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plasma protein content ( an index of liver protein synthesis ) was generally in the normal range , whereas anthropometry and the biochemical muscle indices were generally subnormal , suggesting a depressed muscle protein content and synthesis ( evaluated , respectively , by the asp : dna and rna : dna ratios ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0026845",
"name": "muscle",
"pos": [
141,
147
]
} | {
"id": "C0026832",
"name": "muscle protein",
"pos": [
206,
220
]
} |
cd4+-leu-7+ cell-derived clones retained their cd3 and cd4 surface antigens , lost the leu-7 marker , and acquired hla-dr determinants . | tissue_is_expression_site_of_gene_product | {
"id": "C0039215",
"name": "cd4",
"pos": [
0,
3
]
} | {
"id": "C0019764",
"name": "hla-dr",
"pos": [
115,
121
]
} |
following behavioural testing the animals were bled by cardiac puncture for measurement of plasma testosterone levels , and their hypothalami removed and assayed for dopamine , noradrenaline , 5-hydroxytryptamine ( 5-ht ) and lh-releasing hormone ( lhrh ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalami",
"pos": [
130,
141
]
} | {
"id": "C0023610",
"name": "lh-releasing hormone",
"pos": [
226,
246
]
} |
neonatal administration of thc altered adult male sexual responses and had no effect on hypothalamic noradrenaline , 5-ht and lhrh concentrations . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
88,
100
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
126,
130
]
} |
gel filtration ( sephadex g-150 ) of erythrocyte lysates revealed that se was deposited mainly in two proteins , glutathione peroxidase ( gpx ) and hemoglobin ( hb ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
37,
48
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
148,
158
]
} |
when selenite or selenocystine was the dietary form of se , the majority of the erythrocyte se was present with gpx , but when the se was supplied from either se-met , yeast or wheat , it was deposited to a greater extent in hb than gpx . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
80,
91
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
225,
227
]
} |
gel-filtration chromatography ( sephadex g-150 ) of erythrocyte lysate revealed labeling of four fractions corresponding to void volume proteins , glutathione peroxidase ( gpx ) , hemoglobin ( hb ) and low-molecular-weight materials . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
52,
63
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
180,
190
]
} |
removal of endogenous oestrogens had no significant effects on plasma fsh , lh or prolactin concentrations or on testicular growth and hypothalamic content of gnrh . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
135,
147
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
159,
163
]
} |
these results suggest that endogenous oestrogens may indirectly suppress testicular androgen secretion by exerting a stimulatory influence on hypothalamic dopaminergic neurones , which in turn may inhibit gnrh secretion by the median eminence . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
142,
154
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
205,
209
]
} |
peripheral blood lymphocytes ( pbls ) and tumor-associated lymphocytes ( tals ) were isolated from 36 patients with advanced ovarian adenocarcinoma and peritoneal effusions for study of lymphokine-activated killer activity . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocytes",
"pos": [
17,
28
]
} | {
"id": "C0024297",
"name": "lymphokine",
"pos": [
186,
196
]
} |
red cells flowing in single-file suspension through capillaries are modelled as evenly spaced , hemoglobin ( hb ) -containing circular particles in a rectangular channel ( two-dimensional case ) or axisymmetric spheres in a circular tube ( three-dimensional case ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cells",
"pos": [
0,
9
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
96,
106
]
} |
in spite of many experimental studies which employ fluorescent ca2+ indicator dye to demonstrate an early increase of [ ca2+ ] i in t-lymphocytes after stimulation with lectins , specific antigens , and monoclonal antibodies to t-lymphocyte receptors , the mechanism responsible for the rise of [ ca2+ ] i is unknown . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t-lymphocytes",
"pos": [
132,
145
]
} | {
"id": "C0034790",
"name": "t-lymphocyte receptors",
"pos": [
228,
250
]
} |
the lymphocyte response to pha in vitro was diminished but pha-induced lymphokine production was not altered . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocyte",
"pos": [
4,
14
]
} | {
"id": "C0024297",
"name": "lymphokine",
"pos": [
71,
81
]
} |
these results support the view that opioids modulate pulsatile gonadotropin release by an action on the hypothalamic lhrh pulse generator . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
104,
116
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
117,
121
]
} |
effects of human pancreatic growth hormone-releasing hormone and fragments of rat hypothalamic growth hormone-releasing hormone on the activity of rat brain neurons . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
82,
94
]
} | {
"id": "C0037668",
"name": "growth hormone-releasing hormone",
"pos": [
95,
127
]
} |
we also show that basic fgf concomitantly stimulates endothelial cells to produce a urokinase-type plasminogen activator , a protease that has been implicated in the neovascular response . | tissue_is_expression_site_of_gene_product | {
"id": "C0225336",
"name": "endothelial cells",
"pos": [
53,
70
]
} | {
"id": "C0042071",
"name": "urokinase-type",
"pos": [
84,
98
]
} |
after 60 min preincubation the released ghrf from sliced rat hypothalamic fragments during 60 min incubation was detected by a highly specific and sensitive radioimmunoassay for rat ghrf . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
61,
73
]
} | {
"id": "C0037668",
"name": "ghrf",
"pos": [
182,
186
]
} |
these results suggest that this in vitro system is useful for the investigation of the mechanism of ghrf release from the hypothalamus and that igf-1 is probably involved in the feedback inhibition of growth hormone secretion by attenuating ghrf release from the hypothalamus besides countering the effect of ghrf on the pituitary . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
122,
134
]
} | {
"id": "C0037668",
"name": "ghrf",
"pos": [
309,
313
]
} |
after aflatoxin b1 induction of liver carcinogenesis in adult female sprague dawley rats , livers were examined by histology , fluorescence microscopy of the carcinogen and its metabolites , and alphafetoprotein ( afp ) assays . | tissue_is_expression_site_of_gene_product | {
"id": "C0023884",
"name": "livers",
"pos": [
91,
97
]
} | {
"id": "C0002210",
"name": "alphafetoprotein",
"pos": [
195,
211
]
} |
the cells exhibited many characteristics of colonic epithelial cells including the presence of mucopolysaccharides and carcinoembryonic antigen . | tissue_is_expression_site_of_gene_product | {
"id": "C0014597",
"name": "epithelial cells",
"pos": [
52,
68
]
} | {
"id": "C0007082",
"name": "carcinoembryonic antigen",
"pos": [
119,
143
]
} |
human pancreatic ( tumor ) growth hormone-releasing factor ( hpgrf ) and rat hypothalamic growth hormone-releasing factor stimulated gh release to similar levels . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
77,
89
]
} | {
"id": "C0037668",
"name": "growth hormone-releasing factor",
"pos": [
90,
121
]
} |
the residence time ( the time a particular red cell or hemoglobin molecule has spent in the capillary ) for 50 % oxygenation of a 4 mm ( heme ) deoxyhemoglobin solution was approximately 0.05 s at 37 degrees c when the gas space surrounding the capillary contained air . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cell",
"pos": [
43,
51
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
149,
159
]
} |
the residence time ( the time a particular red cell or hemoglobin molecule has spent in the capillary ) for 50 % oxygenation of a 4 mm ( heme ) deoxyhemoglobin solution was approximately 0.05 s at 37 degrees c when the gas space surrounding the capillary contained air . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cell",
"pos": [
43,
51
]
} | {
"id": "C0057437",
"name": "solution",
"pos": [
160,
168
]
} |
in frtl-5 thyroid cells depleted of thyrotropin , insulin , and serum for 3 days , growth and synthesis of thyroglobulin are inhibited . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
10,
17
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
107,
120
]
} |
we have identified and isolated an 88-kd membrane glycoprotein present in platelets , endothelial cells , monocytes , and a variety of human tumor cell lines that is the membrane binding site for tsp . | tissue_is_expression_site_of_gene_product | {
"id": "C0005821",
"name": "platelets",
"pos": [
74,
83
]
} | {
"id": "C0076560",
"name": "tsp",
"pos": [
196,
199
]
} |
we have identified and isolated an 88-kd membrane glycoprotein present in platelets , endothelial cells , monocytes , and a variety of human tumor cell lines that is the membrane binding site for tsp . | tissue_is_expression_site_of_gene_product | {
"id": "C0225336",
"name": "endothelial cells",
"pos": [
86,
103
]
} | {
"id": "C0076560",
"name": "tsp",
"pos": [
196,
199
]
} |
as we have shown that acidosis by itself stimulates muscle protein degradation by a glucocorticoid-dependent mechanism , we assessed the contribution of acidosis to changes in muscle protein turnover in crf . | tissue_is_expression_site_of_gene_product | {
"id": "C0026845",
"name": "muscle",
"pos": [
52,
58
]
} | {
"id": "C0026832",
"name": "muscle protein",
"pos": [
176,
190
]
} |
these j11d- cells behave like peripheral lyt-2+ t cells in two functional assays : they form clonal growth bursts in response to immobilized antibody against the t cell antigen receptor , and they act as precursors of alloreactive cytotoxic t cells . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
48,
55
]
} | {
"id": "C0034790",
"name": "t cell antigen receptor",
"pos": [
162,
185
]
} |
macrophages activated by either ifn-gamma or ifn-beta had an imbalanced accumulation of 28s ribosomal rna compared with their accumulation of 18s ribosomal rna . | tissue_is_expression_site_of_gene_product | {
"id": "C0024432",
"name": "macrophages",
"pos": [
0,
11
]
} | {
"id": "C0015980",
"name": "ifn-beta",
"pos": [
45,
53
]
} |
moreover , they indicate that inhibition of 28s ribosomal rna accumulation in macrophages is a molecular event triggered by ifn-gamma , as well as ifn-beta . | tissue_is_expression_site_of_gene_product | {
"id": "C0024432",
"name": "macrophages",
"pos": [
78,
89
]
} | {
"id": "C0015980",
"name": "ifn-beta",
"pos": [
147,
155
]
} |
previous studies on the mechanism of leukocyte traversal of basement membranes showed that rabbit peritoneal exudate polymorphonuclear cells ( pmn ) preferentially used laminin , a major constituent of basement membrane , to attach to another component , type iv collagen . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membrane",
"pos": [
60,
77
]
} | {
"id": "C0009333",
"name": "type iv collagen",
"pos": [
255,
271
]
} |
macrophages incubated for 24 hr with ifn-beta developed lower levels of cytolytic activity when stimulated with ifn-gamma and lps , in comparison with macrophages pretreated with medium . | tissue_is_expression_site_of_gene_product | {
"id": "C0024432",
"name": "macrophages",
"pos": [
0,
11
]
} | {
"id": "C0015980",
"name": "ifn-beta",
"pos": [
37,
45
]
} |
our results support the concept that beta-adrenergic receptors may modulate either the release or action of hypothalamic somatostatin in the control of gh secretion in man . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
108,
120
]
} | {
"id": "C0037659",
"name": "somatostatin",
"pos": [
121,
133
]
} |
a cytokine network in human diploid fibroblasts : interactions of beta-interferons , tumor necrosis factor , platelet-derived growth factor , and interleukin-1 . | tissue_is_expression_site_of_gene_product | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
36,
47
]
} | {
"id": "C0015980",
"name": "beta-interferons",
"pos": [
66,
82
]
} |
administration of 10 ( -5 ) m 2-methylhistamine , an h1 agonist , induced significant release ( 50-120 % increase , p less than 0.05 ) of lh-rh from the mbh , and addition of 10 ( -5 ) m mepyramine , and h1 antagonist , abolished this lh-rh release . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "mbh",
"pos": [
153,
156
]
} | {
"id": "C0023610",
"name": "lh-rh",
"pos": [
235,
240
]
} |
these findings suggest that histamine induces release of hypothalamic lh-rh , and that histamine h1 receptors in the hypothalamus are involved in the basal and estradiol-induced lh-rh release . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
117,
129
]
} | {
"id": "C0023610",
"name": "lh-rh",
"pos": [
178,
183
]
} |
selection and characterization of t-cell variants lacking molecules involved in t-cell activation ( t3 t-cell receptor , t44 , and t11 ) : analysis of the functional relationship among different pathways of activation . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t-cell",
"pos": [
34,
40
]
} | {
"id": "C0034790",
"name": "t-cell receptor",
"pos": [
103,
118
]
} |
the presence of mal mrna in a panel of t-cell lines that express both the t-cell receptor and the t11 antigen suggests that mal may be involved in membrane signaling in t cells activated via either t11 or t-cell receptor pathways . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
169,
176
]
} | {
"id": "C0034790",
"name": "t-cell receptor",
"pos": [
205,
220
]
} |
moreover , lamellar cells are embedded in an extracellular matrix reminiscent of the basement membrane of epithelium since it contains laminin and collagen iv . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement",
"pos": [
85,
93
]
} | {
"id": "C0009333",
"name": "collagen iv",
"pos": [
147,
158
]
} |
for the anterior pituitary gland , the contents of prolactin , tsh , gh , lh and fsh in male nar were lower than those of normal rats . | tissue_is_expression_site_of_gene_product | {
"id": "C0032008",
"name": "anterior pituitary gland",
"pos": [
8,
32
]
} | {
"id": "C0033371",
"name": "prolactin",
"pos": [
51,
60
]
} |
the nonenzymatic glycation of basement membrane proteins , such as fibronectin and type iv collagen , occurs in diabetes mellitus . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membrane",
"pos": [
30,
47
]
} | {
"id": "C0009333",
"name": "type iv collagen",
"pos": [
83,
99
]
} |
probing the hypothalamus of rats and rabbits revealed that the in vivo release of luteinizing hormone-releasing hormone ( lhrh ) ( frequency and amplitude of the lhrh signal ) can be altered by administration of estrogen to ovariectomized rats ; | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
12,
24
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
162,
166
]
} |
at a non-stimulatory concentration of glucose ( 3 mm ) , 1-adamantanamine ( 1 mm ) reversibly inhibited 86rb efflux from islet cells , depolarized the beta-cell membrane , induced electrical activity , stimulated 45ca uptake and efflux , and triggered insulin release . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "islet cells",
"pos": [
121,
132
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
252,
259
]
} |
a time course study on the changes of rat hypothalamic corticotropin-releasing factor ( crf ) levels and acth levels in plasma , pituitary and hypothalamus after an acute treatment with reserpine was examined using a rat crf ria . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
143,
155
]
} | {
"id": "C0010132",
"name": "crf",
"pos": [
221,
224
]
} |
these results suggest that : acute depletion of hypothalamic norepinephrine levels cause the initial release of crf that stimulates pituitary acth secretion , and the depletion of crf and acth stores at the early stage ; | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
48,
60
]
} | {
"id": "C0010132",
"name": "crf",
"pos": [
180,
183
]
} |
human corticoliberin hypothalamic neuroglandular system : comparative immunocytochemical study with anti-rat and anti-ovine corticotropin-releasing factor sera in the early stages of development . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
21,
33
]
} | {
"id": "C0010132",
"name": "corticotropin-releasing",
"pos": [
124,
147
]
} |
development of the paraventriculo-infundibular corticoliberin system was studied by immunocytochemical analysis of human hypothalamic sections using antisera raised against rat or ovine corticotropin-releasing factor ( crf ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
121,
133
]
} | {
"id": "C0010132",
"name": "corticotropin-releasing factor",
"pos": [
186,
216
]
} |
some hypothalamic peri- and paraventricular neurons , observed from the 12th week , are rat-crf-immunoreactive but not ovine crf-immunoreactive . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
5,
17
]
} | {
"id": "C0010132",
"name": "crf",
"pos": [
125,
128
]
} |
specifically , all structural features of colon epithelial cells were identified , including junction formation , prominent microvilli , and mucin secretion , in several cell lines . | tissue_is_expression_site_of_gene_product | {
"id": "C0014597",
"name": "epithelial cells",
"pos": [
48,
64
]
} | {
"id": "C0026682",
"name": "mucin",
"pos": [
141,
146
]
} |
tbg examination was performed on 42 patients with primary hepatocellular carcinoma ( phc ) and 50 postoperative patients with metastases to the liver . alpha-fetoprotein ( afp ) and carcinoembryonic antigen ( cea ) concentrations were determined at the same time . | tissue_is_expression_site_of_gene_product | {
"id": "C0023884",
"name": "liver",
"pos": [
144,
149
]
} | {
"id": "C0002210",
"name": "alpha-fetoprotein",
"pos": [
152,
169
]
} |
over 90 % of t cell hybridomas prepared from v beta 17a+ t cells of swr mice respond to allogeneic forms of the ie class ii mhc protein , indicating that v beta 17a has an appreciable affinity for ie regardless of the other components of the t cell receptor . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t",
"pos": [
13,
14
]
} | {
"id": "C0034790",
"name": "t cell",
"pos": [
242,
248
]
} |
one aberrant fetus showed early development of the adult pattern in the red cells , having adult type hb and adult levels of ca during the period of 116-128 days of fetal age . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cells",
"pos": [
72,
81
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
102,
104
]
} |
the investigation was prompted by demonstrations that pancreatic islets can secrete insulin in response to a graded glucose challenge after cryopreservation using relatively fast cooling rates which would be expected to be suboptimal for leucocyte survival . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "pancreatic islets",
"pos": [
54,
71
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
84,
91
]
} |
thus , the cold follicles of the old thyroid must have been functioning normally during equilibration of young thyroids , but have then gradually lost their capacity to iodinate and to remove stored tgb from the colloid . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroids",
"pos": [
111,
119
]
} | {
"id": "C0040123",
"name": "tgb",
"pos": [
199,
202
]
} |
it is generally accepted that hypothalamic somatostatin and hepatic insulin-like growth factor i ( igf-i ) /somatomedin-c act directly on the pituitary to inhibit gh release , but it is not known whether all somatotropes are responsive to these agents . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
30,
42
]
} | {
"id": "C0037659",
"name": "somatostatin",
"pos": [
43,
55
]
} |
in higher primates , the protracted delay from infancy to puberty results from an interruption in hypothalamic gnrh release . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
98,
110
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
111,
115
]
} |
to determine whether the quiescent hypothalamic gnrh neurons of the prepubertal macaque are capable of discharging the decapeptide in response to a generalized neural depolarization , an excitatory amino acid analog , n-methyl-d , l-aspartate ( nma ) , was administered systemically to orchidectomized rhesus monkeys between 13 and 20 months of age . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
35,
47
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
48,
52
]
} |
taken together these findings demonstrate that the apparent dormancy of hypothalamic gnrh neurons , which is characteristic of prepubertal development in higher primates and underlies the protracted delay in the onset of puberty in these species , may be readily terminated by application of a generalized neural excitation . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
72,
84
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
85,
89
]
} |
immunoreactive levels of avp and oxt in the hypothalamus were unaffected by hypophysectomy , though total srif-like immunoreactivity was depressed . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
44,
56
]
} | {
"id": "C0037659",
"name": "srif",
"pos": [
106,
110
]
} |
the accumulation of a platelet protein , thrombospondin , at the site of arterial thrombus formation : preliminary report . | tissue_is_expression_site_of_gene_product | {
"id": "C0005821",
"name": "platelet",
"pos": [
22,
30
]
} | {
"id": "C0076560",
"name": "thrombospondin",
"pos": [
41,
55
]
} |
to compare and contrast the human t cell antigen receptor ( tcr ) alpha and beta chain messages found in human thymocytes to those previously isolated from human peripheral blood t lymphocytes and other nonthymic sources , 13 tcr alpha and 13 tcr beta cdna were isolated from a human thymocyte library and the nucleotide sequences were determined . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t lymphocytes",
"pos": [
179,
192
]
} | {
"id": "C0034790",
"name": "tcr",
"pos": [
243,
246
]
} |
the data indicate that , as was found in the peripheral t lymphocytes , the majority of the tcr alpha and tcr beta chain thymocyte cdna were derived from potentially functional messages . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t lymphocytes",
"pos": [
56,
69
]
} | {
"id": "C0034790",
"name": "tcr",
"pos": [
106,
109
]
} |
in contrast , antigen- and ia-independent t cell triggering induced by appropriate mab to the thy-1 or the t cell receptor molecules were found to be inhibitable by l3t4a- but not lfa-1a-specific mab , although the extent of inhibition varied , depending on the cell type and the activating signal examined . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cell",
"pos": [
42,
48
]
} | {
"id": "C0034790",
"name": "t cell receptor",
"pos": [
107,
122
]
} |
three cultured human cell lines , renal cancer cells ( achn ) , bladder cancer cells ( ej ) , and fibroblasts transformed in culture by co-60 gamma rays ( kmst-6 ) , when treated with interferon-beta , produced 1.5 to 4 times as much plasminogen activator as the untreated control cultures . | tissue_is_expression_site_of_gene_product | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
98,
109
]
} | {
"id": "C0015980",
"name": "interferon-beta",
"pos": [
184,
199
]
} |
this study was designed to assess whether the hypothalamic action of clomiphene citrate ( cc ) on gonadotropin-releasing hormone ( gnrh ) neurons required activity of opiate neurons . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
46,
58
]
} | {
"id": "C0023610",
"name": "gonadotropin-releasing hormone",
"pos": [
98,
128
]
} |
it is hypothesized that an increase of hypothalamic estrogen production because of local androstenedione aromatization might be responsible for the luteinizing hormone-releasing hormone block observed in these patients . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
39,
51
]
} | {
"id": "C0023610",
"name": "luteinizing hormone-releasing hormone",
"pos": [
148,
185
]
} |
the study shows that the pancreatic islet abnormalities in iron overloaded diabetic patients are completely different from those of type 1 ( insulin-dependent ) and type 2 ( non-insulin-dependent ) diabetic patients . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "pancreatic islet",
"pos": [
25,
41
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
178,
185
]
} |
six male patients ( aged 21-34 years ) with isolated hypothalamic hypogonadism were given subcutaneous pulses of gonadotrophin-releasing hormone every 90 min for 14-74 weeks . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
53,
65
]
} | {
"id": "C0023610",
"name": "gonadotrophin-releasing hormone",
"pos": [
113,
144
]
} |
t lymphocytes of higher vertebrates are able to specifically recognize a seemingly unlimited number of foreign antigens via their receptors , the t cell antigen receptors ( tcrs ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t lymphocytes",
"pos": [
0,
13
]
} | {
"id": "C0034790",
"name": "tcrs",
"pos": [
173,
177
]
} |
t lymphocytes mature by passing through the thymus and acquire antigen specificity by expressing the tcr molecules on their cell surface . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t lymphocytes",
"pos": [
0,
13
]
} | {
"id": "C0034790",
"name": "tcr",
"pos": [
101,
104
]
} |
formol-fixed and paraffin-embedded material was reconstituted and stained with antibodies against epithelial cells ( keratin , epithelial membrane antigen , carcinoembryonic antigen ) , mesenchymal and histiocytic cells ( vimentin , alpha-1-antichymotrypsin , alpha-1-antitrypsin , lysozyme ) , nerve tissue ( neurofilament , glial fibrillary acidic protein , myelin basic protein , myelin-associated protein , neuron-specific enolase ) , vessels ( factor-viii-related protein ) , basal cell lamina ( laminin ) and s-100 protein . | tissue_is_expression_site_of_gene_product | {
"id": "C0014597",
"name": "epithelial cells",
"pos": [
98,
114
]
} | {
"id": "C0007082",
"name": "carcinoembryonic antigen",
"pos": [
157,
181
]
} |
these findings indicate that the initiation of folliculogenesis for the ensuing cycle occurs during the late luteal phase by a process of selective augmentation in fsh secretion independent of hypothalamic gnrh secretion . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
193,
205
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
206,
210
]
} |
extracts of human ovaries as well as rat ovaries , rat hypothalami , and rat plasma were examined for their content of both gnrh-like protein and gnrh . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalami",
"pos": [
55,
66
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
146,
150
]
} |
precise oxygen equilibria including extreme , high and low saturation values were determined for hemoglobin ( hb ) from the freshwater teleost tinca tinca at three temperatures , each at two ph levels and in the presence and absence of the erythrocytic cofactor atp , at twofold molar excess over hb . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocytic",
"pos": [
240,
252
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
297,
299
]
} |
atp greatly depresses the temperature sensitivity of oxygenation particularly at physiological erythrocytic ph , where endothermic cofactor dissociation finds expression in a reverse temperature sensitivity for binding of the 3rd oxygen molecule to the tetrameric hb . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocytic",
"pos": [
95,
107
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
264,
266
]
} |
the allosteric effects of the erythrocytic nucleoside triphosphates ( ntp ) and of proton concentrations were investigated by precise measurement of hb-o2 equilibria of tench hemoglobin ( including extreme , high and low saturation ranges ) and analysed in terms of the mwc two state model and the adair four step oxygenation theory . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocytic",
"pos": [
30,
42
]
} | {
"id": "C0030069",
"name": "hb-o2",
"pos": [
149,
154
]
} |
human non-malignant and malignant brain tumor derived cell cultures : proliferation and sensitivity to natural human fibroblast ( beta ) interferon . | tissue_is_expression_site_of_gene_product | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
117,
127
]
} | {
"id": "C0015980",
"name": "beta",
"pos": [
130,
134
]
} |
this provides support for the hypothesis that , during lactation , beta-endorphin acts within the hypothalamus to reduce gnrh release and hence depress pituitary gonadotrophin secretion . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
98,
110
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
121,
125
]
} |
this suggests that hypothalamic activity responds to photoperiod and that changes in pituitary responsiveness to lhrh and steroid negative feedback are unimportant . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
19,
31
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
113,
117
]
} |
ducts with marked atypicality and invasive pancreatic carcinomas frequently exhibited discontinuous basement membrane staining for fib , which often paralleled loss of staining for the integral basement membrane proteins -- type iv collagen and laminin . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membrane",
"pos": [
100,
117
]
} | {
"id": "C0009333",
"name": "type iv collagen",
"pos": [
224,
240
]
} |
red cells with schizonts do not possess a higher proportion of met-hb than non-parasitized erythrocytes . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cells",
"pos": [
0,
9
]
} | {
"id": "C0025635",
"name": "met-hb",
"pos": [
63,
69
]
} |
it is concluded that the presence of liver cell dysplasia identifies a group of patients with a high risk of liver cell carcinoma and that they should be followed up by serial alpha-fetoprotein estimations . | tissue_is_expression_site_of_gene_product | {
"id": "C0023884",
"name": "liver",
"pos": [
37,
42
]
} | {
"id": "C0002210",
"name": "alpha-fetoprotein",
"pos": [
176,
193
]
} |
obtention of antisera against a hypothalamic decapeptide ( luteinizing hormone-follicle stimulating hormone releasing hormone ) which stimulated the release of pituitary gonadotropins and development of its radioimmunoassay . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
32,
44
]
} | {
"id": "C0023610",
"name": "luteinizing",
"pos": [
59,
70
]
} |
reduced red cell 2,3-diphosphoglycerate and adenosine triphosphate , hypophosphatemia , and increased hemoglobin-oxygen affinity after cardiac surgery . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cell",
"pos": [
8,
16
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
102,
112
]
} |
formation of ( 13 ) c-resonances attributable to carbamino derivatives has been observed in human erythrocyte hemolysate preparations equilibrated with ( 13 ) co ( 2 ) at 33 degrees . carbamino formation is most marked in deoxyhemoglobin and at alkaline ph , and is very largely inhibited by the addition of 2,3-diphosphoglycerate or conversion to oxyhemoglobin . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
98,
109
]
} | {
"id": "C0030069",
"name": "oxyhemoglobin",
"pos": [
348,
361
]
} |
[ in vitro action of hypothalamic luteinizing hormone releasing factor ( irf ) on lamb anterior pituitary . i. kinetics of excretion of luteinizing hormone ( lh ) ] . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
21,
33
]
} | {
"id": "C0023610",
"name": "luteinizing hormone releasing factor",
"pos": [
34,
70
]
} |
[ in vitro action of hypothalamic luteinizing hormone releasing factor ( irf ) on lamb anterior pituitary . ii . ultrastructural study of incubated tissues ] . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
21,
33
]
} | {
"id": "C0023610",
"name": "luteinizing hormone releasing factor",
"pos": [
34,
70
]
} |
conformational studies on human and rabbit plasma hemopexin and on the effect of ligands on the rabbit heme-hemopexin complex . | tissue_is_expression_site_of_gene_product | {
"id": "C0032105",
"name": "plasma",
"pos": [
43,
49
]
} | {
"id": "C0019067",
"name": "hemopexin",
"pos": [
108,
117
]
} |
under such treatment the blood pressure soon began to show a progressive rise , the volume increased , and the red cells became more evenly redistributed , as shown by the relative hemoglobin percentages of the capillary and venous blood . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cells",
"pos": [
111,
120
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
181,
191
]
} |
the above findings suggest a possible role for the high cholesterol content and preferential localization of phosphatidylserine in the inner bilayer leaflet of erythrocyte membrane in protecting against hb-induced lipid peroxidation in the membrane . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
160,
171
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
203,
205
]
} |
we also show that antiserum to ifn-beta enhanced the mitogenic effect of tnf in confluent , serum-starved human fibroblasts , suggesting that induction of ifn-beta by tnf represents a physiological negative feedback mechanism regulating cell proliferation . | tissue_is_expression_site_of_gene_product | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
112,
123
]
} | {
"id": "C0015980",
"name": "ifn-beta",
"pos": [
155,
163
]
} |
in pancreatic islets removed from 48 h-fasted rats , as distinct from fed animals , the release of insulin evoked by d-glucose is more severely impaired than that evoked by 2-ketoisocaproate . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "pancreatic islets",
"pos": [
3,
20
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
99,
106
]
} |
[ role of alpha-adrenoreceptors of the hypothalamus and amygdala in the response of the secretory glands of the stomach to neurotensin and somatostatin ] . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
39,
51
]
} | {
"id": "C0037659",
"name": "somatostatin",
"pos": [
139,
151
]
} |
the ovnis 6h and 5h thyroid cells , 2 permanent cell lines isolated 3 years ago from ovine tissue , synthesize a high molecular weight glycosylated protein , immunologically related to ovine thyroglobulin , which is similar to the prothyroid hormone dimer ( 17-19 ) s : thyroglobulin . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
20,
27
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
270,
283
]
} |
af was also shown to have a mitogenic activity on rat t lymphocytes , and to stimulate them to produce a lymphokine chemotactic for macrophages . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocytes",
"pos": [
56,
67
]
} | {
"id": "C0024297",
"name": "lymphokine",
"pos": [
105,
115
]
} |
thyroglobulin glycopeptides were analyzed by sequential affinity chromatography on immobilized lectins and compared to chemically labeled carbohydrate chains released from thyroid-derived thyroglobulin by hydrazinolysis . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
172,
179
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
188,
201
]
} |
isolation and characterization of a new peptide from hypothalamus and pituitary using a monoclonal antibody to lhrh . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
53,
65
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
111,
115
]
} |
a new peptide with lhrh-like immunoreactivity has been isolated from rat hypothalamus and pituitary using an immunosorbent prepared with monoclonal antibody to luteinizing hormone-releasing hormone ( lhrh ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
73,
85
]
} | {
"id": "C0023610",
"name": "luteinizing hormone-releasing hormone",
"pos": [
160,
197
]
} |
monocytes play a mandatory accessory role in this process , because purified t lymphocytes failed to produce ifn-gamma in response to lps and the addition of 2 % monocytes to t cell cultures resulted in an optimal lps-induced ifn-gamma production . | tissue_is_expression_site_of_gene_product | {
"id": "C0026473",
"name": "monocytes",
"pos": [
0,
9
]
} | {
"id": "C0108768",
"name": "2",
"pos": [
158,
159
]
} |
stimulation of these cloned ctl with t cell-depleted allogeneic spleen cells , allogeneic tumor cells , or immobilized mab reactive with the t cell antigen receptor ( tcr ) induced thymidine incorporation , entry into cell cycle , and secretion of macrophage activating factor , but these stimuli did not induce the secretion of il-2 . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cell",
"pos": [
37,
43
]
} | {
"id": "C0034790",
"name": "tcr",
"pos": [
167,
170
]
} |
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