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effects of a new antiarrhythmic agent , opc-88117 , on the conduction properties and excitability of langendorff-perfused rabbit hearts were compared with those of lignocaine . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agent",
"pos": [
17,
37
]
} | {
"id": "C0023660",
"name": "lignocaine",
"pos": [
164,
174
]
} |
antiarrhythmic drugs of class i may be subdivided into those with a short recovery time of na+ channels ( lidocaine-type ) , those with an intermediate recovery time , such as quinidine and newer antiarrhythmics such as flecainide and propafenone , and those with a recovery time greatly exceeding 1 s , such as disopyramide and prajmaline . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmics",
"pos": [
196,
211
]
} | {
"id": "C0016229",
"name": "flecainide",
"pos": [
220,
230
]
} |
antiarrhythmic drugs of class i may be subdivided into those with a short recovery time of na+ channels ( lidocaine-type ) , those with an intermediate recovery time , such as quinidine and newer antiarrhythmics such as flecainide and propafenone , and those with a recovery time greatly exceeding 1 s , such as disopyramide and prajmaline . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmics",
"pos": [
196,
211
]
} | {
"id": "C0033429",
"name": "propafenone",
"pos": [
235,
246
]
} |
antiarrhythmic drugs of class i may be subdivided into those with a short recovery time of na+ channels ( lidocaine-type ) , those with an intermediate recovery time , such as quinidine and newer antiarrhythmics such as flecainide and propafenone , and those with a recovery time greatly exceeding 1 s , such as disopyramide and prajmaline . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmics",
"pos": [
196,
211
]
} | {
"id": "C0012702",
"name": "disopyramide",
"pos": [
312,
324
]
} |
antiarrhythmic efficacy and tolerance of oral propafenone in patients with frequent ventricular arrhythmias : experience of a multicentre study . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
0,
14
]
} | {
"id": "C0033429",
"name": "propafenone",
"pos": [
46,
57
]
} |
the high frequency of drug resistance in this phage type has been shown to be due to the presence of plasmids belonging to inc n and coding for resistance to a range of antimicrobial drugs among which resistance to ampicillin , streptomycin , tetracycline ( ast ) and t predominate . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial drugs",
"pos": [
169,
188
]
} | {
"id": "C0039644",
"name": "tetracycline",
"pos": [
243,
255
]
} |
three standard antimalarials pyrimethamine , primaquine and quinine were tested against p. berghei ( nk 65 ) for gametocytocidal and sporontocidal action . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarials",
"pos": [
15,
28
]
} | {
"id": "C0033126",
"name": "primaquine",
"pos": [
45,
55
]
} |
epididymitis is described in a man aged 33 who had been treated with the antiarrhythmic agent , amiodarone . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agent",
"pos": [
73,
93
]
} | {
"id": "C0002598",
"name": "amiodarone",
"pos": [
96,
106
]
} |
antimicrobial sensitivity of 71 staph . aureus strains tested showed high degree of resistance to erythromycin ( 38.3 % ) . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial",
"pos": [
0,
13
]
} | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
98,
110
]
} |
compressed organ autoradiography has been used to determine whether the anthelmintic drug praziquantel ( pzq ) modifies the migration of isotopically labelled schistosoma mansoni during the first 16 days of infection in cba/ca mice . | therapeutic_class_of | {
"id": "C0003158",
"name": "anthelmintic drug",
"pos": [
72,
89
]
} | {
"id": "C0032911",
"name": "praziquantel",
"pos": [
90,
102
]
} |
these results demonstrate that meropenem has excellent antibacterial activity in vivo in both normal and immunocompromised animals and in some models of infection is superior to imipenem . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
55,
68
]
} | {
"id": "C0020933",
"name": "imipenem",
"pos": [
178,
186
]
} |
the antibacterial activity in vitro of meropenem was compared with another carbapenem , imipenem , the penem hre 664 , and ceftazidime . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0020933",
"name": "imipenem",
"pos": [
88,
96
]
} |
the antibacterial activity in vitro of meropenem was compared with another carbapenem , imipenem , the penem hre 664 , and ceftazidime . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0007559",
"name": "ceftazidime",
"pos": [
123,
134
]
} |
a multiresidue method for the isolation and liquid chromatographic determination of 7 benzimidazole anthelmintics ( thiabendazole , oxfendazole , para-hydroxyfenbendazole , fenbendazole sulfone , mebendazole , albendazole , and fenbendazole ) in milk is presented . | therapeutic_class_of | {
"id": "C0003158",
"name": "anthelmintics",
"pos": [
100,
113
]
} | {
"id": "C0025023",
"name": "mebendazole",
"pos": [
196,
207
]
} |
a multiresidue method for the isolation and liquid chromatographic determination of 7 benzimidazole anthelmintics ( thiabendazole , oxfendazole , para-hydroxyfenbendazole , fenbendazole sulfone , mebendazole , albendazole , and fenbendazole ) in milk is presented . | therapeutic_class_of | {
"id": "C0003158",
"name": "anthelmintics",
"pos": [
100,
113
]
} | {
"id": "C0001911",
"name": "albendazole",
"pos": [
210,
221
]
} |
treatment usually requires a combination of surgical excision and systemic antifungal therapy with amphotericin b . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
75,
85
]
} | {
"id": "C0002679",
"name": "amphotericin b",
"pos": [
99,
113
]
} |
in the current study , the chronopharmacokinetic profiles of an antipyretic agent , pranoprofen , and an antiarrhythmic agent , procainamide , were examined . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agent",
"pos": [
105,
125
]
} | {
"id": "C0033216",
"name": "procainamide",
"pos": [
128,
140
]
} |
the incidence of drug-induced congestive heart failure with several newer antiarrhythmic agents including encainide , ethmozine , lorcainide , mexiletine , propafenone and tocainide was determined in a group of 407 patients who underwent 1,133 drug tests . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agents",
"pos": [
74,
95
]
} | {
"id": "C0025887",
"name": "mexiletine",
"pos": [
143,
153
]
} |
the incidence of drug-induced congestive heart failure with several newer antiarrhythmic agents including encainide , ethmozine , lorcainide , mexiletine , propafenone and tocainide was determined in a group of 407 patients who underwent 1,133 drug tests . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agents",
"pos": [
74,
95
]
} | {
"id": "C0033429",
"name": "propafenone",
"pos": [
156,
167
]
} |
finally , cephalexin represents an additional valuable antibacterial drug in postcoital prophylaxis along with cotrimoxazole , nitrofurantoin and cinoxacin . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial drug",
"pos": [
55,
73
]
} | {
"id": "C0028156",
"name": "nitrofurantoin",
"pos": [
127,
141
]
} |
antibacterial activities of cxd and cet , however , were not tested against methicillin resistant s. aureus ( mrsa ) or cez resistant e. coli and k. pneumoniae . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
0,
13
]
} | {
"id": "C0007546",
"name": "cez",
"pos": [
120,
123
]
} |
antibacterial activities of r-3746 ( na-salt of cefpodoxime ( cpdx ] against clinically isolated strains of streptococcus pneumoniae , streptococcus pyogenes , staphylococcus aureus , enterococcus faecalis , branhamella catarrhalis , escherichia coli , proteus mirabilis and haemophilus influenzae were compared with those of cefaclor , cephalexin and cefadroxil . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
0,
13
]
} | {
"id": "C0007537",
"name": "cefaclor",
"pos": [
326,
334
]
} |
antibacterial activities of r-3746 ( na-salt of cefpodoxime ( cpdx ] against clinically isolated strains of streptococcus pneumoniae , streptococcus pyogenes , staphylococcus aureus , enterococcus faecalis , branhamella catarrhalis , escherichia coli , proteus mirabilis and haemophilus influenzae were compared with those of cefaclor , cephalexin and cefadroxil . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
0,
13
]
} | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
337,
347
]
} |
antibacterial activities of r-3746 ( na-salt of cefpodoxime ( cpdx ] against clinically isolated strains of streptococcus pneumoniae , streptococcus pyogenes , staphylococcus aureus , enterococcus faecalis , branhamella catarrhalis , escherichia coli , proteus mirabilis and haemophilus influenzae were compared with those of cefaclor , cephalexin and cefadroxil . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
0,
13
]
} | {
"id": "C0007538",
"name": "cefadroxil",
"pos": [
352,
362
]
} |
thus , r-3746 showed an antibacterial activity slightly weaker than mcipc and dmppc but similar to ccl , cex and cdx . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
24,
37
]
} | {
"id": "C0007537",
"name": "ccl",
"pos": [
99,
102
]
} |
thus , r-3746 showed an antibacterial activity slightly weaker than mcipc and dmppc but similar to ccl , cex and cdx . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
24,
37
]
} | {
"id": "C0007716",
"name": "cex",
"pos": [
105,
108
]
} |
thus , r-3746 showed an antibacterial activity slightly weaker than mcipc and dmppc but similar to ccl , cex and cdx . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
24,
37
]
} | {
"id": "C0007538",
"name": "cdx",
"pos": [
113,
116
]
} |
antibacterial activities antibacterial activities of cftm against staphylococcus aureus and streptococcus pyogenes were studied comparatively with activities of cefaclor ( ccl ) , cephalexin ( cex ) and ampicillin ( abpc ) . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
0,
13
]
} | {
"id": "C0007537",
"name": "cefaclor",
"pos": [
161,
169
]
} |
antibacterial activities antibacterial activities of cftm against staphylococcus aureus and streptococcus pyogenes were studied comparatively with activities of cefaclor ( ccl ) , cephalexin ( cex ) and ampicillin ( abpc ) . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
0,
13
]
} | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
180,
190
]
} |
antibacterial activities antibacterial activities of cftm against staphylococcus aureus and streptococcus pyogenes were studied comparatively with activities of cefaclor ( ccl ) , cephalexin ( cex ) and ampicillin ( abpc ) . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
0,
13
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
203,
213
]
} |
the antibacterial potency was very good against haemophilus influenzae , streptococcus pyogenes and streptococcus pneumoniae , and was comparable with cephalexin against staphylococcus aureus . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
151,
161
]
} |
the antibacterial activity of cftm was superior to those of ccl and cex , and was superior against gram-negative rods and equal against gram-positive cocci to those of abpc . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0007537",
"name": "ccl",
"pos": [
60,
63
]
} |
the antibacterial activity of cftm was superior to those of ccl and cex , and was superior against gram-negative rods and equal against gram-positive cocci to those of abpc . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0007716",
"name": "cex",
"pos": [
68,
71
]
} |
the antibacterial activity of cftm was superior to those of ccl and cex , and was superior against gram-negative rods and equal against gram-positive cocci to those of abpc . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0002680",
"name": "abpc",
"pos": [
168,
172
]
} |
cldm which has strong antibacterial spectrum against gram-positive and anaerobic bacteria , was chosen as a partner of azt in order to complement the weak points of azt . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
22,
35
]
} | {
"id": "C0004521",
"name": "azt",
"pos": [
165,
168
]
} |
in 5 patients no antiarrhythmic agent was used during this study , and in 3 patients procainamide was administrated intravenously . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agent",
"pos": [
17,
37
]
} | {
"id": "C0033216",
"name": "procainamide",
"pos": [
85,
97
]
} |
the properties of a class 1c antiarrhythmic drug , flecainide , were examined using 3 canine ventricular arrhythmia models : ( 1 ) digitalis- , ( 2 ) adrenaline- and ( 3 ) two-stage coronary ligation-induced arrhythmias . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drug",
"pos": [
29,
48
]
} | {
"id": "C0016229",
"name": "flecainide",
"pos": [
51,
61
]
} |
the sigma receptor , which is labeled with ( + ) - [ 3h ] 3- ( 3-hydroxyphenyl ) -n- 1- ( propyl ) piperidine [ ( + ) - [ 3h ] 3-ppp ] , is a site that binds several psychotomimetic opiate benzomorphans and certain antipsychotics , such as haloperidol . | therapeutic_class_of | {
"id": "C0040615",
"name": "antipsychotics",
"pos": [
215,
229
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
240,
251
]
} |
the antipsychotics haloperidol and chlorpromazine inhibit ( + ) - [ 3h ] 3-ppp binding in a manner indicating interaction with a single state of the receptor . | therapeutic_class_of | {
"id": "C0040615",
"name": "antipsychotics",
"pos": [
4,
18
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
19,
30
]
} |
measurements were carried out prior to and after 6 weeks ' treatment with the antidepressants clomipramine or maprotiline ( randomized double-blind trial ) . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
78,
93
]
} | {
"id": "C0009010",
"name": "clomipramine",
"pos": [
94,
106
]
} |
the monobactam antibacterial agent aztreonam is used both as single-agent therapy and in combination with other drugs . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial agent",
"pos": [
15,
34
]
} | {
"id": "C0004521",
"name": "aztreonam",
"pos": [
35,
44
]
} |
actions and interactions of two antidepressants and diazepam on human skilled performance and mood were studied in a randomized double-blind cross-over trial with single oral doses of 50 mg amitriptyline ( ami ) , 15 mg org 3770 ( org ) and placebo , given alone and in combination with 15 mg diazepam ( dz ) to 12 young healthy subjects at one-week intervals . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
32,
47
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
190,
203
]
} |
these antibacterial properties relate cfm to the third generation cephalosporins and position the compound in an excellent place among the orally active cephalosporins . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
6,
19
]
} | {
"id": "C0060400",
"name": "cfm",
"pos": [
38,
41
]
} |
[ antibacterial effect of cefixime in the presence of the type of beta-lactamases produced by enterobacteriaceae ] . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
2,
15
]
} | {
"id": "C0060400",
"name": "cefixime",
"pos": [
26,
34
]
} |
the antidepressive effect of hydiphen was evaluated and compared with imipramine in patients with endogenous depression . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressive",
"pos": [
4,
18
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
70,
80
]
} |
in order to evaluate the influence of some neuroleptics on unproductive symptoms of schizophrenic process , first hospitalized patients with paranoid schizophrenia underwent monotherapy with perazine , fluphenazine , trifluoroperazine , chlorpromazine , and haloperidol . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
43,
55
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
258,
269
]
} |
since two different antidepressant treatments , desipramine ( dmi ) and electroconvulsive shock ( ecs ) , are known to alter monoaminergic function in the rat central nervous system ( cns ) , the effects of dmi and ecs on the function of the hpt axis in the rat were examined . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
20,
34
]
} | {
"id": "C0011685",
"name": "desipramine",
"pos": [
48,
59
]
} |
however , it does appear that while clozapine efficacy in treatment-resistant schizophrenic patients in general is superior to such neuroleptics as chlorpromazine or haloperidol , the `` '' paranoid '' '' subgroup appears to benefit most . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
132,
144
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
166,
177
]
} |
supplied with their own blood , beating hearts were manipulated in three different ways : direct current impulses ( 4.5 v , 750 ms ) or programmed ventricular stimulation , creation of a small myocardial infarction , and application of antiarrhythmic drugs ( ajmalin , lidocaine , sotalol ) . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drugs",
"pos": [
236,
256
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
269,
278
]
} |
supplied with their own blood , beating hearts were manipulated in three different ways : direct current impulses ( 4.5 v , 750 ms ) or programmed ventricular stimulation , creation of a small myocardial infarction , and application of antiarrhythmic drugs ( ajmalin , lidocaine , sotalol ) . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drugs",
"pos": [
236,
256
]
} | {
"id": "C0037707",
"name": "sotalol",
"pos": [
281,
288
]
} |
liposomal-ionophores , however , showed antifungal activity along with low concentrations of amphotericin b indicating the presence of synergism between these drugs . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
40,
50
]
} | {
"id": "C0002679",
"name": "amphotericin b",
"pos": [
93,
107
]
} |
we report on a 46-year-old woman with ventricular tachycardia and ventricular fibrillation after starting antiarrhythmic drug therapy with flecainide . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drug",
"pos": [
106,
125
]
} | {
"id": "C0016229",
"name": "flecainide",
"pos": [
139,
149
]
} |
antiarrhythmic activity of n-propionylprocainamide , not being inferior to that of procainamide and n-acetylprocainamide , and lesser side effects of n-propionylprocainamide indicate for advisability of further studies of this compound . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
0,
14
]
} | {
"id": "C0033216",
"name": "procainamide",
"pos": [
161,
173
]
} |
antimicrobial agents ( rifampin , rifabutin [ ansamycin ] , ethambutol , ciprofloxacin , clofazimine , isoniazid , and amikacin ) were tested using concentrations that are achievable in the serum of patients . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial agents",
"pos": [
0,
20
]
} | {
"id": "C0008809",
"name": "ciprofloxacin",
"pos": [
73,
86
]
} |
new macrolide derivatives also show promise to expand the antimicrobial spectrum of erythromycin to include mycobacterium and borrelia spp . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial",
"pos": [
58,
71
]
} | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
84,
96
]
} |
bo-1341 , a new antipseudomonal semisynthetic cephalosporin , was evaluated for in vitro and in vivo antibacterial activities in comparison with ceftazidime , cefotaxime , and cefoperazone . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
101,
114
]
} | {
"id": "C0007559",
"name": "ceftazidime",
"pos": [
145,
156
]
} |
bo-1341 , a new antipseudomonal semisynthetic cephalosporin , was evaluated for in vitro and in vivo antibacterial activities in comparison with ceftazidime , cefotaxime , and cefoperazone . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
101,
114
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
159,
169
]
} |
bo-1341 , a new antipseudomonal semisynthetic cephalosporin , was evaluated for in vitro and in vivo antibacterial activities in comparison with ceftazidime , cefotaxime , and cefoperazone . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
101,
114
]
} | {
"id": "C0007552",
"name": "cefoperazone",
"pos": [
176,
188
]
} |
in a previous study , we demonstrated that diclofenac increased the extravascular diffusion and antibacterial efficacy of ceftriaxone without any effect on serum protein binding and urinary excretion of this antibiotic . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
96,
109
]
} | {
"id": "C0007561",
"name": "ceftriaxone",
"pos": [
122,
133
]
} |
thus , encapsulation into unilamellar liposomes enhances the antifungal efficacy of amphotericin b while reducing the toxicity normally associated with administration of free amphotericin b . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
61,
71
]
} | {
"id": "C0002679",
"name": "amphotericin b",
"pos": [
175,
189
]
} |
antibacterial activity of eremomycin against methicillin resistant strains of staphylococci was 4 times higher than that of teichoplanin and vancomycin . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
0,
13
]
} | {
"id": "C0042313",
"name": "vancomycin",
"pos": [
141,
151
]
} |
thirty one patients aged 56 +/- 16 years with chronic ventricular tachycardias ( vt ) refractory to 4.4 +/- 1.8 antiarrhythmic drugs , used alone or in combination , were managed by low doses of beta-blocker agents combined with oral amiodarone , either after loading ( 1.2 g for 7 days , n : 7 ) or reloading ( 1.2 g for 4 days , n : 24 ) of amiodarone . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drugs",
"pos": [
112,
132
]
} | {
"id": "C0002598",
"name": "amiodarone",
"pos": [
343,
353
]
} |
in order to assess the value of the various atrial pacing techniques employed to evaluate the anterograde conduction of the accessory pathway and the effect of antiarrhythmic agents in wolff-parkinson-white syndrome , transesophageal atrial pacing was performed in 12 patients before and during treatment with oral flecainide acetate in doses of 200 mg per day . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agents",
"pos": [
160,
181
]
} | {
"id": "C0086303",
"name": "flecainide acetate",
"pos": [
315,
333
]
} |
these results indicate that the cardiac sarcolemmal na+-ca2+ exchange system may be one of the sites for the antiarrhythmic actions of quinidine and procainamide . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
109,
123
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
135,
144
]
} |
these results indicate that the cardiac sarcolemmal na+-ca2+ exchange system may be one of the sites for the antiarrhythmic actions of quinidine and procainamide . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
109,
123
]
} | {
"id": "C0033216",
"name": "procainamide",
"pos": [
149,
161
]
} |
the effect of the anticonvulsant , anti-manic drug carbamazepine was examined on inositol lipid signalling in rat hippocampus in vitro . | therapeutic_class_of | {
"id": "C0242911",
"name": "anti-manic",
"pos": [
35,
45
]
} | {
"id": "C0006949",
"name": "carbamazepine",
"pos": [
51,
64
]
} |
after antibacterial therapy with bismuth subsalicylate , amoxicillin , and metronidazole , the organisms disappeared in both patients and the gastritis healed . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
6,
19
]
} | {
"id": "C0002645",
"name": "amoxicillin",
"pos": [
57,
68
]
} |
[ antiarrhythmic effect of beta-n-hexamethyleneimino-para-butoxypropiophenone ( tg-17 ) , novocainamide and quinidine in cardiac arrhythmias evoked by strophanthin k in cats ] . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
2,
16
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
108,
117
]
} |
a comparison of the antibacterial effect of nitrofurantoin and two nitrofuran compounds on experimental escherichia coli pyelonephritis . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
20,
33
]
} | {
"id": "C0028156",
"name": "nitrofurantoin",
"pos": [
44,
58
]
} |
clinical evaluation of a new topical antibacterial preparation , gentamicin sulphate ointment on diseases of the skin due to infection with pus cocci . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
37,
50
]
} | {
"id": "C0546866",
"name": "gentamicin",
"pos": [
65,
75
]
} |
[ study on the clinical use and the mode of action of antimalarials ( chloroquine ) outside of their chemotherapeutic indications ] . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarials",
"pos": [
54,
67
]
} | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
70,
81
]
} |
[ on antibacterial treatment at the level of the urinary tract : case history , preventive and therapeutic contribution , with nitrofurantoin by oral route ] . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
5,
18
]
} | {
"id": "C0028156",
"name": "nitrofurantoin",
"pos": [
127,
141
]
} |
the influence of the antifungal agent miconazole nitrate on yeast plasma membranes was studied in a concentration range 0-100 microm . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal agent",
"pos": [
21,
37
]
} | {
"id": "C0086620",
"name": "miconazole nitrate",
"pos": [
38,
56
]
} |
free drug fractions of two antiarrhythmic agents with contrasting binding characteristics , quinidine and procainamide , were related to free fatty acid and alpha 1-glycoprotein concentrations on days 1 through 5 and 10 in 20 patients with acute myocardial infarction . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agents",
"pos": [
27,
48
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
92,
101
]
} |
free drug fractions of two antiarrhythmic agents with contrasting binding characteristics , quinidine and procainamide , were related to free fatty acid and alpha 1-glycoprotein concentrations on days 1 through 5 and 10 in 20 patients with acute myocardial infarction . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agents",
"pos": [
27,
48
]
} | {
"id": "C0033216",
"name": "procainamide",
"pos": [
106,
118
]
} |
although the antibacterial activity of desacetylcefotaxime ( des-ctx ) , the principal metabolite of cefotaxime ( ctx ) , is eightfold lower than cefotaxime , the metabolite inhibits many b-lactamase-producing enterobacteriaceae and unusual pseudomonas species resistant to agents such as cefamandole , cefoxitin , and cefoperazone . des-ctx is more stable than ctx to attack by beta-lactamases of some species such as bacteroides fragilis , proteus vulgaris , and the k-1 enzyme of enterobacter-klebsiella . des-ctx acts synergistically with ctx against many enterobacteriaceae and streptococcus faecalis . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
13,
26
]
} | {
"id": "C0007557",
"name": "cefoxitin",
"pos": [
303,
312
]
} |
although the antibacterial activity of desacetylcefotaxime ( des-ctx ) , the principal metabolite of cefotaxime ( ctx ) , is eightfold lower than cefotaxime , the metabolite inhibits many b-lactamase-producing enterobacteriaceae and unusual pseudomonas species resistant to agents such as cefamandole , cefoxitin , and cefoperazone . des-ctx is more stable than ctx to attack by beta-lactamases of some species such as bacteroides fragilis , proteus vulgaris , and the k-1 enzyme of enterobacter-klebsiella . des-ctx acts synergistically with ctx against many enterobacteriaceae and streptococcus faecalis . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
13,
26
]
} | {
"id": "C0007552",
"name": "cefoperazone",
"pos": [
319,
331
]
} |
although the antibacterial activity of desacetylcefotaxime ( des-ctx ) , the principal metabolite of cefotaxime ( ctx ) , is eightfold lower than cefotaxime , the metabolite inhibits many b-lactamase-producing enterobacteriaceae and unusual pseudomonas species resistant to agents such as cefamandole , cefoxitin , and cefoperazone . des-ctx is more stable than ctx to attack by beta-lactamases of some species such as bacteroides fragilis , proteus vulgaris , and the k-1 enzyme of enterobacter-klebsiella . des-ctx acts synergistically with ctx against many enterobacteriaceae and streptococcus faecalis . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
13,
26
]
} | {
"id": "C0007554",
"name": "ctx",
"pos": [
543,
546
]
} |
the antibacterial activity of the combination of ctx/des-ctx indicates that the drug can be administered every 8-12 hr and provides excellent , broad-spectrum antimicrobial activity . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0007554",
"name": "ctx",
"pos": [
57,
60
]
} |
comparative pharmacokinetics of cefotaxime and ceftizoxime and the role of desacetylcefotaxime in the antibacterial activity of cefotaxime . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
102,
115
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
128,
138
]
} |
comparison of in vitro antibacterial activity of four oral cephems : cephalexin , cefaclor , cefatrizine and cefadroxil . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
23,
36
]
} | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
69,
79
]
} |
comparison of in vitro antibacterial activity of four oral cephems : cephalexin , cefaclor , cefatrizine and cefadroxil . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
23,
36
]
} | {
"id": "C0007537",
"name": "cefaclor",
"pos": [
82,
90
]
} |
comparison of in vitro antibacterial activity of four oral cephems : cephalexin , cefaclor , cefatrizine and cefadroxil . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
23,
36
]
} | {
"id": "C0007538",
"name": "cefadroxil",
"pos": [
109,
119
]
} |
the in vitro antibacterial activity of four oral cephems : cephalexin , cefaclor , cefatrizine and cefadroxil against clinical isolates of staphylococci , enterobacteriaceae and pseudomonas aeruginosa was compared by agar dilution method . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
13,
26
]
} | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
59,
69
]
} |
the in vitro antibacterial activity of four oral cephems : cephalexin , cefaclor , cefatrizine and cefadroxil against clinical isolates of staphylococci , enterobacteriaceae and pseudomonas aeruginosa was compared by agar dilution method . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
13,
26
]
} | {
"id": "C0007537",
"name": "cefaclor",
"pos": [
72,
80
]
} |
the in vitro antibacterial activity of four oral cephems : cephalexin , cefaclor , cefatrizine and cefadroxil against clinical isolates of staphylococci , enterobacteriaceae and pseudomonas aeruginosa was compared by agar dilution method . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
13,
26
]
} | {
"id": "C0007538",
"name": "cefadroxil",
"pos": [
99,
109
]
} |
antiepileptic drugs like carbamazepine , carbamazepine epoxide , phenytoin , valproic acid and ethosuximide do not interfere with the assay . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drugs",
"pos": [
0,
19
]
} | {
"id": "C0031507",
"name": "phenytoin",
"pos": [
65,
74
]
} |
antiepileptic drugs like carbamazepine , carbamazepine epoxide , phenytoin , valproic acid and ethosuximide do not interfere with the assay . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drugs",
"pos": [
0,
19
]
} | {
"id": "C0042291",
"name": "valproic acid",
"pos": [
77,
90
]
} |
antiepileptic drugs like carbamazepine , carbamazepine epoxide , phenytoin , valproic acid and ethosuximide do not interfere with the assay . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drugs",
"pos": [
0,
19
]
} | {
"id": "C0015043",
"name": "ethosuximide",
"pos": [
95,
107
]
} |
when compared to control animals , long-term administration of these antidepressants did not induce any alteration in the maximal number of 3h-imipramine or 3h-cyano-imipramine binding sites . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
69,
84
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
166,
176
]
} |
other neuroleptics produced effects similar to fluphenazine with their order of potency being thioridazine greater than haloperidol greater than trifluoperazine greater than fluphenazine greater than chlorpromazine . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
6,
18
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
120,
131
]
} |
from among antidepressant compounds investigated , only doxepine and amitriptyline may be regarded as antagonists of the 5-ht receptor in the rat stomach strip . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
11,
25
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
69,
82
]
} |
the antiarrhythmic and antifibrillatory actions of the beta adrenergic receptor antagonist , dl-sotalol , were examined in the canine heart subjected to myocardial ischemic injury . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
4,
18
]
} | {
"id": "C0037707",
"name": "sotalol",
"pos": [
96,
103
]
} |
we compared the activity of different antiseptics ( chlorhexidine , picloxidine dichlorhydrate , povidone-iodine , and noxythiolin ) on chlamydia trachomatis using two techniques . | therapeutic_class_of | {
"id": "C0003205",
"name": "antiseptics",
"pos": [
38,
49
]
} | {
"id": "C0032857",
"name": "povidone-iodine",
"pos": [
97,
112
]
} |
morphine produced a clear increase in locomotor activity that was reversed by the opiate receptor blocker , naloxone , and blocked by the neuroleptic , pimozide , suggesting the mediation of this effect by the ascending mesolimbic dopamine system . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
138,
149
]
} | {
"id": "C0031935",
"name": "pimozide",
"pos": [
152,
160
]
} |
the effects of the atypical neuroleptics clozapine and thioridazine and the typical neuroleptic pimozide on amphetamine-induced behavior were examined . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
28,
39
]
} | {
"id": "C0031935",
"name": "pimozide",
"pos": [
96,
104
]
} |
speed of onset of antidepressant effect was studied in 20 depressed outpatients assigned double-blind to equipotent doses of amoxapine or amitriptyline . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
18,
32
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
138,
151
]
} |
cognitive effects of brief antidepressant treatments were studied in depressed outpatients assigned double-blind to equipotent doses of amoxapine or amitriptyline in a 12-week double-crossover of 3-week periods of active agent and placebo . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
27,
41
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
149,
162
]
} |
administration of the antidepressant drugs imipramine , desmethylimipramine or tranylcypromine resulted in marked increases of both norepinephrine and dopamine concentrations while epinephrine levels were not affected . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
22,
36
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
65,
75
]
} |
administration of the antidepressant drugs imipramine , desmethylimipramine or tranylcypromine resulted in marked increases of both norepinephrine and dopamine concentrations while epinephrine levels were not affected . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
22,
36
]
} | {
"id": "C0011685",
"name": "desmethylimipramine",
"pos": [
56,
75
]
} |
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