sentence
stringlengths 20
553
| entities
listlengths 0
5
|
|---|---|
The spleen was also removed . | [] |
The end of the pancreas was suture ligated . | [] |
Her post-operative recovery was uneventful . | [] |
Histological examination of the specimen showed a well circumscribed ovoid tumour 60 mm x 50 mm across . | [
{
"offsets": [
75,
81
],
"text": "tumour",
"type": "CLINENTITY"
}
] |
Sections revealed islands and trabeculae of regular cells with variable amounts of eosinophilic cytoplasm , mostly regular nuclei with indistinct nucleoli . | [] |
Areas of necrosis were present with hemorrhage . | [
{
"offsets": [
9,
17
],
"text": "necrosis",
"type": "CLINENTITY"
},
{
"offsets": [
36,
46
],
"text": "hemorrhage",
"type": "CLINENTITY"
}
] |
A fibrous pseudo-capsule was noted around the tumour and the resection of the tumour appeared complete . | [
{
"offsets": [
46,
52
],
"text": "tumour",
"type": "CLINENTITY"
}
] |
No capsular of vascular invasion was seen . | [] |
Immuno-peroxidase staining was positive for chromogranin A . | [] |
Synaptophysin was strongly positive , CD 10 was negative , Ki- 67 was less than 2 % positive and the mitotic count was between 2-20 per 10 hpf . | [] |
The staining reactions were confirmatory of a neuroendocrine carcinoma of the pancreas . | [
{
"offsets": [
46,
86
],
"text": "neuroendocrine carcinoma of the pancreas",
"type": "CLINENTITY"
}
] |
The final staging of the completely excised tumour was T 3 N 0 M 0 . | [] |
Following discharge , she was followed up regularly and remains symptom free . | [] |
A CT Scan performed 2 years after surgery showed no evidence of tumour recurrence . | [] |
A 49 - year-old white Caucasian woman presented with vaginal bleeding . | [
{
"offsets": [
53,
69
],
"text": "vaginal bleeding",
"type": "CLINENTITY"
}
] |
A pelvic examination revealed a cystic lesion arising from her cervix . | [
{
"offsets": [
32,
45
],
"text": "cystic lesion",
"type": "CLINENTITY"
}
] |
Examination of a biopsy specimen revealed a poorly differentiated neoplasm , with sheets of small hyperchromatic cells , staining weakly for neuroendocrine markers . | [] |
She was diagnosed with small cell carcinoma and started on concurrent chemotherapy and radiation . | [
{
"offsets": [
23,
43
],
"text": "small cell carcinoma",
"type": "CLINENTITY"
}
] |
However , additional positive immunostaining for CD 99 was strongly suggestive of Ewing ' s sarcoma . | [
{
"offsets": [
82,
99
],
"text": "Ewing ' s sarcoma",
"type": "CLINENTITY"
}
] |
Fluorescence in situ hybridization revealed ESWR 1 gene rearrangement , confirming Ewing ' s sarcoma . | [
{
"offsets": [
83,
100
],
"text": "Ewing ' s sarcoma",
"type": "CLINENTITY"
}
] |
Our patient underwent surgery , which confirmed stage IIB Ewing ' s sarcoma . | [
{
"offsets": [
58,
75
],
"text": "Ewing ' s sarcoma",
"type": "CLINENTITY"
}
] |
She received adjuvant chemotherapy but died from progressive metastatic disease after four cycles . | [
{
"offsets": [
61,
79
],
"text": "metastatic disease",
"type": "CLINENTITY"
}
] |
A 62 - year-old woman presented with complaints of epigastric pain and vomiting . | [
{
"offsets": [
51,
66
],
"text": "epigastric pain",
"type": "CLINENTITY"
}
] |
Computed tomography showed a 27 - mm , hyper-enhancing tumor in the prepyloric antrum . | [
{
"offsets": [
55,
60
],
"text": "tumor",
"type": "CLINENTITY"
}
] |
Upper endoscopy also showed a submucosal tumor causing subtotal obstruction of the gastric outlet . | [
{
"offsets": [
30,
46
],
"text": "submucosal tumor",
"type": "CLINENTITY"
}
] |
Because a gastrointestinal stromal tumor was suspected , distal gastrectomy was performed . | [
{
"offsets": [
10,
40
],
"text": "gastrointestinal stromal tumor",
"type": "CLINENTITY"
}
] |
Histopathological examination revealed spindle cell proliferation in the submucosal layer . | [
{
"offsets": [
39,
65
],
"text": "spindle cell proliferation",
"type": "CLINENTITY"
}
] |
The spindle cells had invaded the muscularis propria layer and extended to the subserosal layer . | [] |
The tumor was finally diagnosed as an IFP based on immunohistochemical findings . | [
{
"offsets": [
4,
9
],
"text": "tumor",
"type": "CLINENTITY"
}
] |
No mutations were identified in the platelet-derived growth factor receptor alpha ( PDGFRA ) gene via molecular genetic analysis . | [] |
A 36 - year-old female showed mild swelling in the right upper eyelid . | [] |
She lost her RGP contact lens seven months prior to her first visit , from trauma by her child ' s kick to the right eye . | [] |
At the first examination , we felt a firm lump inferior to the right brow . | [
{
"offsets": [
42,
46
],
"text": "lump",
"type": "CLINENTITY"
}
] |
Eversion of the upper eyelid also revealed a firm subconjunctival mass superior to the upper tarsus . | [
{
"offsets": [
50,
70
],
"text": "subconjunctival mass",
"type": "CLINENTITY"
}
] |
After incising the conjunctiva , the RGP contact lens was found without a fibrous capsule and granulation tissue in the subconjunctival space . | [] |
Three years after removal of the lens , the patient did not show any complications , including ptosis . | [
{
"offsets": [
95,
101
],
"text": "ptosis",
"type": "CLINENTITY"
}
] |
A 17 year-old woman with a history of moderate persistent allergic asthma has benefited from a first desensitization protocol at age 3 . | [
{
"offsets": [
38,
73
],
"text": "moderate persistent allergic asthma",
"type": "CLINENTITY"
}
] |
The protocol has been interrupted 4 years later because of a mild skin reaction . | [] |
Her doctor decided to stop the specific immunotherapy . | [] |
But another doctor restarted a new protocol of desensitization at age 16 against pollens because of a lack of control of his condition . | [] |
She was never hospitalized , she was receiving no medication and she was doing well one year after she received a new regimen of pneumallergens ( Alustal ® Stallergenes SA , France ) . | [] |
Indeed , 12 hours after initiation of treatment , she complained of abdominal pain , vomiting and diarrhea without fever . | [
{
"offsets": [
68,
82
],
"text": "abdominal pain",
"type": "CLINENTITY"
},
{
"offsets": [
85,
93
],
"text": "vomiting",
"type": "CLINENTITY"
},
{
"offsets": [
98,
106
],
"text": "diarrhea",
"type": "CLINENTITY"
}
] |
Several hours after , she consulted to the emergency department where a surgical emergency was ruled out . | [] |
She was then admitted to the internal medicine ward . | [] |
Two days later , she developed an acute respiratory failure and was referred to the intensive care unit where laboratory tests revealed multiorgan failure : liver enzymes , 5000 U / L ( normal level , 0 -37 U / L ) ; creatine phosphokinase , 59000 U / L ( normal level , 10 -200 U / L ) ; cardiac troponin T , 21 ng / ml ( normal level , under 0 , 01 ng / ml ) ; leucopenia , 2600 / mm 3 ( normal level , 4000-9000 / mm 3 ) ; thrombocytopenia , 13000 / mm 3 ( normal level , 150000-400000 / mm 3 ) ; prothrombin time , 38 % ( normal level , 70-100 % ) . | [
{
"offsets": [
34,
59
],
"text": "acute respiratory failure",
"type": "CLINENTITY"
},
{
"offsets": [
136,
154
],
"text": "multiorgan failure",
"type": "CLINENTITY"
}
] |
Chest X-ray demonstrated bilateral interstitial markings with a normal cardiac silhouette . | [
{
"offsets": [
35,
56
],
"text": "interstitial markings",
"type": "CLINENTITY"
}
] |
Viral serology was normal for hepatitis A , B , C , D , and E , Epstein-Barr virus and Cytomegalovirus . | [] |
A skin morbilliform rash and facial edema appeared later . | [
{
"offsets": [
2,
24
],
"text": "skin morbilliform rash",
"type": "CLINENTITY"
},
{
"offsets": [
29,
41
],
"text": "facial edema",
"type": "CLINENTITY"
}
] |
The patient received a fluid resuscitation , platelet and erythrocyte transfusion , steroids and antibiotics . | [] |
A hypoxic coma occurred on day 4 leading to intubation and mechanical ventilation . | [
{
"offsets": [
2,
14
],
"text": "hypoxic coma",
"type": "CLINENTITY"
}
] |
Rapidly , she experienced intractable shock and acute renal impairment despite inotropic agents leading to death on day 5 . | [
{
"offsets": [
38,
43
],
"text": "shock",
"type": "CLINENTITY"
},
{
"offsets": [
48,
70
],
"text": "acute renal impairment",
"type": "CLINENTITY"
}
] |
Here , we present a case of unicentric Castleman ' s disease in a 37 - year-old woman without associated neoplastic , autoimmune or infectious diseases . | [
{
"offsets": [
39,
60
],
"text": "Castleman ' s disease",
"type": "CLINENTITY"
},
{
"offsets": [
105,
151
],
"text": "neoplastic , autoimmune or infectious diseases",
"type": "CLINENTITY"
}
] |
The lesion was located in the femoral region of the right lower extremity and surgically resected after radiographic workup and excisional biopsy examinations . | [
{
"offsets": [
4,
10
],
"text": "lesion",
"type": "CLINENTITY"
}
] |
The tumor comprised lymphoid tissue with numerous germinal centers with central fibrosis , onion-skinning and rich interfollicular vascularization . | [
{
"offsets": [
4,
9
],
"text": "tumor",
"type": "CLINENTITY"
},
{
"offsets": [
20,
35
],
"text": "lymphoid tissue",
"type": "CLINENTITY"
},
{
"offsets": [
80,
88
],
"text": "fibrosis",
"type": "CLINENTITY"
},
{
"offsets": [
91,
105
],
"text": "onion-skinning",
"type": "CLINENTITY"
}
] |
CD 23 - positive follicular dendritic cells were detected in the germinal centers and numerous CD 138 - positive plasma cells in interfollicular areas . | [
{
"offsets": [
0,
43
],
"text": "CD 23 - positive follicular dendritic cells",
"type": "CLINENTITY"
}
] |
The diagnosis of mixed cellularity type Castleman ' s disease was established and the patient recovered well . | [
{
"offsets": [
40,
61
],
"text": "Castleman ' s disease",
"type": "CLINENTITY"
}
] |
An eleven year old girl presented to the paediatric eye clinic of the University College Hospital , Ibadan , Nigeria with a history of squint and poor vision . | [
{
"offsets": [
146,
157
],
"text": "poor vision",
"type": "CLINENTITY"
}
] |
Her mother had noticed a misalignment of the eyes three years previously and the patient had been complaining about poor distance vision for about a year . | [
{
"offsets": [
116,
136
],
"text": "poor distance vision",
"type": "CLINENTITY"
}
] |
There was no history of antecedent trauma to the head or face . | [] |
There was no history of double vision ( diplopia ) or pains on ocular movements . | [
{
"offsets": [
24,
37
],
"text": "double vision",
"type": "CLINENTITY"
},
{
"offsets": [
40,
48
],
"text": "diplopia",
"type": "CLINENTITY"
}
] |
There was no associated headache , fever , vomiting , joint pains or skin rashes / lesions . | [
{
"offsets": [
24,
32
],
"text": "headache",
"type": "CLINENTITY"
},
{
"offsets": [
35,
40
],
"text": "fever",
"type": "CLINENTITY"
},
{
"offsets": [
43,
51
],
"text": "vomiting",
"type": "CLINENTITY"
},
{
"offsets": [
69,
90
],
"text": "skin rashes / lesions",
"type": "CLINENTITY"
}
] |
The review of systems was essentially normal and she had enjoyed good health since early childhood . | [] |
Her pregnancy and delivery were uneventful ; and her development was normal . | [] |
All other family members were well and there was no family history of squint . | [
{
"offsets": [
70,
76
],
"text": "squint",
"type": "CLINENTITY"
}
] |
Unaided visual acuity was 6 / 24 in the right eye and counting fingers ( CF ) in the left eye . | [] |
During refraction , her visual acuity improved to 6 / 9 and 6 / 60 in the right and left eyes respectively . | [] |
The refractive error was a hypermetropia of + 4 . 50 diopters in each eye . | [
{
"offsets": [
27,
40
],
"text": "hypermetropia",
"type": "CLINENTITY"
}
] |
Examination revealed normal anterior and posterior segments bilaterally . | [] |
There was about 10 prism diopters of left hypotropia with no horizontal deviation in the primary position and she did not have an abnormal head posture . | [
{
"offsets": [
42,
52
],
"text": "hypotropia",
"type": "CLINENTITY"
}
] |
Her palpebral fissures were normal and equal on both sides in the primary position of gaze . | [] |
Examination of the ocular motility elicited marked limitation of elevation of the left eye when looking to the right , while elevation of the same eye was almost full on left gaze . | [] |
The movements of the right eye were normal and there were no significant changes in the palpebral fissures of both eyes during eye movements . | [] |
Forced duction test ( performed under sedation ) was positive and revealed marked restriction of passive elevation of the left eye in adduction . | [] |
Her systemic examination was completely normal . | [] |
A diagnosis of congenital left Brown syndrome with severe amblyopia was made . | [
{
"offsets": [
15,
45
],
"text": "congenital left Brown syndrome",
"type": "CLINENTITY"
},
{
"offsets": [
58,
67
],
"text": "amblyopia",
"type": "CLINENTITY"
}
] |
Spectacles were prescribed and she was commenced on a trial of amblyopia therapy which consisted of patching of the right eye for a period of 3-4 hours every day ( after school ) . | [] |
Her mother was counselled and educated about the condition as well as the treatment plan . | [] |
Specifically , she was informed that surgery was necessary to correct the squint , irrespective of the outcome of the amblyopia therapy . | [
{
"offsets": [
74,
80
],
"text": "squint",
"type": "CLINENTITY"
}
] |
A three month follow up visit was scheduled , however , the patient defaulted after the initial visit . | [] |
A 64 - year-old woman was admitted to our institution with palpable lump in her left breast . | [
{
"offsets": [
59,
72
],
"text": "palpable lump",
"type": "CLINENTITY"
}
] |
Patient had not any previous medical and family story of cancer and denied any use of alcohol and cigarettes . | [
{
"offsets": [
57,
63
],
"text": "cancer",
"type": "CLINENTITY"
}
] |
She took oral contraception for 5 years . | [] |
Her menarche was at age 12 . | [] |
Physical examination revealed a 3 cm tumor located on the left breast adhere to deep plans . | [
{
"offsets": [
37,
42
],
"text": "tumor",
"type": "CLINENTITY"
}
] |
There was no retraction of the nipple , skin ulceration or inflammatory changes . | [
{
"offsets": [
13,
37
],
"text": "retraction of the nipple",
"type": "CLINENTITY"
},
{
"offsets": [
40,
55
],
"text": "skin ulceration",
"type": "CLINENTITY"
}
] |
The right breast exam was negative and there was no clinical evidence of axillary lymph node involvement . | [] |
Mammography revealed a 2 . 6 cm round hyperdense mass with irregular and speculated margins in the subareolar area with associated microcalcifications within the mass . | [
{
"offsets": [
131,
150
],
"text": "microcalcifications",
"type": "CLINENTITY"
}
] |
The mass was categorized as Breast Imaging Reporting and Data System category 5 . | [] |
Fine needle aspiration and a core biopsy of the lesion were performed and the diagnostic was tubular carcinoma of the breast . | [
{
"offsets": [
93,
124
],
"text": "tubular carcinoma of the breast",
"type": "CLINENTITY"
}
] |
The patient underwent left lumpectomy with axillary node dissection . | [] |
The macroscopic ( gross ) examination of specimens revealed the presence of a nodule measuring 1 . 5 cm in its largest diameter . | [
{
"offsets": [
78,
84
],
"text": "nodule",
"type": "CLINENTITY"
}
] |
The histology showed that tumor cells were arranged in a rare trabecular pattern with a prominent lymphoid stroma . | [
{
"offsets": [
62,
80
],
"text": "trabecular pattern",
"type": "CLINENTITY"
}
] |
Carcinomatous cells were polygonal with granular amphophilic cytoplasm and a nucleus with fine chromatin . | [] |
Nucleoli were generally inconspicuous . | [] |
Up to 8 mitoses per 10 HPF were counted . | [] |
No lympho-vascular component or intraductal component was noted . | [] |
The tumor was grade II of Scarf Bloom Richardson . | [
{
"offsets": [
4,
9
],
"text": "tumor",
"type": "CLINENTITY"
}
] |
Surgical margin was clear . | [] |
The resected axillary lymph nodes contained metastases , including one / 19 N level I lymph nodes . | [
{
"offsets": [
44,
54
],
"text": "metastases",
"type": "CLINENTITY"
}
] |
The immunohistochemistry study showed an expression of the following antibodies Ck ( AE 1 / AE 3 ) on the carcinomatous component , CD 3 and CD 20 with homogenous distribution in the stroma . | [] |
Subsets and Splits