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a comparative analysis of the effect from using the antiepileptic drugs tegretol , morpholep , sucsilep , trimethin , chlonazepam , and sodium valproate in 258 patients with trigeminal neuralgia was carried out . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drugs",
"pos": [
52,
71
]
} | {
"id": "C0037567",
"name": "sodium valproate",
"pos": [
136,
152
]
} |
twenty-six hereford or angus bulls of breeding age were used to determine whether the anthelmintic albendazole influenced weights of reproductive organs , spermatozoal production , spermatozoal output , quality of freshly ejaculated or frozen semen , serum testosterone values , or libido . | therapeutic_class_of | {
"id": "C0003158",
"name": "anthelmintic",
"pos": [
86,
98
]
} | {
"id": "C0001911",
"name": "albendazole",
"pos": [
99,
110
]
} |
the in vitro antibacterial activity of amoxicillin combined with clavulanic acid was determined on selected ampicillin-resistant clinical isolates . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
13,
26
]
} | {
"id": "C0002645",
"name": "amoxicillin",
"pos": [
39,
50
]
} |
the in vitro antibacterial activity of amoxicillin combined with clavulanic acid was determined on selected ampicillin-resistant clinical isolates . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
13,
26
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
108,
118
]
} |
synergistic antibacterial effects of mixtures of ampicillin and cloxacillin and induced penicillinases were investigated in 48 strains of proteus . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
12,
25
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
49,
59
]
} |
the antibacterial activity of teicoplanin and vancomycin against 231 clinical isolates of staphylococci and enterococci was evaluated by standardized agar dilution testing . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0042313",
"name": "vancomycin",
"pos": [
46,
56
]
} |
specific binding of [ 3h ] imipramine to its recognition sites in frontal cortex and levels of serotonin ( 5-ht ) , 5-hydroxyindoleacetic acid ( 5-hiaa ) and norepinephrine ( ne ) as well as uptake of serotonin by crude synaptosomal ( p2 ) fraction were determined in a group of rats chronically ( for 21 days ) treated with different types of antidepressant drugs : nortriptyline , fluoxetine , iprindole , phenelzine ( 10 mg/kg per day ) , maprotiline ( 20 mg/kg per day ) and vehicle only ( controls ) . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
344,
358
]
} | {
"id": "C0028420",
"name": "nortriptyline",
"pos": [
367,
380
]
} |
chronic treatment with all antidepressant drugs except iprindole significantly decreased the affinity but not the proportion of high-affinity sites for imipramine . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
27,
41
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
152,
162
]
} |
various antidepressant drugs ( imipramine , mianserin , citalopram , ( + ) oxaprotiline ) and ( - ) oxaprotiline in combination with nifedipine facilitated its effect . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant drugs",
"pos": [
8,
28
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
31,
41
]
} |
conventional and investigational antiarrhythmic agents ( nine patients received amiodarone ) failed to eliminate incessant ventricular tachycardia in all . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agents",
"pos": [
33,
54
]
} | {
"id": "C0002598",
"name": "amiodarone",
"pos": [
80,
90
]
} |
this double-blind , randomized , placebo crossover study was used to evaluate the effects of a cholinesterase inhibitor -- slow-release pyridostigmine ( 180 mg orally every 12 hours ) -- on the anticholinergic and antiarrhythmic properties of disopyramide . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
214,
228
]
} | {
"id": "C0012702",
"name": "disopyramide",
"pos": [
243,
255
]
} |
the effects of the antianginal and antiarrhythmic drug amiodarone on mitochondrial function and high-energy phosphate content were assessed during normothermic ischaemic cardiac arrest and reperfusion in langendorff-perfused rat heart . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drug",
"pos": [
35,
54
]
} | {
"id": "C0002598",
"name": "amiodarone",
"pos": [
55,
65
]
} |
in addition , statistically significant increases occurred in the proportion of organisms resistant to only one antimicrobial ( from 4 % to 9 % ) , the rate of resistance of salmonella typhimurium ( from 14 % to 26 % ) , and the rate of resistance to tetracycline . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial",
"pos": [
112,
125
]
} | {
"id": "C0039644",
"name": "tetracycline",
"pos": [
251,
263
]
} |
of the 200 to 300 compounds synthesised since the first synthetic antimalarial , primaquine in 1926 , 15 to 20 are currently used for malaria treatment , most of which are quinoline derivatives . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial",
"pos": [
66,
78
]
} | {
"id": "C0033126",
"name": "primaquine",
"pos": [
81,
91
]
} |
the antibacterial spectrum to all species of the proteus isolates from hospitalized patients was measured against the most common antibiotics ( amikacin , cefamandole , cefoxitin , ceftriaxone , cephalothin , kanamycin , nalidixic acid , oxolinic acid , pipemidic acid , piromidic acid , tobramycin ) . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0002499",
"name": "amikacin",
"pos": [
144,
152
]
} |
the antibacterial spectrum to all species of the proteus isolates from hospitalized patients was measured against the most common antibiotics ( amikacin , cefamandole , cefoxitin , ceftriaxone , cephalothin , kanamycin , nalidixic acid , oxolinic acid , pipemidic acid , piromidic acid , tobramycin ) . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0007557",
"name": "cefoxitin",
"pos": [
169,
178
]
} |
the antibacterial spectrum to all species of the proteus isolates from hospitalized patients was measured against the most common antibiotics ( amikacin , cefamandole , cefoxitin , ceftriaxone , cephalothin , kanamycin , nalidixic acid , oxolinic acid , pipemidic acid , piromidic acid , tobramycin ) . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0007561",
"name": "ceftriaxone",
"pos": [
181,
192
]
} |
the antibacterial spectrum to all species of the proteus isolates from hospitalized patients was measured against the most common antibiotics ( amikacin , cefamandole , cefoxitin , ceftriaxone , cephalothin , kanamycin , nalidixic acid , oxolinic acid , pipemidic acid , piromidic acid , tobramycin ) . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0022487",
"name": "kanamycin",
"pos": [
209,
218
]
} |
the antibacterial spectrum to all species of the proteus isolates from hospitalized patients was measured against the most common antibiotics ( amikacin , cefamandole , cefoxitin , ceftriaxone , cephalothin , kanamycin , nalidixic acid , oxolinic acid , pipemidic acid , piromidic acid , tobramycin ) . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0040341",
"name": "tobramycin",
"pos": [
288,
298
]
} |
the enhancing effect of apomorphine ( 1.5 micrograms ) and ( +/- ) -3-ppp ( 3 micrograms ) was prevented by neuroleptics , such as haloperidol ( 20 micrograms/kg , i.v . ) and sulpiride ( 2 mg/kg , i.v . ) at doses which , per se , did not affect the spindle . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
108,
120
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
131,
142
]
} |
the electrophysiologic effects of the new antiarrhythmic agent , propafenone , were investigated in 10 mongrel canine neonates , ages 5 to 11 days . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agent",
"pos": [
42,
62
]
} | {
"id": "C0033429",
"name": "propafenone",
"pos": [
65,
76
]
} |
four different neuroleptic drugs , haloperidol , metoclopramide , sulpiride and cis-flupenthixol , were tested for their ability to attenuate an operant lever-pressing response with water as reward and the corresponding consummatory act , i.e. , the non-conditioned water intake . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic drugs",
"pos": [
15,
32
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
35,
46
]
} |
the present report describes that the reversal by antidepressants ( imipramine , desipramine , and nomifensine ) of depressive-like behavior in rats ( escape deficits produced by previous exposure to uncontrollable stress ) was significantly hastened in animals given daily triiodothyronine ( t3 ) . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
50,
65
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
68,
78
]
} |
the present report describes that the reversal by antidepressants ( imipramine , desipramine , and nomifensine ) of depressive-like behavior in rats ( escape deficits produced by previous exposure to uncontrollable stress ) was significantly hastened in animals given daily triiodothyronine ( t3 ) . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
50,
65
]
} | {
"id": "C0011685",
"name": "desipramine",
"pos": [
81,
92
]
} |
because it is known that dopamine can inhibit the tsh response to trh and that some patients with bpd show improvement with antipsychotic ( dopamine-blocking ) medication , we investigated whether haloperidol could reverse the blunted tsh response in bpd . | therapeutic_class_of | {
"id": "C0040615",
"name": "antipsychotic",
"pos": [
124,
137
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
197,
208
]
} |
some clinical reports on antimanic , antidepressant and prophylactic effects of carbamazepine ( cbz ) in manic-depressive illness have appeared since its initial use as an anticonvulsant drug . | therapeutic_class_of | {
"id": "C0242911",
"name": "antimanic",
"pos": [
25,
34
]
} | {
"id": "C0006949",
"name": "carbamazepine",
"pos": [
80,
93
]
} |
some clinical reports on antimanic , antidepressant and prophylactic effects of carbamazepine ( cbz ) in manic-depressive illness have appeared since its initial use as an anticonvulsant drug . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
37,
51
]
} | {
"id": "C0006949",
"name": "carbamazepine",
"pos": [
80,
93
]
} |
however , some antidepressants ( amitriptyline and zimelidine ) potentiated the ergometrine response , while other antidepressants ( desipramine , mianserin and clorgyline ) attenuated this response . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
15,
30
]
} | {
"id": "C0011685",
"name": "desipramine",
"pos": [
133,
144
]
} |
similarly , the down-regulation of s-2 receptors to antidepressant ( amitriptyline ) treatment in mice is constant over the lifespan . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
52,
66
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
69,
82
]
} |
the effect of the addition of 50 % human or mouse serum on the antibacterial activity of cefonicid , three first generation cephalosporins and ampicillin was studied . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
63,
76
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
143,
153
]
} |
therefore susceptibility testing is suggested if antimicrobial therapy with erythromycin is considered to be indicated . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial",
"pos": [
49,
62
]
} | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
76,
88
]
} |
the hemodynamic and antiarrhythmic interactions between nadolol and a commonly used class i antiarrhythmic agent , quinidine or procainamide , were evaluated in 18 patients with ventricular arrhythmias in a double-blind , parallel study . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
20,
34
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
115,
124
]
} |
the hemodynamic and antiarrhythmic interactions between nadolol and a commonly used class i antiarrhythmic agent , quinidine or procainamide , were evaluated in 18 patients with ventricular arrhythmias in a double-blind , parallel study . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
20,
34
]
} | {
"id": "C0033216",
"name": "procainamide",
"pos": [
128,
140
]
} |
af is likely to return despite aggressive antiarrhythmic therapy with amiodarone , a drug with potentially serious side effects . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
42,
56
]
} | {
"id": "C0002598",
"name": "amiodarone",
"pos": [
70,
80
]
} |
indecainide , a new type ic antiarrhythmic agent , and quinidine sulfate were compared in a randomized double-blind parallel study . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agent",
"pos": [
28,
48
]
} | {
"id": "C0034415",
"name": "quinidine sulfate",
"pos": [
55,
72
]
} |
cgp 31608 showed an antibacterial spectrum similar to those of imipenem and sch 34343 ( except that the latter is not active against p. aeruginosa ) but was generally less potent than these drugs . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
20,
33
]
} | {
"id": "C0020933",
"name": "imipenem",
"pos": [
63,
71
]
} |
the antimicrobial therapy of systemic salmonella infections is presently limited to ampicillin , chloramphenicol , and sulfamethoxazole and trimethoprim . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial",
"pos": [
4,
17
]
} | {
"id": "C0038689",
"name": "sulfamethoxazole",
"pos": [
119,
135
]
} |
the type i antiarrhythmic drugs quinidine and n-propylajmaline bitartrate ( npa ) , at high concentrations , also induce a rise in portal pressure and act as a cholestatic agent . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drugs",
"pos": [
11,
31
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
32,
41
]
} |
this clinical trial of a new antidepressant , fluoxetine , shows it to be as effective as a standard tricyclic drug , imipramine . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
29,
43
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
118,
128
]
} |
antibacterial effect of imipenem in vitro against important aerobic and anaerobic strains isolated from clinical specimens . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
0,
13
]
} | {
"id": "C0020933",
"name": "imipenem",
"pos": [
24,
32
]
} |
several of the newer antiarrhythmics are structurally related not only to each other but also to older agents such as lidocaine . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmics",
"pos": [
21,
36
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
118,
127
]
} |
following short term treatments with the neuroleptic drugs haloperidol , chlorpromazine and oxypertine , there was an increase in the sensitivity of rats to the hyperthermic effects of d-amphetamine . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
41,
52
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
59,
70
]
} |
interestingly , the anti-malarial compounds chloroquine and quinacrine also significantly inhibit both accumulation and incorporation of [ 14c ] leucine by b. pahangi . | therapeutic_class_of | {
"id": "C0003374",
"name": "anti-malarial",
"pos": [
20,
33
]
} | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
44,
55
]
} |
liquid sources have included a number of different classes of antiseptics and disinfectants such as quaternary ammonium chlorides , biguanides , hexachlorophene , and iodophors . | therapeutic_class_of | {
"id": "C0003205",
"name": "antiseptics",
"pos": [
62,
73
]
} | {
"id": "C0019435",
"name": "hexachlorophene",
"pos": [
145,
160
]
} |
since the antiarrhythmic effect of chronically administered amiodarone has been thought to be dependent on a depression of thyroid function , we studied the peripheral hormonal pattern of 10 euthyroid patients with ventricular arrhythmias who had been responsive to the acute intravenous administration of the drug ( 10 mg/kg ) . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
10,
24
]
} | {
"id": "C0002598",
"name": "amiodarone",
"pos": [
60,
70
]
} |
therefore the antiarrhythmic effect of amiodarone when acutely administered has no correlation with thyroid hormone serum changes . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
14,
28
]
} | {
"id": "C0002598",
"name": "amiodarone",
"pos": [
39,
49
]
} |
the antiepileptic agent trimethadione was given orally to 13 dogs at a dose of 1.0-1.5 g daily . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic agent",
"pos": [
4,
23
]
} | {
"id": "C0041038",
"name": "trimethadione",
"pos": [
24,
37
]
} |
as in experimental observations , neither a 'pure ' antiarrhythmic agent like lidocaine , nor a betablocking agent like propranolol , prevented acute ischaemic ventricular arrhythmias . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agent",
"pos": [
52,
72
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
78,
87
]
} |
differential effects of antidepressant drugs on [ 3h ] dihydroalprenolol and [ 3h ] imipramine ligand recognition sites in olfactory bulbectomized and sham-lesioned rats . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
24,
38
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
84,
94
]
} |
the i.p . administration of the antidepressants amitriptyline , mianserin , tranylcypromine ( all at a dose of 10 mg/kg ) or iprindole ( 25 mg/kg ) for 28 days followed by a 5-day drug washout period , alters brain part [ 3h ] imipramine and [ 3h ] dihydroalprenolol binding in a manner that is a function of the particular drug , brain part and lesion effect . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
32,
47
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
48,
61
]
} |
the i.p . administration of the antidepressants amitriptyline , mianserin , tranylcypromine ( all at a dose of 10 mg/kg ) or iprindole ( 25 mg/kg ) for 28 days followed by a 5-day drug washout period , alters brain part [ 3h ] imipramine and [ 3h ] dihydroalprenolol binding in a manner that is a function of the particular drug , brain part and lesion effect . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
32,
47
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
227,
237
]
} |
these favourable properties , together with its good antibacterial activity , suggest that cefoperazone will be effective in treating bacterial infections in human beings . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
53,
66
]
} | {
"id": "C0007552",
"name": "cefoperazone",
"pos": [
91,
103
]
} |
we have examined the association of the antimalarial and antirheumatic drug chloroquine ( cq ) to isolated human blood cells . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial",
"pos": [
40,
52
]
} | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
76,
87
]
} |
to determine if myocardial accumulation of desethylamiodarone ( dea ) , its main metabolite , influences its antiarrhythmic activity , three groups of six wistar rats were given amiodarone , 50 mg/kg/day i.p . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
109,
123
]
} | {
"id": "C0002598",
"name": "amiodarone",
"pos": [
178,
188
]
} |
antirheumatic penicillamine and allopurinol used in the treatment of gout also act on oxygen radicals . | therapeutic_class_of | {
"id": "C0003191",
"name": "antirheumatic",
"pos": [
0,
13
]
} | {
"id": "C0030817",
"name": "penicillamine",
"pos": [
14,
27
]
} |
both these effects were mediated by cerebral dopamine receptors , however with different affinity for the neuroleptics haloperidol and sulpiride . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
106,
118
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
119,
130
]
} |
in addition , the neuroleptic haloperidol ( 0.1 mg/kg ) was shown to cause long lasting increases of progesterone levels . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
18,
29
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
30,
41
]
} |
the antifungal agents used were ketoconazole , amphotericin b , 5-fluorocytosine , nystatin , miconazole , bay n 7133 , ici 153,066 , and itraconazole . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal agents",
"pos": [
4,
21
]
} | {
"id": "C0022625",
"name": "ketoconazole",
"pos": [
32,
44
]
} |
the antifungal agents used were ketoconazole , amphotericin b , 5-fluorocytosine , nystatin , miconazole , bay n 7133 , ici 153,066 , and itraconazole . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal agents",
"pos": [
4,
21
]
} | {
"id": "C0002679",
"name": "amphotericin b",
"pos": [
47,
61
]
} |
the antifungal agents used were ketoconazole , amphotericin b , 5-fluorocytosine , nystatin , miconazole , bay n 7133 , ici 153,066 , and itraconazole . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal agents",
"pos": [
4,
21
]
} | {
"id": "C0016278",
"name": "5-fluorocytosine",
"pos": [
64,
80
]
} |
the antifungal agents used were ketoconazole , amphotericin b , 5-fluorocytosine , nystatin , miconazole , bay n 7133 , ici 153,066 , and itraconazole . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal agents",
"pos": [
4,
21
]
} | {
"id": "C0025942",
"name": "miconazole",
"pos": [
94,
104
]
} |
the antidepressant effects of both trazodone and amitriptyline were the same and no correlations between hamilton scores and weight change were found . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
4,
18
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
49,
62
]
} |
blood ethanol concentrations were not influenced by the co-administration of either antidepressant . tmax for trazodone was prolonged by ethanol but the other pharmacokinetic parameters for trazodone and amitriptyline were not influenced by ethanol . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
84,
98
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
204,
217
]
} |
the antiepileptic effect of dpa was observed in 12- and 18-day-old rats , esi specifically inhibited rhythmic activity in adult rats . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic",
"pos": [
4,
17
]
} | {
"id": "C0042291",
"name": "dpa",
"pos": [
28,
31
]
} |
in this study the antidepressant imipramine , the antipsychotics chlorpromazine and haloperidol , and to some extent the anxiolytic buspirone produced qualitatively similar effects - decreased responses and increased reinforcements - although there were some quantitative differences . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
18,
32
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
33,
43
]
} |
in this study the antidepressant imipramine , the antipsychotics chlorpromazine and haloperidol , and to some extent the anxiolytic buspirone produced qualitatively similar effects - decreased responses and increased reinforcements - although there were some quantitative differences . | therapeutic_class_of | {
"id": "C0040615",
"name": "antipsychotics",
"pos": [
50,
64
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
84,
95
]
} |
a differential amine release from mast cells induced by an inhibitory effect of the antidepressant drug amitriptyline on the release of histamine but not on that of serotonin has recently been reported . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
84,
98
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
104,
117
]
} |
the following hemodynamic profile characterizes patients unlikely to have an antiarrhythmic response to moricizine : an increase in ci of less than 1.0 l/min/m2 and no increase in left ventricular stroke work index during supine exercise . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
77,
91
]
} | {
"id": "C0079856",
"name": "moricizine",
"pos": [
104,
114
]
} |
evaluations of the antibacterial activity of amikacin in combination with other antimicrobial agents , principally the beta-lactams , continue to show high rates of enhanced killing or synergy . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
19,
32
]
} | {
"id": "C0002499",
"name": "amikacin",
"pos": [
45,
53
]
} |
the antifungal activity of ketoconazole was studied against fungal pathogens associated with various mycotic infections in animals . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
4,
14
]
} | {
"id": "C0022625",
"name": "ketoconazole",
"pos": [
27,
39
]
} |
antibacterial activity of antibiotics ( azlocillin , tobramycin and piperacillin ) , antiseptics ( metacid , chlorhexidine and quinosoline ) and some other drugs ( dioxidine and mafenide acetate ) against the main representatives of the burn and surgical wound microflora , i. e . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
0,
13
]
} | {
"id": "C0040341",
"name": "tobramycin",
"pos": [
53,
63
]
} |
antibacterial activity of antibiotics ( azlocillin , tobramycin and piperacillin ) , antiseptics ( metacid , chlorhexidine and quinosoline ) and some other drugs ( dioxidine and mafenide acetate ) against the main representatives of the burn and surgical wound microflora , i. e . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
0,
13
]
} | {
"id": "C0031955",
"name": "piperacillin",
"pos": [
68,
80
]
} |
antibacterial activity of antibiotics ( azlocillin , tobramycin and piperacillin ) , antiseptics ( metacid , chlorhexidine and quinosoline ) and some other drugs ( dioxidine and mafenide acetate ) against the main representatives of the burn and surgical wound microflora , i. e . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
0,
13
]
} | {
"id": "C0024453",
"name": "mafenide acetate",
"pos": [
178,
194
]
} |
uk-49,858 , a new antifungal triazole derivative , was compared with amphotericin b in the treatment of pulmonary infections by blastomyces dermatitidis in male balb/cbyj mice . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
18,
28
]
} | {
"id": "C0002679",
"name": "amphotericin",
"pos": [
69,
81
]
} |
influence of human monocytes on the antibacterial activity of kanamycin and gentamicin for staphylococcus aureus . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
36,
49
]
} | {
"id": "C0022487",
"name": "kanamycin",
"pos": [
62,
71
]
} |
the present study was performed to compare the antibacterial activities of kanamycin and gentamicin on staphylococcus aureus phagocytosed by human monocytes and on nonphagocytosed s. aureus . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
47,
60
]
} | {
"id": "C0022487",
"name": "kanamycin",
"pos": [
75,
84
]
} |
selective antimicrobial modulation of the intestinal tract by norfloxacin in human volunteers and in gnotobiotic mice associated with a human fecal flora . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial",
"pos": [
10,
23
]
} | {
"id": "C0028365",
"name": "norfloxacin",
"pos": [
62,
73
]
} |
the kinetics of inhibition of microsomal drug oxidation ( as aminopyrine n-demethylase activity ) by the antimalarial agent primaquine were found to be concentration-dependent . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial agent",
"pos": [
105,
123
]
} | {
"id": "C0033126",
"name": "primaquine",
"pos": [
124,
134
]
} |
the quinoline-containing antimalarial drugs , chloroquine , quinine and mefloquine , inhibit amino acid production at the same concentrations at which they inhibit parasite growth , but have no effect on the endogenous parasite protein degradation . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial drugs",
"pos": [
25,
43
]
} | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
46,
57
]
} |
the quinoline-containing antimalarial drugs , chloroquine , quinine and mefloquine , inhibit amino acid production at the same concentrations at which they inhibit parasite growth , but have no effect on the endogenous parasite protein degradation . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial drugs",
"pos": [
25,
43
]
} | {
"id": "C0025153",
"name": "mefloquine",
"pos": [
72,
82
]
} |
the iodine-containing contrast medium iopanoic acid induces alterations of thyroid hormone metabolism comparable to those observed with the iodine-containing antiarrhythmic drug amiodarone . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drug",
"pos": [
158,
177
]
} | {
"id": "C0002598",
"name": "amiodarone",
"pos": [
178,
188
]
} |
the antiarrhythmic drug , quinidine , and the detergent , tween 80 , also potentiated adr activity in p388r cells to the same extent as ver . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drug",
"pos": [
4,
23
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
26,
35
]
} |
the antibacterial activity of aztreonam , 9 other beta-lactam antibiotics and gentamicin was tested in vitro on 383 recently isolated bacteria . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0004521",
"name": "aztreonam",
"pos": [
30,
39
]
} |
with its beta-lactamase stability , high antibacterial activity and narrow-spectrum aztreonam seems to be a valuable addition to the antibiotic arsenal . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
41,
54
]
} | {
"id": "C0004521",
"name": "aztreonam",
"pos": [
84,
93
]
} |
the efficacy and safety of combined amiodarone and mexiletine treatment was investigated in 16 patients with chronic complex ventricular arrhythmias previously refractory to conventional antiarrhythmic agents and , in a lesser degree , to mexiletine or amiodarone . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agents",
"pos": [
187,
208
]
} | {
"id": "C0025887",
"name": "mexiletine",
"pos": [
239,
249
]
} |
the efficacy and safety of combined amiodarone and mexiletine treatment was investigated in 16 patients with chronic complex ventricular arrhythmias previously refractory to conventional antiarrhythmic agents and , in a lesser degree , to mexiletine or amiodarone . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agents",
"pos": [
187,
208
]
} | {
"id": "C0002598",
"name": "amiodarone",
"pos": [
253,
263
]
} |
data from susceptibility tests of clinical isolates confirmed that cefazolin ( cez ) and cefotiam ( ctm ) showed good antibacterial activity against s. aureus and cefmenoxime ( cmx ) was highly effective on streptococcus spp. , but that the susceptibilities of both organisms to cez , ctm , and cefmetazole ( cmz ) in 1983 were lower than in 1981 . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
118,
131
]
} | {
"id": "C0007546",
"name": "cez",
"pos": [
279,
282
]
} |
although cmx also showed good antibacterial activity against klebsiella spp. , there were no changes in the effectiveness of ctm , cmz , and cez between the years 1981 and 1983 . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
30,
43
]
} | {
"id": "C0007546",
"name": "cez",
"pos": [
141,
144
]
} |
the in vitro antibacterial activities of cmx and cefoperazone against haemophilus spp . were superior to those of the other beta-lactams tested , but there was a decline in the efficacy for cez . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
13,
26
]
} | {
"id": "C0007552",
"name": "cefoperazone",
"pos": [
49,
61
]
} |
the in vitro antibacterial activities of cmx and cefoperazone against haemophilus spp . were superior to those of the other beta-lactams tested , but there was a decline in the efficacy for cez . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
13,
26
]
} | {
"id": "C0007546",
"name": "cez",
"pos": [
190,
193
]
} |
on repeated administration ( 1 mg/kg/day ) for 4 days , the neuroleptic , haloperidol , increased the biosynthesis of me which was more marked than that of lithium administered for the same period ; | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
60,
71
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
74,
85
]
} |
in an attempt to examine the potential aversive properties of the neuroleptic pimozide , a conventional conditioned taste aversion ( cta ) paradigm was employed . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
66,
77
]
} | {
"id": "C0031935",
"name": "pimozide",
"pos": [
78,
86
]
} |
the acute and chronic effects of the antiepileptic drugs clonazepam ( 0.06 , 0.13 , and 0.25 mg/kg ) , phenytoin ( 2.5 , 5 , and 7.5 mg/kg ) , ethosuximide ( 40 , 80 , and 120 mg/kg ) , and valproic acid ( 40 , 80 , and 120 mg/kg ) were evaluated in pigeons responding under a repeated acquisition procedure . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic",
"pos": [
37,
50
]
} | {
"id": "C0031507",
"name": "phenytoin",
"pos": [
103,
112
]
} |
the acute and chronic effects of the antiepileptic drugs clonazepam ( 0.06 , 0.13 , and 0.25 mg/kg ) , phenytoin ( 2.5 , 5 , and 7.5 mg/kg ) , ethosuximide ( 40 , 80 , and 120 mg/kg ) , and valproic acid ( 40 , 80 , and 120 mg/kg ) were evaluated in pigeons responding under a repeated acquisition procedure . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic",
"pos": [
37,
50
]
} | {
"id": "C0015043",
"name": "ethosuximide",
"pos": [
143,
155
]
} |
the acute and chronic effects of the antiepileptic drugs clonazepam ( 0.06 , 0.13 , and 0.25 mg/kg ) , phenytoin ( 2.5 , 5 , and 7.5 mg/kg ) , ethosuximide ( 40 , 80 , and 120 mg/kg ) , and valproic acid ( 40 , 80 , and 120 mg/kg ) were evaluated in pigeons responding under a repeated acquisition procedure . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic",
"pos": [
37,
50
]
} | {
"id": "C0042291",
"name": "valproic acid",
"pos": [
190,
203
]
} |
the rate-frequency functions were examined under administration of two neuroleptics ( pimozide and chlorpromazine ) and three manipulations that interfered with bar pressing ( muscular relaxation with methocarbamol , increased lever weight , and limitation of maximum response rates by an f1 reinforcement schedule ) . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
71,
83
]
} | {
"id": "C0031935",
"name": "pimozide",
"pos": [
86,
94
]
} |
a new antiseptic contrast material , composed of sodium diatrizoate-meglumine diatrizoate and pvp-iodine solutions , was prepared and tested for operative cholangiography . | therapeutic_class_of | {
"id": "C0003205",
"name": "antiseptic",
"pos": [
6,
16
]
} | {
"id": "C0032857",
"name": "pvp-iodine",
"pos": [
94,
104
]
} |
the pharmacokinetics of the antiepileptic drug valproic acid ( 2-propyl-pentanoic acid ; vpa ) and its main active metabolite 2-en-vpa ( 2-propyl-2-pentenoic acid ) in mouse serum and gestational material were studied and correlated with the drastic differences between the two compounds in their embryotoxicity . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drug",
"pos": [
28,
46
]
} | {
"id": "C0042291",
"name": "2-propyl-pentanoic",
"pos": [
63,
81
]
} |
these investigations were repeated during 67 trials of oral antiarrhythmic therapy ( mexiletine 25 , quinidine 24 , metoprolol 13 , disopyramide 2 , procainamide 1 , drug combinations 2 ) . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
60,
74
]
} | {
"id": "C0025887",
"name": "mexiletine",
"pos": [
85,
95
]
} |
these investigations were repeated during 67 trials of oral antiarrhythmic therapy ( mexiletine 25 , quinidine 24 , metoprolol 13 , disopyramide 2 , procainamide 1 , drug combinations 2 ) . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
60,
74
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
101,
110
]
} |
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