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the in vitro antibacterial activity of ampicillin combined with sulbactam 2:1 was evaluated on 257 aerobic gram-positive and gram-negative bacteria , and on 174 anaerobic bacteria from isolated hospital strains by evaluating the minimum inhibitory concentration ( mic ) . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
13,
26
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
39,
49
]
} |
specialists preparing malaria preventive guidelines have , therefore , preferred to recommend the use of relatively safe antimalarial drugs , like chloroquine and proguanil , provided they offer non-immune travellers adequate protection against p. falciparum infections . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial drugs",
"pos": [
121,
139
]
} | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
147,
158
]
} |
specialists preparing malaria preventive guidelines have , therefore , preferred to recommend the use of relatively safe antimalarial drugs , like chloroquine and proguanil , provided they offer non-immune travellers adequate protection against p. falciparum infections . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial drugs",
"pos": [
121,
139
]
} | {
"id": "C0008241",
"name": "proguanil",
"pos": [
163,
172
]
} |
the drug was proved to have excellent antibacterial activities against escherichia coli ( 3 strains ) and group b hemolytic streptococci ( 2 strains ) and these mics were comparable to those of cefotaxime . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
38,
51
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
194,
204
]
} |
intragastric administration of the anti-arrhythmic drugs cm 7857 ( sanofi ) or disopyramide , as expected , significantly reduced the heart rate in normal baboons at rest . | therapeutic_class_of | {
"id": "C0003195",
"name": "anti-arrhythmic",
"pos": [
35,
50
]
} | {
"id": "C0012702",
"name": "disopyramide",
"pos": [
79,
91
]
} |
29 acute schizophrenic patients according to dsm iii and icd-9 underwent examination of performance regarding cognitive and sensorimotor tasks at the beginning and the end of a 28-day neuroleptic treatment with remoxipride or haloperidol in a double-blind design . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
184,
195
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
226,
237
]
} |
we carried out the forced swimming test in mice to investigate the antidepressant potentials of gaba transaminase ( gaba-t ) inhibitors including aminooxyacetic acid , ethanolamine-o-sulfate , gamma-vinyl gaba ( gvg ) and valproic acid ( vpa ) . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
67,
81
]
} | {
"id": "C0042291",
"name": "valproic",
"pos": [
222,
230
]
} |
phenytoin and lamotrigine ( a new antiepileptic drug with an animal experimental profile resembling phenytoin ) have closely similar effects on the quantitative pharmaco-electroencephalogram . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drug",
"pos": [
34,
52
]
} | {
"id": "C0031507",
"name": "phenytoin",
"pos": [
100,
109
]
} |
the antiarrhythmic activity of amiodarone was studied in the model of adrenaline-induced arrhythmia in rats non-dependent and dependent on ethanol . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
4,
18
]
} | {
"id": "C0002598",
"name": "amiodarone",
"pos": [
31,
41
]
} |
after single or repeated joint administration of ethanol and amiodarone the antiarrhythmic effect of amiodarone was attenuated . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
76,
90
]
} | {
"id": "C0002598",
"name": "amiodarone",
"pos": [
101,
111
]
} |
single doses of both the antidepressants did not alter the effect of acute administration of ethanol on eeg , but imipramine and amitriptyline potentiated the ethanol-induced changes in the eeg recorded from the midbrain reticular formation in rabbits receiving ethanol chronically and in the period of abstinene . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
25,
40
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
114,
124
]
} |
single doses of both the antidepressants did not alter the effect of acute administration of ethanol on eeg , but imipramine and amitriptyline potentiated the ethanol-induced changes in the eeg recorded from the midbrain reticular formation in rabbits receiving ethanol chronically and in the period of abstinene . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
25,
40
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
129,
142
]
} |
since severe adverse effects are often observed with amphotericin-b , the most effective antifungal agent , the advent of three new systemic antifungal drugs ( clotrimazole , miconazole , 5-fluorocytosine ) has proven to be a real advance in our therapeutic approach to deep mycoses . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
89,
99
]
} | {
"id": "C0025942",
"name": "miconazole",
"pos": [
175,
185
]
} |
since severe adverse effects are often observed with amphotericin-b , the most effective antifungal agent , the advent of three new systemic antifungal drugs ( clotrimazole , miconazole , 5-fluorocytosine ) has proven to be a real advance in our therapeutic approach to deep mycoses . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
89,
99
]
} | {
"id": "C0016278",
"name": "5-fluorocytosine",
"pos": [
188,
204
]
} |
the effects of i.v . injected antidepressants imipramine ( tofranil , geigy ) and dimetacrine ( istonil , siegfried ) on cardiavascular functions were investigated in 18 patients at diagnostic cardiac catheterization . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
30,
45
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
46,
56
]
} |
in experiments on rats preconvulsive effects were exerted by such neuroleptics as haloperidol unlike apomorphine , possessing opposite properties . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
66,
78
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
82,
93
]
} |
the effect of inoculum size on the antibacterial activity is often small and generally comparable to carbenicillin . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
35,
48
]
} | {
"id": "C0006976",
"name": "carbenicillin",
"pos": [
101,
114
]
} |
antibacterial activity of cefuroxime , a new cephalosporin antibiotic , compared with that of cephaloridine , cephalothin , and cefamandole . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
0,
13
]
} | {
"id": "C0007562",
"name": "cefuroxime",
"pos": [
26,
36
]
} |
this report confirms that sodium pertechnetate tc 99m is the most sensitive agent for diagnostic and therapeutic evaluation of patients with kaposi sarcoma and suggests taht gallium citrate ga 67 or bleomycin 111in may be useful in the differentiation of kaposi sarcoma from lymphoma . | therapeutic_class_of | {
"id": "C0358514",
"name": "agent",
"pos": [
76,
81
]
} | {
"id": "C0893383",
"name": "gallium citrate ga 67",
"pos": [
174,
195
]
} |
the antibacterial spectrum and clinical utility of this agent generally parallels that of ampicillin , but there are minor differences in specificity with regard to individual microorganisms . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
90,
100
]
} |
its less pronounced antibacterial effect , especially against gram-negative pathogens , also becomes evident in the combination with trimethoprim ( tm ) . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
20,
33
]
} | {
"id": "C0041041",
"name": "trimethoprim",
"pos": [
133,
145
]
} |
loperamide , a novel antidiarrheal agent , was compared with diphenoxylate in a double blind crossover study of 23 patients with chronic diarrhea of various etiologies . | therapeutic_class_of | {
"id": "C0003292",
"name": "antidiarrheal agent",
"pos": [
21,
40
]
} | {
"id": "C0012525",
"name": "diphenoxylate",
"pos": [
61,
74
]
} |
antibacterial activity of gentamicin against pseudomonas aeruginosa is very strong , but dibekacin and tobramycin are stronger . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
0,
13
]
} | {
"id": "C0040341",
"name": "tobramycin",
"pos": [
103,
113
]
} |
we describe a sensitive and precise gas-chromatographic method , in which cytosine is used as the internal standard , for determination of an antifungal agent , 5-fluorocytosine , in serum . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
142,
152
]
} | {
"id": "C0016278",
"name": "5-fluorocytosine",
"pos": [
161,
177
]
} |
oral administration of a 1.5-gm dose of n-acetylprocainamide ( napa ) to 9 patients with premature ventricular contractions ( pvcs ) confirmed previous indirect evidence that this metabolite of procainamide has antiarrhythmic efficacy and potency comparable to those of procainamide . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
211,
225
]
} | {
"id": "C0033216",
"name": "procainamide",
"pos": [
270,
282
]
} |
antidepressants-thymoanaleptics chlorimipramine , amitriptyline , imipramine , melitracen potenciated the inhibitory effect of reserpine in a frog ( supression of the turning over from the back reflex ) stronger than did antidepressants with less marked thymoanaleptic action ( lu-5-003 , azaphen , quipazine , desipramine ) and also neuroleptics ( promazine , stelazine , haloperidol ) cholinolytics ( atropine and benectyzine ) and stimulator -- phenamine . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
0,
15
]
} | {
"id": "C0011685",
"name": "desipramine",
"pos": [
311,
322
]
} |
antidepressants-thymoanaleptics chlorimipramine , amitriptyline , imipramine , melitracen potenciated the inhibitory effect of reserpine in a frog ( supression of the turning over from the back reflex ) stronger than did antidepressants with less marked thymoanaleptic action ( lu-5-003 , azaphen , quipazine , desipramine ) and also neuroleptics ( promazine , stelazine , haloperidol ) cholinolytics ( atropine and benectyzine ) and stimulator -- phenamine . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
334,
346
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
373,
384
]
} |
this possibly accounts for the fact that sulpiride , clozapine and thioridazine display an antipsychotic action and yet cause less extrapyramidal side effects than haloperidol and chlorpromazine . | therapeutic_class_of | {
"id": "C0040615",
"name": "antipsychotic",
"pos": [
91,
104
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
164,
175
]
} |
antiseptic detergents , chlorhexidine or povidone iodine show immediate reductions in bacterial counts of 70 % to 80 % , increasing to 99 % after repeated application . | therapeutic_class_of | {
"id": "C0003205",
"name": "antiseptic",
"pos": [
0,
10
]
} | {
"id": "C0032857",
"name": "povidone",
"pos": [
41,
49
]
} |
a mixture of the antiseptic polyvinyl pyrrolidone iodine to the contrast medium , which would prevent a bacterial contamination of the pancreatic duct after erp , is morphologically justifiable but entails a risk of latent hyperthyroidism . | therapeutic_class_of | {
"id": "C0003205",
"name": "antiseptic",
"pos": [
17,
27
]
} | {
"id": "C0032857",
"name": "polyvinyl pyrrolidone iodine",
"pos": [
28,
56
]
} |
the effects of a relatively new antidepressant drug , fluvoxamine , were compared with those produced by chlorimipramine on the 5-hydroxytryptamine system in rat brain . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
32,
46
]
} | {
"id": "C0009010",
"name": "chlorimipramine",
"pos": [
105,
120
]
} |
a new semisynthetic cephalosporin antibiotic designated 7-beta- ( 1-benzylpyridinium-4-yl ) -amino-3- [ ( ( 1-methyl-1h-tetrazol-5-yl ) thio ] methyl ) ceph-3-em-4-carboxylate ( l-640,876 ) was compared for antibacterial activity in vitro with mecillinam , cefoxitin and cefotaxime . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
207,
220
]
} | {
"id": "C0007557",
"name": "cefoxitin",
"pos": [
257,
266
]
} |
a new semisynthetic cephalosporin antibiotic designated 7-beta- ( 1-benzylpyridinium-4-yl ) -amino-3- [ ( ( 1-methyl-1h-tetrazol-5-yl ) thio ] methyl ) ceph-3-em-4-carboxylate ( l-640,876 ) was compared for antibacterial activity in vitro with mecillinam , cefoxitin and cefotaxime . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
207,
220
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
271,
281
]
} |
the authors propose a general design for the clinical evaluation of new antiarrhythmic agents with special reference to their experience with propafenone , a new class 1 agent . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agents",
"pos": [
72,
93
]
} | {
"id": "C0033429",
"name": "propafenone",
"pos": [
142,
153
]
} |
this metabolite accounts for the majority of the antibacterial activity in the bile rifampicin is almost equally excreted in the bile and urine , the recovery in the 2 fluids being of the same order of magnitude . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
49,
62
]
} | {
"id": "C0035608",
"name": "rifampicin",
"pos": [
84,
94
]
} |
although loxapine has tended to be less effective than some standard antipsychotic drugs in a few short-term ( 3 to 4 weeks ) studies , it has been superior to a placebo and about as effective as chlorpromazine , haloperidol , trifluoperazine or thiothixene when evaluated after 4 to 12 weeks . | therapeutic_class_of | {
"id": "C0040615",
"name": "antipsychotic drugs",
"pos": [
69,
88
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
213,
224
]
} |
although loxapine has tended to be less effective than some standard antipsychotic drugs in a few short-term ( 3 to 4 weeks ) studies , it has been superior to a placebo and about as effective as chlorpromazine , haloperidol , trifluoperazine or thiothixene when evaluated after 4 to 12 weeks . | therapeutic_class_of | {
"id": "C0040615",
"name": "antipsychotic drugs",
"pos": [
69,
88
]
} | {
"id": "C0039955",
"name": "thiothixene",
"pos": [
246,
257
]
} |
correlation between serum concentration and pharmacological effect on atrioventricular conduction time of the antiarrhythmic drug propafenone . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
110,
124
]
} | {
"id": "C0033429",
"name": "propafenone",
"pos": [
130,
141
]
} |
seven patients with cardiac dysrhythmias received a single , oral , therapeutically effective dose of the antiarrhythmic drug propafenone . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
106,
120
]
} | {
"id": "C0033429",
"name": "propafenone",
"pos": [
126,
137
]
} |
injection of a combination of three drugs , 5-hydroxytryptophan , the alpha-blocker phentolamine and the neuroleptic drug haloperidol into mice before or together with sheep red blood cells ( srbc ) induces a complete and long-lasting inhibition of antibody production to srbc and leads to specific unresponsiveness . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic drug",
"pos": [
105,
121
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
122,
133
]
} |
the influence of antimicrobial agents on the percentage of tetracycline-resistant bacteria in faeces of humans and animals . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial agents",
"pos": [
17,
37
]
} | {
"id": "C0039644",
"name": "tetracycline",
"pos": [
59,
71
]
} |
a one-year treatment with bromperidol in a group of 30 patients ( schizophrenic ) has given us the impression that the product is a valuable antipsychotic drug which in most cases can successfully be substituted for haloperidol . | therapeutic_class_of | {
"id": "C0040615",
"name": "antipsychotic drug",
"pos": [
141,
159
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
216,
227
]
} |
in 13 patients admitted to a coronary care unit , antiarrhythmic efficacy and safety of quinidine gluconate in a nonmatrix formulation were compared to placebo and quinidine sulfate . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
50,
64
]
} | {
"id": "C0072869",
"name": "quinidine gluconate",
"pos": [
88,
107
]
} |
in 13 patients admitted to a coronary care unit , antiarrhythmic efficacy and safety of quinidine gluconate in a nonmatrix formulation were compared to placebo and quinidine sulfate . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
50,
64
]
} | {
"id": "C0034415",
"name": "quinidine sulfate",
"pos": [
164,
181
]
} |
the methyl ester of amphotericin b ( ame ) is water soluble , retains antifungal activity , and is significantly less toxic in mammals than amphotericin b . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
70,
80
]
} | {
"id": "C0002679",
"name": "amphotericin b",
"pos": [
140,
154
]
} |
results of earlier turbidimetric growth experiments showed that certain antioxidants prolonged the antifungal activity of amphotericin b ( ab ) against candida albicans , presumably by retarding autoxidative destruction of the drug . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
99,
109
]
} | {
"id": "C0002679",
"name": "amphotericin b",
"pos": [
122,
136
]
} |
delayed antifungal activity and serum inhibition may limit the in vivo effectiveness of miconazole in murine cryptococcosis . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
8,
18
]
} | {
"id": "C0025942",
"name": "miconazole",
"pos": [
88,
98
]
} |
the influence of antirheumatic drugs , acetylsalicylic acid , diacetoxibenzoic acid , imurane and d-penicillamine , on the status of immunocompetent cells in experimental infectious-allergic carditis was studied morphologically in 70 rabbits . | therapeutic_class_of | {
"id": "C0003191",
"name": "antirheumatic drugs",
"pos": [
17,
36
]
} | {
"id": "C0030817",
"name": "penicillamine",
"pos": [
100,
113
]
} |
high-performance liquid chromatography has been employed in the development of assay methods for six antiarrhythmic drugs , disopyramide , lidocain , tocainide , procainamide , aprinidine and quinidine . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drugs",
"pos": [
101,
121
]
} | {
"id": "C0012702",
"name": "disopyramide",
"pos": [
124,
136
]
} |
high-performance liquid chromatography has been employed in the development of assay methods for six antiarrhythmic drugs , disopyramide , lidocain , tocainide , procainamide , aprinidine and quinidine . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drugs",
"pos": [
101,
121
]
} | {
"id": "C0023660",
"name": "lidocain",
"pos": [
139,
147
]
} |
high-performance liquid chromatography has been employed in the development of assay methods for six antiarrhythmic drugs , disopyramide , lidocain , tocainide , procainamide , aprinidine and quinidine . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drugs",
"pos": [
101,
121
]
} | {
"id": "C0033216",
"name": "procainamide",
"pos": [
162,
174
]
} |
high-performance liquid chromatography has been employed in the development of assay methods for six antiarrhythmic drugs , disopyramide , lidocain , tocainide , procainamide , aprinidine and quinidine . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drugs",
"pos": [
101,
121
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
192,
201
]
} |
the antibacterial activity of cefamandole against 445 clinical isolates was investigated and compared with the activity of other known cephalosporins ( cephalothin , cephaloridine , cephalexin , and cefazolin ) and of two penicillins ( ampicillin and carbenicillin ) . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
182,
192
]
} |
the antibacterial activity of cefamandole against 445 clinical isolates was investigated and compared with the activity of other known cephalosporins ( cephalothin , cephaloridine , cephalexin , and cefazolin ) and of two penicillins ( ampicillin and carbenicillin ) . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0007546",
"name": "cefazolin",
"pos": [
199,
208
]
} |
the antibacterial activity of cefamandole against 445 clinical isolates was investigated and compared with the activity of other known cephalosporins ( cephalothin , cephaloridine , cephalexin , and cefazolin ) and of two penicillins ( ampicillin and carbenicillin ) . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
236,
246
]
} |
the antibacterial activity of cefamandole against 445 clinical isolates was investigated and compared with the activity of other known cephalosporins ( cephalothin , cephaloridine , cephalexin , and cefazolin ) and of two penicillins ( ampicillin and carbenicillin ) . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0006976",
"name": "carbenicillin",
"pos": [
251,
264
]
} |
[ in vitro antibacterial activity of tobramycin used in combination with cephalothin or carbenicillin ( author 's transl ) ] . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
11,
24
]
} | {
"id": "C0040341",
"name": "tobramycin",
"pos": [
37,
47
]
} |
[ in vitro antibacterial activity of tobramycin used in combination with cephalothin or carbenicillin ( author 's transl ) ] . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
11,
24
]
} | {
"id": "C0006976",
"name": "carbenicillin",
"pos": [
88,
101
]
} |
the antibacterial activities , absorption and excretion of talampicillin hydrochloride were compared with those of amoxicillin and ampicillin . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0002645",
"name": "amoxicillin",
"pos": [
115,
126
]
} |
the antibacterial activities , absorption and excretion of talampicillin hydrochloride were compared with those of amoxicillin and ampicillin . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
131,
141
]
} |
talampicillin hydrochloride showed a broad-spectrum antibacterial activity against gram-positive and gram-negative bacteria as seen in amoxicillin and ampicillin . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
52,
65
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
151,
161
]
} |
meningitis due to candida albicans was successfully treated in a 1.1 kg premature infant using combined antifungal therapy of amphotericin b for three weeks and 5-fluorocytosine for four months . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
104,
114
]
} | {
"id": "C0002679",
"name": "amphotericin b",
"pos": [
126,
140
]
} |
meningitis due to candida albicans was successfully treated in a 1.1 kg premature infant using combined antifungal therapy of amphotericin b for three weeks and 5-fluorocytosine for four months . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
104,
114
]
} | {
"id": "C0016278",
"name": "5-fluorocytosine",
"pos": [
161,
177
]
} |
the antidepressants desipramine and imipramine were compared within the framework of a multiclinical study performed under the conditions of a controlled clinical experiment . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
4,
19
]
} | {
"id": "C0011685",
"name": "desipramine",
"pos": [
20,
31
]
} |
the antidepressants desipramine and imipramine were compared within the framework of a multiclinical study performed under the conditions of a controlled clinical experiment . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
4,
19
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
36,
46
]
} |
besides the antiarrhythmic effect of propafenone the effect on changes of pq- and qrs duration as well as the corresponding serum concentration was measured . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
12,
26
]
} | {
"id": "C0033429",
"name": "propafenone",
"pos": [
37,
48
]
} |
seven structurally-related compounds consisting of three antidepressant drugs ( imipramine , desmethylimipramine and amitriptyline ) , three tranquillizing agents ( promazine , chlorpromazine and chlorprothixene ) and a hybrid , desmethylpromazine , have been examined in a series of tests involving autonomic functions and antagonism of reserpine . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant drugs",
"pos": [
57,
77
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
102,
112
]
} |
seven structurally-related compounds consisting of three antidepressant drugs ( imipramine , desmethylimipramine and amitriptyline ) , three tranquillizing agents ( promazine , chlorpromazine and chlorprothixene ) and a hybrid , desmethylpromazine , have been examined in a series of tests involving autonomic functions and antagonism of reserpine . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant drugs",
"pos": [
57,
77
]
} | {
"id": "C0011685",
"name": "desmethylimipramine",
"pos": [
93,
112
]
} |
seven structurally-related compounds consisting of three antidepressant drugs ( imipramine , desmethylimipramine and amitriptyline ) , three tranquillizing agents ( promazine , chlorpromazine and chlorprothixene ) and a hybrid , desmethylpromazine , have been examined in a series of tests involving autonomic functions and antagonism of reserpine . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant drugs",
"pos": [
57,
77
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
117,
130
]
} |
no evidence has been obtained to indicate that a central parasympatholytic action is an important component of the antidepressant activity of imipramine and related drugs . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
115,
129
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
142,
152
]
} |
the influence of progabide , a new antiepileptic drug , on the pharmacokinetic profiles of phenobarbital , phenytoin , carbamazepine , and valproic acid was evaluated in four separate studies , each including six young healthy volunteers . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drug",
"pos": [
35,
53
]
} | {
"id": "C0031507",
"name": "phenytoin",
"pos": [
107,
116
]
} |
the influence of progabide , a new antiepileptic drug , on the pharmacokinetic profiles of phenobarbital , phenytoin , carbamazepine , and valproic acid was evaluated in four separate studies , each including six young healthy volunteers . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drug",
"pos": [
35,
53
]
} | {
"id": "C0042291",
"name": "valproic acid",
"pos": [
139,
152
]
} |
the new anti-arrhythmic agent , amiodarone , is increasingly recognized as a cause of pulmonary toxicity ( apt ) . | therapeutic_class_of | {
"id": "C0003195",
"name": "anti-arrhythmic agent",
"pos": [
8,
29
]
} | {
"id": "C0002598",
"name": "amiodarone",
"pos": [
32,
42
]
} |
both antimicrobial agents were significantly ( p less than 0.0001 ) more efficacious than placebo in the treatment of diarrhea , with the average duration of diarrhea being 29 , 20 , and 81 hours , respectively , in the ciprofloxacin , trimethoprim-sulfamethoxazole , and placebo treatment groups . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial agents",
"pos": [
5,
25
]
} | {
"id": "C0008809",
"name": "ciprofloxacin",
"pos": [
220,
233
]
} |
chronic treatment with the antidepressant imipramine resulted in a decrease of the 24-hr mean 5-ht binding by about 50 % and a 2-hr delay of peak and trough values . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
27,
41
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
42,
52
]
} |
prenatal exposure to the neuroleptic haloperidol has been reported to produce an enduring decrement in the number of dopamine d2 receptors in rat striatum and a persistent diminution of a dopamine dependent behavior , stereotypy . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
25,
36
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
37,
48
]
} |
anthelmintic efficacies of ivermectin , febantel , fenbendazole , and mebendazole were compared in 45 adult gray foxes ( urocyon cinereoargenteus ) naturally infected with helminth parasites . | therapeutic_class_of | {
"id": "C0003158",
"name": "anthelmintic",
"pos": [
0,
12
]
} | {
"id": "C0025023",
"name": "mebendazole",
"pos": [
70,
81
]
} |
the test , designed to detect potential novel antirheumatic agents , was based on a putative mode of action for d-penicillamine . | therapeutic_class_of | {
"id": "C0003191",
"name": "antirheumatic agents",
"pos": [
46,
66
]
} | {
"id": "C0030817",
"name": "penicillamine",
"pos": [
114,
127
]
} |
for c. curticei , statistically significant antiparasitic activity was evident in animals five and ten days after treatment with ivermectin given by injection and five days after treatment with ivermectin given orally . | therapeutic_class_of | {
"id": "C0003404",
"name": "antiparasitic",
"pos": [
44,
57
]
} | {
"id": "C0022322",
"name": "ivermectin",
"pos": [
194,
204
]
} |
these data suggest that chronic treatment with three antidepressants produces dopamine autoreceptor subsensitivity in nigrostriatal neurons more than mesolimbic neurons and that this effect is not seen with short-term imipramine treatment . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
53,
68
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
218,
228
]
} |
selective toxicity of the antimalarial primaquine-evidence for both uncoupling and inhibitory effects of a metabolite on the energetics of mitochondria and its atp synthase complex . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial",
"pos": [
26,
38
]
} | {
"id": "C0033126",
"name": "primaquine",
"pos": [
39,
49
]
} |
lysates inhibited antibacterial activity of penicillin g , dicloxacillin , tetracycline , and minocycline to about the same extent as did human plasma . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
18,
31
]
} | {
"id": "C0030827",
"name": "penicillin g",
"pos": [
44,
56
]
} |
lysates inhibited antibacterial activity of penicillin g , dicloxacillin , tetracycline , and minocycline to about the same extent as did human plasma . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
18,
31
]
} | {
"id": "C0012093",
"name": "dicloxacillin",
"pos": [
59,
72
]
} |
among the neuroleptics haloperidol alone depressed the uptake of serotonin in the concentration of 10 ( -5 ) m . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
10,
22
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
23,
34
]
} |
the in vitro antifungal activities of six compounds possessing the quinolizidine skeleton , including all the newly synthesized compounds as well as some previously reported ones , and amphotericin b were tested against several human pathogenic fungi . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
13,
23
]
} | {
"id": "C0002679",
"name": "amphotericin b",
"pos": [
185,
199
]
} |
about 30 patients with , in some cases , recurring paranoid or paranoid-hallucinatory psychoses underwent a long-term treatment -- from 2 -- 6 years according to individual cases -- with very small doses of powerful neuroleptics ( haloperidol , triperidol , and occasionally trisedyl ) . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
216,
228
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
231,
242
]
} |
the authors report an experimental study on the ocular toxicity of some antibiotics ( ampicillin , gentamicin , cephalotin sodic , tobramycin ) and some antifungals ( amphotericin b , flucytosin ) . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungals",
"pos": [
153,
164
]
} | {
"id": "C0002679",
"name": "amphotericin b",
"pos": [
167,
181
]
} |
five inhibitors of the gaba degrading enzyme gaba-aminotransferase ( gaba-t ) , viz. , gabaculine , gamma-acetylenic gaba , gamma-vinyl gaba , ethanolamine o-sulphate , and aminooxyacetic acid , as well as gaba itself and the antiepileptic sodium valproate were administered to mice in doses equieffective to raise the electroconvulsive threshold by 30 v . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic",
"pos": [
226,
239
]
} | {
"id": "C0037567",
"name": "sodium valproate",
"pos": [
240,
256
]
} |
lidocaine is widely used in antiarrhythmic therapy , and the need to monitor the drug concentration in the blood of patients receiving lidocaine is well established . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
28,
42
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
135,
144
]
} |
the electrophysiological effects of the new antiarrhythmic drug flecainide ( r 818 ) was tested in altogether 27 patients with and without disturbances of sinus node function and intraventricular conduction . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
44,
58
]
} | {
"id": "C0016229",
"name": "flecainide",
"pos": [
64,
74
]
} |
two schedules of anthelmintic oral treatment , using mebendazole powder , were compared in 73 dogs naturally infected with common helminth intestinal parasites . | therapeutic_class_of | {
"id": "C0003158",
"name": "anthelmintic",
"pos": [
17,
29
]
} | {
"id": "C0025023",
"name": "mebendazole",
"pos": [
53,
64
]
} |
the recent development of new antifungal antimicrobials that can be administered in combination with amphotericin b or as alternatives to it has expanded the dimensions of treatment for fungal infections of the central nervous system . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
30,
40
]
} | {
"id": "C0002679",
"name": "amphotericin b",
"pos": [
101,
115
]
} |
in terms of antibacterial spectrum and intrinsic activity , ceftazidime is an improvement upon existing beta-lactam antibiotics in clinical use and can be regarded as a possible alternative to gentamicin . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
12,
25
]
} | {
"id": "C0007559",
"name": "ceftazidime",
"pos": [
60,
71
]
} |
treatment groups received one of the following anthelmintics : mebendazole , febantel , febantel plus trichlorphon , morantel tartrate , or a combination of thiabendazole , piperazine and trichlorphon . | therapeutic_class_of | {
"id": "C0003158",
"name": "anthelmintics",
"pos": [
47,
60
]
} | {
"id": "C0025023",
"name": "mebendazole",
"pos": [
63,
74
]
} |
on day zero , each treatment group received one of the following anthelmintics : thiabendazole , cambendazole , mebendazole , oxibendazole , piperazine , thiabendazole/piperazine , cambendazole/piperazine , mebendazole/piperazine or oxibendazole/piperazine . | therapeutic_class_of | {
"id": "C0003158",
"name": "anthelmintics",
"pos": [
65,
78
]
} | {
"id": "C0025023",
"name": "mebendazole",
"pos": [
207,
218
]
} |
1 the minimal dose which significantly potentiates the hyperthermia induced by thyrotrophin releasing hormone ( trh , 40 mg/kg i.p . ) in mice has been established for tricyclic and other antidepressants ( imipramine , amitriptyline , clomipramine , nortriptyline , maprotiline , nomifensine , viloxazine ) including a specific inhibitor of noradrenaline ( na ) uptake ( nisoxetine ) . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
188,
203
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
206,
216
]
} |
1 the minimal dose which significantly potentiates the hyperthermia induced by thyrotrophin releasing hormone ( trh , 40 mg/kg i.p . ) in mice has been established for tricyclic and other antidepressants ( imipramine , amitriptyline , clomipramine , nortriptyline , maprotiline , nomifensine , viloxazine ) including a specific inhibitor of noradrenaline ( na ) uptake ( nisoxetine ) . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
188,
203
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
219,
232
]
} |
1 the minimal dose which significantly potentiates the hyperthermia induced by thyrotrophin releasing hormone ( trh , 40 mg/kg i.p . ) in mice has been established for tricyclic and other antidepressants ( imipramine , amitriptyline , clomipramine , nortriptyline , maprotiline , nomifensine , viloxazine ) including a specific inhibitor of noradrenaline ( na ) uptake ( nisoxetine ) . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
188,
203
]
} | {
"id": "C0009010",
"name": "clomipramine",
"pos": [
235,
247
]
} |
1 the minimal dose which significantly potentiates the hyperthermia induced by thyrotrophin releasing hormone ( trh , 40 mg/kg i.p . ) in mice has been established for tricyclic and other antidepressants ( imipramine , amitriptyline , clomipramine , nortriptyline , maprotiline , nomifensine , viloxazine ) including a specific inhibitor of noradrenaline ( na ) uptake ( nisoxetine ) . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
188,
203
]
} | {
"id": "C0028420",
"name": "nortriptyline",
"pos": [
250,
263
]
} |
variable metabolite concentrations and the uncertainty of their relative psychoactivity may contribute to the difficulties in relating antidepressant efficacy to serum concentrations of the administered imi or dmi . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
135,
149
]
} | {
"id": "C0020934",
"name": "imi",
"pos": [
203,
206
]
} |
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