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a study was made of the enzymes of the islands of langerhans which could participate in the transformation of proinsulin into insulin . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "of",
"pos": [
17,
19
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
126,
133
]
} |
[ effects of intraventriculary injected prolactin on hypothalamic lh-rh neurons in male guinea pig . immunocytological study ( author 's transl ) ( proceedings ) ] . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
53,
65
]
} | {
"id": "C0023610",
"name": "lh-rh",
"pos": [
66,
71
]
} |
there is evidence from thymic grafts that a hypothetical factor , thymopoietin , may stimulate mitosis of thymic lymphocytes . | tissue_is_expression_site_of_gene_product | {
"id": "C0040113",
"name": "thymic",
"pos": [
23,
29
]
} | {
"id": "C0040105",
"name": "thymopoietin",
"pos": [
66,
78
]
} |
[ identification by immunofluorescence of various categories of anterior pituitary gland cells ( somatotropin , prolactin , corticotropin , melanotropin , gonadotropin , and thyrotropin cells ) in the spermophile ( citellus variegatus ) ] . | tissue_is_expression_site_of_gene_product | {
"id": "C0032008",
"name": "anterior",
"pos": [
64,
72
]
} | {
"id": "C0033371",
"name": "prolactin",
"pos": [
112,
121
]
} |
[ identification by immunofluorescence of various categories of anterior pituitary gland cells ( somatotropin , prolactin , corticotropin , melanotropin , gonadotropin , and thyrotropin cells ) in the spermophile ( citellus variegatus ) ] . | tissue_is_expression_site_of_gene_product | {
"id": "C0032008",
"name": "anterior",
"pos": [
64,
72
]
} | {
"id": "C0040160",
"name": "thyrotropin",
"pos": [
174,
185
]
} |
the oxygen supply to the tissues is maintained by a compensatory rise in cardiac output and o2-extraction , mainly from the remaining red cell hemoglobin . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cell",
"pos": [
134,
142
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
143,
153
]
} |
these studies show 1 ) no definitive cause and effect relationship of the increments in mbh lhrh either with lh release ( or lhrh release ) or with changes in hypothalamic catecholamines induced by p treatment , and 2 ) that the striking rise in the mbh lhrh levels in estradiol benzoate-primed rats may represent formation of new immunoreactive lhrh predominantly in the median eminence region . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
159,
171
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
346,
350
]
} |
we suggest that this effect is mediated through a self-priming effect of gnrh and that this in vitro technique may be used to detect hypothalamic release of gnrh . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
133,
145
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
157,
161
]
} |
heterotransplantation of several long-term rat liver cell lines into nude mice and subsequent re-establishment in vitro resulted in the derivation of hepatocyte cultures expressing both alpha-fetoprotein and albumin . | tissue_is_expression_site_of_gene_product | {
"id": "C0023884",
"name": "liver",
"pos": [
47,
52
]
} | {
"id": "C0002210",
"name": "alpha-fetoprotein",
"pos": [
186,
203
]
} |
isolated islets of langerhans of ordinary size from the pancreas of tumor-bearing rats , on the other hand , usually exhibited a normal ( biphasic ) iri release pattern in response to glucose . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "islets of langerhans",
"pos": [
9,
29
]
} | {
"id": "C0021641",
"name": "iri",
"pos": [
149,
152
]
} |
the hmw hb contributes to the inhibition of sickling resulting from treatment of sickle erythrocyte with mai by increasing both mgc and oxygen affinity of the modified hb . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
88,
99
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
168,
170
]
} |
postsynaptic alpha-2 adrenergic receptors in isolated rat islets of langerhans : inhibition of insulin release and cyclic 3':5'-adenosine monophosphate accumulation . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "islets of langerhans",
"pos": [
58,
78
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
95,
102
]
} |
seven biochemical blood parameters , including glutathione , red blood cell glutathione reductase , 2,3-diphosphoglycerate , methemoglobin , vitamin e , complement c2 , and iga were measured prior to exposure , immediately after exposure , and 22 hr following exposure . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red blood cell",
"pos": [
61,
75
]
} | {
"id": "C0025635",
"name": "methemoglobin",
"pos": [
125,
138
]
} |
both histone acetylation and deacetylation in nuclei from hepatoma cells ( ah 66 cells ) occurred two times faster than those of nuclei from fetal and adult livers regardless of alpha-fetoprotein production . | tissue_is_expression_site_of_gene_product | {
"id": "C0023884",
"name": "livers",
"pos": [
157,
163
]
} | {
"id": "C0002210",
"name": "alpha-fetoprotein",
"pos": [
178,
195
]
} |
the data further demonstrate a hypothalamic mechanism in the mel by which hyperprolactinemia could inhibit lhrh release . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
31,
43
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
107,
111
]
} |
these results suggest a release of hypothalamic somatostatin into the hypophysial portal blood in response to intraventricular administration of neurotensin , probably by a histaminergic mechanism . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
35,
47
]
} | {
"id": "C0037659",
"name": "somatostatin",
"pos": [
48,
60
]
} |
we therefore propose that rat hypothalamic somatostatin-14 is identical in structure to somatostatin-14 found in other species . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
30,
42
]
} | {
"id": "C0037659",
"name": "somatostatin-14",
"pos": [
88,
103
]
} |
influence of cadmium , lead , and zinc on the ability of sensitized guinea pig lymphocytes to interact with specific antigen and to produce lymphokine . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocytes",
"pos": [
79,
90
]
} | {
"id": "C0024297",
"name": "lymphokine",
"pos": [
140,
150
]
} |
this shows that there is no obligatory correlation between t cell function and antigen recognition and may suggest that the t cell receptor repertoire is biased towards recognizing private specificities . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cell",
"pos": [
59,
65
]
} | {
"id": "C0034790",
"name": "t cell receptor",
"pos": [
124,
139
]
} |
results from its use support an explanation for human tuberculoimmunity that is like that for mouse tuberculoimmunity : that immune lymphocytes are stimulated by being cultured with immunizing antigen to make a lymphokine which enables syngeneic macrophages to kill intracellular tubercle bacilli . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocytes",
"pos": [
132,
143
]
} | {
"id": "C0024297",
"name": "lymphokine",
"pos": [
211,
221
]
} |
these cells are cultured separately , the lymphocytes for 72 h with antigen to make immune lymphokine and the monocytes for 7 days to become macrophages . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocytes",
"pos": [
42,
53
]
} | {
"id": "C0024297",
"name": "lymphokine",
"pos": [
91,
101
]
} |
infusion of 20 or 202 microgram corticosterone over 6 h significantly reduced hypothalamic crf ( corticotropin-releasing factor ) content , whereas it did not reduce plasma acth levels in normal rats . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
78,
90
]
} | {
"id": "C0010132",
"name": "corticotropin-releasing factor",
"pos": [
97,
127
]
} |
predominance of t-lymphocytes with a high-affinity receptor for sheep red blood cells in the synovial fluid of patients with rheumatoid arthritis . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t-lymphocytes",
"pos": [
16,
29
]
} | {
"id": "C0108773",
"name": "receptor",
"pos": [
51,
59
]
} |
this study was carried out to search for possible association between some polymorphic systems including abo , mnss , rh , duffy , kell , kidd , haptoglobin ( hp ) and red cell acid phosphatase ( phs ) , and the variables serum cholesterol , triglyceride , urate , haemoglobin and blood pressure , in two separate samples of the australian white population . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cell",
"pos": [
168,
176
]
} | {
"id": "C0019046",
"name": "haemoglobin",
"pos": [
265,
276
]
} |
trypsin cleaved the somatostatin ( ss ) entity less selectively from ovine hypothalamic ss-28 than from rat hypothalamic 12 000-dalton ss-like polypeptide ( 12k ss ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
75,
87
]
} | {
"id": "C0037659",
"name": "ss",
"pos": [
161,
163
]
} |
a light microscopic immunocytochemical study of the brain of frogs with hypothalamic lesions was performed in order to obtain evidence concerning the origin of somatostatin fibers in the median eminence and neural lobe of the hypophysis . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
72,
84
]
} | {
"id": "C0037659",
"name": "somatostatin",
"pos": [
160,
172
]
} |
this control is most likely to be at the level of the hypothalamus , and involves modulation of pulsatile lhrh release . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
54,
66
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
106,
110
]
} |
negative feedback effects of progesterone correlated with changes in hypothalamic norepinephrine and dopamine turnover rates , median eminence luteinizing hormone-releasing hormone , and peripheral plasma gonadotropins . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
69,
81
]
} | {
"id": "C0023610",
"name": "luteinizing hormone-releasing hormone",
"pos": [
143,
180
]
} |
on a larger scale , an extract of hypothalamic tissue from sheep was used to establish a multi-stage isolation procedure that resulted in a 200000-fold purification of luteinizing-hormone-releasing factor . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
34,
46
]
} | {
"id": "C0023610",
"name": "luteinizing-hormone-releasing factor",
"pos": [
168,
204
]
} |
the authors determined mean day-to-day ( daily over five days ) , mean week-to-week ( weekly over five weeks ) and mean hour-to-hour ( 800 h , 1100 h , 1400 h ) physiologic intra-individual variation of concentration values of leukocyte cell types , platelet count , and erythrocyte values ( hematocrit , hemoglobin ) for a group of 20 healthy adult volunteers . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
271,
282
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
305,
315
]
} |
these studies establish that the placenta contains large amounts of lrf , immunologically identical to hypothalamic lrf . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
103,
115
]
} | {
"id": "C0023610",
"name": "lrf",
"pos": [
116,
119
]
} |
isolated pancreatic islets releasing insulin in response to glucose stimulation have been used as a specific example . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "pancreatic islets",
"pos": [
9,
26
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
37,
44
]
} |
the effect on spleen colony formation caused by the transplantation of untreated lymphocytes , as well as of lymphocytes previously incubated with pha , or with pha plus l-asparaginase , or with lymphokines , was studied . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocytes",
"pos": [
81,
92
]
} | {
"id": "C0024297",
"name": "lymphokines",
"pos": [
195,
206
]
} |
another possible explanation is that cfus division , or their spleen take is enhanced by the immunocompetent lymphocytes activated by pha , either directly or via soluble mediators produced or released by immunocompetent lymphocytes such as lymphokines . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocytes",
"pos": [
109,
120
]
} | {
"id": "C0024297",
"name": "lymphokines",
"pos": [
241,
252
]
} |
purified human liver cathepsin b digested fetuin to about 3 % of total hydrolysis and the major peptide fragment produced had an sds-electrophoretic mobility equivalent to that of ovalbumin . | tissue_is_expression_site_of_gene_product | {
"id": "C0023884",
"name": "liver",
"pos": [
15,
20
]
} | {
"id": "C0002210",
"name": "fetuin",
"pos": [
42,
48
]
} |
of the agents in the hypothalamus that stimulate prolactin release , the most important appear to be an as yet uncharacterized polypeptide prolactin releasing factor ( prf ) , thyrotropin releasing hormone ( trh ) and serotonin . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
21,
33
]
} | {
"id": "C0023610",
"name": "prolactin releasing factor",
"pos": [
139,
165
]
} |
it probably alters hypothalamic neurotransmitter content through a direct feedback mechanism resulting in a decrease of gn-rh . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
19,
31
]
} | {
"id": "C0023610",
"name": "gn-rh",
"pos": [
120,
125
]
} |
a derivative of the hypothalamic peptide luteinizing hormone-releasing hormone ( lhrh ) has been coupled to ferritin and the conjugate purified by gel chromatography . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
20,
32
]
} | {
"id": "C0023610",
"name": "luteinizing hormone-releasing hormone",
"pos": [
41,
78
]
} |
the series of red blood cells staining with erythrosin b correspond to the primary erythrocyte series suggesting that hemoglobin expression during development is correlated with different cell populations . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
83,
94
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
118,
128
]
} |
it is concluded that a synaptosome-enriched fraction from the hypothalamus contains readily releasable pools of lhrh and trh which are mobilized rapidly by depolarizing concentrations of k+ in a ca++-dependent manner . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
62,
74
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
112,
116
]
} |
in contrast , this mrna was greatly depleted in total rna from yolk sac mesoderm and essentially absent in brain , adult liver , and a non-alpha-fetoprotein-producing hepatoma . | tissue_is_expression_site_of_gene_product | {
"id": "C0023884",
"name": "liver",
"pos": [
121,
126
]
} | {
"id": "C0002210",
"name": "alpha-fetoprotein",
"pos": [
139,
156
]
} |
effect of copulation on the hypothalamic content of gonadotrophic hormone-releasing hormone in the vole , microtus agrestis . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
28,
40
]
} | {
"id": "C0023610",
"name": "gonadotrophic",
"pos": [
52,
65
]
} |
there was a drop of 56 % in the hypothalamic content of gn-rh in female voles 5 min after mating compared with that in unmated but receptive animals . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
32,
44
]
} | {
"id": "C0023610",
"name": "gn-rh",
"pos": [
56,
61
]
} |
slight decrease of rbc , ht , hb and platelet , and increase of reticulocytes were noted in the 400 mg/kg group . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "rbc",
"pos": [
19,
22
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
30,
32
]
} |
vitamin k is required for the posttranslational modification of liver precursors of prothrombin , blood coagulation factors vii , ix , and x and additional proteins of undetermined functions in plasma and other tissues . | tissue_is_expression_site_of_gene_product | {
"id": "C0023884",
"name": "liver",
"pos": [
64,
69
]
} | {
"id": "C0015502",
"name": "blood coagulation factors vii",
"pos": [
98,
127
]
} |
it is possible , however , that cysteamine acts also at the hypothalamus to reduce lhrh secretion and/or at the testes to reduce testosterone release . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
60,
72
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
83,
87
]
} |
processing of synthetic somatostatin-28 and a related endogenous rat hypothalamic somatostatin-like molecule by hypothalamic enzymes . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
69,
81
]
} | {
"id": "C0037659",
"name": "somatostatin",
"pos": [
82,
94
]
} |
synthetic somatostatin-28 ( s-28 ) as well as a related endogenous rat hypothalamic somatostatin-like compound ( 3k sli ) were incubated with hypothalamic extracts from which endogenous somatostatin-like immunoreactivity ( sli ) had been removed by immunoabsorption . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
71,
83
]
} | {
"id": "C0037659",
"name": "somatostatin",
"pos": [
186,
198
]
} |
hypothalamic somatostatin content in both rostral and caudal areas was lower in old than in young rats ( p less than 0.01 ) , and l-dopa had no significant effect on somatostatin content . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
0,
12
]
} | {
"id": "C0037659",
"name": "somatostatin",
"pos": [
166,
178
]
} |
the decrease of hypothalamic lhrh in castrated rats was completely blocked by testosterone propionate or morphine sulfate administration . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
16,
28
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
29,
33
]
} |
the protease-treated platelets lose their ability to aggregate with bovine von willebrand factor and human von willebrand factor plus ristocetin . | tissue_is_expression_site_of_gene_product | {
"id": "C0005821",
"name": "platelets",
"pos": [
21,
30
]
} | {
"id": "C0795677",
"name": "human von",
"pos": [
101,
110
]
} |
furthermore , with the possible exception of myosin heavy chain , the contractile protein genes expressed by cultured embryogenic muscle encode adult muscle proteins of both basal and slow fiber types , consistent with a co-activation-selective repression model of gene regulation during fiber type differentiation in developing skeletal muscle . | tissue_is_expression_site_of_gene_product | {
"id": "C0026845",
"name": "muscle",
"pos": [
130,
136
]
} | {
"id": "C0026832",
"name": "muscle proteins",
"pos": [
150,
165
]
} |
however , the study with the rat langerhans islets in vitro indicated a great difference in mode of stimulation of insulin release between dg-5128 and a sulphonylurea hypoglycaemic , tolbutamide . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "langerhans islets",
"pos": [
33,
50
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
115,
122
]
} |
immunofluorescence studies showed that the cells contain at least two antigenically different types of filaments , actin and keratin , and that the cells produce true basement membrane ( collagen iv ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membrane",
"pos": [
167,
184
]
} | {
"id": "C0009333",
"name": "collagen iv",
"pos": [
187,
198
]
} |
to estimate the relative participation of transported and intrathyroidally generated iodide ( internal iodide ) in the iodination of newly synthesized and preexisting thyroglobulin ( tg ) in the rat thyroid , the specific radioactivities ( sras ) of thyroid iodide , tg , lysosomal iodine , and plasma hormones were followed for 92 h after radioactive iodide injection in intact or hypophysectomized rats . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
63,
70
]
} | {
"id": "C0040123",
"name": "tg",
"pos": [
267,
269
]
} |
this effect was observed with 3 anti-cea sera in 3 cancer patients ( colon cancer , stomach cancer , teratocarcinoma ) , who 's lymphocytes responded to cea by lymphokine release . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocytes",
"pos": [
128,
139
]
} | {
"id": "C0024297",
"name": "lymphokine",
"pos": [
160,
170
]
} |
homologous rbc were treated with 20 mm phenylhydrazine hydrochloride in vitro and injected into rats at doses of 5 , 15 , 75 , and 150 mg of hemoglobin per 100 g . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "rbc",
"pos": [
11,
14
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
141,
151
]
} |
examination of t lymphocytes bearing fc receptors for igm showed the presence of circumscribed deposits of esterase activity , while t cells with fc receptors for igg showed of predominantly diffuse granular pattern . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t lymphocytes",
"pos": [
15,
28
]
} | {
"id": "C0034790",
"name": "t cells",
"pos": [
133,
140
]
} |
thyrotropin binding and adenylate cyclase activation in normal and neoplastic human thyroid tissue : lack of effect of thyroglobulin . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
84,
91
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
119,
132
]
} |
the findings in this case are discussed in relation to the hypothesis that displaced , hypothalamic-type ganglion cells may produce a growth hormone-releasing factor that stimulates the development of a growth hormone-secreting pituitary adenoma . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
87,
99
]
} | {
"id": "C0037668",
"name": "growth",
"pos": [
203,
209
]
} |
thus the increase in protein breakdown in the muscle from the burned region appears to be responsible for the loss in muscle protein . | tissue_is_expression_site_of_gene_product | {
"id": "C0026845",
"name": "muscle",
"pos": [
46,
52
]
} | {
"id": "C0026832",
"name": "muscle protein",
"pos": [
118,
132
]
} |
to evaluate the role of cholinergic neurones within the hypothalamus in modulating pancreatic-endocrine function , plasma levels of glucagon , insulin and glucose were measured after microinjection of acetylcholine into the ventromedial hypothalamic nucleus ( vmh ) of rabbits . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "pancreatic-endocrine",
"pos": [
83,
103
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
143,
150
]
} |
treatment of the hypothalamus with m had no effect on basal but inhibited the da-stimulated release of lhrh . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
17,
29
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
103,
107
]
} |
these data are most consistent with the concept that precursor t cells express anti-mhc receptors prior to their entry into the thymus and that exposure to mhc determinants prethymically results in their functional inactivation . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
63,
70
]
} | {
"id": "C0034790",
"name": "mhc receptors",
"pos": [
84,
97
]
} |
blood k+ , hematocrit , red blood cell , white blood cell , hemoglobin , uric acid , cholesterol , blood urea nitrogen and alkaline phosphatase concentrations were all increased , while the total protein and albumin contents were decreased after i.p . injection of pr toxin . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red blood cell",
"pos": [
24,
38
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
60,
70
]
} |
increased release of beta-glucuronidase from mpm to the medium during cultivation with 10 ( 2 ) u per ml of ifn-beta was also observed . | tissue_is_expression_site_of_gene_product | {
"id": "C0024432",
"name": "medium",
"pos": [
56,
62
]
} | {
"id": "C0015980",
"name": "ifn-beta",
"pos": [
108,
116
]
} |
enrichment of four individual plasma components ( alpha 1-antitrypsin , caeruloplasmin , antithrombin iii and haemopexin ) was between 10-fold and 75-fold . | tissue_is_expression_site_of_gene_product | {
"id": "C0032105",
"name": "plasma",
"pos": [
30,
36
]
} | {
"id": "C0019067",
"name": "haemopexin",
"pos": [
110,
120
]
} |
the authors studied in the microsomal and polyribosomal protein-synthesizing system of the thyroid gland a combination of carbohydrate components of thyroglobulin by the incorporation of labeled d-glucosamine-14c , d-mannose-14c , and galactose-14c . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid gland",
"pos": [
91,
104
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
149,
162
]
} |
it is suggested that hypothalamic cholinergic synapses may play a role in stimulating the increased lhrh release which induces the postcastration rise in gonadotropins . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
21,
33
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
100,
104
]
} |
in the cell-mediated immune ( cmi ) system lymphocytes from sensitized animals incubated with antigen manufacture and release lymphokines which activate the hexose-monophosphate shunt in macrophages . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocytes",
"pos": [
43,
54
]
} | {
"id": "C0024297",
"name": "lymphokines",
"pos": [
126,
137
]
} |
the liver was normal microscopically , with no evidence of bile duct obstruction . alpha-fetoprotein in the tumor tissue was detected by immunoprecipitation reaction in agar . | tissue_is_expression_site_of_gene_product | {
"id": "C0023884",
"name": "liver",
"pos": [
4,
9
]
} | {
"id": "C0002210",
"name": "alpha-fetoprotein",
"pos": [
83,
100
]
} |
insulin release and the microtubular system of the islets of langerhans : effects of insulin secretagogues on microtubule subunit pool size . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "of",
"pos": [
44,
46
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
85,
92
]
} |
an assay system was devised to estimate the pool size of microtubule subunits in islet cells , and to study the importance of the equilibrium between polymerised microtubules and their subunits in the regulation of insulin release . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "islet cells",
"pos": [
81,
92
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
215,
222
]
} |
a normal hypothalamic-pituitary gonadotropin function was demonstrated by the finding of normal levels of luteinizing and follicle-stimulating hormones in blood samples drawn at frequent intervals and by normal responses to gonadotropin-releasing hormone and testosterone administration . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
9,
21
]
} | {
"id": "C0023610",
"name": "gonadotropin-releasing",
"pos": [
224,
246
]
} |
tissues from normal thyroid , euthyroid multinodular goiter , toxic goiter , hashimoto 's thyroiditis , thyroid adenoma , and carcinoma were examined for their content of deoxyribonucleic acid ( dna ) , thyroid peroxidase activity ( tpa ) , thyroglobulin ( tg ) , and adenosine 3',5'-cyclic monophosphate ( camp ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
20,
27
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
241,
254
]
} |
in the present series of experiments we examined the ability of eight continuous cell lines derived from human lymphocytes to release lymphokines into their culture media . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocytes",
"pos": [
111,
122
]
} | {
"id": "C0024297",
"name": "lymphokines",
"pos": [
134,
145
]
} |
erythrocyte calcium content increases from 15-20 to 120-150 nmol/g hemoglobin after incubation for 2 h at 20 degree c in a 400 mosmol/kg , ph 7.8 solution containing 100 mm sodium chloride , 90 mm tetramethylammonium chloride , 1 mm potassium chloride , and 10 mm calcium chloride . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
0,
11
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
67,
77
]
} |
it is proposed that oestrogens may influence prostaglandin synthesis in the hypothalamus in relation to lh releasing hormone ( lh.rh ) synthesis and release . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
76,
88
]
} | {
"id": "C0023610",
"name": "lh releasing hormone",
"pos": [
104,
124
]
} |
mononuclear cells from both adult and cord blood produced adequate quantities of lif , indicating that neonatal lymphocytes have the ability to manufacture normal amounts of lymphokines . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocytes",
"pos": [
112,
123
]
} | {
"id": "C0024297",
"name": "lymphokines",
"pos": [
174,
185
]
} |
increased plasma erythropoietin ( esf ) activity , a rise in rbc 2,3-dpg , and a 'right shift ' of the oxygen hemoglobin equilibrium curve following androgen administration to mice in ambient or hyperoxic conditions , was demonstrated . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "rbc",
"pos": [
61,
64
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
110,
120
]
} |
the diagnostic contribution of some examination methods was evaluated ( laparoscopy with the aimed liver biopsy in 50 % of the cases , isotopic methods in 34.6 % of cases , roentgenologic methods in 36.0 % of cases , detection of alpha-1 fetoprotein in serum in 55.5 % of cases ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0023884",
"name": "liver",
"pos": [
99,
104
]
} | {
"id": "C0002210",
"name": "alpha-1 fetoprotein",
"pos": [
230,
249
]
} |
there was about 20 % inhibition of brain and body growth , but no interference with the developmental formation of several cerebral enzymes ( four dehydrogenases , hexokinase and glutaminase ) was detected . | tissue_is_expression_site_of_gene_product | {
"id": "C0006104",
"name": "brain",
"pos": [
35,
40
]
} | {
"id": "C0017796",
"name": "glutaminase",
"pos": [
179,
190
]
} |
to investigate the functional capacity of the anterior pituitary gland in hyperemesis gravidarum , the serum levels of follicle stimulating hormone ( fsh ) , thyrotrophin ( tsh ) , human growth hormone ( hgh ) and prolactin were measured before and after the combined administration of gonadotrophin and thyrotrophin releasing hormones , ( gnrh , trh ) , and insulin in seven normal pregnancies , nine with hyperemesis and eight nonpregnant subjects . | tissue_is_expression_site_of_gene_product | {
"id": "C0032008",
"name": "anterior pituitary gland",
"pos": [
46,
70
]
} | {
"id": "C0033371",
"name": "prolactin",
"pos": [
214,
223
]
} |
to investigate the functional capacity of the anterior pituitary gland in hyperemesis gravidarum , the serum levels of follicle stimulating hormone ( fsh ) , thyrotrophin ( tsh ) , human growth hormone ( hgh ) and prolactin were measured before and after the combined administration of gonadotrophin and thyrotrophin releasing hormones , ( gnrh , trh ) , and insulin in seven normal pregnancies , nine with hyperemesis and eight nonpregnant subjects . | tissue_is_expression_site_of_gene_product | {
"id": "C0032008",
"name": "anterior pituitary gland",
"pos": [
46,
70
]
} | {
"id": "C0040160",
"name": "thyrotrophin",
"pos": [
304,
316
]
} |
a detailed interpretation of the grossly distorted ultraviolet absorption and circular dichroism spectra of the intact red blood cell is given , including an evaluation of the effects of protein conformation , detector geometry , cell hemoglobin content , and refractive index on the calculated cell spectra . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red blood cell",
"pos": [
119,
133
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
235,
245
]
} |
the relatively low sensitivity of the red blood cell suspension circular dichroism spectrum to hemoglobin conformation is due to the order of magnitude flattening of circular dichroism intensity . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red blood cell",
"pos": [
38,
52
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
95,
105
]
} |
that the incubation supernatant of isolated thyroid cells did contain free thyroxine but not iodotyrosines suggests that the normal mechanisms of proteolysis of thyroglobulin and deiodination of iodotyrosines inside the cells are preserved . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
44,
51
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
161,
174
]
} |
in cultivated adenohypophysial primordia of embryos on the 15th day of intrauterine life acth , prolactin , lh and tsh cells are evident , but only the same two kinds of granular cells can be observed with the electron microscope . | tissue_is_expression_site_of_gene_product | {
"id": "C0032008",
"name": "adenohypophysial",
"pos": [
14,
30
]
} | {
"id": "C0033371",
"name": "prolactin",
"pos": [
96,
105
]
} |
reduced glutathione in high concentrations , as in the red cell , substantially diminished binding of oxidized dmap to hemoglobin by formation of s , s , s- ( 2-dimethylamino-5-hydroxy-1,3,4-phenylene ) -tris-glutathione ( tris- ( gs ) -dmap ) , which does not form ferrihemoglobin . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cell",
"pos": [
55,
63
]
} | {
"id": "C0025635",
"name": "ferrihemoglobin",
"pos": [
266,
281
]
} |
the formation of tris ( gs ) -dmap in red cells was found to be of importance for the termination of catalytic ferrihemoglobin formation by dmap in vivo . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red",
"pos": [
38,
41
]
} | {
"id": "C0025635",
"name": "ferrihemoglobin",
"pos": [
111,
126
]
} |
oxygen-binding , plasma and intra-erythrocytic ph , and haemoglobin , 2,3-diphosphoglycerate and inorganic phosphate concentrations were measured in sixty-two healthy non-smokers aged between 18 and 89 years . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocytic",
"pos": [
34,
46
]
} | {
"id": "C0019046",
"name": "haemoglobin",
"pos": [
56,
67
]
} |
the finding of pra in hypothalamic extracts separate from both trh and vp is evidence for the existence of a distinct prolactin-releasing factor . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
22,
34
]
} | {
"id": "C0023610",
"name": "prolactin-releasing factor",
"pos": [
118,
144
]
} |
[ on the mechanism of action of hypothalamic frf and lrf hormones ( fsh and lh releasing factors ) ] . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
32,
44
]
} | {
"id": "C0023610",
"name": "frf",
"pos": [
45,
48
]
} |
[ biosynthesis , release and decomposition of insulin , with special reference to the insulin release mechanism in the microdissected islets of langerhans of mammals . effect of insulin administration on secretion of endogenous insulin ] . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "islets of langerhans",
"pos": [
134,
154
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
228,
235
]
} |
red blood cell replacement during the transition from embryonic ( tadpole ) hemoglobino adult ( frog ) hemoglobin in rana catesbeiana . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red blood cell",
"pos": [
0,
14
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
103,
113
]
} |
data herewith reported on three sibs with figd supported the following conclusions : 1 ) figd is due to insufficient hypothalamic luteinizing hormone-releasing hormone ( lrh ) secretion , 2 ) the sensitivity of leydig cells to hcg is normal , 3 ) lrh treatment may be helpful in these patients , 4 ) an associated hypothalamic-pituitary-prolactin ( prl ) dysfunction may also be present , and 5 ) figd and the kallmann syndrome are different entities having a similar pathophysiology but different cause and overall clinical picture . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
117,
129
]
} | {
"id": "C0023610",
"name": "lrh",
"pos": [
247,
250
]
} |
distribution of c cells in monkey thyroid glands as studied by the immunoperoxidase method using anti-calcitonin and anti-c-thyroglobulin antisera . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid glands",
"pos": [
34,
48
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
124,
137
]
} |
the distribution of c cells in the thyroid glands of eight young adult monkeys ( 4 macaca fuscata and 4 macaca irus ) was investigated by complete serial sections utilizing the immunoperoxidase method with anti-human calcitonin and anti-dog c-thyroglobulin antisera . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid glands",
"pos": [
35,
49
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
243,
256
]
} |
in time-course studies of red cells containing oxyhaemoglobin , methaemoglobin or carbonmono-oxyhaemoglobin incubated without glucose and exposed to t-butyl hydroperoxide , haemoglobin oxidation paralleled both lipid peroxidation and t-butyl hydroperoxide consumption . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cells",
"pos": [
26,
35
]
} | {
"id": "C0025635",
"name": "methaemoglobin",
"pos": [
64,
78
]
} |
in time-course studies of red cells containing oxyhaemoglobin , methaemoglobin or carbonmono-oxyhaemoglobin incubated without glucose and exposed to t-butyl hydroperoxide , haemoglobin oxidation paralleled both lipid peroxidation and t-butyl hydroperoxide consumption . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cells",
"pos": [
26,
35
]
} | {
"id": "C0030069",
"name": "oxyhaemoglobin",
"pos": [
93,
107
]
} |
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