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|---|---|---|---|
endothelial cells from human umbilical cord were cultured to study plasminogen activator synthesis and secretion . | tissue_is_expression_site_of_gene_product | {
"id": "C0225336",
"name": "endothelial cells",
"pos": [
0,
17
]
} | {
"id": "C0032144",
"name": "plasminogen",
"pos": [
67,
78
]
} |
after total ablation of thyroid tissue , serum tg determination is useful in separating patients in remission from those with residual metastatic disease . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
24,
31
]
} | {
"id": "C0040123",
"name": "tg",
"pos": [
47,
49
]
} |
in a hormonal system stimulated by one of the known hypothalamic peptides , gonadotropin releasing hormone ( gnrh ) , the biological response seen , when physiologically called for , may be positively co-operative , showing as well the expected dynamics due to a singular or continuing stimulus . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
52,
64
]
} | {
"id": "C0023610",
"name": "gonadotropin releasing hormone",
"pos": [
76,
106
]
} |
after 6 and 12 days in continuous perfusion , both cortical and hypothalamic cells demonstrated immuno-reactive ss release following 60 mmk+ depolarization ( 5- to 7-fold increase from basal secretion levels of 15-20 pg/3 x 10 ( 7 ) cells/10 min ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
64,
76
]
} | {
"id": "C0037659",
"name": "ss",
"pos": [
112,
114
]
} |
the role of hypothalamic catecholamines and luteinizing hormone releasing hormone ( lhrh ) in the negative feedback effect of estradiol benzoate ( eb ) on luteinizing hormone ( lh ) release was studied in chronic ovariectomized rats . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
12,
24
]
} | {
"id": "C0023610",
"name": "luteinizing hormone releasing",
"pos": [
44,
73
]
} |
these hpgrfs are indistinguishable from partially purified preparations of hypothalamic growth hormone releasing factor of human , porcine and murine origins with respect to biological activity and are very similar in their physicochemical properties ( molecular weight , retention behavior on reverse-phase hplc , absence of sulfhydryl groups ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
75,
87
]
} | {
"id": "C0037668",
"name": "growth hormone releasing factor",
"pos": [
88,
119
]
} |
a dual action of estrogens in modifying the pituitary gonadotrophins , as well as hypothalamic lh -- rh release was supposed . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
82,
94
]
} | {
"id": "C0023610",
"name": "lh",
"pos": [
95,
97
]
} |
[ treatment of sterility of hypothalamic origin by pulsatile injection of gnrh . use of a portable pump ] . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
28,
40
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
74,
78
]
} |
the arrangement of the various endocrine cells within mammalian islets of langerhans indicates that the regulation of insulin and glucagon secretion by pancreatic somatostatin may occur mainly by paracrine mechanisms . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "islets of",
"pos": [
64,
73
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
118,
125
]
} |
basement membrane macromolecules , including type iv collagen , laminin , and heparan sulfate proteoglycan , do not aggregate when incubated alone . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membrane",
"pos": [
0,
17
]
} | {
"id": "C0009333",
"name": "type iv collagen",
"pos": [
45,
61
]
} |
it has been established that under hbo the concentration of ferro-containing proteins increases , the fraction composition of serum and erythrocyte haemoglobin changes , the activity of acid peptide-hydrolases increases and the protamine-splitting peptide-hydrolase activity lowers . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
136,
147
]
} | {
"id": "C0019046",
"name": "haemoglobin",
"pos": [
148,
159
]
} |
hypothalamic lhrh and plasma lh levels after electrical stimulation of the deafferented medial basal hypothalamus . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
0,
12
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
13,
17
]
} |
the patients belonging to all of the 5 groups had less amounts of hair copper ( p less than 0.05 ) and erythrocyte hemoglobin ( p less than 0.01 ) in comparison to controls . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
103,
114
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
115,
125
]
} |
these data indicate that pituitary gnrh receptors are modulated by gonadal steroids from day 10 of life in both sexes and that the mechanism involves modification of hypothalamic gnrh secretion . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
166,
178
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
179,
183
]
} |
during incubations at 37 degrees c in appropriate media ( buffered 0.25 m sucrose ) isolated thyroid phagolysosomes degrade the thyroglobulin they contain ( labelled with 131i in vivo ) giving rise to trichloroacetic-acid-soluble radio-iodine . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
93,
100
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
128,
141
]
} |
since dopaminergic cell bodies in the ventral hypothalamus are closely apposed by gnrh and gad containing fibers , the existence of feedback circuits among gnrh , dopamine and gaba systems is proposed . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
46,
58
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
156,
160
]
} |
in both a- and a-i- groups , thyroid cytosol 3h-rpm ( retinyl-phosphate-mannose ) and 3h-mannose incorporation into the core of the 12s-tg and 19s-tg species were reduced by 40-50 % . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
29,
36
]
} | {
"id": "C0040123",
"name": "tg",
"pos": [
147,
149
]
} |
within a culture period of 4-6 days the islet cells reaggregate spontaneously and form pseudo-islets of different size and of a variable insulin content . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "islet cells",
"pos": [
40,
51
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
137,
144
]
} |
while the ratio of insulin to glucagon in isolated islets of langerhans is constant ( 18 +/- 1.9 ) , the hormone ratio of the pseudo-islets is strongly variable and increased , indicating an excess of insulin . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "islets of langerhans",
"pos": [
51,
71
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
201,
208
]
} |
highly purified recombinant fibroblast interferon produced by escherichia coli ( reifn-beta ) was tested for its ability to stimulate natural killer ( nk ) cell activity , antibody-dependent cell-mediated cytotoxicity ( adcc ) and monocyte-macrophage phagocytic activity in human peripheral blood mononuclear cells ( pbm ) in comparison with natural human fibroblast interferon ( ifn-beta ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0024432",
"name": "activity",
"pos": [
161,
169
]
} | {
"id": "C0015980",
"name": "ifn-beta",
"pos": [
380,
388
]
} |
these same enzyme-pretreated target cells , however , were unaffected in their ability to bind a natural killer cell-derived cytolytic factor ( nkcf ) molecule ( s ) , as determined by direct nkcf absorption studies or by their ability to cold target compete for the binding of nkcf to another nkcf-sensitive cell , the l929 fibroblast , thereby indicating that the k562 `` '' target antigen '' '' and the nkcf-receptor are independently expressed structures . | tissue_is_expression_site_of_gene_product | {
"id": "C0022688",
"name": "nkcf",
"pos": [
144,
148
]
} | {
"id": "C0382839",
"name": "nkcf-recept",
"pos": [
406,
417
]
} |
the 2-site sandwich radioimmunoassay detected , with a high sensitivity , ifn-beta either induced from fibroblast or produced by escherichia coli harboring the gene of ifn-beta . | tissue_is_expression_site_of_gene_product | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
103,
113
]
} | {
"id": "C0015980",
"name": "ifn-beta",
"pos": [
168,
176
]
} |
bursal rep cells were also positive for a gut-associated mucin , but this may have been bound in vivo prior to culture . | tissue_is_expression_site_of_gene_product | {
"id": "C0014597",
"name": "rep cells",
"pos": [
7,
16
]
} | {
"id": "C0026682",
"name": "mucin",
"pos": [
57,
62
]
} |
a time-course study showed that cultivation of the lymphocytes for 1 1/2 days completed the release of their leishmanicidal lymphokines which were heat-labile molecules larger than 50,000 daltons . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocytes",
"pos": [
51,
62
]
} | {
"id": "C0024297",
"name": "lymphokines",
"pos": [
124,
135
]
} |
the assay is based on the measurement of enzymatically formed uridine in erythrocyte hemolysates ( 10-50 microliter ) and produces a linear activity curve from 5 to 1000 microm/g hb/h . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
73,
84
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
179,
181
]
} |
the generation of specific cytotoxic responses by human lymphocytes requires antigen and activities provided by a lymphokine supernatant . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocytes",
"pos": [
56,
67
]
} | {
"id": "C0024297",
"name": "lymphokine",
"pos": [
114,
124
]
} |
it is concluded that enflurane in the concentration range used clinically leads to a rapid , reversible inhibition of rat pancreatic islet insulin release , which is not attributable to interference with islet glucose metabolism or protein biosynthesis . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "pancreatic islet",
"pos": [
122,
138
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
139,
146
]
} |
from these data it is concluded that less than 1 % of plasma protoporphyrin is bound to haemopexin . | tissue_is_expression_site_of_gene_product | {
"id": "C0032105",
"name": "plasma",
"pos": [
54,
60
]
} | {
"id": "C0019067",
"name": "haemopexin",
"pos": [
88,
98
]
} |
changes in hemoglobin status and lipid peroxidation were followed in red cells containing either oxy-met- , or carbonmonoxyhemoglobin , incubated with t-butyl hydroperoxide in a medium with or without glucose . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cells",
"pos": [
69,
78
]
} | {
"id": "C0007061",
"name": "carbonmonoxyhemoglobin",
"pos": [
111,
133
]
} |
loss of intact hemoglobin ( the sum of oxyhemoglobin and methemoglobin ) was inversely proportional to the degree of lipid peroxidation in red cells containing either oxy- or methemoglobin . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cells",
"pos": [
139,
148
]
} | {
"id": "C0025635",
"name": "methemoglobin",
"pos": [
175,
188
]
} |
when glucose was added to the medium , lipid peroxidation increased while there was a decreased loss of intact hemoglobin in red cells containing either oxy- or methemoglobin , while both lipid peroxidation and changes in hemoglobin decreased in red cells containing carbonmonoxyhemoglobin . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cells",
"pos": [
125,
134
]
} | {
"id": "C0007061",
"name": "carbonmonoxyhemoglobin",
"pos": [
267,
289
]
} |
methemoglobin formation and loss of intact hemoglobin were directly proportional to the degree of lipid peroxidation in red cells containing carbonmonoxyhemoglobin . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cells",
"pos": [
120,
129
]
} | {
"id": "C0007061",
"name": "carbonmonoxyhemoglobin",
"pos": [
141,
163
]
} |
the greatest amount of lipid peroxidation occurred in red cells containing carbonmonoxyhemoglobin , incubated without glucose . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cells",
"pos": [
54,
63
]
} | {
"id": "C0007061",
"name": "carbonmonoxyhemoglobin",
"pos": [
75,
97
]
} |
red cell lysis induced by microorganisms as a case of superoxide- and hydrogen peroxide-dependent hemolysis mediated by oxyhemoglobin . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cell",
"pos": [
0,
8
]
} | {
"id": "C0030069",
"name": "oxyhemoglobin",
"pos": [
120,
133
]
} |
it is concluded that in fetal rats recently differentiated lh cells can release the secretory product if they are stimulated by hypothalamic lhrh . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
128,
140
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
141,
145
]
} |
thyroglobulin antibodies failed to stain viable thyroid monolayers , even when these were previously incubated with purified human thyroglobulin , indicating that this protein or possible receptors for it can not be detected on the cell surface under these conditions . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
48,
55
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
131,
144
]
} |
the effect of hypothalamic somatostatin is likely to inhibit such a response at the pituitary level in older rats . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
14,
26
]
} | {
"id": "C0037659",
"name": "somatostatin",
"pos": [
27,
39
]
} |
these data indicate that the collagenous matrix of basement membranes consists of a regular network of type iv collagen molecules which is generated by two different interacting sites located at opposite ends of each molecule . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membranes",
"pos": [
51,
69
]
} | {
"id": "C0009333",
"name": "type iv collagen",
"pos": [
103,
119
]
} |
these studies suggest that aromatization of t to e is not indispensable to the negative feedback effect of androgen on the hypothalamic lh-rh release . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
123,
135
]
} | {
"id": "C0023610",
"name": "lh-rh",
"pos": [
136,
141
]
} |
collectively , these data indicate that dnfb-immune t cells express a receptor specific for the hapten dnp and provide evidence that supports a two-receptor model for t cell recognition of antigen . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
52,
59
]
} | {
"id": "C0034790",
"name": "receptor",
"pos": [
148,
156
]
} |
other fc receptor ( fcr ) -bearing lymphocytes , including natural killer ( nk ) cells , do not produce measurable lif activity when incubated with immune complexes ( additional evidence that the k and nk cells among ligands to the fcr of the appropriate lymphocytes , possibly without need for exogenous receptor bridging , is the only requirement for their activation to immune complex-induced lymphokine production ( iclp ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocytes",
"pos": [
35,
46
]
} | {
"id": "C0024297",
"name": "lymphokine",
"pos": [
396,
406
]
} |
rbc , hb , an ht of the female workers in the petroleum solvents workshops were lower than those in perchloroethylene workshops . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "rbc",
"pos": [
0,
3
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
6,
8
]
} |
erythrocyte levels of ala-dehydrase and uro-synthetase as well as hematocrit , hemoglobin , iron levels and serum iron binding capacity were studied in a group of 28 patients with chronic renal failure in hemodialysis and compared to those of a control group . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
0,
11
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
79,
89
]
} |
differential effects of low serum levels of estradiol-17 beta on hypothalamic lhrh levels and lh secretion in castrated male rats . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
65,
77
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
78,
82
]
} |
the diminution in the rise in plasma lh levels and the decreased amplitude and/or frequency of lh pulses in the msg-treated rats is likely due to a diminution in hypothalamic lhrh release . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
162,
174
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
175,
179
]
} |
effects of alloxan on the islets of langerhans : why does alloxan not stimulate insulin release ? | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "islets of langerhans",
"pos": [
26,
46
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
80,
87
]
} |
multifocal infiltrations of lymphocytes and macrophages were present in the thyroid glands of dogs 1 month after an intrathyroidal injection ( 0.5 ml ) of canine serum containing thyroglobulin autoantibodies . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid glands",
"pos": [
76,
90
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
179,
192
]
} |
the data are consistent with the findings that the hypothalamic-pituitary-gonadal inhibitory system functions earlier in the male than in the female and that the lhrh system can be modified by estrogen circulating during the period of sexual differentiation . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
51,
63
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
162,
166
]
} |
[ respiration of isolated epithelial cells of the rat intestine : inhibiting effect of tannin and protective effect of mucin ] . | tissue_is_expression_site_of_gene_product | {
"id": "C0014597",
"name": "epithelial cells",
"pos": [
26,
42
]
} | {
"id": "C0026682",
"name": "mucin",
"pos": [
119,
124
]
} |
the hypothalamic extract or lh-rh injected into the cannulas of such animals leads to rapid peaks of lh in peripheral blood removed from the same cannulas within 6 to 8 min , followed by a slow decrease . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
4,
16
]
} | {
"id": "C0023610",
"name": "lh-rh",
"pos": [
28,
33
]
} |
the present studies have demonstrated that the growth hormone releaseinhibiting factor of the hypothalamus , somatostatin , exerts a prominent inhibiting action on glucose induced insulin release in man . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
94,
106
]
} | {
"id": "C0037659",
"name": "somatostatin",
"pos": [
109,
121
]
} |
when zucker obese rats are fed precisely the same amount of carbohydrate as lean controls and allowed to become obese by drinking vegetable oil , their pancreatic islets still release 59 % more insulin than do those from lean controls . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "pancreatic islets",
"pos": [
152,
169
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
194,
201
]
} |
in view of the impaired erythrocyte defense capacity against oxidative injury , cell content rigidity as mediated by reduced hemoglobin solubility is a more likely explanation . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
24,
35
]
} | {
"id": "C0057437",
"name": "solubility",
"pos": [
136,
146
]
} |
an increased retention of hemoglobin in preparations of membranes from red cells of patients with sickle cell anemia ( homozygote s ) was attributable to the dense fraction of homozygote s red cells rich in irreversibly sickled cells , and the latter membranes had a smaller residual binding capacity for new hemoglobin . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cells",
"pos": [
71,
80
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
309,
319
]
} |
the plasma distribution curves of 125i-hemopexin , after the first 24 hours , showed essentially no difference . | tissue_is_expression_site_of_gene_product | {
"id": "C0032105",
"name": "plasma",
"pos": [
4,
10
]
} | {
"id": "C0019067",
"name": "hemopexin",
"pos": [
39,
48
]
} |
in contrast , injection of heme had little if any effect on the plasma radioactivity curve of photoinactivated 125i-hemopexin . | tissue_is_expression_site_of_gene_product | {
"id": "C0032105",
"name": "plasma",
"pos": [
64,
70
]
} | {
"id": "C0019067",
"name": "hemopexin",
"pos": [
116,
125
]
} |
taken together , these observations provide further definition of the chemotactic behavior of basophils in general , and underscore some of the ways in which lymphocytes can influence basophils through lymphokine-dependent mechanisms . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocytes",
"pos": [
158,
169
]
} | {
"id": "C0024297",
"name": "lymphokine",
"pos": [
202,
212
]
} |
effect of hemoglobin and hematin on plasma clearance of hemopexin , photo-inactivated hemopexin and albumin ( 38575 ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0032105",
"name": "plasma",
"pos": [
36,
42
]
} | {
"id": "C0019067",
"name": "hemopexin",
"pos": [
86,
95
]
} |
the plasma half clearance time ( t1/2 ) of isotope-labeled rabbit hemopexin was 35.5 plus or minus 1.9 hr in rabbits . | tissue_is_expression_site_of_gene_product | {
"id": "C0032105",
"name": "plasma",
"pos": [
4,
10
]
} | {
"id": "C0019067",
"name": "hemopexin",
"pos": [
66,
75
]
} |
low serum and erythrocyte folate values were significantly more common in 61 sickle-cell patients than in each of the two socio-economically-matched control groups including 61 subjects with hb as and 69 blacks with hb aa . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
14,
25
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
216,
218
]
} |
within the hypothalamus , the concentration of srif was highest in the median eminence and arcuate nucleus although all of the hypothalmic nuclei contained some fo this material . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
11,
23
]
} | {
"id": "C0037659",
"name": "srif",
"pos": [
47,
51
]
} |
oxygen content of erythrocytic hemoglobin ( ehb ) and extraerythrocytic hemoglobin ( eehb ) resulting from infusions of wxb8326 was studied in arterial and venous blood at different levels of hemodilution . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocytic",
"pos": [
18,
30
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
72,
82
]
} |
wxb8326 did not interfere with the arterial oxygen saturation of ehb in the pulmonary vascular bed and eehb was oxygenated as efficiently as ehb . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "ehb",
"pos": [
65,
68
]
} | {
"id": "C0019046",
"name": "ehb",
"pos": [
141,
144
]
} |
erythrocytic hemoglobin met oxygen demands under basal conditions while eehb contributed oxygen to tissues during conditions of high oxygen extraction . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocytic",
"pos": [
0,
12
]
} | {
"id": "C0019046",
"name": "eehb",
"pos": [
72,
76
]
} |
storage of red cells in acid-citrate-dextrose ( acd ) solution for more than a week has been shown to cause a reduction in red cell 2,3-diphosphoglycerate ( 2,3-dpg ) , resulting in a decrease in the half-saturation pressure ( p50 ) of stored blood , thus increasing hemoglobin-oxygen affinity and theoretically decreasing oxygen delivery to the tissues . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cell",
"pos": [
11,
19
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
267,
277
]
} |
it was shown that prolonged administration of sympatholytics ( ornide or actadine ) and also of a blocker of the alpha-adrenorecptors with phentholamine or of beta-adrenoreceptors with inderal led to the accumulation of zinc in the cytoplasm of beta-cells , reduction of the content in them of specific aldehyde-fuchsinophilic granularity , neoformation of the islands of langerhans and to increase in the animal sensitivity to the exogenous insulin . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "of",
"pos": [
43,
45
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
442,
449
]
} |
macrophage migration inhibition factor ( mif ) is one of a class of lymphocyte-derived mediator substances ( lymphokines ) which plays a role in the mechanism of cellular immunity . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocyte",
"pos": [
68,
78
]
} | {
"id": "C0024297",
"name": "lymphokines",
"pos": [
109,
120
]
} |
a linearity was demonstrated for immunoreactive gh-rih of extracts of rat and pig hypothalami , indicating that they contained substance ( s ) indistinguishable from gh-rih . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalami",
"pos": [
82,
93
]
} | {
"id": "C0037659",
"name": "gh-rih",
"pos": [
166,
172
]
} |
various hypothalamic and pituitary hormones did not interfere with the radioimmunoassay , but considerable cross-reaction was observed for linear gh-rih and the ring portion of gih-rih , suggesting that the antigenic determinant involved the amino acid sequence from position 3-14 of gh-rih or part of it . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
8,
20
]
} | {
"id": "C0037659",
"name": "gh-rih",
"pos": [
284,
290
]
} |
resting levels of erythrocyte 2,3-dpg were established in thoroughbred horses , and levels of 2,3-dpg together with haemoglobin levels , were examined in a variety of conditions . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
18,
29
]
} | {
"id": "C0019046",
"name": "haemoglobin",
"pos": [
116,
127
]
} |
red cell 2,3-diphosphoglycerate ( 2,3-dpg ) and the oxygen haemoglobin dissociation curve ( odc ) were determined in 32 ambulatory , non-acidotic diabetic children and in 49 healthy children . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cell",
"pos": [
0,
8
]
} | {
"id": "C0019046",
"name": "haemoglobin",
"pos": [
59,
70
]
} |
one system involved the effects of the administered drugs on rat prostatic 5 alpha-reductase and arginase activities . | tissue_is_expression_site_of_gene_product | {
"id": "C0033572",
"name": "prostatic",
"pos": [
65,
74
]
} | {
"id": "C0039602",
"name": "5 alpha-reductase",
"pos": [
75,
92
]
} |
in other areas of the hypothalamus surrounding the suprachiasmatic area , supraoptic area , paraventricular nuclei and the anterior hypothalamic area , the lh-rh neurons are few and scattered . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
22,
34
]
} | {
"id": "C0023610",
"name": "lh-rh",
"pos": [
156,
161
]
} |
lymphocytes were stimulated with concanavalin a , the culture supernatant was chromatographed over sephadex g-100 and the fraction of mol wt 25,000-55,000 , rich in lymphocyte mediators , was cultured with normal guinea pig macrophages for 1-3 days . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocytes",
"pos": [
0,
11
]
} | {
"id": "C0024297",
"name": "lymphocyte mediators",
"pos": [
165,
185
]
} |
red cell , 2,3-diphosphoglycerate concentration ( 16.9 vs 15.1 mumol/g hb ; p less than 0.01 ) and the haemoglobin-oxygen affinity measured by po2 at 50 % oxygen saturation ( p50 ) had also increased significantly ( 27.5 vs 26.3 mmhg ; p less than 0.01 ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cell",
"pos": [
0,
8
]
} | {
"id": "C0019046",
"name": "haemoglobin",
"pos": [
103,
114
]
} |
it is concluded that rat pancreatic islets possess insulin because binding and biological potency of substances related to insulin were in harmony . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "pancreatic islets",
"pos": [
25,
42
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
123,
130
]
} |
thus , basement membranes may differ in their content of type iv collagen , or in the way in which it is assembled . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membranes",
"pos": [
7,
25
]
} | {
"id": "C0009333",
"name": "type iv",
"pos": [
57,
64
]
} |
amenorrhoea of high origin , namely hypothalamic , reflects inhibition or a drop in endogenous secretion of gn-rh . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
36,
48
]
} | {
"id": "C0023610",
"name": "gn-rh",
"pos": [
108,
113
]
} |
the time course data and the differential production of activities by the three types of lymphocyte clones suggest that at least four terminal effector lymphokine molecules account for the ten biologic activities tested . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocyte",
"pos": [
89,
99
]
} | {
"id": "C0024297",
"name": "lymphokine",
"pos": [
152,
162
]
} |
the mechanisms responsible for the accumulation of lymphocytes in rejecting allografts may involve lymphokine-mediated changes in blood flow and vascular permeability . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocytes",
"pos": [
51,
62
]
} | {
"id": "C0024297",
"name": "lymphokine",
"pos": [
99,
109
]
} |
these results are consistent with the idea that the interaction between ssl and specific alloantigen in vivo leads to the rapid elaboration of lymphokines , which increases rbf and vp , in addition to the accumulation of circulating unsensitized cells . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "ssl",
"pos": [
72,
75
]
} | {
"id": "C0024297",
"name": "lymphokines",
"pos": [
143,
154
]
} |
evidence that lectin-binding sites are present on the surface of isolated hypothalamic granules containing luteinizing hormone-releasing hormone . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
74,
86
]
} | {
"id": "C0023610",
"name": "luteinizing hormone-releasing hormone",
"pos": [
107,
144
]
} |
in the present study , we wished to ascertain if lectin-binding sites are present on hypothalamic granules containing luteinizing hormone-releasing hormone ( lhrh ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
85,
97
]
} | {
"id": "C0023610",
"name": "luteinizing hormone-releasing hormone",
"pos": [
118,
155
]
} |
t-cells and t-cells with receptors for igmfc ( t mu ) , iggfc ( t gamma ) , or igafc ( t alpha ) in the peripheral blood and regional lymph nodes of patients with untreated breast cancer . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t-cells",
"pos": [
0,
7
]
} | {
"id": "C0034790",
"name": "t-cells",
"pos": [
12,
19
]
} |
common hypothalamic sites for activation of sexual receptivity in female rats by lhrh , pge2 and progesterone . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
7,
19
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
81,
85
]
} |
the immune complexes and antigen-antibody complexes respectively could bind reversibly to t cells via fc-receptors and subsequently interfere with the t cell receptors for se by steric hindrance . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
90,
97
]
} | {
"id": "C0034790",
"name": "t cell receptors",
"pos": [
151,
167
]
} |
temperature independence of the alkaline bohr effect in pig red cells and pig haemoglobin solutions . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cells",
"pos": [
60,
69
]
} | {
"id": "C0019046",
"name": "haemoglobin",
"pos": [
78,
89
]
} |
the influence of temperature on the oxygen affinity and the alkaline bohr effect of pig red cells and pig hemoglobin solutions has been compared to that of human adult red cells and human adult hemoglobin . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cells",
"pos": [
88,
97
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
194,
204
]
} |
pig red cells and pig hb evidence a lower affinity for oxygen in various conditions of ph , temperature and salt concentration , in the presence as well as in the absence of organic phosphates . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cells",
"pos": [
4,
13
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
22,
24
]
} |
in plasma , the signals of transferrin ( g approximately 4.26 ) , ceruloplasmin ( g approximately 2.05 ) , and fr ( g approximately 2.0024-2.0029 and delta h 6-8 oe ) were registered , while in red cells , the signals of hemoglobin ( g approximately 6.00 ) , superoxide dismutase ( g approximately 2.063 ) , and flavosemiquinone ( g approximately 2.0030-2.0040 and delta h 12-15 oe ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red",
"pos": [
179,
182
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
221,
231
]
} |
stress or other adenohypophyseal mechanisms involving the release of acth or prolactin do not explain the effects of ischemia found in the present study . | tissue_is_expression_site_of_gene_product | {
"id": "C0032008",
"name": "adenohypophyseal",
"pos": [
16,
32
]
} | {
"id": "C0033371",
"name": "prolactin",
"pos": [
77,
86
]
} |
acidified methanolic extracts , prepared from human milk , bovine colostrum and rat hypothalami , as well as synthetic lhrh and trh markers were subjected to high-pressure liquid chromatography ( hplc ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalami",
"pos": [
84,
95
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
119,
123
]
} |
even in complete surgical isolation of the mbh , separate fibers of the luliberinergic cells penetrate into the mbh maintaining there a certain amount of luliberin and preserving synthesis of the luteinizing hormone in the hypophysis with its decreased release into the blood . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "mbh",
"pos": [
43,
46
]
} | {
"id": "C0023610",
"name": "luliberin",
"pos": [
154,
163
]
} |
pancreatic islets were isolated from individual neonatal ( 2-5 days of age ) lean and preobese zucker rats to assess insulin and glucagon release were elicited with high glucose ( 22.2 mm ) plus aminophylline ( 10 mm ) and alanine ( 10 mm ) , respectively . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "pancreatic islets",
"pos": [
0,
17
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
117,
124
]
} |
by shift to the nonpermissive temperature , these cells could be induced to differentiate into erythrocyte-like cells which expressed embryonic haemoglobins . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
95,
106
]
} | {
"id": "C0019046",
"name": "haemoglobins",
"pos": [
144,
156
]
} |
adhesion of calf lens epithelial cells to lens capsule , their natural basement membrane was found to be considerably more rapid than either to plastic or to type i or type iv collagen coated surfaces . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement",
"pos": [
71,
79
]
} | {
"id": "C0009333",
"name": "type iv collagen",
"pos": [
168,
184
]
} |
the data indicate that the antibodies in sera from patients with graves ' disease are directed mainly against a species-unspecific antigen of the plasma membrane from thyroid cells with a probable molecular weight between 4-7 s and are unrelated to thyroglobulin . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
167,
174
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
249,
262
]
} |
rats were pre-treated with propyl-thiouracil ( ptu ) for 3 weeks in order to deplete their thyroids of thyroglobulin . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroids",
"pos": [
91,
99
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
103,
116
]
} |
iodide decreased the incorporation of radioactive leucine into total thyroidal protein and into thyroglobulin by 25 and 35 % respectively . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroidal",
"pos": [
69,
78
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
96,
109
]
} |
the findings suggest that dipy and lasa could have a dual role as modifiers of inflammation : 1 ) the well known role as antiaggregants tending to limit and impede thrombosis , and 2 ) as antagonists to the lymphocyte-mediated ( type iv ) immune reaction through a depressive action on lymphokine production/release and activity . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocyte",
"pos": [
207,
217
]
} | {
"id": "C0024297",
"name": "lymphokine",
"pos": [
286,
296
]
} |
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