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|---|---|---|---|
our results suggest that induction and maintenance of spermatogenesis as well as fertility in hypothalamic hypogonadism can be achieved with in gnrh therapy if pituitary and testicular function are intact . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
94,
106
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
144,
148
]
} |
the hypothalamus receives a rich supply of adrenergic and noradrenergic nerve fibres from the brain stem , terminating in many hypothalamic regions , including the paraventricular nucleus , which is the site of the cell bodies of corticotrophin releasing factor ( crf ) neurones in man . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
127,
139
]
} | {
"id": "C0010132",
"name": "corticotrophin releasing factor",
"pos": [
230,
261
]
} |
the immune response to pepsin-soluble human basement membrane-derived type iv collagen in mice has been characterized . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membrane",
"pos": [
44,
61
]
} | {
"id": "C0009333",
"name": "type iv",
"pos": [
70,
77
]
} |
platelet thrombospondin and an unidentified but biologically similar plasma protein were shown to inhibit the gelatin-binding activity of fibronectin . | tissue_is_expression_site_of_gene_product | {
"id": "C0005821",
"name": "platelet",
"pos": [
0,
8
]
} | {
"id": "C0076560",
"name": "thrombospondin",
"pos": [
9,
23
]
} |
these data demonstrated that platelet-released thrombospondin was responsible for the reduction in fibronectin gelatin-binding activity seen in serum . | tissue_is_expression_site_of_gene_product | {
"id": "C0005821",
"name": "platelet",
"pos": [
29,
37
]
} | {
"id": "C0076560",
"name": "thrombospondin",
"pos": [
47,
61
]
} |
this investigation is an approach to the study of in vivo relationships between basement membrane components ( type iv collagen , laminin ) and neoplastic cells of hepatocellular carcinoma . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membrane",
"pos": [
80,
97
]
} | {
"id": "C0009333",
"name": "type iv collagen",
"pos": [
111,
127
]
} |
perturbation of the endogenous opioid peptide system in the ewe by naloxone therefore increases the secretion of hypothalamic gnrh into the hypophysial portal vasculature . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
113,
125
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
126,
130
]
} |
however , three aniline metabolites -- phenylhydroxylamine , 2-aminophenol , and 4-aminophenol -- catalyze methemoglobin formation in erythrocyte suspensions and , hence , could contribute to methemoglobin formation in vivo after aniline . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
134,
145
]
} | {
"id": "C0025635",
"name": "methemoglobin",
"pos": [
192,
205
]
} |
the hypothalamic peptide growth hormone-releasing factor ( grf ) regulates the secretion and production of growth hormone from the anterior pituitary ( m . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
4,
16
]
} | {
"id": "C0037668",
"name": "growth hormone-releasing factor",
"pos": [
25,
56
]
} |
t cells develop from prothymocytes which express no detectable antigen receptors to immature thymocytes with few receptors , eventually becoming mature thymocytes and peripheral t cells with 20,000-40,000 receptors per cell . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
0,
7
]
} | {
"id": "C0034790",
"name": "t cells",
"pos": [
178,
185
]
} |
the result may indicate that the elimination of feedback actions of gh and/or tsh on the hypothalamus led to the decreased synthesis and/or the release of somatostatin . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
89,
101
]
} | {
"id": "C0037659",
"name": "somatostatin",
"pos": [
155,
167
]
} |
morphology of rbc and wbc , total differential count , the number of rbc and wbc , hb contents , pcv , mcv , mch , mchc , esr , haemin crystal structures , coagulation and prothrombin time , glucose and cholesterol contents were calculated and compared with the haematological data recorded for other birds and vertebrates . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "rbc",
"pos": [
14,
17
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
83,
85
]
} |
the mean rbc number and hb content were also more than in fishes , amphibians and reptiles but little less than in man . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "rbc",
"pos": [
9,
12
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
24,
26
]
} |
the rbc number for males of both the species do not differ significantly but the hb contents in males and females of p. benghalensis differ significantly but this was not found in p. philippinus . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "rbc",
"pos": [
4,
7
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
81,
83
]
} |
in normal subjects ( 41 men and 30 women ) the mean red cell 2,3-dpg was 14-5 mol/g haemoglobin ( range 12-1-18-1 mol/g haemoglobin ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cell",
"pos": [
52,
60
]
} | {
"id": "C0019046",
"name": "haemoglobin",
"pos": [
120,
131
]
} |
comparative studies of red cells 2 , 3 diphosphoglycerate ( dpg ) and its effect on hemoglobin oxygen affinity from a taxonomically diverse set of mammals indicate two anomalous groups : members of the superfamilies bovoidea ( actiodactyla ) and feloidea ( carnivora ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cells",
"pos": [
23,
32
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
84,
94
]
} |
serial dilutions of rat hypothalamic extract and varying aliquots of normal rat serum are parallel to the standard curve ( synthetic lh-rh : 0-100 pg/tube ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
24,
36
]
} | {
"id": "C0023610",
"name": "lh-rh",
"pos": [
133,
138
]
} |
the hypothalamic lh-rh content began to decrease in the castrated group after 4 days and fell progressively thereafter . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
4,
16
]
} | {
"id": "C0023610",
"name": "lh-rh",
"pos": [
17,
22
]
} |
however , the hypothalamic lh-rh content of the castrated group maintained with constant levels of testosterone showed no such reduction at any time following castration . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
14,
26
]
} | {
"id": "C0023610",
"name": "lh-rh",
"pos": [
27,
32
]
} |
these experiments indicate that circulating testosterone in physiological concentrations can maintain a normal hypothalamic lh-rh content and demonstrate an action of testosterone , in physiological concentrations , in the feedback regulation of lh-rh secretion . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
111,
123
]
} | {
"id": "C0023610",
"name": "lh-rh",
"pos": [
246,
251
]
} |
on the same model , the present study has investigated the effect of lymphocyte preincubation with supernates obtained in short term cultures from human lymphocytes prestimulated with pha ( lymphokines ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocytes",
"pos": [
153,
164
]
} | {
"id": "C0024297",
"name": "lymphokines",
"pos": [
190,
201
]
} |
this behaviour may be due to the tendency to merge together of two or more colonies in a single giant colony , and supports the interpretation that immune-competent lymphocytes activated either with pha or with lymphokines may stimulate spleen colony growth and erythroid differentiation , though at different extents . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocytes",
"pos": [
165,
176
]
} | {
"id": "C0024297",
"name": "lymphokines",
"pos": [
211,
222
]
} |
lymphocyte release , on stimulation , phlogogenic substances ( lymphokines ) which are responsible for some phlogistic processes , above all chronic . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocyte",
"pos": [
0,
10
]
} | {
"id": "C0024297",
"name": "lymphokines",
"pos": [
63,
74
]
} |
[ effect of oral contraceptive on the pituitary and plasma l.h . levels and on the hypothalamic lh-rh level ( author 's transl ) ] . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
83,
95
]
} | {
"id": "C0023610",
"name": "lh-rh",
"pos": [
96,
101
]
} |
the effects of the oral contraceptive on the pituitary content and plasma level of lh and the hypothalamic lh-rh level were investigated in 16 adult female rabbits . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
94,
106
]
} | {
"id": "C0023610",
"name": "lh-rh",
"pos": [
107,
112
]
} |
plasma level and the pituitary content of lh and the hypothalamic lh-rh were measured by radioimmunoassay . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
53,
65
]
} | {
"id": "C0023610",
"name": "lh-rh",
"pos": [
66,
71
]
} |
it has been assumed that oral contraceptive drugs exert their action by blocking the hypothalamic lh-rh , resulting in a depression of the plasma level of lh , because plasma level of lh returned to the normal level when lh-rh was administered intravenously even while oral contraceptive steroids were given continuously . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
85,
97
]
} | {
"id": "C0023610",
"name": "lh-rh",
"pos": [
221,
226
]
} |
detailed mechanisms on how the hypothalamic lh-rh was increased were not known in this experiment , further investigations are now in progress . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
31,
43
]
} | {
"id": "C0023610",
"name": "lh-rh",
"pos": [
44,
49
]
} |
in dose and time schedule used in this study , it is inferred that estrogen and progesterone may exert their direct effect to hypothalamus on endogenous lh-rh secretion and also may exert their effect on pituitary gonadotrophs to change the sensitivity to lh-rh , i.e . these steroid hormones may be major factors in the control of gonadotropin release in the baboon . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
126,
138
]
} | {
"id": "C0023610",
"name": "lh-rh",
"pos": [
256,
261
]
} |
the results suggest a reactivity of distinct classes of antibodies in serums of patients with type i diabetes to disparate antigens on human islet cells and cloned rat insulinoma cells and , moreover , reactivity to insulin as the secreted product . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "islet cells",
"pos": [
141,
152
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
216,
223
]
} |
the mean activity ( +/- sd ) of ada fresh red cells was 1.29 +/- 0.36 u/g hb , after 2 h incubation in app medium it was 1.71 +/- 0.38 u/g hb , and after 2 h incubation in appd medium an activity of 2.68 +/- 0.95 u/g hb was found . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cells",
"pos": [
42,
51
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
217,
219
]
} |
circle rotation of animals is induced by hypothalamic neurohormones ( somatostatin , lh-rh , substance p , and trh ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
41,
53
]
} | {
"id": "C0037659",
"name": "somatostatin",
"pos": [
70,
82
]
} |
circle rotation of animals is induced by hypothalamic neurohormones ( somatostatin , lh-rh , substance p , and trh ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
41,
53
]
} | {
"id": "C0023610",
"name": "lh-rh",
"pos": [
85,
90
]
} |
t cells from patients successfully treated with okt3 do not react with the t-cell receptor antibody . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
0,
7
]
} | {
"id": "C0034790",
"name": "t-cell receptor",
"pos": [
75,
90
]
} |
as an extension of our previous reports that cardiac and skeletal muscle troponin i ( tn-i ) and troponin t ( tn-t ) are excellent substrates for protein kinase c ( pkc ) ( katoh , n. , wise , b. c. , and kuo , j. f. ( 1983 ) biochem . j . 209 , 189-195 ; mazzei , g. j. , and kuo , j. f. ( 1984 ) biochem . j . 218 , 361-369 ) , we have now determined that pkc phosphorylated serine 43 ( and/or serine 45 ) , serine 78 , and threonine 144 in the free tn-i subunit and threonine 190 , threonine 199 , and threonine 280 in the free tn-t subunit of bovine cardiac troponin . | tissue_is_expression_site_of_gene_product | {
"id": "C0018787",
"name": "cardiac",
"pos": [
45,
52
]
} | {
"id": "C3538889",
"name": "tn-t",
"pos": [
531,
535
]
} |
none of the generated t cell hybridomas exhibited antigen-specific il-2 secretion when stimulated with autologous thyrocytes , although 60 % of the hybridomas expressed cd3 antigen and the t cell receptor alpha/beta heterodimer . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cell",
"pos": [
22,
28
]
} | {
"id": "C0085247",
"name": "t cell receptor alpha/beta",
"pos": [
189,
215
]
} |
immunoprecipitation of a cell membrane fraction from cd3+ , dn t cells with anti-delta tcr antibody isolated a 45-kda band . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
63,
70
]
} | {
"id": "C0034790",
"name": "tcr",
"pos": [
87,
90
]
} |
in a first step a 5-fluorouracil ( 5-fu ) -sensitive t cell recognizes the parental bone marrow cells and stimulates a macrophage-like cell to secrete ifn-alpha/beta ( recognition phase ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0024432",
"name": "cell",
"pos": [
55,
59
]
} | {
"id": "C0015980",
"name": "ifn",
"pos": [
151,
154
]
} |
this antiserum specifically immunoprecipitated 41-kda tcr v gamma-c gamma 4 chains and 31-kda tcr v gamma-c gamma 1/2 chains from distinct heterodimers expressed on the tcr-gamma delta t cell hybridomas . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "tcr",
"pos": [
54,
57
]
} | {
"id": "C0085246",
"name": "tcr-gamma delta",
"pos": [
169,
184
]
} |
self tolerance induction in the thymus is known to delete t cells expressing certain v beta tcr molecules . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
58,
65
]
} | {
"id": "C0034790",
"name": "tcr",
"pos": [
92,
95
]
} |
the b-cell-specific ( otf-2 ) and ubiquitous ( otf-1 ) octamer-binding transcription factors specifically bound to a site centered about 136 bp 5 ' of the nuclear factor nf-kappa b site . | tissue_is_expression_site_of_gene_product | {
"id": "C0004561",
"name": "b-cell",
"pos": [
4,
10
]
} | {
"id": "C1442823",
"name": "otf-2",
"pos": [
22,
27
]
} |
the effects of thyroxine ( t4 ) on growth , feed efficiency , breast muscle ( musculus pectoralis profundus ) weight , liver weight , abdominal fat content , and rates of muscle protein synthesis ( ks ) and breakdown ( kd ) estimated by n tau-methylhistidine excretion were investigated in broiler chickens of both sexes . | tissue_is_expression_site_of_gene_product | {
"id": "C0026845",
"name": "musculus",
"pos": [
78,
86
]
} | {
"id": "C0026832",
"name": "muscle protein",
"pos": [
171,
185
]
} |
the findings in the present investigation suggested that the improved feed efficiency and muscle growth were largely accomplished by the increase in muscle protein synthesis induced by the dietary inclusion of thyroxine . | tissue_is_expression_site_of_gene_product | {
"id": "C0026845",
"name": "muscle",
"pos": [
90,
96
]
} | {
"id": "C0026832",
"name": "muscle protein",
"pos": [
149,
163
]
} |
t cell hybridomas that express the t cell antigen receptor ( tcr ) zeta homodimer ( zeta 2 ) , but not the tcr zeta eta heterodimer , were studied . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cell",
"pos": [
0,
6
]
} | {
"id": "C0034790",
"name": "tcr",
"pos": [
107,
110
]
} |
the co-induced increase in the corpuscular elements of blood ( erythrocytes ) , the influence on other parameters ( such as rbc volume , haemoglobin , haematocrit , blood and plasma viscosity , tendency of erythrocytes and platelets to aggregate , fibrinogen level etc . ) , as well as the increase in catecholamine level are taken to be reversible . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "rbc",
"pos": [
124,
127
]
} | {
"id": "C0019046",
"name": "haemoglobin",
"pos": [
137,
148
]
} |
growing male lambs were fed with diets containing 14.0 , 10.8 and 7.6 % protein for 3 months to determine their effects on the content of hypothalamic lhrh and srih and pituitary lh and gh , using immunohistochemical methods . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
138,
150
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
151,
155
]
} |
it seems that they suppress lhrh/lh release and augment gh release , possibly via suppression of hypothalamic somatostatin . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
97,
109
]
} | {
"id": "C0037659",
"name": "somatostatin",
"pos": [
110,
122
]
} |
thermal stress reduces serum luteinizing hormone and bioassayable hypothalamic content of luteinizing hormone-releasing hormone in hens . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
66,
78
]
} | {
"id": "C0023610",
"name": "luteinizing hormone-releasing hormone",
"pos": [
90,
127
]
} |
i have compared the quantity and the length of the poly ( a ) tracts of five haploid-expressed mrnas in the polysomal and nonpolysomal fractions of round and elongating spermatids in mice : transition proteins 1 and 2 , protamines 1 and 2 , and an unidentified mrna of about 1050 bases . | tissue_is_expression_site_of_gene_product | {
"id": "C0037857",
"name": "spermatids",
"pos": [
169,
179
]
} | {
"id": "C0146524",
"name": "transition proteins 1",
"pos": [
190,
211
]
} |
one domain is on the 70-kda core fragment , probably similar to that of platelet thrombospondin . | tissue_is_expression_site_of_gene_product | {
"id": "C0005821",
"name": "platelet",
"pos": [
72,
80
]
} | {
"id": "C0076560",
"name": "thrombospondin",
"pos": [
81,
95
]
} |
the other domain is on the 27-kda n-terminal fragment and is unique to endothelial cell thrombospondin . | tissue_is_expression_site_of_gene_product | {
"id": "C0225336",
"name": "endothelial cell",
"pos": [
71,
87
]
} | {
"id": "C0076560",
"name": "thrombospondin",
"pos": [
88,
102
]
} |
our data suggest that endothelial-cell thrombospondin possesses two distinct binding sites for fibronectin , a low-affinity constitutively available one and a high-affinity one , possibly sequestered on the intact unbound molecule . | tissue_is_expression_site_of_gene_product | {
"id": "C0225336",
"name": "endothelial-cell",
"pos": [
22,
38
]
} | {
"id": "C0076560",
"name": "thrombospondin",
"pos": [
39,
53
]
} |
acute exposure of pancreatic islets to interleukin-1 beta results in an increase in insulin release , while an extension of the exposure time induces a functional suppression and eventually , destruction of the b-cells . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "pancreatic islets",
"pos": [
18,
35
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
84,
91
]
} |
in isolated rat pancreatic islets exogenous glutathione which is not able to penetrate into cells , augmented glucose ( 11.1 mmol/l ) -mediated insulin release . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "pancreatic islets",
"pos": [
16,
33
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
144,
151
]
} |
islet-like structures with insulin-immunoreactive ( ir ) cells surrounded by glucagon-ir cells were observed only in the splenic portion of the pancreas of m. caspica . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "islet",
"pos": [
0,
5
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
27,
34
]
} |
these results strengthen the view that hypothalamic da and 5-ht play a role in the regulation of the preovulatory release of lh by a reduction in inhibitory inputs on lhrh neurones . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
39,
51
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
167,
171
]
} |
a patient , who had developed anergy after disseminated histoplasmosis and who had gone on to develop a cardiomyopathy , demonstrated an unusually large proportion of t lymphocytes bearing the gamma and delta chains of the t cell receptor ( tcr-gamma/delta ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t lymphocytes",
"pos": [
167,
180
]
} | {
"id": "C0034790",
"name": "t cell",
"pos": [
223,
229
]
} |
a patient , who had developed anergy after disseminated histoplasmosis and who had gone on to develop a cardiomyopathy , demonstrated an unusually large proportion of t lymphocytes bearing the gamma and delta chains of the t cell receptor ( tcr-gamma/delta ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t lymphocytes",
"pos": [
167,
180
]
} | {
"id": "C0085246",
"name": "tcr-gamma/delta",
"pos": [
241,
256
]
} |
the interaction of human platelet thrombospondin ( tsp ) with human platelet glycoproteins gpiib-iiia was studied using a solid-phase binding assay . | tissue_is_expression_site_of_gene_product | {
"id": "C0005821",
"name": "platelet",
"pos": [
25,
33
]
} | {
"id": "C0076560",
"name": "thrombospondin",
"pos": [
34,
48
]
} |
eight days after infection , mcmv-primed local lymph node t cells were either depleted for t cells expressing a v beta 8+ tcr or separated into v beta 8+ and v beta 8- subpopulations by a cell sorter using the mab f23.1 . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
58,
65
]
} | {
"id": "C0034790",
"name": "tcr",
"pos": [
122,
125
]
} |
specifically , blood specimens were drawn to estimate rbc , wbc , hb , hct , mcv , mch and mchc values by coulter counter model s7 , while platelet value was estimated by ultra flo 100 . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "rbc",
"pos": [
54,
57
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
66,
68
]
} |
the results are presented follows : ( 1 ) the differences are non-significant in rbc , wbc , hb and mch between the venous blood [ 453.74 +/- 85.4 ) x 10 ( 4 ) /cmm , 8290 +/- 4074/cmm 13.53 +/- 2.42 ( gm % ) , 30.23 +/- 2.55 ( pg ] and the capillary blood [ 463.14 +/- 94.57 ) x 10 ( 4 ) /cm 8182 +/- 4268/cm , 13.82 +/- 2.61 ( gm % ) , 30.12 +/- 2.21 ( pg ] . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "rbc",
"pos": [
81,
84
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
93,
95
]
} |
we observed a decrease of the concentration of alpha 2-globulins , which indicates inhibition of the synthetic activity of the liver , and an increase of that of beta-globulins , which suggests an adverse effect of head-down tilt on lipid metabolism . | tissue_is_expression_site_of_gene_product | {
"id": "C0023884",
"name": "liver",
"pos": [
127,
132
]
} | {
"id": "C0005157",
"name": "beta-globulins",
"pos": [
162,
176
]
} |
cd4+ cells stimulated with mitogen and hla-dr positive accessory cells produced measurable levels of il-2 that were completely inhibited by 1,25-d3 . | tissue_is_expression_site_of_gene_product | {
"id": "C0039215",
"name": "cd4",
"pos": [
0,
3
]
} | {
"id": "C0019764",
"name": "hla-dr",
"pos": [
39,
45
]
} |
t lymphocytes recognize antigens by means of t-cell receptors ( tcr ) composed of alpha beta or gamma delta heterodimers . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t lymphocytes",
"pos": [
0,
13
]
} | {
"id": "C0034790",
"name": "antigens",
"pos": [
24,
32
]
} |
the results suggest that intraventricular injection of colchicine is a stressful stimulus and support the view that several catecholamine cell groups in the lower brainstem are part of the brain circuitry mediating stress reactions , as are the hypothalamic neurons that contain corticotropin-releasing factor . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
245,
257
]
} | {
"id": "C0010132",
"name": "corticotropin-releasing",
"pos": [
279,
302
]
} |
in experiments using antibodies against human platelet alpha-granule proteins , thrombin stimulated platelet deposition in uncoated glass capillaries was inhibited at 2,000 s-1 by anti-vwf and to a lesser extent by anti-fibrinogen but not by anti-thrombospondin antibodies . | tissue_is_expression_site_of_gene_product | {
"id": "C0005821",
"name": "platelet",
"pos": [
46,
54
]
} | {
"id": "C0076560",
"name": "thrombospondin",
"pos": [
247,
261
]
} |
iron status was assessed using a combination of several biochemical indicators ( serum ferritin , erythrocyte protoporphyrin , serum iron , mcv , hemoglobin ) in 3,676 apparently healthy children . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
98,
109
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
146,
156
]
} |
the adhesion of wbcs on surface hydroxyl group-bearing polymers proceeded via the cr3 receptor-c3b ligand interaction , in which activated complement factor c3b is chemically fixed upon complement activation . | tissue_is_expression_site_of_gene_product | {
"id": "C0023516",
"name": "wbcs",
"pos": [
16,
20
]
} | {
"id": "C0079785",
"name": "cr3",
"pos": [
82,
85
]
} |
evidence from our laboratory suggests that the hypothalamic impairment compromises regulation of the endogenous opioid system engendering a persistent opiatergic suppression of gonadotropin-releasing hormone secretion , which is subsequently reflected in a chronically low pituitary content of gonadotropin-releasing hormone receptors . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
47,
59
]
} | {
"id": "C0023610",
"name": "gonadotropin-releasing hormone",
"pos": [
294,
324
]
} |
in this respect , the pattern of expression of the mhcs recognized by our mabs in developing , fast muscle is very similar to the patterns described for other muscle contractile proteins . | tissue_is_expression_site_of_gene_product | {
"id": "C0026845",
"name": "muscle",
"pos": [
100,
106
]
} | {
"id": "C0026832",
"name": "muscle",
"pos": [
159,
165
]
} |
hypothalamic grf content does not increase under tyrosine treatment in male fetuses , whereas in female fetuses the stress-induced increase of grf content was rather pronounced under tyrosine than attenuated . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
0,
12
]
} | {
"id": "C0023610",
"name": "grf",
"pos": [
143,
146
]
} |
these results indicate that fetal hypothalamic neurotransmitters and neurohormones ( such as lh-rh , crf , grf and opioids ) are involved in changing circulating hypophysial and adrenal hormones in fetuses exposed to maternal stress in late pregnancy , whereby sex-specific different pathways might be effective in fetal stress processing . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
34,
46
]
} | {
"id": "C0023610",
"name": "grf",
"pos": [
107,
110
]
} |
increase in concentration produced a dose dependent increase in rbcs ( 0.87 x 10 ( 6 ) to 1.63 x 10 ( 6 ) /mm3 ) , wbcs ( 0.070 x 10 ( 6 ) to 0.520 x 10 ( 6 ) /mm3 ) , hemoglobin ( 3.7 to 5.6 % ) and hematocrit ( 9.0 to 12.3 % ) and a decrease in mcv ( 111.8 to 88.2 microns 3 ) , mchc ( 41.05 to 31.35 % ) and mch ( 44.2 to 33.9 pg ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "rbcs",
"pos": [
64,
68
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
168,
178
]
} |
cyclosporin a decreases lymphocyte accumulation only through its ability to suppress lymphokine production , while inhibitors of arachidonate metabolism have little direct effect on lymphocyte migration . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocyte",
"pos": [
24,
34
]
} | {
"id": "C0024297",
"name": "lymphokine",
"pos": [
85,
95
]
} |
therefore to characterize the pattern of postburn lymphocyte dysfunction , the rates of the patient 's spontaneous ( sbt ) and stimulated ( mitogen phytohemagglutinin ) lymphocyte blastogenesis were measured and correlated with the biologic effect of the patient 's serum and lymphokines on control mononuclear cell blastogenesis . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocyte",
"pos": [
50,
60
]
} | {
"id": "C0024297",
"name": "lymphokines",
"pos": [
276,
287
]
} |
the changes in lymphocyte activity could not be explained by the presence of circulating serum mediators or the biologic effect of soluble mononuclear cell products ( lymphokines ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocyte",
"pos": [
15,
25
]
} | {
"id": "C0024297",
"name": "lymphokines",
"pos": [
167,
178
]
} |
lymphocytes that recognize class i alloantigens ( class i t cells ) are able to lyse appropriate target cells and release lymphokines in vitro . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocytes",
"pos": [
0,
11
]
} | {
"id": "C0024297",
"name": "lymphokines",
"pos": [
122,
133
]
} |
the c-terminal amino acid sequences of preprosomatostatin i and ii were predicted to be identical to mammalian hypothalamic somatostatin-14 ( ss-14 ) and its analog [ tyr7 , gly10 ] ss-14 , respectively . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
111,
123
]
} | {
"id": "C0037659",
"name": "ss-14",
"pos": [
182,
187
]
} |
studies on pooled perfusates from rat hypothalamic tissue show that prepro-ss [ 25-100 ] is released with ss-28 [ 1-12 ] in vitro and accounts for 22 % of the total ss-28 [ 1-12 ] -like immunoreactive material released during depolarization . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
38,
50
]
} | {
"id": "C0037659",
"name": "ss-28",
"pos": [
165,
170
]
} |
these findings indicate that , in spite of a defect to the exocytotic insulin release system , free islet cells displayed a number of properties compatible with a well preserved viability , viz. , the retention of glucose sensitive ( pro ) insulin biosynthesis and metabolism . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "islet",
"pos": [
100,
105
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
240,
247
]
} |
finally , only goblet cells and the mucus blanket lining the intestinal epithelial cells were immunofluorescent when guinea-pig anti- ( highly purified mucin ) serum was used in an indirect immunofluorescence assay . | tissue_is_expression_site_of_gene_product | {
"id": "C0014597",
"name": "epithelial cells",
"pos": [
72,
88
]
} | {
"id": "C0026682",
"name": "mucin",
"pos": [
152,
157
]
} |
the chalone fraction of erythrocyte extracts is immunologically identical to albumin and not identical to hemoglobin . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
24,
35
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
106,
116
]
} |
several lines of evidence indicated that p cell-stimulating factor ( psf ) , a t lymphocyte-derived lymphokine known to stimulate the growth of hemopoietic stem and progenitor cells , also acted on macrophages . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocyte",
"pos": [
81,
91
]
} | {
"id": "C0024297",
"name": "lymphokine",
"pos": [
100,
110
]
} |
the findings revealed that lh-rh is released in detectable amounts from slices prepared from a single hypothalamus , that the amount of lh-rh released is dependent on the stage of the cycle , and that it can be stimulated by known secretagogues like prostaglandin e2 . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
102,
114
]
} | {
"id": "C0023610",
"name": "lh-rh",
"pos": [
136,
141
]
} |
in rat hypophysial portal blood and in hypothalamic extracts from rats and normal mice a single immunoreactive peak was present which corresponded in retention time to synthetic lh-rh . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
39,
51
]
} | {
"id": "C0023610",
"name": "lh-rh",
"pos": [
178,
183
]
} |
the purpose of these studies was to determine whether stimulated human lymphocytes produce lymphokines distinct from ifn gamma , that can activate human blood monocytes to lyse tumor cells . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocytes",
"pos": [
71,
82
]
} | {
"id": "C0024297",
"name": "lymphokines",
"pos": [
91,
102
]
} |
in the anterior pituitary glands of neonatally thyroidectomized female rats sacrificed at 30 days of age , the prolactin granules were small and spherical in shape . | tissue_is_expression_site_of_gene_product | {
"id": "C0032008",
"name": "anterior pituitary glands",
"pos": [
7,
32
]
} | {
"id": "C0033371",
"name": "prolactin",
"pos": [
111,
120
]
} |
finally , anti-t11 antibody could inhibit the srbc enhancing effect on t-lymphocyte function , suggesting that an empty erythrocyte ( e ) receptor on the t lymphocyte was necessary for the srbc action . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t-lymphocyte",
"pos": [
71,
83
]
} | {
"id": "C0034790",
"name": "receptor",
"pos": [
138,
146
]
} |
isolated rat pancreatic islets were incubated in high ( 28 mm ) or low ( 2.8 mm ) glucose for 0 , 1 or 4 hr and insulin biosynthesis and messenger rna quantified . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "pancreatic islets",
"pos": [
13,
30
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
112,
119
]
} |
these data further demonstrate that glucose modulates selectively the level of proinsulin mrna during incubation of isolated pancreatic islets and that changes in the level of proinsulin mrna play an important role in regulation of insulin biosynthesis . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "pancreatic islets",
"pos": [
125,
142
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
232,
239
]
} |
it is suggested that the hypothalamic gr may be involved in the regulation of especially crf secretion but also in the secretion of other anterior pituitary hormones such as trh and somatostatin . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
25,
37
]
} | {
"id": "C0037659",
"name": "somatostatin",
"pos": [
182,
194
]
} |
pituitary rlh and rfsh responses to lhrh stimulation in vivo and in vitro were quantitatively normal or excessive , with delayed peaks suggesting that uremic pituitary gonadotrope secretion is deficient due to lack of appropriate hypothalamic lhrh drive rather than intrinsic pituitary defects . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
230,
242
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
243,
247
]
} |
synthetic rat and ovine crf were tested in an in vitro isolated pancreatic islet system for their ability to influence insulin and glucagon release . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "pancreatic islet",
"pos": [
64,
80
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
119,
126
]
} |
thyroidal thyroxine ( t4 ) , triiodothyronine ( t3 ) , thyroglobulin ( tg ) and t4/t3 ratio were investigated in nodular and paranodular tissue from 16 patients with autonomously functioning thyroid adenomas . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroidal",
"pos": [
0,
9
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
55,
68
]
} |
in all experiments there was no difference between diabetic and control animals in the pituitary luteinizing hormone content , the hypothalamic content of luteinizing hormone-releasing hormone or the ovarian weights . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
131,
143
]
} | {
"id": "C0023610",
"name": "luteinizing hormone-releasing hormone",
"pos": [
155,
192
]
} |
human platelet thrombospondin ( tsp ) was purified to homogeneity by chromatography on fibrinogen coupled to cyanogen bromide-activated sepharose . | tissue_is_expression_site_of_gene_product | {
"id": "C0005821",
"name": "platelet",
"pos": [
6,
14
]
} | {
"id": "C0076560",
"name": "thrombospondin",
"pos": [
15,
29
]
} |
excess fibrinogen ( 30 mg/ml ) added to platelet extract quantitatively inhibited binding of tsp to fibrinogen-sepharose . | tissue_is_expression_site_of_gene_product | {
"id": "C0005821",
"name": "platelet",
"pos": [
40,
48
]
} | {
"id": "C0076560",
"name": "tsp",
"pos": [
93,
96
]
} |
the data show that embryonic mesenchymal cells can produce organized fibers of type iv collagen that are not contained within a basement membrane , and that embryonic epithelial cells deposit fibers and strands of type iv collagen beneath their basal surface when grown on glass ; | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement",
"pos": [
128,
136
]
} | {
"id": "C0009333",
"name": "type",
"pos": [
214,
218
]
} |
mapping of epitopes for monoclonal antibodies against human platelet thrombospondin with electron microscopy and high sensitivity amino acid sequencing . | tissue_is_expression_site_of_gene_product | {
"id": "C0005821",
"name": "platelet",
"pos": [
60,
68
]
} | {
"id": "C0076560",
"name": "thrombospondin",
"pos": [
69,
83
]
} |
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