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stringlengths 57
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dict | t
dict |
|---|---|---|---|
all 8 tested antiepileptics , namely carbamazepine , clonazepam , diazepam , diphenylhydantoin , ethosuximide , flunarizine , phenobarbital and sodium valproate decreased this behaviour in a dose-dependent way . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptics",
"pos": [
13,
27
]
} | {
"id": "C0037567",
"name": "sodium valproate",
"pos": [
144,
160
]
} |
the present study examined the effects of the neuroleptic pimozide on several measures of motor capacity and reinforcement efficacy in rats trained to respond according to a multiple random interval ( ri ) food reinforcement schedule ( mean interreinforcement intervals of 10 , 20 , 40 , 80 , and 160 sec ) . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
46,
57
]
} | {
"id": "C0031935",
"name": "pimozide",
"pos": [
58,
66
]
} |
the latter might be involved in the antidepressant effects of imipramine-like drugs in both humans and animals . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
36,
50
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
62,
72
]
} |
four antifungal agents , amphotericin b , sdz 89-485 , itraconazole , and terbinafine , were tested for efficacy in a murine model of systemic sporotrichosis . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal agents",
"pos": [
5,
22
]
} | {
"id": "C0002679",
"name": "amphotericin b",
"pos": [
25,
39
]
} |
to investigate a possible inhibitory effect of the antifungal agent ketoconazole on thyroid function , five patients with hypothyroidism and ten normal subjects were treated with ketoconazole at high doses ( 600 mg/daily in three 20-mg oral doses ) for four weeks . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal agent",
"pos": [
51,
67
]
} | {
"id": "C0022625",
"name": "ketoconazole",
"pos": [
179,
191
]
} |
[ the antimicrobial action of a complex metronidazole paste on the microbial flora in infected root canals ] . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial",
"pos": [
6,
19
]
} | {
"id": "C0025872",
"name": "metronidazole",
"pos": [
40,
53
]
} |
in vitro antibacterial activity of imipenem and other agents against gram-negative and gram-positive strains isolated from clinical specimens . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
9,
22
]
} | {
"id": "C0020933",
"name": "imipenem",
"pos": [
35,
43
]
} |
the antibacterial agents doxycycline , minocycline , ofloxacin , clindamycin , paromomycin and nifuroxazide failed to eradicate c. pylori in most patients . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial agents",
"pos": [
4,
24
]
} | {
"id": "C0008947",
"name": "clindamycin",
"pos": [
65,
76
]
} |
the antibacterial activity in vitro of imipenem ( n-formimidoyl-thienamycin ) was studied on 237 recently-isolated nosocomial bacterial strains and compared with aztreonam , cefotaxime , ceftazidime , ceftriaxone , piperacillin , amikacin and netilmicin through the determination of susceptibility by the kirby-bauer method . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0020933",
"name": "imipenem",
"pos": [
39,
47
]
} |
the antibacterial activity in vitro of imipenem ( n-formimidoyl-thienamycin ) was studied on 237 recently-isolated nosocomial bacterial strains and compared with aztreonam , cefotaxime , ceftazidime , ceftriaxone , piperacillin , amikacin and netilmicin through the determination of susceptibility by the kirby-bauer method . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0004521",
"name": "aztreonam",
"pos": [
162,
171
]
} |
the antibacterial activity in vitro of imipenem ( n-formimidoyl-thienamycin ) was studied on 237 recently-isolated nosocomial bacterial strains and compared with aztreonam , cefotaxime , ceftazidime , ceftriaxone , piperacillin , amikacin and netilmicin through the determination of susceptibility by the kirby-bauer method . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
174,
184
]
} |
the antibacterial activity in vitro of imipenem ( n-formimidoyl-thienamycin ) was studied on 237 recently-isolated nosocomial bacterial strains and compared with aztreonam , cefotaxime , ceftazidime , ceftriaxone , piperacillin , amikacin and netilmicin through the determination of susceptibility by the kirby-bauer method . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0007559",
"name": "ceftazidime",
"pos": [
187,
198
]
} |
the antibacterial activity in vitro of imipenem ( n-formimidoyl-thienamycin ) was studied on 237 recently-isolated nosocomial bacterial strains and compared with aztreonam , cefotaxime , ceftazidime , ceftriaxone , piperacillin , amikacin and netilmicin through the determination of susceptibility by the kirby-bauer method . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0007561",
"name": "ceftriaxone",
"pos": [
201,
212
]
} |
the antibacterial activity in vitro of imipenem ( n-formimidoyl-thienamycin ) was studied on 237 recently-isolated nosocomial bacterial strains and compared with aztreonam , cefotaxime , ceftazidime , ceftriaxone , piperacillin , amikacin and netilmicin through the determination of susceptibility by the kirby-bauer method . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0031955",
"name": "piperacillin",
"pos": [
215,
227
]
} |
the antibacterial activity in vitro of imipenem ( n-formimidoyl-thienamycin ) was studied on 237 recently-isolated nosocomial bacterial strains and compared with aztreonam , cefotaxime , ceftazidime , ceftriaxone , piperacillin , amikacin and netilmicin through the determination of susceptibility by the kirby-bauer method . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0002499",
"name": "amikacin",
"pos": [
230,
238
]
} |
the antibacterial activity in vitro of imipenem ( n-formimidoyl-thienamycin ) was studied on 237 recently-isolated nosocomial bacterial strains and compared with aztreonam , cefotaxime , ceftazidime , ceftriaxone , piperacillin , amikacin and netilmicin through the determination of susceptibility by the kirby-bauer method . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0027780",
"name": "netilmicin",
"pos": [
243,
253
]
} |
in a prospective study of low-dose antibacterial prophylaxis of childhood urinary tract infection ( uti ) , co-trimoxazole and trimethoprim ( tmp ) have been compared for efficacy in preventing uti , for their effect on the rectal flora and for secular selection of tmp-resistant organisms . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
35,
48
]
} | {
"id": "C0041041",
"name": "tmp",
"pos": [
266,
269
]
} |
the aim of this study was to compare the pharmacokinetics and antiarrhythmic activity of dihydroquinidine and quinidine in 14 patients ( 11 men , 3 women , aged 28 to 67 years ) with heart disease and chronic , stable , high-frequency premature ventricular beats ( pvb ) ( greater than 100/hr ) . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
62,
76
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
110,
119
]
} |
[ studies on the antibacterial activity in vitro and in vivo of ampicillin , cephaloridine , chloramphenicol and tetracycline ] . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
17,
30
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
64,
74
]
} |
[ studies on the antibacterial activity in vitro and in vivo of ampicillin , cephaloridine , chloramphenicol and tetracycline ] . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
17,
30
]
} | {
"id": "C0008168",
"name": "chloramphenicol",
"pos": [
93,
108
]
} |
the pharmacokinetics and antibacterial efficacy of mezlocillin , cefotaxime , cefoperazone and the mezlocillin/cefalosporin combinations , respectively , were studied by adopting the granuloma pouch model in rats . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
25,
38
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
65,
75
]
} |
the pharmacokinetics and antibacterial efficacy of mezlocillin , cefotaxime , cefoperazone and the mezlocillin/cefalosporin combinations , respectively , were studied by adopting the granuloma pouch model in rats . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
25,
38
]
} | {
"id": "C0007552",
"name": "cefoperazone",
"pos": [
78,
90
]
} |
antiarrhythmic efficacy and side-effects of lidocaine given in the prehospital phase of acute myocardial infarction . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
0,
14
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
44,
53
]
} |
twenty-nine cases of self-poisoning with antidepressants ( amitriptyline , imipramine , clomipramine , maprotiline , doxepine , nortriptyline , opipramol ) were examined by frequent observation of cns effects , heart rate , blood pressure and standard ecg , 24h-ecg-monitoring , measurement of systolic time intervals , eeg recordings and frequent measurement of serum levels of antidepressants and primary metabolites . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
41,
56
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
59,
72
]
} |
twenty-nine cases of self-poisoning with antidepressants ( amitriptyline , imipramine , clomipramine , maprotiline , doxepine , nortriptyline , opipramol ) were examined by frequent observation of cns effects , heart rate , blood pressure and standard ecg , 24h-ecg-monitoring , measurement of systolic time intervals , eeg recordings and frequent measurement of serum levels of antidepressants and primary metabolites . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
41,
56
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
75,
85
]
} |
twenty-nine cases of self-poisoning with antidepressants ( amitriptyline , imipramine , clomipramine , maprotiline , doxepine , nortriptyline , opipramol ) were examined by frequent observation of cns effects , heart rate , blood pressure and standard ecg , 24h-ecg-monitoring , measurement of systolic time intervals , eeg recordings and frequent measurement of serum levels of antidepressants and primary metabolites . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
41,
56
]
} | {
"id": "C0009010",
"name": "clomipramine",
"pos": [
88,
100
]
} |
twenty-nine cases of self-poisoning with antidepressants ( amitriptyline , imipramine , clomipramine , maprotiline , doxepine , nortriptyline , opipramol ) were examined by frequent observation of cns effects , heart rate , blood pressure and standard ecg , 24h-ecg-monitoring , measurement of systolic time intervals , eeg recordings and frequent measurement of serum levels of antidepressants and primary metabolites . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
41,
56
]
} | {
"id": "C0028420",
"name": "nortriptyline",
"pos": [
128,
141
]
} |
when used as a single compound , it displayed no substantial antibacterial activity but in combination with ampicillin , it was similar to clavulanic acid in conferring activity against ampicillin-resistant strains . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
61,
74
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
186,
196
]
} |
no difference was demonstrated between the two drugs in terms of their antidepressant effect , but patients treated with lofepramine suffered from significantly less side effects than patients treated with amitriptyline . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
71,
85
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
206,
219
]
} |
the value of adding a second antiepileptic drug in intractable epilepsy with complex-partial seizures was studied in a long-term prospective trial in 30 adult patients who failed to respond to the maximum use of carbamazepine , phenytoin , phenobarbital or primidone as the first drug . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drug",
"pos": [
29,
47
]
} | {
"id": "C0031507",
"name": "phenytoin",
"pos": [
228,
237
]
} |
the value of adding a second antiepileptic drug in intractable epilepsy with complex-partial seizures was studied in a long-term prospective trial in 30 adult patients who failed to respond to the maximum use of carbamazepine , phenytoin , phenobarbital or primidone as the first drug . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drug",
"pos": [
29,
47
]
} | {
"id": "C0033148",
"name": "primidone",
"pos": [
257,
266
]
} |
based on the individual previous history of one-drug treatment , the most promising antiepileptic drug ( carbamazepine , clobazam , clonazepam , phenobarbital , phenytoin , primidone , valproic acid ) was added , if necessary until clinical toxicity occurred . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drug",
"pos": [
84,
102
]
} | {
"id": "C0031507",
"name": "phenytoin",
"pos": [
161,
170
]
} |
based on the individual previous history of one-drug treatment , the most promising antiepileptic drug ( carbamazepine , clobazam , clonazepam , phenobarbital , phenytoin , primidone , valproic acid ) was added , if necessary until clinical toxicity occurred . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drug",
"pos": [
84,
102
]
} | {
"id": "C0033148",
"name": "primidone",
"pos": [
173,
182
]
} |
based on the individual previous history of one-drug treatment , the most promising antiepileptic drug ( carbamazepine , clobazam , clonazepam , phenobarbital , phenytoin , primidone , valproic acid ) was added , if necessary until clinical toxicity occurred . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drug",
"pos": [
84,
102
]
} | {
"id": "C0042291",
"name": "valproic acid",
"pos": [
185,
198
]
} |
the in vitro effects of 3 antimalarial compounds ( chloroquine , quinacrine and quinidine ) on 3 components of the autonomic nervous system have been investigated . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial",
"pos": [
26,
38
]
} | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
51,
62
]
} |
all three neuroleptics produced a dose-dependent inhibition of the binding with inhibition constants of 33.7 , 89.6 , and 34.2 microm for haloperidol , chlorpromazine , and clozapine , respectively , and resulted in parabolic hill plots suggestive of multiprocess modes of action rather than simple competitive or noncompetitive interactions . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
10,
22
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
138,
149
]
} |
fouriezos and co-workers have reported that rats treated with the neuroleptics , pimozide or d-butaclamol , barpress at baseline rates at the start of an intracranial self-stimulation ( icss ) session , but cease responding within a few minutes . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
66,
78
]
} | {
"id": "C0031935",
"name": "pimozide",
"pos": [
81,
89
]
} |
the antiarrhythmic effect of disopyramide retard ( dr ) in a dose of 2 x 300 mg/day , propranolol retard ( pr ) in one of 1 x 160 mg/day and placebo was compared in a randomized crossover study in patients with ventricular premature beats ( vpb ) . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
4,
18
]
} | {
"id": "C0012702",
"name": "disopyramide",
"pos": [
29,
41
]
} |
these results suggest that the antiarrhythmic effect of disopyramide in slow release preparations is comparable with that of disopyramide in standard capsule formulation given in the usual and more complicated regime with four divided doses . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
31,
45
]
} | {
"id": "C0012702",
"name": "disopyramide",
"pos": [
125,
137
]
} |
the analogue exhibited less cardiac depressant action on left ventricular rate ( dp/dt ) and force of contraction than lignocaine . | therapeutic_class_of | {
"id": "C0003195",
"name": "cardiac depressant",
"pos": [
28,
46
]
} | {
"id": "C0023660",
"name": "lignocaine",
"pos": [
119,
129
]
} |
these results clearly indicates that the lipid bilayer membrane is more permeable to ampicillin than cefazolin and cephaloridine , and they are consistent with the observations of sawai et al. , who showed that ampicillin was a more effective antibacterial drug than cefazolin and cephaloridine against the porin-deficient mutants . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial drug",
"pos": [
243,
261
]
} | {
"id": "C0007546",
"name": "cefazolin",
"pos": [
267,
276
]
} |
[ comparative evaluation of the antibacterial activity of cefotaxime and cephalotin by using an automated antimicrobial susceptibility determination system ] . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
32,
45
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
58,
68
]
} |
in this study we have evaluated the antibacterial activity of cefotaxime comparatively with the activity of cephalotin against 66 gram-negative bacteria and 31 gram-positive bacteria by using an automated antimicrobial susceptibility determination system . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
36,
49
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
62,
72
]
} |
the mechanisms by which clavulanic acid inhibits beta-lactamases and potentiates the antibacterial action of amoxycillin are discussed . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
85,
98
]
} | {
"id": "C0002645",
"name": "amoxycillin",
"pos": [
109,
120
]
} |
our previously described hplc method for the simultaneous analysis of several antiarrhythmic drugs and metabolites in serum [ clin . biochem . 14 . 113-118 ( 1981 ) ] was correlated with an enzyme immunoassay technique ( emit ) for quinidine , procainamide , n-acetyl procainamide , and disopyramide . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drugs",
"pos": [
78,
98
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
232,
241
]
} |
our previously described hplc method for the simultaneous analysis of several antiarrhythmic drugs and metabolites in serum [ clin . biochem . 14 . 113-118 ( 1981 ) ] was correlated with an enzyme immunoassay technique ( emit ) for quinidine , procainamide , n-acetyl procainamide , and disopyramide . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drugs",
"pos": [
78,
98
]
} | {
"id": "C0033216",
"name": "procainamide",
"pos": [
268,
280
]
} |
our previously described hplc method for the simultaneous analysis of several antiarrhythmic drugs and metabolites in serum [ clin . biochem . 14 . 113-118 ( 1981 ) ] was correlated with an enzyme immunoassay technique ( emit ) for quinidine , procainamide , n-acetyl procainamide , and disopyramide . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drugs",
"pos": [
78,
98
]
} | {
"id": "C0012702",
"name": "disopyramide",
"pos": [
287,
299
]
} |
human skin fibroblasts and amniotic fluid cells showed sensitivity to antifungal agents in the order econazole less than pimafucin less than fungizone , with the last initially reducing cell growth 10-20 % , even at the level recommended for cell culture . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
70,
80
]
} | {
"id": "C0013547",
"name": "econazole",
"pos": [
101,
110
]
} |
it is proposed that inhibition of endogenous lipolysis may be the main mechanism of action of antiarrhythmic agents ( lidocaine , quinidine , phenothiazines ) . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agents",
"pos": [
94,
115
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
118,
127
]
} |
it is proposed that inhibition of endogenous lipolysis may be the main mechanism of action of antiarrhythmic agents ( lidocaine , quinidine , phenothiazines ) . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agents",
"pos": [
94,
115
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
130,
139
]
} |
[ antibacterial effect of n-formimidoyl-thienamycin in combination with amikacin , cefoxitin and fosfomycin on k. pneumoniae and p. aeruginosa ] . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
2,
15
]
} | {
"id": "C0002499",
"name": "amikacin",
"pos": [
72,
80
]
} |
[ antibacterial effect of n-formimidoyl-thienamycin in combination with amikacin , cefoxitin and fosfomycin on k. pneumoniae and p. aeruginosa ] . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
2,
15
]
} | {
"id": "C0007557",
"name": "cefoxitin",
"pos": [
83,
92
]
} |
from this a differential therapy treating patients suffering from paranoid-hallucinatory symptoms with neuroleptics ( e.g . haloperidol ) can be deduced , while the danger of grand-mal seizures has to be considered when disorders of consciousness appear . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
103,
115
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
124,
135
]
} |
[ effect of antiepileptic treatment with phenobarbital and phenytoin on various parameters of immunity . comparative study ] . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic",
"pos": [
12,
25
]
} | {
"id": "C0031507",
"name": "phenytoin",
"pos": [
59,
68
]
} |
since haloperidol does not block beta-adrenergic receptors and the ophthalmic dose required to lower iop is only 6.5 % of the antipsychotic dose , haloperidol might be a good drug for glaucoma treatment with the possibility of minimal side effects . | therapeutic_class_of | {
"id": "C0040615",
"name": "antipsychotic",
"pos": [
126,
139
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
147,
158
]
} |
the accumulation of the antimalarial drug mefloquine by human red blood cells has been studied by 19f-nmr spectroscopy . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial",
"pos": [
24,
36
]
} | {
"id": "C0025153",
"name": "mefloquine",
"pos": [
42,
52
]
} |
when the susceptibility of the 25 isolates to other commonly used antibacterials was tested , 18 isolates of h influenzae were resistant to erythromycin and one was resistant to ampicillin . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterials",
"pos": [
66,
80
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
178,
188
]
} |
a total of 370 patients were subjected to a comprehensive international examination ( within the frameworks of the who ) by the double blind method for the efficacy of low ( 75 mg/day ) and high ( 150 mg/day ) doses of antidepressants ( maprotiline , amitriptyline , imipramine ) . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
219,
234
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
251,
264
]
} |
a total of 370 patients were subjected to a comprehensive international examination ( within the frameworks of the who ) by the double blind method for the efficacy of low ( 75 mg/day ) and high ( 150 mg/day ) doses of antidepressants ( maprotiline , amitriptyline , imipramine ) . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
219,
234
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
267,
277
]
} |
benzoate ( iv e ) showed a remarkable hypotensive and bradycardic activity in rats , whereas acetate ( iv a ) showed infiltration anesthesia and antiarrhythmic activity in mice slightly inferior to those of lidocaine . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
145,
159
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
207,
216
]
} |
cefotetan was found to give much higher pouch exudate concentrations than cefmetazole , and to show prolonged antibacterial levels even when compared with cefazolin . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
110,
123
]
} | {
"id": "C0007546",
"name": "cefazolin",
"pos": [
155,
164
]
} |
electrophysiologic and hemodynamic studies were performed before and after intravenous infusion of a new antiarrhythmic agent , propafenone , in 28 patients with recurrent ventricular tachycardia . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agent",
"pos": [
105,
125
]
} | {
"id": "C0033429",
"name": "propafenone",
"pos": [
128,
139
]
} |
all had failed to respond to conventional antiarrhythmic therapy and were therefore treated with oral amiodarone ( 1,600 to 2,000 mg/day for 2 weeks , then 800 to 1,200 mg/day for another 2 weeks with subsequent 200 to 600 mg/day maintenance doses ) . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
42,
56
]
} | {
"id": "C0002598",
"name": "amiodarone",
"pos": [
102,
112
]
} |
during treatment with antimicrobial drugs an increase in the excretion of fecal conjugated and , with the exception of the oxytetracycline experiments , also of unconjugated estrogens paralleled a decrease in urinary estrogen excretion , especially for e2 and e3 . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial",
"pos": [
22,
35
]
} | {
"id": "C0030092",
"name": "oxytetracycline",
"pos": [
123,
138
]
} |
antiarrhythmic effects of mexiletine were examined using three canine ventricular arrhythmia models -- digitalis- , adrenaline- , and two-stage coronary ligation-induced arrhythmias . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
0,
14
]
} | {
"id": "C0025887",
"name": "mexiletine",
"pos": [
26,
36
]
} |
the correlations between the mexiletine plasma concentrations and its antiarrhythmic effects were not very strong , probably indicating individual variations in sensitivity to mexiletine . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
70,
84
]
} | {
"id": "C0025887",
"name": "mexiletine",
"pos": [
176,
186
]
} |
twenty-six patients with cysticercosis of the brain parenchyma were treated with the antihelmintic agent praziquantel ( 50 mg per kilogram of body weight daily for 15 days ) . | therapeutic_class_of | {
"id": "C0003158",
"name": "antihelmintic agent",
"pos": [
85,
104
]
} | {
"id": "C0032911",
"name": "praziquantel",
"pos": [
105,
117
]
} |
the convulsant effects of tmsm include a blockade of postsynaptic gaba actions , but the antiepileptic effects of esm are not due to an enhancement of gaba-mediated inhibition . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic",
"pos": [
89,
102
]
} | {
"id": "C0015043",
"name": "esm",
"pos": [
114,
117
]
} |
urine iodide excretion was also examined in a group of 28 patients attending a thyroid clinic , with thyroid disease of diverse aetiology and in 34 patients taking the antiarrhythmic drug amiodarone for control of cardiac arrhythmias . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
168,
182
]
} | {
"id": "C0002598",
"name": "amiodarone",
"pos": [
188,
198
]
} |
anthelmintic effect of levamisole , ivermectin , albendazole and fenbendazole on larval toxocara canis infection in mice . | therapeutic_class_of | {
"id": "C0003158",
"name": "anthelmintic",
"pos": [
0,
12
]
} | {
"id": "C0001911",
"name": "albendazole",
"pos": [
49,
60
]
} |
the anthelmintic effects of levamisole ( 100-50 mg kg-1 live bodyweight ) , ivermectin ( 2 mg kg-1 bodyweight ) , albendazole and fenbendazole ( both 100 mg kg-1 bodyweight ) , were tested against second stage toxocara canis larvae in mice . | therapeutic_class_of | {
"id": "C0003158",
"name": "anthelmintic",
"pos": [
4,
16
]
} | {
"id": "C0001911",
"name": "albendazole",
"pos": [
114,
125
]
} |
to evaluate the effects of the 3 commonly used antiarrhythmic agents -- disopyramide , procainamide and quinidine -- on left ventricular ( lv ) function , these 3 agents were administered in random sequence after control radionuclide angiography performed at rest and during exercise in 17 patients . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
47,
61
]
} | {
"id": "C0012702",
"name": "disopyramide",
"pos": [
72,
84
]
} |
to evaluate the effects of the 3 commonly used antiarrhythmic agents -- disopyramide , procainamide and quinidine -- on left ventricular ( lv ) function , these 3 agents were administered in random sequence after control radionuclide angiography performed at rest and during exercise in 17 patients . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
47,
61
]
} | {
"id": "C0033216",
"name": "procainamide",
"pos": [
87,
99
]
} |
to evaluate the effects of the 3 commonly used antiarrhythmic agents -- disopyramide , procainamide and quinidine -- on left ventricular ( lv ) function , these 3 agents were administered in random sequence after control radionuclide angiography performed at rest and during exercise in 17 patients . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
47,
61
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
104,
113
]
} |
the long-acting antirheumatic drug d-penicillamine was found to inhibit the growth of asynchronous cultures of rabbit articular chondrocytes . | therapeutic_class_of | {
"id": "C0003191",
"name": "antirheumatic drug",
"pos": [
16,
34
]
} | {
"id": "C0030817",
"name": "penicillamine",
"pos": [
37,
50
]
} |
the antimicrobial combinations were penicillin and clavulanic acid , penicillin and gentamicin , and metronidazole and gentamicin . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial",
"pos": [
4,
17
]
} | {
"id": "C0025872",
"name": "metronidazole",
"pos": [
101,
114
]
} |
amiodarone has also been shown to interact with other antiarrhythmic agents such as quinidine and procainamide . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agents",
"pos": [
54,
75
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
84,
93
]
} |
amiodarone has also been shown to interact with other antiarrhythmic agents such as quinidine and procainamide . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agents",
"pos": [
54,
75
]
} | {
"id": "C0033216",
"name": "procainamide",
"pos": [
98,
110
]
} |
[ antiarrhythmic efficacy of mexiletine in supraventricular arrhythmias , wolff-parkinson-white syndrome and persistent iterative ventricular hyperkinetic arrhythmias . considerations on these less noted therapeutic effects ] . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
2,
16
]
} | {
"id": "C0025887",
"name": "mexiletine",
"pos": [
29,
39
]
} |
the in vitro activity of norfloxacin ( mk-0366 ) , a new oral antimicrobial agent , was compared to that of ampicillin , tetracycline , cefazolin , nitrofurantoin , nalidixic acid , and trimethoprim against 199 gram-negative urinary isolates . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial agent",
"pos": [
62,
81
]
} | {
"id": "C0039644",
"name": "tetracycline",
"pos": [
121,
133
]
} |
on the contrary , the interaction of neuroleptics ( d-butaclamol and haloperidol ) and dopamine agonists ( apomorphine and bromocriptine ) was unaffected by the nacl conditions . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
37,
49
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
69,
80
]
} |
nomifensine , a tetrahydroisoquinoline antidepressant , was compared with imipramine in a 4-week multicenter double-blind study of depressed outpatients ( 100 on nomifensine , 56 on imipramine ) . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
39,
53
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
182,
192
]
} |
effect of aging on hypothalamic lh-releasing and prolactin inhibiting activities and pituitary responsiveness to lhrh in the male laboratory rat . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
19,
31
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
113,
117
]
} |
hypothalamic content of lh releasing and prolactin inhibiting activities and pituitary responsiveness to lh releasing hormone was measured in young ( 4 mo . ) and aged ( 26 mo . ) | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
0,
12
]
} | {
"id": "C0023610",
"name": "lh releasing hormone",
"pos": [
105,
125
]
} |
erthrocytes containing 43 percent introduced hemoglobin c developed all of the morphologic alterations associated with intra-erythrocytic hemoglobin c , including hemoglobin aggregation , targetting , and intracellular crystallization , after inclbation for 24 hours in isotonic saline : dithionite . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocytic",
"pos": [
125,
137
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
163,
173
]
} |
the results support the concept that the sickling process , and morphologic erythrocyte alterations occurring in hemoglobin c disorders are primary to the respective hemoglobins rather than the membrane . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
76,
87
]
} | {
"id": "C0019046",
"name": "hemoglobins",
"pos": [
166,
177
]
} |
in the days following exposure to hypothalamic or peripheral implantation of t , however , a progressively developing decline in the response to exogenous lhrh was observed . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
34,
46
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
155,
159
]
} |
since thyroglobulin purified from normal human thyroid glands and the purified retro-orbital tissue preparation are nearly equivalent as antigens in the mif assay of exophthalmic patients , we conclude that thyroglobulin or an antigenic component of the thyroglobulin molecule is one of the antigens to which patients with graves ' disease and exophthalmos demonstrate delayed hypersensitivity . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid glands",
"pos": [
47,
61
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
254,
267
]
} |
it is concluded that in screening large numbers of persons at risk for thyroid neoplasia , thyroglobulin assays are useful in combination with other modes of evaluation . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
71,
78
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
91,
104
]
} |
in contrast to the erythrocytosis induced by ir injection of ni3s2 , administration of ni3s2 by intramuscular ( im ) injection ( 10 mg per rat ) had no significant effect upon blood pcv , rbc or hemoglobin values or upon morphology of bone marrow . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "rbc",
"pos": [
188,
191
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
195,
205
]
} |
free erythrocyte porphyrin : hemoglobin ratios , serum ferritin , and transferrin saturation levels during treatment of infants with iron-deficiency anemia . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
5,
16
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
29,
39
]
} |
in adult hypothalamic homogenates , trh and lhrh were associated with two populations of particles distinguishable by their sedimentation properties . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
9,
21
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
44,
48
]
} |
however , in hypothalami of 14-day-old males and 21-day-old females , association of lhrh with the subpopulation of small particles was evident . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalami",
"pos": [
13,
24
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
85,
89
]
} |
it is concluded that 1 ) the nature of the hypothalamic subcellular compartmentalization of trh and lhrh is age dependent , 2 ) the compartmentalization of each peptide in neonatal hypothalami differs from that in the adults , and 3 ) the development of the mature profile of subcellular compartmentalization of trh and lhrh proceeds asynchronously . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalami",
"pos": [
43,
54
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
320,
324
]
} |
in order to study the effect of marked chylomicronemia on red cell oxygen release , oxygen hemoglobin dissociation curves ( odc 's ) from zero to full saturation were determined on whole blood from three siblings with familial type i hyperlipoproteinemia . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cell",
"pos": [
58,
66
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
91,
101
]
} |
guanosine triphosphate ( gtp ) , the major erythrocytic organic phosphate , however , depresses the oxygen affinity of the composite and separated hemoglobins more effectively than atp suggesting that gtp is the primary modulator of oxygen affinity . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocytic",
"pos": [
43,
55
]
} | {
"id": "C0019046",
"name": "hemoglobins",
"pos": [
147,
158
]
} |
the thymus gland : recent studies relating to 'thymosin ' , ageing and 'slow ' infection of the nervous system . | tissue_is_expression_site_of_gene_product | {
"id": "C0040113",
"name": "thymus gland",
"pos": [
4,
16
]
} | {
"id": "C0040106",
"name": "thymosin",
"pos": [
47,
55
]
} |
there was a significant fall in total erythrocyte ( rbc ) and total leucocyte ( wbc ) counts and haemoglobin content ( hb ) was reduced . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "rbc",
"pos": [
52,
55
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
119,
121
]
} |
additionally , erythrocyte 2,3-diphosphoglycerate ( dpg ) values were measured , and oxygen tension ( mm of hg ) when hemoglobin is half-saturated with oxygen ( p50 ) values were calculated . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
15,
26
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
118,
128
]
} |
number of -sh groups in red cell hemolysates amounts to 8 per mole hb ( 7,88 - 8,48 ) , logp50=1,04-0,94 ; | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cell",
"pos": [
24,
32
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
67,
69
]
} |
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