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the antidepressant efficacy of moclobemide ( 300-600 mg/d ; n = 164 ) was found to be superior to that of placebo ( n = 162 ) and comparable to that of imipramine ( 100-200 mg/d ; n = 164 ) in a 6-w. , double-blind , multicentre study , in patients suffering from a major depressive episode ( dsm-iii ) . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
4,
18
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
152,
162
]
} |
the antidepressant efficacy of moclobemide was compared to that of imipramine , desipramine , clomipramine and amitriptyline . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
4,
18
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
67,
77
]
} |
the antidepressant efficacy of moclobemide was compared to that of imipramine , desipramine , clomipramine and amitriptyline . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
4,
18
]
} | {
"id": "C0011685",
"name": "desipramine",
"pos": [
80,
91
]
} |
the antidepressant efficacy of moclobemide was compared to that of imipramine , desipramine , clomipramine and amitriptyline . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
4,
18
]
} | {
"id": "C0009010",
"name": "clomipramine",
"pos": [
94,
106
]
} |
the antidepressant efficacy of moclobemide was compared to that of imipramine , desipramine , clomipramine and amitriptyline . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
4,
18
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
111,
124
]
} |
the antidepressant efficacy of moclobemide ( 300-600 mg/d ; n = 189 ) was found to be comparable to that of imipramine ( 100-200 mg/d ; n = 192 ) in a 4-w. , double-blind , multicentre study , in patients suffering from a major depressive episode . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
4,
18
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
108,
118
]
} |
antibacterial activity of liposome-entrapped ampicillin in vitro and in vivo in relation to the lipid composition . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
0,
13
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
45,
55
]
} |
the antibacterial activity of liposome-entrapped ampicillin against listeria monocytogenes was investigated in relation to the lipid composition of the liposomes . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
49,
59
]
} |
in vitro antibacterial activities of 9 antibiotics including aztreonam ( azt ) against clinically isolated gram-negative bacteria were determined using mic-2000 plus system . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
9,
22
]
} | {
"id": "C0004521",
"name": "aztreonam",
"pos": [
61,
70
]
} |
azt showed excellent antibacterial activities against escherichia coli , klebsiella pneumoniae , proteus sp . and haemophilus influenzae , and mic80 values of azt against these organisms were lower than 0.20 microgram/ml . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
21,
34
]
} | {
"id": "C0004521",
"name": "azt",
"pos": [
159,
162
]
} |
antibacterial activities of azt were superior to cephem antibiotics compared against enterobacter aerogenes , enterobacter cloacae , citrobacter freundii and serratia marcescens . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
0,
13
]
} | {
"id": "C0004521",
"name": "azt",
"pos": [
28,
31
]
} |
the sensitivity of five antimicrobials ( penicillin , cefoxitin , tetracycline , ceftazidime and spectinomycin ) was assayed in 75 neisseria gonorrhoeae strains , isolated from may 1986 to december 1987 in a general hospital in barcelona . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobials",
"pos": [
24,
38
]
} | {
"id": "C0039644",
"name": "tetracycline",
"pos": [
66,
78
]
} |
[ in vitro antibacterial effect of a new oral cephalosporin , cefixime . results of a multicenter study ] . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
11,
24
]
} | {
"id": "C0060400",
"name": "cefixime",
"pos": [
62,
70
]
} |
the antibacterial activity of fluoroquinolones ( ciprofloxacin and ofloxacin ) combined with beta lactams ( ceftazidime and imipenem ) or aminoglycosides ( tobramycin and amikacin ) against 22 p. aeruginosa isolated from the sputum of patients with cystic fibrosis was determined by the checkerboard method and compared with the combination of beta lactams ( with ticarcillin ) with aminoglycosides . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0007559",
"name": "ceftazidime",
"pos": [
108,
119
]
} |
the antibacterial activity of fluoroquinolones ( ciprofloxacin and ofloxacin ) combined with beta lactams ( ceftazidime and imipenem ) or aminoglycosides ( tobramycin and amikacin ) against 22 p. aeruginosa isolated from the sputum of patients with cystic fibrosis was determined by the checkerboard method and compared with the combination of beta lactams ( with ticarcillin ) with aminoglycosides . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0020933",
"name": "imipenem",
"pos": [
124,
132
]
} |
the antibacterial activity of fluoroquinolones ( ciprofloxacin and ofloxacin ) combined with beta lactams ( ceftazidime and imipenem ) or aminoglycosides ( tobramycin and amikacin ) against 22 p. aeruginosa isolated from the sputum of patients with cystic fibrosis was determined by the checkerboard method and compared with the combination of beta lactams ( with ticarcillin ) with aminoglycosides . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0040341",
"name": "tobramycin",
"pos": [
156,
166
]
} |
the antibacterial activity of fluoroquinolones ( ciprofloxacin and ofloxacin ) combined with beta lactams ( ceftazidime and imipenem ) or aminoglycosides ( tobramycin and amikacin ) against 22 p. aeruginosa isolated from the sputum of patients with cystic fibrosis was determined by the checkerboard method and compared with the combination of beta lactams ( with ticarcillin ) with aminoglycosides . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0002499",
"name": "amikacin",
"pos": [
171,
179
]
} |
the antibacterial activity of fluoroquinolones ( ciprofloxacin and ofloxacin ) combined with beta lactams ( ceftazidime and imipenem ) or aminoglycosides ( tobramycin and amikacin ) against 22 p. aeruginosa isolated from the sputum of patients with cystic fibrosis was determined by the checkerboard method and compared with the combination of beta lactams ( with ticarcillin ) with aminoglycosides . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0040193",
"name": "ticarcillin",
"pos": [
364,
375
]
} |
they compared the ability of these and other antimicrobial agents ciprofloxacin , amikacin and erythromycin alone or in combinations to inhibit the growth of strains of the m. avium complex and of m. xenopi . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial agents",
"pos": [
45,
65
]
} | {
"id": "C0008809",
"name": "ciprofloxacin",
"pos": [
66,
79
]
} |
they compared the ability of these and other antimicrobial agents ciprofloxacin , amikacin and erythromycin alone or in combinations to inhibit the growth of strains of the m. avium complex and of m. xenopi . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial agents",
"pos": [
45,
65
]
} | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
95,
107
]
} |
minimal bactericidal activities ( mbcs ) of three antiseptics ( povidone iodine , chlorhexidine digluconate , benzalkonium chloride ) and one disinfectant ( sodium hypochloride ) where determined , on 580 hospital gram negative bacilli . | therapeutic_class_of | {
"id": "C0003205",
"name": "antiseptics",
"pos": [
50,
61
]
} | {
"id": "C0032857",
"name": "povidone iodine",
"pos": [
64,
79
]
} |
[ quantitative study of the antibacterial effect of cefotaxime and ceftriaxone during experimental escherichia coli k1 bacteremia in chickens ] . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
28,
41
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
52,
62
]
} |
[ quantitative study of the antibacterial effect of cefotaxime and ceftriaxone during experimental escherichia coli k1 bacteremia in chickens ] . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
28,
41
]
} | {
"id": "C0007561",
"name": "ceftriaxone",
"pos": [
67,
78
]
} |
in order to assess the in vivo antibacterial activity of two cephalosporins of third generation , cefotaxime and ceftriaxone , we used the model of experimental bacteremia in chickens we had developed for a few years . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
31,
44
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
98,
108
]
} |
in order to assess the in vivo antibacterial activity of two cephalosporins of third generation , cefotaxime and ceftriaxone , we used the model of experimental bacteremia in chickens we had developed for a few years . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
31,
44
]
} | {
"id": "C0007561",
"name": "ceftriaxone",
"pos": [
113,
124
]
} |
the authors compared the in vitro antifungal activity of itraconazole to that of miconazole against various species of candida . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
34,
44
]
} | {
"id": "C0025942",
"name": "miconazole",
"pos": [
81,
91
]
} |
treatment comprised catheter removal preceded by antifungal drugs ( flucytosine and/or amphotericin b ) in four patients and catheter removal alone in two . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal drugs",
"pos": [
49,
65
]
} | {
"id": "C0016278",
"name": "flucytosine",
"pos": [
68,
79
]
} |
treatment comprised catheter removal preceded by antifungal drugs ( flucytosine and/or amphotericin b ) in four patients and catheter removal alone in two . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal drugs",
"pos": [
49,
65
]
} | {
"id": "C0002679",
"name": "amphotericin b",
"pos": [
87,
101
]
} |
patients treated with cbz show an important reduction of neurological secondary effects related to neuroleptics ( haloperidol ) . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
99,
111
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
114,
125
]
} |
the antibacterial efficacies of daptomycin and vancomycin were compared in male fischer rats with subcutaneous abscesses caused by either methicillin-susceptible staphylococcus aureus ( mssa ) or methicillin-resistant s. aureus ( mrsa ) . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0057144",
"name": "daptomycin",
"pos": [
32,
42
]
} |
the antibacterial efficacies of daptomycin and vancomycin were compared in male fischer rats with subcutaneous abscesses caused by either methicillin-susceptible staphylococcus aureus ( mssa ) or methicillin-resistant s. aureus ( mrsa ) . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0042313",
"name": "vancomycin",
"pos": [
47,
57
]
} |
we examined the effects of chronic treatment with antidepressants ( imipramine or desipramine ) or benzodiazepines ( diazepam , alprazolam , or adinazolam ) on modulation of corticotropin-releasing-factor ( crf ) receptors in discrete areas of rat brain and in anterior pituitary . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
50,
65
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
68,
78
]
} |
we examined the effects of chronic treatment with antidepressants ( imipramine or desipramine ) or benzodiazepines ( diazepam , alprazolam , or adinazolam ) on modulation of corticotropin-releasing-factor ( crf ) receptors in discrete areas of rat brain and in anterior pituitary . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
50,
65
]
} | {
"id": "C0011685",
"name": "desipramine",
"pos": [
82,
93
]
} |
although there was a trend toward increased crf binding in brain stem , striatum , cerebellum , hypothalamus , and frontal cerebral cortex following antidepressant treatment , the changes were only statistically significant in brain stem in imipramine-treated rats . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
149,
163
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
241,
251
]
} |
we reported a ten-year-old autistic girl who had developed neuroleptic malignant syndrome ( nms ) caused by administration of neuroleptic agents , haloperidol and chlorpromazine , because of her behavioral disorders . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic agents",
"pos": [
126,
144
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
147,
158
]
} |
concentration dependent dual effect of the monolauryl ester of sucrose on the antifungal activity and absorption spectra of amphotericin b ( fungizone ) . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
78,
88
]
} | {
"id": "C0002679",
"name": "amphotericin b",
"pos": [
124,
138
]
} |
therefore , ls had concentration-dependent dual effects on the antifungal activity of amb which correlated with shifts in the physical states of amb . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
63,
73
]
} | {
"id": "C0002679",
"name": "amb",
"pos": [
145,
148
]
} |
the concentration range of ls required to inhibit the antifungal effects of amb was about 1000-fold greater than the previously reported concentrations required to inhibit amb toxicity to mammalian cells ( gruda , i. , gauthier , e. , elberg , s. , brajtburg , j. and medoff , g. ( 1988 ) biochem . biophys . res . commun . 154 , 954-958 ) . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
54,
64
]
} | {
"id": "C0002679",
"name": "amb",
"pos": [
172,
175
]
} |
the cardiovascular profile of sc-36602 , a new class 1a/1b antiarrhythmic agent , was compared to those of disopyramide , lidocaine , mexiletine , flecainide , encainide , lorcainide , and quinidine . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agent",
"pos": [
59,
79
]
} | {
"id": "C0012702",
"name": "disopyramide",
"pos": [
107,
119
]
} |
the cardiovascular profile of sc-36602 , a new class 1a/1b antiarrhythmic agent , was compared to those of disopyramide , lidocaine , mexiletine , flecainide , encainide , lorcainide , and quinidine . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agent",
"pos": [
59,
79
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
122,
131
]
} |
the cardiovascular profile of sc-36602 , a new class 1a/1b antiarrhythmic agent , was compared to those of disopyramide , lidocaine , mexiletine , flecainide , encainide , lorcainide , and quinidine . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agent",
"pos": [
59,
79
]
} | {
"id": "C0025887",
"name": "mexiletine",
"pos": [
134,
144
]
} |
the cardiovascular profile of sc-36602 , a new class 1a/1b antiarrhythmic agent , was compared to those of disopyramide , lidocaine , mexiletine , flecainide , encainide , lorcainide , and quinidine . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agent",
"pos": [
59,
79
]
} | {
"id": "C0016229",
"name": "flecainide",
"pos": [
147,
157
]
} |
the cardiovascular profile of sc-36602 , a new class 1a/1b antiarrhythmic agent , was compared to those of disopyramide , lidocaine , mexiletine , flecainide , encainide , lorcainide , and quinidine . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agent",
"pos": [
59,
79
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
189,
198
]
} |
class iii antiarrhythmic action linked with positive inotropy : effects of the d- and l-isomer of sotalol on isolated rat atria at threshold and suprathreshold stimulation . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
10,
24
]
} | {
"id": "C0037707",
"name": "sotalol",
"pos": [
98,
105
]
} |
the effect of timegadine , a novel experimental antirheumatic drug , on human neutrophil ( pmn ) 5-lipoxygenase activity and leukotriene b4 ( ltb4 ) chemotaxis was compared with that of two second-line antiinflammatory drugs , d-penicillamine and levamisole . | therapeutic_class_of | {
"id": "C0003191",
"name": "antirheumatic drug",
"pos": [
48,
66
]
} | {
"id": "C0030817",
"name": "penicillamine",
"pos": [
229,
242
]
} |
further study is called for to elucidate the interaction of neuroleptics such as haloperidol with the vitamin a acids such as isotretinoin . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
60,
72
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
81,
92
]
} |
in this article , we will illustrate the three stages of investigation of receptor interactions and discuss the relevance and importance of the findings , using as examples three drugs known in psychopharmacological research : ( a ) the neuroleptic haloperidol , a prototype of a dopamine d2 antagonist : ( b ) setoperone , a potential antipsychotic agent with very potent serotonin s2 and moderate d2 antagonistic activity ( ceulemans et al . 1985 ; leysen et al . 1986 ) ; | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
237,
248
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
249,
260
]
} |
a trial was devised to assess whether the administration of selenium and cobalt together with the anthelmintic mebendazole ( ovitelmin s & c ) was safe and could improve the supplies of selenium and cobalt for adult sheep fed a whole grain diet , low in both elements , which produced a steady decrease in blood glutathione peroxidase ( gshpx ) and plasma vitamin b12 concentrations . | therapeutic_class_of | {
"id": "C0003158",
"name": "anthelmintic",
"pos": [
98,
110
]
} | {
"id": "C0025023",
"name": "mebendazole",
"pos": [
111,
122
]
} |
neuroleptics ( chlorpromazine , triftazin , haloperidol ) inhibited the tubulin polymerization on supernatant of rat brain proteins in vivo at concentrations which corresponded to the therapeutic ones . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
0,
12
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
44,
55
]
} |
the antiarrhythmic effects of flecainide acetate were evaluated in 9 patients with paroxysmal atrioventricular ( av ) nodal tachycardia and 17 patients with av tachycardia . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
4,
18
]
} | {
"id": "C0086303",
"name": "flecainide acetate",
"pos": [
30,
48
]
} |
dsm-iii schizophrenics who had failed to respond to at least three different neuroleptics underwent a prospective , single-blind trial of haloperidol ( mean dosage , 61 +/- 14 mg/d ) for six weeks . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
77,
89
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
138,
149
]
} |
this open study examined the safety of adding a second slow-acting anti-rheumatic drug ( sard ) - d-penicillamine or sodium aurothiomalate - to the therapy of 38 rheumatoid patients already established on sulphasalazine . | therapeutic_class_of | {
"id": "C0003191",
"name": "anti-rheumatic drug",
"pos": [
67,
86
]
} | {
"id": "C0030817",
"name": "penicillamine",
"pos": [
100,
113
]
} |
the antibacterial activity of the recently developed cephems cefixime and cefetamet-pivoxyl was evaluated in 408 gram-positive and gram-negative rods , all isolated recently from clinical specimens , and compared to that of other orally active agents such as ampicillin , amoxycillin + clavulanic acid , cefaclor , cefuroxime-axetil and to ceftriaxone . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0060400",
"name": "cefixime",
"pos": [
61,
69
]
} |
the antibacterial activity of the recently developed cephems cefixime and cefetamet-pivoxyl was evaluated in 408 gram-positive and gram-negative rods , all isolated recently from clinical specimens , and compared to that of other orally active agents such as ampicillin , amoxycillin + clavulanic acid , cefaclor , cefuroxime-axetil and to ceftriaxone . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
259,
269
]
} |
the antibacterial activity of the recently developed cephems cefixime and cefetamet-pivoxyl was evaluated in 408 gram-positive and gram-negative rods , all isolated recently from clinical specimens , and compared to that of other orally active agents such as ampicillin , amoxycillin + clavulanic acid , cefaclor , cefuroxime-axetil and to ceftriaxone . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0007537",
"name": "cefaclor",
"pos": [
304,
312
]
} |
the antibacterial activity of the recently developed cephems cefixime and cefetamet-pivoxyl was evaluated in 408 gram-positive and gram-negative rods , all isolated recently from clinical specimens , and compared to that of other orally active agents such as ampicillin , amoxycillin + clavulanic acid , cefaclor , cefuroxime-axetil and to ceftriaxone . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0055015",
"name": "cefuroxime-axetil",
"pos": [
315,
332
]
} |
the antibacterial activity of the recently developed cephems cefixime and cefetamet-pivoxyl was evaluated in 408 gram-positive and gram-negative rods , all isolated recently from clinical specimens , and compared to that of other orally active agents such as ampicillin , amoxycillin + clavulanic acid , cefaclor , cefuroxime-axetil and to ceftriaxone . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0007561",
"name": "ceftriaxone",
"pos": [
340,
351
]
} |
sulbactam/ampicillin is a combination of a beta-lactamase inhibitor with minimal intrinsic antibacterial activity ( sulbactam sodium ) , and an aminopenicillin ( ampicillin sodium ) . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
91,
104
]
} | {
"id": "C0282052",
"name": "ampicillin sodium",
"pos": [
162,
179
]
} |
evaluation of 15 clinical , hemodynamic and electrophysiologic variables by stepwise logistic regression identified two independent predictors of successful response to oral antiarrhythmic drugs : 1 ) noninducibility of ventricular tachycardia after intravenous procainamide ( p less than 0.001 ) , and 2 ) left ventricular ejection fraction greater than or equal to 40 % ( p less than 0.05 ) . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drugs",
"pos": [
174,
194
]
} | {
"id": "C0033216",
"name": "procainamide",
"pos": [
262,
274
]
} |
the antiepileptic drugs phenytoin , carbamazepine and valproic acid were demonstrated to limit sustained high frequency repetitive firing of action potentials at free serum concentrations that are achieved in patients being treated for epilepsy . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drugs",
"pos": [
4,
23
]
} | {
"id": "C0031507",
"name": "phenytoin",
"pos": [
24,
33
]
} |
the antiepileptic drugs phenytoin , carbamazepine and valproic acid were demonstrated to limit sustained high frequency repetitive firing of action potentials at free serum concentrations that are achieved in patients being treated for epilepsy . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drugs",
"pos": [
4,
23
]
} | {
"id": "C0042291",
"name": "valproic acid",
"pos": [
54,
67
]
} |
block of single cardiac na+ channels by antiarrhythmic drugs : the effect of amiodarone , propafenone and diprafenone . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drugs",
"pos": [
40,
60
]
} | {
"id": "C0002598",
"name": "amiodarone",
"pos": [
77,
87
]
} |
block of single cardiac na+ channels by antiarrhythmic drugs : the effect of amiodarone , propafenone and diprafenone . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drugs",
"pos": [
40,
60
]
} | {
"id": "C0033429",
"name": "propafenone",
"pos": [
90,
101
]
} |
centbutindole is a new neuroleptic drug having a pharmacological profile similar to haloperidol , but it does not cause hypothermia and has a higher separation between doses causing catalepsy and neurolepsy . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic drug",
"pos": [
23,
39
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
84,
95
]
} |
the acute success was similar for doxycycline with the other antibacterials and was superior to cefaclor . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterials",
"pos": [
61,
75
]
} | {
"id": "C0007537",
"name": "cefaclor",
"pos": [
96,
104
]
} |
in the present investigation , the impact of three antimicrobial agents -- clindamycin , doxycycline and erythromycin -- on the colonisation resistance in the intestinal human microflora was examined . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial agents",
"pos": [
51,
71
]
} | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
105,
117
]
} |
based on its broad antibacterial activity and its high concentration in fetal blood and amniotic fluid , ceftizoxime appears to be an ideal agent for treatment of the intrauterine environment . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
19,
32
]
} | {
"id": "C0007560",
"name": "ceftizoxime",
"pos": [
105,
116
]
} |
it allows colonic decompression and on-table bowel preparation by irrigation with antiseptics such as povidone-iodine ( betadine ) . | therapeutic_class_of | {
"id": "C0003205",
"name": "antiseptics",
"pos": [
82,
93
]
} | {
"id": "C0032857",
"name": "povidone-iodine",
"pos": [
102,
117
]
} |
frequency- and time-dependent depression of ventricular distal conduction by two novel antiarrhythmic drugs , cibenzoline and flecainide . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drugs",
"pos": [
87,
107
]
} | {
"id": "C0016229",
"name": "flecainide",
"pos": [
126,
136
]
} |
the effects of two novel antiarrhythmic drugs , cibenzoline and flecainide , known to exert potent inhibitory effects on sodium channel , were investigated on intraventricular conduction in anaesthetized , closed-chest dogs . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
25,
39
]
} | {
"id": "C0016229",
"name": "flecainide",
"pos": [
64,
74
]
} |
chronic blockade of the dopamine ( da ) d2 receptor by repeated systemic administration of the butyrophenone neuroleptic , haloperidol ( hal ) , is known to lead to a decrease in levels of the neuroactive peptide , substance p ( sp ) , in the rat striatum and substantia nigra ( sn ) . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
109,
120
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
123,
134
]
} |
recovery without complications was accomplished after puncturing , systemic antihelminthic therapy using mebendazole and , finally , total removal of the cyst . | therapeutic_class_of | {
"id": "C0003158",
"name": "antihelminthic",
"pos": [
76,
90
]
} | {
"id": "C0025023",
"name": "mebendazole",
"pos": [
105,
116
]
} |
because candida esophagitis is so frequently the cause of odynophagia and/or dysphagia in aids , it is suggested that in most cases , a therapeutic trial with an antifungal agent , like ketoconazole , may be appropriate before radiologic or endoscopic examination . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal agent",
"pos": [
162,
178
]
} | {
"id": "C0022625",
"name": "ketoconazole",
"pos": [
186,
198
]
} |
additionally , both lactoferrin and transferrin increased the antibacterial effect of a subinhibitory concentration of rifampin , a drug excluded by the bacterial outer membrane . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
62,
75
]
} | {
"id": "C0035608",
"name": "rifampin",
"pos": [
119,
127
]
} |
the reversal of the antibacterial activity of trimethoprim against different species of gram-positive cocci ( staphylococcus aureus , staph . epidermidis , staph . saprophyticus , group b streptococci , streptococcus faecalis and str . faecium ) by thymine , thymidine and various 'folates ' ( folate , folinate , dihydrofolate and tetrahydrofolate ) was tested . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
20,
33
]
} | {
"id": "C0041041",
"name": "trimethoprim",
"pos": [
46,
58
]
} |
since ttx blocks the fast sodium current specifically , this finding suggests that the antiarrhythmic effect of ethmozine and mexiletine in the late stage of myocardial infarction is due to the inhibition of the fast inward sodium current . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
87,
101
]
} | {
"id": "C0025887",
"name": "mexiletine",
"pos": [
126,
136
]
} |
between 1977 and 1979 , a combined antiarrhythmic therapy with quinidine and verapamil was used to treat 66 patients ( aged 16 to 69 years ) with chronic atrial arrhythmias of different etiology . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
35,
49
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
63,
72
]
} |
the metabolite has antidepressant activity of its own , probably associated with its monoamine uptake inhibitory properties , and doubtless makes an important contribution to the efficacy of treatment of depression with clomipramine ; | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
19,
33
]
} | {
"id": "C0009010",
"name": "clomipramine",
"pos": [
220,
232
]
} |
injection of the neuroleptic , pimozide ( 1.0 mg/kg ) before conditioning and again before testing disrupted this conditioned defensive burying ; | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
17,
28
]
} | {
"id": "C0031935",
"name": "pimozide",
"pos": [
31,
39
]
} |
they also suggest that a balance between noradrenergic and serotonergic mechanisms is necessary to improve antidepressant treatment with amitriptyline . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
107,
121
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
137,
150
]
} |
the influence of intraperitoneal administration of two neuroleptic drugs , haloperidol and pimozide ( 2.5 and 5.0 mg/kg ) on pentobarbital induced narcosis , hypothermia and lethality were investigated in mice and rats . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
55,
66
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
75,
86
]
} |
the influence of intraperitoneal administration of two neuroleptic drugs , haloperidol and pimozide ( 2.5 and 5.0 mg/kg ) on pentobarbital induced narcosis , hypothermia and lethality were investigated in mice and rats . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
55,
66
]
} | {
"id": "C0031935",
"name": "pimozide",
"pos": [
91,
99
]
} |
all patients received as antibacterial treatment a 1 : 3 nitrofurantoin/sulphadiazine compound preparation ( urospasmon cum phenazopyridino ) , with a daily dose of 150 mg nitrofurantoin + 450 mg sulphadiazin . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
25,
38
]
} | {
"id": "C0028156",
"name": "nitrofurantoin",
"pos": [
172,
186
]
} |
all patients were on antiepileptic drugs ( sodium valproate , clonazepam and phenobarbital ) , but no evidence was found in vitro that these drugs would have any direct effect on the uptake . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drugs",
"pos": [
21,
40
]
} | {
"id": "C0037567",
"name": "sodium valproate",
"pos": [
43,
59
]
} |
the patient , who had a cellular immunity deficiency , died during antifungal treatment with amphotericin b of the disseminated histoplasmosis is rare : 1 case in 5000 american histoplasmosis cases . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
67,
77
]
} | {
"id": "C0002679",
"name": "amphotericin b",
"pos": [
93,
107
]
} |
drug resistance of 186 e. coli strains isolated in 1977-1978 from patients and carriers , as well as from the environment was studied with respect to 8 widely used antimicrobial drugs , i.e . tetracycline , streptomycin , chloramphenicol , ampicillin , neomycin , kanamycin , nalidixic acid and sulfanilamides . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial drugs",
"pos": [
164,
183
]
} | {
"id": "C0039644",
"name": "tetracycline",
"pos": [
192,
204
]
} |
the antiarrhythmic efficacy and pharmacokinetics of tocainide , an oral analog of lidocaine , was evaluated in 18 hospitalized convalescing myocardial infarction patients . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
4,
18
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
82,
91
]
} |
the effects of the antiarrhythmics quinidine , propranolol , procainamide and lidocaine were determined on the specific binding of [ 3h ] clonidine to the alpha 2-adrenergic receptor . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmics",
"pos": [
19,
34
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
35,
44
]
} |
the effects of the antiarrhythmics quinidine , propranolol , procainamide and lidocaine were determined on the specific binding of [ 3h ] clonidine to the alpha 2-adrenergic receptor . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmics",
"pos": [
19,
34
]
} | {
"id": "C0033216",
"name": "procainamide",
"pos": [
61,
73
]
} |
the effects of the antiarrhythmics quinidine , propranolol , procainamide and lidocaine were determined on the specific binding of [ 3h ] clonidine to the alpha 2-adrenergic receptor . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmics",
"pos": [
19,
34
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
78,
87
]
} |
this led to a longer lasting antibacterial effect and reduction to a lower total count with amoxycillin . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
29,
42
]
} | {
"id": "C0002645",
"name": "amoxycillin",
"pos": [
92,
103
]
} |
acute acetaminophen intoxication in the cat was studied to characterize the antidotal profile of acetylcysteine . | therapeutic_class_of | {
"id": "C0003295",
"name": "antidotal",
"pos": [
76,
85
]
} | {
"id": "C0001047",
"name": "acetylcysteine",
"pos": [
97,
111
]
} |
five of the cats were given antidotal treatment with acetylcysteine ( 140 mg/kg , per os ) at the time of the second dosing with acetaminophen and at 8-hour intervals thereafter for a total of three treatments . | therapeutic_class_of | {
"id": "C0003295",
"name": "antidotal",
"pos": [
28,
37
]
} | {
"id": "C0001047",
"name": "acetylcysteine",
"pos": [
53,
67
]
} |
antibacterial activity of sisomicin was superior to that of gentamicin , amikacin , cefazolin and ampicillin against s. aureus and ps . aeruginosa . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
0,
13
]
} | {
"id": "C0002499",
"name": "amikacin",
"pos": [
73,
81
]
} |
antibacterial activity of sisomicin was superior to that of gentamicin , amikacin , cefazolin and ampicillin against s. aureus and ps . aeruginosa . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
0,
13
]
} | {
"id": "C0007546",
"name": "cefazolin",
"pos": [
84,
93
]
} |
antibacterial activity of sisomicin was superior to that of gentamicin , amikacin , cefazolin and ampicillin against s. aureus and ps . aeruginosa . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
0,
13
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
98,
108
]
} |
the antimicrobial drugs used were : neomycin , neomycin plus oxytetracycline , neomycin plus polymyxin , and sulfadiazine plus trimethoprim . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial drugs",
"pos": [
4,
23
]
} | {
"id": "C0030092",
"name": "oxytetracycline",
"pos": [
61,
76
]
} |
a comparative study on the antiarrhythmic activity and acute toxicity of quinidine and four new analogs in mice . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
27,
41
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
73,
82
]
} |
we have compared the ed50 value for antiarrhythmic activity and the acute toxicities in mice of quinidine and 4 recently synthesized analogs . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
36,
50
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
96,
105
]
} |
the results suggest that the 6'-acetyloxy and 6'-benzoyloxy derivatives may have much greater antiarrhythmic effectiveness than quinidine . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
94,
108
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
128,
137
]
} |
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