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cefaclor showed good antibacterial activity against strains which were resistant to the orally administrable agents ampicillin , tetracycline and co-trimoxazole . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
21,
34
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
116,
126
]
} |
on the basis of data from a variety of studies , the useful antibacterial spectrum of cefaclor is shown to include all classes of bacteria that are generally susceptible to cephalothin and cephalexin . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
60,
73
]
} | {
"id": "C0007537",
"name": "cefaclor",
"pos": [
86,
94
]
} |
on the basis of data from a variety of studies , the useful antibacterial spectrum of cefaclor is shown to include all classes of bacteria that are generally susceptible to cephalothin and cephalexin . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
60,
73
]
} | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
189,
199
]
} |
anthelmintic trials were carried out to evaluate the efficacy of albendazole against helmi of 2,5 to 3,8 mg/kg administered orally , resulted in a 98,8 to 100 % reduction of adult parasites of the genera haemonchus , ostertagia , trichostrongylus , nematodirus , gaigeria , oesophagostomum , chabertia , marshallagia and cooperia . | therapeutic_class_of | {
"id": "C0003158",
"name": "anthelmintic",
"pos": [
0,
12
]
} | {
"id": "C0001911",
"name": "albendazole",
"pos": [
65,
76
]
} |
the mutagenic and metabolic properties of largely used products ( e.g . an antibacterial drug containing nitrofurantoin and laboratory reagents containing sodium azide ) have been also checked . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial drug",
"pos": [
75,
93
]
} | {
"id": "C0028156",
"name": "nitrofurantoin",
"pos": [
105,
119
]
} |
[ antidepressant action of sam in comparison to chlorimipramine . hypotheses to interpret the mechanism of action ] . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
2,
16
]
} | {
"id": "C0009010",
"name": "chlorimipramine",
"pos": [
48,
63
]
} |
the collected strains were tested with disks of nine antibacterial drugs in common use : the survey detected sensitivity of all the strains to cephaloridine , ampicillin , carbenicillin , kanamycin and gentamicin , whereas a fair percentage of resistance appeared to streptomycin , tetracycline , chloramphenicol and cotrimoxazole . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial drugs",
"pos": [
53,
72
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
159,
169
]
} |
the collected strains were tested with disks of nine antibacterial drugs in common use : the survey detected sensitivity of all the strains to cephaloridine , ampicillin , carbenicillin , kanamycin and gentamicin , whereas a fair percentage of resistance appeared to streptomycin , tetracycline , chloramphenicol and cotrimoxazole . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial drugs",
"pos": [
53,
72
]
} | {
"id": "C0006976",
"name": "carbenicillin",
"pos": [
172,
185
]
} |
the collected strains were tested with disks of nine antibacterial drugs in common use : the survey detected sensitivity of all the strains to cephaloridine , ampicillin , carbenicillin , kanamycin and gentamicin , whereas a fair percentage of resistance appeared to streptomycin , tetracycline , chloramphenicol and cotrimoxazole . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial drugs",
"pos": [
53,
72
]
} | {
"id": "C0022487",
"name": "kanamycin",
"pos": [
188,
197
]
} |
the collected strains were tested with disks of nine antibacterial drugs in common use : the survey detected sensitivity of all the strains to cephaloridine , ampicillin , carbenicillin , kanamycin and gentamicin , whereas a fair percentage of resistance appeared to streptomycin , tetracycline , chloramphenicol and cotrimoxazole . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial drugs",
"pos": [
53,
72
]
} | {
"id": "C0038425",
"name": "streptomycin",
"pos": [
267,
279
]
} |
the collected strains were tested with disks of nine antibacterial drugs in common use : the survey detected sensitivity of all the strains to cephaloridine , ampicillin , carbenicillin , kanamycin and gentamicin , whereas a fair percentage of resistance appeared to streptomycin , tetracycline , chloramphenicol and cotrimoxazole . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial drugs",
"pos": [
53,
72
]
} | {
"id": "C0008168",
"name": "chloramphenicol",
"pos": [
297,
312
]
} |
the antibacterial activity of cefazolin , cephacetrile , and cephradine against an e. coli strains was also investigated , in a medium containing 4 % human albumin , simulating the serum level curves observed in humans after an intramuscular dose of 1 g . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0007546",
"name": "cefazolin",
"pos": [
30,
39
]
} |
the antibacterial activity of cefazolin , cephacetrile , and cephradine against an e. coli strains was also investigated , in a medium containing 4 % human albumin , simulating the serum level curves observed in humans after an intramuscular dose of 1 g . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0007738",
"name": "cephradine",
"pos": [
61,
71
]
} |
currently used antiarrhythmic drugs did not interfere with the analysis of disopyramide , and the pharmacokinetics of the drug , obtained from studies of one subject , agree well with reported values . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drugs",
"pos": [
15,
35
]
} | {
"id": "C0012702",
"name": "disopyramide",
"pos": [
75,
87
]
} |
subsequent experiments performed with a neuroleptic ( haloperidol ) or a serotonin precursor ( 5-oh-tryptophan ) compared to those of d-lsd with and without apomorphine would indicate that d-lsd alone displays typical serotoninergic syndrome ( including inhibition of the climbing ) , whereas in the presence of apomorphine , an interaction at presynaptic receptors may possibly modulate dopaminergic activity . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
40,
51
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
54,
65
]
} |
we discuss fluotracen in relation to other neuroleptics and thymoleptics , and we suggest that comparative studies with thiothixene might be informative . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
43,
55
]
} | {
"id": "C0039955",
"name": "thiothixene",
"pos": [
120,
131
]
} |
[ determination in vitro of the antibacterial action of rifampicin ( sinerdol ) as compared to other antibiotics ] . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
32,
45
]
} | {
"id": "C0035608",
"name": "rifampicin",
"pos": [
56,
66
]
} |
no interference with the antibacterial activity of ceftazidime or with the cytotoxic activity of mitoxantrone was observed . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
25,
38
]
} | {
"id": "C0007559",
"name": "ceftazidime",
"pos": [
51,
62
]
} |
quinolone resistance achieved in in vitro-selected mutants qr-1 and qr-2 was associated with cross-resistance to several groups of antimicrobial agents , including beta-lactams , tetracycline , and chloramphenicol . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial",
"pos": [
131,
144
]
} | {
"id": "C0039644",
"name": "tetracycline",
"pos": [
179,
191
]
} |
the antiarrhythmic activity of flecainide has been tested in seven old patients ( mean age 71 years ) suffering from recurrent episodes of ventricular tachycardia . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
4,
18
]
} | {
"id": "C0016229",
"name": "flecainide",
"pos": [
31,
41
]
} |
ticarcillin-clavulanic acid showed superior antibacterial activity compared to penicillin , mezlocillin , piperacillin , ticarcillin , gentamicin , and amikacin against bacteremic isolates of methicillin-susceptible staphylococcus aureus and staphylococcus epidermidis . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
44,
57
]
} | {
"id": "C0031955",
"name": "piperacillin",
"pos": [
106,
118
]
} |
ticarcillin-clavulanic acid showed superior antibacterial activity compared to penicillin , mezlocillin , piperacillin , ticarcillin , gentamicin , and amikacin against bacteremic isolates of methicillin-susceptible staphylococcus aureus and staphylococcus epidermidis . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
44,
57
]
} | {
"id": "C0040193",
"name": "ticarcillin",
"pos": [
121,
132
]
} |
ticarcillin-clavulanic acid showed superior antibacterial activity compared to penicillin , mezlocillin , piperacillin , ticarcillin , gentamicin , and amikacin against bacteremic isolates of methicillin-susceptible staphylococcus aureus and staphylococcus epidermidis . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
44,
57
]
} | {
"id": "C0002499",
"name": "amikacin",
"pos": [
152,
160
]
} |
the authors considered the antibacterial activity of dactimicin compared with amikacin , gentamicin and the fortimicins against gram-positive and gram-negative bacteria . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
27,
40
]
} | {
"id": "C0002499",
"name": "amikacin",
"pos": [
78,
86
]
} |
this discussion will concentrate on the new antifungal drugs of the past ten years , with the exception of developments in the polyenes and flucytosine , which are covered elsewhere . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
44,
54
]
} | {
"id": "C0016278",
"name": "flucytosine",
"pos": [
140,
151
]
} |
currently , new antifungal agents and galenic preparations of amphotericin b are being evaluated with the aim of improving the prognosis of candidiasis in immunocompromised hosts . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
16,
26
]
} | {
"id": "C0002679",
"name": "amphotericin b",
"pos": [
62,
76
]
} |
the effects of single or repeated doses of antidepressant drugs ( imipramine , amitriptyline , citalopram , mianserin ) on rat locomotor hyperactivity induced by quinpirole , a dopamine d-2 receptor agonist , was investigated . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
43,
57
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
66,
76
]
} |
the effects of single or repeated doses of antidepressant drugs ( imipramine , amitriptyline , citalopram , mianserin ) on rat locomotor hyperactivity induced by quinpirole , a dopamine d-2 receptor agonist , was investigated . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
43,
57
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
79,
92
]
} |
a set of test ( general behavior , traction , chimney , rotarod , conditioned reflexes , curiosity and potentiation of barbiturate sleep ) were given in addition to studying the hypothermia of associations of chlorpromazine with various neuroleptic and one anxiolytic ( perphenazine , clothiapine , haloperidol and diazepam ) , which demonstrated an evident enhancement of the depressant effects of chlorpromazine when combined with clothiapine and haloperidol . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
237,
248
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
449,
460
]
} |
a multicenter study compared the antidepressant efficacy and the tolerance of two doses of milnacipran ( 50 mg and 100 mg/day ) and amitriptyline ( 150 mg/day ) in three parallel groups of 45 major depressive inpatients defined by research diagnostic criteria . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
33,
47
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
132,
145
]
} |
however , no oral antifungal agent is as yet available for the prevention of pulmonary aspergillosis , as ketoconazole has proved ineffective . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal agent",
"pos": [
18,
34
]
} | {
"id": "C0022625",
"name": "ketoconazole",
"pos": [
106,
118
]
} |
the obtained antipropulsive/antidiarrheal potency ratios varied from 0.71 to greater than 552 [ pethidine ( oral ed50 's in mg/kg : 21.5/30.2 ) , fentanyl ( 0.77/0.49 ) , dextromoramide ( 5.39/2.90 ) , methadone ( 14.2/6.38 ) , codeine ( 98.4/10.8 ) , morphine ( 56.6/5.21 ) , diphenoxylate ( 8.15/0.54 ) , nufenoxole ( 74.7/1.72 ) , difenoxin ( 7.10/0.16 ) , loperamide oxide ( greater than 160/0.34 ) and loperamide ( greater than 160/0.29 ) ] . | therapeutic_class_of | {
"id": "C0003292",
"name": "antidiarrheal",
"pos": [
28,
41
]
} | {
"id": "C0012525",
"name": "diphenoxylate",
"pos": [
277,
290
]
} |
in spite of the difficulties in the clinical evaluation of new antiepileptic drug , a reduction in seizure frequency was reported following the addition of vigabatrin to the concomitant medication in all studies . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic",
"pos": [
63,
76
]
} | {
"id": "C0048044",
"name": "vigabatrin",
"pos": [
156,
166
]
} |
the lack of tachyphylaxis to the antiepileptic effect of vigabatrin is shown by the small number of patients who discontinued for insufficient efficacy ( 11 % ) , two thirds of them during the first 6 months of follow-up . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic",
"pos": [
33,
46
]
} | {
"id": "C0048044",
"name": "vigabatrin",
"pos": [
57,
67
]
} |
to exploit the antiarrhythmic effect of amiodarone when patients develop the side effect of thyrotoxicosis three patients with hyperthyroidism induced by amiodarone were given simultaneously 1 g potassium perchlorate a day for 40 days and a starting dose of 40 mg methimazole a day while they continued to take amiodarone . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
15,
29
]
} | {
"id": "C0002598",
"name": "amiodarone",
"pos": [
311,
321
]
} |
study on the relationship between pharmacokinetics and antibacterial activity : comparison between ceftriaxone and cefotaxime within the respiratory tract . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
55,
68
]
} | {
"id": "C0007561",
"name": "ceftriaxone",
"pos": [
99,
110
]
} |
study on the relationship between pharmacokinetics and antibacterial activity : comparison between ceftriaxone and cefotaxime within the respiratory tract . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
55,
68
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
115,
125
]
} |
the aim of this research was to collect precise data on the antibacterial activity of ceftriaxone and cefotaxime in the respiratory tract . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
60,
73
]
} | {
"id": "C0007561",
"name": "ceftriaxone",
"pos": [
86,
97
]
} |
the aim of this research was to collect precise data on the antibacterial activity of ceftriaxone and cefotaxime in the respiratory tract . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
60,
73
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
102,
112
]
} |
the antibacterial protection afforded by cefotaxime , given at the dosage of 1 g ( i.m . ) every 12 h , was not as marked and did not extend over the interval between two administrations . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
41,
51
]
} |
three diverse mechanisms have been proposed to explain the antimalarial activity of chloroquine : binding to dna , binding to hemin , or alkalinizing parasite lysosomes . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial",
"pos": [
59,
71
]
} | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
84,
95
]
} |
nevertheless , because of the large number of sites present , binding to parasite dna may still account for the antimalarial activity of chloroquine . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial",
"pos": [
112,
124
]
} | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
137,
148
]
} |
the behaviour of epidermophyton stockdaleae against antifungal agents tested is clearly different from that observed in the strains belonging to epidermophyton floccosum , since all of the latter were sensitive to the antifungal agents used and the geophilic species showed resistance to griseofulvin , isoconazole , natamycin and nystatin , and intermediate sensitivity to ketoconazole and miconazole . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal agents",
"pos": [
52,
69
]
} | {
"id": "C0022625",
"name": "ketoconazole",
"pos": [
374,
386
]
} |
the behaviour of epidermophyton stockdaleae against antifungal agents tested is clearly different from that observed in the strains belonging to epidermophyton floccosum , since all of the latter were sensitive to the antifungal agents used and the geophilic species showed resistance to griseofulvin , isoconazole , natamycin and nystatin , and intermediate sensitivity to ketoconazole and miconazole . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal agents",
"pos": [
52,
69
]
} | {
"id": "C0025942",
"name": "miconazole",
"pos": [
391,
401
]
} |
the effect of the antimalarial drug chloroquine on the carbachol-induced down-regulation of muscarinic acetylcholine receptors ( machrs ) was studied in the neuroblastoma-glioma hybrid ng108-15 cells . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial",
"pos": [
18,
30
]
} | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
36,
47
]
} |
[ bone and suppurative lesion distribution of antimicrobial agents ( ampicillin and ofloxacin ) in experimental infected rabbits ] . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial agents",
"pos": [
46,
66
]
} | {
"id": "C0028902",
"name": "ofloxacin",
"pos": [
84,
93
]
} |
the antimicrobials used were metronidazole for the first 2 mixtures and tetracycline for the last . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobials",
"pos": [
4,
18
]
} | {
"id": "C0025872",
"name": "metronidazole",
"pos": [
29,
42
]
} |
the antimicrobials used were metronidazole for the first 2 mixtures and tetracycline for the last . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobials",
"pos": [
4,
18
]
} | {
"id": "C0039644",
"name": "tetracycline",
"pos": [
72,
84
]
} |
supported by antimicrobial therapy with erythromycin and rifampicin the lung function could be improved to `` '' restitutio ad integrum '' '' . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial",
"pos": [
13,
26
]
} | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
40,
52
]
} |
the most active antimicrobial agents were piperacillin and minocycline , followed ( in descending order of activity ) by moxalactam , erythromycin , cefoperazone , tetracycline , ampicillin , cefotaxime , chloramphenicol , josamycin , sulfamethoxazole , and nalidixic acid . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial agents",
"pos": [
16,
36
]
} | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
134,
146
]
} |
the most active antimicrobial agents were piperacillin and minocycline , followed ( in descending order of activity ) by moxalactam , erythromycin , cefoperazone , tetracycline , ampicillin , cefotaxime , chloramphenicol , josamycin , sulfamethoxazole , and nalidixic acid . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial agents",
"pos": [
16,
36
]
} | {
"id": "C0039644",
"name": "tetracycline",
"pos": [
164,
176
]
} |
the most active antimicrobial agents were piperacillin and minocycline , followed ( in descending order of activity ) by moxalactam , erythromycin , cefoperazone , tetracycline , ampicillin , cefotaxime , chloramphenicol , josamycin , sulfamethoxazole , and nalidixic acid . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial agents",
"pos": [
16,
36
]
} | {
"id": "C0038689",
"name": "sulfamethoxazole",
"pos": [
235,
251
]
} |
the in vitro antibacterial activity of the antifungal compound fenticonazole was compared with those of clotrimazole , miconazole , tetracycline , and metronidazole against 177 strains of bacterial species associated with either bacterial vaginosis ( bv ) or skin infections by agar dilution mic determinations . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
43,
53
]
} | {
"id": "C0025942",
"name": "miconazole",
"pos": [
119,
129
]
} |
antiarrhythmic drugs had to be added in 6 patients in the placebo-treated group ( n = 16 ) , but in none in the flecainide-treated group ( n = 14 ) ( p less than 0.01 ) . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
0,
14
]
} | {
"id": "C0016229",
"name": "flecainide",
"pos": [
112,
122
]
} |
the results can account for the antiarrhythmic actions of disopyramide during a rapid tachycardia and prevention of its initiation by programmed electrical stimulation . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
32,
46
]
} | {
"id": "C0012702",
"name": "disopyramide",
"pos": [
58,
70
]
} |
the neuroleptic drug haloperidol produces similar effects in these areas as well as in frontal cortex , but is considerably more potent than dt gamma e . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic drug",
"pos": [
4,
20
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
21,
32
]
} |
the efficacy of seven more recently developed anthelmintics of the benzimidazolecarbamate group , i. e. , parbendazole , mebendazole , fenbendazole , oxibendazole , cambendazole , oxfendazole and albendazole , has been tested in a series of experiments on white mice artifically infected with trichinella spiralis . | therapeutic_class_of | {
"id": "C0003158",
"name": "anthelmintics",
"pos": [
46,
59
]
} | {
"id": "C0025023",
"name": "mebendazole",
"pos": [
121,
132
]
} |
the efficacy of seven more recently developed anthelmintics of the benzimidazolecarbamate group , i. e. , parbendazole , mebendazole , fenbendazole , oxibendazole , cambendazole , oxfendazole and albendazole , has been tested in a series of experiments on white mice artifically infected with trichinella spiralis . | therapeutic_class_of | {
"id": "C0003158",
"name": "anthelmintics",
"pos": [
46,
59
]
} | {
"id": "C0001911",
"name": "albendazole",
"pos": [
196,
207
]
} |
this effect is prevented by neuroleptic agents such as chlorpromazine and haloperidol which would suggest that released dopamine may be involved in the response . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic agents",
"pos": [
28,
46
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
74,
85
]
} |
chronic ( 14 days ) but not acute treatment with antidepressants ( amitriptyline , imipramine , desipramine , clomipramine , mianserin , danitracen , iprindole ) potentiated the aggressive behaviour induced by apomorphine ( apo ) in rats . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
49,
64
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
67,
80
]
} |
chronic ( 14 days ) but not acute treatment with antidepressants ( amitriptyline , imipramine , desipramine , clomipramine , mianserin , danitracen , iprindole ) potentiated the aggressive behaviour induced by apomorphine ( apo ) in rats . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
49,
64
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
83,
93
]
} |
chronic ( 14 days ) but not acute treatment with antidepressants ( amitriptyline , imipramine , desipramine , clomipramine , mianserin , danitracen , iprindole ) potentiated the aggressive behaviour induced by apomorphine ( apo ) in rats . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
49,
64
]
} | {
"id": "C0011685",
"name": "desipramine",
"pos": [
96,
107
]
} |
chronic ( 14 days ) but not acute treatment with antidepressants ( amitriptyline , imipramine , desipramine , clomipramine , mianserin , danitracen , iprindole ) potentiated the aggressive behaviour induced by apomorphine ( apo ) in rats . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
49,
64
]
} | {
"id": "C0009010",
"name": "clomipramine",
"pos": [
110,
122
]
} |
[ the ultrastructural changes of synapses in rat following long-term administration of the neuroleptics , reserpine and haloperidol ( author 's transl ) ] . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
91,
103
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
120,
131
]
} |
[ studies on the serum levels of the antiepileptic drugs-with particular reference to diphenylhydantoin , phenobarbital and carbamazepine- ( author 's transl ) ] . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drugs",
"pos": [
37,
56
]
} | {
"id": "C0031507",
"name": "diphenylhydantoin",
"pos": [
86,
103
]
} |
groups of six rats per dose were trained and 24 h later pretreated , 5 min before metrazol , with an ip injection of the following antiepileptics ( dose range in mg/kg ) : ethosuximide ( 20 -- 320 ) ; | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptics",
"pos": [
131,
145
]
} | {
"id": "C0015043",
"name": "ethosuximide",
"pos": [
172,
184
]
} |
the antifungal properties of fungizone ( amphotericin b intravenous solution ) and thiabendazole on histoplasma capsulatum within guinea pig macrophages were compared using the staining method and a newly developed plating method to determine the viability of intracellular h. capsulatum . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
4,
14
]
} | {
"id": "C0002679",
"name": "amphotericin b",
"pos": [
41,
55
]
} |
the anthelmintics bithionol , phenothiazine , albendazole and fenbendazole were oxidized to sulphoxides by enzymes in the cytosol of the proglottids of the cestode moniezia expansa and the cytosol of the intestinal epithelial cells of the nematode ascaris suum . | therapeutic_class_of | {
"id": "C0003158",
"name": "anthelmintics",
"pos": [
4,
17
]
} | {
"id": "C0001911",
"name": "albendazole",
"pos": [
46,
57
]
} |
despite the fact that these solvents have a lower antiarrhythmic potency , their therapeutic index is 5- to 50-fold greater than quinidine and/or procainamide . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
50,
64
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
129,
138
]
} |
despite the fact that these solvents have a lower antiarrhythmic potency , their therapeutic index is 5- to 50-fold greater than quinidine and/or procainamide . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
50,
64
]
} | {
"id": "C0033216",
"name": "procainamide",
"pos": [
146,
158
]
} |
10 healthy lactating women were treated orally with the anthelmintic praziquantel ( biltricide ) , and the resulting timedependent concentrations of the unchanged substance in plasma and milk were determined simultaneously . | therapeutic_class_of | {
"id": "C0003158",
"name": "anthelmintic",
"pos": [
56,
68
]
} | {
"id": "C0032911",
"name": "praziquantel",
"pos": [
69,
81
]
} |
a double-blind trial was undertaken to compare the antidepressant efficacy and the side effects of lofepramine with those of amitriptyline in the treatment of endogenous depression . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
51,
65
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
125,
138
]
} |
a 60-year-old patient with coronary artery disease and antecedent ( 1976 ) myocardial infarction developed sinus standstill with nodal bradycardia of 41/min while on antiarrhythmic treatment with lidocain ( 2 mg/min drip infusion ) . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
166,
180
]
} | {
"id": "C0023660",
"name": "lidocain",
"pos": [
196,
204
]
} |
comparison of antibacterial activity of a new cephalosporin , ceftizoxime ( fk 749 ) with other cephalosporin antibiotics . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
14,
27
]
} | {
"id": "C0007560",
"name": "ceftizoxime",
"pos": [
62,
73
]
} |
the antibacterial activity of fk 749 against pseudomonas aeruginosa was almost the same as that of ticarcillin but was inferior to that of gentamicin and t 1551 . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0040193",
"name": "ticarcillin",
"pos": [
99,
110
]
} |
the antiarrhythmic effect of flecainide acetate ( fcn ) , a newly developed class i antiarrhythmic drug , was evaluated on epinephrine ( e ) -halothane induced arrhythmias in dogs . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
4,
18
]
} | {
"id": "C0086303",
"name": "flecainide acetate",
"pos": [
29,
47
]
} |
although quinine and its congener chloroquine have been used as antimalarials for many years , and their analog , mefloquine , has been recently introduced , the precise mode of action of these quinoline-containing drugs is not fully understood . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarials",
"pos": [
64,
77
]
} | {
"id": "C0025153",
"name": "mefloquine",
"pos": [
114,
124
]
} |
in vivo spectrophotometric determination of striatal acetylcholinesterase activity : the modulation induced by the antidepressant amitriptyline . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
115,
129
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
130,
143
]
} |
this additional action probably accounts for the greater antiarrhythmic efficacy of sotalol compared with other beta blockers . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
57,
71
]
} | {
"id": "C0037707",
"name": "sotalol",
"pos": [
84,
91
]
} |
in a recent double-blind , placebo-controlled , parallel study , the antiarrhythmic effects of sotalol and propranolol were compared in 172 patients with greater than 30 vpcs/hour . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
69,
83
]
} | {
"id": "C0037707",
"name": "sotalol",
"pos": [
95,
102
]
} |
these findings indicate that the antiarrhythmic effects of sotalol are comparable to those of class i agents in treating malignant arrhythmias . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
33,
47
]
} | {
"id": "C0037707",
"name": "sotalol",
"pos": [
59,
66
]
} |
the concentrations at which amiodarone- or desethylamiodarone-induced electron microscopic changes and hepatotoxicity were only two to five times as high as the usual serum drug levels in patients given antiarrhythmic therapy with amiodarone . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
203,
217
]
} | {
"id": "C0002598",
"name": "amiodarone",
"pos": [
231,
241
]
} |
this study was designed to compare the antidepressant effects of alprazolam and amitriptyline in a group of 30 inpatients suffering from a severe major endogenous depression , diagnosed by research diagnostic criteria and the newcastle rating scale , and to examine the effects of alprazolam and amitriptyline on two biological markers of depression , the dexamethasone suppression test and sleep eeg parameters . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
39,
53
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
296,
309
]
} |
after 4 weeks of treatment the antidepressant effects of amitriptyline significantly exceeded those of alprazolam , as measured on the hamilton rating scale for depression . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
31,
45
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
57,
70
]
} |
the initial doses of amiodarone averaged 845 +/- 258 mg for the first 2 weeks and 56 % of all patients received a type i antiarrhythmic drug in addition to amiodarone during the initial phase of therapy . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drug",
"pos": [
121,
140
]
} | {
"id": "C0002598",
"name": "amiodarone",
"pos": [
156,
166
]
} |
three of the tested antiarrhythmics , namely the lipophilic amiodarone , aprindine and asocainol , were very potent antioxidants , and a further investigation of concentration and time dependency of lipid peroxidation was performed . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmics",
"pos": [
20,
35
]
} | {
"id": "C0002598",
"name": "amiodarone",
"pos": [
60,
70
]
} |
the antiarrhythmic effectiveness and safety of 12-h oral administration of mexiletine were evaluated in adult outpatients with a baseline hourly rate of pvcs of 30 or higher who had initially shown at least a 50 percent reduction of this rate when treated with mexiletine at an 8-h dosage interval . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
4,
18
]
} | {
"id": "C0025887",
"name": "mexiletine",
"pos": [
261,
271
]
} |
antimicrobial therapy consisted of cefoperazone , cefoperazone plus sulbactam , ciprofloxacin , clindamycin , metronidazole ( against the gram-negative anaerobes ) , or penicillin g ( against the gram-positive anaerobes ) , beginning 4 hours after organism inoculation and continuing every 6 hours for 16 doses . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial",
"pos": [
0,
13
]
} | {
"id": "C0008809",
"name": "ciprofloxacin",
"pos": [
80,
93
]
} |
antimicrobial therapy consisted of cefoperazone , cefoperazone plus sulbactam , ciprofloxacin , clindamycin , metronidazole ( against the gram-negative anaerobes ) , or penicillin g ( against the gram-positive anaerobes ) , beginning 4 hours after organism inoculation and continuing every 6 hours for 16 doses . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial",
"pos": [
0,
13
]
} | {
"id": "C0025872",
"name": "metronidazole",
"pos": [
110,
123
]
} |
at the end of the study in vivo organisms were reduced by at least 3 log10 cfu/ml from drug-free growth control chambers by all the antimicrobial regimens tested except for cefoperazone against b. fragilis and ciprofloxacin against the three isolates tested . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial",
"pos": [
132,
145
]
} | {
"id": "C0008809",
"name": "ciprofloxacin",
"pos": [
210,
223
]
} |
twenty-four cancer patients with diffuse interstitial pneumonitis ( dip ) were randomized to undergo an open lung biopsy ( olb ) within 8 hours of presentation ( 12 patients ) or to receive empiric antimicrobial therapy ( et ) with trimethoprim-sulfamethoxazole ( tmp-smx ) erythromycin for a minimum of 4 days ( 12 patients ) . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial",
"pos": [
198,
211
]
} | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
274,
286
]
} |
antidepressant binding sites in brain : autoradiographic comparison of [ 3h ] paroxetine and [ 3h ] imipramine localization and relationship to serotonin transporter . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
0,
14
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
100,
110
]
} |
binding of two different antidepressant drugs , [ 3h ] paroxetine and [ 3h ] imipramine in 30 rat brain regions was visualized , compared and quantified by means of autoradiography and densitometry . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
25,
39
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
77,
87
]
} |
as of 1989 , the psychotropic drugs that have been reported to inhibit female orgasm include antipsychotic agents ( thioridazine , trifluoperazine and fluphenazine ) , the combination drug perphenazine/amitriptyline , antidepressants ( phenelzine , isocarboxazid , tranylcypromine , amoxapine , clomipramine , imipramine , nortriptyline and desipramine ) and anxiolytic agents ( diazepam , flurazepam and alprazolam ) . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
218,
233
]
} | {
"id": "C0002644",
"name": "amoxapine",
"pos": [
283,
292
]
} |
as of 1989 , the psychotropic drugs that have been reported to inhibit female orgasm include antipsychotic agents ( thioridazine , trifluoperazine and fluphenazine ) , the combination drug perphenazine/amitriptyline , antidepressants ( phenelzine , isocarboxazid , tranylcypromine , amoxapine , clomipramine , imipramine , nortriptyline and desipramine ) and anxiolytic agents ( diazepam , flurazepam and alprazolam ) . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
218,
233
]
} | {
"id": "C0009010",
"name": "clomipramine",
"pos": [
295,
307
]
} |
as of 1989 , the psychotropic drugs that have been reported to inhibit female orgasm include antipsychotic agents ( thioridazine , trifluoperazine and fluphenazine ) , the combination drug perphenazine/amitriptyline , antidepressants ( phenelzine , isocarboxazid , tranylcypromine , amoxapine , clomipramine , imipramine , nortriptyline and desipramine ) and anxiolytic agents ( diazepam , flurazepam and alprazolam ) . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
218,
233
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
310,
320
]
} |
as of 1989 , the psychotropic drugs that have been reported to inhibit female orgasm include antipsychotic agents ( thioridazine , trifluoperazine and fluphenazine ) , the combination drug perphenazine/amitriptyline , antidepressants ( phenelzine , isocarboxazid , tranylcypromine , amoxapine , clomipramine , imipramine , nortriptyline and desipramine ) and anxiolytic agents ( diazepam , flurazepam and alprazolam ) . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
218,
233
]
} | {
"id": "C0028420",
"name": "nortriptyline",
"pos": [
323,
336
]
} |
as of 1989 , the psychotropic drugs that have been reported to inhibit female orgasm include antipsychotic agents ( thioridazine , trifluoperazine and fluphenazine ) , the combination drug perphenazine/amitriptyline , antidepressants ( phenelzine , isocarboxazid , tranylcypromine , amoxapine , clomipramine , imipramine , nortriptyline and desipramine ) and anxiolytic agents ( diazepam , flurazepam and alprazolam ) . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
218,
233
]
} | {
"id": "C0011685",
"name": "desipramine",
"pos": [
341,
352
]
} |
we used isolated rat hearts subjected to coronary artery ligation and reperfusion to study the antiarrhythmic activity of 5-hydroxypropafenone ( 5ohp ) and n-depropylpropafenone ( ndpp ) , major metabolites of propafenone ( p ) in humans , and of the two enantiomers ( r ) - and ( s ) -propafenone . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
95,
109
]
} | {
"id": "C0033429",
"name": "propafenone",
"pos": [
286,
297
]
} |
effect of aliphatic side-chain substituents on the antimalarial activity and on the metabolism of primaquine studied using mitochondria and microsome preparations . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial",
"pos": [
51,
63
]
} | {
"id": "C0033126",
"name": "primaquine",
"pos": [
98,
108
]
} |
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