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|---|---|---|---|
an in vitro assay was used to determine efficacy and if side resistance was present to benzimidazole anthelmintics tested against caenorhabditis elegans after selection with albendazole . | therapeutic_class_of | {
"id": "C0003158",
"name": "anthelmintics",
"pos": [
101,
114
]
} | {
"id": "C0001911",
"name": "albendazole",
"pos": [
174,
185
]
} |
antiarrhythmic drug testing carried out in the late reperfusion phase with lidocaine ( 1 mg/kg bolus followed by continuous infusion ) revealed 50 % efficacy at a dosage of 40 micrograms/kg/min , 100 % at 80 micrograms/kg/min , and 67 % at 120 mu/kg/min . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drug",
"pos": [
0,
19
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
75,
84
]
} |
in vitro studies revealed a synergistic antibacterial effect of cholic and deoxycholic acid combinations with cefazolin . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
40,
53
]
} | {
"id": "C0007546",
"name": "cefazolin",
"pos": [
110,
119
]
} |
effects of the antidepressant drug desipramine ( dmi ) on fluorescence anisotropy were studied in living cultured human fibroblasts , rat brain astrocytes and rat roc-1 hybridoma cells ( oligodendrocytes x c6 ) . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
15,
29
]
} | {
"id": "C0011685",
"name": "desipramine",
"pos": [
35,
46
]
} |
the studies described herein were designed to test the hypothesis that a neuroleptic , haloperidol , may alter the level of expression of the tyrosine hydroxylase and cholecystokinin genes in discrete brain regions . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
73,
84
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
87,
98
]
} |
the antiarrhythmic drug disopyramide ( dp ) is metabolized to the mono-n-dealkylated compound ( mnd ) and to the pyrrolidone derivative ( pyr ) . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drug",
"pos": [
4,
23
]
} | {
"id": "C0012702",
"name": "disopyramide",
"pos": [
24,
36
]
} |
the antiarrhythmic effect of oral propafenone was evaluated in 10 patients with wolff-parkinson-white syndrome presenting with non-ventricular arrhythmias ( paroxysmal supraventricular tachycardia n = 7 , atrial fibrillation or flutter n = 3 ) . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
4,
18
]
} | {
"id": "C0033429",
"name": "propafenone",
"pos": [
34,
45
]
} |
continuous infusion of the antidepressants maprotiline or desipramine into the rat cerebral cortex pretreated with the catecholamine neurotoxin 6-hydroxydopamine induced regeneration of noradrenergic axon terminals . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
27,
42
]
} | {
"id": "C0011685",
"name": "desipramine",
"pos": [
58,
69
]
} |
the effect of empiric antiarrhythmic therapy with quinidine and procainamide on long-term mortality was examined in 209 patients with coronary artery disease resuscitated after out-of-hospital cardiac arrest . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
22,
36
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
50,
59
]
} |
the effect of empiric antiarrhythmic therapy with quinidine and procainamide on long-term mortality was examined in 209 patients with coronary artery disease resuscitated after out-of-hospital cardiac arrest . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
22,
36
]
} | {
"id": "C0033216",
"name": "procainamide",
"pos": [
64,
76
]
} |
the antimalarial activity of the proguanil/dapsone combination was assessed in vitro by measuring the inhibition of re-invasion of two plasmodium falciparum isolates grown in the presence of volunteers ' sera . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial",
"pos": [
4,
16
]
} | {
"id": "C0008241",
"name": "proguanil",
"pos": [
33,
42
]
} |
to further our understanding of the mechanisms by which ethambutol potentiates the effect of other antimycobacterial drugs on mycobacteria we have studied the initial physico-chemical interaction between ethambutol and the mycobacterium avium cell envelope using batch reaction microcalorimetry . | therapeutic_class_of | {
"id": "C0360390",
"name": "antimycobacterial",
"pos": [
99,
116
]
} | {
"id": "C0014964",
"name": "ethambutol",
"pos": [
204,
214
]
} |
in-vitro evaluation of the antifungal activity of amphotericin b entrapped into liposomes during storage for one year . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
27,
37
]
} | {
"id": "C0002679",
"name": "amphotericin b",
"pos": [
50,
64
]
} |
the stability of the antifungal activity of amphotericin b entrapped in small sonicated liposomes ( ampholiposomes ) was studied in vitro over a one-year period . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
21,
31
]
} | {
"id": "C0002679",
"name": "amphotericin b",
"pos": [
44,
58
]
} |
judging from the minimal inhibitory concentration of antibiotics against the isolated l. monocytogenes , antibacterial activity of penicillin g and ampicillin was good , whereas that of cefotaxime and latamoxef was poor . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
105,
118
]
} | {
"id": "C0030827",
"name": "penicillin g",
"pos": [
131,
143
]
} |
judging from the minimal inhibitory concentration of antibiotics against the isolated l. monocytogenes , antibacterial activity of penicillin g and ampicillin was good , whereas that of cefotaxime and latamoxef was poor . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
105,
118
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
148,
158
]
} |
judging from the minimal inhibitory concentration of antibiotics against the isolated l. monocytogenes , antibacterial activity of penicillin g and ampicillin was good , whereas that of cefotaxime and latamoxef was poor . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
105,
118
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
186,
196
]
} |
all three atypical neuroleptics studied increased pek mrna in the following order : anterior-cpu , thioridazine greater than clozapine and molindone ; | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
19,
31
]
} | {
"id": "C0026388",
"name": "molindone",
"pos": [
139,
148
]
} |
in order to test this hypothesis , the effects of acute and chronic administration of two antidepressants , a norepinephrine re-uptake inhibitor ( desmethylimipramine , dmi ) and a serotonin re-uptake inhibitor ( sertraline , ser ) , on lc spontaneous discharge , lc sensory evoked discharge , lc activation by a stressor and lc activation by crf , were compared in halothane-anesthetized rats . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
90,
105
]
} | {
"id": "C0011685",
"name": "desmethylimipramine",
"pos": [
147,
166
]
} |
the diphenylbutylpiperidine ( dpbp ) antipsychotic pimozide was identified as a potent new ca2+ channel antagonist in heart . | therapeutic_class_of | {
"id": "C0040615",
"name": "antipsychotic",
"pos": [
37,
50
]
} | {
"id": "C0031935",
"name": "pimozide",
"pos": [
51,
59
]
} |
in general , neuroleptics should be avoided , because of increased risk of convulsions , but haloperidol can be used to control hallucinations and severe agitation . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
13,
25
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
93,
104
]
} |
here , we have investigated the effect of the lipid-soluble antimycobacterial drugs ansamycin , clofazimine and cgp7040 on the thermotropic behavior of liposomes composed of dipalmitoylphosphatidylcholine ( dppc ) or dipalmitoylphosphatidylglycerol ( dppg ) using differential scanning calorimetry ( dsc ) . | therapeutic_class_of | {
"id": "C0360390",
"name": "antimycobacterial",
"pos": [
60,
77
]
} | {
"id": "C0008996",
"name": "clofazimine",
"pos": [
96,
107
]
} |
the present study demonstrates the effects of the antidepressant , amitriptyline , and the acetylcholine antagonist , atropine , on the stimulation-induced rise in cytosolic , free ca2+ ( cai2+ ) . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
50,
64
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
67,
80
]
} |
paroxetine : a selective serotonin reuptake inhibitor showing better tolerance , but weaker antidepressant effect than clomipramine in a controlled multicenter study . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
92,
106
]
} | {
"id": "C0009010",
"name": "clomipramine",
"pos": [
119,
131
]
} |
antidepressant effects and unintended effects of paroxetine ( 30 mg/day ) and clomipramine ( 150 mg/day ) were compared in a double-blind , randomized , inpatient , fixed-dose , plasma-level-controlled study . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
0,
14
]
} | {
"id": "C0009010",
"name": "clomipramine",
"pos": [
78,
90
]
} |
interactions of the oxygen-dependent antimicrobial system of the human neutrophil with difloxacin , ciprofloxacin , pefloxacin and fleroxacin in the intraphagocytic eradication of staphylococcus aureus . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial",
"pos": [
37,
50
]
} | {
"id": "C0008809",
"name": "ciprofloxacin",
"pos": [
100,
113
]
} |
furthermore , these results imply that hr-592 has anti-cataleptogenic activity and might thereby alleviate the adverse effect of neuroleptics such as haloperidol . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
129,
141
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
150,
161
]
} |
antiarrhythmic effect of chronic oral amiodarone treatment in dogs with myocardial infarction and reproducibly inducible sustained ventricular arrhythmias . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
0,
14
]
} | {
"id": "C0002598",
"name": "amiodarone",
"pos": [
38,
48
]
} |
the antiarrhythmic effect of an 8-week oral amiodarone regimen was studied in dogs with 1-week-old myocardial infarction and reproducibly inducible sustained ventricular tachycardia ( vt ) or ventricular fibrillation ( vf ) . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
4,
18
]
} | {
"id": "C0002598",
"name": "amiodarone",
"pos": [
44,
54
]
} |
the lack of antiarrhythmic effect of amiodarone at week 2 coincided with the highest plasma amiodarone concentration . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
12,
26
]
} | {
"id": "C0002598",
"name": "amiodarone",
"pos": [
92,
102
]
} |
the data indicate that this dog model of ventricular arrhythmias is useful for studying the antiarrhythmic action of amiodarone . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
92,
106
]
} | {
"id": "C0002598",
"name": "amiodarone",
"pos": [
117,
127
]
} |
the effects of mianserin , a tetracyclic antidepressant , and adinazolam , a new triazolobenzodiazepine which has antidepressant activity , on intraventricular conduction and the incidence of arrhythmias induced by programmed ventricular stimulation were studied in the dog heart after myocardial infarction and compared to the effects of amitriptyline , a standard tricyclic antidepressant . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
41,
55
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
339,
352
]
} |
most authors agree that a combined approach employing early valve replacement and aggressive antifungal chemotherapy with amphotericin b and perhaps flucytosine or rifampin represents the best option for treatment of endovascular aspergillus infections . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
93,
103
]
} | {
"id": "C0016278",
"name": "flucytosine",
"pos": [
149,
160
]
} |
the anthelmintic efficacy of thiophanate and albendazole was compared in sheep with heavy infestations of dicrocoelium dentriticum . | therapeutic_class_of | {
"id": "C0003158",
"name": "anthelmintic",
"pos": [
4,
16
]
} | {
"id": "C0001911",
"name": "albendazole",
"pos": [
45,
56
]
} |
the antifungal activities of amphotericin b and two triazoles , sch 39304 and fluconazole , were tested against histoplasma capsulatum . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
4,
14
]
} | {
"id": "C0002679",
"name": "amphotericin b",
"pos": [
29,
43
]
} |
when the antimicrobial ability of peritoneal macrophages ( m phi s ) against m. fortuitum was measured in medium with or without ofloxacin , growth of the organisms was more markedly inhibited by ofloxacin in lc9018-induced m phi s than in normal m phi s . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial",
"pos": [
9,
22
]
} | {
"id": "C0028902",
"name": "ofloxacin",
"pos": [
196,
205
]
} |
the antiepileptic drug ( aed ) ethosuximide ( esm ) , known to attenuate ghb-induced swd did so , but had no effect on the hypothermia , whereas ghb-induced hypothermia , but not swd , was blocked by raising the ambient temperature from 26 degrees to 32 degrees c . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drug",
"pos": [
4,
22
]
} | {
"id": "C0015043",
"name": "ethosuximide",
"pos": [
31,
43
]
} |
new aspects of the clinical use of anti-arrhythmia agents with special reference to acute therapy of ventricular tachycardia ( lidocaine vs. ajmaline ) . | therapeutic_class_of | {
"id": "C0003195",
"name": "anti-arrhythmia agents",
"pos": [
35,
57
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
127,
136
]
} |
fever in the remaining 30 % , without evidence of malaria and who failed to respond to chloroquine , fansidar and antibacterials including chloramphenicol , remitted spontaneously . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterials",
"pos": [
114,
128
]
} | {
"id": "C0008168",
"name": "chloramphenicol",
"pos": [
139,
154
]
} |
an 86-year-old man receiving antiarrhythmic treatment with an intravenous ( iv ) lidocaine infusion experienced a prolonged emergence from general anesthesia . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
29,
43
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
81,
90
]
} |
mexiletine is a class ib antiarrhythmic which has basic and clinical electrophysiologic properties similar to lidocaine . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
25,
39
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
110,
119
]
} |
nine of the 10 patients ( one was lost to follow-up ) were treated with antifungal medication , and the effectiveness of ketoconazole therapy is evaluated . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal medication",
"pos": [
72,
93
]
} | {
"id": "C0022625",
"name": "ketoconazole",
"pos": [
121,
133
]
} |
[ current analysis and imposed voltage in the study of anti-arrhythmic properties of quinidine applied to frog myocardium ] . | therapeutic_class_of | {
"id": "C0003195",
"name": "anti-arrhythmic",
"pos": [
55,
70
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
85,
94
]
} |
[ antibacterial activity in vitro and in vivo in animals of a combination of 2 semisynthetic penicillins : dicloxacillin and ethacillin ] . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
2,
15
]
} | {
"id": "C0012093",
"name": "dicloxacillin",
"pos": [
107,
120
]
} |
repeated administration of the antidepressant drugs desipramine , imipramine , phenelzine , zimelidine and mianserin twice daily for 21 days , by contrast , did not affect receptor/n-protein coupling . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
31,
45
]
} | {
"id": "C0011685",
"name": "desipramine",
"pos": [
52,
63
]
} |
repeated administration of the antidepressant drugs desipramine , imipramine , phenelzine , zimelidine and mianserin twice daily for 21 days , by contrast , did not affect receptor/n-protein coupling . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
31,
45
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
66,
76
]
} |
the in vitro antibacterial activity of brl 25000 was superior to ampc against beta-lactamase producing strains . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
13,
26
]
} | {
"id": "C0002645",
"name": "ampc",
"pos": [
65,
69
]
} |
in bacteriological studies a potentiated antibacterial activity of brl 25000 was recognized against ampc-resistant and beta-lactamase producing clinical isolates . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
41,
54
]
} | {
"id": "C0002645",
"name": "ampc",
"pos": [
100,
104
]
} |
an in vitro study of the antibacterial activity of brl 25000 against clinically isolated s. aureus ( 34 strains ) showed higher activity than for ampc alone and demonstrated that cva potentiated the activity of ampc , showing a synergistic effect against beta-lactamase producing organisms . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
25,
38
]
} | {
"id": "C0002645",
"name": "ampc",
"pos": [
211,
215
]
} |
the antibacterial activities of brl 25000 and ampc against 48 strains of e. coli isolated from patients with urinary tract infections were studied . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0002645",
"name": "ampc",
"pos": [
46,
50
]
} |
the antibacterial activities of brl 25000 and amoxicillin ( ampc ) were investigated against clinically isolated and laboratory stocked strains . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0002645",
"name": "amoxicillin",
"pos": [
46,
57
]
} |
the effects of therapeutic doses of antiarrhythmic drugs ( 12 mg/kg of procainamide , 2 mg/kg of disopyramide and 0.2 mg/kg of propranolol ) on sinus cycle length ( scl ) , sinoatrial conduction time ( sact ) estimated by a constant atrial pacing technique , and atrial developed tension ( dt ) were measured in isolated canine atria cross-perfused with heparinized arterial blood from donor dogs as well as on mean systemic blood pressure ( sbp ) and on heart rate ( hr ) in those dogs . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
36,
50
]
} | {
"id": "C0033216",
"name": "procainamide",
"pos": [
71,
83
]
} |
the effects of therapeutic doses of antiarrhythmic drugs ( 12 mg/kg of procainamide , 2 mg/kg of disopyramide and 0.2 mg/kg of propranolol ) on sinus cycle length ( scl ) , sinoatrial conduction time ( sact ) estimated by a constant atrial pacing technique , and atrial developed tension ( dt ) were measured in isolated canine atria cross-perfused with heparinized arterial blood from donor dogs as well as on mean systemic blood pressure ( sbp ) and on heart rate ( hr ) in those dogs . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
36,
50
]
} | {
"id": "C0012702",
"name": "disopyramide",
"pos": [
97,
109
]
} |
thus , cardiac glycosides cause a release of norepinephrine , and the antidepressant drug amitriptyline causes inhibition of prejunctional alpha-adrenoceptors and muscarinic receptors . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant drug",
"pos": [
70,
89
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
90,
103
]
} |
in conclusion , it appears that de gamma e affects alpha-msh levels in plasma in a way distinct from that of the neuroleptic drug haloperidol and of the opiate-peptide beta-endorphin . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic drug",
"pos": [
113,
129
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
130,
141
]
} |
these findings suggest the hypothesis that the catalepsy that is produced by neuroleptics such as haloperidol is actually mediated by intrinsic central cholinergic systems . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
77,
89
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
98,
109
]
} |
despite bupropion 's established dopaminergic activity in vitro and in vivo , it was found that the bupropion cue was neither mimicked by the dopaminergic drugs l-dopa and bromocriptine nor blocked by a variety of neuroleptics ( haloperidol , thioridazine , and thiothixene ) . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
214,
226
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
229,
240
]
} |
despite bupropion 's established dopaminergic activity in vitro and in vivo , it was found that the bupropion cue was neither mimicked by the dopaminergic drugs l-dopa and bromocriptine nor blocked by a variety of neuroleptics ( haloperidol , thioridazine , and thiothixene ) . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
214,
226
]
} | {
"id": "C0039955",
"name": "thiothixene",
"pos": [
262,
273
]
} |
forty-three patients , most with solid tumours , were included in a study comparing the antifungal prophylactic effect of ketoconazole ( nizoral ; janssen ) 200 mg/d and 400 mg/d during the period of immunosuppressive therapy . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
88,
98
]
} | {
"id": "C0022625",
"name": "ketoconazole",
"pos": [
122,
134
]
} |
the antifungal activity of sf 86-327 was compared in vitro with those of naftifine , ketoconazole , and itraconazole ( r 51,211 , janssen pharmaceutica ) by agar dilution . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
4,
14
]
} | {
"id": "C0022625",
"name": "ketoconazole",
"pos": [
85,
97
]
} |
also , the antifungal activities of sf 86-327 and naftifine against 18 dimorphic pathogens were assayed in vitro by broth dilution . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
11,
21
]
} | {
"id": "C0068367",
"name": "dimorphic",
"pos": [
71,
80
]
} |
intravenously given antimicrobial agents active against anaerobes ( tinidazole ) and aerobes ( cefotaxim ) will in combination reduce mortality to less than 15 % . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial agents",
"pos": [
20,
40
]
} | {
"id": "C0040263",
"name": "tinidazole",
"pos": [
68,
78
]
} |
three antidepressant drugs ( amitriptyline , imipramine , clomipramine ) also antagonize 3h-h uptake by hl-60 cells , but this effect was only observed at toxic concentrations ( 10 ( -5 ) m and above ) and was related to a loss of the cell viability . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant drugs",
"pos": [
6,
26
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
29,
42
]
} |
three antidepressant drugs ( amitriptyline , imipramine , clomipramine ) also antagonize 3h-h uptake by hl-60 cells , but this effect was only observed at toxic concentrations ( 10 ( -5 ) m and above ) and was related to a loss of the cell viability . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant drugs",
"pos": [
6,
26
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
45,
55
]
} |
three antidepressant drugs ( amitriptyline , imipramine , clomipramine ) also antagonize 3h-h uptake by hl-60 cells , but this effect was only observed at toxic concentrations ( 10 ( -5 ) m and above ) and was related to a loss of the cell viability . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant drugs",
"pos": [
6,
26
]
} | {
"id": "C0009010",
"name": "clomipramine",
"pos": [
58,
70
]
} |
incessant vt did not develop in any of these patients in the absence of antiarrhythmic drugs or on antiarrhythmic drugs other than propafenone . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drugs",
"pos": [
72,
92
]
} | {
"id": "C0033429",
"name": "propafenone",
"pos": [
131,
142
]
} |
the in vitro and in vivo antibacterial activities of carumonam ( ama-1080 ) , a synthetic sulfazecin derivative , were compared with those of aztreonam , cefoperazone , ceftazidime , and cefsulodin . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
25,
38
]
} | {
"id": "C0004521",
"name": "aztreonam",
"pos": [
142,
151
]
} |
the in vitro and in vivo antibacterial activities of carumonam ( ama-1080 ) , a synthetic sulfazecin derivative , were compared with those of aztreonam , cefoperazone , ceftazidime , and cefsulodin . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
25,
38
]
} | {
"id": "C0007552",
"name": "cefoperazone",
"pos": [
154,
166
]
} |
the in vitro and in vivo antibacterial activities of carumonam ( ama-1080 ) , a synthetic sulfazecin derivative , were compared with those of aztreonam , cefoperazone , ceftazidime , and cefsulodin . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
25,
38
]
} | {
"id": "C0007559",
"name": "ceftazidime",
"pos": [
169,
180
]
} |
initial treatment with sedatives ( diazepam ) and antipsychotics ( haloperidol and thioridazine hydrochloride ) did not diminish this irritability or destructive behavior . | therapeutic_class_of | {
"id": "C0040615",
"name": "antipsychotics",
"pos": [
50,
64
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
67,
78
]
} |
the antimalarial drugs chloroquine and the quinine and the aminoglycoside antibiotics gentamicin and neomycin all of which , like zn2+ , have been shown to block neuromuscular transmission , also inhibited the enzyme . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial drugs",
"pos": [
4,
22
]
} | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
23,
34
]
} |
these findings indicate that the chronic administration of the atypical neuroleptic clozapine does not produce changes in brain dopamine function which mirror those of the typical neuroleptic haloperidol . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
72,
83
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
192,
203
]
} |
there is evidence that some antidepressant drugs , above all amitriptyline and mianserine , are beneficial in the prophylaxis of migraine . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant drugs",
"pos": [
28,
48
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
61,
74
]
} |
the in vitro antibacterial activity of aztreonam ( sq 26776 ) , a new beta-lactam antibiotic , was measured by the agar dilution technique . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
13,
26
]
} | {
"id": "C0004521",
"name": "aztreonam",
"pos": [
39,
48
]
} |
the antimalarial drug , primaquine , the side chain of which is structurally analogous to a natural polyamine , did not enhance the activity of alpha-difluoromethylornithine or alpha-monofluoromethyldehydroornithine methyl ester . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial drug",
"pos": [
4,
21
]
} | {
"id": "C0033126",
"name": "primaquine",
"pos": [
24,
34
]
} |
the antibacterial activity of cmnx against bacteroides fragilis was comparable to that of latamoxef and superior to cefoxitin , but cmnx 's activity against anaerobic cocci was slightly inferior to cefoxitin 's ; | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0007557",
"name": "cefoxitin 's",
"pos": [
198,
210
]
} |
the influence on the antibacterial activity of introducing a 6 alpha-methoxy group into carbenicillin , and various 6 alpha-substituents into sulbenicillin and piperacillin was examined . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
21,
34
]
} | {
"id": "C0006976",
"name": "carbenicillin",
"pos": [
88,
101
]
} |
the influence on the antibacterial activity of introducing a 6 alpha-methoxy group into carbenicillin , and various 6 alpha-substituents into sulbenicillin and piperacillin was examined . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
21,
34
]
} | {
"id": "C0031955",
"name": "piperacillin",
"pos": [
160,
172
]
} |
further controlled studies are needed before the antimanic and prophylactic efficacy of carbamazepine can be regarded as conclusively established . | therapeutic_class_of | {
"id": "C0242911",
"name": "antimanic",
"pos": [
49,
58
]
} | {
"id": "C0006949",
"name": "carbamazepine",
"pos": [
88,
101
]
} |
we describe a method for the simultaneous determination of valproic acid with four other antiepileptic drugs ( phenobarbital , phenytoin , carbamazepine , and primidone ) in plasma by high-performance liquid chromatography . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drugs",
"pos": [
89,
108
]
} | {
"id": "C0031507",
"name": "phenytoin",
"pos": [
127,
136
]
} |
we describe a method for the simultaneous determination of valproic acid with four other antiepileptic drugs ( phenobarbital , phenytoin , carbamazepine , and primidone ) in plasma by high-performance liquid chromatography . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drugs",
"pos": [
89,
108
]
} | {
"id": "C0033148",
"name": "primidone",
"pos": [
159,
168
]
} |
the present paper reviews gas and liquid chromatographic methods for the determination of the most commonly monitored antiepileptic drugs : phenobarbital , phenytoin , carbamazepine , primidone , ethosuximide , valproic acid and clonazepam along with a new compound , progabide . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drugs",
"pos": [
118,
137
]
} | {
"id": "C0031507",
"name": "phenytoin",
"pos": [
156,
165
]
} |
the present paper reviews gas and liquid chromatographic methods for the determination of the most commonly monitored antiepileptic drugs : phenobarbital , phenytoin , carbamazepine , primidone , ethosuximide , valproic acid and clonazepam along with a new compound , progabide . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drugs",
"pos": [
118,
137
]
} | {
"id": "C0033148",
"name": "primidone",
"pos": [
184,
193
]
} |
the present paper reviews gas and liquid chromatographic methods for the determination of the most commonly monitored antiepileptic drugs : phenobarbital , phenytoin , carbamazepine , primidone , ethosuximide , valproic acid and clonazepam along with a new compound , progabide . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drugs",
"pos": [
118,
137
]
} | {
"id": "C0015043",
"name": "ethosuximide",
"pos": [
196,
208
]
} |
the present paper reviews gas and liquid chromatographic methods for the determination of the most commonly monitored antiepileptic drugs : phenobarbital , phenytoin , carbamazepine , primidone , ethosuximide , valproic acid and clonazepam along with a new compound , progabide . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drugs",
"pos": [
118,
137
]
} | {
"id": "C0042291",
"name": "valproic acid",
"pos": [
211,
224
]
} |
this review examines the comparative effects of lithium and neuroleptics and the combination of lithium with ( i ) haloperidol , ( ii ) carbamazepine and ( iii ) l-tryptophan in the treatment of mania . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
60,
72
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
115,
126
]
} |
to determine whether failure of procainamide to prevent initiation of ventricular tachyarrhythmias during electrophysiologic testing predicted failure of other antiarrhythmic regimens , 81 consecutive patients with coronary artery disease whose ventricular tachyarrhythmias remained inducible during procainamide administration were studied . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
160,
174
]
} | {
"id": "C0033216",
"name": "procainamide",
"pos": [
300,
312
]
} |
in contrast , chronic ( 14 day ) administration with either the gaba-a receptor agonist thip or the antidepressant imipramine failed to alter the increase in beta-adrenergic receptor binding produced by dsp4 pretreatment . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
100,
114
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
115,
125
]
} |
inhibition of [ 3h ] -5-ht uptake by a number of clinically effective antidepressants was also consistent with a specific high affinity uptake mechanism for 5-ht , the order of effectiveness of inhibition being chlorimipramine greater than fluoxetine greater than imipramine = amitriptyline greater than desmethylimipramine greater than iprindole greater than mianserin . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
70,
85
]
} | {
"id": "C0009010",
"name": "chlorimipramine",
"pos": [
211,
226
]
} |
inhibition of [ 3h ] -5-ht uptake by a number of clinically effective antidepressants was also consistent with a specific high affinity uptake mechanism for 5-ht , the order of effectiveness of inhibition being chlorimipramine greater than fluoxetine greater than imipramine = amitriptyline greater than desmethylimipramine greater than iprindole greater than mianserin . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
70,
85
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
313,
323
]
} |
inhibition of [ 3h ] -5-ht uptake by a number of clinically effective antidepressants was also consistent with a specific high affinity uptake mechanism for 5-ht , the order of effectiveness of inhibition being chlorimipramine greater than fluoxetine greater than imipramine = amitriptyline greater than desmethylimipramine greater than iprindole greater than mianserin . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
70,
85
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
277,
290
]
} |
inhibition of [ 3h ] -5-ht uptake by a number of clinically effective antidepressants was also consistent with a specific high affinity uptake mechanism for 5-ht , the order of effectiveness of inhibition being chlorimipramine greater than fluoxetine greater than imipramine = amitriptyline greater than desmethylimipramine greater than iprindole greater than mianserin . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
70,
85
]
} | {
"id": "C0011685",
"name": "desmethylimipramine",
"pos": [
304,
323
]
} |
vmax of the action potential upstroke in canine cardiac purkinje fibers was studied in the presence of seven class i antiarrhythmic drugs -- lidocaine ( 4 micrograms/ml ) , mexiletine ( 4 micrograms/ml ) , propranolol ( 0.9 micrograms/ml ) , procainamide ( 30 micrograms/ml ) , quinidine ( 5 micrograms/ml ) , flecainide ( 4 micrograms/ml ) , and disopyramide ( 3.1 micrograms/ml ) -- at constant cycle lengths ( ccl ) and after abrupt changes in cycle length ( accl ) . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
117,
131
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
141,
150
]
} |
vmax of the action potential upstroke in canine cardiac purkinje fibers was studied in the presence of seven class i antiarrhythmic drugs -- lidocaine ( 4 micrograms/ml ) , mexiletine ( 4 micrograms/ml ) , propranolol ( 0.9 micrograms/ml ) , procainamide ( 30 micrograms/ml ) , quinidine ( 5 micrograms/ml ) , flecainide ( 4 micrograms/ml ) , and disopyramide ( 3.1 micrograms/ml ) -- at constant cycle lengths ( ccl ) and after abrupt changes in cycle length ( accl ) . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
117,
131
]
} | {
"id": "C0025887",
"name": "mexiletine",
"pos": [
173,
183
]
} |
vmax of the action potential upstroke in canine cardiac purkinje fibers was studied in the presence of seven class i antiarrhythmic drugs -- lidocaine ( 4 micrograms/ml ) , mexiletine ( 4 micrograms/ml ) , propranolol ( 0.9 micrograms/ml ) , procainamide ( 30 micrograms/ml ) , quinidine ( 5 micrograms/ml ) , flecainide ( 4 micrograms/ml ) , and disopyramide ( 3.1 micrograms/ml ) -- at constant cycle lengths ( ccl ) and after abrupt changes in cycle length ( accl ) . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
117,
131
]
} | {
"id": "C0033216",
"name": "procainamide",
"pos": [
242,
254
]
} |
vmax of the action potential upstroke in canine cardiac purkinje fibers was studied in the presence of seven class i antiarrhythmic drugs -- lidocaine ( 4 micrograms/ml ) , mexiletine ( 4 micrograms/ml ) , propranolol ( 0.9 micrograms/ml ) , procainamide ( 30 micrograms/ml ) , quinidine ( 5 micrograms/ml ) , flecainide ( 4 micrograms/ml ) , and disopyramide ( 3.1 micrograms/ml ) -- at constant cycle lengths ( ccl ) and after abrupt changes in cycle length ( accl ) . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
117,
131
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
278,
287
]
} |
vmax of the action potential upstroke in canine cardiac purkinje fibers was studied in the presence of seven class i antiarrhythmic drugs -- lidocaine ( 4 micrograms/ml ) , mexiletine ( 4 micrograms/ml ) , propranolol ( 0.9 micrograms/ml ) , procainamide ( 30 micrograms/ml ) , quinidine ( 5 micrograms/ml ) , flecainide ( 4 micrograms/ml ) , and disopyramide ( 3.1 micrograms/ml ) -- at constant cycle lengths ( ccl ) and after abrupt changes in cycle length ( accl ) . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
117,
131
]
} | {
"id": "C0016229",
"name": "flecainide",
"pos": [
310,
320
]
} |
vmax of the action potential upstroke in canine cardiac purkinje fibers was studied in the presence of seven class i antiarrhythmic drugs -- lidocaine ( 4 micrograms/ml ) , mexiletine ( 4 micrograms/ml ) , propranolol ( 0.9 micrograms/ml ) , procainamide ( 30 micrograms/ml ) , quinidine ( 5 micrograms/ml ) , flecainide ( 4 micrograms/ml ) , and disopyramide ( 3.1 micrograms/ml ) -- at constant cycle lengths ( ccl ) and after abrupt changes in cycle length ( accl ) . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
117,
131
]
} | {
"id": "C0012702",
"name": "disopyramide",
"pos": [
347,
359
]
} |
thirty-two metabolites and analogues of the antiepileptic drug valproic acid ( 2-propylpentanoic acid ; vpa ) were tested for anticonvulsant and toxic effects in mice , in an attempt to find out if any of these compounds were superior to valproic acid . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drug",
"pos": [
44,
62
]
} | {
"id": "C0042291",
"name": "valproic acid",
"pos": [
238,
251
]
} |
the time course of the blockade of sodium currents ( ina ) by the antiarrhythmic agents , lignocaine and sun 1165 , was studied in single myocytes isolated enzymatically from guinea-pig atrium , by a new concentration-jump termed as a 'concentration-clamp ' technique . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agents",
"pos": [
66,
87
]
} | {
"id": "C0023660",
"name": "lignocaine",
"pos": [
90,
100
]
} |
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