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stringlengths 57
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stringclasses 125
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dict |
|---|---|---|---|
the beta-adrenergic agonist inhibited the accumulation of alanine , threonine , phenylalanine , tyrosine , lysine , arginine , leucine , and valine and increased the loss of glutamate , aspartate , serine , and isoleucine from the pool of free amino acids in perfusate and muscle . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
58,
65
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
244,
255
]
} |
in addition to an effect on degradation , it appeared that isoproterenol affected amino acid levels by increasing alanine utilization and causing formation of glutamine instead of alanine . | NA | {
"id": "C0002520",
"name": "amino",
"pos": [
82,
87
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
180,
187
]
} |
plasma and urinary norepinephrine ( ne ) and epinephrine ( e ) decreased following both saline ( urinary ) ne+e , from 17.3 +/- 3.4 to 6.8 +/- 1.5 ng/min ; | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
22,
33
]
} | {
"id": "C0028351",
"name": "ne",
"pos": [
107,
109
]
} |
comparison of our data with the reported cardiovascular adjustments and blood concentration of gastrointestinal hormones following a meal suggests that cholecystokinin may contribute to postprandial intestinal hyperemia . | NA | {
"id": "C0017182",
"name": "gastrointestinal",
"pos": [
95,
111
]
} | {
"id": "C0008328",
"name": "cholecystokinin",
"pos": [
152,
167
]
} |
parenteral evans blue dye ( ebd ) binds to albumin and thus can indicate transvascular protein flux . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
43,
50
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
87,
94
]
} |
tachyphylaxis to [ ile5 ] angiotensin ii ( angiotensin ) in the isolated guinea pig ileum was found to be more severe when the ca2+ concentration or the temperature of the medium were lowered , or when glucose was absent . | NA | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
26,
40
]
} | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
43,
54
]
} |
phospholipid synthesis for new membrane formation in regenerating cells was studied by using [ 14c ] choline as a precursor of phosphorylcholine and cytidine diphosphocholine ( cdp-choline ) , which are intermediates in the synthesis of renal choline-containing phospholipid . | NA | {
"id": "C0008405",
"name": "choline",
"pos": [
101,
108
]
} | {
"id": "C0031716",
"name": "phosphorylcholine",
"pos": [
127,
144
]
} |
phospholipid synthesis for new membrane formation in regenerating cells was studied by using [ 14c ] choline as a precursor of phosphorylcholine and cytidine diphosphocholine ( cdp-choline ) , which are intermediates in the synthesis of renal choline-containing phospholipid . | NA | {
"id": "C0008405",
"name": "choline",
"pos": [
101,
108
]
} | {
"id": "C0010725",
"name": "cdp-choline",
"pos": [
177,
188
]
} |
the entire increment in choline radioactivity in regenerating tissue 2 and 3 days after mercury administration was in phospholipid or cdp-choline , which suggests that the increased number of choline molecules entering the growing cells were trapped in these two forms . | NA | {
"id": "C0008405",
"name": "choline",
"pos": [
24,
31
]
} | {
"id": "C0010725",
"name": "cdp-choline",
"pos": [
134,
145
]
} |
tissue levels of total carnitine and long-chain acylcarnitine derivatives were greatly reduced in the older heart without significant change in free coa , acetyl-coa , or long-chain acyl-coa . | NA | {
"id": "C0001026",
"name": "acetyl-coa",
"pos": [
155,
165
]
} | {
"id": "C0001374",
"name": "long-chain acyl-coa",
"pos": [
171,
190
]
} |
the authors hypothesize that the reason for this gender-specific difference in distress levels of invested partners is society 's definition of the male 's role as the responsibe partner regarding satisfaction in sexual relationships . | NA | {
"id": "C0079399",
"name": "gender",
"pos": [
49,
55
]
} | {
"id": "C0086582",
"name": "male 's",
"pos": [
148,
155
]
} |
in 22 lepromatous filipino patients receiving their first injection of 225 mg acedapsone ( dadds ) , dapsone ( dds ) , and monoacetyl dds ( madds ) were present in plasma in approximately equal quantities . | NA | {
"id": "C0000949",
"name": "dadds",
"pos": [
91,
96
]
} | {
"id": "C0010980",
"name": "dapsone",
"pos": [
101,
108
]
} |
to determine whether a low preference for human blood by triatoma dimidiata maculipennis stal , 1859 , the only known vector of chagas ' disease in yucatan , mexico , would account for the low prevalence of antibodies to trypanosoma cruzi in man in the area , the intestinal contents of 924 bugs were tested against antisera to blood antigens of chicken , opossum , dog , bat , monkey , pig , goat , rabbit , horse , human , rat , ox , cat , and armadillo . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
207,
217
]
} | {
"id": "C0020960",
"name": "antisera",
"pos": [
316,
324
]
} |
while in the group of the healthy persons the following amino - acids proved to have significantly higher values : alpha -- aminobutter-acid , glycine and cystine . | NA | {
"id": "C0002520",
"name": "amino",
"pos": [
56,
61
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
143,
150
]
} |
before and during the period of hypotension , the following were measured : mean arterial blood pressure , cardiac output , whole-body o2 consumption , cerebral blood flow , cerebral o2 consumption , arterial blood gases , blood o2 content , and lactate , pyruvate , glucose , epinephrine , and norepinephrine concentrations . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
277,
288
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
295,
309
]
} |
this technique can be coupled with specific assays for ionized forms of the cations or with ion electrodes to obtain values for protein-bound , ionized , or complexed and chelated ca and mg in equine serum . | NA | {
"id": "C0007447",
"name": "cations",
"pos": [
76,
83
]
} | {
"id": "C0022023",
"name": "ion",
"pos": [
144,
147
]
} |
a two month old boy with multiple malformations : mental retardation , microcephaly , hyperterloism , displasic ears , hypospadias , unilateral cryptorchidism and holoprosencephaly is presented . | NA | {
"id": "C0000772",
"name": "multiple malformations",
"pos": [
25,
47
]
} | {
"id": "C0079541",
"name": "holoprosencephaly",
"pos": [
163,
180
]
} |
this has been related to the retention of chloride and bicarbonate anions to offset the cationic charge of the monoclonal immunoglobulins . | NA | {
"id": "C0008203",
"name": "chloride",
"pos": [
42,
50
]
} | {
"id": "C0003075",
"name": "anions",
"pos": [
67,
73
]
} |
the combination is probably the treatment of choice in cryptococcal meningitis and offers promise in the therapy of systemic candidiasis and nonmeningeal cryptococcosis . | NA | {
"id": "C0085436",
"name": "cryptococcal meningitis",
"pos": [
55,
78
]
} | {
"id": "C0010414",
"name": "cryptococcosis",
"pos": [
154,
168
]
} |
this 36-year-old white man developed signs and symptoms of mild reversible papillophlebitis associated with calf thrombophlebitis and subsequent mammary and antecubital vein phlebitis after fluorescein angiography . | NA | {
"id": "C0040046",
"name": "thrombophlebitis",
"pos": [
113,
129
]
} | {
"id": "C0031542",
"name": "phlebitis",
"pos": [
174,
183
]
} |
humans exposed to simulated depths of up to 305 meters without barotrauma or decompression sickness develop transient , conductive hearing losses with no audiometric evidence of cochlear dysfunction . | NA | {
"id": "C0004760",
"name": "barotrauma",
"pos": [
63,
73
]
} | {
"id": "C0011119",
"name": "decompression sickness",
"pos": [
77,
99
]
} |
[ biosynthesis of rubomycin . the glycosylation of exogenous rubomycin one and carminomycin one by a rubomycin-producing culture ] . | NA | {
"id": "C0007308",
"name": "carminomycin",
"pos": [
79,
91
]
} | {
"id": "C0011015",
"name": "rubomycin",
"pos": [
101,
110
]
} |
benzylpenicillin ( 90.8 per cent of the sensitive strains ) , ampicillin ( 67.1 per cent ) , tetracycline ( 66.7 per cent ) , levomycetin ( 68.6 per cent ) and streptomycin ( 38.1 per cent ) were less effective . | NA | {
"id": "C0030827",
"name": "benzylpenicillin",
"pos": [
0,
16
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
62,
72
]
} |
the treatment of massive or persistent hemobilia is surgical drainage of hematoma and ligation of bleeding sites . | NA | {
"id": "C0018944",
"name": "hematoma",
"pos": [
73,
81
]
} | {
"id": "C0019080",
"name": "bleeding",
"pos": [
98,
106
]
} |
cell-free extracts also contained activities of fructose-1,6-p2 aldolase , fructose-1,6-p2 phosphatase , and p-hexose isomerase which could convert fructose-1,6-p2 to intermediates of either the embden-meyerhof pathway or entner-doudoroff pathway . | NA | {
"id": "C0019494",
"name": "hexose",
"pos": [
111,
117
]
} | {
"id": "C0016745",
"name": "fructose",
"pos": [
148,
156
]
} |
plasma levels of imipramine and its metabolite desipramine hydrochloride ( desmethylimipramine ) were measured three times weekly and the relationship between plasma steady-state levels and clinical outcome was examined . | NA | {
"id": "C0700529",
"name": "desipramine hydrochloride",
"pos": [
47,
72
]
} | {
"id": "C0011685",
"name": "desmethylimipramine",
"pos": [
75,
94
]
} |
this study describes the occurrence and frequency of affective disorders and evaluates the relative usefulness of three separate sets of diagnostic criteria for the depressive phase of the illness , which are considered in three self-evident , mutually exclusive groups , the definition of which depends on chronology of onset in relation to other diagnoses . | NA | {
"id": "C0525045",
"name": "affective disorders",
"pos": [
53,
72
]
} | {
"id": "C0011581",
"name": "depressive",
"pos": [
165,
175
]
} |
we report the ninth documentated coincidence of anorexia nervosa and xo gonadel dysgenesis ( turner syndrome ) and the second confirmed coincidence of anorexia nervosa and xo/xx ( mosaic ) gonadal dysgenesis . | NA | {
"id": "C0041408",
"name": "turner syndrome",
"pos": [
93,
108
]
} | {
"id": "C0018051",
"name": "gonadal dysgenesis",
"pos": [
189,
207
]
} |
one hundred twenty-seven successfully methadone-hydrochloride-maintained patients were randomly assigned to one of the following four groups and studied for 30 weeks : ( 1 ) known maintenance-patients were maintained on methadone under open conditions ; | NA | {
"id": "C0721688",
"name": "methadone-hydrochloride",
"pos": [
38,
61
]
} | {
"id": "C0025605",
"name": "methadone",
"pos": [
220,
229
]
} |
muscle stiffness and spasm are decreased by the gaba derivative baclofen as well as by clonacepam , which is preferable to diazepam because of less intense sedation . | NA | {
"id": "C0016904",
"name": "gaba",
"pos": [
48,
52
]
} | {
"id": "C0004609",
"name": "baclofen",
"pos": [
64,
72
]
} |
a case of an intrathecal herniation of a cervical disc with transitory paraplegia and a following brown-sequard-syndrome is reported . | NA | {
"id": "C0030486",
"name": "paraplegia",
"pos": [
71,
81
]
} | {
"id": "C0242644",
"name": "brown-sequard-syndrome",
"pos": [
98,
120
]
} |
the ankylosed spine may be fractured following relatively mild trauma attributable to loss of flexibility and increased fragility from osteoporosis . | NA | {
"id": "C0016658",
"name": "fractured",
"pos": [
27,
36
]
} | {
"id": "C0043251",
"name": "trauma",
"pos": [
63,
69
]
} |
ha of h. gallinarum was heat-labile and inactivated by formalin , ethanol , methanol , and ethyl acetate . | NA | {
"id": "C0001962",
"name": "ethanol",
"pos": [
66,
73
]
} | {
"id": "C0001963",
"name": "methanol",
"pos": [
76,
84
]
} |
the cell line has surface antigens typical of chicken thymus cells ( t cells ) and histocompatability antigens different from those of the host chicken . | NA | {
"id": "C0003339",
"name": "surface antigens",
"pos": [
18,
34
]
} | {
"id": "C0019628",
"name": "histocompatability antigens",
"pos": [
83,
110
]
} |
generation of electronically excited aromatic aldehydes in the peroxidase catalyzed aerobic oxidation of aromatic acetaldehydes . | NA | {
"id": "C0001992",
"name": "aldehydes",
"pos": [
46,
55
]
} | {
"id": "C0000966",
"name": "acetaldehydes",
"pos": [
114,
127
]
} |
indequate handling of the vaccine or combination of vaccine withe gammaglobulin used in 1969 and 1970 , are also mentioned as a possibility to explain failures of the vaccine in ths group of well vaccinated children . | NA | {
"id": "C0206253",
"name": "combination",
"pos": [
37,
48
]
} | {
"id": "C0042210",
"name": "vaccine",
"pos": [
167,
174
]
} |
the absorption of oral [ 14c ] -bumetanide was rapid ( absorption half-life 0.61 h ) and complete with a urinary recovery of about 80 % of the intravenous or oral dose during 48 h . | NA | {
"id": "C0000854",
"name": "absorption",
"pos": [
4,
14
]
} | {
"id": "C1373172",
"name": "absorption half-life",
"pos": [
55,
75
]
} |
nordiazepam was shown to be an important metabolite of both medazepam and diazepam : the ratio of medazepam to noradiazepam was 0.14 and the ratio of diazepam to nordiazepam following diazepam administration was 0.72 . | NA | {
"id": "C0011279",
"name": "nordiazepam",
"pos": [
0,
11
]
} | {
"id": "C0012010",
"name": "diazepam",
"pos": [
184,
192
]
} |
it is suggested that in these disorders , melanocytes react morphologically in a similar non-specific manner , whatever the prime pathological process . | NA | {
"id": "C0012634",
"name": "disorders",
"pos": [
30,
39
]
} | {
"id": "C0030660",
"name": "pathological process",
"pos": [
130,
150
]
} |
the method used to obtain amniotic fluid greatly influenced the levels of prostaglandins : fluid obtained by vaginal amniotomy contained significantly higher levels of both pgf and pgfm than samples taken at amniocentesis , reflecting an increase in synthesis and/or release of prostaglandin rather than a decrease in the rate of metabolism . | NA | {
"id": "C0033561",
"name": "pgf",
"pos": [
173,
176
]
} | {
"id": "C0033554",
"name": "prostaglandin",
"pos": [
278,
291
]
} |
the reliability of eight methods for estimating gestational age in the third trimester of pregnancy has been assessed in patients with fetuses of known maturity . | NA | {
"id": "C0032981",
"name": "gestational",
"pos": [
48,
59
]
} | {
"id": "C0032961",
"name": "pregnancy",
"pos": [
90,
99
]
} |
the plasma amino acid concentrations and ratios showed a specific fall in branched-chain amino acids . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
11,
21
]
} | {
"id": "C0002521",
"name": "branched-chain",
"pos": [
74,
88
]
} |
comparison of individual indispensable amino acids absorbed from the intestine with output in milk indicated that methionine was probably the first limiting amino acid . | NA | {
"id": "C0002525",
"name": "indispensable amino acids",
"pos": [
25,
50
]
} | {
"id": "C0025646",
"name": "methionine",
"pos": [
114,
124
]
} |
in contrast , the dissociation constant for the enzyme-mnatp complex is approximately fourfold lower than that for enzyme-atp , and there are no substantial changes in the electron paramagnetic resonance spectrum of mnatp2- when the complex is bound to phosphoglycerate kinase . | NA | {
"id": "C0026741",
"name": "enzyme",
"pos": [
48,
54
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
115,
121
]
} |
the use of the fluorescent fatty acid , parinaric acid ( 9 , 11 , 13 , 15-octadecatetraenoic acid ) ( pna ) , was studied in cells of an unsaturated fatty acid auxotroph of escherichia coli . | NA | {
"id": "C0015684",
"name": "fatty acid",
"pos": [
27,
37
]
} | {
"id": "C0015690",
"name": "unsaturated fatty",
"pos": [
137,
154
]
} |
in the copper-containing protein , almost independent of the copper ion oxidation , the fluorescence quantum yield is approximately 60 % of that of the apoprotein . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
25,
32
]
} | {
"id": "C0003601",
"name": "apoprotein",
"pos": [
152,
162
]
} |
derivatives of the furocoumarin , psoralen , can penetrate intact cells or nuclei and cross-link opposite strands of the chromosomal dna under the influence of long wave-length ultraviolet light . | NA | {
"id": "C0016859",
"name": "furocoumarin",
"pos": [
19,
31
]
} | {
"id": "C0016072",
"name": "psoralen",
"pos": [
34,
42
]
} |
evidence was obtained for the presence of multiple nucleoside adducts of guanosine , adenosine , cytidine , deoxyguanosine , deoxyadenosine , and deoxycytidine . | NA | {
"id": "C0010715",
"name": "cytidine",
"pos": [
97,
105
]
} | {
"id": "C0011485",
"name": "deoxycytidine",
"pos": [
146,
159
]
} |
the small internal pool feeding glycoprotein fucose to the plasma membrane does so at the rate of 8.6 nmol/10 ( 7 ) cells per generation , 4.2 nmol per generation of which , after mixing with the plasma membrane glycoprotein fucose , is ultimately released into the growth medium , 75-80 % as free frucose . | NA | {
"id": "C0025248",
"name": "glycoprotein",
"pos": [
32,
44
]
} | {
"id": "C0017968",
"name": "glycoprotein",
"pos": [
212,
224
]
} |
this change occurs only in medium containing a permeant anion such as chloride and is abolished by an uncoupler of oxidative phosphorylation . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
56,
61
]
} | {
"id": "C0008203",
"name": "chloride",
"pos": [
70,
78
]
} |
a novel strategy for the sequence analysis of oligodeoxyribonucleotides has been devised which is based upon the analysis of intact underivatized oligonucleotides by mass spectrometry followed by interpretation of the mass-spectral data by computerized pattern-recognition techniques . | NA | {
"id": "C0028948",
"name": "oligodeoxyribonucleotides",
"pos": [
46,
71
]
} | {
"id": "C0028953",
"name": "oligonucleotides",
"pos": [
146,
162
]
} |
the synthesis of phospholipids containing unsaturated fatty acids is inhibited at the level of incorporation of the fatty acids into phospholipids . | NA | {
"id": "C0015690",
"name": "unsaturated fatty acids",
"pos": [
42,
65
]
} | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
116,
127
]
} |
the inactivation reaction with glycerol as the inactivator exhibits a deuterium isotope effect of 14 , strongly implicating hydrogen transfer as an important step in the mechanism of inactivation . | NA | {
"id": "C0011744",
"name": "deuterium",
"pos": [
70,
79
]
} | {
"id": "C0020275",
"name": "hydrogen",
"pos": [
124,
132
]
} |
under optimum conditions ( ph 7.5 , mg2+ present ) , the carbon isotope effect is k12/k13 = 0.9989 +/- 0.0004 for the carboxyl carbon undergoing decarboxylation and hydrogen isotope effects are vmaxh/vmaxd = 1.09 +/- 0.04 and ( vmax/km ) h/ ( vmax/km ) d = 0.76 +/- 0.12 with threo-d , l- [ 2-2h ] isocitric acid . | NA | {
"id": "C0007017",
"name": "carbon isotope",
"pos": [
57,
71
]
} | {
"id": "C0022262",
"name": "isotope",
"pos": [
174,
181
]
} |
the carbon isotope effect in the presence of ni2+ at ph 7.5 is k12/k13 = 1.0051 +/- 0.0012 and the hydrogen isotope effects are vmaxh/vmaxd = 0.98 +/- 0.07 and ( vmax/km ) h/ ( vmax/km ) d = 1.11 +/- 0.14 . | NA | {
"id": "C0007017",
"name": "carbon isotope",
"pos": [
4,
18
]
} | {
"id": "C0022262",
"name": "isotope",
"pos": [
108,
115
]
} |
the base-sequence complexities of polysomal poly ( a ) + rna , nuclear poly ( a ) + rna , and total nuclear rna from friend erythroleukemia cells in logarithmic phase of growth were determined by measuring the proportion of labeled unique mouse dna sequences which formed hybrids when incubated with a vast excess of each rna . | NA | {
"id": "C0035700",
"name": "nuclear rna",
"pos": [
100,
111
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
322,
325
]
} |
when the aromatic ring was naphthalene , the modified cytidine occupied the 3'-terminal position , and , when the purine was adenine , the effect was enhanced . | NA | {
"id": "C0034140",
"name": "purine",
"pos": [
114,
120
]
} | {
"id": "C0001407",
"name": "adenine",
"pos": [
125,
132
]
} |
spin-spin exchange was reduced or eliminated in spin-labeled peptidoglycan by the random reduction of free radicals by ascorbate . | NA | {
"id": "C0037914",
"name": "spin-labeled",
"pos": [
48,
60
]
} | {
"id": "C0016693",
"name": "free radicals",
"pos": [
102,
115
]
} |
complexation of spin-labeled peptidoglycan with vancomycin resulted in both pronounced free-radical immobilization and a decrease in spin-spin exchange . | NA | {
"id": "C0037914",
"name": "spin-labeled",
"pos": [
16,
28
]
} | {
"id": "C0016693",
"name": "free-radical",
"pos": [
87,
99
]
} |
the binding of the substrate phosphoenolpyruvate to free enzyme and the enzyme-mn2+ complex was , by necessity , measured by different methods . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
57,
63
]
} | {
"id": "C0026741",
"name": "enzyme",
"pos": [
72,
78
]
} |
the free energy of phosphoenolpyruvate binding to free enzyme ( ks = 1.58 +/- 0.10 x 10 ( -4 ) m ; deltaf degrees = -5.13 +/- 0.04 kcal/mol ) and to the enzyme-mn2+ complex ( k3 = 0.75 +/- 0.10 x 10 ( -6 ) m ; deltaf degrees = -8.26 +/- 0.07 kcal/mol ) also gives a large negative free energy of coupling , delta ( deltaf degrees ) = -3.16 +/- 0.08 kcal/mol . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
55,
61
]
} | {
"id": "C0026741",
"name": "enzyme",
"pos": [
153,
159
]
} |
high concentrations of the enzyme preparation degrade untreated single-stranded dna , but not ultraviolet ( uv ) irradiated dna or dna treated with methylmethanesulfonate or 7-bromomethyl-12-methylbenz [ a ] -anthracene . | NA | {
"id": "C0012935",
"name": "single-stranded dna",
"pos": [
64,
83
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
131,
134
]
} |
the glycoprotein was shown to be homogeneous by electrophoresis , sedimentation equilibrium , and n-terminal group determination , and to contain 19 % protein , 19 % d-galactose , 18 % n-acetyl-d-galactosamine , 15 % n-acetyl-d-glucosamine , 11 % l-fucose , 10 % sialic acid , and 1 % sulfate groups , corresponding to about 1800 amino acid residues and 400 carbohydrate side chains of about 9 monosaccharides . | NA | {
"id": "C0007004",
"name": "carbohydrate",
"pos": [
358,
370
]
} | {
"id": "C0026492",
"name": "monosaccharides",
"pos": [
394,
409
]
} |
analysis of the glucose effect before rna inhibition showed that the hexose interfered with the transcription of dna into invertase messenger rna . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
38,
41
]
} | {
"id": "C0035696",
"name": "messenger rna",
"pos": [
132,
145
]
} |
invertase activity was independent of glucose suggesting that the hexose produces no catabolite inhibition of invertase activity . | NA | {
"id": "C0017725",
"name": "glucose",
"pos": [
38,
45
]
} | {
"id": "C0019494",
"name": "hexose",
"pos": [
66,
72
]
} |
the nucleoproteins resulting from digestion of the nuclei of the true slime mold pysarum polycephalum with micrococcal nuclease have been resolved according to the size classes in linear sucrose gradients containg 0.5 m nacl , and analysed for dna , rna and protein content . | NA | {
"id": "C0028612",
"name": "nucleoproteins",
"pos": [
4,
18
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
258,
265
]
} |
the basic nucleoprotein subunit has been found to contain a dna fragment of about 150 -- 170 base pairs complexed with an approximately equal amount , on a weight basis , of basic proteins and a relatively small amount of non-histone proteins ( about 35 % of the amount of dna ) . | NA | {
"id": "C0028612",
"name": "nucleoprotein",
"pos": [
10,
23
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
234,
242
]
} |
the basic nucleoprotein subunit has been found to contain a dna fragment of about 150 -- 170 base pairs complexed with an approximately equal amount , on a weight basis , of basic proteins and a relatively small amount of non-histone proteins ( about 35 % of the amount of dna ) . | NA | {
"id": "C0000702",
"name": "a dna",
"pos": [
58,
63
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
273,
276
]
} |
both the basic subunit and higher nucleoprotein oligomers of physarum chromatin contain some amount of tightly bound rna . | NA | {
"id": "C0028612",
"name": "nucleoprotein",
"pos": [
34,
47
]
} | {
"id": "C0008546",
"name": "chromatin",
"pos": [
70,
79
]
} |
non-specific incorporation ( de novo polynucleotide synthesis , random attachment to existing strands , and tritium exchange of nucleotides ) accounted for , at most , a small fraction of the total observed misincorporation . | NA | {
"id": "C0032550",
"name": "polynucleotide",
"pos": [
37,
51
]
} | {
"id": "C0028630",
"name": "nucleotides",
"pos": [
128,
139
]
} |
differential labelling of the ribosomal proteins was observed in both strains : proteins from the rel+ strain appear more labelled than those from the rel- strain , the rate of labelling of individual proteins being about the same in both strains . | NA | {
"id": "C0035552",
"name": "ribosomal proteins",
"pos": [
30,
48
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
201,
209
]
} |
experiments testing the influence of base-pairing of the iodopyrimidines in synthetic polynucleotides showed that pairing of the substituted nucleotide protected the iodine bond . | NA | {
"id": "C0032550",
"name": "polynucleotides",
"pos": [
86,
101
]
} | {
"id": "C0028630",
"name": "nucleotide",
"pos": [
141,
151
]
} |
the release of iodine from double stranded rna and dna-rna duplexes was retarded in comparison with the release from ribosomal and messenger rna fractions . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
43,
46
]
} | {
"id": "C0035696",
"name": "messenger rna",
"pos": [
131,
144
]
} |
while the destabilization caused by this protein fraction was greater than that caused by an equal amount of albumin , as tested the effect was non-specific . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
41,
48
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
109,
116
]
} |
the effect of this complex formation on the hydrolysis of the ester is to lower the rate by a factor of 4 in solutions containing 1 m guanidine hydrochloride when compared with solutions of the same total ionic strength containing no guanidinium ion . | NA | {
"id": "C0120447",
"name": "guanidine hydrochloride",
"pos": [
134,
157
]
} | {
"id": "C0120446",
"name": "guanidinium",
"pos": [
234,
245
]
} |
the pyruvate kinase ( atp : pyruvate 2-o-phosphotransferase , ec 2.7.1.40 ) from streptococcus lactis c10 had an obligatory requirement for both a monovalent cation and divalent cation . | NA | {
"id": "C0007447",
"name": "cation",
"pos": [
158,
164
]
} | {
"id": "C0007448",
"name": "divalent cation",
"pos": [
169,
184
]
} |
preincubation of pyrophosphatase with naf and various metal cations and substrates , in conditions where the enzyme does not act as a catalyst , does not affect its activity compared to controls lacking fluoride . | NA | {
"id": "C0037508",
"name": "naf",
"pos": [
38,
41
]
} | {
"id": "C0016327",
"name": "fluoride",
"pos": [
203,
211
]
} |
the inhibition of guinea-pig heart ( na+ + k+ ) -atpase ( atp phosphohydrolase ec 3.6.1.3 ) by calcium has been studied at ph 7.4 , 6.8 and 6.4 . | NA | {
"id": "C0001479",
"name": "na",
"pos": [
37,
39
]
} | {
"id": "C0001473",
"name": "atp phosphohydrolase",
"pos": [
58,
78
]
} |
the ca2+ -activated atpase of myosin b which is related to the contractile behaviour of muscle and the ca2+ -atpase of the sarcoplasmic reticulum which is related to the ability of this structure to accumulate calcium were activated in a range of calcium concentration producing an inhibition of ( na2+ + k+ ) -atpase . | NA | {
"id": "C0001476",
"name": "ca2",
"pos": [
4,
7
]
} | {
"id": "C0916181",
"name": "ca2",
"pos": [
103,
106
]
} |
the ca2+ -activated atpase of myosin b which is related to the contractile behaviour of muscle and the ca2+ -atpase of the sarcoplasmic reticulum which is related to the ability of this structure to accumulate calcium were activated in a range of calcium concentration producing an inhibition of ( na2+ + k+ ) -atpase . | NA | {
"id": "C0001476",
"name": "ca2",
"pos": [
4,
7
]
} | {
"id": "C0001473",
"name": "atpase",
"pos": [
311,
317
]
} |
a six-membered ring formed by hydrogen bonding between 0 ( 3 ' ) -h and 0-1 ' appears more favorable than an eight-membered ring involving an anionic oxygen instead of an ester oxygen related to the phosphate group . | NA | {
"id": "C0003075",
"name": "anionic",
"pos": [
142,
149
]
} | {
"id": "C0031603",
"name": "phosphate",
"pos": [
199,
208
]
} |
controlled proteolysis of the enzyme converts the native form of the enzyme to a protease-activated form which has a specific activity about 20-fold greater than the native oxidase . | NA | {
"id": "C0030940",
"name": "proteolysis",
"pos": [
11,
22
]
} | {
"id": "C0030946",
"name": "protease",
"pos": [
81,
89
]
} |
amino acid analysis reveals high quantities of glutamic acid , glycine , serine , arginine and relatively high levels of histidine , with these five amino acids composing 74 % of the total residues . | NA | {
"id": "C0017890",
"name": "glycine",
"pos": [
63,
70
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
149,
160
]
} |
incubation of cultured human fibroblasts with blood coagulation factor xiiia ( plasma transglutaminase , fibrinoligase ) and the fluorescent primary amine , n- ( 5-aminopentyl ) -5-dimethylaminonaphthalene-1-sulfonamide , resulted in fluorescent labeling of three cellular polypeptides . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
29,
40
]
} | {
"id": "C0007634",
"name": "cellular",
"pos": [
264,
272
]
} |
interaction between serum and a mixture of antibodies to a-i , a-ii and apolipoprotein d resulted in the formation of separate lipoprotein a and lipoprotein d rockets indicating that apolipoprotein d is not a constituent polypeptide of apolipoprotein a . | NA | {
"id": "C0065058",
"name": "lipoprotein a",
"pos": [
127,
140
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
239,
250
]
} |
these findings should allow more rapid processing of plasma containing high myocardial depressant factor activity to separate the factor and to completely identify this small peptide of great physiologic interest . | NA | {
"id": "C0027047",
"name": "myocardial depressant factor",
"pos": [
76,
104
]
} | {
"id": "C0030956",
"name": "peptide",
"pos": [
175,
182
]
} |
light angiotensin enzyme was activated by nacl and inhibited by edta , angiotensin ii , and bradykinin potentiating factor nonapeptide . | NA | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
6,
17
]
} | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
71,
85
]
} |
previous studies had shown that the basic homopolypeptides ( poly-l-lysine , poly-l-arginine ) assume alpha-helical conformation upon interaction with numerous glycosaminoglycans ( including heparin ) . | NA | {
"id": "C0017973",
"name": "glycosaminoglycans",
"pos": [
160,
178
]
} | {
"id": "C0019134",
"name": "heparin",
"pos": [
191,
198
]
} |
in an attempt to search for growth hormone fragments in the pituitary , a radioimmunoassay was developed for a 55 residue s-amino-ethylated cnbr fragment ( fragment b ) of porcine growth hormone corresponding to residues 126-180 of human growth hormone . | NA | {
"id": "C0037663",
"name": "growth hormone",
"pos": [
28,
42
]
} | {
"id": "C0169964",
"name": "human growth hormone",
"pos": [
232,
252
]
} |
analysis because of death revealed very significant increases in the incidence of congenital defects , asphyxia and 'no major lesion ' when the preceding delivery had been either an abortion or an sbnd . | NA | {
"id": "C0011065",
"name": "death",
"pos": [
20,
25
]
} | {
"id": "C0004044",
"name": "asphyxia",
"pos": [
103,
111
]
} |
the ph-activity profiles of beta-d-glucosidase , glucoamylase , peroxidase , uricase , and d-glucose oxidase were virtually unchanged on immobilization while those of catalase and dextranase were significantly altered . beta-d-glucosidase , glucoamylase , and glucose oxidase were found to be more susceptible to denaturation on lyophilization when immobilized than in the native state ; | NA | {
"id": "C0017764",
"name": "glucosidase",
"pos": [
35,
46
]
} | {
"id": "C0015278",
"name": "glucoamylase",
"pos": [
241,
253
]
} |
the above data are consistent with the view that s. mansoni adults possess an anticoagulant that is capable of specifically inhibiting the conversion of factor xi to factor xia by factor xiia . | NA | {
"id": "C0015522",
"name": "factor xi",
"pos": [
153,
162
]
} | {
"id": "C0015524",
"name": "factor xia",
"pos": [
166,
176
]
} |
absence of gamma-glutamyl transpeptidase and the role of gssg transport in the turnover of gsh in erythrocytes . | NA | {
"id": "C0061516",
"name": "gssg",
"pos": [
57,
61
]
} | {
"id": "C0017817",
"name": "gsh",
"pos": [
91,
94
]
} |
1 the role of monoamine oxidase ( mao ) in the maintenance of deoxycorticosterone-sodium chloride ( doca-salt ) hypertension was investigated by assaying the mao activity both in central as well as peripheral blood vessels and in brain tissue . | NA | {
"id": "C0011710",
"name": "deoxycorticosterone",
"pos": [
62,
81
]
} | {
"id": "C0813203",
"name": "doca-salt",
"pos": [
100,
109
]
} |
responses of the hepatic arterial vascular bed of the dog to intra-arterial injections of noradrenaline , adrenaline and phenylephrine : the role of beta-adrenoceptors [ proceedings ] . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
90,
103
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
106,
116
]
} |
electron microscopic autoradiographic localization of [ 3h ] -dopamine in the dendrites of the dopaminergic neurones of the rat substantia nigra in vivo [ proceedings ] . | NA | {
"id": "C0013030",
"name": "dopamine",
"pos": [
62,
70
]
} | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
95,
107
]
} |
three tetracyclines were compared ina randomised trial which showed that low-dose oxytetracycline ( 250 mg twice a day ) was as effective as preparations formulated specifically for twice daily administration ( triple tetracycline and sustained-release tetracycline hydrochloride ) . | NA | {
"id": "C0039651",
"name": "tetracyclines",
"pos": [
6,
19
]
} | {
"id": "C0030092",
"name": "oxytetracycline",
"pos": [
82,
97
]
} |
three tetracyclines were compared ina randomised trial which showed that low-dose oxytetracycline ( 250 mg twice a day ) was as effective as preparations formulated specifically for twice daily administration ( triple tetracycline and sustained-release tetracycline hydrochloride ) . | NA | {
"id": "C0039644",
"name": "tetracycline",
"pos": [
6,
18
]
} | {
"id": "C0546879",
"name": "tetracycline hydrochloride",
"pos": [
253,
279
]
} |
a new anti-protozoal compound , ornidazole , a derivative of nitroimidazole , was given in a single 2 g dose to 20 women with trichomonas vaginalis infection . | NA | {
"id": "C0029274",
"name": "ornidazole",
"pos": [
32,
42
]
} | {
"id": "C0028179",
"name": "nitroimidazole",
"pos": [
61,
75
]
} |
cobalt epilepsy was accompanied by changes in a larger number of amino acids than penicillin epilepsy : in the former the brain content of taurine , gaba , aspartate , glutamate , serine , threonine , glycine and alanine was altered . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
65,
76
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
201,
208
]
} |
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