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the release of gh from chicken pituitary glands incubated with intact hypothalami was increased in the presence of anti-srif-28 ( 1-14 ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalami",
"pos": [
70,
81
]
} | {
"id": "C0037659",
"name": "srif",
"pos": [
120,
124
]
} |
pro-rbcs , in contrast to mature rbcs , contain abundant heterochromatin , mitochondria , and polyribosomes , and synthesize hemoglobin . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "rbcs",
"pos": [
4,
8
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
125,
135
]
} |
we have recently cloned an islet cell line from a rat pancreatic islet cell tumour that simultaneously expresses the glucagon , insulin , somatostatin , and angiotensinogen genes . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "islet",
"pos": [
27,
32
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
128,
135
]
} |
although the specificity and restriction patterns of t lymphocytes are determined by the t cell receptor for antigen , cd4 might represent an additional `` '' interaction '' '' molecule that is required to strengthen the interaction between t cells , antigen , and antigen-presenting cells . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t lymphocytes",
"pos": [
53,
66
]
} | {
"id": "C0034790",
"name": "t cell receptor",
"pos": [
89,
104
]
} |
differences were most marked at 4 degrees c for 60 min with phagocytosis of opsonized kif aggregates by 23 +/- 8 % of monocytes in contrast to phagocytosis by only 0.2 +/- 3 % monocytes when nonopsonized kif aggregates were used . | tissue_is_expression_site_of_gene_product | {
"id": "C0026473",
"name": "monocytes",
"pos": [
118,
127
]
} | {
"id": "C0108768",
"name": "2",
"pos": [
166,
167
]
} |
immunofluorescent staining with either rabbit polyclonal or mouse monoclonal antibodies to human platelet tsp yielded specific granular staining within the cytoplasm of keratinocytes . | tissue_is_expression_site_of_gene_product | {
"id": "C0005821",
"name": "platelet",
"pos": [
97,
105
]
} | {
"id": "C0076560",
"name": "tsp",
"pos": [
106,
109
]
} |
trichloroacetic acid precipitation , sodium dodecyl sulfate-polyacrylamide gel electrophoresis ( sds-page ) , and autoradiography revealed a major labeled band comigrating with purified platelet tsp in both the media and the cellular lysates . | tissue_is_expression_site_of_gene_product | {
"id": "C0005821",
"name": "platelet",
"pos": [
186,
194
]
} | {
"id": "C0076560",
"name": "tsp",
"pos": [
195,
198
]
} |
the activity of adenohypophyseal beta-endorphin- ( beta-ep ) secreting corticotrophs , in contrast to prolactin- ( prl ) secreting lactotrophs , was increased in arthritic rats . | tissue_is_expression_site_of_gene_product | {
"id": "C0032008",
"name": "adenohypophyseal",
"pos": [
16,
32
]
} | {
"id": "C0033371",
"name": "prolactin",
"pos": [
102,
111
]
} |
effects of acetylcholine ( ach ) and gamma-aminobutyric acid ( gaba ) on immunoreactive corticotropin-releasing factor ( crf ) release from the rat hypothalamus were examined using a rat hypothalamic perifusion system and a rat crf ria in vitro . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
187,
199
]
} | {
"id": "C0010132",
"name": "crf",
"pos": [
228,
231
]
} |
on immunostaining of this bm with monoclonal antibody c ( iv ) 22 , type iv collagen stained heavily , mainly in the disrupted lamina densa ; | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "bm",
"pos": [
26,
28
]
} | {
"id": "C0009333",
"name": "type iv collagen",
"pos": [
68,
84
]
} |
since macrophages and macrophage-derived factors have been found to promote synthesis of bm collagen type iv , and since transitional and interstitial areas are rich in macrophages and histiocytes , respectively , it is suggested that these mononuclear cells and the factors secreted by them play a significant role in the thickening of the bm of pcv and capillaries in ra synovitis . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "bm",
"pos": [
89,
91
]
} | {
"id": "C0009333",
"name": "collagen type iv",
"pos": [
92,
108
]
} |
the presence of sm-c/igf-i in the islets of langerhans may contribute to the growth and development of the insulin-producing beta-cell . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "islets of langerhans",
"pos": [
34,
54
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
107,
114
]
} |
in the reactivity assays clones were tested for responses to autologous and allogeneic pmc , thyroid cells , human thyroglobulin ( htg ) , and microsomal antigen . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
93,
100
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
115,
128
]
} |
in the thyroid antigen proliferation assays 11 % of thyroiditis clones reacted to human thyroglobulin , but none responded to microsomal antigen . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
7,
14
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
88,
101
]
} |
this polarization is independent of a basement membrane , since it is maintained when mcf-7 cells , which do not deposit type iv collagen themselves , are grown directly on plastic . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membrane",
"pos": [
38,
55
]
} | {
"id": "C0009333",
"name": "type iv collagen",
"pos": [
121,
137
]
} |
taken together , these data lend support to a model of primate sexual maturation in which the primary regulator of gonadotropin secretion in both sexes during the prolonged juvenile phase is central inhibition of the hypothalamic gnrh regulator . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
217,
229
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
230,
234
]
} |
the hyaline bodies found in the first six diseases displayed intense immunoreactivity for the basement membrane components , type iv collagen , and laminin , whereas the hyaline bodies occurring in the latter three diseases were unreactive . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membrane",
"pos": [
94,
111
]
} | {
"id": "C0009333",
"name": "type iv collagen",
"pos": [
125,
141
]
} |
the tumor did not involve the prostate gland , and immunohistochemical stains for prostate-specific antigen and prostatic acid phosphatase were negative . | tissue_is_expression_site_of_gene_product | {
"id": "C0033572",
"name": "prostate gland",
"pos": [
30,
44
]
} | {
"id": "C0138741",
"name": "prostate-specific antigen",
"pos": [
82,
107
]
} |
seemingly , excessive methionine intake leads to production of an intermediate of the methionine catabolism that may affect rbc directly as an intensive oxidizing agent , resulting in an excessive oxidation of hemoglobin to methb and heinz-body formation . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "rbc",
"pos": [
124,
127
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
210,
220
]
} |
seemingly , excessive methionine intake leads to production of an intermediate of the methionine catabolism that may affect rbc directly as an intensive oxidizing agent , resulting in an excessive oxidation of hemoglobin to methb and heinz-body formation . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "rbc",
"pos": [
124,
127
]
} | {
"id": "C0025635",
"name": "methb",
"pos": [
224,
229
]
} |
moreover , in this population , red cell dpg content was directly related to hexokinase and glucose 6-phosphate dehydrogenase activities while haemoglobin-oxygen affinity ( p50 ) was inversely related to all five enzyme activities . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cell",
"pos": [
32,
40
]
} | {
"id": "C0019046",
"name": "haemoglobin",
"pos": [
143,
154
]
} |
moreover , relationships of red cell enzymes to one another , to serum phosphate levels and to both red cell dpg content and haemoglobin-oxygen affinity were significantly different in androgen-treated subjects than in the untreated haemodialysis group . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cell",
"pos": [
28,
36
]
} | {
"id": "C0019046",
"name": "haemoglobin",
"pos": [
125,
136
]
} |
initial red cell glycogen values in 24 healthy volunteers ranged from 11-60 micrograms/g haemoglobin which compares with 20-105 micrograms/g haemoglobin previously reported . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cell",
"pos": [
8,
16
]
} | {
"id": "C0019046",
"name": "haemoglobin",
"pos": [
141,
152
]
} |
the results of this study indicate that a significant , although somewhat modest , amount of variance on brainstem auditory , pattern visual and somatosensory erp latency can be predicted by routinely obtained liver functional measures , albumin , prothrombin time , fasting ammonia level , globulin and especially indocyanine green clearance . | tissue_is_expression_site_of_gene_product | {
"id": "C0023884",
"name": "liver",
"pos": [
210,
215
]
} | {
"id": "C0017649",
"name": "globulin",
"pos": [
291,
299
]
} |
a possible role of the thymus is suggested by the ability of thymosin to suppress anti-dna . | tissue_is_expression_site_of_gene_product | {
"id": "C0040113",
"name": "thymus",
"pos": [
23,
29
]
} | {
"id": "C0040106",
"name": "thymosin",
"pos": [
61,
69
]
} |
the stretch-induced changes in muscle wet weight could , in part , be attributed to changes in muscle protein . | tissue_is_expression_site_of_gene_product | {
"id": "C0026845",
"name": "muscle",
"pos": [
31,
37
]
} | {
"id": "C0026832",
"name": "muscle protein",
"pos": [
95,
109
]
} |
the red cells of the arcid clam anadara ovalis contain two electrophoretically distinct hemoglobins : hb major ( hb ma ) and hb minor ( hb mi ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cells",
"pos": [
4,
13
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
136,
138
]
} |
its mrna is detectable in the prostate but not in the testis , which suggests that it is primarily a prostatic secretory protein . | tissue_is_expression_site_of_gene_product | {
"id": "C0033572",
"name": "prostate",
"pos": [
30,
38
]
} | {
"id": "C0525289",
"name": "prostatic secretory protein",
"pos": [
101,
128
]
} |
these results demonstrate that : sct inhibits pulsatile gh secretion via a central nervous system site of action , gh suppression induced by sct is apparently not due solely to increased hypothalamic srif release , and centrally administered sct produces an acute loss of responsiveness of somatotrophs to grf , which can be dissociated from peripheral blood calcium levels . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
187,
199
]
} | {
"id": "C0037659",
"name": "srif",
"pos": [
200,
204
]
} |
these results demonstrate that : sct inhibits pulsatile gh secretion via a central nervous system site of action , gh suppression induced by sct is apparently not due solely to increased hypothalamic srif release , and centrally administered sct produces an acute loss of responsiveness of somatotrophs to grf , which can be dissociated from peripheral blood calcium levels . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
187,
199
]
} | {
"id": "C0023610",
"name": "grf",
"pos": [
306,
309
]
} |
in particular , activation of alpha 2-adrenoceptors stimulates gh secretion via endogenous ghrh release , although a mechanism operating to inhibit hypothalamic ss release can not be excluded ; | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
148,
160
]
} | {
"id": "C0037659",
"name": "ss",
"pos": [
161,
163
]
} |
stimulation of alpha 1-adrenoceptors is inhibitory to gh secretion exclusively via an increased release of hypothalamic ss . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
107,
119
]
} | {
"id": "C0037659",
"name": "ss",
"pos": [
120,
122
]
} |
the gonadal and accessory organ atrophy following transfer of male hamsters from long ( lp ) to short photoperiod ( sp ) is preceded by reduced prolactin secretion and involves reductions in hypothalamic lhrh release and catecholamine turnover . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
191,
203
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
204,
208
]
} |
two analogs of the hypothalamic luteinizing hormone releasing factor modified at the histidine-2 position were tested for biological activity ( secretion of luteinizing hormone ) in cultures of dispersed rat anterior pituitary cells . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
19,
31
]
} | {
"id": "C0023610",
"name": "luteinizing hormone releasing factor",
"pos": [
32,
68
]
} |
plasma hemopexin levels following aortic valve replacement : a valuable screening test for assessing the severity of cardiac hemolysis . | tissue_is_expression_site_of_gene_product | {
"id": "C0032105",
"name": "plasma",
"pos": [
0,
6
]
} | {
"id": "C0019067",
"name": "hemopexin",
"pos": [
7,
16
]
} |
effect of exposure to simulated high altitude on human red cell phosphates and oxygen affinity of hemoglobin . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cell",
"pos": [
55,
63
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
98,
108
]
} |
concomitant increases in serum growth hormone and hypothalamic somatostatin in rats after injection of gamma-aminobutyric acid , aminooxyacetic acid , or gamma-hydroxybutyric acid . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
50,
62
]
} | {
"id": "C0037659",
"name": "somatostatin",
"pos": [
63,
75
]
} |
aminooxyacetic acid at 20 mg produced a significant increase in both serum gh and hypothalamic srif . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
82,
94
]
} | {
"id": "C0037659",
"name": "srif",
"pos": [
95,
99
]
} |
furthermore , 12.5 mg gamma-hydroxybutyric acid ( ghb ) injected ip into urethane- or pentobarbital-anesthetized rats elicited a significant increase in both serum gh and hypothalamic srif . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
171,
183
]
} | {
"id": "C0037659",
"name": "srif",
"pos": [
184,
188
]
} |
pretreatment with 20 mg l-dopa produced decreases in the ghb-induced serum gh increase and in hypothalamic srif in pentobarbital-anesthetized rats . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
94,
106
]
} | {
"id": "C0037659",
"name": "srif",
"pos": [
107,
111
]
} |
these results show that gaba and ghb stimulated gh secretion , which was accompanied by increased hypothalamic srif . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
98,
110
]
} | {
"id": "C0037659",
"name": "srif",
"pos": [
111,
115
]
} |
thus , the gh release induced by gaba or ghb may be partly involved in inhibiting the release of hypothalamic srif . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
97,
109
]
} | {
"id": "C0037659",
"name": "srif",
"pos": [
110,
114
]
} |
modulation of hypothalamic luteinizing hormone-releasing hormone levels by intracranial and subcutaneous implants of gonadal steroids in castrated rats : effects of androgen and estrogen antagonists . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
14,
26
]
} | {
"id": "C0023610",
"name": "luteinizing hormone-releasing hormone",
"pos": [
27,
64
]
} |
since hyperprolactinemia is associated with increased hypothalamic dopamine turnover ( which may reflect increased dopaminergic activity ) , inhibition of gnrh by dopamine in this situation would be maximal . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
54,
66
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
155,
159
]
} |
the rate of methemoglobin reduction in red cells from an individual who is heterozygous for both nadh-methoglobin reductase deficiency and hb wood shows the combined effects of the two mutations . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cells",
"pos": [
39,
48
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
139,
141
]
} |
in isolated rat pancreatic islets maintained for 2 d in tissue culture , the effects of ibmx on insulin release and 45ca++ fluxes were compared with those of glucose . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "pancreatic islets",
"pos": [
16,
33
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
96,
103
]
} |
removal of t cells bearing ia determinants or t cells with fc-igg receptors did not diminish the suppressive effect of at cells on normal b-cell ig synthesis . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
11,
18
]
} | {
"id": "C0034790",
"name": "t cells",
"pos": [
120,
127
]
} |
this report describes studies with nerve endings isolated from the rat hypothalamus in which dopamine at higher concentrations than those used previously has been found to stimulate the degradation of lh-rh but not thyrotropin releasing hormone ( trh ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
71,
83
]
} | {
"id": "C0023610",
"name": "lh-rh",
"pos": [
201,
206
]
} |
the concentration of hypothalamic immunoreactive lhrh was more than 5-fold greater than that of the extrahypothalamic brain . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
21,
33
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
49,
53
]
} |
mammalian and amphibian hypothalamic immunoreactive lhrh yielded displacement curves parallel to those of synthetic lhrh in assays employing four antisera which recognize different regions of the decapeptide , thus suggesting a similarity in the structure of their lhrh . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
24,
36
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
265,
269
]
} |
hypothalamic immunoreactive lhrh from the bird , reptile , teleost , and elasmobranch differed from the mammalian and amphibian peptide in yielding displacement curves nonparallel to those of synthetic lhrh with three different antisera ( 1076 , 743 , and 744 ) which bind between trp3 and pro9 of lhrh . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
0,
12
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
298,
302
]
} |
with antiserum 422 which binds the nh2- and co2h- termini of lhrh , bird , reptile , and teleost hypothalamic extracts yielded displacement curves parallel to that of synthetic lhrh . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
97,
109
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
177,
181
]
} |
by contrast , assay of bird , reptile , teleost , and elasmobranch hypothalamic extracts with antiserum 422 gave much higher values than did the other antisera , suggesting that the lhrh peptide is structurally different from mammalian and amphibian lhrh in the region of leu7 but similar at the nh2- and co2h-termini . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
67,
79
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
250,
254
]
} |
structural differences in vertebrate hypothalamic immunoreactive lhrh were confirmed by cation exchange and high pressure liquid chromatography . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
37,
49
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
65,
69
]
} |
it is postulated that the intracellular concentration of k+ in islet cells participates in the long term regulation of insulin release by glucose . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "islet cells",
"pos": [
63,
74
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
119,
126
]
} |
a rabbit antiserum to synthetic lhrh was shown to be specific to rat hypothalamic lhrh , as revealed by binding studies ( ria ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
69,
81
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
82,
86
]
} |
although estrogen and progesterone may induce a change in pituitary responsiveness to hypothalamic lhrh in ovariectomized rats , the present study provides evidence that tonic and/or increased lhrh release is required for the acute increase in lh release caused by progesterone . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
86,
98
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
193,
197
]
} |
peripheral blood from children with bronchial asthma was examined for the proportions of t cells , t cells with receptors for igm ( t mu ) or igg ( t gamma ) , and locomotion of t cells in the presence of chemoattractants casein and endotoxin-activated serum ( eas ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
89,
96
]
} | {
"id": "C0034790",
"name": "t cells",
"pos": [
178,
185
]
} |
the presence of a transplanted prolactin- and gh-secreting pituitary tumor ( furth mtt.215 ) in inbred male rats resulted in increased hypothalamic lhrh and pituitary lh content , decreased serum lh and testosterone concentrations , and very high serum prolactin values . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
135,
147
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
148,
152
]
} |
these results that inhibitory effects of the transplanted pituitary tumor on lh and testosterone secretion were affected both a reduction in hypothalamic lhrh release and a reduced responsiveness of the pituitary to lhrh . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
141,
153
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
216,
220
]
} |
interaction of the anti-estrogen ci-628 and estradiol on plasma lh and hypothalamic lh-rh in the female rat . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
71,
83
]
} | {
"id": "C0023610",
"name": "lh-rh",
"pos": [
84,
89
]
} |
ci-628 acts at the pituitary level to decrease the tissue sensitivity to lh-rh , but has no effect on mediobasal hypothalamic ( mbh ) lh-rh content . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
113,
125
]
} | {
"id": "C0023610",
"name": "lh-rh",
"pos": [
134,
139
]
} |
erythrocyte superoxide dismutase activity in three cases of typical fanconi 's anaemia was markedly depressed , when expressed either per mg of haemoglobin or per number of cells , and its aetiological significance is discussed . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
0,
11
]
} | {
"id": "C0019046",
"name": "haemoglobin",
"pos": [
144,
155
]
} |
these data further support the concept of a link ( as yet undefined ) between the hypothalamus and the endocrine pancreas , as lesions of the vmh area resulted in abnormal secretion not only of insulin , but of glucagon as well . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "endocrine",
"pos": [
103,
112
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
194,
201
]
} |
the hypothalamic tetradecapeptide , somatostatin ( srif ) , inhibits the secretion of growth hormone ( gh ) and numerous other hormones , including insulin and glucagon . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
4,
16
]
} | {
"id": "C0037659",
"name": "srif",
"pos": [
51,
55
]
} |
of 145 patients without residual thyroid tissue and a negative whole body scan , 6 patients exhibited significant tg levels . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
33,
40
]
} | {
"id": "C0040123",
"name": "tg",
"pos": [
114,
116
]
} |
proceedings : inhibition of hypothalamic unit activity by iontophoretically applied luteinizing hormone releasing factor and thyrotrophin releasing factor . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
28,
40
]
} | {
"id": "C0023610",
"name": "luteinizing hormone releasing factor",
"pos": [
84,
120
]
} |
effect of androgens on the red cell 2 , 3 diphosphoglycerate hemoglobin oxygen affinity and red cell mass in mammals . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cell",
"pos": [
27,
35
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
61,
71
]
} |
red cell 2,3-dpg levels were higher in the calf foetus than in the mother , but in the ruminant 2,3-dpg has no effect on the affinity of haemoglobin for o ( 2 ) and the differences in p ( 50 ) between foetus and mother could be ascribed to the presence of a foetal haemoglobin.4 . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cell",
"pos": [
0,
8
]
} | {
"id": "C0019046",
"name": "haemoglobin",
"pos": [
265,
276
]
} |
[ premature activation of the hypothalamic-pituitary system in idiopathic precocious puberty : effect of lh-rh and clomiphene administration on fsh and lh secretion ( author 's transl ) ] . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
30,
42
]
} | {
"id": "C0023610",
"name": "lh-rh",
"pos": [
105,
110
]
} |
we have analyzed oxygen-linked carbamate formation in sheep hemoglobin b by measuring a ) the effect of co2 on oxygen affinity and bohr effect in red cell suspensions and dilute ( 1.3 mm hb4 ) and concentrated ( 5 mm hb4 ) hemoglobin solutions at 37 degrees c and b ) co2 binding curves of deoxygenated and oxygenated whole blood and hemoglobin solutions , respectively , at the same temperature . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cell",
"pos": [
146,
154
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
334,
344
]
} |
one influence , from the hypothalamus is mediated by the hypothalamic hypophysiotrophic hormones , which are elaborated in specialized neurones and reach the pituitary by way of the hypophysial-portal vessels . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
25,
37
]
} | {
"id": "C0020656",
"name": "hypothalamic",
"pos": [
57,
69
]
} |
we have induced primary liver tumors in macaques with several nitrosamines and aflatoxin b1 and these tumors produce alpha-fetoprotein ( afp ) which can be assayed for both diagnosis and therapy . | tissue_is_expression_site_of_gene_product | {
"id": "C0023884",
"name": "liver",
"pos": [
24,
29
]
} | {
"id": "C0002210",
"name": "alpha-fetoprotein",
"pos": [
117,
134
]
} |
the variant was readily identified by electrophoresis and chromatography , and comprised about 30 % of the red cell hemoglobin . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cell",
"pos": [
107,
115
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
116,
126
]
} |
these results establish that , in the hypothalamus , somatostatin is mainly concentrated in the median eminence and suggest that periventricular organs can play a role in the regulation of growth hormone secretion . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
38,
50
]
} | {
"id": "C0037659",
"name": "somatostatin",
"pos": [
53,
65
]
} |
in striking contrast , in the mid-hypothalamic region , gn-rh content increased gradually , rising dramatically just prior to vaginal opening . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
34,
46
]
} | {
"id": "C0023610",
"name": "gn-rh",
"pos": [
56,
61
]
} |
the developmental pattern of gn-rh content is consistent with the maturation of those hypothalamic structures concerned with synthesis , transport and storage of gn-rh . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic structures",
"pos": [
86,
109
]
} | {
"id": "C0023610",
"name": "gn-rh",
"pos": [
162,
167
]
} |
hypothalamic extract and some of the lh-rh analogues produced displacement curves which were parallel to that obtained with the synthetic lh-rh . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
0,
12
]
} | {
"id": "C0023610",
"name": "lh-rh",
"pos": [
138,
143
]
} |
the maximal erythrocytic content of hemoglobin in the 40-mo-old animals was significantly lower than that of all other age groups . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocytic",
"pos": [
12,
24
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
36,
46
]
} |
circulating t cells ( t.tdl ) failed to display fcr : a ) despite the use of a wide range of the above labeling techniques , each of which was shown to detect fcr on other t cells , thymoma cells , and b cells , and b ) even after removal of ig associated with their cell membranes . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
12,
19
]
} | {
"id": "C0034790",
"name": "fcr",
"pos": [
159,
162
]
} |
in contrast to b cell fcr which bound igg1 preferentially , those on t cells bound both igg1 and igg2 , raising the possibility that the fcr on t cell is distinct from that on b cell . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
69,
76
]
} | {
"id": "C0034790",
"name": "fcr",
"pos": [
137,
140
]
} |
the major thyroid protein was normal thyroglobulin which could be readily iodinated in the presence of h2o2 and horse radish peroxidase . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
10,
17
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
37,
50
]
} |
intravenous injection of 20 mug of l-thyroxine ( t4 ) induced repletion of tsh to supranormal levels in the adenohypophysis of goitrous rats without a significant change in prl stores . | tissue_is_expression_site_of_gene_product | {
"id": "C0032008",
"name": "adenohypophysis",
"pos": [
108,
123
]
} | {
"id": "C0033371",
"name": "prl",
"pos": [
173,
176
]
} |
our evidence indicates that different red blood cell lines are produced by the two tissues and that these different cell lines contain different tadpole hemoglobins . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red blood cell",
"pos": [
38,
52
]
} | {
"id": "C0019046",
"name": "hemoglobins",
"pos": [
153,
164
]
} |
although it is easily measurable in hypothalamic extracts , we have failed to detect gnrh in plasma and urine from normal subjects and menopausal women . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
36,
48
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
85,
89
]
} |
purification and characterisation of two porcine hypothalamic fractions with lh-releasing activity : evidence for a single lh and fsh-releasing hormone . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
49,
61
]
} | {
"id": "C0023610",
"name": "fsh-releasing hormone",
"pos": [
130,
151
]
} |
this effect was not related to changes in the level of antigen trapping by lymph node macrophages , but the lymphocyte mitogenic activity may have been important for the response since there was a significant increase in [ 3h ] thymidine incorporation within the lymphokine-treated nodes on the 3rd day following immunization . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocyte",
"pos": [
108,
118
]
} | {
"id": "C0024297",
"name": "lymphokine",
"pos": [
263,
273
]
} |
the metabolic integrity of the muscle tissue was proved by measuring creatine phosphate , atp , adp and water content as well as by the significant insulin effect on glucose uptake and on [ 14c ] leucine incorporation into muscle proteins . | tissue_is_expression_site_of_gene_product | {
"id": "C0026845",
"name": "muscle",
"pos": [
31,
37
]
} | {
"id": "C0026832",
"name": "muscle proteins",
"pos": [
223,
238
]
} |
hypothalamic , pituitary , and gonadal reserve and responsiveness were evaluated by clomiphene , lhrh , and hcg tests . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
0,
12
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
97,
101
]
} |
comparative chromatographic and immunological characterization of this peptide along with synthetic ( hypothalamic-like ) somatostatin-14 and -28 , indicates that both molecular forms are present in the plant . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
102,
114
]
} | {
"id": "C0037659",
"name": "somatostatin-14",
"pos": [
122,
137
]
} |
the alpha 1-adrenergic receptors on frtl-5 thyroid cells have been functionally linked to iodide efflux into the follicular lumen and to the iodination of thyroglobulin -- i.e. , to the formation of thyroid hormones ; | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
43,
50
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
155,
168
]
} |
in diagnostic histopathology , immunocytochemical staining of basement membrane components such as type iv collagen and laminin may help to distinguish between noninvasive ( benign or in situ ) and invasive lesions . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membrane",
"pos": [
62,
79
]
} | {
"id": "C0009333",
"name": "type iv collagen",
"pos": [
99,
115
]
} |
finally , the use of a reconstituted basement membrane containing known amounts of laminin , type iv collagen , and heparan sulfate proteoglycan as a standard , led to the conclusion that , in the tumor matrix , the relative content of laminin to type iv collagen to the proteoglycan was in a ratio of 1:0.6:0.03 , suggesting molar ratios of approximately 1:1:0.2 , respectively . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membrane",
"pos": [
37,
54
]
} | {
"id": "C0009333",
"name": "type iv collagen",
"pos": [
247,
263
]
} |
recent studies using cloned antigen specific t lymphocytes and monoclonal antibodies directed at their various surface glycoprotein components have led to identification of the human t cell antigen receptor as a surface complex comprised of a clonotypic 90 kd ti heterodimer and the in-variant 20 and 25 kd t3 molecules . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t lymphocytes",
"pos": [
45,
58
]
} | {
"id": "C0034790",
"name": "t cell antigen receptor",
"pos": [
183,
206
]
} |
cultured microvascular endothelial cells isolated from human dermis were examined for the synthesis of basement membrane specific ( type iv ) collagen and its deposition in subendothelial matrix . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membrane",
"pos": [
103,
120
]
} | {
"id": "C0009333",
"name": "type iv",
"pos": [
132,
139
]
} |
in preliminary studies four out of 113 human mcab against thyroid or orbital tissue antigens showed reactivity restricted to tg and octmem . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
58,
65
]
} | {
"id": "C0040123",
"name": "tg",
"pos": [
125,
127
]
} |
the determinations made prior to and after training included the peripheral blood erythrocyte ( er ) and reticulocyte ( ret . ) count , the hemoglobin concentration ( hb ) and packed cell volume ( pcv ) and , determined by spectrophotometric methods , the activity of pyruvate kinase ( pk ) , glucose-6-phosphate dehydrogenase ( g6pd ) and glutathione reductase ( gr ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "peripheral blood erythrocyte",
"pos": [
65,
93
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
167,
169
]
} |
all the experimental groups revealed a drop in erythrocyte count ( er ) , hemoglobin concentration ( hb ) , and hematocrit values ( pcv ) , as well as an increase in the reticulocytes count ( ret ) and in the activity of all the enzymes investigated . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "er",
"pos": [
11,
13
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
101,
103
]
} |
in the fourth group anemia was detected : prolonged endurance training decreased the rbc by 24.2 % , hb by 31.1 % , pcv by 26.2 % and increased the reticulocyte count by 881.6 % . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "rbc",
"pos": [
85,
88
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
101,
103
]
} |
in the control culture of early placenta , hcg , hcg alpha and hpl in the medium showed marked increases compared to the initial tissue levels , whereas hcg , hcg alpha and immunoreactive hcg beta in the tissue explants remained constant . | tissue_is_expression_site_of_gene_product | {
"id": "C0032043",
"name": "placenta",
"pos": [
32,
40
]
} | {
"id": "C0106132",
"name": "hcg beta",
"pos": [
188,
196
]
} |
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