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stringlengths 57
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dict |
|---|---|---|---|
the capability of involved epidermal cells to activate cd4+ t lymphocytes was dependent upon cd1+dr+ leukocytes and not dr+ keratinocytes , because depletion of either hla-dr+ , cd1+ or hle1+ epidermal cells totally abrogated the t-lymphocyte proliferation . | tissue_is_expression_site_of_gene_product | {
"id": "C0039215",
"name": "cd4",
"pos": [
55,
58
]
} | {
"id": "C0019764",
"name": "hla-dr",
"pos": [
168,
174
]
} |
it is known that in adult rats , gh by itself and by promoting secretion of the somatomedins acts at the level of the hypothalamus to trigger release of somatostatin and decrease output of gh-releasing hormone ( ghrh ) , thereby inhibiting further secretion of gh . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
118,
130
]
} | {
"id": "C0037659",
"name": "somatostatin",
"pos": [
153,
165
]
} |
it is known that in adult rats , gh by itself and by promoting secretion of the somatomedins acts at the level of the hypothalamus to trigger release of somatostatin and decrease output of gh-releasing hormone ( ghrh ) , thereby inhibiting further secretion of gh . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
118,
130
]
} | {
"id": "C0037668",
"name": "gh-releasing hormone",
"pos": [
189,
209
]
} |
however , concomitant involvement of hypothalamic somatostatin as a result of gh treatment can not be ruled out . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
37,
49
]
} | {
"id": "C0037659",
"name": "somatostatin",
"pos": [
50,
62
]
} |
the aim of the present study was to examine the temporal changes in hypothalamic lhrh content and gonadotrophin secretion during restraint stress , and the pituitary responsiveness to lhrh stimulation in chronically stressed rats . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
68,
80
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
184,
188
]
} |
after 20-45 min of stress there was an increase in plasma concentrations of lh ( p less than 0.01 ) and a decrease in hypothalamic lhrh content ( p less than 0.01 ) , suggesting a negative correlation between plasma lh and hypothalamic lhrh concentrations . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
118,
130
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
236,
240
]
} |
red cell count ( rbc ) , hemoglobin ( hb ) , packed cell volume ( pcv ) and mean corpuscular volume ( mcv ) were significantly higher and mean corpuscular hemoglobin concentration ( mchc ) was lower in excited deer than in resting deer . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "rbc",
"pos": [
17,
20
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
155,
165
]
} |
as indirect indicators of basement membrane biosynthesis , we have measured , by filter hybridization with labeled cdna probes , the relative abundance of mrnas for laminin and collagen iv chains in enterocyte fractions representing the crypt-villus gradient of differentiation and in cells of the underlying lamina propria . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membrane",
"pos": [
26,
43
]
} | {
"id": "C0009333",
"name": "collagen iv",
"pos": [
177,
188
]
} |
in the absence of pathological changes in the thyroid an increase in the level of thyroglobulin can be regarded as a tumor marker of metastatic growth of papillary and papillary-follicular cancer . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
46,
53
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
82,
95
]
} |
in order to evaluate the effects of environmental lighting on the hypothalamic secretion of luteinizing hormone-releasing hormone ( lhrh ) , intact and castrated male wistar rats were kept either in periodic ( ld ) or in constant light ( ll ) for 1 week , and the hypothalamic lhrh concentration was measured by radioimmunoassay . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
66,
78
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
277,
281
]
} |
in intact or castrated rats the melatonin injections were not able to prevent the change of hypothalamic lhrh in constant light . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
92,
104
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
105,
109
]
} |
the present results suggest that constant light reduces the synthesis of hypothalamic lhrh in intact rats but increases it in castrated rats . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
73,
85
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
86,
90
]
} |
a possible role for this enzyme in basement membrane type iv collagen turnover has also been suggested . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membrane",
"pos": [
35,
52
]
} | {
"id": "C0009333",
"name": "type iv collagen",
"pos": [
53,
69
]
} |
in order to investigate the relative roles of hypothalamic crf-41 and vasopressin as mediators of the stimulant effects of alpha 1-adrenoceptors on acth secretion , we examined the effects of equipotent doses of antagonists to crf-41 and vasopressin on the acth responses to methoxamine . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
46,
58
]
} | {
"id": "C0010132",
"name": "crf-41",
"pos": [
227,
233
]
} |
interleukin-1 inhibits the ovarian steroid-induced luteinizing hormone surge and release of hypothalamic luteinizing hormone-releasing hormone in rats . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
92,
104
]
} | {
"id": "C0023610",
"name": "luteinizing hormone-releasing hormone",
"pos": [
105,
142
]
} |
we have examined the effects of human recombinant il-1 ( alpha- and beta-subtypes ) on lh release in vivo and hypothalamic lhrh release in vitro . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
110,
122
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
123,
127
]
} |
the absence of cd8+ peripheral t cells in these mice suggests that these iel differ from classical t cells in their ability to differentiate and express cd8 and do not require t cell receptor expression for their localization to the intestine . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
31,
38
]
} | {
"id": "C0034790",
"name": "t cell receptor",
"pos": [
176,
191
]
} |
we have identified a mr 80k cell surface protein ( s ) from adult rat hepatocytes that binds basement membrane components , including collagen iv , heparan sulfate proteoglycan , and laminin . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membrane",
"pos": [
93,
110
]
} | {
"id": "C0009333",
"name": "collagen iv",
"pos": [
134,
145
]
} |
a large heparan sulfate proteoglycan , important for charge-dependent molecular sieving , is firmly anchored in the basement membrane and can bind itself through a core-protein interaction to form dimers and oligomers and bind laminin and type iv collagen through its glycosaminoglycan chains . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membrane",
"pos": [
116,
133
]
} | {
"id": "C0009333",
"name": "type iv collagen",
"pos": [
239,
255
]
} |
although thyroid diseases causing elevated tg levels are rare in forensic cases , they should be excluded by routine histology of the thyroid at autopsy , so that the finding of a high tg level would thus carry more weight when given in evidence . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
9,
16
]
} | {
"id": "C0040123",
"name": "tg",
"pos": [
185,
187
]
} |
this model allowed us to test a second hypothesis , that b-fsh is a sensitive indicator of hypothalamic gnrh release . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
91,
103
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
104,
108
]
} |
because lymphocytes from both young and old nzb mice showed diminished igg1 and igg2a secretion after lymphokine treatment , b cells from this strain appeared to be intrinsically resistant to the effects of il-4 and ifn-gamma . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocytes",
"pos": [
8,
19
]
} | {
"id": "C0024297",
"name": "lymphokine",
"pos": [
102,
112
]
} |
by morphometric analysis , a marked reduction in the mca lumen cross-sectional area was observed after selective application of rbc 's or hb/cytosol but not of wbc/prp or erythrocyte membranes . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "rbc 's",
"pos": [
128,
134
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
138,
140
]
} |
in both rbc- and hb/cytosol-treated vessels , luminal narrowing was associated with a differential increase in vessel wall thickness of the ventral ( subarachnoid ) compared to the dorsal ( brain ) aspect of the artery , but no significant change in cross-sectional area of the vessel wall . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "rbc",
"pos": [
8,
11
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
17,
19
]
} |
after 10 days of exposure to rbc 's or hb/cytosol , there was a spectrum of ultrastructural changes in the vessel wall comparable to those seen after periadventitial application of whole blood . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "rbc 's",
"pos": [
29,
35
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
39,
41
]
} |
recombinant dna and the liver : studies with albumin , alpha-fetoprotein , hepatitis b virus , and other dna probes . | tissue_is_expression_site_of_gene_product | {
"id": "C0023884",
"name": "liver",
"pos": [
24,
29
]
} | {
"id": "C0002210",
"name": "alpha-fetoprotein",
"pos": [
55,
72
]
} |
animals with this naturally occurring malarial infection are anemic : immature erythrocytes in peripheral blood become abundant ( 1 to 30 percent ) , and blood hemoglobin concentration decreases 25 percent . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocytes",
"pos": [
79,
91
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
160,
170
]
} |
in a region of endemic goitres , 200 untreated patients in whom thyroid microsomal ( mcha ) and/or thyroglobulin ( tgha ) antibodies have been detected were analyzed and other organ specific autoantibodies were tested . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
64,
71
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
99,
112
]
} |
since the fractional growth rate of the muscle was decreased or unchanged , t3 treatment increased the rate of muscle protein breakdown . | tissue_is_expression_site_of_gene_product | {
"id": "C0026845",
"name": "muscle",
"pos": [
40,
46
]
} | {
"id": "C0026832",
"name": "muscle protein",
"pos": [
111,
125
]
} |
in red cells containing oxy- or carbonmono-oxy-haemoglobin , hexose monophosphate-shunt activity was mainly responsible for metabolism of t-butyl hydroperoxide ; | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cells",
"pos": [
3,
12
]
} | {
"id": "C0030069",
"name": "oxy-haemoglobin",
"pos": [
43,
58
]
} |
these studies suggested that the drug acts primarily on the hypothalamus to suppress luteinizing hormone releasing hormone ( lhrh ) secretion . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
60,
72
]
} | {
"id": "C0023610",
"name": "luteinizing hormone releasing hormone",
"pos": [
85,
122
]
} |
[ effect of donor splenic lymphocytes treated with carbon tetrachloride on liver mitotic activity and alpha-fetoprotein production in syngeneic recipients ] . | tissue_is_expression_site_of_gene_product | {
"id": "C0023884",
"name": "liver",
"pos": [
75,
80
]
} | {
"id": "C0002210",
"name": "alpha-fetoprotein",
"pos": [
102,
119
]
} |
the results indicate that two kinds of somatostatin neuronal systems exist in rat hypothalamus : one is involved in the production of hormonal somatostatin and the other serves for the regulation of neuronal activities in restricted hypothalamic nuclei . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
82,
94
]
} | {
"id": "C0037659",
"name": "somatostatin",
"pos": [
143,
155
]
} |
aggregates of basal cell carcinoma in the dermis were surrounded by a continuous basement membrane containing laminin and type iv collagen ; | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membrane",
"pos": [
81,
98
]
} | {
"id": "C0009333",
"name": "type iv collagen",
"pos": [
122,
138
]
} |
frontal deafferentation of the mediobasal hypothalamus in the neonatal rat and its effects on the preoptico-infundibular lhrh-tract . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
42,
54
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
121,
125
]
} |
in the latter group , however , marked reduction in the number of the lhrh-nerve fibers was observed behind the sites of the deafferentation in the mediobasal hypothalamus ( mbh ) , whereas lhrh-immunoreactive perikarya and nerve fibers containing the immunoreactive material were seen rostral to the plane of severance . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
159,
171
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
190,
194
]
} |
twenty colonic adenocarcinomas were studied by immunofluorescence with antisera against components of the basement membrane : type iv collagen , laminin and heparan sulfate-rich proteoglycan , as well as antisera against antigens of the connective tissue : type-iii collagen , fibronectin and hyaluronectin . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membrane",
"pos": [
106,
123
]
} | {
"id": "C0009333",
"name": "type iv collagen",
"pos": [
126,
142
]
} |
in contrast to human fibroblast cells , in which the synthesis of induced beta-interferon is transient , the poly ( ri . rc ) -induced tk+ lines continued to produce beta-interferon for prolonged periods of time and did not respond to superinduction conditions . | tissue_is_expression_site_of_gene_product | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
21,
31
]
} | {
"id": "C0015980",
"name": "beta-interferon",
"pos": [
166,
181
]
} |
a lysed crude secretory granule fraction from rat islets of langerhans was shown to process endogenous proinsulin to insulin with a ph optimum of 5.0 -- 6.0 . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "islets of langerhans",
"pos": [
50,
70
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
117,
124
]
} |
the behavior of the oxyhemoglobin curve was studied in ten patients with respiratory alkalosis ( arterial [ h+ ] less than 37 nm , pco2 less than 32 mmhg and hco-3 less than 22.0 meq/l ) and ten patients with metabolic alkalosis ( [ h+ ] less than 34 nm , pco2 greater than 37 mmhg and hco-3 greater than 28.0 meq/l ) to determine whether different alkalotic states similarly affect the red blood cell [ h+ ] and 2,3-diphosphoglycerate interaction and thus the oxygen affinity of hemoglobin . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red blood cell",
"pos": [
387,
401
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
480,
490
]
} |
these results suggest that endotoxin is a potent stimulus for hypothalamic somatostatin release in the rat . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
62,
74
]
} | {
"id": "C0037659",
"name": "somatostatin",
"pos": [
75,
87
]
} |
the activated protein c formed in the plasma is immunoadsorbed with goat anti-human protein c igg-agarose . | tissue_is_expression_site_of_gene_product | {
"id": "C0032105",
"name": "plasma",
"pos": [
38,
44
]
} | {
"id": "C1949480",
"name": "human",
"pos": [
78,
83
]
} |
the unlabeled antibody peroxidase-antiperoxidase technique was used to examine human malignant prostatic tissue ( primary tumors ) for the presence of prostate-specific antigen ( psa ) , carcinoembryonic antigen ( cea ) , nonspecific cross-reacting antigen ( nca ) , and beta-chorionic gonadotrophin ( hcg ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0033572",
"name": "prostatic",
"pos": [
95,
104
]
} | {
"id": "C0138741",
"name": "prostate-specific antigen",
"pos": [
151,
176
]
} |
the cell yield in this fraction , from each preneoplastic liver , was 5.7 x 10 ( 7 ) cells , 93 +/- 2 % of which were gamma-glutamyl transpeptidase positive , 6 +/- 1 % peroxidase positive , 61 % albumin positive , and 29 % alpha-fetoprotein positive . | tissue_is_expression_site_of_gene_product | {
"id": "C0023884",
"name": "liver",
"pos": [
58,
63
]
} | {
"id": "C0002210",
"name": "alpha-fetoprotein",
"pos": [
224,
241
]
} |
these observations led to the following conclusions : 1 ) crf-li is an important hypothalamic regulator of adenohypophysial acth secretion , 2 ) crf-li in the hypophysial portal circulation is derived from crf-li-containing neurons within the paraventricular nuclei , and 3 ) glucocorticoid negative feedback effects can be exerted at the central level . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
81,
93
]
} | {
"id": "C0010132",
"name": "crf-li",
"pos": [
206,
212
]
} |
at stages xx-xxi , adult type rbcs ( containing adult hemoglobins ) accounted for 22 % of the rbc population . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "rbcs",
"pos": [
30,
34
]
} | {
"id": "C0019046",
"name": "hemoglobins",
"pos": [
54,
65
]
} |
these studies show that in vitro , the lhrh output of the poa-mbh from the eb- or ebp-treated rats varies significantly during the day and that the poa-mbh of eb-treated rats secretes large amounts of lhrh in vitro , which correlate well with the afternoon lh rise . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "poa-mbh",
"pos": [
58,
65
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
201,
205
]
} |
in addition , treatment with p in vivo changes the in vitro pattern of lhrh output from the poa-mbh of these eb-primed rats , whereas superfusion of p in vitro induces only a marginal stimulation of lhrh release . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "poa-mbh",
"pos": [
92,
99
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
199,
203
]
} |
the other newly characterized hypothalamic-hypophysiotropic peptide , growth hormone-releasing factor , hpgrf ( 1-40 ) , infused at a dose of 18 nmol x kg-1 x h-1 , did not modify gastric acid secretion stimulated by pentagastrin in rats . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
30,
42
]
} | {
"id": "C0037668",
"name": "growth",
"pos": [
70,
76
]
} |
using an enzyme-linked immunosorbent assay , we have demonstrated that purified human platelet thrombospondin formed a complex with purified human plasma histidine-rich glycoprotein . | tissue_is_expression_site_of_gene_product | {
"id": "C0005821",
"name": "platelet",
"pos": [
86,
94
]
} | {
"id": "C0076560",
"name": "thrombospondin",
"pos": [
95,
109
]
} |
we report a case of a prostatic urethral polyp that proved to be of prostatic epithelial differentiation , as demonstrated by immunohistochemical identification of prostatic acid phosphatase and prostatic specific antigen within the tumor cells . | tissue_is_expression_site_of_gene_product | {
"id": "C0033572",
"name": "prostatic",
"pos": [
22,
31
]
} | {
"id": "C0138741",
"name": "prostatic specific antigen",
"pos": [
195,
221
]
} |
formation of basement membranes during this development was followed by immunofluorescence and immunoperoxidase stainings using polyclonal and monoclonal antibodies against mouse and chick collagen type iv and against mouse laminin . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membranes",
"pos": [
13,
31
]
} | {
"id": "C0009333",
"name": "collagen type iv",
"pos": [
189,
205
]
} |
in the current study using monolayer cultures of neonatal rat islet cells , exogenous arachidonic acid ( aa ) ( 5 micrograms/ml ) potently stimulated insulin release in the presence of a substimulatory glucose concentration , and potentiated release induced by glucose . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "islet cells",
"pos": [
62,
73
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
150,
157
]
} |
the pretreatment of isolated islets of langerhans with concanavalin a ( con a ) completely blocks alloxan from suppressing the insulin release response to glucose . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "of",
"pos": [
17,
19
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
127,
134
]
} |
demonstration of lymphocyte chemotactic lymphokines in ppd-induced delayed hypersensitivity skin reaction site in the guinea-pig . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocyte",
"pos": [
17,
27
]
} | {
"id": "C0024297",
"name": "lymphokines",
"pos": [
40,
51
]
} |
the experiments were carried out to clarify whether lymphocyte chemotactic factors ( lcfs ) derived from activated lymphocytes , i.e . lymphocyte chemotactic lymphokines would exist in delayed-type hypersensitivity ( dth ) reaction sites in guinea-pigs . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocyte",
"pos": [
52,
62
]
} | {
"id": "C0024297",
"name": "lymphokines",
"pos": [
158,
169
]
} |
it is thus suggested that at least one of lymphocyte chemotactic lymphokines exists in the dth reaction sites and functions as lcf-c . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocyte",
"pos": [
42,
52
]
} | {
"id": "C0024297",
"name": "lymphokines",
"pos": [
65,
76
]
} |
further characterization of lymphocyte chemotactic lymphokines produced by purified protein derivative-stimulation in vitro and in vivo . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocyte",
"pos": [
28,
38
]
} | {
"id": "C0024297",
"name": "lymphokines",
"pos": [
51,
62
]
} |
as part of the american medical research expedition to everest in 1981 , we measured hemoglobin concentration , red cell 2,3-diphosphoglycerate ( 2,3-dpg ) , po2 at which hemoglobin is 50 % saturated ( p50 ) , and acid-base status in expedition members at various altitudes . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cell",
"pos": [
112,
120
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
171,
181
]
} |
on polyacrylamide gel electrophoresis under nondenaturing conditions , liver z protein gave rise to three bands , none of which was identical with the single band due to heart fatty acid binding protein . | tissue_is_expression_site_of_gene_product | {
"id": "C0023884",
"name": "liver",
"pos": [
71,
76
]
} | {
"id": "C1312696",
"name": "heart fatty",
"pos": [
170,
181
]
} |
among collagens , platelet ts bound to type v but not to types i , iii , or iv . | tissue_is_expression_site_of_gene_product | {
"id": "C0005821",
"name": "platelet",
"pos": [
18,
26
]
} | {
"id": "C0076560",
"name": "ts",
"pos": [
27,
29
]
} |
the hypothalamic content of lhrh ( 18 +/- 2.4 ng ) of bilaterally ovariectomized women ( 39-47 yr ) was significantly less ( p less than 0.001 ) than that ( 60 +/- 12.6 ng ) in younger ovulatory women ( 30-39 yr ) or that ( 56 +/- 13.5 ng ) in ovulatory women of comparable age ( 40-49 yr ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
4,
16
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
28,
32
]
} |
the effect of six hypothalamic peptides on the basal release of acth and that induced by arginine vasopressin ( avp ) or by ovine corticotrophin releasing factor ( ocrf ) from fragments of the rat anterior pituitary gland incubated in vitro was investigated . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
18,
30
]
} | {
"id": "C0010132",
"name": "corticotrophin releasing",
"pos": [
130,
154
]
} |
it is concluded that corticosterone impairs ca2+ inflow into the islet cells and , by doing so , causes a progressive inhibition of insulin release . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "islet",
"pos": [
65,
70
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
132,
139
]
} |
1-formylpyridine monothiosemicarbazonato copper ii ( cul+ ) is readily taken up by red cells and is initially bound to glutathione and hemoglobin . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cells",
"pos": [
83,
92
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
135,
145
]
} |
in busulfan-treated rats , compared to controls , hypothalamic lh-rh content was decreased by 52 % , whereas pituitary lh and fsh concentrations were increased by 60 and 43 % respectively . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
50,
62
]
} | {
"id": "C0023610",
"name": "lh-rh",
"pos": [
63,
68
]
} |
such neurones are found mainly in the arcuate nucleus in human and monkey hypothalamus , suggesting that this nucleus is a primary source of grf . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
74,
86
]
} | {
"id": "C0037668",
"name": "grf",
"pos": [
141,
144
]
} |
we have further investigated this hypothesis by studying the anatomical organization of grf neurones in rat hypothalamus , using an antibody raised against the recently characterized rat hypothalamic grf in normal animals and in animals neonatally treated with monosodium glutamate ( msg ) , a treatment which results in the selective destruction of arcuate nucleus neurones . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
187,
199
]
} | {
"id": "C0037668",
"name": "grf",
"pos": [
200,
203
]
} |
these results suggest that clonidine stimulates rat gh secretion , possibly by acting within the hypothalamus to stimulate gh releasing factor neurons . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
97,
109
]
} | {
"id": "C0037668",
"name": "gh releasing factor",
"pos": [
123,
142
]
} |
this study evaluated the influence of exogenous estrogen administered during this time on the hypothalamic lhrh content and on gonadotropin secretion in adult male and female rats . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
94,
106
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
107,
111
]
} |
pituitaries from cannabinoid-exposed males were less responsive to lh releasing hormone ( rh ) stimulation , however , hypothalamic lhrh content was significantly higher in the thc-exposed males . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
119,
131
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
132,
136
]
} |
in this study following a segmental pancreatic autotransplant to the iliac fossa in dogs , a combined analysis of three pancreatic islet hormones , insulin , pancreatic polypeptide ( pp ) and glucagon was undertaken by radioimmunoassay of plasma . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "pancreatic islet",
"pos": [
120,
136
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
148,
155
]
} |
relationship between thyroid volume and serum thyroglobulin during long-term suppression with triiodothyronine in patients with diffuse non-toxic goitre . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
21,
28
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
46,
59
]
} |
twenty-five patients with non-toxic diffuse goitre were studied during and after 12 months of treatment with 60 micrograms triiodothyronine daily in order to see whether a correlation could be found between the reductions of thyroid volume , using ultrasonic scanning , and serum thyroglobulin . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
225,
232
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
280,
293
]
} |
k+ depletion caused a cation deficit of up to 30 % of total red cell na+ plus k+ and a consecutive cell shrinkage with an increase in mean cellular hemoglobin content ( mchc ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cell",
"pos": [
60,
68
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
148,
158
]
} |
hematologic values , red blood cell ( rbc ) organic phosphate composition , hemoglobin function , and hemoglobin composition have been determined on blood from the monotremes , the duckbill platypus and the echidna , and three species of marsupials , the tasmanian devil , the wallaby , and the brush-tail possum . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red blood cell",
"pos": [
21,
35
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
102,
112
]
} |
the rbcs from the monotremes and the three marsupials exhibited hemoglobin polymorphism , each with three hemoglobin components . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "rbcs",
"pos": [
4,
8
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
106,
116
]
} |
the t3-predominant patients had greater serum tsh receptor antibody activity , thyroid t4 5'-deiodinase activity , and decreased t3 content of thyroglobulin when compared with the control patients . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
79,
86
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
143,
156
]
} |
examination of t-lymphocyte populations , lymphocyte dna synthesis , and lymphokine production in response to mitogen stimulation revealed no differences between the sixty patients and matched healthy control subjects . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocyte",
"pos": [
17,
27
]
} | {
"id": "C0024297",
"name": "lymphokine",
"pos": [
73,
83
]
} |
sequential immunoprecipitation experiments implied the existence of only a single somatostatin precursor among the rat hypothalamic translation products , which would have to be differentially processed to allow release of both srif-28 and srif-14 . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
119,
131
]
} | {
"id": "C0037659",
"name": "srif",
"pos": [
240,
244
]
} |
purified lymphocytes did not assume mast cell characteristics , and lymphokines did not induce or enhance in vitro mast cell development or ige binding . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocytes",
"pos": [
9,
20
]
} | {
"id": "C0024297",
"name": "lymphokines",
"pos": [
68,
79
]
} |
together with the phosphorylation data , these findings suggest that this islet cell cytokeratin may be involved in the regulation of insulin release . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "islet cell",
"pos": [
74,
84
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
134,
141
]
} |
and 3 ) the decreased lh and fsh pulse frequency with t treatment implies that t or a metabolite of t acts on the central nervous system to slow the hypothalamic lhrh pulse generator . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
149,
161
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
162,
166
]
} |
all 4 patients with hypothalamic hypopituitarism had exaggerated plasma acth responses to crf compared to normal subjects and gradual but definite increases in plasma cortisol from low basal levels . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
20,
32
]
} | {
"id": "C0010132",
"name": "acth",
"pos": [
72,
76
]
} |
the role of lymphocytes in the pathogenesis of bullous pemphigoid was examined by assaying the blister fluid obtained from bullous pemphigoid patients for the presence of the lymphokine , lymphotoxin . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocytes",
"pos": [
12,
23
]
} | {
"id": "C0024297",
"name": "lymphokine",
"pos": [
175,
185
]
} |
with respect to the destructive phase of periodontal disease , it is clear that the direct effect of lymphocytes mediated either through direct cytotoxic activity , or through biologically-active destructive lymphokines ( such as alpha-lymphotoxin and osteoclast activating factor ) , can lead to tissue destruction . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocytes",
"pos": [
101,
112
]
} | {
"id": "C0024297",
"name": "lymphokines",
"pos": [
208,
219
]
} |
the ability to reliably quantitate lymphotoxin secretion using refrigerated lymphocytes permits transport of lymphocytes to laboratories performing quantitative bioassay of the lymphokine . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocytes",
"pos": [
76,
87
]
} | {
"id": "C0024297",
"name": "lymphokine",
"pos": [
177,
187
]
} |
the bm around the tumor aggregates contained both laminin and type iv collagen , and was continuous and distinct in all the nonfibrosing bccs but indistinct or interrupted in the fibrosing bccs and bscs . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "bm",
"pos": [
4,
6
]
} | {
"id": "C0009333",
"name": "type iv collagen",
"pos": [
62,
78
]
} |
cysteamine administration to rats results in a marked depletion of hypothalamic somatostatin-14 ( ss14 ) and a decrease of the potassium-evoked in vitro release of ss14 without a significant change in the content or release of somatostatin-28 ( 1-12 ) -like immunoreactivity ( ss28 ( 1-12 ) -l1 ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
67,
79
]
} | {
"id": "C0037659",
"name": "ss14",
"pos": [
164,
168
]
} |
immunohistochemical visualization of hypothalamic neuronal cell bodies and fibers following cysteamine administration shows a disappearance of the ss14 immunoreactive fibers and cell bodies with no apparent change in the ss28 ( 1-12 ) immunoreactive fibers and cell bodies . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
37,
49
]
} | {
"id": "C0037659",
"name": "ss14",
"pos": [
147,
151
]
} |
these data suggest that , in rat hypothalamus , selective release of ss14 and ss28 ( 1-12 ) can occur . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
33,
45
]
} | {
"id": "C0037659",
"name": "ss14",
"pos": [
69,
73
]
} |
hypothalamic synaptosomes prepared from intact 6-ohda-treated animals consistently released less lhrh than did controls although the difference was not significant . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
0,
12
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
97,
101
]
} |
the results indicate that depletion of hypothalamic noradrenaline causes subtle changes in the endogenous release of lhrh and may alter the negative feedback effects of steroids on the hypothalamic-pituitary axis . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
39,
51
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
117,
121
]
} |
hypothalamic and pituitary cytosol oestrogen receptor number , median eminence gnrh content and pituitary lh , fsh and prolactin contents were similar in the two groups of ewes . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
0,
12
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
79,
83
]
} |
to study the physiological role of the bidirectionally operating , furosemide-sensitive na+/k+ transport system of human erythrocytes , the effect of furosemide on red cell cation and hemoglobin content was determined in cells incubated for 24 hr with ouabain in 145 mm nacl media containing 0 to 10 mm k+ or rb+ . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cell",
"pos": [
164,
172
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
184,
194
]
} |
the in vivo red cell k+ content was negatively correlated to the rate of furosemide-sensitive k+ ( rb+ ) uptake , and a positive correlation was seen between mean cellular hemoglobin content and furosemide-sensitive transport activity . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cell",
"pos": [
12,
20
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
172,
182
]
} |
although lymphocyte blastogenesis with phytohemagglutinin ( pha ) was inhibited by high concentrations of nhg-1 , augmentation of the lymphocyte pha response was seen at lower concentrations , suggesting a lymphokine-like effect . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocyte",
"pos": [
9,
19
]
} | {
"id": "C0024297",
"name": "lymphokine",
"pos": [
206,
216
]
} |
erythrocyte 2,3-diphosphoglycerate , po250 % , and available oxygen in young rabbits with and without postnatal fall in hemoglobin . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
0,
11
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
120,
130
]
} |
the gliclazide-induced facilitation of ca2+ inflow into the islet cells and the subsequent stimulation of insulin release , whatever their precise molecular determinants , thus displayed the same dependency towards extracellular ph as that characterizing the ionophoretic action of the drug . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "islet cells",
"pos": [
60,
71
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
106,
113
]
} |
the number concentration of erythrocytes in blood ( rbc ) and the discrimination functions mcv/rbc , ( mcv ) 2 x mch , df = ( mcv/fl ) - ( rbc/10 ( 12 ) .1 ( -1 ] - ( 8.1 x hb mmol.1 ( -1 ] - 3.4 have been advocated as useful methods in screening programmes for thalassaemia . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "rbc",
"pos": [
52,
55
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
173,
175
]
} |
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