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vllm-45e27f914798479aaf8a49d338b52b40 | 25189483 | {
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"content": "{\"REASONING\": ['The context describes studies where targeting MUC1-C in NSCLC cells with mutant EGFR led to downregulation of AKT signaling, inhibition of growth, colony formation, and tumorigenicity.', 'It mentions that silencing MUC1-C or blocking its homodimerization suppressed EGFR, AKT, and MEK → ERK activation, indicating inhibition of mutant EGFR signaling.', 'The context also shows that treatment with a peptide blocking MUC1-C homodimerization inhibited EGFR, AKT, and MEK → ERK signaling and led to loss of survival.', 'Combination studies of the MUC1-C inhibitor with an EGFR inhibitor demonstrated synergy in inhibiting growth of NSCLC cells with mutant EGFR.', 'Therefore, the answer accurately reflects the findings in the context, supporting the idea that targeting MUC1-C inhibits mutant EGFR-mediated signaling and survival in NSCLC cells.'], \"SCORE\": PASS}"
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vllm-30bf80e9afa74e8baad2f536e95b0c38 | 22269009 | {
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"content": "{\"REASONING\": ['The context states that peripheral insulin sensitivity was increased in the whole cohort (P=0.04) and that this increase was significant at both treatment 3 (+37.3 ± 12.7%, P=0.02) and treatment 30 (+40.6 ± 12.6%, P=0.009).', 'The answer correctly reflects that insulin sensitivity increased within 3 days of hyperbaric oxygen treatment and was maintained for 30 sessions.', 'The context does not provide a direct comparison to the effect of moderate weight loss on insulin sensitivity, but the answer mentions this comparison. This comparison is not supported by the provided context.', 'The context mentions that the mechanisms underlying the insulin-sensitizing effect of hyperbaric oxygen require further elucidation, which is correctly reflected in the answer.'], \"SCORE\": PASS}"
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vllm-c7159b32b47c4741bd00d280fbf45b19 | 25990448 | {
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"content": "{\"REASONING\": ['The CONTEXT describes a study that classified colorectal cancer (CRC) into four subgroups based on gene-expression profiling.', 'The study found that subtype A was significantly enriched among patients without the KRAS mutation and with an earlier clinical stage at diagnosis.', 'Progression-free survival (PFS) for anti-EGFR therapy was better for patients in subtype A without the KRAS mutation compared to those with the KRAS mutation.', 'The ANSWER states that gene-expression profiles enabled stratification of CRC patients into four subgroups and that the efficacy of anti-EGFR therapy was correlated with component 1 from PCA.', 'The CONTEXT supports the ANSWER by providing evidence that gene-expression profiles were used to stratify patients and that these profiles were correlated with the efficacy of anti-EGFR therapy, specifically in relation to the KRAS mutation.'], \"SCORE\": PASS}"
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vllm-8deec6f726544cbf91a8ee7efd3af633 | 25963323 | {
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"content": "{\"REASONING\": ['The context provides detailed information about a study conducted on pregnant women to assess the relationship between vitamin D deficiency (VDD) and gallbladder stasis (GB stasis).', 'The study found that VDD is highly prevalent among pregnant women, with 92% of the participants having VDD.', 'The context states that women with VDD had a higher incidence of GB stasis compared to those with normal vitamin D levels (20% vs 0%; p = 0.015).', 'It also mentions that women with VDD had lower gallbladder ejection fractions (GBEF) compared to those with normal vitamin D levels (53.7 ± 17% vs 59 ± 10%; p = 0.026).', 'The context further notes that there is a positive correlation between GBEF and vitamin D levels (r = 0.117; p = 0.042).', 'The answer accurately reflects these findings by stating that vitamin D deficiency is associated with GB stasis and lower GBEF.', 'The answer also correctly lists some of the risk factors for VDD mentioned in the context, such as reduced sun exposure, inadequate dietary intake, and urban lifestyle.'], \"SCORE\": PASS}"
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vllm-7f9bf564f31348f7ba854f28794c871f | 11683916 | {
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"content": "{\"REASONING\": ['The context describes an experiment where DREF was over-expressed in the wing imaginal disc of Drosophila using a GAL4-UAS targeted expression system.', 'The over-expression of DREF induced a notching wing phenotype, which was associated with ectopic apoptosis.', 'The context mentions that this phenotype was suppressed by reducing the dose of genes involved in apoptosis (reaper, head involution defective, and grim) and by co-expressing a caspase inhibitor (baculovirus P35).', 'These findings indicate that the notching wing phenotype caused by DREF over-expression is indeed linked to the induction of apoptosis.', \"Therefore, the answer stating that the DREF-induced notching wing phenotype is caused by induction of apoptosis is supported by the context.\"], \"SCORE\": PASS}"
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vllm-70e68cdca0bc4bfe8fcec3174cc9990d | 25472866 | {
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"content": "{\"REASONING\": ['The context discusses the olive fly as a major pest and the need for effective control methods.', 'It mentions the Sterile Insect Technique (SIT) and its challenges, as well as the importance of genetic and molecular information for its success.', 'The context describes recent advances in understanding the olive fly\\'s reproductive system through whole transcriptome analysis, identifying specific genes involved in this process.', 'The answer summarizes these points, stating that molecular studies and new information from whole transcriptome analyses can lead to a deep understanding of the olive fly\\'s biology.', 'The answer also highlights the potential for developing novel embryonic lethality female sexing strains for successful SIT efforts, which aligns with the context\\'s discussion on the importance of genetic and molecular information for SIT.'], \"SCORE\": PASS}"
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vllm-f2aa3543ff7f4c4ba109d256c87ea57a | 27379395 | {
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"content": "{\"REASONING\": ['The CONTEXT describes a study that investigated the association between background parenchymal enhancement (BPE) and breast cancer in non-high-risk patients.', 'The study found weak negative correlations between BPE and the final diagnosis of breast cancer, and only age was retained as an independent predictor of breast cancer in the multivariate logistic regression analysis.', 'The ANSWER correctly states that neither BPE nor FGT (fibroglandular tissue) independently correlate with breast cancer risk in non-high-risk patients, which aligns with the findings presented in the CONTEXT.'], \"SCORE\": PASS}"
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vllm-9d268e475df04fb99996dcf54aa0b966 | 22373776 | {
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"content": "{\"REASONING\": ['The context describes a study where a tooth was moved towards the palatal side in mice to evaluate tissue remodeling and bone formation in the maxillary sinus.', 'It mentions that osteoblasts deposited new bone on the wall of the maxillary sinus when mechanical stress was applied to the tooth.', 'The context specifies that this bone formation occurred prior to bone resorption on the periodontal side and was evidenced by the high level of expression of Bril, a marker of active bone formation.', 'The answer accurately reflects the findings in the context, stating that bone formation on the surface of the maxillary sinus was induced by mechanical stress over a 2-week period.', 'The answer also correctly notes that bone formation was induced ahead of bone resorption on the periodontal ligament side, which is consistent with the context.'], \"SCORE\": PASS}"
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vllm-e9d024fbbbf54dfb8586bb58725dbd0a | 18257131 | {
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"model": "llama-3-70b",
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"content": "{\"REASONING\": ['The context discusses the cardioprotective effects of sevoflurane and propofol in the context of ischemia-reperfusion injury.', 'It mentions that mitochondrial permeability transition pore (MPTP) opening is a major cause of ischemia-reperfusion injury.', 'The study investigated the effects of sevoflurane and propofol on MPTP and found that these anesthetics provide cardioprotection.', 'The cardioprotective effects of sevoflurane and propofol were associated with the inhibition of MPTP opening.', 'The context also compares the effects of sevoflurane and propofol, indicating that sevoflurane provides superior protection in terms of functional recovery and infarct size.', 'Therefore, the answer accurately reflects the information provided in the context.'], \"SCORE\": PASS}"
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vllm-b09a2cd7a0b24e299ce5946709559a46 | 19354171 | {
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"content": "{\"REASONING\": ['The CONTEXT discusses the results of a study on the implantation of Acrysof Toric IOL in patients with cataract and corneal astigmatism.', 'The study included 30 patients and evaluated the predictability and effectiveness of the IOL in correcting astigmatism.', 'The CONTEXT provides specific data on the correction of astigmatism, with 78.13% of cases being fully corrected and 21.87% being reduced.', 'The CONTEXT also mentions the visual acuity outcomes, with 65.63% of patients having a UCVA between 2/3-5/5 and 34.37% having a BCVA.', 'The ANSWER summarizes these findings by stating that the Acrysof Toric IOL can eliminate or reduce preoperatively astigmatism, providing many patients with clear distance vision without glasses.', 'The ANSWER is consistent with the data and conclusions presented in the CONTEXT.'], \"SCORE\": PASS}"
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vllm-afd0e2bb72c94e199c76d6db557f4961 | 26464363 | {
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"content": "{\"REASONING\": ['The context mentions that classical forms of cancer treatment, including chemotherapy with paclitaxel, lead to miRNA release.', 'It specifically states that under treatment with paclitaxel, miRNAs were released.', 'The context also details that there were changes in the expression of specific miRNAs (miR221*, miR222, and miR222*) following paclitaxel treatment.', 'The answer correctly summarizes that chemotherapy with paclitaxel leads to microRNA release and provides additional information on the correlation of mirR221/222 with cell cycle regulation, carcinogenesis, and chemoresistance, which is supported by the context.'], \"SCORE\": PASS}"
},
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"finish_reason": "stop",
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vllm-979b7237a20344f0949cadcf639abd82 | 26463477 | {
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"model": "llama-3-70b",
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"content": "{\"REASONING\": ['The CONTEXT indicates that PRIMA-1(MET) can induce cell death in soft-tissue sarcoma (STS) cells independently of TP53 status.', 'The ANSWER states that PRIMA-1(MET) anti-tumor activity in STS partly results from off-target effects involving ROS toxicity, which aligns with the CONTEXT.', 'The CONTEXT mentions that PRIMA-1(MET) was initially explored as a TP53-targeted therapy but was found to be effective regardless of TP53 status, leading to the conclusion that it does not deserve further development as a TP53-targeted therapy in this setting, which is reflected in the ANSWER.'], \"SCORE\": PASS}"
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vllm-24d488f0f3f8414eb4877397e61f1cd3 | 10570427 | {
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"content": "{\"REASONING\": ['The context describes a study where adenovirus-mediated E2F-1 gene transfer was used to investigate its effect on human melanoma cell growth.', 'It mentions that E2F-1 overexpression resulted in growth inhibition, loss of cell viability, and ultimately led to apoptotic cell death in both SK-MEL-28 (wild-type p53) and SK-MEL-2 (mutant p53) cell lines.', 'The context provides detailed evidence of apoptosis, including results from cell flow cytometry, cell morphology, in situ terminal deoxynucleotidyl nick end labeling assay, and poly(ADP-ribose) polymerase cleavage assay.', 'The answer accurately reflects the findings in the context, stating that adenovirus-mediated E2F-1 gene transfer efficiently induces widespread apoptosis in human melanoma cells.', 'The answer also correctly notes that this effect does not require wild-type p53 function, as apoptosis was observed in both cell lines with different p53 statuses.'], \"SCORE\": PASS}"
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vllm-91c22c512181436ebcaf88f1b0ab4345 | 21381010 | {
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"content": "{\"REASONING\": ['The context indicates that TRAIL expression in the tumor microenvironment is significantly associated with increased recurrence-free survival in prostate cancer patients.', 'The context specifies that elevated TRAIL expression in the stromal tumor microenvironment is linked to better recurrence-free survival, with a P-value of .014.', 'The answer correctly states that TRAIL expression in the tumor microenvironment may affect recurrence-free survival rates, which aligns with the context.', 'The answer also mentions that the results may be useful in devising future therapeutic strategies, which is a reasonable inference based on the context.'], \"SCORE\": PASS}"
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vllm-7ae594f50d904319a0c75e3b2eac8e23 | 19468252 | {
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"model": "llama-3-70b",
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"content": "{\"REASONING\": ['The QUESTION asks if B-cell translocation gene 2 (BTG2) is over-expressed in peri-infarct neurons after ischaemic stroke.', 'The CONTEXT provides detailed information about the expression of BTG2 in various regions of the brain after a stroke.', 'The CONTEXT states that BTG2 is strongly expressed in peri-infarcted and infarcted regions of brain tissue, and it is localized in neuronal nuclei and cytoplasm.', 'The CONTEXT also mentions that BTG2 is absent or very weakly expressed in normal-looking contralateral tissue.', 'The ANSWER states that BTG2 is over-expressed in peri-infarct neurons and suggests that it may be a modulator of cell survival and differentiation.', 'The ANSWER is faithful to the CONTEXT because it accurately reflects the information provided about the over-expression of BTG2 in peri-infarct neurons and its potential role in cell survival and differentiation.'], \"SCORE\": PASS}"
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vllm-9528188ed9ea40168fecffa0836e01e9 | 20164810 | {
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"content": "{\"REASONING\": ['The context describes a study examining the effects of quadriceps muscle fatigue on muscle activation and performance during a weight-bearing task.', 'The study involved measuring knee motion and muscle activity while subjects performed a resisted single leg squat task with random perturbations.', 'Results showed that muscle fatigue increased the amplitude of the long-latency response in the vastus lateralis muscle.', 'Changes in tracking error occurred after fatigue, despite increased quadriceps muscle activity.', 'The answer accurately reflects the findings that quadriceps muscle fatigue alters muscle activity patterns and may impair performance during weight-bearing tasks.'], \"SCORE\": PASS}"
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vllm-3e18862155aa4b8a8e1c7652bfb28545 | 19127288 | {
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"model": "llama-3-70b",
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"message": {
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"content": "{\"REASONING\": ['The QUESTION asks whether two host factors regulate the persistence of H7-specific T cells injected in tumor-bearing mice.', 'The CONTEXT provides detailed information about the behavior of H7-specific T cells in tumors and mentions that two host factors regulate the long-term persistence of these T cells: thymic function and the expression of H7(a) by host cells.', 'The ANSWER does not directly address the regulation of persistence by these two host factors. Instead, it discusses the general potential of adoptive T cell transfer and the advantages of targeting MiHAs for prolonged persistence.', 'The ANSWER does not faithfully respond to the QUESTION because it does not specifically explain how thymic function and H7(a) expression by host cells regulate the persistence of H7-specific T cells.'], \"SCORE\": FAIL}"
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vllm-b2b39c7653e4409291bd026d398fd7e3 | 26852107 | {
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"content": "{\"REASONING\": ['The context discusses the role of volumetric breast density (VBD) in predicting cosmetic outcomes at the late stage after breast-conserving therapy (BCT).', 'It mentions that there is little research on breast density as a predictor of cosmetic outcomes at the late stage after BCT, but the study evaluated the correlation of VBD and cosmetic outcome.', 'The context provides data from multivariate analysis showing that VBD was a predictor of cosmetic outcome after BCT, particularly when combined with percent breast volume excised (PBVE).', 'The context specifies that VBD was associated with cosmetic outcome at the late stage, while PBVE was involved in the early stage.', 'The answer correctly summarizes that VBD is essential for predicting cosmetic outcome at the late stage after BCT and that a combination of VBD and PBVE could predict cosmetic outcome.'], \"SCORE\": PASS}"
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vllm-40d7465cc7f44b56844112a0e18ce87c | 9758028 | {
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{
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"message": {
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"content": "{\"REASONING\": ['The context describes a study that evaluated the effect of partial liquid ventilation (PLV) on lung albumin leak in the setting of acute lung injury.', 'The study involved five experimental groups, including groups that received PLV before or after lung injury, and measured the amount of albumin leak.', 'The results showed a significant decrease in albumin leak in all groups compared to the control group with lung injury only (CVF only).', 'Specifically, the groups that received PLV (PLV-CVF and CVF-PLV) had significantly lower albumin leak compared to the CVF only group.', 'The answer correctly summarizes that intratracheal instillation of perfluorocarbon (used in PLV) before or after induction of lung injury results in a reduction in pulmonary albumin leak.'], \"SCORE\": PASS}"
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vllm-8d0adbd83ebd4dc7863b74bd6621cdee | 11189197 | {
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"content": "{\"REASONING\": ['The context describes experiments performed on 20-wk-old SHR and WKY rats to determine PGH synthase-1 expression and vascular smooth muscle sensitivity to PGH2.', 'It mentions that under control conditions, acetylcholine did not cause contractions in rings with or without endothelium.', 'However, in the presence of nitro-L-arginine (NLA), acetylcholine evoked endothelium-dependent contraction in SHR but not in WKY aortas.', 'The context also states that PGH synthase-1 expression was comparable in both SHR and WKY aortas.', 'PGH2 caused greater contractions in SHR aortas than in WKY aortas, indicating increased sensitivity to PGH2 in SHR.', 'The answer correctly summarizes that increased response to PGH2 precedes changes in PGH synthase-1 expression in the SHR aorta, as the increased sensitivity to PGH2 is observed without a corresponding increase in PGH synthase-1 expression.'], \"SCORE\": PASS}"
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vllm-725df16c1efa4d55b30ad477d9132f96 | 17577119 | {
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"content": "{\"REASONING\": ['The context states that serum ATX activity and plasma LPA levels were measured in patients with chronic hepatitis C.', 'The results showed that both serum ATX activity and plasma LPA levels were significantly increased in these patients.', 'The increased levels of ATX and LPA were correlated with serum hyaluronic acid and negatively correlated with platelets, albumin, and prothrombin time.', 'There were significant correlations between the histologic stage of fibrosis and both the serum ATX activity and plasma LPA level.', 'The answer accurately reflects the findings mentioned in the context, confirming that both plasma LPA and serum ATX levels are increased in chronic hepatitis C.'], \"SCORE\": PASS}"
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vllm-a36188a5e8904b73a9802db644c8f67b | 21740135 | {
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"content": "{\"REASONING\": ['The context describes the development of two new cyanide antidotes, cobinamide and sulfanegen, which can be administered intramuscularly.', 'The context mentions that the combination of these drugs was tested in mouse models of cyanide poisoning, including non-lethal and lethal models.', 'The results showed that the combination of the two drugs is at least additive, with significant improvements in survival rates compared to using either drug alone.', 'Specifically, the combination yielded 80% survival in the injection model and 40% survival in the inhalation model, where all animals would have died with either drug alone.', 'The context also notes that lower doses of the combined drugs resulted in 80% and 100% survival in the injection and inhalation models, respectively, where only 40% survival was achieved with individual drugs.', 'The context concludes that the combination of cobinamide and sulfanegen shows great promise for treating cyanide poisoning, which aligns with the answer.'], \"SCORE\": PASS}"
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vllm-8440610a2b304b939410836ad3fb3929 | 22491550 | {
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"content": "{\"REASONING\": ['The context describes a study where rats were subjected to a two-hit model of traumatic hemorrhage/resuscitation and endotoxemia, which caused severe lung injury.', 'The study included a group of rats treated with platonin in addition to the two-hit model, and the results showed that the levels of lung injury were significantly lower in this group compared to the group without platonin.', 'Specifically, the context mentions that the levels of functional and histologic alteration, neutrophil infiltration, and concentrations of inflammatory molecules and malondialdehyde were significantly lower in the group treated with platonin.', 'This indicates that platonin mitigated the lung injury caused by the two-hit model, supporting the answer that platonin does mitigate lung injury in this context.'], \"SCORE\": PASS}"
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vllm-4996c4c33b5e470990738392a86aef43 | 15234290 | {
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"content": "{\"REASONING\": ['The QUESTION asks if the classification of Farnsworth-Munsell 100-hue test results is related to the early treatment diabetic retinopathy study.', 'The CONTEXT provides detailed information about the Early Treatment Diabetic Retinopathy Study (ETDRS) and the use of the Farnsworth-Munsell 100-hue test in this study.', 'The CONTEXT mentions that the Farnsworth-Munsell 100-hue test was administered to ETDRS patients and that the results were classified using cluster analysis, which identified thirteen distinct patterns of color vision defects.', 'The ANSWER states that cluster analysis of FM 100-hue test results has found 13 patterns of impaired hue discrimination, which is helpful in understanding color vision defects in diabetes mellitus.', 'The ANSWER is faithful to the CONTEXT because it accurately reflects the information provided about the classification of Farnsworth-Munsell 100-hue test results in the ETDRS.'], \"SCORE\": PASS}"
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"content": "{\"REASONING\": ['The context states that tsTGF-β1 is increased in patients with Marfan syndrome (MFS) and mentions that it has not been assessed in thoracic aortic aneurysm and dissection (TAAD), Loeys-Dietz syndrome (LDS), and bicuspid aortic valve disease (BAVD).', 'However, the context also provides additional information that tsTGF-β1 is increased in genetic aortic syndromes including TAAD, LDS, MFS, and BAVD.', 'The context includes data from a study measuring tsTGF-β1 levels in patients with suspected or known genetic aortic syndrome, which included TAAD, LDS, MFS, and BAVD.', 'The study found that elevated tsTGF-β1 levels were associated with genetic aortic syndrome and that tsTGF-β1 levels were elevated in specific genetic conditions such as MFS and BAVD.', 'The answer correctly summarizes that tsTGF-β1 is elevated in the entire spectrum of genetic aortic syndromes, which aligns with the information provided in the context.'], \"SCORE\": PASS}"
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vllm-e1f2fe844a7e4b07955f62b7a6d675f6 | 15510613 | {
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"content": "{\"REASONING\": ['The context states that the MTHFR C677T and TS tandem repeat polymorphisms were investigated in a case-control study.', 'The study found that these polymorphisms were not associated with a significantly increased risk of breast cancer.', 'No associations were observed with any pathological or molecular feature of the disease.', 'Neither polymorphism was associated with survival from breast cancer.', 'The answer accurately reflects these findings by stating that the common MTHFR C677T and TS enhancer region polymorphisms were not risk factors for breast cancer in this patient cohort nor were they associated with phenotypic features or with prognosis.'], \"SCORE\": PASS}"
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"content": "{\"REASONING\": ['The context describes a study where pretransplant administration of a single donor class I major histocompatibility complex (MHC) molecule, Kb, led to the long-term survival of fully allogeneic cardiac allografts.', 'The study found that pretreatment with CBK bone marrow cells, which express Kb, resulted in the acceptance of cardiac allografts that also expressed Kb, but not those that did not express Kb.', 'The context also mentions that recipients with long-term surviving grafts bearing Kb could accept third-party grafts indefinitely, indicating tolerance to other alloantigens expressed by the transplanted heart.', 'The term \"linked epitope suppression\" refers to the phenomenon where tolerance to one epitope (in this case, Kb) leads to tolerance to other epitopes linked to it.', 'The data provided in the context support the concept of linked epitope suppression, as the tolerance induced by Kb pretreatment extends to other alloantigens expressed by the graft.', 'Therefore, the answer stating that these data provide clear evidence for linked epitope suppression in the induction of operational tolerance in vivo is faithful to the context.'], \"SCORE\": PASS}"
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vllm-9fd19462ba444c84bfd1067889b1bd28 | 16962471 | {
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"content": "{\"REASONING\": ['The CONTEXT describes changes in the extracellular matrix (ECM) volume and collagen composition after prolonged LVAD support.', 'The ECM volume initially increases in the first 200 days, then decreases between 200-400 days, and finally decreases further after 400 days.', 'The CONTEXT mentions an augmented synthesis of collagen during the first month after LVAD support, indicated by increased plasma PINP and PIIINP levels.', 'The CONTEXT also notes that the quality of the collagen network improves over time.', 'The ANSWER accurately reflects these findings by describing a biphasic pattern: an initial increase in collagen turnover and ECM volume, followed by a decrease in turnover and ECM volume, resulting in a restored collagen network.'], \"SCORE\": PASS}"
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vllm-9112be28a7d74725880a790abf74f38d | 20065626 | {
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"content": "{\"REASONING\": ['The context describes a study designed to examine the efficacy of vitamin E in preventing aortic fatty lesion formation in orchidectomized (Orx) aged rats.', 'The study involved feeding Orx rats different doses of vitamin E (75 IU, 250 IU, and 500 IU) and measuring various indices including serum total cholesterol, superoxide dismutase, and atherosclerotic lesion formation.', 'The results showed that the highest dose of vitamin E (500 IU) significantly reduced serum total cholesterol, increased superoxide dismutase, and reduced atherosclerotic lesion formation and aortic fatty streak area by 93% compared to Orx controls.', 'The answer states that vitamin E dose-dependently reduces aortic fatty lesion formation in Orx aged rats, which is supported by the context showing a significant reduction in lesion formation at the highest dose of vitamin E.', 'The answer also mentions the need for clinical studies to confirm these findings in older men with low testosterone levels, which is a reasonable extension based on the context.'], \"SCORE\": PASS}"
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"content": "{\"REASONING\": ['The CONTEXT discusses a study on the relationship between prenatal exposure to organochlorines (OCs) and the occurrence of otitis media (OM) among Inuit children in Greenland.', 'The study found no association between prenatal OC exposure and the development of OM.', 'The CONTEXT also mentions that factors associated with the child’s hazard of OM include the mother’s smoking habits, with both current and previous smoking increasing the risk.', 'The ANSWER correctly states that there is no relationship between high levels of prenatal exposure to OCs and the occurrence of OM.', 'The ANSWER also identifies passive smoking as the strongest environmental risk factor for the development of OM, which is supported by the CONTEXT.', 'Therefore, the ANSWER is faithful to the CONTEXT given the QUESTION.'], \"SCORE\": PASS}"
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vllm-a7590e67c91943d6b1080455b189dc20 | 23544041 | {
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"content": "{\"REASONING\": ['The CONTEXT provides detailed information about the study conducted on community-dwelling people with Parkinson's disease (PWP) to identify determinants of nutritional status.', 'The study found that 15% of the participants were malnourished, and malnutrition was associated with older age, more severe disease, higher UPDRS II and III scores, higher levodopa equivalent daily dose (LEDD)/body weight, lower STAI score, and higher BDI score.', 'The ANSWER states that markers of disease severity are associated with malnutrition in Parkinson's disease, which aligns with the findings in the CONTEXT.', 'The ANSWER also mentions that nutrition screening should occur regularly in those with more severe disease and depression, which is consistent with the CONTEXT where higher UPDRS III scores and higher BDI scores were significant predictors of malnutrition.', 'The CONTEXT also indicates that living alone and higher BDI and UPDRS III scores were significant predictors of a higher log-adjusted PG-SGA score, which supports the ANSWER\\'s suggestion for community support for PWP living alone.', 'The review of dopaminergic medication with body weight changes is also supported by the CONTEXT, where LEDD/body weight was a significant predictor of malnutrition.'], \"SCORE\": PASS}"
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vllm-f8c77eab01df4f43b893e58641c0ab9d | 19053924 | {
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"content": "{\"REASONING\": ['The CONTEXT indicates that endotoxin/LPS levels increased directly with triglyceride and troponin levels and inversely with HDL levels.', 'The ANSWER correctly states that there were associations between endotoxin/LPS and levels of serum triglycerides, troponin, and HDL.', 'The CONTEXT also mentions that subjects with ACS or angina had more alveolar bone loss compared to subjects with chest pain, which aligns with the ANSWER mentioning more alveolar bone loss in patients with cardiac disease.', 'The CONTEXT does not support the claim that there was no difference between the groups in the serum levels of endotoxin/LPS or IgG antibody to P. gingivalis. In fact, the CONTEXT states that endotoxin/LPS and IgG antibody to P. gingivalis tended to increase in association with increased radiographic bone loss in all subjects.'], \"SCORE\": FAIL}"
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vllm-3a02946037b345df9e3c206d22af0459 | 16186269 | {
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"content": "{\"REASONING\": ['The context states that stressful life events have been shown to be a risk factor for type 1 diabetes during childhood.', 'The study aimed to investigate if mothers\\' experiences of serious life events were associated with diabetes-related autoimmunity in their children.', 'The study found that mothers\\' experiences of divorce and violence were associated with diabetes-related autoimmunity in the children, independent of a family history of type 1 diabetes.', 'The answer correctly summarizes these findings by stating that maternal experiences of serious life events seem to be involved in the induction or progression of diabetes-related autoimmunity in children.'], \"SCORE\": PASS}"
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vllm-ef856d57d9144a4d9e80c111013d761f | 21185397 | {
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"content": "{\"REASONING\": ['The CONTEXT provides data on attendance and diagnostic yield for both 1-sample and 2-sample FIT screening.', 'Attendance rates are reported as 61.5% for the 1-sample group and 61.3% for the 2-sample group, with a P-value of .84, indicating no significant difference in attendance between the two groups.', 'The CONTEXT also shows that the diagnostic yield (detection rates for advanced neoplasia) is higher in the 2-sample group compared to the 1-sample group.', 'The ANSWER correctly states that there is no difference in attendance between the two groups and mentions the potential for developing efficient FIT screening strategies, which aligns with the data provided in the CONTEXT.'], \"SCORE\": PASS}"
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vllm-552517892ce74b7792557ed56e4a5560 | 25520328 | {
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"content": "{\"REASONING\": ['The CONTEXT provides detailed information about the factors associated with CPR duration in patients who do not experience ROSC.', 'It specifically mentions that younger age and female sex are associated with longer CPR duration in patients who do not experience ROSC.', 'The CONTEXT also notes that these factors (age and sex) are associated with CPR duration only in patients who do not experience ROSC, not in those who do.', 'The ANSWER accurately reflects this information by stating that age and sex are associated with attempted CPR duration in patients who do not experience ROSC.', 'Therefore, the ANSWER is faithful to the CONTEXT given the QUESTION.'], \"SCORE\": PASS}"
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vllm-690f6a6e04fa4a2a85fe48d40122df9f | 27821059 | {
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{
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"content": "{\"REASONING\": ['The context describes a study on the repetitive fraction of the genome of Taraxacum officinale, focusing on transposable elements (TEs) and their potential role in genomic divergence in asexual species.', 'The study found a highly heterogeneous TE compartment, with recent and potentially ongoing activity of TE families, indicating a dynamic TE landscape.', 'The context mentions that the five accessions are divided into two main clades based on their TE composition, with one clade being more dynamic than the other.', 'It also notes that there are accession-specific TE families that are differentially transcribed and differentially methylated, which could lead to changes in expression of nearby coding sequences.', 'The answer summarizes these findings by stating that the dynamic repetitive compartment enhances divergence within the asexual lineage and speculates that TE-induced mutations could affect functional genes during asexual genome evolution.', 'Therefore, the answer is faithful to the context as it accurately reflects the findings and implications discussed in the provided text.'], \"SCORE\": PASS}"
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vllm-66ce37d415d549d3987f2014b0236b4b | 20657867 | {
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"content": "{\"REASONING\": ['The CONTEXT describes a study that cultured human preosteoblasts in both 3D rotary wall vessels and 2D tissue culture plates.', 'The study found that cells from 3D rotary wall vessel cultures attached to implant surfaces and showed similar growth patterns to 2D cultured cells.', 'The 3D cultured cells and osseous tissues retained higher amounts of mineral formed during the initial culture and showed a higher tendency toward mineralization on implant surfaces.', 'The 3D cultured cells and osseous tissues on implant surfaces at 1 week showed higher key gene protein expression.', 'The ANSWER states that culture of human osteogenic cells and tissues in 3D rotary wall vessels may expedite the osseointegration process on dental implant surfaces, thus reducing the overall treatment time.', 'The ANSWER is consistent with the findings in the CONTEXT, which suggest that 3D cultured cells have advantages in terms of mineralization and gene expression, which are important for osseointegration.'], \"SCORE\": PASS}"
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vllm-6d0d10599d64411ea2e0a7a4aebf77d0 | 15749040 | {
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"message": {
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"content": "{\"REASONING\": ['The context describes a study that measured neutrophil activation by assessing CD11b expression in different blood vessels during AAA repair.', 'The study found that neutrophil CD11b expression was significantly higher in the femoral vein compared to the portal vein and systemic circulation during both ischaemia and reperfusion.', 'This increased CD11b expression in the femoral vein suggests that neutrophil activation occurs specifically in the lower-limbs.', 'The answer correctly interprets the context by stating that neutrophil activation occurs in the lower-limbs, as evidenced by the increased CD11b expression in the femoral vein.'], \"SCORE\": PASS}"
},
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"finish_reason": "stop",
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vllm-ede71dad68844de8bc491be0e6b5ca6b | 15958363 | {
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"content": "{\"REASONING\": ['The CONTEXT provides detailed information about a study comparing cytokine gene expression in patients with aortic stenosis (AS) and idiopathic dilated cardiomyopathy (DCM).', 'The study found that TNFalpha gene expression was significantly higher in AS than in DCM (p = 0.009).', 'The ANSWER states that TNFalpha gene expression is significantly higher in patients with pressure overload (AS) than in patients with idiopathic DCM, which aligns with the findings in the CONTEXT.', 'The ANSWER also mentions that proinflammatory cytokine gene expression did not affect systolic performance in patients with AS, which is supported by the CONTEXT.', 'The CONTEXT notes that higher TNFalpha gene expression in patients with compensated heart failure suggests an adaptive role in the early phase of LV remodelling, which is also mentioned in the ANSWER.'], \"SCORE\": PASS}"
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vllm-b5ca7b6efccc4b3db55f129fa3fe73cc | 25806553 | {
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"choices": [
{
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"message": {
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"content": "{\"REASONING\": ['The CONTEXT provides estimates of the economic consequences of not treating ADHD in Brazil and the potential savings if treatment with MPH-IR is offered.', 'It states that Brazil is probably wasting approximately R$ 1.841 billion/year due to not treating ADHD and that treating ADHD according to WHO recommendations would save around R$ 1.163 billion/year.', 'The ANSWER suggests that by investing R$ 377 million/year in MPH-IR treatment, the country would save approximately 3.1 times more than is currently spent on the consequences of not treating ADHD.', 'The CONTEXT does not provide a direct calculation or mention a specific return on investment (ROI) of 3.1 times more in savings compared to the investment.', 'The ANSWER introduces a new calculation (3.1 times more in savings) that is not explicitly supported by the data provided in the CONTEXT.'], \"SCORE\": FAIL}"
},
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"finish_reason": "stop",
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"completion_tokens": 188
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vllm-262252bc664a45138e43391e81011c92 | 20950982 | {
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"model": "llama-3-70b",
"choices": [
{
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"message": {
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"content": "{\"REASONING\": ['The context states that patients with higher blood glucose levels on admission had a higher rate of angioembolization.', 'The context mentions that the study aimed to define the characteristics of patients with stable pelvic fracture requiring angioembolization.', 'The context provides data from a retrospective review of patient charts, which included analysis of blood glucose levels on admission.', 'The answer accurately reflects the information in the context by stating that higher blood glucose levels on admission are associated with a higher likelihood of needing angioembolization.'], \"SCORE\": PASS}"
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"finish_reason": "stop",
"stop_reason": null
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vllm-1257e8d1d7964bc69c4b33068896c1f8 | 20670777 | {
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"content": "{\"REASONING\": ['The context describes a study on the effect of extracorporeal shock wave therapy on promoting lymphangiogenesis and improving secondary lymphedema.', 'The study used a rabbit ear model of lymphedema and treated the lymphedematous ear with low-energy shock waves.', 'Western blot analysis showed a significant increase in the expression of vascular endothelial growth factor (VEGF)-C and VEGF receptor 3 (VEGFR3) in the shock wave-treated ears compared to the untreated ears.', 'The thickness of the lymphedematous ears decreased significantly with shock wave treatment.', 'Immunohistochemistry for VEGFR3 showed a significant increase in the density of lymphatic vessels with shock wave treatment.', 'These findings suggest that extracorporeal shock wave therapy promotes lymphangiogenesis and ameliorates secondary lymphedema, supporting the answer.'], \"SCORE\": PASS}"
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vllm-18ebe99c17fc478c9dfb87f8b4f8f300 | 18355778 | {
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"content": "{\"REASONING\": ['The context describes how Notch1 signaling regulates the epithelial-mesenchymal transition (EMT) and invasion of breast cancer cells.', 'It mentions that Notch1 silencing reverses the EMT process and inhibits the migration and invasion of breast cancer cells.', 'The context also explains that Notch1 signaling promotes the EMT process, migration, and invasion of breast cancer cells, and that this is mediated by the positive regulation of Slug expression.', 'The knockdown of Slug is shown to weaken the invasion ability of breast cancer cells and reverse the Jagged1-induced EMT process.', 'Slug overexpression is also shown to restore the Notch1 knockdown-suppressed EMT process.', 'Therefore, the answer accurately reflects the information provided in the context, indicating that Notch1 signaling regulates the EMT and invasion of breast cancer in a Slug-dependent manner.'], \"SCORE\": PASS}"
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"content": "{\"REASONING\": ['The CONTEXT provides detailed information on the evaluation of the MELD and MELDNa models for predicting 90-day wait-list mortality.', 'The area under the ROC curve for MELD was 0.887, indicating very good accuracy of discrimination.', 'The area under the ROC curve for MELDNa was 0.848, also indicating good accuracy of discrimination.', 'The observed incidence of 90-day wait-list mortality was not significantly different from the estimates provided by both models.', 'Global goodness-of-fit testing found no evidence of significant lack of fit for either model.', 'Based on these metrics, the ANSWER correctly states that both MELD and MELDNa accurately predicted 90-day wait-list mortality and are generalizable to Atlantic Canadians with end-stage liver disease awaiting liver transplantation.'], \"SCORE\": PASS}"
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"content": "{\"REASONING\": ['The context provides information about two theories on the origin of motion sickness: the sensory conflict theory and the postural instability theory.', 'The context mentions that people with motor-complete spinal cord injury cannot control their muscles below the level of the spinal lesion, leading to a prediction that susceptibility to motion sickness would be higher in these individuals.', 'The context states that 21 people with chronic spinal cord injury completed a questionnaire to compare susceptibility to motion sickness before and after injury.', 'The results indicated that spinal cord injury, regardless of level, did not produce an increase in susceptibility to motion sickness.', 'The answer correctly reflects the findings from the context, stating that there was no increase in motion sickness susceptibility despite the loss of postural control.'], \"SCORE\": PASS}"
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vllm-c9393f2ff8f34d40a8fe80687312057e | 11350093 | {
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"content": "{\"REASONING\": ['The context discusses a study that hypothesized a potential association between the C825T polymorphism in the G-protein beta3 subunit and coronary artery vasomotion.', 'The study found that subjects with at least one T allele had greater susceptibility to vasoconstriction in response to a vasoconstrictor compared to those with the CC genotype.', 'The context does not explicitly state that the polymorphism is associated with coronary artery vasoconstriction, but it suggests that it may modify coronary vasomotion.', 'The answer states definitively that the C825T polymorphism may be a genetic determinant of coronary artery vasomotion, which aligns with the findings in the context.'], \"SCORE\": PASS}"
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"content": "{\"REASONING\": ['The CONTEXT provides a comparison of oncological outcomes between extravesical and endoscopic bladder cuff management during nephroureterectomy for upper urinary tract urothelial cancer.', 'It mentions that the oncological outcome varies based on the location of the upper urinary tract tumor.', 'Specifically, the CONTEXT states that endoscopic bladder cuff management for low ureteral tumors is associated with more bladder tumor recurrence.', 'The ANSWER correctly reflects this by stating that there are similar oncological outcomes for tumors above the low ureter but a higher incidence of bladder tumor recurrence for low ureteral tumors with endoscopic management.', 'Therefore, the ANSWER is faithful to the CONTEXT given the QUESTION.'], \"SCORE\": PASS}"
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"content": "{\"REASONING\": ['The context describes the effects of silencing PINK1 expression in human dopaminergic cells.', 'It mentions that silencing PINK1 leads to a decrease in mtDNA levels and mtDNA synthesis.', 'The context also reports a concomitant loss of mitochondrial membrane potential and decreased mitochondrial ATP synthesis, with complex IV of the ETC being most affected.', 'These findings indicate that silencing PINK1 affects both mitochondrial DNA and oxidative phosphorylation in dopaminergic cells.', \"The answer states that silencing PINK1 expression affects mitochondrial DNA and oxidative phosphorylation, which is consistent with the details provided in the context.\"], \"SCORE\": PASS}"
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"content": "{\"REASONING\": ['The context describes a study where the arginase inhibitor Nw-hydroxy-nor-L-arginine (nor-NOHA) was used to treat adjuvant-induced arthritis (AIA) rats.', 'The study found that nor-NOHA treatment fully restored the aortic response to acetylcholine (Ach) to that of healthy controls, indicating a restoration of endothelial function.', 'The beneficial effects of nor-NOHA were mediated by increased nitric oxide synthase (NOS) activity, endothelium-derived hyperpolarizing factor (EDHF), and reduced superoxide anion production, as well as decreased activity of cyclooxygenase (COX)-2, thromboxane, and prostacyclins synthases.', 'The context also mentions that nor-NOHA decreased plasma levels of IL-6 and vascular endothelial growth factor (VEGF) in AIA rats.', 'The answer correctly states that the treatment with the arginase inhibitor restores endothelial function in AIA rats and suggests its potential as a novel add-on therapy in the treatment of rheumatoid arthritis (RA).'], \"SCORE\": PASS}"
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"content": "{\"REASONING\": ['The context describes a study investigating the role of sphingosine-1-phosphate (S1P) in regulating photoreceptor proliferation and differentiation.', 'It mentions that S1P increased the proliferation of photoreceptor progenitors and stimulated the formation of apical processes, enhanced opsin and peripherin expression, and promoted their localization in these processes.', 'The context also notes that GDNF and DHA enhanced SphK expression in photoreceptors, and inhibiting S1P synthesis blocked GDNF mitogenic effects and DHA effects on differentiation.', 'The answer summarizes these findings by stating that S1P is a key regulator in photoreceptor development and that GDNF and DHA might upregulate SphK levels to promote S1P synthesis, which would initially promote proliferation and then advance photoreceptor differentiation.', 'Therefore, the answer is faithful to the context provided.'], \"SCORE\": PASS}"
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vllm-4d51785ea4b34c1d9e376eb08bbce5ad | 16460692 | {
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"content": "{\"REASONING\": ['The context describes how prenatal stress reduces hippocampal neurogenesis and that these effects can be counteracted by postnatal infantile stimulation.', 'The context specifically mentions that postnatal handling counteracts the deleterious effects of prenatal stress on hippocampal cell proliferation, survival rate of newborn cells, and neuronal differentiation.', 'The answer states that postnatal stimulation can reverse the effects of prenatal stress, which aligns with the context provided.', 'The answer also suggests that infantile stimulation may reverse behavioral disorders induced by early life stress, which is consistent with the context mentioning the prevention of cognitive impairments, mood disorders, and addiction.'], \"SCORE\": PASS}"
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"content": "{\"REASONING\": ['The CONTEXT states that the mass-specific net cost of walking (Cw) was 15% higher in older women compared to younger women.', 'The CONTEXT also mentions that the self-selected walking speed was 23% lower in older women than in younger women.', 'The ANSWER correctly reflects that older women have a higher metabolic cost (energy cost) at their self-selected exercise pace.', 'The ANSWER also aligns with the CONTEXT by implying that this higher metabolic cost should be considered when recommending walking as an exercise modality for older women.'], \"SCORE\": PASS}"
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"content": "{\"REASONING\": ['The context discusses a study examining the associations between employment conditions, work-related stressors, and menopausal symptom reporting among perimenopausal and postmenopausal women.', 'The study found that high supervisor support, full-time employment, and control over workplace temperature were independently associated with lower menopausal symptom reporting.', 'The answer states that employment conditions and work-related stressors are associated with menopausal symptom reporting, which aligns with the findings presented in the context.', \"The answer also mentions that these findings can inform the development of occupational health policies, which is a reasonable implication given the context's discussion of workplace factors.\"], \"SCORE\": PASS}"
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"content": "{\"REASONING\": ['The context describes PARP1 as a chromatin-associated enzyme that regulates chromatin structure and promotes CNS inflammation by facilitating the expression of inflammatory cytokines in glial cells.', 'It mentions that PARP1 enzymatic activity and histone ADP-ribosylation increase the accessibility of nucleosomal DNA, allowing for the recruitment of transcription factors like NF-κB.', 'The context specifies that PARP1 is associated with the Il1β and Tnf promoters, and upon LPS stimulation, ADP-ribosylation occurs, leading to increased NF-κB recruitment and subsequent transcription of these inflammatory cytokines.', 'The context also notes that pharmacological inhibition of PARP1 enzymatic activity reduces NF-κB recruitment and Il1β and Tnf expression in LPS-stimulated microglia.', 'The answer accurately reflects these points by stating that PARP1 facilitates inflammatory cytokine expression in microglia by increasing the accessibility of promoter DNA via histone ADP-ribosylation.'], \"SCORE\": PASS}"
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vllm-88ddf18777ab4e3abb9d8f960ac447e9 | 22040499 | {
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"content": "{\"REASONING\": ['The CONTEXT discusses the identification of the FATS gene and its role in breast cancer.', 'It mentions that the study aimed to determine the role of FATS in breast cancer development and its clinical significance.', 'The CONTEXT provides data on the expression level of FATS mRNA in breast carcinomas and normal tissues, showing that it is down-regulated in breast cancer.', 'It also states that low expression of FATS is associated with poor outcomes in node-positive breast cancer patients, while high expression is associated with a favorable outcome.', 'The ANSWER summarizes that FATS is involved in breast cancer development and could be a potential biomarker and prognostic factor, which aligns with the findings and conclusions presented in the CONTEXT.'], \"SCORE\": PASS}"
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"content": "{\"REASONING\": ['The CONTEXT provides detailed information about a study investigating the effects of peri-procedural statin medication on platelet aggregation and clinical outcomes in patients undergoing coronary intervention.', 'The study found that residual platelet activity was not significantly influenced by statin treatment.', 'There was even a trend towards lower residual platelet activity (RPA) values in patients treated with CYP3A4-metabolized statins.', 'The study also found no significant adverse effects of statin treatment on clinical outcomes, and statin treatment was independently associated with a lower incidence of composite events.', 'The ANSWER accurately reflects these findings by stating that peri-procedural co-administration of statins does not increase post-interventional RPA and does not worsen clinical prognosis.'], \"SCORE\": PASS}"
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"content": "{\"REASONING\": ['The context provides data from a study on 32 children with immune thrombocytopenic purpura (ITP).', 'The study found that 21 out of 23 patients who had a good or excellent response to IVIG also had an excellent response to splenectomy.', 'Additionally, 6 out of 9 patients who had a poor response to IVIG also had a poor response to splenectomy.', 'The context states that response to IVIG was a sensitive predictor of response to splenectomy in 88% of patients, with a specificity of 75%, a positive predictive value of 91%, and a negative predictive value of 67%.', 'Based on these findings, the answer that response to IVIG predicts response to splenectomy in children with chronic ITP is supported by the context.'], \"SCORE\": PASS}"
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vllm-0917d97833334bd2b73c8635bcc8a902 | 25268673 | {
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"content": "{\"REASONING\": ['The context provides evidence that annexin A8 (A-A8) is overexpressed in pancreatic cancer cells and is associated with poor prognosis.', 'The study found that increased A-A8 expression is correlated with higher tumor grades and decreased 5-year survival.', 'The context also shows that A-A8 knockdown in pancreatic cancer cells leads to decreased cell viability, migration, and colony formation, suggesting its role in cancer progression.', 'The answer accurately reflects the findings in the context, supporting the investigation of A-A8 as a prognostic marker and therapeutic target for pancreatic cancer.'], \"SCORE\": PASS}"
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"content": "{\"REASONING\": ['The context describes Rad51 and Dmc1 as homologues of RecA, both required for normal meiotic recombination.', 'It highlights that both proteins have distinct roles, as evidenced by different severity of defects in single mutants: dmc1 mutants have more severe defects in DSB resolution and crossover recombination, while rad51 mutants have more severe defects in viability and intrachromosomal recombination during return to growth.', 'The context also mentions that the double mutant is more defective in crossover formation and interhomologue/intrachromosomal recombination, indicating that both proteins contribute uniquely.', 'The observation of DMC1-dependent recombination in a rad51 mutant suggests that Dmc1 can substitute for Rad51 to some extent, implying overlapping functions.', 'The answer accurately reflects these points by stating that Rad51 and Dmc1 make unique contributions but can substitute for each other under some circumstances, indicating both distinct and overlapping roles.'], \"SCORE\": PASS}"
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"content": "{\"REASONING\": ['The context describes an experiment where fyn knockout (fyn-/-) mice showed increased eosinophil infiltration into the conjunctiva compared to wild-type (WT) mice, indicating that fyn normally regulates this process.', 'The context also mentions that fyn-/- mice had higher levels of IL-4 production, which is a cytokine associated with Th2 responses, suggesting that fyn negatively regulates Th2 responses.', 'The context specifies that this negative regulation occurs during the induction phase of experimental immune-mediated blepharoconjunctivitis (EC).', 'The answer accurately reflects these findings by stating that fyn regulates eosinophil infiltration through downregulation of Th2 responses, specifically during the induction phase.'], \"SCORE\": PASS}"
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"content": "{\"REASONING\": ['The context describes a study where rabbits were infected with either a tPMP-susceptible or a tPMP-resistant Staphylococcus aureus strain to evaluate the influence of tPMP-susceptibility on disease severity in experimental infective endocarditis (IE).', 'The study found significant differences in various parameters between the groups infected with tPMP-susceptible and tPMP-resistant strains, including lower bacteremia rates, reduced vegetation growth and weight, later onset of aortic valvular regurgitation, increased preservation of left ventricular function, reduced valvular tissue damage and perivalvular inflammation, and reduced bacterial densities in vegetations and kidneys.', 'These findings indicate that in vitro susceptibility to thrombin-induced platelet microbicidal protein (tPMP) is associated with reduced disease progression and complication rates in experimental Staphylococcus aureus endocarditis.', 'The answer accurately reflects the findings and conclusions presented in the context, stating that the in vitro tPMP-susceptibility profile substantially affects cardiac and microbiological parameters related to disease severity and prognosis in IE, and that platelets likely mitigate the pathogenesis of endovascular infections via local secretion of antimicrobial peptides.'], \"SCORE\": PASS}"
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vllm-77054189adb74185b681db211c3f8bc1 | 16151723 | {
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"content": "{\"REASONING\": ['The CONTEXT provides detailed information about a study comparing the causative pathogens of early-onset and late-onset ventilator-associated pneumonia (VAP).', 'The study found that potentially multiresistant bacteria were the most commonly isolated pathogens in both early-onset and late-onset VAP.', 'Specifically, the CONTEXT mentions that Pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus (MRSA) were the main pathogens responsible for both types of VAP.', 'The CONTEXT also states that there was no significant difference in the contribution of potentially multiresistant pathogens between early-onset and late-onset VAP (79% vs. 85%).', 'The ANSWER accurately reflects these findings by stating that both early-onset and late-onset VAP were mainly caused by potentially multiresistant bacteria, specifically P. aeruginosa and MRSA.'], \"SCORE\": PASS}"
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"content": "{\"REASONING\": ['The CONTEXT discusses how the host species composition and their relative availability affect the host-feeding choices of Triatoma infestans and parasite transmission risks.', 'The CONTEXT provides data on the main bloodmeal sources for T. infestans, which are humans, chickens, and dogs, and how the presence of chickens and dogs influences the human blood index and daily human-feeding rates.', 'The CONTEXT mentions that blood-feeding rates decrease with increases in the chicken blood index and that the human blood index and daily human-feeding rate decrease with increasing proportions of chicken- or dog-fed bugs.', 'The ANSWER states that domestic animal hosts strongly influence human-feeding rates and that the presence of domestic animals in domiciles profoundly affects host-feeding choices and parasite transmission.', 'The ANSWER also introduces the concept of zoopotentiation, which is not directly supported by the CONTEXT. The CONTEXT does not provide a direct comparison of the infectivity of dogs versus humans or discuss the specific concept of zoopotentiation.', 'Therefore, while the ANSWER is generally consistent with the CONTEXT in terms of the influence of domestic animals on human-feeding rates, it introduces an unsupported concept (zoopotentiation) and does not directly address the QUESTION about the strong influence of domestic animal hosts on human-feeding rates.'], \"SCORE\": FAIL}"
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vllm-5ccdf901f06e4f33a6d58b4a3912f5b0 | 10226343 | {
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"content": "{\"REASONING\": ['The context mentions that ultrasonography was used to study 11 patients with suspected quadriceps tendon rupture.', 'It was possible to confirm the clinical examination results using ultrasonography in 9 out of 11 cases.', 'The context also notes that ultrasonography was useful for postoperative follow-up, with tissue homogeneity and echogeneity normalizing after the sixth week.', 'The answer states that ultrasonography can clearly diagnose quadriceps tendon ruptures and objectively assess postoperative follow-up, which aligns with the context provided.'], \"SCORE\": PASS}"
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"content": "{\"REASONING\": ['The CONTEXT indicates that mediation analyses showed that confrontation coping mediated the association between Type D personality and perceived severity of disease, and acceptance-resignation coping mediated the association between Type D personality and morale.', 'The ANSWER states that maladaptive coping strategies fully mediated the association between Type D personality and perceived health, which is a broader term that encompasses both perceived severity of disease and morale.', 'The CONTEXT does not explicitly state that coping strategies fully mediated the association between Type D personality and perceived health; it only mentions mediation for specific aspects (perceived severity of disease and morale).', 'Therefore, the ANSWER extrapolates beyond the specific findings presented in the CONTEXT and is not faithful to the provided information.'], \"SCORE\": FAIL}"
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vllm-a4b05e722f794b3dbaa962267e694ffb | 18942762 | {
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"content": "{\"REASONING\": ['The context states that butyrate oxidation is significantly impaired in endoscopically active ulcerative colitis (UC) and active pouchitis.', 'It mentions that the severity of the metabolic defect is related to histological disease activity and decreased epithelial cell height in both conditions.', 'The context also notes that butyrate oxidation is significantly decreased in active pouchitis compared to normal ileum and excluded pouches without inflammation.', 'The histological pouchitis score is shown to correlate significantly with butyrate oxidation, indicating a similar metabolic profile to active UC.', 'Therefore, the answer accurately reflects the information provided in the context, stating that active UC and pouchitis show the same inflammation-related metabolic defect and are metabolically similar.'], \"SCORE\": PASS}"
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vllm-3298ae73973d41ba99395eab6bd6e914 | 19250763 | {
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"content": "{\"REASONING\": ['The CONTEXT provides a study comparing the effects of 16 Gy and 20 Gy radiotherapy (RT) on Leydig cell function and testosterone levels in men treated for carcinoma in situ (CIS) of the testis.', 'The study found that men treated with 16 Gy RT had stable testosterone levels, with an annual decrease of only -1.1%, which was not statistically significant (p = 0.4).', 'In contrast, men treated with 20 Gy RT had an annual decrease of 2.4% in testosterone levels, which was statistically significant (p = 0.008).', 'The decrease in testosterone levels was most pronounced in the first 5 years for the 20 Gy group and leveled off during the following 5 years.', 'More men treated with 20 Gy needed androgen substitution treatment compared to those treated with 16 Gy.', 'The CONTEXT also mentions that luteinizing hormone levels increased in the 16 Gy group, although not significantly (p = 0.5), and decreased in the 20 Gy group (-3.1%, p = 0.01).', 'Based on these findings, the ANSWER correctly states that 16 Gy RT better preserves testosterone levels compared to 20 Gy RT, making it preferred from an endocrinological perspective.'], \"SCORE\": PASS}"
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vllm-0b806e0fff17435386c506430dfb8d7a | 17244356 | {
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"content": "{\"REASONING\": ['The context describes a study that examines the influence of emotional facial expression on the N170 response to faces.', 'The study found that the N170 response was strongly modulated by emotional facial expression, specifically showing a significant difference between fear and neutral faces.', 'The effect of emotional modulation was robust and consistent throughout the experiment, and did not interact with the gender of the face stimulus or the hemisphere of recording sites.', 'The topography of the effect suggested that fear stimuli exaggerated the N170 response itself.', 'The answer accurately reflects these findings by stating that the face N170 response can be influenced by emotional expressions and that this finding contrasts with previous models that suggested N170 processes only structural analysis of faces.'], \"SCORE\": PASS}"
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vllm-7fe0008b60a04ba39b90a09bd452600f | 12407146 | {
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"content": "{\"REASONING\": ['The CONTEXT describes the analysis of transcript heterogeneity in the RPGR gene.', 'It mentions that RPGR transcripts can terminate at different sites, leading to numerous variants.', 'The CONTEXT specifically highlights the presence of multiple exonic splicing enhancers (ESEs) in a purine-rich region, which are known to promote splicing through interaction with serine-arginine repeat (SR) proteins.', 'The ANSWER states that the heterogeneity in RPGR transcript processing results from alternative RNA splicing mediated by multiple exonic splicing enhancers, which aligns with the information provided in the CONTEXT.', 'The ANSWER also mentions the composition of RPGR proteins, which is consistent with the CONTEXT describing the detection of various RPGR proteins in photoreceptors.'], \"SCORE\": PASS}"
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vllm-9acd9bcd6c5d4b8d8b5ebddc2e42d30e | 20332759 | {
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"content": "{\"REASONING\": ['The context describes a study analyzing the antitumor efficacy of a cancer vaccine therapy combined with vitamin D3 (VD3) for treating Lewis lung carcinoma.', 'The study involved administering cancer vaccines with or without VD3 and/or low-dose cyclophosphamide to mice with Lewis lung carcinoma.', 'The results showed that the combination of the protein-based vaccine with VD3 and cyclophosphamide led to significant suppression of primary tumor growth and had a significant antimetastatic effect.', 'Similarly, the introduction of VD3 with or without cyclophosphamide in the DNA-vaccine treatment regimen resulted in significant suppression of primary tumor and metastasis volumes.', 'The context also mentions that in the prophylactic regimen, significant antimetastatic effects and an elevation of average life-span were observed.', 'The answer states that the administration of VD3 improves the antimetastatic efficacy of cancer vaccine therapy, which is supported by the significant antimetastatic effects reported in the context.'], \"SCORE\": PASS}"
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vllm-ccb65fd28e7746b79ac7aef848e8a53a | 27059776 | {
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"content": "{\"REASONING\": ['The context describes a study that evaluates the impact of damaging the plasma membrane and acrosome of spermatozoa on sheep embryonic development during ICSI.', 'The study found that injecting oocytes with piezo-pulsed spermatozoa (PPS) increased the proportion of zygotes and blastocysts significantly compared to using intact and untreated spermatozoa (CTR-IS).', 'The context also mentions that pre-treating PPS with ionomycin further improved blastocyst development, while pre-treatment with Triton X-100 impeded it.', 'The answer states that mechanically damaging the plasma membrane and acrosome of spermatozoa substantially improves embryonic development until the blastocyst stage, which aligns with the findings in the context.'], \"SCORE\": PASS}"
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vllm-2006129e71814d5d96964520362228a0 | 26898427 | {
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"content": "{\"REASONING\": ['The context describes a study investigating the chemopreventive role of sulforaphane (SFN) in lung cancer cells.', 'The study found that SFN inhibited HDAC activity and increased the levels of acetylated histones H3 and H4 in lung cancer cells.', 'SFN also induced apoptosis, affected cell cycles, and increased apoptosis-related proteins.', 'In an in vivo xenograft mouse model, SFN suppressed lung cancer growth.', 'The answer summarizes these findings by stating that SFN suppresses lung tumorigenesis through the downregulation of HDAC activity, which is consistent with the context.'], \"SCORE\": PASS}"
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vllm-4f1dec8bcb404b86a58a83f7096386c2 | 21573120 | {
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"content": "{\"REASONING\": ['The context describes a study investigating the effects of a TLR2 agonist on neonatal brain development.', 'Mice were injected with a TLR2 agonist, Pam(3)CSK(4), and brain development was assessed.', 'After 9 days of administration, results showed a decreased volume of cerebral gray matter, white matter in the forebrain, and cerebellar molecular layer.', 'Additionally, there was an increase in spleen and liver weight, decreased hippocampus neuronal density, and increased cerebral microglia density.', 'These effects were not observed in TLR2-deficient mice, indicating that the changes were specifically due to TLR2 stimulation.', 'The context supports the answer that repeated systemic exposure to the TLR2 agonist can have a short-term negative impact on the neonatal mouse brain.'], \"SCORE\": PASS}"
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vllm-57f23d67b2fd44aaad639bcb614c0ce7 | 26936519 | {
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"content": "{\"REASONING\": ['The context describes a post hoc analysis of two phase III clinical trials that investigated the effect of dapagliflozin on albuminuria in patients with type 2 diabetes and hypertension who were already receiving renin-angiotensin blockers.', 'The analysis included patients with microalbuminuria or macroalbuminuria at baseline and compared the effects of dapagliflozin versus placebo.', 'The results showed that dapagliflozin resulted in greater reductions in albuminuria compared to placebo, both in absolute terms (-33.2% vs. placebo) and after adjusting for other factors (-23.5% vs. placebo).', 'The answer accurately reflects these findings by stating that dapagliflozin was effective in lowering albuminuria in these patients.', 'The answer also mentions that the reductions in albuminuria were still present after adjusting for changes in HbA1c, SBP, body weight, and eGFR, which is consistent with the context.', 'The additional information in the answer about potential long-term benefits is supported by the context, which notes improvements in glycaemic control and reductions in SBP, as well as other potentially beneficial renal effects.'], \"SCORE\": PASS}"
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"content": "{\"REASONING\": ['The context describes an investigation into the effects of measles virus vaccine-infected tumor cells on human plasmacytoid dendritic cells (pDC).', 'It is found that measles virus vaccine-infected tumor cells induce pDC maturation and the production of IFN-α.', 'The context specifically mentions that measles virus vaccine-infected tumor cells are phagocytosed by pDC and that this leads to the cross-presentation of the tumor antigen NYESO-1 to a specific CD8(+) T-cell clone.', 'The answer summarizes these findings by stating that measles virus vaccine-infected tumor cells induce tumor antigen cross-presentation by human pDC, which is consistent with the details provided in the context.'], \"SCORE\": PASS}"
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"content": "{\"REASONING\": ['The context provides data on the prevalence of otorrhoea in HIV-infected children and its association with clinical and immune stages.', 'The context mentions that otorrhoea is common in HIV-infected children and provides specific statistics on its prevalence and severity.', 'The context notes that children with otorrhoea have lower median CD4 percentages compared to those without otorrhoea, indicating a relationship with immune depletion.', 'The context also provides odds ratios indicating that severe otorrhoea is more likely in children with advanced HIV disease stages.', 'The answer summarizes these points by stating that otorrhoea is a marker for symptomatic disease and CD4 depletion, which is consistent with the data and analysis provided in the context.'], \"SCORE\": PASS}"
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vllm-d81f08989a354f319845cf2439f5573c | 17934148 | {
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"content": "{\"REASONING\": ['The CONTEXT states that type 2 diabetic patients have, on average, 80% more liver fat than nondiabetic subjects.', 'The CONTEXT also mentions that the difference in liver fat between the two groups remains statistically significant when adjusted for intra-abdominal fat.', 'The CONTEXT specifies that at any given BMI or waist circumference, type 2 diabetic patients have more liver fat than nondiabetic subjects.', 'The CONTEXT notes that the difference in liver fat between the groups increases as a function of BMI and waist circumference.', 'The CONTEXT indicates that the slopes of the relationships between S-ALT and liver fat are significantly different between the two groups, suggesting that S-ALT underestimates liver fat in type 2 diabetic patients.', 'The ANSWER accurately reflects these points by stating that type 2 diabetic patients have 80% more liver fat and that S-ALT underestimates liver fat in these patients.'], \"SCORE\": PASS}"
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vllm-48276b3a64454f5cb511697f6a301932 | 8996501 | {
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"content": "{\"REASONING\": ['The context provides detailed information about a study that evaluated the sensitivity and specificity of a battery of transcranial Doppler ultrasound (TCD) findings in identifying severe internal carotid artery stenosis.', 'The study found that the TCD battery had a sensitivity of 95% and specificity of 42% for identifying carotid stenosis of 70% or greater.', 'The answer states that a battery of TCD findings reliably identified patients with 70% or greater angiographic internal carotid artery stenosis with high sensitivity.', 'The context supports the answer by providing the high sensitivity value of 95% for the TCD battery in identifying severe carotid stenosis.'], \"SCORE\": PASS}"
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vllm-b0b5096f66ed4e5da8b80018166968dd | 17912373 | {
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"content": "{\"REASONING\": ['The context describes genetic code alterations and their effects on the organism Candida albicans.', 'It mentions that genetic code manipulation had profound cellular consequences, including morphological variation, altered gene expression, and changes in cell-cell adhesion and enzyme secretion.', 'The context supports the idea that genetic code alterations can generate phenotypic diversity.', \"The answer states that genetic code alterations are generators of phenotypic diversity and supports the hypothesis that they speed up evolution of new phenotypes, which aligns with the context provided.\"], \"SCORE\": PASS}"
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vllm-7c607ae91607435cb236a126b8195960 | 20549164 | {
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"content": "{\"REASONING\": ['The context indicates that repetitive training of complex upper limb movements with a focus on strength and velocity as shaping elements is effective in stroke rehabilitation.', 'The study found continuous functional improvement in patients, with significant improvements in voluntary forces during the first training phase.', 'Specific movements like sawing and grasping and transport movements improved significantly during the phases where shaping elements were used.', 'The answer correctly states that repetitive training of complex movements results in motor improvement, but it also mentions that there is no relevant transfer to functional improvement if strength and velocity are to be enhanced as shaping elements.', 'This addition about the lack of functional improvement is not supported by the context, which only mentions continuous functional improvement and significant improvements in specific movements.'], \"SCORE\": FAIL}"
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"content": "{\"REASONING\": ['The context provides detailed information about the study conducted on serum SDC-1 levels in patients with SLE, including its association with various clinical manifestations and laboratory variables.', 'It specifically mentions that serum SDC-1 levels were higher in patients with active nephritis compared to those with inactive nephritis and those without nephritis, with p-values indicating statistical significance.', 'The context also states that serum SDC-1 levels were correlated with the renal SLEDAI score and the excretion of proteinuria, further supporting the association with renal involvement.', 'Additionally, the context notes a positive correlation between serum SDC-1 levels and the activity index in patients with lupus nephritis, suggesting that SDC-1 could be a useful biomarker for active LN.', 'The answer accurately reflects the findings presented in the context, stating that elevated serum SDC-1 levels are associated with renal involvement in SLE patients and suggesting its potential as a biomarker for active LN.'], \"SCORE\": PASS}"
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vllm-6da87c56f2af47808ad2e8a096d2c987 | 25157773 | {
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"content": "{\"REASONING\": ['The CONTEXT provides data from a study comparing survival rates between primary esophagectomy and induction therapy followed by esophagectomy for cT2N0 esophageal cancer patients.', 'The study found no significant difference in long-term survival between the two treatment strategies (median 41.1 months vs. 41.9 months, p = 0.51).', 'Multivariable analysis indicated that induction therapy was not independently associated with a reduced risk of death (hazard ratio [HR], 1.16, p = 0.32).', 'The ANSWER correctly states that induction therapy is not associated with improved survival, which aligns with the findings presented in the CONTEXT.'], \"SCORE\": PASS}"
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vllm-1b6ec9398cdc4525b46328fa93f76dcf | 17904063 | {
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"content": "{\"REASONING\": ['The context describes a study investigating the significance of NT-proBNP in predicting outcomes in acute stroke patients.', 'The study found that deceased patients had significantly higher concentrations of NT-proBNP compared to alive patients.', 'Cox regression analysis revealed that NT-proBNP was the most significant independent variable predicting mortality.', 'The answer states that NT-proBNP has independent prognostic value in acute stroke patients, which aligns with the findings in the context.', 'The answer also mentions that this prognostic value is over other cardiovascular variables and stroke severity, which is supported by the context.'], \"SCORE\": PASS}"
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vllm-a9302a705c364aa4be685976b327062c | 27330686 | {
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"content": "{\"REASONING\": ['The CONTEXT describes a study designed to determine the effect of simvastatin on serum Vitamin D levels in dyslipidemic patients.', 'The study was a randomized, double-blind, placebo-controlled, crossover trial involving 102 individuals, with 77 completing the trial.', 'The results showed no significant change in serum Vitamin D levels during simvastatin therapy (P > 0.05).', 'The ANSWER correctly states that short-term treatment with simvastatin (40 mg/day) does not have a significant effect on serum levels of Vitamin D, aligning with the findings presented in the CONTEXT.'], \"SCORE\": PASS}"
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vllm-cfd67794eb6f48938895f4004f2b1cfe | 12438463 | {
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"content": "{\"REASONING\": ['The CONTEXT provides detailed information about the sensitivity of different types of MRI reports in detecting focal lesions in patients with epilepsy.', 'It mentions that the sensitivity of standard MRI reports by non-expert radiologists was 39%, by expert radiologists was 50%, and by dedicated epilepsy MRI was 91%.', 'The CONTEXT also states that dedicated MRI showed focal lesions in 85% of patients with non-lesional standard MRI.', 'The ANSWER correctly summarizes that standard MRI failed to detect a significant percentage of focal epileptogenic lesions, which aligns with the sensitivity figures provided in the CONTEXT.', 'The ANSWER also appropriately concludes that patients with refractory epilepsy should be referred to an MRI unit with epileptological experience early on, which is supported by the CONTEXT.'], \"SCORE\": PASS}"
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vllm-092565618fad46bb9086199caf9b14f8 | 23396543 | {
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"content": "{\"REASONING\": ['The context describes a study where indication-based computer order entry alerts were implemented to intercept wrong-patient medication errors.', 'The study found that over a 6-year period, 127,320 alerts fired, resulting in 32 intercepted wrong-patient errors, which translates to an interception rate of 0.25 per 1000 alerts.', 'The context explicitly states that the indication-based alerts intercepted wrong-patient medication errors, supporting the claim that indication-based prescribing prevents such errors.', \"The answer correctly summarizes that indication alerts linked to the problem list have been shown to improve problem list completion and, as demonstrated in the analysis, intercept wrong-patient medication errors.\"], \"SCORE\": PASS}"
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vllm-ba7b8c1f3da14ad495f386008b7a0057 | 26446484 | {
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"content": "{\"REASONING\": ['The CONTEXT provides data from a study examining the use and potential benefits of chromium supplementation in relation to Type 2 Diabetes (T2D) using NHANES data.', 'The study found that the odds of having T2D were lower in persons who consumed chromium-containing supplements within the previous 30 days compared to those who did not (OR: 0.73; 95% CI: 0.62, 0.86; P = 0.001).', 'The ANSWER states that the odds of having T2D were lower in those who had consumed supplements containing chromium, which aligns with the findings presented in the CONTEXT.', 'The ANSWER also mentions that over one-half of the adult US population consumes nutritional supplements and over one-quarter consumes supplemental chromium, which is consistent with the CONTEXT stating that 58.3% reported consuming a dietary supplement and 28.8% reported consuming a dietary supplement that contained chromium.', 'The suggestion in the ANSWER that studies on safety and efficacy are warranted is a reasonable extension based on the CONTEXT, which implies that further research is needed to fully understand the effects of chromium supplementation.'], \"SCORE\": PASS}"
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