text
stringlengths 57
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| relation
stringclasses 125
values | h
dict | t
dict |
|---|---|---|---|
a statistical method for the calculation of conformation is applied to the small protein , basic pancreatic trypsin inhibitor . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
81,
88
]
} | {
"id": "C0003641",
"name": "basic pancreatic trypsin inhibitor",
"pos": [
91,
125
]
} |
thirty-four of the 39 patients with short-duration response to l-dopa experienced a consistent and reproducible sequence of clinical and biochemical events after each dose , characterized by improvement of parkinsonism and a single phase of dystonia occurring during or shortly after the peak of dopa concentration in plasma and during maximal clinical improvement . | NA | {
"id": "C0023570",
"name": "l-dopa",
"pos": [
63,
69
]
} | {
"id": "C0013023",
"name": "dopa",
"pos": [
296,
300
]
} |
it could exist as orthosilic acid , polymeric silicic acid , colloidal silica ( opal ) , dense silica concentrations , or in the form of organically bound derivatives of silicic acid ( silanolates ) . | NA | {
"id": "C0982384",
"name": "colloidal silica",
"pos": [
61,
77
]
} | {
"id": "C0037098",
"name": "silica",
"pos": [
95,
101
]
} |
various hypotheses for the mechanism of regulation of body-weight in human adults have been proposed in the light of the magnitude of the long-term changes in weight actually observed . | NA | {
"id": "C0005910",
"name": "body-weight",
"pos": [
54,
65
]
} | {
"id": "C0005911",
"name": "changes",
"pos": [
148,
155
]
} |
it is felt by most investigators that cochlear hydrops is an early form of meniere 's disease , and over a long period of time these individuals may develop vertigo as a complaint . | NA | {
"id": "C0206586",
"name": "cochlear hydrops",
"pos": [
38,
54
]
} | {
"id": "C0025281",
"name": "meniere 's disease",
"pos": [
75,
93
]
} |
it is suggested to abandon the term `` '' colonic histiocytosis '' '' since it induces a false impression of a disease entity in the clinician ( and may be related falsely e.g . to `` '' histiocytosis x '' '' , and since the clinician may tend to attribute unnecessary importance to this harmless finding . | NA | {
"id": "C0019618",
"name": "histiocytosi",
"pos": [
50,
62
]
} | {
"id": "C0019621",
"name": "`` '' histiocytosi",
"pos": [
181,
199
]
} |
in order to explain the mechanism of resistance within the tetracycline group , the minimal inhibitory concentration of tetracycline hcl was compared with that of doxycycline in the micro dilution test for bacterial collectives of 48 strains each from the groups of gram-negative and gram-positive cocci , resp . | NA | {
"id": "C0039644",
"name": "tetracycline",
"pos": [
59,
71
]
} | {
"id": "C0546879",
"name": "tetracycline hcl",
"pos": [
120,
136
]
} |
on discharge three quarters of the patients with myocardial infarction had developed hypertriglyceridaemia ( hyperlipoproteinaemia type iv or type iib ) . | NA | {
"id": "C0020557",
"name": "hypertriglyceridaemia",
"pos": [
85,
106
]
} | {
"id": "C0020480",
"name": "hyperlipoproteinaemia type iv",
"pos": [
109,
138
]
} |
with protons of about 5.5 mev and a ge ( li ) gamma-ray detector , and with no chemical processing of the samples , ratios of these two radioisotopes can be determined with sufficient precision to allow 48ca tracer studies to be performed with sensitivity at least equivalent to that possible with the common 45ca radioactive tracer . | NA | {
"id": "C0034595",
"name": "radioisotopes",
"pos": [
136,
149
]
} | {
"id": "C0034551",
"name": "radioactive tracer",
"pos": [
314,
332
]
} |
the ambiguities of water absorption by nylon , one of the components of the plastic , and the uncertainty this reflects in the composition of the plastic were evaluated . | NA | {
"id": "C0028736",
"name": "nylon",
"pos": [
39,
44
]
} | {
"id": "C0032167",
"name": "plastic",
"pos": [
146,
153
]
} |
the extent of in vivo transcription of the chromosomal genes on the plasmid and the ribosomal protein mrna fraction of the total cellular rna weer calculated from dna-rna liquid hybridization experiments using both dna and rna excess procedures . | NA | {
"id": "C0035701",
"name": "ribosomal",
"pos": [
84,
93
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
223,
226
]
} |
this brings a further diagnostic criterion to the clinical and endoscopic differences between proctosigmoiditis and proctocolitis ( colitis ulcerosa ) . | NA | {
"id": "C0033247",
"name": "proctocolitis",
"pos": [
116,
129
]
} | {
"id": "C0009319",
"name": "colitis",
"pos": [
132,
139
]
} |
thiamphenicol ( tap ) , similar to chloramphenicol , inhibits in vivo the synthesis of cytochrome oxidase ( cytox ) , which is partially synthesized by the mitochondrion . | NA | {
"id": "C0039854",
"name": "thiamphenicol",
"pos": [
0,
13
]
} | {
"id": "C0008168",
"name": "chloramphenicol",
"pos": [
35,
50
]
} |
49 % of the stimulation-evoked overflow of total consisted of 3h-noradrenaline , 22 % of 3h-3,4-dihydroxyphenyglycol ( dopeg ) , and 9 % of 3h-normetanephrine . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
65,
78
]
} | {
"id": "C0028385",
"name": "normetanephrine",
"pos": [
143,
158
]
} |
separation of 3h-compounds showed that angiotensin ii caused a proportionate increase in stimulation-evoked overflow of 3h-noradrenaline , 3h-dopeg , and 3h-normetanephrine ; | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
123,
136
]
} | {
"id": "C0028385",
"name": "normetanephrine",
"pos": [
157,
172
]
} |
the role played by the extraneuronal system in the disposition of noradrenaline and adrenaline in vessels . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
66,
79
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
84,
94
]
} |
the role played by extraneuronal sites in the disposition of noradrenaline and adrenaline was studied in the saphenous vein and in the mesenteric artery of the dog , taking as parameters the influence of blockade of these sites on the sensitivity to and on the time for half-relaxation ( t50 ) ( both in oil and in krebs solution ) of these agonists . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
61,
74
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
79,
89
]
} |
in low ( 0.023 and 0.23 mum ) or in moderately high ( 2.3 mum ) concentrations , adrenaline is removed preferentially by extraneuronal sites , whereas noradrenaline `` '' preferred '' '' neuronal sites . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
81,
91
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
151,
164
]
} |
both in the veins and in the arteries noradrenaline was inactivated more rapidly than adrenaline . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
38,
51
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
86,
96
]
} |
sialic acid and mucoprotein tyrosine ( mpt ) as two important and sensitive indicators of blood serum glycoprotein changes were used for the dynamic follow up of the tumor growth in humans . | NA | {
"id": "C0026714",
"name": "mucoprotein",
"pos": [
16,
27
]
} | {
"id": "C0017968",
"name": "glycoprotein",
"pos": [
102,
114
]
} |
a disadvantage of the model is the necessity of provoking each seizure separately which causes that this model can not meet one of the conditions of jasper 's definition concerning spontaneity of seizure development . | NA | {
"id": "C0036572",
"name": "seizure",
"pos": [
63,
70
]
} | {
"id": "C0014544",
"name": "conditions",
"pos": [
135,
145
]
} |
from these facts , it is suggested that these aneurysms were not pseudo-aneurysms but sacuular aneurysms . | NA | {
"id": "C1510412",
"name": "pseudo-aneurysms",
"pos": [
65,
81
]
} | {
"id": "C0002940",
"name": "aneurysms",
"pos": [
95,
104
]
} |
the plant lectin concanavalin a appears to stabilize the process of vesicle fusion leading to an aggregation of multilaminate vesicles trapped in the lumen of the surface pits . | NA | {
"id": "C0304052",
"name": "plant",
"pos": [
4,
9
]
} | {
"id": "C0009630",
"name": "concanavalin a",
"pos": [
17,
31
]
} |
the intestinal absorption of glycine , lysine , and phenylalanine were , respectively , decreased 22 , 18 , and 15 % when these amino acids were present at 1 mm levels . | NA | {
"id": "C0017890",
"name": "glycine",
"pos": [
29,
36
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
128,
139
]
} |
since plasma membrane lipids may represent the structural key to enveloping and release of paramyxovirions , the lipid composition of mp and lp cells and purified plasma membranes was investigated . | NA | {
"id": "C0025249",
"name": "plasma membrane lipids",
"pos": [
6,
28
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
113,
118
]
} |
the glycosphingolipid components of heart and liver cells are also the same , as is the content of gangliosides ( 6.18 mug vs. 6.49 mug neuraminic acid/mg protein ) in these cells , but the heart cell contains one-fifth as much total cerebroside ( 34.3 mg vs. 174.3 mug cerebroside/mg protein ) , indicating a greater ganglioside to neutral glycolipid ratio for the heart cell . | NA | {
"id": "C0017978",
"name": "glycosphingolipid",
"pos": [
4,
21
]
} | {
"id": "C0017950",
"name": "glycolipid",
"pos": [
341,
351
]
} |
no significant differences in basal or putrescine-stimulated sam decarboxylase activity were noted between normal fibroblast cultures and cells from patients with cystic fibrosis ( fig . 2 ) . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
114,
124
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
138,
143
]
} |
since beginning this study , the number of cervical cerclages in our department has decreased and we have observed a parallel decrease in premature deliveries , since with the elimination of problems related to the isthmus we have directed our efforts towards other causes of premature labour . | NA | {
"id": "C0151526",
"name": "premature deliveries",
"pos": [
138,
158
]
} | {
"id": "C0022876",
"name": "premature labour",
"pos": [
276,
292
]
} |
thus we have been led to include calibration of the isthmus in routine examinations in pregnancies occurring on the one hand in women with previous infertility as well as in those in which pregnancy follows a period of involuntary sterility . | NA | {
"id": "C0021361",
"name": "women",
"pos": [
128,
133
]
} | {
"id": "C0021359",
"name": "sterility",
"pos": [
231,
240
]
} |
a sensitive new approach for measuring the repair of single strand breaks in dna induced by low doses of gamma irradiation was tested in cultured fibroblasts from chinese hamster lung , human afflicted with ataxia telangiectasia or fanconi 's anemia and in normal cells of early and late passages . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
146,
157
]
} | {
"id": "C0007634",
"name": "normal cells",
"pos": [
257,
269
]
} |
anorexic and behavioural effects of a new imidazo-isoindole derivative ( mazindol ) in comparison with d-amphetamine in the rat . | NA | {
"id": "C1956073",
"name": "isoindole",
"pos": [
50,
59
]
} | {
"id": "C0024977",
"name": "mazindol",
"pos": [
73,
81
]
} |
the effect of an imidazo-isoindole derivative ( mazindol ) upon motor and feeding activity and two different avoidance behaviours have been compared with those of d-amphetamine in rats . | NA | {
"id": "C1956073",
"name": "isoindole",
"pos": [
25,
34
]
} | {
"id": "C0024977",
"name": "mazindol",
"pos": [
48,
56
]
} |
mazindol , like d-amphetamine , caused a stereotyped behaviour in rats when given in very high doses , but the range between the anorexic and the stereotyped behaviour dose is much higher for mazindol than for d-amphetamine . | NA | {
"id": "C0011812",
"name": "d-amphetamine",
"pos": [
16,
29
]
} | {
"id": "C0002658",
"name": "amphetamine",
"pos": [
212,
223
]
} |
the subcellular distribution studies in brains of tolerant and non-tolerant rats indicated that an accelerated shift in the concentrations of delta-9-thc and 11-oh-delta-9-thc towards highly polar metabolites in the brains , rather than an increased elimination of these cannabinoids or decreased sensitivity of the brain may be responsible for the development of tolerance to delta-9-thc . | NA | {
"id": "C0006864",
"name": "cannabinoids",
"pos": [
271,
283
]
} | {
"id": "C0039663",
"name": "thc",
"pos": [
385,
388
]
} |
the methyl xanthines , theophylline , caffeine and 3-isobutyl-1 methyl xanthine ( mix ) inhibited the pressure responses to noradrnealine , angiotensin ii and potassium ions in the isolated perfused mesenteric vascular bed of the male rat . | NA | {
"id": "C0039771",
"name": "theophylline",
"pos": [
23,
35
]
} | {
"id": "C0000096",
"name": "3-isobutyl-1 methyl xanthine",
"pos": [
51,
79
]
} |
mucosal pg levels were higher in gallbladders with multiple gallstones than with a solitary stone , and overall the mean pg level in mucosa was 12-13 times higher than in the muscle wall . | NA | {
"id": "C0008350",
"name": "gallstones",
"pos": [
60,
70
]
} | {
"id": "C0006736",
"name": "stone",
"pos": [
92,
97
]
} |
vasopressin ( antidiuretic hormone , adh ) , release in response to hemorrhage was studied in spontaneously hypertensive rats ( shr ) , kyoto-wistar rats ( kwr ) , and wistar rats ( wr ) . | NA | {
"id": "C0003779",
"name": "vasopressin",
"pos": [
0,
11
]
} | {
"id": "C0042413",
"name": "antidiuretic hormone",
"pos": [
14,
34
]
} |
the rare presence of the ph1 chromosome in chronic myeloproliferative disorders other than chronic granulocytic leukemia ( cgl ) , i.e . polycythemia vera ( pv ) , myeloid metaplasia with myelofibrosis ( mmm ) and hemorrhagic thrombocytopenia ( ht ) raised the question whether or not the ph1 chromosome is peculiar to cgl . | NA | {
"id": "C0023470",
"name": "granulocytic leukemia",
"pos": [
99,
120
]
} | {
"id": "C0023473",
"name": "cgl",
"pos": [
319,
322
]
} |
in addition to the fluoride rinses one of two randomized groups was given three paintings per year with a 0.2 % naf-solution . | NA | {
"id": "C0016327",
"name": "fluoride",
"pos": [
19,
27
]
} | {
"id": "C0037508",
"name": "naf",
"pos": [
112,
115
]
} |
quantitation of these monosaccharides in 37 frozen-stored cyst fluids and autologous sera showed that the average content of hexoses , hexosamine , and sialic acid in cyst fluid approximated that in serum , whereas cyst fluid contained significantly more fucose than did serum . | NA | {
"id": "C0026492",
"name": "monosaccharides",
"pos": [
22,
37
]
} | {
"id": "C0019494",
"name": "hexoses",
"pos": [
125,
132
]
} |
the results of the study indicate that antibodies of all the 5 immunoglobulin classes are probably involved in the defense against the causative microbes in bacterial meningitis . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
39,
49
]
} | {
"id": "C0021017",
"name": "immunoglobulin classes",
"pos": [
63,
85
]
} |
ten children were treated with ampicillin pediatric suspension in a dose of 100 mg ampicillin/kg/24 hours divided in 4 doses , and 6 children with pivampicillin base pediatric suspension in a dose of 64.8 mg/kg/24 hours divided in 4 doses ( approximately 50 mg ampicillin/kg ) . | NA | {
"id": "C0032032",
"name": "pivampicillin",
"pos": [
147,
160
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
261,
271
]
} |
despite the fact that pivampicillin was administered in half of the dosage of ampicillin the resulting peak serum concentration was 65 % higher and was achieved more rapidly . | NA | {
"id": "C0032032",
"name": "pivampicillin",
"pos": [
22,
35
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
78,
88
]
} |
46 reference strains and clinical isolated of actinomyces israelli and 8 strains of arachnia propionica -- the causative microorganisms of actinomycosis in man -- were tested for their in vitro susceptibility to penicillin , sulfaisodimidine , erythromycin , tetracycline , lincomycin , clindamycin , metronidazole and tinidazole by the agar dilution method . | NA | {
"id": "C0023726",
"name": "lincomycin",
"pos": [
274,
284
]
} | {
"id": "C0008947",
"name": "clindamycin",
"pos": [
287,
298
]
} |
due to adverse side-effects associated with clindamycin and lincomycin therapy , erythromycin and tetracycline may be the best alternative drugs to penicillin in the treatment of actinomycosis . | NA | {
"id": "C0008947",
"name": "clindamycin",
"pos": [
44,
55
]
} | {
"id": "C0023726",
"name": "lincomycin",
"pos": [
60,
70
]
} |
nineteen healthy volunteer subjects who regularly administered cocaine to themselves were given placebo and 10 and 25 milligrams of cocaine hydrochloride intravenously and intranasally . | NA | {
"id": "C0009170",
"name": "cocaine",
"pos": [
63,
70
]
} | {
"id": "C0282108",
"name": "cocaine hydrochloride",
"pos": [
132,
153
]
} |
equations for the measurement of the supertwisting of circular dna 's from banding positions in buoyant density gradients containing intercalating dyes have required the use of sv40 dna isolated from virions as a reference dna . | NA | {
"id": "C0012925",
"name": "circular dna 's",
"pos": [
54,
69
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
223,
226
]
} |
these equations are modified to allow the use of any closed circular dna of known superhelix density as a reference dna . | NA | {
"id": "C0012925",
"name": "circular dna",
"pos": [
60,
72
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
116,
119
]
} |
proteases and most glycosidases had no effect on spleen colony formation , whereas treatment with vibrio cholerae neuraminidase reduced colonies by one-half . | NA | {
"id": "C0017976",
"name": "glycosidases",
"pos": [
19,
31
]
} | {
"id": "C0027803",
"name": "neuraminidase",
"pos": [
114,
127
]
} |
during pregnancy either clinically or potentially pathological the use of this examination has been demonstrated whether one considers the pathology of the first trimester or that of the end of pregnancy . | NA | {
"id": "C0032979",
"name": "first trimester",
"pos": [
156,
171
]
} | {
"id": "C0032961",
"name": "pregnancy",
"pos": [
194,
203
]
} |
the use of mechanical ( dormia stone basket ) and chemical ( heparin and sodium cholate ) means to remove gallstones via the cholecystostomy fistula reduces the need for additional surgery ( ie , cholecystectomy ) , which is particularly important in poor-risk elderly patients . | NA | {
"id": "C0006736",
"name": "stone",
"pos": [
31,
36
]
} | {
"id": "C0008350",
"name": "gallstones",
"pos": [
106,
116
]
} |
the incidence of tuberculous mastitis at vanderbilt hospital for the last two decades was 0.025 % of surgically treated breast disease . | NA | {
"id": "C0024894",
"name": "mastitis",
"pos": [
29,
37
]
} | {
"id": "C0006145",
"name": "of",
"pos": [
98,
100
]
} |
it is suggested that , in surgical patients , cystine and tyrosine may become essential amino acids and rises in phenylalanine and methionine indicate transient liver dysfunction . | NA | {
"id": "C0002525",
"name": "essential amino acids",
"pos": [
78,
99
]
} | {
"id": "C0025646",
"name": "methionine",
"pos": [
131,
141
]
} |
only collins ' solution prevented the breakdown of rapidly labeled heterogenous high molecular weight rna and ribosomal precursor rna . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
102,
105
]
} | {
"id": "C0035701",
"name": "ribosomal",
"pos": [
110,
119
]
} |
rat embryos were explanted on day 8 or 9 of pregnancy and cultured for up to 48 hours in serum containing added retinol ( vitamin a ) , retinoic acid ( vitamin a acid ) , or absolute ethanol . | NA | {
"id": "C0042839",
"name": "vitamin a",
"pos": [
122,
131
]
} | {
"id": "C0040845",
"name": "vitamin a",
"pos": [
152,
161
]
} |
although only relatively long treatment courses were teratogenic , the defects that resulted were morphologically similar to those induced with retinoic acid or other vitamin a compounds in other animal orders . | NA | {
"id": "C0040845",
"name": "retinoic acid",
"pos": [
144,
157
]
} | {
"id": "C0042839",
"name": "vitamin a",
"pos": [
167,
176
]
} |
urethan did not cause digital malformations on day-11 limbs but induced syndactyly in day-12 forelimbs and polydactyly in day-12 forelimbs and day-13-fore- and hind limbs . | NA | {
"id": "C0206762",
"name": "malformations",
"pos": [
30,
43
]
} | {
"id": "C0039075",
"name": "syndactyly",
"pos": [
72,
82
]
} |
urethan did not cause digital malformations on day-11 limbs but induced syndactyly in day-12 forelimbs and polydactyly in day-12 forelimbs and day-13-fore- and hind limbs . | NA | {
"id": "C0206762",
"name": "malformations",
"pos": [
30,
43
]
} | {
"id": "C0152427",
"name": "polydactyly",
"pos": [
107,
118
]
} |
collagen-induced aggregation in the aggregometer was similar with or without prior alpha chymotrypsin-digestion of a highly dispersed preparation of fibrillar collagen . | NA | {
"id": "C0009325",
"name": "collagen",
"pos": [
0,
8
]
} | {
"id": "C0969669",
"name": "fibrillar collagen",
"pos": [
149,
167
]
} |
our results have demonstrated that urokinase and streptokinase are plasminogen activators specifically activating the rabbit fibrinolytic system while brinase , trypsin and sn 687 increase the general proteolytic activity in vivo . | NA | {
"id": "C0038418",
"name": "streptokinase",
"pos": [
49,
62
]
} | {
"id": "C0032144",
"name": "plasminogen activators",
"pos": [
67,
89
]
} |
decreased adhesion to fibrillar collagen associated with normal spreading and normal adhesion-induced formation of platelet thrombi was found with blood of patients with von willebrand 's disease and the bernard soulier syndrome , indicating a defect in the initial attachment reaction of platelets with collagen . | NA | {
"id": "C0969669",
"name": "fibrillar collagen",
"pos": [
22,
40
]
} | {
"id": "C0009325",
"name": "collagen",
"pos": [
304,
312
]
} |
subjects with ankylosing spondylitis , sacroiliitis without peripheral polyarthritis , reiter 's disease , reactive arthritis , erosive osteoarthritis , psoriatic arthropathy , systemic lupus erythematosus or arthritis associated with a gastrointestinal involvement were excluded from the study . | NA | {
"id": "C0574960",
"name": "sacroiliitis",
"pos": [
39,
51
]
} | {
"id": "C0003864",
"name": "arthritis",
"pos": [
209,
218
]
} |
the major bile acids of the fetus and newborn rabbit were cholic acid , chenodeoxycholic acid , and deoxycholic acid . | NA | {
"id": "C0008024",
"name": "chenodeoxycholic acid",
"pos": [
72,
93
]
} | {
"id": "C0011479",
"name": "deoxycholic acid",
"pos": [
100,
116
]
} |
we assume infinitesimal concentration of tracer , equilibrium of reactants , perfect separation of bound and free , and that each of the two antisera contain only a single class of antibody sites which can bind to the desired ligand or to a cross-reacting species . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
141,
149
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
181,
189
]
} |
progesterone , 20alpha-dihydroprogesterone , estrone and estradiol-17beta concentrations were estimated by radioimmunoassay in blood plasma from uterine , uteroovarian and femoral veins of rhesus monkeys ( macaca mulatta ) on days 22 , 49 , 128 and 160 of gestation . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
0,
12
]
} | {
"id": "C0012311",
"name": "dihydroprogesterone",
"pos": [
23,
42
]
} |
progesterone/20alpha-dihydroprogesterone was higher in both uterine and uteroovarian than in femoral venous plasma suggesting peripheral metabolism of progesterone to 20alpha-dihydroprogesterone . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
0,
12
]
} | {
"id": "C0012311",
"name": "dihydroprogesterone",
"pos": [
175,
194
]
} |
postoperative bleeding was seen two times more often in the heparin group , but bleeding was not severe and was easily controlled . | NA | {
"id": "C0032788",
"name": "postoperative bleeding",
"pos": [
0,
22
]
} | {
"id": "C0019080",
"name": "bleeding",
"pos": [
80,
88
]
} |
angiograms following renal trauma in a ten-year-old girl were highly suggestive of renal neoplasm , especially wilms ' tumor . | NA | {
"id": "C0022665",
"name": "renal neoplasm",
"pos": [
83,
97
]
} | {
"id": "C0027708",
"name": "wilms",
"pos": [
111,
116
]
} |
there was no evidence for congenital or acquired cardiac defects , cardiomyopathy or myocarditis in either of them . | NA | {
"id": "C0878544",
"name": "cardiomyopathy",
"pos": [
67,
81
]
} | {
"id": "C0027059",
"name": "myocarditis",
"pos": [
85,
96
]
} |
thus in addition to the well known changes of lung function occuring in rheumatoid arthritis , progressing fibrosis might also contribute to a more extensive impairment of the lung function in ss . | NA | {
"id": "C0003873",
"name": "rheumatoid arthritis",
"pos": [
72,
92
]
} | {
"id": "C1527336",
"name": "ss",
"pos": [
193,
195
]
} |
[ characteristics of strains of the agents of pseudotuberculosis and intestinal yersiniosis isolated from several species of domestic animals ] . | NA | {
"id": "C0043410",
"name": "pseudotuberculosis",
"pos": [
46,
64
]
} | {
"id": "C0043407",
"name": "yersiniosis",
"pos": [
80,
91
]
} |
the test of indirect degranulation of rat mast cells was applied to the study of the specific activity of 16 series of noninfectious allergens from domestic dust ( 3 series ) from hotel dust ( 7 series ) and from the pollen of fescue ( 6 series ) . | NA | {
"id": "C0002092",
"name": "allergens",
"pos": [
133,
142
]
} | {
"id": "C0524581",
"name": "domestic dust",
"pos": [
148,
161
]
} |
in studying the specific activity of domestic allergens use was made of the sera of patients suffering from bronchial asthma with a marked allergy to domestic dust sera of patients with pollinoses with a marked allergy to fescue pollen was applied to the study of the specific activity of pollen allergen . | NA | {
"id": "C0002092",
"name": "allergens",
"pos": [
46,
55
]
} | {
"id": "C0524581",
"name": "domestic dust",
"pos": [
150,
163
]
} |
in studying the specific activity of domestic allergens use was made of the sera of patients suffering from bronchial asthma with a marked allergy to domestic dust sera of patients with pollinoses with a marked allergy to fescue pollen was applied to the study of the specific activity of pollen allergen . | NA | {
"id": "C0002092",
"name": "allergens",
"pos": [
46,
55
]
} | {
"id": "C1320238",
"name": "pollen allergen",
"pos": [
289,
304
]
} |
all these leghemoglobins have similar affinities for the small anionic ligand fluoride ion , and they are only slightly more accessible to this ligand than is sperm whale myoglobin . | NA | {
"id": "C0003075",
"name": "anionic",
"pos": [
63,
70
]
} | {
"id": "C0016327",
"name": "fluoride ion",
"pos": [
78,
90
]
} |
the steroidogenic and lipolytic activities of corticotrophin- ( 1-24 ) -tetracosapeptide and [ lys17,18 ] corticotrophin- ( 1-18 ) -octadecapeptide amide were compared with those of corresponding analogues substituted in position 8 with norarginine and homoarginine , and in position 9 with phenylalanine and pentamethylphenylalanine . | NA | {
"id": "C0010192",
"name": "tetracosapeptide",
"pos": [
72,
88
]
} | {
"id": "C0001655",
"name": "corticotrophin",
"pos": [
106,
120
]
} |
conventional ( conv ) rats were fed by stomach tube for five days with either benzylpenicillin , ampicillin , tetracykline , oxitetracykline , neomycin , bacitracin + neomycin , kanamycin or colistin . | NA | {
"id": "C0030827",
"name": "benzylpenicillin",
"pos": [
78,
94
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
97,
107
]
} |
venous blood samples were drawn 2 , 3 , 4 , 5 and 6 hours after the injection of diazepam for measurement of the serum levels of total and free ( unbound ) diazepam , n-desmethyldiazepam , and free fatty acids . | NA | {
"id": "C0012010",
"name": "diazepam",
"pos": [
81,
89
]
} | {
"id": "C0011279",
"name": "desmethyldiazepam",
"pos": [
169,
186
]
} |
biochemical effects of baclofen ( beta-parachlorophenyl-gaba ) on the dopamine and the noradrenaline in the rat brain . | NA | {
"id": "C0004609",
"name": "baclofen",
"pos": [
23,
31
]
} | {
"id": "C0016904",
"name": "gaba",
"pos": [
56,
60
]
} |
baclofen ( beta-parachlorophenyl-gaba ) caused an increase in the concentration of dopamine in the rat brain with a maximum of about 170 % of the control value after 1 hr and after doses of 50 mg/kg or more intraperitoneally . | NA | {
"id": "C0004609",
"name": "baclofen",
"pos": [
0,
8
]
} | {
"id": "C0016904",
"name": "gaba",
"pos": [
33,
37
]
} |
hence , baclofen might also interrupt the nerve impulse flow in central dopamine neurones , perhaps by stimulating a central gaba mechanism . | NA | {
"id": "C0004609",
"name": "baclofen",
"pos": [
8,
16
]
} | {
"id": "C0016904",
"name": "gaba",
"pos": [
125,
129
]
} |
various practical procedures are given for extracting and derivatizing compounds , such as carboxylic acids , hydroxy acids , alcohols , amines , and nitrosamines . | NA | {
"id": "C0007066",
"name": "carboxylic acids",
"pos": [
91,
107
]
} | {
"id": "C0020317",
"name": "hydroxy acids",
"pos": [
110,
123
]
} |
forty-two patients with cardiogenic shock ( cs ) secondary to myocardial infarction were treated with intra-aortic balloon pumping ( i.a.b.p . ) . | NA | {
"id": "C0036980",
"name": "cardiogenic shock",
"pos": [
24,
41
]
} | {
"id": "C0027051",
"name": "myocardial",
"pos": [
62,
72
]
} |
the differences between infarction caused by permanent ischemia and the evolution of infarction following reperfusion were studied by means of histologic ( 121 specimens ) histoenzymatic ( 56 specimens ) , ecg ( 100 specimens ) , techniques and study of the mcirocirculation ( 70 specimens ) . | NA | {
"id": "C0022116",
"name": "ischemia",
"pos": [
55,
63
]
} | {
"id": "C0021308",
"name": "infarction",
"pos": [
85,
95
]
} |
the size of the infarctions caused by temporary ischemia was found to be significantly smaller in 60 % of the cases as compared to the infarctions caused by permanent ischemia . | NA | {
"id": "C0021308",
"name": "infarctions",
"pos": [
16,
27
]
} | {
"id": "C0022116",
"name": "ischemia",
"pos": [
167,
175
]
} |
because of previous reports of the beneficial effect of vitamin e in angina pectoris patients , 48 patients , with both stable angina and positive ( chest pain plus ishemic st depression ) maximal exercise treadmill tests , participated in a double-blind cross-over study of 6 months of vitamin e and 6 months of placebo therapy , separated by a 2 month no treatment period . | NA | {
"id": "C0002962",
"name": "angina",
"pos": [
69,
75
]
} | {
"id": "C0340288",
"name": "stable angina",
"pos": [
120,
133
]
} |
preoperatively , systolic wall motion of the region from which the biopsy specimen was taken was semiquantitatively graded as showing normal motion , hypokinesia , akinesia or dyskinesia on ventriculography . | NA | {
"id": "C0086439",
"name": "hypokinesia",
"pos": [
150,
161
]
} | {
"id": "C0013384",
"name": "dyskinesia",
"pos": [
176,
186
]
} |
arrhythmias documented by 24 hour continuous electrocardiographic monitoring in 50 male medical students without apparent heart disease . | NA | {
"id": "C0003811",
"name": "arrhythmias",
"pos": [
0,
11
]
} | {
"id": "C0018799",
"name": "heart disease",
"pos": [
122,
135
]
} |
the improvement in nitrogen balance resulting from the addition of urea to a plant protein source suggested that urea may be used to partially supply the protein needs of growing boys . | NA | {
"id": "C0032089",
"name": "plant protein",
"pos": [
77,
90
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
154,
161
]
} |
basic morphologic criteria for proper differentiation of malignant immunoblastic problems , lymphoma , and hodgkin 's disease are discussed . | NA | {
"id": "C0024299",
"name": "lymphoma",
"pos": [
92,
100
]
} | {
"id": "C0019829",
"name": "hodgkin 's disease",
"pos": [
107,
125
]
} |
the eight protein fractions studied : albumin , alpha-1 antitrypsin , alpha-2 macroglobulin , haptoglobin , beta-lipoprotein , c3 complement , and gamma globulin , correlated very well with the corresponding components in the various methods used . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
10,
17
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
38,
45
]
} |
results obtained with stools preserved in a simple , stable and relatively nontoxic fixative ( saf ) composed of sodium acetate , acetic acid and formalin , suggest that this fixative is a suitable alternative to other fixatives for the preservation and recovery of intestinal parasites by diphasic concentration methods and permanent staining . | NA | {
"id": "C0142785",
"name": "sodium acetate",
"pos": [
113,
127
]
} | {
"id": "C0000983",
"name": "acetic acid",
"pos": [
130,
141
]
} |
forty-one epileptic children , aged 2 to 16 years , receiving combinations of phenobarbital , phenytoin , and primidone , and 39 control children were studied . | NA | {
"id": "C0031412",
"name": "phenobarbital",
"pos": [
78,
91
]
} | {
"id": "C0033148",
"name": "primidone",
"pos": [
110,
119
]
} |
this case demonstrates that encephalopathy in reye syndrome can develop prior to detectable hepatic involvement , and suggests that factors unrelated to generalized liver damage may occasionally play a role in the pathogenesis of this obscure disorder . | NA | {
"id": "C0039082",
"name": "syndrome",
"pos": [
51,
59
]
} | {
"id": "C0012634",
"name": "disorder",
"pos": [
243,
251
]
} |
the remaining 11 amniotic fluids did not contain the peptide component of the phosphate-sensitive bacterial inhibitor and could not be made inhibitory by adjusting the phosphate to zinc ratio to less than 200 mug per milliliter . | NA | {
"id": "C0031603",
"name": "phosphate",
"pos": [
78,
87
]
} | {
"id": "C0078788",
"name": "phosphate",
"pos": [
168,
177
]
} |
the most common presenting signs were dyspnea and/or thromboembolism , systolic murmurs with gallop rhythms on auscultation , cardiomegaly with ( group a ) or without ( group b ) pulmonary edema , abnormal electrocardiograms , elevated left ventricular end diastolic pressures , and angiocardiographic evidence of mitral regurgitation with left ventricular concentric hypertrophy ( group a ) or left ventricular dilatation ( group b ) . | NA | {
"id": "C0018800",
"name": "cardiomegaly",
"pos": [
126,
138
]
} | {
"id": "C0149721",
"name": "left ventricular",
"pos": [
395,
411
]
} |
plasmin or a crude collagenase released large amounts of lipoprotein from samples of amorphous atheroma lipid . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
57,
68
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
104,
109
]
} |
turnover rates of blood glucose and lactate , along with the rates of their interconversion , were calculated from changes of their specific activities in rats infused with [ u-14c ] glucose and [ u-14c ] lactate based on a simple flux model of the cori cycle . | NA | {
"id": "C0005802",
"name": "blood glucose",
"pos": [
18,
31
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
183,
190
]
} |
insulin-induced stimulation of blood glucose removal was associated with increased glucose production , whereas anti-insulin serum-induced stimulation of glucose production was associated with increased glucose removal . | NA | {
"id": "C0005802",
"name": "blood glucose",
"pos": [
31,
44
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
203,
210
]
} |
the present study was undertaken to test the possibility that the angiotensinogen response to angiotensin is mediated via an increase in glucocorticoid secretion . | NA | {
"id": "C0003017",
"name": "angiotensinogen",
"pos": [
66,
81
]
} | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
94,
105
]
} |
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