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comparative distribution of two antidepressant drugs ( imipramine and indalpine ) in the rat as determined by analog computer simulation . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
32,
46
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
55,
65
]
} |
a ten-compartment analog computer model is presented to determine the precise distribution and excretion of two antidepressant drugs , lm 5008 and imipramine . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant drugs",
"pos": [
112,
132
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
147,
157
]
} |
both in vitro and in vivo , the compound shows promising antibacterial activity when compared with piperacillin and ticarcillin . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
57,
70
]
} | {
"id": "C0031955",
"name": "piperacillin",
"pos": [
99,
111
]
} |
both in vitro and in vivo , the compound shows promising antibacterial activity when compared with piperacillin and ticarcillin . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
57,
70
]
} | {
"id": "C0040193",
"name": "ticarcillin",
"pos": [
116,
127
]
} |
fluphenazine enanthate parenterally was compared to an antipsychotic drug ( haloperidol ) given orally for the `` '' crisis intervention '' '' treatment of elderly outpatients with late paraphrenia . | therapeutic_class_of | {
"id": "C0040615",
"name": "antipsychotic drug",
"pos": [
55,
73
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
76,
87
]
} |
the effect of trazodone , a new antidepressant agent , on uptake of serotonin ( 5-ht ) , norepinephrine ( ne ) , and dopamine ( da ) by crude synaptosome preparations from rat hypothalamus was compared with imipramine , desipramine , and clomipramine . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant agent",
"pos": [
32,
52
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
207,
217
]
} |
the effect of trazodone , a new antidepressant agent , on uptake of serotonin ( 5-ht ) , norepinephrine ( ne ) , and dopamine ( da ) by crude synaptosome preparations from rat hypothalamus was compared with imipramine , desipramine , and clomipramine . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant agent",
"pos": [
32,
52
]
} | {
"id": "C0011685",
"name": "desipramine",
"pos": [
220,
231
]
} |
the effect of trazodone , a new antidepressant agent , on uptake of serotonin ( 5-ht ) , norepinephrine ( ne ) , and dopamine ( da ) by crude synaptosome preparations from rat hypothalamus was compared with imipramine , desipramine , and clomipramine . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant agent",
"pos": [
32,
52
]
} | {
"id": "C0009010",
"name": "clomipramine",
"pos": [
238,
250
]
} |
the anthelmintic efficacy of albendazole against fasciola hepatica and benzimidazole resistant strains of haemonchus contortus and trichostrongylus colubriformis in sheep . | therapeutic_class_of | {
"id": "C0003158",
"name": "anthelmintic",
"pos": [
4,
16
]
} | {
"id": "C0001911",
"name": "albendazole",
"pos": [
29,
40
]
} |
the anthelmintic efficacy of albendazole ( methyl [ 5- ( propylthio ) - 1h - benzimidazole -2 -yl ] carbamate ) against immature and adult fasciola hepatica and against standardised strains of benzimidazole resistant haemonchus contortus and trichostrongylus colubriformis was evaluated in experimentally infected sheep . | therapeutic_class_of | {
"id": "C0003158",
"name": "anthelmintic",
"pos": [
4,
16
]
} | {
"id": "C0001911",
"name": "albendazole",
"pos": [
29,
40
]
} |
a possible neuropharmacologic explanation of the beneficial effects of the neuroleptics , particularly haloperidol , is offered based on the dopamine antagonism of these drugs . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
75,
87
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
103,
114
]
} |
antirheumatic drugs ( prednisolone , acetylsalicylic acid , d-penicillamine and chloroquine ) inhibit the proliferation of cultivated fetal human fibroblasts . | therapeutic_class_of | {
"id": "C0003191",
"name": "antirheumatic drugs",
"pos": [
0,
19
]
} | {
"id": "C0030817",
"name": "penicillamine",
"pos": [
62,
75
]
} |
antirheumatic drugs ( prednisolone , acetylsalicylic acid , d-penicillamine and chloroquine ) , simultaneously added to the cluture eliminate the acceleration of the proliferation induced by staphylolysine or low density lipoprotein . | therapeutic_class_of | {
"id": "C0003191",
"name": "antirheumatic drugs",
"pos": [
0,
19
]
} | {
"id": "C0030817",
"name": "penicillamine",
"pos": [
62,
75
]
} |
in order to correlate the antiarrhythmic and electrophysiological effects of disopyramide phosphate during acute myocardial ischemia , we performed experiments in 17 mongrel dogs . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
26,
40
]
} | {
"id": "C0700534",
"name": "disopyramide phosphate",
"pos": [
77,
99
]
} |
the mechanisms of antiarrhythmic actions of mexiletine are thus complex but resemble those of lignocaine in superfused isolated cardiac muscle . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
18,
32
]
} | {
"id": "C0025887",
"name": "mexiletine",
"pos": [
44,
54
]
} |
the mechanisms of antiarrhythmic actions of mexiletine are thus complex but resemble those of lignocaine in superfused isolated cardiac muscle . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
18,
32
]
} | {
"id": "C0023660",
"name": "lignocaine",
"pos": [
94,
104
]
} |
increased antimycobacterial activity of isoprodian ( isoniazid + prothionamide + dapsone ) may be due to ( i ) decreased mutation rate for inh resistance provoked in mycobacteria by dds ( in 2 of 3 strains tested ) ; | therapeutic_class_of | {
"id": "C0360390",
"name": "antimycobacterial",
"pos": [
10,
27
]
} | {
"id": "C0022209",
"name": "resistance",
"pos": [
143,
153
]
} |
the well-known antiepileptics , trimethadione ( tmo ) , ethosuximide ( esm ) , and phenytoin ( pht ) , were included as reference drugs . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptics",
"pos": [
15,
29
]
} | {
"id": "C0041038",
"name": "trimethadione",
"pos": [
32,
45
]
} |
the well-known antiepileptics , trimethadione ( tmo ) , ethosuximide ( esm ) , and phenytoin ( pht ) , were included as reference drugs . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptics",
"pos": [
15,
29
]
} | {
"id": "C0015043",
"name": "ethosuximide",
"pos": [
56,
68
]
} |
the well-known antiepileptics , trimethadione ( tmo ) , ethosuximide ( esm ) , and phenytoin ( pht ) , were included as reference drugs . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptics",
"pos": [
15,
29
]
} | {
"id": "C0031507",
"name": "phenytoin",
"pos": [
83,
92
]
} |
in this paper we report our results concerning the antagonism between dopaminergic ( bromocriptine , apomorphine , piribedil ) and neuroleptic ( haloperidol , chlorpromazine , reserpine , clotiapine ) drugs on the eeg and behaviour of rabbits . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
131,
142
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
145,
156
]
} |
effect of the antimalarial chloroquine on the phospholipid metabolism of avian malaria and heart tissue . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial",
"pos": [
14,
26
]
} | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
27,
38
]
} |
[ observations on the antibacterial activity of thiamphenicol and chloramphenicol in the presence of bile and of bile salts ] . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
22,
35
]
} | {
"id": "C0008168",
"name": "chloramphenicol",
"pos": [
66,
81
]
} |
[ inhibitors of antibacterial activity and certain secondary aspects of streptomycin in the organism in tuberculosis ] . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
16,
29
]
} | {
"id": "C0038425",
"name": "streptomycin",
"pos": [
72,
84
]
} |
the antiarrhythmic efficacy of intravenous flecainide and intravenous digoxin was assessed in 29 patients ( 26 men ) , aged 43 to 73 ( 63 +/- 7 ) years who developed atrial arrhythmias in the first 96 hours after coronary artery bypass grafting . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
4,
18
]
} | {
"id": "C0016229",
"name": "flecainide",
"pos": [
43,
53
]
} |
low doses of the antipsychotic drug haloperidol attenuated da 's response and reversed the apomorphine-inhibition of impulse flow . | therapeutic_class_of | {
"id": "C0040615",
"name": "antipsychotic drug",
"pos": [
17,
35
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
36,
47
]
} |
the effects of three separate antimalarial prophylactic regimens ( proguanil , sulfisoxazole , and proguanil plus sulfisoxazole ) and of vitamins in a control group were compared in a study population of 380 children living in a malaria endemic area along the thai-burmese border . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial",
"pos": [
30,
42
]
} | {
"id": "C0008241",
"name": "proguanil",
"pos": [
99,
108
]
} |
in patch-clamped membranes from neonatal rat cardiocytes , elementary na+ currents were recorded at 19 degrees c for study of the inhibitory influence of several antiarrhythmic drugs including lidocaine , diprafenone , propafenone , and prajmalium on dpi-modified cardiac na+ channels . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drugs",
"pos": [
162,
182
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
193,
202
]
} |
in patch-clamped membranes from neonatal rat cardiocytes , elementary na+ currents were recorded at 19 degrees c for study of the inhibitory influence of several antiarrhythmic drugs including lidocaine , diprafenone , propafenone , and prajmalium on dpi-modified cardiac na+ channels . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drugs",
"pos": [
162,
182
]
} | {
"id": "C0033429",
"name": "propafenone",
"pos": [
219,
230
]
} |
antiarrhythmic drugs ( propafenone , diprafenone , and , to a lesser extent , lidocaine ) provoke a flicker block , that is , the long-lasting openings are chopped into a large number of short and grouped openings . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drugs",
"pos": [
0,
20
]
} | {
"id": "C0033429",
"name": "propafenone",
"pos": [
23,
34
]
} |
antiarrhythmic drugs ( propafenone , diprafenone , and , to a lesser extent , lidocaine ) provoke a flicker block , that is , the long-lasting openings are chopped into a large number of short and grouped openings . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drugs",
"pos": [
0,
20
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
78,
87
]
} |
antidepressant action of imipramine and iprindole in mice is enhanced by inhibitors of enkephalin-degrading peptidases . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
0,
14
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
25,
35
]
} |
the implication that opioid peptides are involved in the action of the antidepressants imipramine and iprindole was investigated in mice by using the forced swimming test as an experimental model of depression . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
71,
86
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
87,
97
]
} |
although r-rsm-a and s , r-rsm-a were comparable or inferior to both antibiotics , the antimycobacterial activity of s-rsm-a was superior to that of sm and km . | therapeutic_class_of | {
"id": "C0360390",
"name": "antimycobacterial",
"pos": [
87,
104
]
} | {
"id": "C0038425",
"name": "sm",
"pos": [
149,
151
]
} |
its in vitro antifungal activity against aspergillus spp . is rather weak , but in vivo animal protection studies in mice with aspergillus infections showed that the activity of fluconazole was about 15 times as potent as that of ketoconazole . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
13,
23
]
} | {
"id": "C0022625",
"name": "ketoconazole",
"pos": [
230,
242
]
} |
different antimicrobial agents have shown different results and only tetracycline and erythromycin have shown consistent antibacterial properties . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial agents",
"pos": [
10,
30
]
} | {
"id": "C0039644",
"name": "tetracycline",
"pos": [
69,
81
]
} |
different antimicrobial agents have shown different results and only tetracycline and erythromycin have shown consistent antibacterial properties . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial agents",
"pos": [
10,
30
]
} | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
86,
98
]
} |
for comparative purposes , the effects of the tricyclic antidepressant desipramine ( 1.0-30 mg/kg ) and the antipsychotic haloperidol ( 0.03-0.3 mg/kg ) were similarly assessed . | therapeutic_class_of | {
"id": "C0040615",
"name": "antipsychotic",
"pos": [
108,
121
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
122,
133
]
} |
a compound ( compound x ) with antibacterial activity was isolated from early-exponential-phase cultures of the streptomycin producer streptomyces griseus and from protoplast cultures of the same strain . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
31,
44
]
} | {
"id": "C0038425",
"name": "streptomycin",
"pos": [
112,
124
]
} |
rat pups were treated with monoamine uptake inhibiting antidepressant drugs , desipramine , imipramine or nomifensine ( 5 mg/kg ) during the second and third postnatal weeks , and their later behavioral `` '' despair , '' '' measured by porsolt 's swim test , was examined . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant drugs",
"pos": [
55,
75
]
} | {
"id": "C0011685",
"name": "desipramine",
"pos": [
78,
89
]
} |
rat pups were treated with monoamine uptake inhibiting antidepressant drugs , desipramine , imipramine or nomifensine ( 5 mg/kg ) during the second and third postnatal weeks , and their later behavioral `` '' despair , '' '' measured by porsolt 's swim test , was examined . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant drugs",
"pos": [
55,
75
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
92,
102
]
} |
an automated gas chromatographic/mass spectrometric assay is described for the antiepileptic drug valproic acid ( vpa ) and 14 of its metabolites in plasma or urine . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drug",
"pos": [
79,
97
]
} | {
"id": "C0042291",
"name": "valproic acid",
"pos": [
98,
111
]
} |
the effects of oral administration of the neuroleptic , haloperidol , on regional brain concentrations of cholecystokinin ( cck ) and neurotensin were examined in the rat . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
42,
53
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
56,
67
]
} |
in vivo recordings with electrochemically modified microvoltammetric electrodes revealed that several neuroleptic drugs , including haloperidol , clozapine , and thioridazine , blocked the rise in extracellular ascorbate produced by amphetamine in the neostriatum of urethane-anesthetized rats . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic drugs",
"pos": [
102,
119
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
132,
143
]
} |
to attain complete rest it is advisable to administer as premedication a psychopharmaceutical preparation and the neuroleptic preparation haloperidol in adequate doses . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
114,
125
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
138,
149
]
} |
the synergistic activity of the combination cefotaxime-desacetylcefotaxime ( ctx/dctx ) was compared to the effectiveness of seven other antimicrobial agents : cefoxitin ( cfox ) , cefotetan ( ctan ) , ceftizoxime ( ctiz ) , chloramphenicol ( clor ) , clindamycin ( clind ) , metronidazole ( metr ) , and ampicillin-sulbactam ( a/s ) tested against 100 clinical isolates belonging to the bacteroides fragilis group . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial",
"pos": [
137,
150
]
} | {
"id": "C0025872",
"name": "metronidazole",
"pos": [
276,
289
]
} |
from the first report of the efficacy of the iodides for the treatment of sporotrichosis ( 1903 ) until the introduction of the imidazoles ( azoles , 1960s ) , the number of antifungal agents available was very limited , including griseofulvin ( 1939 ) , nystatin ( 1950 ) , amphotericin b ( 1956 ) , and flucytosine ( 1964 ) . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal agents",
"pos": [
174,
191
]
} | {
"id": "C0002679",
"name": "amphotericin b",
"pos": [
275,
289
]
} |
from the first report of the efficacy of the iodides for the treatment of sporotrichosis ( 1903 ) until the introduction of the imidazoles ( azoles , 1960s ) , the number of antifungal agents available was very limited , including griseofulvin ( 1939 ) , nystatin ( 1950 ) , amphotericin b ( 1956 ) , and flucytosine ( 1964 ) . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal agents",
"pos": [
174,
191
]
} | {
"id": "C0016278",
"name": "flucytosine",
"pos": [
305,
316
]
} |
these effects were not opposite to those of the antidepressant drug imipramine which decreased both 5-ht2 and beta-adrenoceptor density and did not alter alpha 1-adrenoceptor density . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant drug",
"pos": [
48,
67
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
68,
78
]
} |
these antidepressant-like effects of gnrh were similar to those observed with the tricyclic antidepressants imipramine ( 32 mg/kg per day ) or clomipramine ( 32 mg/kg per day ) in the same model . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
6,
20
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
108,
118
]
} |
these antidepressant-like effects of gnrh were similar to those observed with the tricyclic antidepressants imipramine ( 32 mg/kg per day ) or clomipramine ( 32 mg/kg per day ) in the same model . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
6,
20
]
} | {
"id": "C0009010",
"name": "clomipramine",
"pos": [
143,
155
]
} |
this evidence indicates that the antidepressant imipramine has a specific action in alleviating postpartum female aggression , and suggests that female aggression in mice is a useful tool for differentiating the actions of psychotropic drugs . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
33,
47
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
48,
58
]
} |
under antiepileptic therapy ( chiefly with phenytoin ) , the seizure frequency was slight ( not exceeding 2 per year in 3/4 of the patients ) . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic",
"pos": [
6,
19
]
} | {
"id": "C0031507",
"name": "phenytoin",
"pos": [
43,
52
]
} |
urinary excretion of the antiepileptic agent valproic acid ( vpa ) and major metabolites from its glucuronidation , beta-oxidation , and omega- and omega 1-hydroxylation pathways were studied under steady state conditions in 24 epileptic patients . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic agent",
"pos": [
25,
44
]
} | {
"id": "C0042291",
"name": "valproic acid",
"pos": [
45,
58
]
} |
antifungal treatment with fluconazole ( 2.5 to 20 mg/kg orally twice daily ) , itraconazole ( 10 to 40 mg/kg orally twice daily ) , or amphotericin b ( 0.1 to 4 mg/kg intraperitoneally once daily ) was started 1 day after intravenous injection of 10 ( 4 ) candida albicans into normal mice or 10 ( 3 ) c. albicans into neutropenic mice ; | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
0,
10
]
} | {
"id": "C0002679",
"name": "amphotericin b",
"pos": [
135,
149
]
} |
a single dose pharmacokinetic study of a combined antimalarial formulation of mefloquine , sulphadoxine and pyrimethamine ( fansimef ) has been performed in 10 healthy adult male malaysian volunteers . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial",
"pos": [
50,
62
]
} | {
"id": "C0025153",
"name": "mefloquine",
"pos": [
78,
88
]
} |
oxidation reactions of several other drugs , including the 5-hydroxylation of the new antiarrhythmic drug propafenone , depend on the isozyme responsible for debrisoquine 4-hydroxylation . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drug",
"pos": [
86,
105
]
} | {
"id": "C0033429",
"name": "propafenone",
"pos": [
106,
117
]
} |
a nuclear magnetic resonance study of the interactions of the antimalarials chloroquine , quinacrine , quinine and mefloquine with lipids extracted from normal human erythrocytes . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarials",
"pos": [
62,
75
]
} | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
76,
87
]
} |
a nuclear magnetic resonance study of the interactions of the antimalarials chloroquine , quinacrine , quinine and mefloquine with lipids extracted from normal human erythrocytes . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarials",
"pos": [
62,
75
]
} | {
"id": "C0025153",
"name": "mefloquine",
"pos": [
115,
125
]
} |
the interaction of four antimalarials ( chloroquine , quinacrine , mefloquine and quinine ) with lipid membranes re-formed from lipid extracts of normal human erythrocytes was studied using 2h- and lipid extracts of normal human erythrocytes was studied using 2h- and 31p-nuclear magnetic resonance ( nmr ) . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarials",
"pos": [
24,
37
]
} | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
40,
51
]
} |
the interaction of four antimalarials ( chloroquine , quinacrine , mefloquine and quinine ) with lipid membranes re-formed from lipid extracts of normal human erythrocytes was studied using 2h- and lipid extracts of normal human erythrocytes was studied using 2h- and 31p-nuclear magnetic resonance ( nmr ) . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarials",
"pos": [
24,
37
]
} | {
"id": "C0025153",
"name": "mefloquine",
"pos": [
67,
77
]
} |
four experiments were carried out investigating the interactions between some antidepressant drugs ( imipramine , desipramine , fluvoxamine , trazodone ( 4 and 8 mg/kg ) and d-amphetamine ( 0.1-3.2 mg/kg ) on operant behaviour maintained under a variable-interval 80-s schedule of sucrose reinforcement ; | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant drugs",
"pos": [
78,
98
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
101,
111
]
} |
four experiments were carried out investigating the interactions between some antidepressant drugs ( imipramine , desipramine , fluvoxamine , trazodone ( 4 and 8 mg/kg ) and d-amphetamine ( 0.1-3.2 mg/kg ) on operant behaviour maintained under a variable-interval 80-s schedule of sucrose reinforcement ; | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant drugs",
"pos": [
78,
98
]
} | {
"id": "C0011685",
"name": "desipramine",
"pos": [
114,
125
]
} |
new preparations of the drug , such as liposomal amphotericin b , may also prove useful in minimising nephrotoxicity while maintaining antifungal activity , but further research is needed with both salt loading and liposomal amphotericin b to confirm or deny their protective effect on kidney function . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
135,
145
]
} | {
"id": "C1145701",
"name": "liposomal amphotericin b",
"pos": [
215,
239
]
} |
when the paroxysmal forms of arrhythmia are resistant to usual pure antiarrhythmic therapy including type ia agents and flecainide or encainide , one should take into account the role of the autonomic nervous system . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
68,
82
]
} | {
"id": "C0016229",
"name": "flecainide",
"pos": [
120,
130
]
} |
it is concluded that this strategy would be of potential value for tricyclic antidepressants , some neuroleptics ( e.g . perphenazine and thioridazine ) and some anti-arrhythmics ( e.g . propafenone and flecainide ) . | therapeutic_class_of | {
"id": "C0003195",
"name": "anti-arrhythmics",
"pos": [
162,
178
]
} | {
"id": "C0033429",
"name": "propafenone",
"pos": [
187,
198
]
} |
it is concluded that this strategy would be of potential value for tricyclic antidepressants , some neuroleptics ( e.g . perphenazine and thioridazine ) and some anti-arrhythmics ( e.g . propafenone and flecainide ) . | therapeutic_class_of | {
"id": "C0003195",
"name": "anti-arrhythmics",
"pos": [
162,
178
]
} | {
"id": "C0016229",
"name": "flecainide",
"pos": [
203,
213
]
} |
six groups of drugs used as anti-inflammatory/antirheumatic agents have been discussed in association with pulmonary damage penicillamine , gold , methotrexate , salicylates , nsaids , and colchicine . | therapeutic_class_of | {
"id": "C0003191",
"name": "antirheumatic agents",
"pos": [
46,
66
]
} | {
"id": "C0030817",
"name": "penicillamine",
"pos": [
124,
137
]
} |
the two drugs antagonists at these receptors , were studied for their ability to modify the effect of repeated treatment with the antidepressant , desipramine in the forced swimming test . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
130,
144
]
} | {
"id": "C0011685",
"name": "desipramine",
"pos": [
147,
158
]
} |
the authors present a series of cases demonstrating that some chronically psychotic patients require higher doses of antipsychotic medication ( greater than 15 mg/day of haloperidol equivalents ) than are currently in vogue as a result of research on low-dose treatment . | therapeutic_class_of | {
"id": "C0040615",
"name": "antipsychotic medication",
"pos": [
117,
141
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
170,
181
]
} |
we examined the value of the melancholic distinction for predicting response to 1 week of hospitalization without antidepressant drugs and to a 4-week fixed plasma level desipramine ( dmi ) trial in patients with unipolar non-psychotic major depression . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant drugs",
"pos": [
114,
134
]
} | {
"id": "C0011685",
"name": "desipramine",
"pos": [
170,
181
]
} |
although theoretically the spectrum of antimicrobial quinolone antibiotics are at low risk of producing clostridium difficile overgrowth and diarrhea , a patient developed this clinical problem while receiving norfloxacin . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial",
"pos": [
39,
52
]
} | {
"id": "C0028365",
"name": "norfloxacin",
"pos": [
210,
221
]
} |
we now describe a stereoselective analytical method for the determination of the antiarrhythmic agent flecainide in plasma . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agent",
"pos": [
81,
101
]
} | {
"id": "C0016229",
"name": "flecainide",
"pos": [
102,
112
]
} |
these results suggest that megx has a lidocaine-like class i antiarrhythmic actions and that it might modify the actions of lidocaine especially in patients with elevated plasma megx concentration . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
61,
75
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
124,
133
]
} |
the specific ( high-affinity ) binding of tritiated benzimidazole [ ( 3h ] bz ) anthelmintics-mebendazole [ ( 3h ] mbz ) and oxibendazole [ ( 3h ] obz ) to , and the specific displacement ( inhibition ) of these radioligands by unlabelled bzs ( oxibendazole , mebendazole , oxfendazole , albendazole , fenbendazole and thiabendazole ) from crude tubulin extracts prepared from thiabendazole ( tbz ) -susceptible ( s ) or tbz-resistant ( r ) strains of adult haemonchus contortus , have been examined . | therapeutic_class_of | {
"id": "C0003158",
"name": "anthelmintics",
"pos": [
80,
93
]
} | {
"id": "C0025023",
"name": "mebendazole",
"pos": [
260,
271
]
} |
the specific ( high-affinity ) binding of tritiated benzimidazole [ ( 3h ] bz ) anthelmintics-mebendazole [ ( 3h ] mbz ) and oxibendazole [ ( 3h ] obz ) to , and the specific displacement ( inhibition ) of these radioligands by unlabelled bzs ( oxibendazole , mebendazole , oxfendazole , albendazole , fenbendazole and thiabendazole ) from crude tubulin extracts prepared from thiabendazole ( tbz ) -susceptible ( s ) or tbz-resistant ( r ) strains of adult haemonchus contortus , have been examined . | therapeutic_class_of | {
"id": "C0003158",
"name": "anthelmintics",
"pos": [
80,
93
]
} | {
"id": "C0001911",
"name": "albendazole",
"pos": [
288,
299
]
} |
this class of antifungal agents is represented by the marketed drug ketoconazole ( nizoral ) and the experimental triazoles furthest along in clinical trials in the united states , itraconazole and fluconazole . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
14,
24
]
} | {
"id": "C0022625",
"name": "ketoconazole",
"pos": [
68,
80
]
} |
we have replicated the findings of mirmiran and colleagues that neonatal administration of the antidepressant clomipramine ( cli ) to male rats results in hyperactivity in open-field tests in adulthood . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
95,
109
]
} | {
"id": "C0009010",
"name": "clomipramine",
"pos": [
110,
122
]
} |
preliminary evidence suggested that behavioral abnormalities in rats ( sexual , aggressive , and motor ) briefly treated with antidepressant treatments ( imipramine , rem sleep deprivation ) begin to normalize . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
126,
140
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
154,
164
]
} |
preliminary data from investigations using a newly developed antiseptic , octenidine , a bispyridine compound , demonstrate reduction factors comparable to those obtained by pvp-iodine . | therapeutic_class_of | {
"id": "C0003205",
"name": "antiseptic",
"pos": [
61,
71
]
} | {
"id": "C0032857",
"name": "pvp-iodine",
"pos": [
174,
184
]
} |
disturbances of the topographical distribution of theta activity in the eeg spectra before and during voluntary movements were investigated in 31 neuroleptic-treated and in 13 untreated schizophrenics and matched controls as well as in 15 normals medicated with haloperidol . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
146,
157
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
262,
273
]
} |
since beclamide ( beta-chlorpropionamide ) was reported to reduce the neuroleptic doses required , the combination haloperidol-beclamide was tested using a double-blind , placebo-controlled study in 23 inpatients with an acute schizophrenic psychosis . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
70,
81
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
115,
126
]
} |
we investigated the influence of five antifungal agents on pmn function and compared them with amphotericin b ( amb ) . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal agents",
"pos": [
38,
55
]
} | {
"id": "C0002679",
"name": "amphotericin b",
"pos": [
95,
109
]
} |
there were no significant differences in efficacy among any of the combinations of antimicrobial agents that included ciprofloxacin or rifampin . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial agents",
"pos": [
83,
103
]
} | {
"id": "C0008809",
"name": "ciprofloxacin",
"pos": [
118,
131
]
} |
the antibacterial spectrum of activity of piperacillin was compared with that of other antibiotics against isolates of escherichia coli , enterobacter cloacae , haemophilus influenzae , klebsiella pneumoniae , pseudomonas aeruginosa , pseudomonas cepacia , pseudomonas maltophilia , serratia marcescens , enterococcus sp , bacteroides fragilis , bacteroides bivius , and clostridium difficile obtained from laboratories at hospitals in st . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0031955",
"name": "piperacillin",
"pos": [
42,
54
]
} |
clavulanic acid enhances the antibacterial spectrum of amoxicillin by rendering most beta-lactamase-producing isolates susceptible to the drug . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
29,
42
]
} | {
"id": "C0002645",
"name": "amoxicillin",
"pos": [
55,
66
]
} |
heart failure in fetuses may occur from sustained supraventricular tachyarrhythmias , and may respond to treatment of the mother with antiarrhythmic agents such as digoxin or procainamide . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agents",
"pos": [
134,
155
]
} | {
"id": "C0033216",
"name": "procainamide",
"pos": [
175,
187
]
} |
in the second group , addition of valpromide resulted in a significant increase of antidepressant plasma levels : from 70.5 +/- 35 to 105.5 +/- 49 ng/ml ( p less than 0.0003 ) for amitriptyline , and from 61.0 +/- 34 to 100.5 +/- 65 ng/ml ( p less than 0.01 ) for nortriptyline . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
83,
97
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
180,
193
]
} |
in the second group , addition of valpromide resulted in a significant increase of antidepressant plasma levels : from 70.5 +/- 35 to 105.5 +/- 49 ng/ml ( p less than 0.0003 ) for amitriptyline , and from 61.0 +/- 34 to 100.5 +/- 65 ng/ml ( p less than 0.01 ) for nortriptyline . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
83,
97
]
} | {
"id": "C0028420",
"name": "nortriptyline",
"pos": [
264,
277
]
} |
after treatment , antiarrhythmic therapy ( amiodarone 200 mg/day ) was continued for all patients , although at a lower dose than before fulguration . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
18,
32
]
} | {
"id": "C0002598",
"name": "amiodarone",
"pos": [
43,
53
]
} |
within 9 days of the discontinuation of antimicrobial treatment , c jejuni was isolated from all chloramphenicol-treated dogs and 89 % erythromycin-treated dogs . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial",
"pos": [
40,
53
]
} | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
135,
147
]
} |
type 1a antiarrhythmic drugs achieved long-term suppression of intraatrial reentrant tachycardia in only 6 patients , whereas amiodarone ( 326 +/- 145 mg/day ) was successful in 11 patients during a 32 +/- 20 month follow-up period . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drugs",
"pos": [
8,
28
]
} | {
"id": "C0002598",
"name": "amiodarone",
"pos": [
126,
136
]
} |
this arrhythmia responds poorly to type 1a antiarrhythmic drugs , but is effectively treated with amiodarone . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drugs",
"pos": [
43,
63
]
} | {
"id": "C0002598",
"name": "amiodarone",
"pos": [
98,
108
]
} |
their in vitro and in vivo antibacterial activities in comparison with rifampicin and two other rifamycins under investigation were evaluated . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
27,
40
]
} | {
"id": "C0035608",
"name": "rifampicin",
"pos": [
71,
81
]
} |
2 shows 8-fold increased antimalarial activity in vitro against chloroquine-resistant malaria as compared to artemisinin ( 1 ) . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial",
"pos": [
25,
37
]
} | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
64,
75
]
} |
this randomized double-blind study evaluates systemic antifungal therapy with fluconazole ( 100 mg daily ) or ketoconazole ( 400-mg daily ) for oropharyngeal candidiasis in patients with cancer . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
54,
64
]
} | {
"id": "C0022625",
"name": "ketoconazole",
"pos": [
110,
122
]
} |
clinical experience has shown that the antiarrhythmic effect of lidocaine on atrial arrhythmias , and specifically for the conversion of atrial fibrillation to normal sinus rhythm , is minimal . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
39,
53
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
64,
73
]
} |
the cardioprotective effects of antiarrhythmic agents classified as class iii , amiodarone , sotalol and e-4031 , were investigated in anaesthetized dogs . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agents",
"pos": [
32,
53
]
} | {
"id": "C0002598",
"name": "amiodarone",
"pos": [
80,
90
]
} |
the cardioprotective effects of antiarrhythmic agents classified as class iii , amiodarone , sotalol and e-4031 , were investigated in anaesthetized dogs . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agents",
"pos": [
32,
53
]
} | {
"id": "C0037707",
"name": "sotalol",
"pos": [
93,
100
]
} |
the effects of terconazole , a triazole antifungal , on the sterol and carbohydrate composition of candida albicans was compared with that of three imidazoles : clotrimazole , miconazole , and butoconazole . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
40,
50
]
} | {
"id": "C0025942",
"name": "miconazole",
"pos": [
176,
186
]
} |
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