ) . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drug",
"pos": [
119,
137
]
} | {
"id": "C0037567",
"name": "sodium valproate",
"pos": [
261,
277
]
} |
structure-activity relationships in the classical antidepressant ( imipramine-like ) series show a relative lack of specificities : compounds should simply have a nucleus consisting of two phenyl rings and a third , seven-member central ring . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
50,
64
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
67,
77
]
} |
tianeptine appears to have an original electrophysiological profile in agreement with an increase in serotonin uptake : this profile distinguishes tianeptine from classical antidepressants such as clomipramine . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
173,
188
]
} | {
"id": "C0009010",
"name": "clomipramine",
"pos": [
197,
209
]
} |
( c ) in clinical trials , the double-blind trials confirm the antidepressant efficacy in essentially neurotic depressive syndromes , similar to that of imipramine , nomifensine , amitriptyline . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
63,
77
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
153,
163
]
} |
( c ) in clinical trials , the double-blind trials confirm the antidepressant efficacy in essentially neurotic depressive syndromes , similar to that of imipramine , nomifensine , amitriptyline . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
63,
77
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
180,
193
]
} |
data on the antibacterial activity of cefotetan collected since 1985 have been compiled into a computer database and an analysis of results on more than 100,000 clinical isolates presented . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
12,
25
]
} | {
"id": "C0007555",
"name": "cefotetan",
"pos": [
38,
47
]
} |
considerable progress in treating these infections is being achieved through better application of established available antifungal agents ( amphotericin b , flucytosine , miconazole and ketoconazole ) , and through development of promising investigational agents ( fluconazole , itraconazole ) . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal agents",
"pos": [
121,
138
]
} | {
"id": "C0002679",
"name": "amphotericin b",
"pos": [
141,
155
]
} |
considerable progress in treating these infections is being achieved through better application of established available antifungal agents ( amphotericin b , flucytosine , miconazole and ketoconazole ) , and through development of promising investigational agents ( fluconazole , itraconazole ) . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal agents",
"pos": [
121,
138
]
} | {
"id": "C0016278",
"name": "flucytosine",
"pos": [
158,
169
]
} |
considerable progress in treating these infections is being achieved through better application of established available antifungal agents ( amphotericin b , flucytosine , miconazole and ketoconazole ) , and through development of promising investigational agents ( fluconazole , itraconazole ) . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal agents",
"pos": [
121,
138
]
} | {
"id": "C0025942",
"name": "miconazole",
"pos": [
172,
182
]
} |
considerable progress in treating these infections is being achieved through better application of established available antifungal agents ( amphotericin b , flucytosine , miconazole and ketoconazole ) , and through development of promising investigational agents ( fluconazole , itraconazole ) . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal agents",
"pos": [
121,
138
]
} | {
"id": "C0022625",
"name": "ketoconazole",
"pos": [
187,
199
]
} |
of the 102 strains , 47 ( 46 % ) were resistant to one or more of the following antimicrobial agents : co-trimoxazole , tetracycline , ampicillin , streptomycin , sulphonamide and a combination of ampicillin with sulbactam . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial agents",
"pos": [
80,
100
]
} | {
"id": "C0039644",
"name": "tetracycline",
"pos": [
120,
132
]
} |
all the strains that were resistant to any antimicrobial agents were also resistant to tetracycline . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial agents",
"pos": [
43,
63
]
} | {
"id": "C0039644",
"name": "tetracycline",
"pos": [
87,
99
]
} |
therefore , a combination of ciprofloxacin with an antimicrobial agent active against anaerobes , such as metronidazole , seems to be interesting for the treatment of mixed aerobic/anaerobic infections . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial agent",
"pos": [
51,
70
]
} | {
"id": "C0025872",
"name": "metronidazole",
"pos": [
106,
119
]
} |
the effects of the antidepressant or putative antidepressant drugs desipramine , 2-hydroxy desipramine , nisoxetine , ( s ) -oxaprotiline and ( r ) -oxaprotiline with respect to this release mechanism were investigated in the isolated rat heart submitted to total stop-flow ischemia and subsequent reperfusion . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant drugs",
"pos": [
46,
66
]
} | {
"id": "C0011685",
"name": "desipramine",
"pos": [
91,
102
]
} |
the potency ( pic50 ) of the antidepressants in inhibiting the ischemia-induced ne release varied between 9.16 ( desipramine ) and 6.17 [ ( r ) -oxaprotiline ] . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
29,
44
]
} | {
"id": "C0011685",
"name": "desipramine",
"pos": [
113,
124
]
} |
of 6 antimalarial drugs tested , quinine and quinacrine were the most effective inhibitors and mefloquine was the least effective . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial drugs",
"pos": [
5,
23
]
} | {
"id": "C0025153",
"name": "mefloquine",
"pos": [
95,
105
]
} |
antipsychotic agents associated with extrapyramidal side effects ( setoperone , perlapine , haloperidol , chlorpromazine , and metoclopramide ) increased dopamine release and metabolism at almost every dose tested . | therapeutic_class_of | {
"id": "C0040615",
"name": "antipsychotic agents",
"pos": [
0,
20
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
92,
103
]
} |
the effect of rubidium was similar to that of the antidepressant drugs imipramine and pargyline . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant drugs",
"pos": [
50,
70
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
71,
81
]
} |
studies using central nervous system ( cns ) stimulants ( amphetamines and methylphenidate , deanol , pemoline , caffeine ) , antidepressants ( imipramine and desipramine ) , anticonvulsants ( phenytoin and primidone ) , antianxiety agents ( chlordiazepoxide , hydroxyzine , meprobamate ) , antipsychotic agents ( phenothiazines , thioxanthenes , butyrophenones ) and miscellaneous agents ( benztropine , thyrotropin-releasing hormone , megavitamins ) are discussed . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
126,
141
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
144,
154
]
} |
studies using central nervous system ( cns ) stimulants ( amphetamines and methylphenidate , deanol , pemoline , caffeine ) , antidepressants ( imipramine and desipramine ) , anticonvulsants ( phenytoin and primidone ) , antianxiety agents ( chlordiazepoxide , hydroxyzine , meprobamate ) , antipsychotic agents ( phenothiazines , thioxanthenes , butyrophenones ) and miscellaneous agents ( benztropine , thyrotropin-releasing hormone , megavitamins ) are discussed . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
126,
141
]
} | {
"id": "C0011685",
"name": "desipramine",
"pos": [
159,
170
]
} |
the antiepileptic drug valproic acid was studied in an open clinical trial as adjunct medication for 23 patients with uncontrolled seizures of a generalized or partial type . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drug",
"pos": [
4,
22
]
} | {
"id": "C0042291",
"name": "valproic acid",
"pos": [
23,
36
]
} |
the number of binding sites for tritiated dopamine as well as the affinity of 3h-dopamine for dopamine receptors was studied in rats chronically pretreated with the neuroleptic haloperidol . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
165,
176
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
177,
188
]
} |
neuroleptics ( haloperidol ) closapine , pimozid , chlorpromazine ) diminished the level of free ( functionally active ) form of acetylcholine ( ach ) , and , to some extent , the bound form of ach ; | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
0,
12
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
15,
26
]
} |
this predictable occurrence of ventricular arrhythmias was used to assess the antiarrhythmic effect of lignocaine with particular reference to its effect on the spontaneously occurring reperfusion ventricular fibrillation . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
78,
92
]
} | {
"id": "C0023660",
"name": "lignocaine",
"pos": [
103,
113
]
} |
in contrast , the neuroleptic agents employed ( chlorpormazine , haloperidol , or reserpine ) or alpha-methyl-p-tyrosine tended to exacerbate the withdrawal syndrome . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic agents",
"pos": [
18,
36
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
65,
76
]
} |
we report a study of the comparison of antiepileptic drugs ( phenobarbital , phenytoin , primidone , and carbamazepine ) by the enzyme multiplied immunoassay technique `` '' emit '' '' and the gas chromatography ( glc ) method . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drugs",
"pos": [
39,
58
]
} | {
"id": "C0031507",
"name": "phenytoin",
"pos": [
77,
86
]
} |
we report a study of the comparison of antiepileptic drugs ( phenobarbital , phenytoin , primidone , and carbamazepine ) by the enzyme multiplied immunoassay technique `` '' emit '' '' and the gas chromatography ( glc ) method . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drugs",
"pos": [
39,
58
]
} | {
"id": "C0033148",
"name": "primidone",
"pos": [
89,
98
]
} |
disopyramide is a new antiarrhythmic drug with a pharmacological profile of action similar to that of quinidine and procainamide . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
22,
36
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
102,
111
]
} |
disopyramide is a new antiarrhythmic drug with a pharmacological profile of action similar to that of quinidine and procainamide . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
22,
36
]
} | {
"id": "C0033216",
"name": "procainamide",
"pos": [
116,
128
]
} |
like other antiarrhythmic agents , disopyramide exerts a negative inotropic action on cardiac muscle , and development of acute heart failure has been reported . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agents",
"pos": [
11,
32
]
} | {
"id": "C0012702",
"name": "disopyramide",
"pos": [
35,
47
]
} |
a comparative trial was carried out in 4 orphanges in seoul , to compare the anthelminthic efficacy of oxantel-pyrantel suspension and mebendazole tablets against mixed infections of ascaris lumbricoides and trichuris trichiura . | therapeutic_class_of | {
"id": "C0003158",
"name": "anthelminthic",
"pos": [
77,
90
]
} | {
"id": "C0025023",
"name": "mebendazole",
"pos": [
135,
146
]
} |
the results taken together with other recent data support the hypothesis that melperone may be a type iii anti-arrhythmic according to the classification of vaughan williams , in contrast to thioridazine which has a quinidine-like action ( type i ) . | therapeutic_class_of | {
"id": "C0003195",
"name": "anti-arrhythmic",
"pos": [
106,
121
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
216,
225
]
} |
therapeutically the organic fluorides include the neuroleptics trifluoperazine , fluphenazine , triflupromazine , and haloperidol , the benzodiazepine flurazepam and the polyfluorinated inhalant convulsant indoklon . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
50,
62
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
118,
129
]
} |
a rapid , sensitive and specific gas-liquid chromatographic method is presented for the routine monitoring of plasma concentrations of the anti-arrhythmic compound , disopyramide . | therapeutic_class_of | {
"id": "C0003195",
"name": "anti-arrhythmic",
"pos": [
139,
154
]
} | {
"id": "C0012702",
"name": "disopyramide",
"pos": [
166,
178
]
} |
the influence of probenecid on the concentrations in blood and antibacterial efficacy of cephradine was studied in experimentally infected mice . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
63,
76
]
} | {
"id": "C0007738",
"name": "cephradine",
"pos": [
89,
99
]
} |
changes in frp after the administration of antiarrhythmic drugs ( lidocaine and quinidine ) or due to changes in heart rate were predicted accurately . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
43,
57
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
66,
75
]
} |
changes in frp after the administration of antiarrhythmic drugs ( lidocaine and quinidine ) or due to changes in heart rate were predicted accurately . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
43,
57
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
80,
89
]
} |
ciclazindol , a new tetracyclic compound , appears to be a potentially important antidepressant of the same order as amitriptyline , but with significantly fewer subjective side effects . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
81,
95
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
117,
130
]
} |
the antibacterial activity of cefazolin , cephacetrile , and cephradine against e. coli and klebsiella strains was also investigated , in a medium containing 4 % human albumin , simulating the serum level curves observed in humans after an intramuscular dose of 1 g . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0007546",
"name": "cefazolin",
"pos": [
30,
39
]
} |
the antibacterial activity of cefazolin , cephacetrile , and cephradine against e. coli and klebsiella strains was also investigated , in a medium containing 4 % human albumin , simulating the serum level curves observed in humans after an intramuscular dose of 1 g . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0007738",
"name": "cephradine",
"pos": [
61,
71
]
} |
antibacterial activity of apalcillin ( pc-904 ) against gram-negative bacilli , especially ampicillin- , carbenicillin- , and gentamicin-resistant clinical isolates . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
0,
13
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
91,
101
]
} |
antibacterial activity of apalcillin ( pc-904 ) against gram-negative bacilli , especially ampicillin- , carbenicillin- , and gentamicin-resistant clinical isolates . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
0,
13
]
} | {
"id": "C0006976",
"name": "carbenicillin",
"pos": [
105,
118
]
} |
sk & f 75073 , a new parenteral cephalosporin , was found to have broad in vitro and in vivo antibacterial activity including isolates usually resistant to cephalothin and cefazolin . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
93,
106
]
} | {
"id": "C0007546",
"name": "cefazolin",
"pos": [
172,
181
]
} |
we examined the antibacterial activity of penicillin g potassium , 100 microgram/ml , cefazolin sodium , 100 microgram/ml , and gentamicin sulfate , 20 microgram/ml against test organisms in m-k medium at 4 degrees , 23 degrees , and 37 degrees c for periods up to 18 hours . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
16,
29
]
} | {
"id": "C0700462",
"name": "penicillin g potassium",
"pos": [
42,
64
]
} |
we examined the antibacterial activity of penicillin g potassium , 100 microgram/ml , cefazolin sodium , 100 microgram/ml , and gentamicin sulfate , 20 microgram/ml against test organisms in m-k medium at 4 degrees , 23 degrees , and 37 degrees c for periods up to 18 hours . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
16,
29
]
} | {
"id": "C0700526",
"name": "cefazolin sodium",
"pos": [
86,
102
]
} |
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