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the effects of repeated treatment of rats with the antidepressant or potential antidepressant agents alaproclate , citalopram , clomipramine , desipramine , imipramine , maprotiline , mianserin and zimeldine on the convulsions released by decapitation were examined . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
51,
65
]
} | {
"id": "C0009010",
"name": "clomipramine",
"pos": [
128,
140
]
} |
the effects of repeated treatment of rats with the antidepressant or potential antidepressant agents alaproclate , citalopram , clomipramine , desipramine , imipramine , maprotiline , mianserin and zimeldine on the convulsions released by decapitation were examined . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
51,
65
]
} | {
"id": "C0011685",
"name": "desipramine",
"pos": [
143,
154
]
} |
the effects of repeated treatment of rats with the antidepressant or potential antidepressant agents alaproclate , citalopram , clomipramine , desipramine , imipramine , maprotiline , mianserin and zimeldine on the convulsions released by decapitation were examined . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
51,
65
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
157,
167
]
} |
the 3 antiarrhythmic drugs currently used by paramedics for cardiac arrest are bretylium , lidocaine , and procainamide . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drugs",
"pos": [
6,
26
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
91,
100
]
} |
the 3 antiarrhythmic drugs currently used by paramedics for cardiac arrest are bretylium , lidocaine , and procainamide . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drugs",
"pos": [
6,
26
]
} | {
"id": "C0033216",
"name": "procainamide",
"pos": [
107,
119
]
} |
five antirheumatic agents , auranofin , levamisole , d-penicillamine , chloroquine and aurothioglucose , were tested and none inhibited the disease process . | therapeutic_class_of | {
"id": "C0003191",
"name": "antirheumatic agents",
"pos": [
5,
25
]
} | {
"id": "C0030817",
"name": "penicillamine",
"pos": [
55,
68
]
} |
some other antiarrhythmic agents also showed similar effects in vitro , but these effects were considerably lower than that of quinidine . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agents",
"pos": [
11,
32
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
127,
136
]
} |
antimalarial activities of chloroquine , mefloquine , amodiaquine , and quinine in vitro against plasmodium falciparum were diminished as a consequence of membrane filtration . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial",
"pos": [
0,
12
]
} | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
27,
38
]
} |
antimalarial activities of chloroquine , mefloquine , amodiaquine , and quinine in vitro against plasmodium falciparum were diminished as a consequence of membrane filtration . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial",
"pos": [
0,
12
]
} | {
"id": "C0025153",
"name": "mefloquine",
"pos": [
41,
51
]
} |
two other antiarrhythmic agents , lidocaine and procainamide , did not compete for binding to alpha-adrenergic receptors . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agents",
"pos": [
10,
31
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
34,
43
]
} |
two other antiarrhythmic agents , lidocaine and procainamide , did not compete for binding to alpha-adrenergic receptors . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agents",
"pos": [
10,
31
]
} | {
"id": "C0033216",
"name": "procainamide",
"pos": [
48,
60
]
} |
[ interference with the antibacterial action of cefuroxime by normal and uremic human serum . preliminary note ] . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
24,
37
]
} | {
"id": "C0007562",
"name": "cefuroxime",
"pos": [
48,
58
]
} |
similarly , the antibacterial activity of penicillin g , oxacillin , cephalothin and cefamandole against staphylococcus aureus was augmented by misg . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
16,
29
]
} | {
"id": "C0030827",
"name": "penicillin",
"pos": [
42,
52
]
} |
similarly , the antibacterial activity of penicillin g , oxacillin , cephalothin and cefamandole against staphylococcus aureus was augmented by misg . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
16,
29
]
} | {
"id": "C0029983",
"name": "oxacillin",
"pos": [
57,
66
]
} |
disk diffusion antimicrobial susceptibility testing of members of the family legionellaceae including erythromycin-resistant variants of legionella micdadei . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial",
"pos": [
15,
28
]
} | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
102,
114
]
} |
this system was standardized by comparing the zone sizes with the mics for 20 antimicrobial agents of nine bacterial strains in five legionella species and of 19 laboratory-derived , erythromycin-resistant variants of legionella micdadei . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial agents",
"pos": [
78,
98
]
} | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
183,
195
]
} |
disk susceptibility testing could be employed to screen legionella isolates for resistance to any of these antimicrobial agents , of which only erythromycin is known to be efficacious in the treatment of legionellosis . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial agents",
"pos": [
107,
127
]
} | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
144,
156
]
} |
it was found , that only the basal antirheumatic drugs d-penicillamine , auranofin , chloroquine and levamisole and also bm 41.332 led to a potentiation of the dth reactions . | therapeutic_class_of | {
"id": "C0003191",
"name": "antirheumatic drugs",
"pos": [
35,
54
]
} | {
"id": "C0030817",
"name": "penicillamine",
"pos": [
57,
70
]
} |
[ antibacterial effect of certain associations of streptomycin with other chemotherapeutic agents in experimental tuberculosis in guinea pig ] . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
2,
15
]
} | {
"id": "C0038425",
"name": "streptomycin",
"pos": [
50,
62
]
} |
when candida cells were grown in mixed cultures with escherichia coli , salmonella typhimurium , or pseudomonas aeruginosa , their sensitivity to antifungal agents affecting sterol metabolism or functioning ( polyenes and miconazole ) was increased by several log units . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal agents",
"pos": [
146,
163
]
} | {
"id": "C0025942",
"name": "miconazole",
"pos": [
222,
232
]
} |
antifungals without direct effect on sterol metabolism ( 5-fluorocytosine , methylparaben , and 4-hydroxyquinazoline ) were not more active in mixed than in pure cultures . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungals",
"pos": [
0,
11
]
} | {
"id": "C0016278",
"name": "5-fluorocytosine",
"pos": [
57,
73
]
} |
high performance liquid chromatographic analysis of the antiarrhythmic drugs procainamide , disopyramide , quinidine , propranolol and metabolites from serum extracts . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drugs",
"pos": [
56,
76
]
} | {
"id": "C0033216",
"name": "procainamide",
"pos": [
77,
89
]
} |
high performance liquid chromatographic analysis of the antiarrhythmic drugs procainamide , disopyramide , quinidine , propranolol and metabolites from serum extracts . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drugs",
"pos": [
56,
76
]
} | {
"id": "C0012702",
"name": "disopyramide",
"pos": [
92,
104
]
} |
high performance liquid chromatographic analysis of the antiarrhythmic drugs procainamide , disopyramide , quinidine , propranolol and metabolites from serum extracts . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drugs",
"pos": [
56,
76
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
107,
116
]
} |
of a number of neuroleptics tested , haloperidol , fluphenazine , sultopride , tiapride , sulpiride and thioridazine , only the latter two showed greater effectiveness than normal to antagonize the apomorphine responses after mesolimbic denervation . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
15,
27
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
37,
48
]
} |
relevance of in vitro antibacterial activities of cefotiam and cefazolin to their therapeutic effects on experimental pneumonia caused by klebsiella pneumoniae dt-s in mice . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
22,
35
]
} | {
"id": "C0007546",
"name": "cefazolin",
"pos": [
63,
72
]
} |
although the mechanism underlying this potentiation of the antiepileptic effects of valproic acid and diazepam remains unknown , levonantradol may have potential as adjunctive therapy in the treatment of complex partial seizures . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic",
"pos": [
59,
72
]
} | {
"id": "C0042291",
"name": "valproic acid",
"pos": [
84,
97
]
} |
a 4-wk double-blind controlled study of the antidepressant efficacy of the triazolopyridine derivative trazodone , in contrast to imipramine and placebo , was carried out in 30 endogenously depressed outpatients . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
44,
58
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
130,
140
]
} |
the antipsychotic butyrophenones haloperidol and butaclamol compete with comparably high affinities for [ 3h ] spiroperidol binding sites in all of the above brain regions . | therapeutic_class_of | {
"id": "C0040615",
"name": "antipsychotic",
"pos": [
4,
17
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
33,
44
]
} |
the actions of two clinically important dibenzocycloheptane antidepressant drugs , amitriptyline and nortriptyline , were studied on ionic channels of nicotinic acetylcholine ( accho ) receptors at the neuromuscular junction of frog skeletal muscle . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
60,
74
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
83,
96
]
} |
the actions of two clinically important dibenzocycloheptane antidepressant drugs , amitriptyline and nortriptyline , were studied on ionic channels of nicotinic acetylcholine ( accho ) receptors at the neuromuscular junction of frog skeletal muscle . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
60,
74
]
} | {
"id": "C0028420",
"name": "nortriptyline",
"pos": [
101,
114
]
} |
rhesus monkeys , previously subjected to twice-weekly injections of various neuroleptics , subsequently respond to acute im injections of haloperidol with marked bucco-lingual and whole body movement disturbances consisting of mouth opening , protrusion , retraction or curling of the tongue together with writhing movements of the neck , trunk and/or limbs . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
76,
88
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
138,
149
]
} |
low dose apomorphine-induced hypothermia ( 1 mg/kg ) differentiates sulpiride-like neuroleptics ( which better antagonize this effect of apomorphine than other effects such as stereotyped behavior ) from haloperidol-like drugs . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
83,
95
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
204,
215
]
} |
hypothermia induced by a high dose of apomorphine ( 16 mg/kg ) is not antagonized by neuroleptics , but is strongly antagonized by antidepressants ( imipramine-like drugs , amineptine , amoxapine , nomifensine , viloxazine ) and potential antidepressants ( beta-adrenergic stimulants ) . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
131,
146
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
149,
159
]
} |
hypothermia induced by a high dose of apomorphine ( 16 mg/kg ) is not antagonized by neuroleptics , but is strongly antagonized by antidepressants ( imipramine-like drugs , amineptine , amoxapine , nomifensine , viloxazine ) and potential antidepressants ( beta-adrenergic stimulants ) . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
131,
146
]
} | {
"id": "C0002644",
"name": "amoxapine",
"pos": [
186,
195
]
} |
in an estimated 5 % of patients , antiarrhythmic therapy with amiodarone ( cordarone ) may have side effects involving thyroid function . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
34,
48
]
} | {
"id": "C0002598",
"name": "amiodarone",
"pos": [
62,
72
]
} |
a new anti-arrhythmic agent , lorcainide , has been compared with lignocaine in patients with acute myocardial infarction . | therapeutic_class_of | {
"id": "C0003195",
"name": "anti-arrhythmic agent",
"pos": [
6,
27
]
} | {
"id": "C0023660",
"name": "lignocaine",
"pos": [
66,
76
]
} |
clinical electrophysiologic study of antiarrhythmic properties of flecainide : acute intraventricular delayed conduction and prolonged repolarization in regular paced and premature beats using intracardiac monophasic action potentials with programmed stimulation . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
37,
51
]
} | {
"id": "C0016229",
"name": "flecainide",
"pos": [
66,
76
]
} |
lithium citrate syrup ( 5 or 10 ml ) was mixed with four volumes ( representing minimal to maximal clinical dosages ) of each of 10 liquid neuroleptic drug products -- chlorpromazine hydrochloride , haloperidol lactate , thioridazine hydrochloride , trifluoperazine hydrochloride , fluphenazine hydrochloride , loxapine hydrochloride , mesoridazine besylate , molindone hydrochloride , perphenazine , and thiothixene hydrochloride . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic drug",
"pos": [
139,
155
]
} | {
"id": "C0720809",
"name": "haloperidol lactate",
"pos": [
199,
218
]
} |
lithium citrate syrup ( 5 or 10 ml ) was mixed with four volumes ( representing minimal to maximal clinical dosages ) of each of 10 liquid neuroleptic drug products -- chlorpromazine hydrochloride , haloperidol lactate , thioridazine hydrochloride , trifluoperazine hydrochloride , fluphenazine hydrochloride , loxapine hydrochloride , mesoridazine besylate , molindone hydrochloride , perphenazine , and thiothixene hydrochloride . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic drug",
"pos": [
139,
155
]
} | {
"id": "C0282249",
"name": "molindone hydrochloride",
"pos": [
360,
383
]
} |
lithium citrate syrup ( 5 or 10 ml ) was mixed with four volumes ( representing minimal to maximal clinical dosages ) of each of 10 liquid neuroleptic drug products -- chlorpromazine hydrochloride , haloperidol lactate , thioridazine hydrochloride , trifluoperazine hydrochloride , fluphenazine hydrochloride , loxapine hydrochloride , mesoridazine besylate , molindone hydrochloride , perphenazine , and thiothixene hydrochloride . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic drug",
"pos": [
139,
155
]
} | {
"id": "C0304386",
"name": "thiothixene hydrochloride",
"pos": [
405,
430
]
} |
it potentiated the antibacterial action of ampicillin in vitro against beta-lactamase-producing strains of staphylococcus aureus , haemophilus influenzae , bacteroides fragilis . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
19,
32
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
43,
53
]
} |
the anthelmintic effects of pyrantel pamoate , oxantel-pyrantel pamoate , levamisole and mebendazole in the treatment of intestinal nematodes . | therapeutic_class_of | {
"id": "C0003158",
"name": "anthelmintic",
"pos": [
4,
16
]
} | {
"id": "C0025023",
"name": "mebendazole",
"pos": [
89,
100
]
} |
antibacterial effectiveness studies in the conjunctiva showed that tobramycin eradicated or controlled 87.8 % of the bacterial infections vs . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
0,
13
]
} | {
"id": "C0040341",
"name": "tobramycin",
"pos": [
67,
77
]
} |
the antibody formation was slightly suppressed by d-pa under various conditions induced by different quantities of antigen stimuli , while the effects of the other antirheumatic drugs and the immunosuppressive agents on the primary and secondary responses differed from that of d-pa . | therapeutic_class_of | {
"id": "C0003191",
"name": "antirheumatic drugs",
"pos": [
164,
183
]
} | {
"id": "C0030817",
"name": "d-pa",
"pos": [
278,
282
]
} |
nippostrongylus brasiliensis was found to be sensitive to thiabendazole , tetramisole and levamisole but the broad spectrum anthelmintic mebendazole was ineffective . | therapeutic_class_of | {
"id": "C0003158",
"name": "anthelmintic",
"pos": [
124,
136
]
} | {
"id": "C0025023",
"name": "mebendazole",
"pos": [
137,
148
]
} |
the antibacterial activity of netilmicin ( sch 20569 ) , a new semisynthetic aminoglycoside , was compared with that of gentamicin against a variety of gram-negative bacteria , staphylococci , and streptococci . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0027780",
"name": "netilmicin",
"pos": [
30,
40
]
} |
the in vitro antibacterial activity of cinoxacin was compared with that of ampicillin and chloramphenicol against 26 strains of nontyphoid salmonella and 44 strains of shigella . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
13,
26
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
75,
85
]
} |
the in vitro antibacterial activity of cinoxacin was compared with that of ampicillin and chloramphenicol against 26 strains of nontyphoid salmonella and 44 strains of shigella . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
13,
26
]
} | {
"id": "C0008168",
"name": "chloramphenicol",
"pos": [
90,
105
]
} |
early and adequate intravenous antiarrhythmic prophylaxis with lidocaine to raise the fibrillation threshold in the setting of coronary insufficiency can prevent primary ventricular fibrillation . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
31,
45
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
63,
72
]
} |
[ study on the antibacterial activity in vitro , blood and urinary levels of a 1:1 combination of amoxicillin and dicloxacillin ] . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
15,
28
]
} | {
"id": "C0002645",
"name": "amoxicillin",
"pos": [
98,
109
]
} |
[ study on the antibacterial activity in vitro , blood and urinary levels of a 1:1 combination of amoxicillin and dicloxacillin ] . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
15,
28
]
} | {
"id": "C0012093",
"name": "dicloxacillin",
"pos": [
114,
127
]
} |
on the grounds of different pharmacological properties and possibly different clinical effects , two antidepressants , anafranil ( clomipramine ) and pertofran ( desipramine ) were compared in the management of depression in general practice . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
101,
116
]
} | {
"id": "C0009010",
"name": "clomipramine",
"pos": [
131,
143
]
} |
on the grounds of different pharmacological properties and possibly different clinical effects , two antidepressants , anafranil ( clomipramine ) and pertofran ( desipramine ) were compared in the management of depression in general practice . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
101,
116
]
} | {
"id": "C0011685",
"name": "desipramine",
"pos": [
162,
173
]
} |
the combination of behavioural techniques of desensitization along a hierarchy of anxiety-provoking situations , together with psychotherapeutic support and the simultaneous exhibition of the more specific antidepressant and antiphobic preparation clomipramine would offer the best hope of symptom relief . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
206,
220
]
} | {
"id": "C0009010",
"name": "clomipramine",
"pos": [
248,
260
]
} |
some methodological considerations for the clinical evaluation of neuroleptics -- comparative effects of clozapine and haloperidol on schizophrenics . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
66,
78
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
119,
130
]
} |
the in vitro antibacterial activity of two agents relatively resistant to beta-lactamases , bl-s786 and cefoxitin , was tested against 123 recent different clinical isolates of cephalothin-resistant enterobacteriaceae . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
13,
26
]
} | {
"id": "C0007557",
"name": "cefoxitin",
"pos": [
104,
113
]
} |
[ condition of the liver in patients with chronic pulmonary tuberculosis receiving a combination of antibacterial drugs including rifampicin and ethambutol ] . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
100,
113
]
} | {
"id": "C0035608",
"name": "rifampicin",
"pos": [
130,
140
]
} |
the effect of antidepressant melipramine ( imipramine ) on the na+ , k+-atpase activity was studied in the brain synaptosomes as dependent on the sodium and potassium ions concentration and ph of the incubation medium . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
14,
28
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
43,
53
]
} |
of the numerous antiviral drugs being investigated , the following seem to show promise : idoxuridine , adenin arabinoside , trifluorothymidine , phosphonoacetic acid , and ribavirin . | therapeutic_class_of | {
"id": "C0003451",
"name": "antiviral drugs",
"pos": [
16,
31
]
} | {
"id": "C0040987",
"name": "trifluorothymidine",
"pos": [
125,
143
]
} |
although the antimalarial agents chloroquine , hydroxychloroquine , and amodiaquine are widely used to treat a variety of medical conditions , their behavioral toxicity and lethality are not generally recognized . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial agents",
"pos": [
13,
32
]
} | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
54,
65
]
} |
[ studies on antiarrhythmic effects and toxicity of quinidine and dihydroquinidine as well as defined mixtures of both in rats ( author 's transl ) ] . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
13,
27
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
73,
82
]
} |
the antiarrhythmic and acute toxic actions of quinidine ( q ) and dihydroquinidine ( dhq ) were investigated in experiments in rats . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
4,
18
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
73,
82
]
} |
we describe a routine method for determining concentrations of the antiarrhythmic drug procainamide and its active metabolite , n-acetylprocainamide , in plasma . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
67,
81
]
} | {
"id": "C0033216",
"name": "procainamide",
"pos": [
136,
148
]
} |
the effect of an antiepileptic drug , valproic acid ( vpa ) , on an experimental form of epilepsy , the kindling phenomenon , is described . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic",
"pos": [
17,
30
]
} | {
"id": "C0042291",
"name": "valproic acid",
"pos": [
38,
51
]
} |
for 6 large series of compounds derived from the piperidine moieties of spiperone , pimozide , haloperidol , pethidine , fentanyl and 4-methocarboxy-fentanyl , ic50 values were determined in the opiate and neuroleptic binding assay using [ 3h ] -fentanyl and [ 3h ] -haloperidol as ligands , respectively . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
206,
217
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
267,
278
]
} |
open trial and double-blind clinical trial of the antidepressant ro 8-1998 in comparison with imipramine . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
50,
64
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
94,
104
]
} |
quantitation of the antimalarial agent , mefloquine , in blood , plasma , and urine using high-pressure liquid chromatography . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial agent",
"pos": [
20,
38
]
} | {
"id": "C0025153",
"name": "mefloquine",
"pos": [
41,
51
]
} |
the most potent compound , 1- [ 2- ( 2-ethylaminoacetyl ) amino-3,4-dimethoxybenzyl ] isoquinoline ( 7 ) , showed greater antiarrhythmic potency , was considerably less toxic than lidocaine , and is a candidate for further evaluation . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
122,
136
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
180,
189
]
} |
since that event , at least nine such strains were isolated in 1976 , and the presence of transferable resistant to the antibiotics listed plus other antibacterial substances including carbenicillin and more classical antibiotics could be demonstrated either by a high-frequence direct transfer to suitable recipient strains of gentamycin or tobramycin resistance , or by indirect selection , i.e . by analysis of exconjugants selected with kanamycin , streptomycin or carbenicillin . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
150,
163
]
} | {
"id": "C0040341",
"name": "tobramycin",
"pos": [
342,
352
]
} |
since that event , at least nine such strains were isolated in 1976 , and the presence of transferable resistant to the antibiotics listed plus other antibacterial substances including carbenicillin and more classical antibiotics could be demonstrated either by a high-frequence direct transfer to suitable recipient strains of gentamycin or tobramycin resistance , or by indirect selection , i.e . by analysis of exconjugants selected with kanamycin , streptomycin or carbenicillin . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
150,
163
]
} | {
"id": "C0022487",
"name": "kanamycin",
"pos": [
441,
450
]
} |
since that event , at least nine such strains were isolated in 1976 , and the presence of transferable resistant to the antibiotics listed plus other antibacterial substances including carbenicillin and more classical antibiotics could be demonstrated either by a high-frequence direct transfer to suitable recipient strains of gentamycin or tobramycin resistance , or by indirect selection , i.e . by analysis of exconjugants selected with kanamycin , streptomycin or carbenicillin . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
150,
163
]
} | {
"id": "C0038425",
"name": "streptomycin",
"pos": [
453,
465
]
} |
since that event , at least nine such strains were isolated in 1976 , and the presence of transferable resistant to the antibiotics listed plus other antibacterial substances including carbenicillin and more classical antibiotics could be demonstrated either by a high-frequence direct transfer to suitable recipient strains of gentamycin or tobramycin resistance , or by indirect selection , i.e . by analysis of exconjugants selected with kanamycin , streptomycin or carbenicillin . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
150,
163
]
} | {
"id": "C0006976",
"name": "carbenicillin",
"pos": [
469,
482
]
} |
hemodynamic effects of two antiarrhythmic agents , disopyramide and procainamide , have been evaluated in anesthetized open-chest healthy pigs after random administration . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agents",
"pos": [
27,
48
]
} | {
"id": "C0012702",
"name": "disopyramide",
"pos": [
51,
63
]
} |
hemodynamic effects of two antiarrhythmic agents , disopyramide and procainamide , have been evaluated in anesthetized open-chest healthy pigs after random administration . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agents",
"pos": [
27,
48
]
} | {
"id": "C0033216",
"name": "procainamide",
"pos": [
68,
80
]
} |
synergy of cp-45,899 and ampicillin was demonstrated at varying concentrations suggesting that it may significantly enlarge the antibacterial activity of ampicillin against resistant bacteria . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
128,
141
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
154,
164
]
} |
the antagonism of neuroleptics of various groups ( chlorpromazine , chlorprothixene , clopenthixol , clozapine , flupenthixol , fluphenazine , haloperidol , levomepromazine , mepazine , perazine , perphenazine , pimozide , prochlorperazine , promazine , spiperone , thiopromazine , thioridazine , trifluperazine , trifluperidol , triflupromazine ) towards l-5-hydroxytryptophan ( 5-htp ) was assessed on the basis of inhibition of characteristic head-twitches . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
18,
30
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
143,
154
]
} |
the antagonism of neuroleptics of various groups ( chlorpromazine , chlorprothixene , clopenthixol , clozapine , flupenthixol , fluphenazine , haloperidol , levomepromazine , mepazine , perazine , perphenazine , pimozide , prochlorperazine , promazine , spiperone , thiopromazine , thioridazine , trifluperazine , trifluperidol , triflupromazine ) towards l-5-hydroxytryptophan ( 5-htp ) was assessed on the basis of inhibition of characteristic head-twitches . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
18,
30
]
} | {
"id": "C0031935",
"name": "pimozide",
"pos": [
212,
220
]
} |
the effect of a new antidepressant drug , c-45 , and imipramine on some hemodynamic parameters in the dog . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
20,
34
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
53,
63
]
} |
patients on long-term treatment with either of the stereochemically related antiepileptic drugs phenytoin ( dph ) or carbamazepine ( cbz ) had similar changes in serum thyroid hormone concentrations . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drugs",
"pos": [
76,
95
]
} | {
"id": "C0031507",
"name": "phenytoin",
"pos": [
96,
105
]
} |
the oral or subcutaneous administration of 19 anthelmintics and filaricides revealed good activity for levamisole , cambendazole , and mebendazole against 15-day-old ancylostoma larvae which were located in the muscular tissue . | therapeutic_class_of | {
"id": "C0003158",
"name": "anthelmintics",
"pos": [
46,
59
]
} | {
"id": "C0025023",
"name": "mebendazole",
"pos": [
135,
146
]
} |
the antibacterial spectrum of cefoxitin was found to be one which included all gram-positive organisms except enterococci , most gram-negative organisms except pseudomonas aeruginosa , and almost all of the important anaerobic organisms . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0007557",
"name": "cefoxitin",
"pos": [
30,
39
]
} |
in vitro drug sensitivity tests indicated good antifungal activity of pimaricin and econazole for f. solani , clotrimazole and econazole for aspergillus fumigatus . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
47,
57
]
} | {
"id": "C0013547",
"name": "econazole",
"pos": [
127,
136
]
} |
the anti-arrhythmic efficacy of perhexiline maleate , disopyramide and mexiletine has been evaluated in 27 patients with chronic ischaemic heart disease who exhibited frequent ventricular ectopic beats ( i.e . greater than or equal to 8/h ) . | therapeutic_class_of | {
"id": "C0003195",
"name": "anti-arrhythmic",
"pos": [
4,
19
]
} | {
"id": "C0012702",
"name": "disopyramide",
"pos": [
54,
66
]
} |
the anti-arrhythmic efficacy of perhexiline maleate , disopyramide and mexiletine has been evaluated in 27 patients with chronic ischaemic heart disease who exhibited frequent ventricular ectopic beats ( i.e . greater than or equal to 8/h ) . | therapeutic_class_of | {
"id": "C0003195",
"name": "anti-arrhythmic",
"pos": [
4,
19
]
} | {
"id": "C0025887",
"name": "mexiletine",
"pos": [
71,
81
]
} |
fifteen of the 17 patients had received other currently conventional anti-arrhythmic therapy , to which only 1 patient responded , yet 13 of these 15 patients with resistant arrhythmias responded to dp . | therapeutic_class_of | {
"id": "C0003195",
"name": "anti-arrhythmic",
"pos": [
69,
84
]
} | {
"id": "C0012702",
"name": "dp",
"pos": [
199,
201
]
} |
the antidiarrheal drugs loperamide and diphenoxylate were tested for their ability to potentiate central nervous system depression induced by ethanol in mice and nethohexital in rats . | therapeutic_class_of | {
"id": "C0003292",
"name": "antidiarrheal drugs",
"pos": [
4,
23
]
} | {
"id": "C0012525",
"name": "diphenoxylate",
"pos": [
39,
52
]
} |
the uptake capacity of granulocytes for l-dopa was suppressed by major tranquilizers especially haloperidol , and by lithium carbonate , while the uptake was enhanced by prednisolone , dexamethasone , mk-486 , and dibutyryl cyclic amp . | therapeutic_class_of | {
"id": "C0040615",
"name": "major tranquilizers",
"pos": [
65,
84
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
96,
107
]
} |
regarding the antidepressive effect , mianserin is superior to placebo and as effective as imipramine and amitriptyline . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressive",
"pos": [
14,
28
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
91,
101
]
} |
regarding the antidepressive effect , mianserin is superior to placebo and as effective as imipramine and amitriptyline . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressive",
"pos": [
14,
28
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
106,
119
]
} |
treatment of diarrhea in irritable colon , including preliminary observations with a new antidiarrheal agent , diphenoxylate hydrochloride ( lomotil ) . | therapeutic_class_of | {
"id": "C0003292",
"name": "antidiarrheal agent",
"pos": [
89,
108
]
} | {
"id": "C0282145",
"name": "diphenoxylate hydrochloride",
"pos": [
111,
138
]
} |
treatment of diarrhea in irritable colon , including preliminary observations with a new antidiarrheal agent , diphenoxylate hydrocloride ( lomotil ) . | therapeutic_class_of | {
"id": "C0003292",
"name": "antidiarrheal agent",
"pos": [
89,
108
]
} | {
"id": "C0282145",
"name": "diphenoxylate hydrocloride",
"pos": [
111,
137
]
} |
in a recent study , we have shown that the antiarrhythmic drug , amiodarone caused significant elevations of serum rt3 levels and inhibition of the peripheral conversion of t4 to t3 ( kannan et al . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drug",
"pos": [
43,
62
]
} | {
"id": "C0002598",
"name": "amiodarone",
"pos": [
65,
75
]
} |
five antipsychotic drugs ( spiperone , chlorpromazine , clozapine , haloperidol , and sulpiride ) were tested for their ability to antagonize these effects of dom in the lc . | therapeutic_class_of | {
"id": "C0040615",
"name": "antipsychotic drugs",
"pos": [
5,
24
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
68,
79
]
} |
some compounds ( vi ) showed antiarrhythmic activity in rats higher or like that of quinidine and platelet antiaggregating activity in vitro like that of acetylsalycilic acid , as well as moderate infiltration anesthesia in mice and weak hypotensive , bradicardic and antiinflammatory activities in rats . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
29,
43
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
84,
93
]
} |
the synthesis of beta-dialkylaminoethyl ethers ( iii a-f ) and gamma-dialkylaminopropyl ethers ( iii g-l ) starting from 1,3,3-trimethyl-5- ( phenylmethylene ) -2-oxabicyclo [ 2.2.2 ] octan-6- hydroxyimine ( ii ) is described . beta-diisopropylaminoethyl ether ( iii b ) and gamma-piperidinopropyl ether ( iii i ) showed an antiarrhythmic activity in rats similar to that of quinidine . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
324,
338
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
375,
384
]
} |
marked interindividual variability has been reported in the plasma concentrations of the antiarrhythmic agent propafenone required for arrhythmia suppression . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agent",
"pos": [
89,
109
]
} | {
"id": "C0033429",
"name": "propafenone",
"pos": [
110,
121
]
} |
neuroleptics ( i.v . ) had less significant or consistent effects on septohippocampal neurons , although the effects of haloperidol were usually inhibitory . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
0,
12
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
120,
131
]
} |
all 8 tested antiepileptics , namely carbamazepine , clonazepam , diazepam , diphenylhydantoin , ethosuximide , flunarizine , phenobarbital and sodium valproate decreased this behaviour in a dose-dependent way . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptics",
"pos": [
13,
27
]
} | {
"id": "C0031507",
"name": "diphenylhydantoin",
"pos": [
77,
94
]
} |
all 8 tested antiepileptics , namely carbamazepine , clonazepam , diazepam , diphenylhydantoin , ethosuximide , flunarizine , phenobarbital and sodium valproate decreased this behaviour in a dose-dependent way . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptics",
"pos": [
13,
27
]
} | {
"id": "C0015043",
"name": "ethosuximide",
"pos": [
97,
109
]
} |
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