text
stringlengths 57
1.72k
| relation
stringclasses 125
values | h
dict | t
dict |
|---|---|---|---|
we compared the in vitro antifungal action of amphotericin b ( amb ) used alone or in combination with a second polyene antibiotic or with miconazole or ketoconazole . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
25,
35
]
} | {
"id": "C0002679",
"name": "amphotericin b",
"pos": [
46,
60
]
} |
we compared the in vitro antifungal action of amphotericin b ( amb ) used alone or in combination with a second polyene antibiotic or with miconazole or ketoconazole . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
25,
35
]
} | {
"id": "C0025942",
"name": "miconazole",
"pos": [
139,
149
]
} |
we compared the in vitro antifungal action of amphotericin b ( amb ) used alone or in combination with a second polyene antibiotic or with miconazole or ketoconazole . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
25,
35
]
} | {
"id": "C0022625",
"name": "ketoconazole",
"pos": [
153,
165
]
} |
in a preliminary study 2 kinds of antidepressants , amitriptyline ( tricyclic ) and nomifensine ( non-tricyclic ) were administered to 20 healthy volunteers . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
34,
49
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
52,
65
]
} |
[ comparison of the in vitro antifungal activities of clotrimazole , miconazole , econazole and exalamide against clinical isolates of dermatophytes ( author 's transl ) ] . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
29,
39
]
} | {
"id": "C0025942",
"name": "miconazole",
"pos": [
69,
79
]
} |
[ comparison of the in vitro antifungal activities of clotrimazole , miconazole , econazole and exalamide against clinical isolates of dermatophytes ( author 's transl ) ] . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
29,
39
]
} | {
"id": "C0013547",
"name": "econazole",
"pos": [
82,
91
]
} |
[ anti-arrhythmia and antifibrillatory effect of flecainide in programmed ventricle stimulation and in recent heart infarction ] . | therapeutic_class_of | {
"id": "C0003195",
"name": "anti-arrhythmia",
"pos": [
2,
17
]
} | {
"id": "C0016229",
"name": "flecainide",
"pos": [
49,
59
]
} |
we studied the effect of peritoneal dialysis solution ( pds ) on the antibacterial activity of seven cephalosporins , gentamicin , tobramycin and amikacin . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
69,
82
]
} | {
"id": "C0040341",
"name": "tobramycin",
"pos": [
131,
141
]
} |
we studied the effect of peritoneal dialysis solution ( pds ) on the antibacterial activity of seven cephalosporins , gentamicin , tobramycin and amikacin . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
69,
82
]
} | {
"id": "C0002499",
"name": "amikacin",
"pos": [
146,
154
]
} |
a double blind controlled trial involving 37 inpatients whose depression was judged clinically to require antidepressant medication revealed that amoxapine and amitriptyline was approximately equal in efficacy . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant medication",
"pos": [
106,
131
]
} | {
"id": "C0002644",
"name": "amoxapine",
"pos": [
146,
155
]
} |
a double blind controlled trial involving 37 inpatients whose depression was judged clinically to require antidepressant medication revealed that amoxapine and amitriptyline was approximately equal in efficacy . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant medication",
"pos": [
106,
131
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
160,
173
]
} |
the in vitro antibacterial activity of five third-generation cephalosporins ( thienamycin , ceftazidime , cefotaxime , moxalactam and cefoperazone ) was compared with that of three second-generation cephalosporins ( cefoxitin , cefamandole and cefuroxime ) against 313 routine clinical isolates . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
13,
26
]
} | {
"id": "C0007559",
"name": "ceftazidime",
"pos": [
92,
103
]
} |
the in vitro antibacterial activity of five third-generation cephalosporins ( thienamycin , ceftazidime , cefotaxime , moxalactam and cefoperazone ) was compared with that of three second-generation cephalosporins ( cefoxitin , cefamandole and cefuroxime ) against 313 routine clinical isolates . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
13,
26
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
106,
116
]
} |
the in vitro antibacterial activity of five third-generation cephalosporins ( thienamycin , ceftazidime , cefotaxime , moxalactam and cefoperazone ) was compared with that of three second-generation cephalosporins ( cefoxitin , cefamandole and cefuroxime ) against 313 routine clinical isolates . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
13,
26
]
} | {
"id": "C0007552",
"name": "cefoperazone",
"pos": [
134,
146
]
} |
the in vitro antibacterial activity of five third-generation cephalosporins ( thienamycin , ceftazidime , cefotaxime , moxalactam and cefoperazone ) was compared with that of three second-generation cephalosporins ( cefoxitin , cefamandole and cefuroxime ) against 313 routine clinical isolates . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
13,
26
]
} | {
"id": "C0007557",
"name": "cefoxitin",
"pos": [
216,
225
]
} |
the in vitro antibacterial activity of five third-generation cephalosporins ( thienamycin , ceftazidime , cefotaxime , moxalactam and cefoperazone ) was compared with that of three second-generation cephalosporins ( cefoxitin , cefamandole and cefuroxime ) against 313 routine clinical isolates . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
13,
26
]
} | {
"id": "C0007562",
"name": "cefuroxime",
"pos": [
244,
254
]
} |
no single cephalosporin showed overall superiority in antibacterial activity , but thienamycin and ceftazidime were the most active against the range of bacteria tested . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
54,
67
]
} | {
"id": "C0007559",
"name": "ceftazidime",
"pos": [
99,
110
]
} |
this work report a study of antibacterial activity of eight third generation cephalosporins : cefotaxime , moxalactam , cefoperazone , cefotiam , ceftazidime , ceftriaxone , cefmenoxime and cefotetan . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
28,
41
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
94,
104
]
} |
this work report a study of antibacterial activity of eight third generation cephalosporins : cefotaxime , moxalactam , cefoperazone , cefotiam , ceftazidime , ceftriaxone , cefmenoxime and cefotetan . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
28,
41
]
} | {
"id": "C0007552",
"name": "cefoperazone",
"pos": [
120,
132
]
} |
this work report a study of antibacterial activity of eight third generation cephalosporins : cefotaxime , moxalactam , cefoperazone , cefotiam , ceftazidime , ceftriaxone , cefmenoxime and cefotetan . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
28,
41
]
} | {
"id": "C0007559",
"name": "ceftazidime",
"pos": [
146,
157
]
} |
this work report a study of antibacterial activity of eight third generation cephalosporins : cefotaxime , moxalactam , cefoperazone , cefotiam , ceftazidime , ceftriaxone , cefmenoxime and cefotetan . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
28,
41
]
} | {
"id": "C0007561",
"name": "ceftriaxone",
"pos": [
160,
171
]
} |
this work report a study of antibacterial activity of eight third generation cephalosporins : cefotaxime , moxalactam , cefoperazone , cefotiam , ceftazidime , ceftriaxone , cefmenoxime and cefotetan . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
28,
41
]
} | {
"id": "C0007555",
"name": "cefotetan",
"pos": [
190,
199
]
} |
[ antibacterial activity of netilmicin in combination with other antibiotics . comparison with other aminoglycosides ( author 's transl ) ] . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
2,
15
]
} | {
"id": "C0027780",
"name": "netilmicin",
"pos": [
28,
38
]
} |
the charts of 80 outpatients who responded to antidepressants were reviewed to determine if there was a higher rate of premature medication discontinuation with phenelzine than with imipramine . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
46,
61
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
182,
192
]
} |
these antibacterial activities were superior to these of ampicillin and cephalexin , except against s. pyogenes . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
6,
19
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
57,
67
]
} |
these antibacterial activities were superior to these of ampicillin and cephalexin , except against s. pyogenes . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
6,
19
]
} | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
72,
82
]
} |
the antibacterial activity of cefminox ( cmnx ) was compared to those of cefotaxime ( ctx ) and latamoxef ( lmox ) in human urine using 11 clinical isolates from complicated urinary tract infections . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
73,
83
]
} |
the following antiarrhythmic drugs were each given intravenously to eight different dogs : procainamide ( 25 mg/kg ) , lidocaine ( 2 mg/kg + 70 micrograms/kg/min ) , flecainide ( 3 mg/kg ) , timolol ( 0.1 mg/kg ) , clofilium ( 1 mg/kg ) , dl-sotalol ( 5 mg/kg ) , and bethanidine ( 4 mg/kg ) . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drugs",
"pos": [
14,
34
]
} | {
"id": "C0033216",
"name": "procainamide",
"pos": [
91,
103
]
} |
the following antiarrhythmic drugs were each given intravenously to eight different dogs : procainamide ( 25 mg/kg ) , lidocaine ( 2 mg/kg + 70 micrograms/kg/min ) , flecainide ( 3 mg/kg ) , timolol ( 0.1 mg/kg ) , clofilium ( 1 mg/kg ) , dl-sotalol ( 5 mg/kg ) , and bethanidine ( 4 mg/kg ) . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drugs",
"pos": [
14,
34
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
119,
128
]
} |
the following antiarrhythmic drugs were each given intravenously to eight different dogs : procainamide ( 25 mg/kg ) , lidocaine ( 2 mg/kg + 70 micrograms/kg/min ) , flecainide ( 3 mg/kg ) , timolol ( 0.1 mg/kg ) , clofilium ( 1 mg/kg ) , dl-sotalol ( 5 mg/kg ) , and bethanidine ( 4 mg/kg ) . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drugs",
"pos": [
14,
34
]
} | {
"id": "C0016229",
"name": "flecainide",
"pos": [
166,
176
]
} |
the following antiarrhythmic drugs were each given intravenously to eight different dogs : procainamide ( 25 mg/kg ) , lidocaine ( 2 mg/kg + 70 micrograms/kg/min ) , flecainide ( 3 mg/kg ) , timolol ( 0.1 mg/kg ) , clofilium ( 1 mg/kg ) , dl-sotalol ( 5 mg/kg ) , and bethanidine ( 4 mg/kg ) . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drugs",
"pos": [
14,
34
]
} | {
"id": "C0037707",
"name": "sotalol",
"pos": [
242,
249
]
} |
the tricyclic antidepressants trimipramine and doxepin , and the neuroleptic agents trifluoperazine and haloperidol were tested for their effect on histamine h2-receptor-mediated adenylate cyclase activity and h+ secretion in guinea-pig parietal cells . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
65,
76
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
104,
115
]
} |
this survey of lc methods includes the first and second generations , and new antidepressants such as alprazolam , amoxapine , bupropion , maprotiline , trazodone , and selected metabolites . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
78,
93
]
} | {
"id": "C0002644",
"name": "amoxapine",
"pos": [
115,
124
]
} |
pharmacokinetic factors affecting antidepressant drug clearance and clinical effect : evaluation of doxepin and imipramine -- new data and review . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant drug",
"pos": [
34,
53
]
} | {
"id": "C0013085",
"name": "doxepin",
"pos": [
100,
107
]
} |
pharmacokinetic factors affecting antidepressant drug clearance and clinical effect : evaluation of doxepin and imipramine -- new data and review . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant drug",
"pos": [
34,
53
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
112,
122
]
} |
all of the multiply antimicrobial-resistant strains were highly susceptible ( mic less than or equal to 0.25 micrograms/ml ) to the two quinolones ciprofloxacin and pefloxacin . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial",
"pos": [
20,
33
]
} | {
"id": "C0008809",
"name": "ciprofloxacin",
"pos": [
147,
160
]
} |
this article reviews the role of a new depot antipsychotic dosage form , haloperidol decanoate ( hd ) , in relationship to other comparable pharmacotherapies ( oral and injectable ) . | therapeutic_class_of | {
"id": "C0040615",
"name": "antipsychotic",
"pos": [
45,
58
]
} | {
"id": "C0062103",
"name": "haloperidol decanoate",
"pos": [
73,
94
]
} |
a host of new agents with different pharmacokinetic and electrophysiological actions are now available , and can be compared or contrasted to conventional antiarrhythmic agents such as quinidine , procainamide , disopyramide , lignocaine ( lidocaine ) and bretylium . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
155,
169
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
185,
194
]
} |
a host of new agents with different pharmacokinetic and electrophysiological actions are now available , and can be compared or contrasted to conventional antiarrhythmic agents such as quinidine , procainamide , disopyramide , lignocaine ( lidocaine ) and bretylium . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
155,
169
]
} | {
"id": "C0033216",
"name": "procainamide",
"pos": [
197,
209
]
} |
a host of new agents with different pharmacokinetic and electrophysiological actions are now available , and can be compared or contrasted to conventional antiarrhythmic agents such as quinidine , procainamide , disopyramide , lignocaine ( lidocaine ) and bretylium . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
155,
169
]
} | {
"id": "C0012702",
"name": "disopyramide",
"pos": [
212,
224
]
} |
a host of new agents with different pharmacokinetic and electrophysiological actions are now available , and can be compared or contrasted to conventional antiarrhythmic agents such as quinidine , procainamide , disopyramide , lignocaine ( lidocaine ) and bretylium . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
155,
169
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
240,
249
]
} |
the effects of fluconazole , a novel antifungal compound with a bis-triazole structure , were compared with those of ketoconazole on mitogen-induced dna synthesis by cultured mouse lymphocytes , and on the destruction of fungal ( candida albicans ) blastospores by human polymorphonuclear leukocytes . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
37,
47
]
} | {
"id": "C0022625",
"name": "ketoconazole",
"pos": [
117,
129
]
} |
in addition , therefore , to having excellent in vivo antifungal activity , fluconazole , unlike ketoconazole , has been shown to have no inhibitory effect in two in vitro assays of immune function . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
54,
64
]
} | {
"id": "C0022625",
"name": "ketoconazole",
"pos": [
97,
109
]
} |
cinoxacin represents an additional valuable and effective antibacterial in post-coital prophylaxis of recurrent urinary tract infection in otherwise healthy premenopausal women , although it is slightly less effective than cotrimoxazole or nitrofurantoin . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
58,
71
]
} | {
"id": "C0028156",
"name": "nitrofurantoin",
"pos": [
240,
254
]
} |
the antibacterial efficacy of ceftriaxone ( ctrx ) against group b streptococcus and its clinical efficacy in newborns were examined , and the results obtained are summarized as follows . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0007561",
"name": "ceftriaxone",
"pos": [
30,
41
]
} |
the efficiency of various combinations of antiarrhythmic agents ( quinidine , etmozin , disopyramide , mexitil , and allapinine ) was assessed in 24 cases of frequent ventricular and supraventricular extrasystoles , where treatment with one of the above listed drugs had been ineffective . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agents",
"pos": [
42,
63
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
66,
75
]
} |
the efficiency of various combinations of antiarrhythmic agents ( quinidine , etmozin , disopyramide , mexitil , and allapinine ) was assessed in 24 cases of frequent ventricular and supraventricular extrasystoles , where treatment with one of the above listed drugs had been ineffective . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agents",
"pos": [
42,
63
]
} | {
"id": "C0012702",
"name": "disopyramide",
"pos": [
88,
100
]
} |
the histamine induced facilitation was blocked completely by cimetidine and antidepressant drugs-imipramine and desipramine , but remained unaffected in mice pretreated with mepyramine or atropine . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant drugs",
"pos": [
76,
96
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
97,
107
]
} |
the histamine induced facilitation was blocked completely by cimetidine and antidepressant drugs-imipramine and desipramine , but remained unaffected in mice pretreated with mepyramine or atropine . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant drugs",
"pos": [
76,
96
]
} | {
"id": "C0011685",
"name": "desipramine",
"pos": [
112,
123
]
} |
the asexual stages of plasmodium living within the erythrocyte result in growth-related changes in the permeability properties of the red cell for substances such as glucose , amino acids , purine nucleosides , sodium , potassium , calcium , zinc , iron and several antimalarial drugs such as chloroquine , amodiaquine and mefloquine . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial drugs",
"pos": [
266,
284
]
} | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
293,
304
]
} |
the asexual stages of plasmodium living within the erythrocyte result in growth-related changes in the permeability properties of the red cell for substances such as glucose , amino acids , purine nucleosides , sodium , potassium , calcium , zinc , iron and several antimalarial drugs such as chloroquine , amodiaquine and mefloquine . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial drugs",
"pos": [
266,
284
]
} | {
"id": "C0025153",
"name": "mefloquine",
"pos": [
323,
333
]
} |
these findings suggest that the free dph fraction can be predicted from the total concentration , even when the drug is coadministered with other antiepileptic drugs , the sole exception being vpa . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drugs",
"pos": [
146,
165
]
} | {
"id": "C0042291",
"name": "vpa",
"pos": [
193,
196
]
} |
the reported biological half-life of the antiarrhythmic drug procainamide ( pa ) is between 2 and 4 h . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
41,
55
]
} | {
"id": "C0033216",
"name": "procainamide",
"pos": [
61,
73
]
} |
in an open prospective study of postoperative infectious complications , patients undergoing elective colorectal surgery were randomly allocated to one of three groups receiving parenteral single-dose antimicrobial prophylaxis ( 1 g or 3 g metronidazole or 1 g metronidazole + 3 g nalidixic acid ) . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial",
"pos": [
201,
214
]
} | {
"id": "C0025872",
"name": "metronidazole",
"pos": [
261,
274
]
} |
a contact electrode catheter , which permits clinical recording of cardiac monophasic action potentials ( maps ) , was used as a means of quantifying the electrophysiologic effect of 2 antiarrhythmic drugs , procainamide and quinidine . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
185,
199
]
} | {
"id": "C0033216",
"name": "procainamide",
"pos": [
208,
220
]
} |
a contact electrode catheter , which permits clinical recording of cardiac monophasic action potentials ( maps ) , was used as a means of quantifying the electrophysiologic effect of 2 antiarrhythmic drugs , procainamide and quinidine . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
185,
199
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
225,
234
]
} |
the combining site specificities of ige antibodies that react with the oral antibacterial agent trimethoprim and found in the sera of two subjects who experienced anaphylaxis after taking the drug , were investigated . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial agent",
"pos": [
76,
95
]
} | {
"id": "C0041041",
"name": "trimethoprim",
"pos": [
96,
108
]
} |
wr 194,965 phosphate , a new antimalarial agent containing a biphenyl ring structure active against chloroquine-resistant plasmodium falciparum , crystallized in ionic form with a positive charge on the quaternary nitrogen atom . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial agent",
"pos": [
29,
47
]
} | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
100,
111
]
} |
fourteen schizophrenic subjects were evaluated for degree of psychosis before and after treatment with the antipsychotic drug haloperidol and for plasma homovanillic acid concentration after four and 28 days of treatment . | therapeutic_class_of | {
"id": "C0040615",
"name": "antipsychotic drug",
"pos": [
107,
125
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
126,
137
]
} |
organ-specific , qualitative changes in the phospholipid composition of rats after chronic administration of the antidepressant drug desipramine . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
113,
127
]
} | {
"id": "C0011685",
"name": "desipramine",
"pos": [
133,
144
]
} |
the in vitro antibacterial activity of teicoplanin , a new glycopeptide antibiotic , previously named teichomycin a2 , has been compared to that of five other chemoantibiotics : netilmicin , clindamycin , rifampicin , enoxacin and vancomycin . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
13,
26
]
} | {
"id": "C0027780",
"name": "netilmicin",
"pos": [
178,
188
]
} |
the in vitro antibacterial activity of teicoplanin , a new glycopeptide antibiotic , previously named teichomycin a2 , has been compared to that of five other chemoantibiotics : netilmicin , clindamycin , rifampicin , enoxacin and vancomycin . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
13,
26
]
} | {
"id": "C0008947",
"name": "clindamycin",
"pos": [
191,
202
]
} |
the in vitro antibacterial activity of teicoplanin , a new glycopeptide antibiotic , previously named teichomycin a2 , has been compared to that of five other chemoantibiotics : netilmicin , clindamycin , rifampicin , enoxacin and vancomycin . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
13,
26
]
} | {
"id": "C0035608",
"name": "rifampicin",
"pos": [
205,
215
]
} |
the in vitro antibacterial activity of teicoplanin , a new glycopeptide antibiotic , previously named teichomycin a2 , has been compared to that of five other chemoantibiotics : netilmicin , clindamycin , rifampicin , enoxacin and vancomycin . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
13,
26
]
} | {
"id": "C0042313",
"name": "vancomycin",
"pos": [
231,
241
]
} |
the effects of single and chronic doses of rolipram on the sensitivity of alpha 2-adrenoceptors have been compared with the phosphodiesterase inhibitors , isobutylmethylxanthine ( ibmx ) and ici 63,197 , and the antidepressant , desipramine . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
212,
226
]
} | {
"id": "C0011685",
"name": "desipramine",
"pos": [
229,
240
]
} |
on six models of arrhythmias of atrial and ventricular types ( induced by administration of aconitine , chlorcalcium , chlorbarium , strophanthin , chloroform-adrenaline and by coronary occlusion ) it was shown that in rats , cats and rabbits the antiarrhythmic , preventive and relieving activity of brevicarine dichlorhydrate exceeded that of quinidine , novocainamide and lidocaine in power by 3-5 times and in duration by 3-18 times . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
247,
261
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
345,
354
]
} |
on six models of arrhythmias of atrial and ventricular types ( induced by administration of aconitine , chlorcalcium , chlorbarium , strophanthin , chloroform-adrenaline and by coronary occlusion ) it was shown that in rats , cats and rabbits the antiarrhythmic , preventive and relieving activity of brevicarine dichlorhydrate exceeded that of quinidine , novocainamide and lidocaine in power by 3-5 times and in duration by 3-18 times . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
247,
261
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
375,
384
]
} |
the efficiency of a number of antiarrhythmic drugs ( etmozin , quinidine , mexytil , allapinin , cordarone ) , used alone and in combinations , was assessed in 13 patients with refractory continuous extrasystoles of varying origins . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
30,
44
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
63,
72
]
} |
the ability of four antidepressant drugs , imipramine , alaproclate , norzimelidine , and fluvoxamine , to inhibit serotonin transport into platelet plasma membrane vesicles was tested over a range of external na+ concentrations . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant drugs",
"pos": [
20,
40
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
43,
53
]
} |
currently , antiepileptic drugs such as valproic acid , phenytoin , carbamazepine and a few antiarrhythmic drugs meet the theoretical criteria justifying free drug level monitoring . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drugs",
"pos": [
12,
31
]
} | {
"id": "C0042291",
"name": "valproic acid",
"pos": [
40,
53
]
} |
currently , antiepileptic drugs such as valproic acid , phenytoin , carbamazepine and a few antiarrhythmic drugs meet the theoretical criteria justifying free drug level monitoring . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drugs",
"pos": [
12,
31
]
} | {
"id": "C0031507",
"name": "phenytoin",
"pos": [
56,
65
]
} |
a comprehensive method is presented for the determination of nine antidepressant drugs and metabolites in serum : ( 1 ) amitriptyline , ( 2 ) nortriptyline , ( 3 ) imipramine , ( 4 ) desipramine , ( 5 ) maprotiline , ( 6 ) doxepin , ( 7 ) desmethyldoxepin , ( 8 ) protriptyline , and ( 9 ) trimipramine . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
66,
80
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
120,
133
]
} |
a comprehensive method is presented for the determination of nine antidepressant drugs and metabolites in serum : ( 1 ) amitriptyline , ( 2 ) nortriptyline , ( 3 ) imipramine , ( 4 ) desipramine , ( 5 ) maprotiline , ( 6 ) doxepin , ( 7 ) desmethyldoxepin , ( 8 ) protriptyline , and ( 9 ) trimipramine . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
66,
80
]
} | {
"id": "C0028420",
"name": "nortriptyline",
"pos": [
142,
155
]
} |
a comprehensive method is presented for the determination of nine antidepressant drugs and metabolites in serum : ( 1 ) amitriptyline , ( 2 ) nortriptyline , ( 3 ) imipramine , ( 4 ) desipramine , ( 5 ) maprotiline , ( 6 ) doxepin , ( 7 ) desmethyldoxepin , ( 8 ) protriptyline , and ( 9 ) trimipramine . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
66,
80
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
292,
302
]
} |
a comprehensive method is presented for the determination of nine antidepressant drugs and metabolites in serum : ( 1 ) amitriptyline , ( 2 ) nortriptyline , ( 3 ) imipramine , ( 4 ) desipramine , ( 5 ) maprotiline , ( 6 ) doxepin , ( 7 ) desmethyldoxepin , ( 8 ) protriptyline , and ( 9 ) trimipramine . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
66,
80
]
} | {
"id": "C0011685",
"name": "desipramine",
"pos": [
183,
194
]
} |
a comprehensive method is presented for the determination of nine antidepressant drugs and metabolites in serum : ( 1 ) amitriptyline , ( 2 ) nortriptyline , ( 3 ) imipramine , ( 4 ) desipramine , ( 5 ) maprotiline , ( 6 ) doxepin , ( 7 ) desmethyldoxepin , ( 8 ) protriptyline , and ( 9 ) trimipramine . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
66,
80
]
} | {
"id": "C0013085",
"name": "doxepin",
"pos": [
248,
255
]
} |
a comprehensive method is presented for the determination of nine antidepressant drugs and metabolites in serum : ( 1 ) amitriptyline , ( 2 ) nortriptyline , ( 3 ) imipramine , ( 4 ) desipramine , ( 5 ) maprotiline , ( 6 ) doxepin , ( 7 ) desmethyldoxepin , ( 8 ) protriptyline , and ( 9 ) trimipramine . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
66,
80
]
} | {
"id": "C0033743",
"name": "protriptyline",
"pos": [
264,
277
]
} |
a comprehensive method is presented for the determination of nine antidepressant drugs and metabolites in serum : ( 1 ) amitriptyline , ( 2 ) nortriptyline , ( 3 ) imipramine , ( 4 ) desipramine , ( 5 ) maprotiline , ( 6 ) doxepin , ( 7 ) desmethyldoxepin , ( 8 ) protriptyline , and ( 9 ) trimipramine . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
66,
80
]
} | {
"id": "C0041056",
"name": "trimipramine",
"pos": [
290,
302
]
} |
the most active member of the new cephalosporins was 7- ( o-aminomethylphenylacetamido ) -3- ( 6-hydroxypyridazin-3-ylthilmethyl ) -3-cephem- 4-carboxylic acid ( bb-s 150 ) ( 1g ) which has in vitro antibacterial activity superior to cephalothin and cefazolin against both gram-negative and gram-positive organisms . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
199,
212
]
} | {
"id": "C0007546",
"name": "cefazolin",
"pos": [
250,
259
]
} |
the most active member of this series was 7- ( o-aminomethylphenylacetamido ) -3- ( tetrazolo- [ 4,5-b ] pyridazin-6-ylthiomethyl ) -3 -cephem-4-carboxylic acid ( bb-s 226 ) ( 24e ) with antibacterial activity superior activity superior to cephalothin and cefazolin . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
187,
200
]
} | {
"id": "C0007546",
"name": "cefazolin",
"pos": [
256,
265
]
} |
the main emphasis in this paper is on the broad-spectrum antifungal agent amphotericin b and the narrow-spectrum agent flucytosine . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal agent",
"pos": [
57,
73
]
} | {
"id": "C0002679",
"name": "amphotericin b",
"pos": [
74,
88
]
} |
the main emphasis in this paper is on the broad-spectrum antifungal agent amphotericin b and the narrow-spectrum agent flucytosine . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal agent",
"pos": [
57,
73
]
} | {
"id": "C0016278",
"name": "flucytosine",
"pos": [
119,
130
]
} |
( + ) -amphetamine and h 77/77 produced increased grooming which was antagonized by the tyrosine hydroxylase inhibitor h 44/68 ( 250 mg/kg ) , the dopamine-beta-hydroxylase inhibitor fla 63 ( 40 ) , the neuroleptics haloperidol ( 0.1 and 0.5 ) , and clozapine ( 1 and 5 ) . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
203,
215
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
216,
227
]
} |
development of this hyperactivity can be blocked by postoperative treatment with the antidepressant , desmethylimipramine , or by preoperative destruction of norepinephrine terminals with 6-hydroxydopamine . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
85,
99
]
} | {
"id": "C0011685",
"name": "desmethylimipramine",
"pos": [
102,
121
]
} |
tranquilizers ( diazepam , chlordiazepoxide , benatyzine ) , antidepressants ( amytriptiline , imipramine ) and some neuroleptics ( trifluoperazine , haloperidol ) in a low doze prevented these disturbances . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
61,
76
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
95,
105
]
} |
tranquilizers ( diazepam , chlordiazepoxide , benatyzine ) , antidepressants ( amytriptiline , imipramine ) and some neuroleptics ( trifluoperazine , haloperidol ) in a low doze prevented these disturbances . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
117,
129
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
150,
161
]
} |
the effect of a-adrenergic and dopaminergic blockade on the ability of pituitary-hypothalamic axis to produce an lh surge in response to oestrogen , was studied in eleven women treated with the neuroleptic agents haloperidol , fluphenazine or chlorpromazine . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic agents",
"pos": [
194,
212
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
213,
224
]
} |
it was demonstrated that the anthelmintics mebendazole and fenbendazole were significantly less effective in eradicating parasites when animals were deficient in iron and protein . | therapeutic_class_of | {
"id": "C0003158",
"name": "anthelmintics",
"pos": [
29,
42
]
} | {
"id": "C0025023",
"name": "mebendazole",
"pos": [
43,
54
]
} |
[ long-term treatment with the new antiarrhythmic drug propafenone in correlation to plasma levels ( author 's transl ) ] . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
35,
49
]
} | {
"id": "C0033429",
"name": "propafenone",
"pos": [
55,
66
]
} |
we suggest that the clinically most important parameters for monitoring an antiarrhythmic regimen of propafenone are the patients 's own history and ecg-examination noting the pq interval and particularly the width of the qrs-complex and long-term monitoring . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
75,
89
]
} | {
"id": "C0033429",
"name": "propafenone",
"pos": [
101,
112
]
} |
the comparative antiarrhythmic activity of quinidine , propranolol and the combination of these two drugs was studied in experimental atrial and ventricular arrhythmias in the dog . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
16,
30
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
43,
52
]
} |
the effects of the following neuroleptics were investigated : spiroperidol ( 0.2 mg/kg i.p . ) , pimozide ( 1 and 2 mg/kg i.p . ) , and clozapine ( 2 and 5 mg/kg i.p . ) . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
29,
41
]
} | {
"id": "C0031935",
"name": "pimozide",
"pos": [
97,
105
]
} |
a new antidepressant , amoxapine , which is a dibenzoxazepine deprivative , was compared with amitriptyline in a randomised double-blind trial . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
6,
20
]
} | {
"id": "C0002644",
"name": "amoxapine",
"pos": [
23,
32
]
} |
a new antidepressant , amoxapine , which is a dibenzoxazepine deprivative , was compared with amitriptyline in a randomised double-blind trial . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
6,
20
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
94,
107
]
} |
the factors involved in the appearance of this arrhythmia were the administration of antiarrhythmic drugs ( quinidine 22 patients , procainamide 5 patients , ajmaline 1 patient ) , antianginal drugs ( prenylamine [ synadrin ] 4 patients ) and antidepressant drugs ( thioridazine 1 patient ) . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
85,
99
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
108,
117
]
} |
the factors involved in the appearance of this arrhythmia were the administration of antiarrhythmic drugs ( quinidine 22 patients , procainamide 5 patients , ajmaline 1 patient ) , antianginal drugs ( prenylamine [ synadrin ] 4 patients ) and antidepressant drugs ( thioridazine 1 patient ) . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
85,
99
]
} | {
"id": "C0033216",
"name": "procainamide",
"pos": [
132,
144
]
} |
twenty-nine patients with documented myocardial infarction receiving no other antiarrhythmic drugs and having no evidence of congestive heart failure , liver disease or renal failure were randomly assigned to one or two groups : group 1 -- lidocaine infusion was abruptly discontinued after a course of therapy , and group 2 -- lidocaine infusion was tapered over a three-hour period . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drugs",
"pos": [
78,
98
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
328,
337
]
} |
susceptibility tests using 7 antimicrobial agents ( carbenicillin , chloramphenicol , clindamycin , penicillin , cephalothin , metronidazole , and tetracycline ) were run against 35 anaerobes including bacteroides fragilis ( 17 ) , other gram-negative bacilli ( 7 ) , clostridia ( 5 ) , peptococci ( 4 ) , and eubacteria ( 2 ) . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial agents",
"pos": [
29,
49
]
} | {
"id": "C0025872",
"name": "metronidazole",
"pos": [
127,
140
]
} |
susceptibility tests using 7 antimicrobial agents ( carbenicillin , chloramphenicol , clindamycin , penicillin , cephalothin , metronidazole , and tetracycline ) were run against 35 anaerobes including bacteroides fragilis ( 17 ) , other gram-negative bacilli ( 7 ) , clostridia ( 5 ) , peptococci ( 4 ) , and eubacteria ( 2 ) . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial agents",
"pos": [
29,
49
]
} | {
"id": "C0039644",
"name": "tetracycline",
"pos": [
147,
159
]
} |
tioconazole ( uk-20,349 ) , a new antifungal imidazole derivative , was compared with miconazole for activity in vitro against candida spp. , torulopsis glabrata , cryptococcus neoformans , aspergillus spp. , and dermatophyte fungi ( trichophyton spp . and microsporum spp . ) . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
34,
44
]
} | {
"id": "C0025942",
"name": "miconazole",
"pos": [
86,
96
]
} |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.