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lymphocytes from a patient in long term ( greater than 5 yr ) remission exhibited lak against the autologous target e84 , a natural killer ( nk ) -sensitive acute myelomonocytic leukaemia . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocytes",
"pos": [
0,
11
]
} | {
"id": "C0024297",
"name": "lak",
"pos": [
82,
85
]
} |
at the time of maximal lh release induced by e2 + p administration , hypothalamic lhrh was markedly depleted , whereas the larger molecular form was notably augmented . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
69,
81
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
82,
86
]
} |
the data suggest that ovarian steroids not only influence release of hypothalamic lhrh but also the processing of lhrh precursor forms . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
69,
81
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
114,
118
]
} |
short-day ( sd ) exposure also leads to a reduction in hypothalamic norepinephrine ( ne ) and dopamine ( da ) metabolism and an increase in hypothalamic lhrh content which appears to be related to a decrease in lhrh release . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
55,
67
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
211,
215
]
} |
endocrine function of the testes , gonadotropic and lactotropic activity of the adenohypophysis have been studied in elderly men with functional sex disorders and during climacterium virile using a radioimmunoassay to determine the levels of testosterone ( t ) , estradiol ( e2 ) , luteinizing hormone ( lh ) , follicle-stimulating hormone ( fsh ) and prolactin in the peripheral blood plasma . | tissue_is_expression_site_of_gene_product | {
"id": "C0032008",
"name": "adenohypophysis",
"pos": [
80,
95
]
} | {
"id": "C0033371",
"name": "prolactin",
"pos": [
352,
361
]
} |
gnrh is secreted intermittently by the hypothalamus , producing pulsatile lh release , and a pulsatile gnrh stimulus is required to maintain lh secretion . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
39,
51
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
103,
107
]
} |
sephadex g50 chromatography of rat hypothalamic extracts reveals two peaks , detected equally by irma and ria , with a main peak in the elution position of synthetic crf-41 , and a smaller void peak . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
35,
47
]
} | {
"id": "C0010132",
"name": "crf-41",
"pos": [
166,
172
]
} |
results obtained with the t-cell line bk-bi-1.2 , representing insulin-specific t cells with transient il-2r expression , show that the presence of r-il-2 did not prevent a decline in il-2r density occurring on day 5 after antigenic stimulus . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t-cell",
"pos": [
26,
32
]
} | {
"id": "C0034790",
"name": "t cells",
"pos": [
80,
87
]
} |
platelet membrane glycoproteins iib and iiia and platelet thrombospondin were incorporated onto phosphatidylcholine liposomes , by freeze thawing and sonication . | tissue_is_expression_site_of_gene_product | {
"id": "C0005821",
"name": "platelet",
"pos": [
0,
8
]
} | {
"id": "C0076560",
"name": "thrombospondin",
"pos": [
58,
72
]
} |
erythropoiesis-stimulating factor ( s ) , erythropoiesis and erythrocyte 2,3-diphosphoglycerate in young rabbits with marked post-natal fall in haemoglobin . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
61,
72
]
} | {
"id": "C0019046",
"name": "haemoglobin",
"pos": [
144,
155
]
} |
the lack of response to increasing stimulation indicates that the erythropoiesis was restricted by the availability of iron and/or other factors necessary for erythrocyte and haemoglobin production . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
159,
170
]
} | {
"id": "C0019046",
"name": "haemoglobin",
"pos": [
175,
186
]
} |
spleen lymphocytes derived from guinea pigs loose their ability to secrete lymphokines induced by con a after treatment with irradiation ( 500 and 750 mc/kg ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocytes",
"pos": [
7,
18
]
} | {
"id": "C0024297",
"name": "lymphokines",
"pos": [
75,
86
]
} |
in the presence of the immunomodulator isoprinosine , levamisole and the thymosine-like factor tfx the lymphocytes are again capable of secreting lymphokines . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocytes",
"pos": [
103,
114
]
} | {
"id": "C0024297",
"name": "lymphokines",
"pos": [
146,
157
]
} |
serial renal biopsies were examined by light and immunofluorescence microscopy for igg , c3 , neoantigens of the membrane attack complex ( mac ) , and interstitial ( type iii ) and basement membrane ( type iv ) collagen . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membrane",
"pos": [
181,
198
]
} | {
"id": "C0009333",
"name": "type",
"pos": [
201,
205
]
} |
isolated pancreatic islets from the rat secrete insulin in response to glucose or delta-9-tetrahydrocannabinol ( thc ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "pancreatic islets",
"pos": [
9,
26
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
48,
55
]
} |
the stimulatory effects of thc on islet cell aa hydrolysis from phospholipids , lipoxygenase product formation , and secretion suggests that these biochemical sequelae in cell activation are important modulators of insulin release . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "islet cell",
"pos": [
34,
44
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
215,
222
]
} |
alternatively , in the secondary polycythaemias , where oxygen saturation is reduced , the induction of iron deficient red cell changes could be regarded as disadvantageous since at a standard pcv of 0.50 the hb and hence oxygen carrying capacity is reduced by approximately 11 % between mch values of 30 and 20 pg . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cell",
"pos": [
119,
127
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
209,
211
]
} |
differentiation of the epithelium and formation of a bm were examined by electron microscopy , and expression of bm constituents ( type iv collagen , laminin , fibronectin , bullous pemphigoid antigen , and heparan sulfate proteoglycan ) by indirect immunofluorescence . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "bm",
"pos": [
53,
55
]
} | {
"id": "C0009333",
"name": "type iv collagen",
"pos": [
131,
147
]
} |
the fibres containing the two neurohypophysial hormones , originating from separate preoptic perikarya , were intermingled with , and may form endings near all the adenohypophysial cell types except those secreting prolactin . | tissue_is_expression_site_of_gene_product | {
"id": "C0032008",
"name": "adenohypophysial",
"pos": [
164,
180
]
} | {
"id": "C0033371",
"name": "prolactin",
"pos": [
215,
224
]
} |
this suggests that erythroid differentiation might involve coordinate synthesis of erythrocyte proteins subject to regulation by hemin or hemoglobin . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
83,
94
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
138,
148
]
} |
single doses of diethylnitrosamine , n-hydroxy-2-acetylaminofluorene or n-methyl-n-nitrosourea were administered to rats , before or after obstruction of the common bile duct , and liver sections were stained for alpha-fetoprotein , albumin and glucose-6-phosphatase . | tissue_is_expression_site_of_gene_product | {
"id": "C0023884",
"name": "liver",
"pos": [
181,
186
]
} | {
"id": "C0002210",
"name": "alpha-fetoprotein",
"pos": [
213,
230
]
} |
classical pathway deficiencies and low numeric expression of erythrocyte c3b receptors ( cr1 ) are typically associated with autoimmune disorders , while alternative pathway , terminal component , and leukocyte ic3b receptor ( cr3 ) defects predispose to pyogenic bacterial disease . | tissue_is_expression_site_of_gene_product | {
"id": "C0023516",
"name": "leukocyte",
"pos": [
201,
210
]
} | {
"id": "C0079785",
"name": "cr3",
"pos": [
227,
230
]
} |
the effect of fibrosis on drug metabolism in alcoholic liver disease was evaluated in a comparison of the concentrations of serum aminoterminal propeptide of type iii procollagen and basement membrane ( bm ; 7s domain of type iv collagen and laminin ) antigens with in vitro ( cytochrome p-450 ) and in vivo ( antipyrine ) drug metabolism in 67 alcoholics classified by liver histology . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membrane",
"pos": [
183,
200
]
} | {
"id": "C0009333",
"name": "type",
"pos": [
221,
225
]
} |
the role of neuro-transmitters and of hypothalamic releasing and inhibiting factors of growth hormone secretion will be reviewed . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
38,
50
]
} | {
"id": "C0037659",
"name": "inhibiting factors",
"pos": [
65,
83
]
} |
erythrocyte 2 , 3 dpg and met-hb concentrations did not show significant differences between snp-treated and control blood . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
0,
11
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
30,
32
]
} |
although the red cells and the haemoglobin are involved in the metabolism of snp , in clinical doses snp does not alter the oxygen affinity . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red",
"pos": [
13,
16
]
} | {
"id": "C0019046",
"name": "haemoglobin",
"pos": [
31,
42
]
} |
in isolated pancreatic islets , pyruvate causes a shift to the left of the sigmoidal curve relating the rate of insulin release to the ambient glucose concentration . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "pancreatic islets",
"pos": [
12,
29
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
112,
119
]
} |
similar reductions in rbc ca activity were found in his father -- 2.0 and 2.1 u/g hb compared with 3.3 and 3.9 u/g hb in adult controls . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "rbc",
"pos": [
22,
25
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
115,
117
]
} |
preparations of human leukocyte ( alpha ) and fibroblast ( beta ) interferon were given intramuscularly to rabbits and monkeys , and circulating interferon was measured . | tissue_is_expression_site_of_gene_product | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
46,
56
]
} | {
"id": "C0015980",
"name": "beta",
"pos": [
59,
63
]
} |
these patterns indicate that human amniotic interferon is similar to human fibroblast ( beta ) interferon but different from human leukocyte ( alpha ) interferon . | tissue_is_expression_site_of_gene_product | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
75,
85
]
} | {
"id": "C0015980",
"name": "beta",
"pos": [
88,
92
]
} |
mammals display a wide range in whole blood oxygen affinity dependent on three major factors : the intrinsic oxygen affinity of the hemoglobin , the level of red cell 2,3-dpg , and the response of the hemoglobin to 2,3-dpg . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cell",
"pos": [
158,
166
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
201,
211
]
} |
anterior pituitary glands from normal untreated rats synthesize and release the hormone prolactin ( prl ) during incubation under in vitro conditions . | tissue_is_expression_site_of_gene_product | {
"id": "C0032008",
"name": "anterior pituitary glands",
"pos": [
0,
25
]
} | {
"id": "C0033371",
"name": "prolactin",
"pos": [
88,
97
]
} |
the present work demonstrates that it is not the iodine content per se but , rather , tsh-regulated thyroid activity which modulates the substructure of thyroglobulin . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
100,
107
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
153,
166
]
} |
after 24 h of culture in medium containing heat-inactivated fetal calf serum , hypothalamic fragments were incubated in serum-free medium , and the release of immunoreactive srif was quantitated . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
79,
91
]
} | {
"id": "C0037659",
"name": "srif",
"pos": [
174,
178
]
} |
finally , when hypothalami were incubated with melatonin and serotonin , each at 10 ( -- 7 ) m , srif release was unchanged compared to control values . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalami",
"pos": [
15,
26
]
} | {
"id": "C0037659",
"name": "srif",
"pos": [
97,
101
]
} |
insulin secretion , biosynthesis and content of isolated pancreatic islets prepared for fetuses of nondiabetic or insulin-dependent diabetic women were investigated in vitro . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "pancreatic islets",
"pos": [
57,
74
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
114,
121
]
} |
to assess the functional capability of human milk lymphocytes , we studied phytohemagglutinin-induced lymphokine production by breast milk and , for comparison , peripheral blood lymphocyte cultures . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocytes",
"pos": [
50,
61
]
} | {
"id": "C0024297",
"name": "lymphokine",
"pos": [
102,
112
]
} |
induction both in vivo and in vitro leads to a loss of these proteins and to the appearance of basement membrane components including type iv collagen . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membrane",
"pos": [
95,
112
]
} | {
"id": "C0009333",
"name": "type iv collagen",
"pos": [
134,
150
]
} |
fractions of thyroid homogenates were obtained by differential centrifugation , and the maximal inhibitory influence of tg was located in the 5000 x g fraction . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
13,
20
]
} | {
"id": "C0040123",
"name": "tg",
"pos": [
120,
122
]
} |
during short-term incubation studies both placenta and fetal kidney were found to synthesize and secrete the beta-subunit of chorionic gonadotropin , whereas its synthesis was not observed in fetal liver , lung or muscle . | tissue_is_expression_site_of_gene_product | {
"id": "C0032043",
"name": "placenta",
"pos": [
42,
50
]
} | {
"id": "C0106132",
"name": "beta-subunit",
"pos": [
109,
121
]
} |
generally , rbc , wbc and pcv were found to be increased while ct , esr , hb , mch , mchc and mcv were decreased . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "rbc",
"pos": [
12,
15
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
74,
76
]
} |
these observations suggest that immunoreactive material in pineal gland may be an lhrh-like substance whose affinity characteristics are different from that of hypothalamic lhrh . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
160,
172
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
173,
177
]
} |
these experiments demonstrate the production of a human lymphocyte factor ( lymphokine ) that induces lp synthesis . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocyte",
"pos": [
56,
66
]
} | {
"id": "C0024297",
"name": "lymphokine",
"pos": [
76,
86
]
} |
the morphology of the thyroid lesions and the presence of circulating thyroglobulin autoantibodies suggested that lymphocytic thyroiditis was immune-mediated . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
22,
29
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
70,
83
]
} |
cultivation of pancreatic islets of sand rats in the presence of high glucose led to a very high insulin release and to strongly diminished insulin contents independent of the metabolic stage of the sand rats . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "pancreatic islets",
"pos": [
15,
32
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
140,
147
]
} |
isolated rat pancreatic islet extracts were submitted to reverse phase high pressure chromatography ( hplc ) and assayed for thyrotrophin releasing factor ( trf ) , glucagon and insulin in radioimmunoassays ( ria ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "pancreatic islet",
"pos": [
13,
29
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
178,
185
]
} |
rate constants determined for o2 binding in rbc were intermediate between rates observed for reaction with fast ans slow reacting forms of hb and probably consist of contributions from each . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "rbc",
"pos": [
44,
47
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
139,
141
]
} |
in mice with an earlier serum alpha-fp elevation ( cba , c3h/hej and dd ) , the liver hemopoiesis also started earlier than in those with a delayed alpha-fp maximum ( c57bl/6 and cc57br/mv ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0023884",
"name": "liver",
"pos": [
80,
85
]
} | {
"id": "C0002210",
"name": "alpha-fp",
"pos": [
148,
156
]
} |
the present morphological results support the hypothesis that enkephalins may exert their gh-releasing effect at the hypothalamic level and suggest that enkephalins might directly modulate the somatostatin release into the blood of the portal plexus . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
117,
129
]
} | {
"id": "C0037659",
"name": "somatostatin",
"pos": [
193,
205
]
} |
noradrenaline ( na ) was not effective on mbh slices , but elicited a dose-dependent stimulation of srif release from poa and amy ( ed50 = 6.4 +/- 1.4 nm and 3.6 +/- 1.2 nm respectively ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "mbh",
"pos": [
42,
45
]
} | {
"id": "C0037659",
"name": "srif",
"pos": [
100,
104
]
} |
effects of growth hormone excess and deficiency on hypothalamic somatostatin content and release and on tissue somatostatin distribution . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
51,
63
]
} | {
"id": "C0037659",
"name": "somatostatin",
"pos": [
111,
123
]
} |
considerable indirect evidence now exists to suggest that hypothalamic somatostatin ( srif ) is the physiological inhibitory regulator of pituitary gh release . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
58,
70
]
} | {
"id": "C0037659",
"name": "srif",
"pos": [
86,
90
]
} |
to support this relationship further , we studied the effect of in vivo modifications of gh homeostasis on hypothalamic srif content and in vitro release in an attempt to document a feedback relationship between the two peptides . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
107,
119
]
} | {
"id": "C0037659",
"name": "srif",
"pos": [
120,
124
]
} |
exposure of isolated rat pancreatic islets to 1 mm 3-isobutyl-1-methyl-xanthine ( ibmx ) resulted in a 5.7-fold increase in the rate of insulin release . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "pancreatic islets",
"pos": [
25,
42
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
136,
143
]
} |
lymphocyte supernatant ( ls ) containing lymphokine ( lk ) activated rat peritoneal macrophages ( pm ) and at the same time enhanced their fc receptor ( fcr ) activity . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocyte",
"pos": [
0,
10
]
} | {
"id": "C0024297",
"name": "lymphokine",
"pos": [
41,
51
]
} |
the results emphasize the presence of erythrocyte and serum factors other than hemoglobin which stimulate the growth of r. quintana . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
38,
49
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
79,
89
]
} |
isolated rat islets of langerhans were incubated for 60 , 120 , and 180 min and the incorporation of leucine- ( 3 ) h into proinsulin and insulin moieties was followed . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "islets of langerhans",
"pos": [
13,
33
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
138,
145
]
} |
[ a case of hypothyroidism caused by abnormality of hormogenesis : presence in the thyroid of an abnormal thyroglobulin ] . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
16,
23
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
106,
119
]
} |
lymphocytes , stimulated with concanavalin a , release small amounts of non-immunoglobulin , highly reactive proteins called lymphokines . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocytes",
"pos": [
0,
11
]
} | {
"id": "C0024297",
"name": "lymphokines",
"pos": [
125,
136
]
} |
after a review of the significance of the releasing and inhibiting polypeptide hormones of the hypothalamus , the clinical significance of the gonadotropin-releasing-hormone and the thyrotropin releasing hormone , is discussed in detail . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
95,
107
]
} | {
"id": "C0023610",
"name": "gonadotropin-releasing-hormone",
"pos": [
143,
173
]
} |
four instruments for the determination of rbc , hb and pcv , with different degree of automation , have been compared in strictly routinary working conditions . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "rbc",
"pos": [
42,
45
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
48,
50
]
} |
as far as acuracy is regarded , collaborative experiments showed general agreement with the ( provisional ) reference values , with occasional occurrence of typical systematic errors in rbc and hb determinations . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "rbc",
"pos": [
186,
189
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
194,
196
]
} |
plasma membranes prepared from human thyroid tissue have specific binding sites for human tg , as shown by [ 125i ] tg binding assay . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
37,
44
]
} | {
"id": "C0040123",
"name": "tg",
"pos": [
116,
118
]
} |
it is assumed that proteins released by lymphocytes without mitogenic activation in vitro are involved in the mediation of lymphocyte interactions and may be related to lymphokines synthesized and released by activated cells . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocyte",
"pos": [
40,
50
]
} | {
"id": "C0024297",
"name": "lymphokines",
"pos": [
169,
180
]
} |
effects of estrogen on 3h-leucine uptake by the hypothalamus and pituitary : correlation with hypothalamic and serum lhrh and lh . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
94,
106
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
117,
121
]
} |
blood ph , pco2 , concentration of 2,3-dpg , lactic acid , pyruvic acid , red blood cell , hemoglobin and hematocrit were also determined , the related parameters have been calculated . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red blood cell",
"pos": [
74,
88
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
91,
101
]
} |
the results show that the coefficient of variation of the hemoglobin concentration is relatively small ( about 5.5 per cent ) in the case of fresh human red cells in acd solution , that the coefficient of variation is almost doubled when the red cells have been stored for 6 weeks at 4 degrees c. or when heparin is used as an anticoagulant instead of acd solution , but that the average hemoglobin concentration is substantially the same in all three cases . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cells",
"pos": [
153,
162
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
388,
398
]
} |
in t cells , initial activation from g0 to g1 results from stimulation of either the antigen/major histocompatibility complex receptor ( t3-ti ) or the t11 structure ; | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
3,
10
]
} | {
"id": "C0034790",
"name": "major",
"pos": [
93,
98
]
} |
previous studies have shown that the purified t lymphocyte glycoprotein , cluster differentiation 2 ( cd2 ) ( also known as t11 , lymphocyte function-associated antigen ( lfa ) -2 , and the erythrocyte ( e ) rosette receptor ) interacts with the lfa-3 molecule on human e . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t lymphocyte",
"pos": [
46,
58
]
} | {
"id": "C0108773",
"name": "e",
"pos": [
270,
271
]
} |
the result indicates that thyroglobulin ( tg ) exists in two forms in crude tmag , i.e. , 'free tg ' and 'membrane-bound tg ' . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "tmag",
"pos": [
76,
80
]
} | {
"id": "C0040123",
"name": "tg",
"pos": [
121,
123
]
} |
we have isolated the cdna for human lymphocyte function-associated antigen 3 ( lfa-3 ) , the ligand of the t lymphocyte cd2 molecule . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t lymphocyte",
"pos": [
107,
119
]
} | {
"id": "C0108773",
"name": "cd2 molecule",
"pos": [
120,
132
]
} |
the release of crf into the hypothalamic-hypophyseal portal system in response to stress is known , and it has been suggested that crf may function elsewhere in the central nervous system to promote stress-induced physiological and behavioral changes . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
28,
40
]
} | {
"id": "C0010132",
"name": "crf",
"pos": [
131,
134
]
} |
pulsatile hypothalamic ( lhrh- ) activity occurs early in childhood and shows a specific development after the onset of puberty , resulting in progressive enhancement of gonadal estrogen and gestagen secretion finally until the menstrual cycle is established by specially characterized hormonal controls . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
10,
22
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
25,
29
]
} |
the addition of npy ( final concentrations of 10 ( -8 ) to 10 ( -11 ) m ) or the structurally similar neuropeptide , rat pancreatic polypeptide , to culture medium containing hemi-apg did not alter the release of lh , fsh , or tsh . | tissue_is_expression_site_of_gene_product | {
"id": "C0032008",
"name": "apg",
"pos": [
180,
183
]
} | {
"id": "C0040160",
"name": "tsh",
"pos": [
227,
230
]
} |
infusion of il-1 induced a significant secretion of crf into the circulation exiting the hypothalamus , whereas immunoneutralization of crf blocked the stimulatory effect of il-1 on glucocorticoid secretion . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
89,
101
]
} | {
"id": "C0010132",
"name": "crf",
"pos": [
136,
139
]
} |
second , after blockade of fast axonal transport in hypothalamic neurons by colchicine , il-1 administration decreased the crf immunostaining in the median eminence , indicating an enhanced release of crf in response to il-1 . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
52,
64
]
} | {
"id": "C0010132",
"name": "crf",
"pos": [
201,
204
]
} |
iron status , including hemoglobin , s-ferritin , s-iron , s-transferrin , transferrin saturation and the erythrocyte zinc protoporphyrin/hemoglobin ( zpp : hb ) ratio , was evaluated in 85 healthy iron-supplemented mothers at parturition and in 74 of their term newborn infants . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
106,
117
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
157,
159
]
} |
studies on three serial sections of 88 thyroid glands stained with hematoxylin and eosin , thyroglobulin ( tg ) , and thyroxin ( t4 ) , respectively , revealed the followings : ( i ) tg/t4 staining is dependent on the follicle structure ( i.e. , f or p ) ; | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid glands",
"pos": [
39,
53
]
} | {
"id": "C0040123",
"name": "tg",
"pos": [
183,
185
]
} |
although the lumenal contents of the cysts in parathyroid iii revealed no immunoreactivity for 19s-thyroglobulin , those in thyroid parenchyma , c-cell complexes , parathyroid iv , and thymus iv reacted strongly with the 19s-thyroglobulin antiserum . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
50,
57
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
225,
238
]
} |
a simple and rapid method of 2d agarose gel ( ph 5.4 ) -horizontal polyacrylamide gel ( ph 9.0 ) electrophoresis was developed for the simultaneous phenotyping of pig plasma alpha-protease inhibitors ( protease inhibitor-1 and -2 ; postalbumin-1a and -1b ) , postalbumin-2 , transferrin , ceruloplasmin and haemopexin . | tissue_is_expression_site_of_gene_product | {
"id": "C0032105",
"name": "plasma",
"pos": [
167,
173
]
} | {
"id": "C0019067",
"name": "haemopexin",
"pos": [
307,
317
]
} |
lymphocyte phenotype , lymphokine levels or production , and haematopoietic progenitor cell number were measured 3 months after therapy ; | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocyte",
"pos": [
0,
10
]
} | {
"id": "C0024297",
"name": "lymphokine",
"pos": [
23,
33
]
} |
less consistent were positive correlations between hba2 and rbc , between hbf and both mcv and haemoglobin , between mchc and mcv , and a negative relationship between haemoglobin and reticulocyte count . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "rbc",
"pos": [
60,
63
]
} | {
"id": "C0019046",
"name": "haemoglobin",
"pos": [
168,
179
]
} |
to clarify the relationship of lgl/nk cells to t cells we studied patterns of rearrangement and expression of the t cell receptor ( ti ) genes alpha , beta , and gamma in normal human lgls ; | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
47,
54
]
} | {
"id": "C0034790",
"name": "t cell receptor",
"pos": [
114,
129
]
} |
these results indicate that the normal lgl/nk population is homogeneous and distinct from the normal t cell population because it does not express , and as a result , can not effect its immune function through the t cell receptor molecules . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cell",
"pos": [
101,
107
]
} | {
"id": "C0034790",
"name": "t cell receptor",
"pos": [
214,
229
]
} |
these findings suggest that , in tumor as in normal islet cells , the regulation of insulin release by exogenous nutrients depends on the availability of endogenous atp . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "islet cells",
"pos": [
52,
63
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
84,
91
]
} |
the distribution of basement membrane and extracellular matrix components laminin , fibronectin , type iv collagen and heparan sulphate proteoglycan was examined during posterior neuropore closure and secondary neurulation in the mouse embryo . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membrane",
"pos": [
20,
37
]
} | {
"id": "C0009333",
"name": "type iv collagen",
"pos": [
98,
114
]
} |
in regions of neural crest migration , the deposition of basement membrane components was altered , lacking laminin and type iv collagen , with increased deposition of fibronectin and heparan sulphate proteoglycan . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membrane",
"pos": [
57,
74
]
} | {
"id": "C0009333",
"name": "type",
"pos": [
120,
124
]
} |
we find that the susceptibility of ec thrombospondin to proteolysis is five-fold smaller than that of platelet thrombospondin . | tissue_is_expression_site_of_gene_product | {
"id": "C0005821",
"name": "platelet",
"pos": [
102,
110
]
} | {
"id": "C0076560",
"name": "thrombospondin",
"pos": [
111,
125
]
} |
trypsin digestion for 5 min at room temperature at an enzyme-to-substrate ratio of 1:20 produces a stable fragment of 140 kda but not the 30-kda fragment observed in platelet thrombospondin . | tissue_is_expression_site_of_gene_product | {
"id": "C0005821",
"name": "platelet",
"pos": [
166,
174
]
} | {
"id": "C0076560",
"name": "thrombospondin",
"pos": [
175,
189
]
} |
chymotrypsin , under identical conditions to those used for trypsin , cleaves ec thrombospondin into four stable fragments of 160 kda , 140 kda , 27 kda and 18 kda . | tissue_is_expression_site_of_gene_product | {
"id": "C0225336",
"name": "ec",
"pos": [
78,
80
]
} | {
"id": "C0076560",
"name": "thrombospondin",
"pos": [
81,
95
]
} |
under the conditions used a cryptic thrombin-cleavage site , not hitherto observed in platelet thrombospondin , was observed in ec thrombospondin . | tissue_is_expression_site_of_gene_product | {
"id": "C0005821",
"name": "platelet",
"pos": [
86,
94
]
} | {
"id": "C0076560",
"name": "thrombospondin",
"pos": [
131,
145
]
} |
under the conditions used a cryptic thrombin-cleavage site , not hitherto observed in platelet thrombospondin , was observed in ec thrombospondin . | tissue_is_expression_site_of_gene_product | {
"id": "C0225336",
"name": "ec",
"pos": [
128,
130
]
} | {
"id": "C0076560",
"name": "thrombospondin",
"pos": [
131,
145
]
} |
two-dimensional gel electrophoresis of the chymotryptic heparin-binding fragments shows that each molecule gave rise to a heterogeneous array of fragments of high molecular mass bound by disulfide bonds , indicating that there is a difference in the rate of cleavage between the three subunits of ec thrombospondin . | tissue_is_expression_site_of_gene_product | {
"id": "C0225336",
"name": "ec",
"pos": [
22,
24
]
} | {
"id": "C0076560",
"name": "thrombospondin",
"pos": [
300,
314
]
} |
trypsin , despite its limited degradation , completely eliminated the heparin-binding capacity of both high and low-affinity loci , in contrast to platelet thrombospondin where the high affinity remains intact . | tissue_is_expression_site_of_gene_product | {
"id": "C0005821",
"name": "platelet",
"pos": [
147,
155
]
} | {
"id": "C0076560",
"name": "thrombospondin",
"pos": [
156,
170
]
} |
in 36 cytoplasmic islet cell antibody ( ica ) -positive nondiabetic first-degree relatives of type i ( insulin-dependent ) patients less than 30 yr of age , ciaa levels exceeded the normal range in 20 ( 55.6 % ) of 36 ( mean 86.8 +/- 17.1 nu/ml ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "islet cell",
"pos": [
18,
28
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
103,
110
]
} |
the elevated blood lead level , increased urinary delta-amino-levulinic acid ( ala-u ) excretion , depletion in rbc and haemoglobin content and more number of reticulocytes in peripheral blood indicated the increased intensity of lead toxicity and inhibitory effect on haem biosynthesis . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "rbc",
"pos": [
112,
115
]
} | {
"id": "C0019046",
"name": "haemoglobin",
"pos": [
120,
131
]
} |
while our results do not exclude thrombospondin as a mediator of cytoadherence to endothelial cells in vivo , they showed no correlation between the presence of thrombospondin and the ability of melanoma cell lines to cytoadhere in vitro . | tissue_is_expression_site_of_gene_product | {
"id": "C0225336",
"name": "endothelial cells",
"pos": [
82,
99
]
} | {
"id": "C0076560",
"name": "thrombospondin",
"pos": [
161,
175
]
} |
we studied binding and degradation of labeled platelet thrombospondin ( tsp ) by normal and variant bovine aorta endothelial ( bae ) cells . | tissue_is_expression_site_of_gene_product | {
"id": "C0005821",
"name": "platelet",
"pos": [
46,
54
]
} | {
"id": "C0076560",
"name": "thrombospondin",
"pos": [
55,
69
]
} |
those basement membranes that lacked the hspg strongly stained with antisera against laminin and type iv collagen . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membranes",
"pos": [
6,
24
]
} | {
"id": "C0009333",
"name": "type iv collagen",
"pos": [
97,
113
]
} |
in the thyroid glands , thyroglobulin ( tg ) is specifically synthesized by follicular cells and then secreted into the apical lumen where it is concentrated and used as a substrate for thyroid hormone synthesis . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid glands",
"pos": [
7,
21
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
24,
37
]
} |
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