text
stringlengths 57
1.72k
| relation
stringclasses 125
values | h
dict | t
dict |
|---|---|---|---|
these investigations were repeated during 67 trials of oral antiarrhythmic therapy ( mexiletine 25 , quinidine 24 , metoprolol 13 , disopyramide 2 , procainamide 1 , drug combinations 2 ) . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
60,
74
]
} | {
"id": "C0012702",
"name": "disopyramide",
"pos": [
132,
144
]
} |
these investigations were repeated during 67 trials of oral antiarrhythmic therapy ( mexiletine 25 , quinidine 24 , metoprolol 13 , disopyramide 2 , procainamide 1 , drug combinations 2 ) . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
60,
74
]
} | {
"id": "C0033216",
"name": "procainamide",
"pos": [
149,
161
]
} |
disopyramide is an antiarrhythmic drug similar to quinidine and used primarily to treat ventricular ectopic systoles . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drug",
"pos": [
19,
38
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
50,
59
]
} |
acute administration of the antidepressant drug desipramine ( dmi ) in man , increased evening melatonin secretion , which reached peak plasma levels 2-4 h earlier than after placebo administration . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
28,
42
]
} | {
"id": "C0011685",
"name": "desipramine",
"pos": [
48,
59
]
} |
all patients had coronary artery disease and were receiving antiarrhythmic drug therapy ( amiodarone in eight ) . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drug",
"pos": [
60,
79
]
} | {
"id": "C0002598",
"name": "amiodarone",
"pos": [
90,
100
]
} |
the number of muscarinic cholinergic-binding sites and the specific activity of choline acetyltransferase were found to be significantly increased by prenatal treatment with the neuroleptics haloperidol or ( + ) -butaclamol . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
178,
190
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
191,
202
]
} |
the antiarrhythmic efficacy of propafenone ( pf ) was evaluated in 24 patients with ventricular hyperkinetic arrhythmias by means of 24-hour holter monitoring . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
4,
18
]
} | {
"id": "C0033429",
"name": "propafenone",
"pos": [
31,
42
]
} |
[ evaluation of the hemodynamic effects and anti-arrhythmic activity of propafenone : from new frontiers to clinical verification ] . | therapeutic_class_of | {
"id": "C0003195",
"name": "anti-arrhythmic",
"pos": [
44,
59
]
} | {
"id": "C0033429",
"name": "propafenone",
"pos": [
72,
83
]
} |
two applications are reported on : ( 1 ) the direct injection of serum samples for the simultaneous analysis of nine antiepileptic drugs and metabolites and ( 2 ) the determination of phenytoin and of carbamazepine in serum ultra-filtrates . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drugs",
"pos": [
117,
136
]
} | {
"id": "C0031507",
"name": "phenytoin",
"pos": [
184,
193
]
} |
owing to the high broad-spectrum antifungal activity of clotrimazole and econazole , they should be the treatment of choice in otomycosis and can be used safely as otic drops . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
33,
43
]
} | {
"id": "C0013547",
"name": "econazole",
"pos": [
73,
82
]
} |
low , reproducible minimal inhibitory concentrations against candida species , with sharp , precise end points in complex media were achieved for imidazoles ( clotrimazole , econazole , miconazole , tioconazole and ketoconazole ) and triazoles ( fluconazole , itraconazole , vibunazole , ici 153066 ) by including in the test medium antibacterial antibiotics that bind to the 80s eukaryotic ribosome and inhibit protein synthesis , i.e . blasticidin , cycloheximide , doxycycline , neomycin and gentamicin . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
333,
346
]
} | {
"id": "C0027603",
"name": "neomycin",
"pos": [
482,
490
]
} |
acute administration of the antipsychotic drug haloperidol causes an increase in the firing rate and in the proportion of spontaneously active dopamine neurons in the substantia nigra . | therapeutic_class_of | {
"id": "C0040615",
"name": "antipsychotic",
"pos": [
28,
41
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
47,
58
]
} |
in the rat uterus , the calcium channel antagonists , nitrendipine and diltiazem , and the neuroleptic agents , trifluoperazine ( tfp ) and pimozide , antagonized potently and noncompetitively 5-ht-induced contractions . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic agents",
"pos": [
91,
109
]
} | {
"id": "C0031935",
"name": "pimozide",
"pos": [
140,
148
]
} |
unlike known antipsychotics neither 25 nor 38 elicited dystonic movements in haloperidol-sensitized cebus monkeys , a primate model of antipsychotic-induced extrapyramidal side effects . | therapeutic_class_of | {
"id": "C0040615",
"name": "antipsychotics",
"pos": [
13,
27
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
77,
88
]
} |
the antimalarial effect of intravenously administered primaquine ( pq ) can be improved and its toxicity diminished by linking it to a macromolecular carrier protein . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial",
"pos": [
4,
16
]
} | {
"id": "C0033126",
"name": "primaquine",
"pos": [
54,
64
]
} |
to further assess this enhanced antiarrhythmic effect , the electrophysiologic actions of mexiletine and quinidine alone and in combination were evaluated in isolated perfused rabbit hearts . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
32,
46
]
} | {
"id": "C0025887",
"name": "mexiletine",
"pos": [
90,
100
]
} |
to further assess this enhanced antiarrhythmic effect , the electrophysiologic actions of mexiletine and quinidine alone and in combination were evaluated in isolated perfused rabbit hearts . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
32,
46
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
105,
114
]
} |
to assess the electrophysiologic correlates of this enhanced antiarrhythmic effect , concentration-response relationships of mexiletine and quinidine alone and in combination were evaluated in 117 isolated perfused rabbit hearts after circumflex occlusion-reperfusion . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
61,
75
]
} | {
"id": "C0025887",
"name": "mexiletine",
"pos": [
125,
135
]
} |
to assess the electrophysiologic correlates of this enhanced antiarrhythmic effect , concentration-response relationships of mexiletine and quinidine alone and in combination were evaluated in 117 isolated perfused rabbit hearts after circumflex occlusion-reperfusion . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
61,
75
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
140,
149
]
} |
the anti-arrhythmic quinidine has been reported to be a competitive inhibitor of the catalytic activities of human liver p-450db , including sparteine delta 2-oxidation and bufuralol 1'-hydroxylation , and we confirmed the observation that submicromolar concentrations are strongly inhibitory . | therapeutic_class_of | {
"id": "C0003195",
"name": "anti-arrhythmic",
"pos": [
4,
19
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
20,
29
]
} |
the n gonorrhoeae strains were highly susceptible to 11 other antibacterial drugs but not to sulphadiazine . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial drugs",
"pos": [
62,
81
]
} | {
"id": "C0038675",
"name": "sulphadiazine",
"pos": [
93,
106
]
} |
the redox dyes methyl viologen and phenosafranine inhibited ic production more severely than iv production , as did the nitroimidazole antimicrobial agent , metronidazole . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial agent",
"pos": [
135,
154
]
} | {
"id": "C0025872",
"name": "metronidazole",
"pos": [
157,
170
]
} |
we studied the antiarrhythmic effects of amiodarone , 600-1400 mg/day , in 18 patients with refractory arrhythmias , and related to drug efficacy and side effects to serum levels of t4 , reverse t3 ( rt3 ) and the qtc interval . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
15,
29
]
} | {
"id": "C0002598",
"name": "amiodarone",
"pos": [
41,
51
]
} |
a number of compounds ( iv ) and ( v ) showed remarkable hypotensive and bradycardic activity in rats , whereas ( iv c ) showed infiltration anesthesia and ( iv n ) antiarrhythmic activity in mice comparable to those of lidocaine . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
165,
179
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
220,
229
]
} |
the order of potency of the antidepressant drugs for producing response rate increases ( i.e. , amitriptyline greater than imipramine greater than desmethylimipramine ) is the same as that reported by others for the affinity of these drugs for muscarinic binding sites in rat brain . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
28,
42
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
96,
109
]
} |
the order of potency of the antidepressant drugs for producing response rate increases ( i.e. , amitriptyline greater than imipramine greater than desmethylimipramine ) is the same as that reported by others for the affinity of these drugs for muscarinic binding sites in rat brain . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
28,
42
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
156,
166
]
} |
the order of potency of the antidepressant drugs for producing response rate increases ( i.e. , amitriptyline greater than imipramine greater than desmethylimipramine ) is the same as that reported by others for the affinity of these drugs for muscarinic binding sites in rat brain . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
28,
42
]
} | {
"id": "C0011685",
"name": "desmethylimipramine",
"pos": [
147,
166
]
} |
our results suggested that the in vivo antibacterial effect to vancomycin could be enhanced by prolonged infusion . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
39,
52
]
} | {
"id": "C0042313",
"name": "vancomycin",
"pos": [
63,
73
]
} |
the antibacterial activities of ctt were bactericidal and were little affected by addition of horse serum and by variation in ph of the medium , in inoculum size and in type of culture media . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0007555",
"name": "ctt",
"pos": [
32,
35
]
} |
therefore : ( a ) canine models for studying the antiarrhythmic actions of commercial intravenous amiodarone would produce results complicated by severe hypotension ; | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
49,
63
]
} | {
"id": "C0002598",
"name": "amiodarone",
"pos": [
98,
108
]
} |
the trial confirms that mianserin has an antidepressant effect similar to that of chlorimipramine with fewer side effects . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
41,
55
]
} | {
"id": "C0009010",
"name": "chlorimipramine",
"pos": [
82,
97
]
} |
zimelidine had the same antidepressant efficacy as amitriptyline but significantly fewer side effects , especially anticholinergic effects . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
24,
38
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
51,
64
]
} |
we compared fia and the well-established antiepileptic drug immunoassay technique emit for the quantitation of both carbamazepine and primidone . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drug",
"pos": [
41,
59
]
} | {
"id": "C0033148",
"name": "primidone",
"pos": [
134,
143
]
} |
the first group includes the antidepressants ( melipramine , chlorimipramine , lu 5-003 , lu 3-010 , s-394 , pyrazidol ) that have a ratio close to i and in whose mechanism of aminopotentiating action the main component is unlikely to be distinguished . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
29,
44
]
} | {
"id": "C0009010",
"name": "chlorimipramine",
"pos": [
61,
76
]
} |
as to the 3d group antidepressants ( thyroliberin , iprindol , noveril , c-356 , c-395 , amitryptyline ) , of great importance is their effect on the presynaptic neurotransmitter release from the terminals of the axons of noradrenergic neurons . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
19,
34
]
} | {
"id": "C0002600",
"name": "amitryptyline",
"pos": [
89,
102
]
} |
bacteriological responses coincided with the problems of the patient but did not reflect inadequacy of the antibacterial effect of cefoperazone . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
107,
120
]
} | {
"id": "C0007552",
"name": "cefoperazone",
"pos": [
131,
143
]
} |
the responsiveness of the frequent ventricular premature contractions to the antiarrhythmic effects of quinidine and lignocaine was tested in twelve preparations . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
77,
91
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
103,
112
]
} |
the responsiveness of the frequent ventricular premature contractions to the antiarrhythmic effects of quinidine and lignocaine was tested in twelve preparations . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
77,
91
]
} | {
"id": "C0023660",
"name": "lignocaine",
"pos": [
117,
127
]
} |
the importance of variation in plasma binding in the uncertain correlation between total plasma concentration and the antidepressive effect of amitriptyline ( at ) and its active metabolite nortriptyline ( nt ) was examined . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressive",
"pos": [
118,
132
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
143,
156
]
} |
the importance of variation in plasma binding in the uncertain correlation between total plasma concentration and the antidepressive effect of amitriptyline ( at ) and its active metabolite nortriptyline ( nt ) was examined . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressive",
"pos": [
118,
132
]
} | {
"id": "C0028420",
"name": "nortriptyline",
"pos": [
190,
203
]
} |
the in vitro combined antifungal activity of amphotericin b ( amb ) and 5-fluorocytosine ( 5-fc ) against 10 strains of candida albicans and 8 strains of cryptococcus neoformans was studied . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
22,
32
]
} | {
"id": "C0002679",
"name": "amphotericin b",
"pos": [
45,
59
]
} |
the in vitro combined antifungal activity of amphotericin b ( amb ) and 5-fluorocytosine ( 5-fc ) against 10 strains of candida albicans and 8 strains of cryptococcus neoformans was studied . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
22,
32
]
} | {
"id": "C0016278",
"name": "5-fc",
"pos": [
91,
95
]
} |
the following antiepileptics were tested for the anticonvulsant effects both in naive and ka-lesioned mice : phenobarbital ( 20 mg/kg ) , diazepam ( 8 mg/kg ) , carbamazepine ( 15 mg/kg ) and diphenylhydantoin ( 10 mg/kg ) , all drugs being injected intraperitoneally 60 min before electroconvulsions . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptics",
"pos": [
14,
28
]
} | {
"id": "C0031507",
"name": "diphenylhydantoin",
"pos": [
192,
209
]
} |
the antibacterial activity of the newer beta-lactam compounds mezlocillin , cefuroxime , cefotaxime , ceftizoxime , cefoperazone , lamoxactam , and cefsulodin was evaluated in 335 strains of ampicillin-resistant ( mic greater than 16 mg/l ) enterobacteria , 50 pseudomonas aeruginosa , 28 acinetobacter species , and 50 streptococcus faecalis isolates . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0007562",
"name": "cefuroxime",
"pos": [
76,
86
]
} |
the antibacterial activity of the newer beta-lactam compounds mezlocillin , cefuroxime , cefotaxime , ceftizoxime , cefoperazone , lamoxactam , and cefsulodin was evaluated in 335 strains of ampicillin-resistant ( mic greater than 16 mg/l ) enterobacteria , 50 pseudomonas aeruginosa , 28 acinetobacter species , and 50 streptococcus faecalis isolates . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
89,
99
]
} |
the antibacterial activity of the newer beta-lactam compounds mezlocillin , cefuroxime , cefotaxime , ceftizoxime , cefoperazone , lamoxactam , and cefsulodin was evaluated in 335 strains of ampicillin-resistant ( mic greater than 16 mg/l ) enterobacteria , 50 pseudomonas aeruginosa , 28 acinetobacter species , and 50 streptococcus faecalis isolates . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0007560",
"name": "ceftizoxime",
"pos": [
102,
113
]
} |
the antibacterial activity of the newer beta-lactam compounds mezlocillin , cefuroxime , cefotaxime , ceftizoxime , cefoperazone , lamoxactam , and cefsulodin was evaluated in 335 strains of ampicillin-resistant ( mic greater than 16 mg/l ) enterobacteria , 50 pseudomonas aeruginosa , 28 acinetobacter species , and 50 streptococcus faecalis isolates . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0007552",
"name": "cefoperazone",
"pos": [
116,
128
]
} |
the antibacterial activity of the newer beta-lactam compounds mezlocillin , cefuroxime , cefotaxime , ceftizoxime , cefoperazone , lamoxactam , and cefsulodin was evaluated in 335 strains of ampicillin-resistant ( mic greater than 16 mg/l ) enterobacteria , 50 pseudomonas aeruginosa , 28 acinetobacter species , and 50 streptococcus faecalis isolates . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
191,
201
]
} |
nine antimicrobial agents , including ampicillin , carbenicillin , cephalothin , gentamicin , tobramycin , amikacin , tetracycline , trimethoprim-sulfamethoxazole , and nitrofurantoin were tested . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial agents",
"pos": [
5,
25
]
} | {
"id": "C0039644",
"name": "tetracycline",
"pos": [
118,
130
]
} |
endocavitary fulguration was performed in 31 cases of high-risk ventricular tachycardia ( vt ) for which antiarrhythmics , including amiodarone and class-i antiarrhythmic agents , given alone or in combination , proved ineffective . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmics",
"pos": [
105,
120
]
} | {
"id": "C0002598",
"name": "amiodarone",
"pos": [
133,
143
]
} |
the sensitivity of alpha 2-adrenoceptors on 5-hydroxytryptamine ( 5-ht ) nerve endings obtained from rat cerebral cortex was investigated following treatment with the antidepressant drugs desipramine ( 10 mg/kg/day for 21-28 days ) or clorgyline ( 1 mg/kg/day for 21-28 days ) . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
167,
181
]
} | {
"id": "C0011685",
"name": "desipramine",
"pos": [
188,
199
]
} |
these findings suggest that a prolongation of the qt interval may be a marker for the therapeutic antiarrhythmic effect of amiodarone . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
98,
112
]
} | {
"id": "C0002598",
"name": "amiodarone",
"pos": [
123,
133
]
} |
acetylation is the major route of metabolism of many drugs including the antiarrhythmic agent procainamide . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agent",
"pos": [
73,
93
]
} | {
"id": "C0033216",
"name": "procainamide",
"pos": [
94,
106
]
} |
the antiarrhythmic efficacy and safety of oral encainide hydrochloride and quinidine sulfate were compared in a nine center double-blind crossover study in 187 outpatients with benign or potentially lethal ventricular arrhythmias . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
4,
18
]
} | {
"id": "C0034415",
"name": "quinidine sulfate",
"pos": [
75,
92
]
} |
treatment with conventional antiarrhythmic therapy was unsuccessful in all but 1 patient , and 10 patients were treated with amiodarone and 1 patient with propafenone . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
28,
42
]
} | {
"id": "C0002598",
"name": "amiodarone",
"pos": [
125,
135
]
} |
treatment with conventional antiarrhythmic therapy was unsuccessful in all but 1 patient , and 10 patients were treated with amiodarone and 1 patient with propafenone . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
28,
42
]
} | {
"id": "C0033429",
"name": "propafenone",
"pos": [
155,
166
]
} |
excluding patients with possible panic-phobic syndromes from the analyses removed most significant antiphobic and antidepressant effects of imipramine but left intact imipramine 's significantly superior antianxiety effects . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
114,
128
]
} | {
"id": "C0020934",
"name": "imipramine 's",
"pos": [
167,
180
]
} |
all neuroleptics tested ( haloperidol , sulpiride , flupentixol decanoate , perphenazine enanthate , fluphenazine decanoate , palmitic ester of pipotiazine ) induced a marked behavioral supersensitivity to intraaccumbens opiate infusion . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
4,
16
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
26,
37
]
} |
the effect of the antiepileptic drug phenytoin ( diphenylhydantoin , dph ) was tested on the conduction of intracellularly recorded action potentials in lamprey giant reticulospinal axons . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic",
"pos": [
18,
31
]
} | {
"id": "C0031507",
"name": "diphenylhydantoin",
"pos": [
49,
66
]
} |
analgesic and antidepressive effects of low-dose amitriptyline in relation to its metabolism in patients with chronic pain . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressive",
"pos": [
14,
28
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
49,
62
]
} |
the analgesic and antidepressive effects of amitriptyline ( at ) in relation to its kinetics and metabolism were studied in 19 outpatients with chronic pain who received a daily dose of 75 mg at for at least 6 weeks . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressive",
"pos": [
18,
32
]
} | {
"id": "C0002600",
"name": "at",
"pos": [
199,
201
]
} |
the antimalarials used for the therapy of porphyria cutanea tarda , chloroquine and pyrimethamine , reduced the total synthesis of porphyrins , pyrimethamine being more effective than chloroquine , like in porphyric patients . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarials",
"pos": [
4,
17
]
} | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
184,
195
]
} |
the purpose of this study was to determine the effect of the antiarrhythmic drugs lidocaine and bretylium on the minimal energy requirement for transthoracic defibrillation -- the defibrillation threshold . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
61,
75
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
82,
91
]
} |
because administration of sodium sulfate also reportedly decreases aa-induced toxicity , we have investigated the role of inorganic sulfate in the antidotal properties of nac . | therapeutic_class_of | {
"id": "C0003295",
"name": "antidotal",
"pos": [
147,
156
]
} | {
"id": "C0001047",
"name": "nac",
"pos": [
171,
174
]
} |
all four enantiomers exhibited effects on end-plate current and miniature end-plate current decay at similar concentrations ( 0.2-1.0 mm ) , indicating that the measured effect was not related to the antibacterial action of the compounds in which d-threo chloramphenicol is known to be at least 50 times more powerful than the l-threo and d- and l-erythro isomers . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
200,
213
]
} | {
"id": "C0008168",
"name": "chloramphenicol",
"pos": [
255,
270
]
} |
kinetic , circular dichroism , and nadh and nadph fluorescence quenching studies indicate that these compounds interact with the antimalarial drug primaquine ( pq ) . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial drug",
"pos": [
129,
146
]
} | {
"id": "C0033126",
"name": "primaquine",
"pos": [
147,
157
]
} |
a synergistic antibacterial effect was observed when organisms were exposed to cephalothin and oxacillin in combination , and the resistance of even very small inocula to cephalothin was reduced by addition of oxacillin . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
14,
27
]
} | {
"id": "C0029983",
"name": "oxacillin",
"pos": [
210,
219
]
} |
a 61-year-old woman with severe rheumatoid arthritis developed bullous lesions on the trunk , conjunctiva , and oral mucosa during treatment with tiobutarit , a new antirheumatic drug analogus to d-penicillamine . | therapeutic_class_of | {
"id": "C0003191",
"name": "antirheumatic drug",
"pos": [
165,
183
]
} | {
"id": "C0030817",
"name": "penicillamine",
"pos": [
198,
211
]
} |
dfo combined with fe3+ at greater than or equal to 0.1 mmol decreased the antifungal activity of amphotericin b in vitro . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
74,
84
]
} | {
"id": "C0002679",
"name": "amphotericin b",
"pos": [
97,
111
]
} |
to elucidate the molecular mechanism underlying the adverse depression of myocardial contractility observed during antiarrhythmic therapy of quinidine , we investigated its action on the phosphatidylethanolamine n-methyltransferase ( ec 2.1.1.17 ) activities of cardiac subcellular membranes . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
115,
129
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
141,
150
]
} |
neuroleptics , such as haloperidol , have been found to produce dysphoria , anxiety and akathisia in humans . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
0,
12
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
23,
34
]
} |
in male rats , defecation was measured for a one hour test period following various doses of the neuroleptic , pimozide , and the dopamine receptor agonist , apomorphine . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
97,
108
]
} | {
"id": "C0031935",
"name": "pimozide",
"pos": [
111,
119
]
} |
analysis of the relationship between clinical outcome and various treatment strategies in cases reported in the literature and in our own showed that an initial trial of antifungal drugs consisting of oral ketoconazole and i.p . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal drugs",
"pos": [
170,
186
]
} | {
"id": "C0022625",
"name": "ketoconazole",
"pos": [
206,
218
]
} |
new modalities of antifungal therapy are extensively evaluated , including various preparations of liposomal amphotericin b and promising new agents such as itraconazole and fluconazole . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
18,
28
]
} | {
"id": "C1145701",
"name": "liposomal amphotericin b",
"pos": [
99,
123
]
} |
three reference anthelminthics -- pyrantel ( pytl ) , mebendazole ( mbz ) and ivermectin ( ivrn ) -- were used to assess the sensitivity of adult n. americanus and also to investigate the value of the hamster-hookworm model for predicting clinical results . | therapeutic_class_of | {
"id": "C0003158",
"name": "anthelminthics",
"pos": [
16,
30
]
} | {
"id": "C0025023",
"name": "mebendazole",
"pos": [
54,
65
]
} |
since recent in vivo evidence suggests that the benzofuran antiarrhythmic drug amiodarone has a direct toxic effect on the human thyroid gland , we have investigated the effects of both amiodarone and its metabolite desethylamiodarone on a novel immortalized functional human thyrocyte line ( sghtl-34 cells ) . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drug",
"pos": [
59,
78
]
} | {
"id": "C0002598",
"name": "amiodarone",
"pos": [
224,
234
]
} |
the new molecules ( p-1368 , p-1370 ) , evaluated in many pharmacological c.n.s . tests , show interesting neuroleptic activity but inferior to those of haloperidol and chlorpromazine . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
107,
118
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
153,
164
]
} |
my last three trials were a trial of photocoagulation in diabetic retinopathy ( drs ) , a six-country trial of the antiarrhythmic drug mexiletine ( impact ) , and a study involving two diagnostic procedures for pulmonary embolism ( pioped ) . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
115,
129
]
} | {
"id": "C0025887",
"name": "mexiletine",
"pos": [
135,
145
]
} |
thiol s-methylation is an important pathway in the metabolism of many sulfhydryl compounds including the antihypertensive drug captopril and the antirheumatic medication d-penicillamine . | therapeutic_class_of | {
"id": "C0003191",
"name": "antirheumatic",
"pos": [
145,
158
]
} | {
"id": "C0030817",
"name": "penicillamine",
"pos": [
172,
185
]
} |
we studied the antibacterial activity of amoxycillin , clavulanic acid and the combination , against 1210 clinical isolates with plasmid-mediated ampicillin resistance , isolated at the zaragoza clinical university hospital during 12 years . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
15,
28
]
} | {
"id": "C0002645",
"name": "amoxycillin",
"pos": [
41,
52
]
} |
we studied the antibacterial activity of amoxycillin , clavulanic acid and the combination , against 1210 clinical isolates with plasmid-mediated ampicillin resistance , isolated at the zaragoza clinical university hospital during 12 years . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
15,
28
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
146,
156
]
} |
all isolates were sensitive to most of the commonly used antimicrobials , except tetracycline and streptomycin . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobials",
"pos": [
57,
71
]
} | {
"id": "C0039644",
"name": "tetracycline",
"pos": [
81,
93
]
} |
among the oral antibacterial and antibiotic agents and penicillins examined , piperacillin ( pipc ) was the most active against proteus mirabilis . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
15,
28
]
} | {
"id": "C0031955",
"name": "piperacillin",
"pos": [
78,
90
]
} |
this effect may explain the clinically favorable antiarrhythmic efficacy of mexiletine and quinidine combination therapy . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
49,
63
]
} | {
"id": "C0025887",
"name": "mexiletine",
"pos": [
76,
86
]
} |
this effect may explain the clinically favorable antiarrhythmic efficacy of mexiletine and quinidine combination therapy . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
49,
63
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
91,
100
]
} |
inhibition of thyroid hormone effect in the heart may contribute to the antiarrhythmic properties of amiodarone ; | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
72,
86
]
} | {
"id": "C0002598",
"name": "amiodarone",
"pos": [
101,
111
]
} |
antagonism of serum of mice infected with chloroquine-resistant 'ns ' line to the antimalarial action of chloroquine . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial",
"pos": [
82,
94
]
} | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
105,
116
]
} |
there were significant differences with respect to parasitemia between the smns + cq group and the smcs + cq or sm + cq group ( p less than 0.05 ) , suggesting that smns may be antagonistic to the antimalarial action of chloroquine . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial",
"pos": [
197,
209
]
} | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
220,
231
]
} |
antifungal agents associations are widely used in therapy of deep mycotic diseases , particularly amphotericin b-5-fluorocytosine association . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal agents",
"pos": [
0,
17
]
} | {
"id": "C0002679",
"name": "amphotericin b",
"pos": [
98,
112
]
} |
antiparasitic efficacy of ivermectin against migrating gasterophilus intestinalis was evaluated in 36 treated and 24 nontreated ( n = 12 ) or vehicle-treated ( n = 12 ) ponies experimentally and naturally infected with g intestinalis and naturally infected with g nasalis . | therapeutic_class_of | {
"id": "C0003404",
"name": "antiparasitic",
"pos": [
0,
13
]
} | {
"id": "C0022322",
"name": "ivermectin",
"pos": [
26,
36
]
} |
[ kinetics of the antibacterial effect of ampicillin and sulbactam combinations in dynamic and static conditions ] . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
18,
31
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
42,
52
]
} |
it seems probable that repeated neuroleptic ( haloperidol and raclopride ) treatment causes the hyposensitivity of sigma and phencyclidine receptors , despite the increase of their number . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
32,
43
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
46,
57
]
} |
transplacental transfer of the anti-epileptic agent phenytoin ( pht ) , its phase i metabolite , p-hydroxy-phenytoin ( p-oh-pht ) , and its phase ii conjugate p-oh-pht-glucuronide , was studied in term placental lobules perfused single pass in both maternal and fetal circuits . | therapeutic_class_of | {
"id": "C0003299",
"name": "anti-epileptic agent",
"pos": [
31,
51
]
} | {
"id": "C0031507",
"name": "pht",
"pos": [
164,
167
]
} |
the influence of antiarrhythmic drugs ( oral lidocaine , palpitine , etacizine ) on blood platelet aggregation and prostaglandin metabolites was studied in 91 patients with ischaemic heart disease . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drugs",
"pos": [
17,
37
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
45,
54
]
} |
in a different series of experiments , the antiarrhythmic action of the racemic form was compared to that of ( + ) -sotalol using wistar rats . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
43,
57
]
} | {
"id": "C0037707",
"name": "sotalol",
"pos": [
116,
123
]
} |
it is concluded that the antiarrhythmic effect of sotalol against reperfusion-induced arrhythmias may not be related to beta-adrenergic blockade but probably to class iii type activity . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
25,
39
]
} | {
"id": "C0037707",
"name": "sotalol",
"pos": [
50,
57
]
} |
despite differences in the profile of reperfusion-induced arrhythmias between sprague-dawley and wistar rats , both strains were sensitive to the antiarrhythmic action of ( +/- ) -sotalol . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
146,
160
]
} | {
"id": "C0037707",
"name": "sotalol",
"pos": [
180,
187
]
} |
because of its broad spectrum antibacterial activity cefotaxime is active against most of the causative organisms , including multiresistant strains ( except enterococci ) . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
30,
43
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
53,
63
]
} |
electrophysiological effects , antiarrhythmic activity and kinetics of levorotatory disopyramide ( r ( - ) dp ) and racemic disopyramide ( equimolar mixture of r ( - ) dp and s ( + ) dp ) were compared in patients with ventricular arrhythmias . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
31,
45
]
} | {
"id": "C0012702",
"name": "disopyramide",
"pos": [
124,
136
]
} |
an attempt has been made to study the dynamics in the epidemiology of a locality where the local strains of plasmodium falciparum have developed resistance to the antimalarial chloroquine . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial",
"pos": [
163,
175
]
} | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
176,
187
]
} |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.