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DS.d303
18539387
[ { "id": "DS.d303.s0", "type": "", "text": [ "Mineralization and dehalogenation of 2,4,6-TCP was evidenced by high COD removal efficiencies (approximately 95%), and by the stoichiometric release of chloride ions from the halogenated compound (approximately 80%)." ], "offsets": [ [ 0, 216 ] ] } ]
[ { "id": "DS.d303.s0.e0", "type": "compound", "text": [ "2,4,6-TCP" ], "offsets": [ [ 37, 46 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6914" } ] }, { "id": "DS.d303.s0.e1", "type": "protein", "text": [ "COD" ], "offsets": [ [ 69, 72 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P14678" } ] }, { "id": "DS.d303.s0.e2", "type": "compound", "text": [ "chloride" ], "offsets": [ [ 152, 160 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "312" } ] } ]
[]
[]
[ { "id": "DS.d303.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d303.s0.e0", "arg2_id": "DS.d303.s0.e1", "normalized": [] } ]
DS.d305
18541345
[ { "id": "DS.d305.s0", "type": "", "text": [ "Gliclazide can change the conformation of the active sites and decrease obviously the affinities between gliclazide in the active site and enzymes when it is docked in the second active sites in CYP2C9 and CYP2C19." ], "offsets": [ [ 0, 214 ] ] } ]
[ { "id": "DS.d305.s0.e0", "type": "compound", "text": [ "Gliclazide" ], "offsets": [ [ 0, 10 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "3475" } ] }, { "id": "DS.d305.s0.e1", "type": "compound", "text": [ "gliclazide" ], "offsets": [ [ 105, 115 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "3475" } ] }, { "id": "DS.d305.s0.e2", "type": "protein", "text": [ "CYP2C9" ], "offsets": [ [ 195, 201 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P11712" } ] }, { "id": "DS.d305.s0.e3", "type": "protein", "text": [ "CYP2C19" ], "offsets": [ [ 206, 213 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P33261" } ] } ]
[]
[]
[ { "id": "DS.d305.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d305.s0.e0", "arg2_id": "DS.d305.s0.e3", "normalized": [] }, { "id": "DS.d305.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d305.s0.e1", "arg2_id": "DS.d305.s0.e2", "normalized": [] }, { "id": "DS.d305.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d305.s0.e0", "arg2_id": "DS.d305.s0.e2", "normalized": [] }, { "id": "DS.d305.s0.i3", "type": "compound-protein-interaction", "arg1_id": "DS.d305.s0.e1", "arg2_id": "DS.d305.s0.e3", "normalized": [] } ]
DS.d306
18543297
[ { "id": "DS.d306.s0", "type": "", "text": [ "Metabolism of dextrorphan by CYP2D6 in different recombinantly expressed systems and its implications for the in vitro assessment of dextromethorphan metabolism." ], "offsets": [ [ 0, 161 ] ] }, { "id": "DS.d306.s1", "type": "", "text": [ "Cytochrome P450 2D6 (CYP2D6) mediated formation of dextrorphan (DOR) from dextromethorphan (DEX) is widely used as a marker to assess the activity of this enzyme both in vitro and in vivo." ], "offsets": [ [ 162, 350 ] ] }, { "id": "DS.d306.s2", "type": "", "text": [ "The sequential metabolism of DOR during in vitro studies, particularly using recombinant systems (rCYPs) expressing human CYP2D6, is assumed to be negligible." ], "offsets": [ [ 351, 509 ] ] }, { "id": "DS.d306.s3", "type": "", "text": [ "The extent of metabolism was investigated for a range of DEX and DOR concentrations in microsomal preparations from three different rCYPs expressing human CYP2D6 (yeast, Supersomes and Bactosomes) containing 10 pmol of the enzyme." ], "offsets": [ [ 510, 740 ] ] }, { "id": "DS.d306.s4", "type": "", "text": [ "Two novel CYP2D6 related metabolites were identified in Bactosomes, and assigned as single hydroxylations in the phenyl rings of DOR and HYM using ion-trap mass spectrometry." ], "offsets": [ [ 741, 915 ] ] } ]
[ { "id": "DS.d306.s0.e0", "type": "compound", "text": [ "dextrorphan" ], "offsets": [ [ 14, 25 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "3918" }, { "db_name": "PubChem", "db_id": "5360697" } ] }, { "id": "DS.d306.s0.e1", "type": "protein", "text": [ "CYP2D6" ], "offsets": [ [ 29, 35 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P10635" }, { "db_name": "UniProt", "db_id": "Q2XNC8" }, { "db_name": "UniProt", "db_id": "Q2XNC9" } ] }, { "id": "DS.d306.s0.e2", "type": "compound", "text": [ "dextromethorphan" ], "offsets": [ [ 133, 149 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "3008" }, { "db_name": "PubChem", "db_id": "5360696" }, { "db_name": "PubChem", "db_id": "5362449" }, { "db_name": "PubChem", "db_id": "12305042" } ] }, { "id": "DS.d306.s1.e0", "type": "protein", "text": [ "Cytochrome P450 2D6" ], "offsets": [ [ 162, 181 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P10635" }, { "db_name": "UniProt", "db_id": "Q2XNC8" }, { "db_name": "UniProt", "db_id": "Q2XNC9" } ] }, { "id": "DS.d306.s1.e1", "type": "protein", "text": [ "CYP2D6" ], "offsets": [ [ 183, 189 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P10635" }, { "db_name": "UniProt", "db_id": "Q2XNC8" }, { "db_name": "UniProt", "db_id": "Q2XNC9" } ] }, { "id": "DS.d306.s1.e2", "type": "compound", "text": [ "dextrorphan" ], "offsets": [ [ 213, 224 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "3918" }, { "db_name": "PubChem", "db_id": "5360697" } ] }, { "id": "DS.d306.s1.e3", "type": "compound", "text": [ "DOR" ], "offsets": [ [ 226, 229 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "439216" } ] }, { "id": "DS.d306.s1.e4", "type": "compound", "text": [ "dextromethorphan" ], "offsets": [ [ 236, 252 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "3008" }, { "db_name": "PubChem", "db_id": "5360696" }, { "db_name": "PubChem", "db_id": "5362449" }, { "db_name": "PubChem", "db_id": "12305042" } ] }, { "id": "DS.d306.s2.e0", "type": "compound", "text": [ "DOR" ], "offsets": [ [ 380, 383 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "439216" } ] }, { "id": "DS.d306.s2.e1", "type": "protein", "text": [ "CYP2D6" ], "offsets": [ [ 473, 479 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P10635" }, { "db_name": "UniProt", "db_id": "Q2XNC8" }, { "db_name": "UniProt", "db_id": "Q2XNC9" } ] }, { "id": "DS.d306.s3.e0", "type": "compound", "text": [ "DOR" ], "offsets": [ [ 575, 578 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "439216" } ] }, { "id": "DS.d306.s3.e1", "type": "protein", "text": [ "CYP2D6" ], "offsets": [ [ 665, 671 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P10635" }, { "db_name": "UniProt", "db_id": "Q2XNC8" }, { "db_name": "UniProt", "db_id": "Q2XNC9" } ] }, { "id": "DS.d306.s4.e0", "type": "protein", "text": [ "CYP2D6" ], "offsets": [ [ 751, 757 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P10635" }, { "db_name": "UniProt", "db_id": "Q2XNC8" }, { "db_name": "UniProt", "db_id": "Q2XNC9" } ] }, { "id": "DS.d306.s4.e1", "type": "compound", "text": [ "DOR" ], "offsets": [ [ 870, 873 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "439216" } ] }, { "id": "DS.d306.s4.e2", "type": "compound", "text": [ "HYM" ], "offsets": [ [ 878, 881 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "11840954" } ] } ]
[]
[]
[ { "id": "DS.d306.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d306.s0.e0", "arg2_id": "DS.d306.s0.e1", "normalized": [] }, { "id": "DS.d306.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d306.s1.e4", "arg2_id": "DS.d306.s1.e0", "normalized": [] }, { "id": "DS.d306.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d306.s1.e2", "arg2_id": "DS.d306.s1.e0", "normalized": [] }, { "id": "DS.d306.s1.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d306.s1.e2", "arg2_id": "DS.d306.s1.e1", "normalized": [] }, { "id": "DS.d306.s1.i3", "type": "compound-protein-interaction", "arg1_id": "DS.d306.s1.e4", "arg2_id": "DS.d306.s1.e1", "normalized": [] }, { "id": "DS.d306.s1.i4", "type": "compound-protein-interaction", "arg1_id": "DS.d306.s1.e3", "arg2_id": "DS.d306.s1.e0", "normalized": [] }, { "id": "DS.d306.s1.i5", "type": "compound-protein-interaction", "arg1_id": "DS.d306.s1.e3", "arg2_id": "DS.d306.s1.e1", "normalized": [] }, { "id": "DS.d306.s4.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d306.s4.e1", "arg2_id": "DS.d306.s4.e0", "normalized": [] }, { "id": "DS.d306.s4.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d306.s4.e2", "arg2_id": "DS.d306.s4.e0", "normalized": [] } ]
DS.d307
18543330
[ { "id": "DS.d307.s0", "type": "", "text": [ "The metal-coordinating residues in the active site of ILL2 include a conserved cysteine that clearly distinguishes this protein from previously structurally characterized members of the M20 peptidase family." ], "offsets": [ [ 0, 207 ] ] }, { "id": "DS.d307.s1", "type": "", "text": [ "Finally, the active site of ILL2 harbors an absolutely conserved glutamate (Glu172), which is well positioned to act as a general acid-base residue." ], "offsets": [ [ 208, 356 ] ] } ]
[ { "id": "DS.d307.s0.e0", "type": "protein", "text": [ "ILL2" ], "offsets": [ [ 54, 58 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P54970" } ] }, { "id": "DS.d307.s0.e1", "type": "compound", "text": [ "cysteine" ], "offsets": [ [ 79, 87 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "594" }, { "db_name": "PubChem", "db_id": "5862" }, { "db_name": "PubChem", "db_id": "5360637" } ] }, { "id": "DS.d307.s1.e0", "type": "protein", "text": [ "ILL2" ], "offsets": [ [ 236, 240 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P54970" } ] }, { "id": "DS.d307.s1.e1", "type": "compound", "text": [ "glutamate" ], "offsets": [ [ 273, 282 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "611" }, { "db_name": "PubChem", "db_id": "23327" }, { "db_name": "PubChem", "db_id": "33032" } ] } ]
[]
[]
[ { "id": "DS.d307.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d307.s0.e1", "arg2_id": "DS.d307.s0.e0", "normalized": [] }, { "id": "DS.d307.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d307.s1.e1", "arg2_id": "DS.d307.s1.e0", "normalized": [] } ]
DS.d308
18544044
[ { "id": "DS.d308.s0", "type": "", "text": [ "In this study, we tested the hypothesis that the Angiopoietin 1 (Ang1)/Tie2 pathway mediates simvastatin-induced vascular integrity and migration of neuroblasts after stroke." ], "offsets": [ [ 0, 174 ] ] }, { "id": "DS.d308.s1", "type": "", "text": [ "Simvastatin treatment significantly decreased blood-brain barrier (BBB) leakage and concomitantly, increased Ang1, Tie2 and Occludin expression in the ischaemic border (IBZ) compared to the MCAo control group." ], "offsets": [ [ 175, 384 ] ] }, { "id": "DS.d308.s2", "type": "", "text": [ "Simvastatin also significantly increased doublecortin (DCX, a marker of migrating neuroblasts) expression in the IBZ compared to control MCAo rats." ], "offsets": [ [ 385, 532 ] ] }, { "id": "DS.d308.s3", "type": "", "text": [ "The data show that simvastatin treatment of RBMEC increased Ang1 and Tie2 gene and protein expression and promoted phosphorylated-Tie2 activity." ], "offsets": [ [ 533, 677 ] ] }, { "id": "DS.d308.s4", "type": "", "text": [ "Simvastatin treatment of stroke increases Ang1/Tie2 expression and thereby reduces BBB leakage and promotes vascular stabilization." ], "offsets": [ [ 678, 809 ] ] }, { "id": "DS.d308.s5", "type": "", "text": [ "Ang1/Tie2 expression induced by simvastatin treatment promotes neuroblast micro-vascular coupling after stroke." ], "offsets": [ [ 810, 921 ] ] } ]
[ { "id": "DS.d308.s0.e0", "type": "protein", "text": [ "Ang1" ], "offsets": [ [ 65, 69 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P21570" } ] }, { "id": "DS.d308.s0.e1", "type": "protein", "text": [ "Tie2" ], "offsets": [ [ 71, 75 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O73791" }, { "db_name": "UniProt", "db_id": "Q02858" } ] }, { "id": "DS.d308.s0.e2", "type": "compound", "text": [ "simvastatin" ], "offsets": [ [ 93, 104 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "54454" }, { "db_name": "PubChem", "db_id": "4677798" } ] }, { "id": "DS.d308.s1.e0", "type": "compound", "text": [ "Simvastatin" ], "offsets": [ [ 175, 186 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "54454" }, { "db_name": "PubChem", "db_id": "4677798" } ] }, { "id": "DS.d308.s1.e1", "type": "protein", "text": [ "Ang1" ], "offsets": [ [ 284, 288 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P21570" } ] }, { "id": "DS.d308.s1.e2", "type": "protein", "text": [ "Tie2" ], "offsets": [ [ 290, 294 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O73791" }, { "db_name": "UniProt", "db_id": "Q02858" } ] }, { "id": "DS.d308.s1.e3", "type": "protein", "text": [ "Occludin" ], "offsets": [ [ 299, 307 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q16625" }, { "db_name": "UniProt", "db_id": "Q28269" }, { "db_name": "UniProt", "db_id": "Q28793" }, { "db_name": "UniProt", "db_id": "Q5RFS5" }, { "db_name": "UniProt", "db_id": "Q61146" }, { "db_name": "UniProt", "db_id": "Q6P6T5" }, { "db_name": "UniProt", "db_id": "Q91049" }, { "db_name": "UniProt", "db_id": "Q9PUN1" } ] }, { "id": "DS.d308.s2.e0", "type": "compound", "text": [ "Simvastatin" ], "offsets": [ [ 385, 396 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "54454" }, { "db_name": "PubChem", "db_id": "4677798" } ] }, { "id": "DS.d308.s2.e1", "type": "protein", "text": [ "DCX" ], "offsets": [ [ 440, 443 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O43602" } ] }, { "id": "DS.d308.s3.e0", "type": "compound", "text": [ "simvastatin" ], "offsets": [ [ 552, 563 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "54454" }, { "db_name": "PubChem", "db_id": "4677798" } ] }, { "id": "DS.d308.s3.e1", "type": "protein", "text": [ "Ang1" ], "offsets": [ [ 593, 597 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P21570" } ] }, { "id": "DS.d308.s3.e2", "type": "protein", "text": [ "Tie2" ], "offsets": [ [ 602, 606 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O73791" }, { "db_name": "UniProt", "db_id": "Q02858" } ] }, { "id": "DS.d308.s3.e3", "type": "protein", "text": [ "Tie2" ], "offsets": [ [ 663, 667 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O73791" }, { "db_name": "UniProt", "db_id": "Q02858" } ] }, { "id": "DS.d308.s4.e0", "type": "compound", "text": [ "Simvastatin" ], "offsets": [ [ 678, 689 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "54454" }, { "db_name": "PubChem", "db_id": "4677798" } ] }, { "id": "DS.d308.s4.e1", "type": "protein", "text": [ "Ang1" ], "offsets": [ [ 720, 724 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P21570" } ] }, { "id": "DS.d308.s4.e2", "type": "protein", "text": [ "Tie2" ], "offsets": [ [ 725, 729 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O73791" }, { "db_name": "UniProt", "db_id": "Q02858" } ] }, { "id": "DS.d308.s5.e0", "type": "protein", "text": [ "Ang1" ], "offsets": [ [ 810, 814 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P21570" } ] }, { "id": "DS.d308.s5.e1", "type": "protein", "text": [ "Tie2" ], "offsets": [ [ 815, 819 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O73791" }, { "db_name": "UniProt", "db_id": "Q02858" } ] }, { "id": "DS.d308.s5.e2", "type": "compound", "text": [ "simvastatin" ], "offsets": [ [ 842, 853 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "54454" }, { "db_name": "PubChem", "db_id": "4677798" } ] } ]
[]
[]
[ { "id": "DS.d308.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d308.s1.e0", "arg2_id": "DS.d308.s1.e2", "normalized": [] }, { "id": "DS.d308.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d308.s1.e0", "arg2_id": "DS.d308.s1.e3", "normalized": [] }, { "id": "DS.d308.s1.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d308.s1.e0", "arg2_id": "DS.d308.s1.e1", "normalized": [] }, { "id": "DS.d308.s2.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d308.s2.e0", "arg2_id": "DS.d308.s2.e1", "normalized": [] }, { "id": "DS.d308.s3.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d308.s3.e0", "arg2_id": "DS.d308.s3.e2", "normalized": [] }, { "id": "DS.d308.s3.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d308.s3.e0", "arg2_id": "DS.d308.s3.e1", "normalized": [] }, { "id": "DS.d308.s4.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d308.s4.e0", "arg2_id": "DS.d308.s4.e2", "normalized": [] }, { "id": "DS.d308.s4.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d308.s4.e0", "arg2_id": "DS.d308.s4.e1", "normalized": [] }, { "id": "DS.d308.s5.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d308.s5.e2", "arg2_id": "DS.d308.s5.e1", "normalized": [] }, { "id": "DS.d308.s5.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d308.s5.e2", "arg2_id": "DS.d308.s5.e0", "normalized": [] } ]
DS.d309
18544047
[ { "id": "DS.d309.s0", "type": "", "text": [ "Suppressing the activity of ERRalpha in 3T3-L1 adipocytes reduces mitochondrial biogenesis but enhances glycolysis and basal glucose uptake." ], "offsets": [ [ 0, 140 ] ] }, { "id": "DS.d309.s2", "type": "", "text": [ "Therefore, ERRalpha stands at the crossroad of glucose and fatty acid utilization and acts as a homeostatic switch to regulate the flux of TCA cycle, mitochondrial membrane potential and glycolysis to maintain a steady level of ATP production, particularly, when mitochondrial biogenesis is reduced." ], "offsets": [ [ 141, 440 ] ] } ]
[ { "id": "DS.d309.s0.e0", "type": "protein", "text": [ "ERRalpha" ], "offsets": [ [ 28, 36 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O08580" }, { "db_name": "UniProt", "db_id": "P11474" } ] }, { "id": "DS.d309.s0.e1", "type": "compound", "text": [ "glucose" ], "offsets": [ [ 125, 132 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "206" }, { "db_name": "PubChem", "db_id": "5793" }, { "db_name": "PubChem", "db_id": "64689" }, { "db_name": "PubChem", "db_id": "79025" } ] }, { "id": "DS.d309.s2.e0", "type": "protein", "text": [ "ERRalpha" ], "offsets": [ [ 152, 160 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O08580" }, { "db_name": "UniProt", "db_id": "P11474" } ] }, { "id": "DS.d309.s2.e1", "type": "compound", "text": [ "glucose" ], "offsets": [ [ 188, 195 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "206" }, { "db_name": "PubChem", "db_id": "5793" }, { "db_name": "PubChem", "db_id": "64689" }, { "db_name": "PubChem", "db_id": "79025" } ] }, { "id": "DS.d309.s2.e2", "type": "compound", "text": [ "ATP" ], "offsets": [ [ 369, 372 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5957" } ] } ]
[]
[]
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DS.d310
18544592
[ { "id": "DS.d310.s0", "type": "", "text": [ "A significant decrease in mean total nitric oxide (NOx), nitrite, and nitrate levels was also found after G-CSF plus dexamethasone administration." ], "offsets": [ [ 0, 146 ] ] }, { "id": "DS.d310.s1", "type": "", "text": [ "Even if partially compensated with u-PA and protein C, increased FVIII and vWF activity, and decreased nitric oxide levels may still partially contribute to progress of thrombosis risk in rhG-CSF plus dexamethasone administered healthy granulocyte donors." ], "offsets": [ [ 147, 402 ] ] } ]
[ { "id": "DS.d310.s0.e0", "type": "compound", "text": [ "nitric oxide" ], "offsets": [ [ 37, 49 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "145068" } ] }, { "id": "DS.d310.s0.e1", "type": "compound", "text": [ "nitrate" ], "offsets": [ [ 70, 77 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "943" } ] }, { "id": "DS.d310.s0.e2", "type": "protein", "text": [ "G-CSF" ], "offsets": [ [ 106, 111 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O02708" }, { "db_name": "UniProt", "db_id": "O02837" }, { "db_name": "UniProt", "db_id": "P09919" }, { "db_name": "UniProt", "db_id": "P09920" }, { "db_name": "UniProt", "db_id": "P35833" }, { "db_name": "UniProt", "db_id": "P35834" }, { "db_name": "UniProt", "db_id": "Q28746" } ] }, { "id": "DS.d310.s0.e3", "type": "compound", "text": [ "dexamethasone" ], "offsets": [ [ 117, 130 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5743" } ] }, { "id": "DS.d310.s1.e0", "type": "protein", "text": [ "protein C" ], "offsets": [ [ 191, 200 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O55527" }, { "db_name": "UniProt", "db_id": "O55779" }, { "db_name": "UniProt", "db_id": "P02810" }, { "db_name": "UniProt", "db_id": "P03314" }, { "db_name": "UniProt", "db_id": "P03424" }, { "db_name": "UniProt", "db_id": "P04861" }, { "db_name": "UniProt", "db_id": "P04862" }, { "db_name": "UniProt", "db_id": "P06022" }, { "db_name": "UniProt", "db_id": "P06164" }, { "db_name": "UniProt", "db_id": "P06165" }, { "db_name": "UniProt", "db_id": "P06941" }, { "db_name": "UniProt", "db_id": "P07602" }, { "db_name": "UniProt", "db_id": "P08097" }, { "db_name": "UniProt", "db_id": "P10030" }, { "db_name": "UniProt", "db_id": "P14253" }, { "db_name": "UniProt", "db_id": "P14254" }, { "db_name": "UniProt", "db_id": "P14340" }, { "db_name": "UniProt", "db_id": "P26035" }, { "db_name": "UniProt", "db_id": "P26779" }, { "db_name": "UniProt", "db_id": "P27384" }, { "db_name": "UniProt", "db_id": "P28055" }, { "db_name": "UniProt", "db_id": "P29165" }, { "db_name": "UniProt", "db_id": "P32533" }, { "db_name": "UniProt", "db_id": "P32534" }, { "db_name": "UniProt", "db_id": "P32535" }, { "db_name": "UniProt", "db_id": "P35940" }, { "db_name": "UniProt", "db_id": "P35948" }, { "db_name": "UniProt", "db_id": "P35977" }, { "db_name": "UniProt", "db_id": "P69738" }, { "db_name": "UniProt", "db_id": "Q00794" }, { "db_name": "UniProt", "db_id": "Q03339" }, { "db_name": "UniProt", "db_id": "Q074N0" }, { "db_name": "UniProt", "db_id": "Q1X880" }, { "db_name": "UniProt", "db_id": "Q1X881" }, { "db_name": "UniProt", "db_id": "Q6DV88" }, { "db_name": "UniProt", "db_id": "Q6J3P1" }, { "db_name": "UniProt", "db_id": "Q89277" }, { "db_name": "UniProt", "db_id": "Q98803" }, { "db_name": "UniProt", "db_id": "Q997F1" }, { "db_name": "UniProt", "db_id": "Q9DUE0" }, { "db_name": "UniProt", "db_id": "Q9WS38" }, { "db_name": "UniProt", "db_id": "Q9YRV3" } ] }, { "id": "DS.d310.s1.e1", "type": "protein", "text": [ "vWF" ], "offsets": [ [ 222, 225 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P04275" }, { "db_name": "UniProt", "db_id": "P80012" }, { "db_name": "UniProt", "db_id": "Q28295" }, { "db_name": "UniProt", "db_id": "Q28833" }, { "db_name": "UniProt", "db_id": "Q8CIZ8" } ] }, { "id": "DS.d310.s1.e2", "type": "compound", "text": [ "nitric oxide" ], "offsets": [ [ 250, 262 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "145068" } ] }, { "id": "DS.d310.s1.e3", "type": "compound", "text": [ "dexamethasone" ], "offsets": [ [ 348, 361 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5743" } ] } ]
[]
[]
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DS.d312
18547170
[ { "id": "DS.d312.s0", "type": "", "text": [ "Amyloglucosidase from Rhizopus mould and beta-glucosidase from sweet almond were employed for the preparation of phenolic and vitamin glycosides of vanillin, N-vanillylnonanamide, DL-dopa, dopamine, curcumin, alpha-tocopherol (vitamin E), pyridoxine (vitamin B(6)), ergocalciferol (vitamin D (2)), thiamin (vitamin B(1)) and riboflavin (vitamin B(2))." ], "offsets": [ [ 0, 351 ] ] } ]
[ { "id": "DS.d312.s0.e0", "type": "protein", "text": [ "beta-glucosidase" ], "offsets": [ [ 41, 57 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P12614" }, { "db_name": "UniProt", "db_id": "P15885" }, { "db_name": "UniProt", "db_id": "P27034" }, { "db_name": "UniProt", "db_id": "P29091" }, { "db_name": "UniProt", "db_id": "P40740" }, { "db_name": "UniProt", "db_id": "Q03506" }, { "db_name": "UniProt", "db_id": "Q46684" } ] }, { "id": "DS.d312.s0.e1", "type": "compound", "text": [ "vanillin" ], "offsets": [ [ 148, 156 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1183" } ] }, { "id": "DS.d312.s0.e2", "type": "compound", "text": [ "N-vanillylnonanamide" ], "offsets": [ [ 158, 178 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2998" } ] }, { "id": "DS.d312.s0.e3", "type": "compound", "text": [ "DL-dopa" ], "offsets": [ [ 180, 187 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "836" } ] }, { "id": "DS.d312.s0.e4", "type": "compound", "text": [ "dopamine" ], "offsets": [ [ 189, 197 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "681" } ] }, { "id": "DS.d312.s0.e5", "type": "compound", "text": [ "curcumin" ], "offsets": [ [ 199, 207 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "969516" } ] }, { "id": "DS.d312.s0.e6", "type": "compound", "text": [ "alpha-tocopherol" ], "offsets": [ [ 209, 225 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2116" }, { "db_name": "PubChem", "db_id": "14985" } ] }, { "id": "DS.d312.s0.e7", "type": "compound", "text": [ "vitamin E" ], "offsets": [ [ 227, 236 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2116" }, { "db_name": "PubChem", "db_id": "14985" }, { "db_name": "PubChem", "db_id": "1548900" }, { "db_name": "PubChem", "db_id": "1742129" } ] }, { "id": "DS.d312.s0.e8", "type": "compound", "text": [ "pyridoxine" ], "offsets": [ [ 239, 249 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1054" } ] }, { "id": "DS.d312.s0.e9", "type": "compound", "text": [ "ergocalciferol (vitamin D" ], "offsets": [ [ 266, 291 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "3249" } ] }, { "id": "DS.d312.s0.e10", "type": "compound", "text": [ "thiamin" ], "offsets": [ [ 298, 305 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1130" } ] }, { "id": "DS.d312.s0.e11", "type": "compound", "text": [ "riboflavin" ], "offsets": [ [ 325, 335 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1072" }, { "db_name": "PubChem", "db_id": "6759" }, { "db_name": "PubChem", "db_id": "493570" } ] } ]
[]
[]
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DS.d313
18547363
[ { "id": "DS.d313.s0", "type": "", "text": [ "Ochratoxin A impairs Nrf2-dependent gene expression in porcine kidney tubulus cells." ], "offsets": [ [ 0, 84 ] ] }, { "id": "DS.d313.s1", "type": "", "text": [ "Therefore, in the present study, the effects of OTA on the nuclear translocation and transactivation of the transcription factor Nrf2 as well as mRNA levels of Nrf2 target genes including glutathione-S-transferase and gamma-glutamylcysteinyl synthetase have been studied in cultured porcine kidney tubulus cells (LLC-PK1)." ], "offsets": [ [ 85, 407 ] ] }, { "id": "DS.d313.s2", "type": "", "text": [ "Nrf2 was induced by sulforaphane, a well-known activator of this transcription factor." ], "offsets": [ [ 408, 494 ] ] }, { "id": "DS.d313.s3", "type": "", "text": [ "Ochratoxin A significantly decreased gamma-glutamylcysteinyl synthetase and glutathione-S-transferase mRNA levels in LLC-PK1 cells." ], "offsets": [ [ 495, 626 ] ] }, { "id": "DS.d313.s4", "type": "", "text": [ "Furthermore, OTA also lowered Nrf2 mRNA levels." ], "offsets": [ [ 627, 674 ] ] }, { "id": "DS.d313.s5", "type": "", "text": [ "Current data indicate that OTA nephrotoxicity may be, at least partly, mediated by an Nrf2-dependent signal transduction pathway." ], "offsets": [ [ 675, 804 ] ] } ]
[ { "id": "DS.d313.s0.e0", "type": "compound", "text": [ "Ochratoxin A" ], "offsets": [ [ 0, 12 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "442530" } ] }, { "id": "DS.d313.s0.e1", "type": "protein", "text": [ "Nrf2" ], "offsets": [ [ 21, 25 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O54968" }, { "db_name": "UniProt", "db_id": "Q60795" } ] }, { "id": "DS.d313.s1.e0", "type": "compound", "text": [ "OTA" ], "offsets": [ [ 133, 136 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "444766" } ] }, { "id": "DS.d313.s1.e1", "type": "protein", "text": [ "Nrf2" ], "offsets": [ [ 214, 218 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O54968" }, { "db_name": "UniProt", "db_id": "Q60795" } ] }, { "id": "DS.d313.s1.e2", "type": "protein", "text": [ "Nrf2" ], "offsets": [ [ 245, 249 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O54968" }, { "db_name": "UniProt", "db_id": "Q60795" } ] }, { "id": "DS.d313.s1.e3", "type": "protein", "text": [ "glutathione-S-transferase" ], "offsets": [ [ 273, 298 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O04437" }, { "db_name": "UniProt", "db_id": "O18598" }, { "db_name": "UniProt", "db_id": "P0A9D2" }, { "db_name": "UniProt", "db_id": "P0A9D3" }, { "db_name": "UniProt", "db_id": "P30116" }, { "db_name": "UniProt", "db_id": "P44521" }, { "db_name": "UniProt", "db_id": "P46088" }, { "db_name": "UniProt", "db_id": "P46419" }, { "db_name": "UniProt", "db_id": "P46423" }, { "db_name": "UniProt", "db_id": "P46426" }, { "db_name": "UniProt", "db_id": "P46428" }, { "db_name": "UniProt", "db_id": "P46437" }, { "db_name": "UniProt", "db_id": "P48438" }, { "db_name": "UniProt", "db_id": "P80894" }, { "db_name": "UniProt", "db_id": "P81065" }, { "db_name": "UniProt", "db_id": "P82996" }, { "db_name": "UniProt", "db_id": "P82997" }, { "db_name": "UniProt", "db_id": "P82998" }, { "db_name": "UniProt", "db_id": "P82999" }, { "db_name": "UniProt", "db_id": "P83000" }, { "db_name": "UniProt", "db_id": "P83001" }, { "db_name": "UniProt", "db_id": "P83246" }, { "db_name": "UniProt", "db_id": "Q04522" }, { "db_name": "UniProt", "db_id": "Q08392" }, { "db_name": "UniProt", "db_id": "Q08393" }, { "db_name": "UniProt", "db_id": "Q0ZS46" }, { "db_name": "UniProt", "db_id": "Q7REH6" }, { "db_name": "UniProt", "db_id": "Q8ILQ7" }, { "db_name": "UniProt", "db_id": "Q8MU52" }, { "db_name": "UniProt", "db_id": "Q96324" } ] }, { "id": "DS.d313.s2.e0", "type": "protein", "text": [ "Nrf2" ], "offsets": [ [ 408, 412 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O54968" }, { "db_name": "UniProt", "db_id": "Q60795" } ] }, { "id": "DS.d313.s2.e1", "type": "compound", "text": [ "sulforaphane" ], "offsets": [ [ 428, 440 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5350" } ] }, { "id": "DS.d313.s3.e0", "type": "compound", "text": [ "Ochratoxin A" ], "offsets": [ [ 495, 507 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "442530" } ] }, { "id": "DS.d313.s3.e1", "type": "protein", "text": [ "glutathione-S-transferase" ], "offsets": [ [ 571, 596 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O04437" }, { "db_name": "UniProt", "db_id": "O18598" }, { "db_name": "UniProt", "db_id": "P0A9D2" }, { "db_name": "UniProt", "db_id": "P0A9D3" }, { "db_name": "UniProt", "db_id": "P30116" }, { "db_name": "UniProt", "db_id": "P44521" }, { "db_name": "UniProt", "db_id": "P46088" }, { "db_name": "UniProt", "db_id": "P46419" }, { "db_name": "UniProt", "db_id": "P46423" }, { "db_name": "UniProt", "db_id": "P46426" }, { "db_name": "UniProt", "db_id": "P46428" }, { "db_name": "UniProt", "db_id": "P46437" }, { "db_name": "UniProt", "db_id": "P48438" }, { "db_name": "UniProt", "db_id": "P80894" }, { "db_name": "UniProt", "db_id": "P81065" }, { "db_name": "UniProt", "db_id": "P82996" }, { "db_name": "UniProt", "db_id": "P82997" }, { "db_name": "UniProt", "db_id": "P82998" }, { "db_name": "UniProt", "db_id": "P82999" }, { "db_name": "UniProt", "db_id": "P83000" }, { "db_name": "UniProt", "db_id": "P83001" }, { "db_name": "UniProt", "db_id": "P83246" }, { "db_name": "UniProt", "db_id": "Q04522" }, { "db_name": "UniProt", "db_id": "Q08392" }, { "db_name": "UniProt", "db_id": "Q08393" }, { "db_name": "UniProt", "db_id": "Q0ZS46" }, { "db_name": "UniProt", "db_id": "Q7REH6" }, { "db_name": "UniProt", "db_id": "Q8ILQ7" }, { "db_name": "UniProt", "db_id": "Q8MU52" }, { "db_name": "UniProt", "db_id": "Q96324" } ] }, { "id": "DS.d313.s4.e0", "type": "compound", "text": [ "OTA" ], "offsets": [ [ 640, 643 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "444766" } ] }, { "id": "DS.d313.s4.e1", "type": "protein", "text": [ "Nrf2" ], "offsets": [ [ 657, 661 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O54968" }, { "db_name": "UniProt", "db_id": "Q60795" } ] }, { "id": "DS.d313.s5.e0", "type": "compound", "text": [ "OTA" ], "offsets": [ [ 702, 705 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "444766" } ] }, { "id": "DS.d313.s5.e1", "type": "protein", "text": [ "Nrf2" ], "offsets": [ [ 761, 765 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O54968" }, { "db_name": "UniProt", "db_id": "Q60795" } ] } ]
[]
[]
[ { "id": "DS.d313.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d313.s0.e0", "arg2_id": "DS.d313.s0.e1", "normalized": [] }, { "id": "DS.d313.s2.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d313.s2.e1", "arg2_id": "DS.d313.s2.e0", "normalized": [] }, { "id": "DS.d313.s3.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d313.s3.e0", "arg2_id": "DS.d313.s3.e1", "normalized": [] }, { "id": "DS.d313.s4.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d313.s4.e0", "arg2_id": "DS.d313.s4.e1", "normalized": [] }, { "id": "DS.d313.s5.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d313.s5.e0", "arg2_id": "DS.d313.s5.e1", "normalized": [] } ]
DS.d314
18547754
[ { "id": "DS.d314.s0", "type": "", "text": [ "Parthenogenetic porcine blastocysts were generated by the following methods: (1) electroporation followed by blocking the activity of specific protein kinases with butyrolactone I ; (2) electroporation followed by inhibition of protein synthesis using cycloheximide ; and (3) electroporation only (control)." ], "offsets": [ [ 0, 307 ] ] } ]
[ { "id": "DS.d314.s0.e0", "type": "protein", "text": [ "protein kinases" ], "offsets": [ [ 143, 158 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P00513" }, { "db_name": "UniProt", "db_id": "P25848" } ] }, { "id": "DS.d314.s0.e1", "type": "compound", "text": [ "butyrolactone I" ], "offsets": [ [ 164, 179 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "123740" }, { "db_name": "PubChem", "db_id": "5235506" }, { "db_name": "PubChem", "db_id": "51340302" } ] }, { "id": "DS.d314.s0.e2", "type": "compound", "text": [ "cycloheximide" ], "offsets": [ [ 252, 265 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6197" } ] } ]
[]
[]
[ { "id": "DS.d314.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d314.s0.e1", "arg2_id": "DS.d314.s0.e0", "normalized": [] } ]
DS.d315
18547755
[ { "id": "DS.d315.s0", "type": "", "text": [ "The aim of the present study was to investigate differences in the expression of mRNAs for ERalpha, ERbeta and PR in the sow uterus at different stages of the estrous cycle as well as in inseminated sows at estrus and during early pregnancy by use of solution hybridization and in relation to plasma levels of estradiol and progesterone." ], "offsets": [ [ 0, 337 ] ] } ]
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[]
[]
[]
DS.d316
18547796
[ { "id": "DS.d316.s0", "type": "", "text": [ "Increased incorporation of dietary plant sterols and cholesterol correlates with decreased expression of hepatic and intestinal Abcg5 and Abcg8 in diabetic BB rats." ], "offsets": [ [ 0, 164 ] ] }, { "id": "DS.d316.s1", "type": "", "text": [ "This increase in cholesterol and plant sterols and stanols was associated with a marked decrease in hepatic and intestinal Abcg5 (ATP-binding cassette transporter G5) and Abcg8 (ATP-binding cassette transporter G8) expressions in diabetic rats, as well as decreased mRNA levels of several other genes involved in sterol regulation." ], "offsets": [ [ 165, 496 ] ] }, { "id": "DS.d316.s2", "type": "", "text": [ "Therefore, lower expression levels of Abcg5/Abcg8 in diabetic rats may account for the increased accumulation of plant sterols and cholesterol in these rats." ], "offsets": [ [ 497, 654 ] ] } ]
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[]
[]
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DS.d317
18547798
[ { "id": "DS.d317.s0", "type": "", "text": [ "Gallic acid, ferulic acid and p-coumaric acid at a dosage of 100 mg kg(-1) body weight significantly increased the activities of cardiac superoxide dismutase, glutathione peroxidase (GPx) and catalase (CAT.05)." ], "offsets": [ [ 0, 210 ] ] } ]
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[]
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DS.d318
18547799
[ { "id": "DS.d318.s0", "type": "", "text": [ "These effects of genistein during the differentiation period were associated with down-regulation of ERalpha and ERbeta expression." ], "offsets": [ [ 0, 131 ] ] } ]
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[]
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DS.d319
18548182
[ { "id": "DS.d319.s0", "type": "", "text": [ "Activities of microbial extracellular enzymes involved in carbon, nitrogen, and phosphorus cycling declined appreciably with depth, the only exception being peroxidase." ], "offsets": [ [ 0, 168 ] ] } ]
[ { "id": "DS.d319.s0.e0", "type": "compound", "text": [ "nitrogen" ], "offsets": [ [ 66, 74 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "947" }, { "db_name": "PubChem", "db_id": "123329" } ] }, { "id": "DS.d319.s0.e1", "type": "compound", "text": [ "phosphorus" ], "offsets": [ [ 80, 90 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "24404" }, { "db_name": "PubChem", "db_id": "139579" } ] }, { "id": "DS.d319.s0.e2", "type": "protein", "text": [ "peroxidase" ], "offsets": [ [ 157, 167 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P15984" }, { "db_name": "UniProt", "db_id": "P16147" }, { "db_name": "UniProt", "db_id": "P84714" } ] } ]
[]
[]
[]
DS.d320
18548275
[ { "id": "DS.d320.s0", "type": "", "text": [ "Sulfonylurea (SU) treatment restores insulin secretion in patients with KCNJ11 mutations." ], "offsets": [ [ 0, 89 ] ] } ]
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[]
[]
[ { "id": "DS.d320.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d320.s0.e0", "arg2_id": "DS.d320.s0.e1", "normalized": [] } ]
DS.d321
18548615
[ { "id": "DS.d321.s0", "type": "", "text": [ "The purpose of this study was to investigate the effect of three zinc salts (i.e., zinc oxide, zinc carbonate, and zinc acetate) on insulin encapsulation efficiency (EE), stability, and in vitro release kinetics from poly(lactic-co-glycolic acid) (PLGA) microspheres." ], "offsets": [ [ 0, 267 ] ] } ]
[ { "id": "DS.d321.s0.e0", "type": "compound", "text": [ "zinc oxide" ], "offsets": [ [ 83, 93 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "14806" } ] }, { "id": "DS.d321.s0.e1", "type": "compound", "text": [ "zinc carbonate" ], "offsets": [ [ 95, 109 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "767" } ] }, { "id": "DS.d321.s0.e2", "type": "compound", "text": [ "zinc acetate" ], "offsets": [ [ 115, 127 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "176" } ] }, { "id": "DS.d321.s0.e3", "type": "protein", "text": [ "insulin" ], "offsets": [ [ 132, 139 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01314" }, { "db_name": "UniProt", "db_id": "P01316" }, { "db_name": "UniProt", "db_id": "P01319" }, { "db_name": "UniProt", "db_id": "P01320" }, { "db_name": "UniProt", "db_id": "P01324" }, { "db_name": "UniProt", "db_id": "P01328" }, { "db_name": "UniProt", "db_id": "P01330" }, { "db_name": "UniProt", "db_id": "P01331" }, { "db_name": "UniProt", "db_id": "P01334" }, { "db_name": "UniProt", "db_id": "P01336" }, { "db_name": "UniProt", "db_id": "P01340" }, { "db_name": "UniProt", "db_id": "P07453" }, { "db_name": "UniProt", "db_id": "P09476" }, { "db_name": "UniProt", "db_id": "P09477" }, { "db_name": "UniProt", "db_id": "P0C236" }, { "db_name": "UniProt", "db_id": "P12703" }, { "db_name": "UniProt", "db_id": "P12704" }, { "db_name": "UniProt", "db_id": "P12708" }, { "db_name": "UniProt", "db_id": "P13190" }, { "db_name": "UniProt", "db_id": "P18109" }, { "db_name": "UniProt", "db_id": "P29335" }, { "db_name": "UniProt", "db_id": "P42633" }, { "db_name": "UniProt", "db_id": "P67968" }, { "db_name": "UniProt", "db_id": "P67969" }, { "db_name": "UniProt", "db_id": "P67971" }, { "db_name": "UniProt", "db_id": "P67973" }, { "db_name": "UniProt", "db_id": "P67974" }, { "db_name": "UniProt", "db_id": "P68243" }, { "db_name": "UniProt", "db_id": "P68245" }, { "db_name": "UniProt", "db_id": "P68987" }, { "db_name": "UniProt", "db_id": "P68988" }, { "db_name": "UniProt", "db_id": "P68989" }, { "db_name": "UniProt", "db_id": "P68990" }, { "db_name": "UniProt", "db_id": "P68991" }, { "db_name": "UniProt", "db_id": "P68992" }, { "db_name": "UniProt", "db_id": "P69046" }, { "db_name": "UniProt", "db_id": "P69047" }, { "db_name": "UniProt", "db_id": "P69048" }, { "db_name": "UniProt", "db_id": "P81423" }, { "db_name": "UniProt", "db_id": "P81881" }, { "db_name": "UniProt", "db_id": "Q9TQY7" } ] }, { "id": "DS.d321.s0.e5", "type": "compound", "text": [ "PLGA" ], "offsets": [ [ 248, 252 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "36797" } ] } ]
[]
[]
[]
DS.d322
18550063
[ { "id": "DS.d322.s0", "type": "", "text": [ "Tumor necrosis factor-alpha inhibition protects against endotoxin-induced endothelial glycocalyx perturbation." ], "offsets": [ [ 0, 110 ] ] }, { "id": "DS.d322.s1", "type": "", "text": [ "In the present study, we investigated whether endotoxin-induced inflammatory reactions lead to a decrease of endothelial glycocalyx thickness in humans and whether tumor necrosis factor-alpha (TNFalpha) plays a role in this process." ], "offsets": [ [ 111, 343 ] ] } ]
[ { "id": "DS.d322.s0.e0", "type": "protein", "text": [ "Tumor necrosis factor" ], "offsets": [ [ 0, 21 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q8JFG3" } ] }, { "id": "DS.d322.s0.e1", "type": "compound", "text": [ "endotoxin" ], "offsets": [ [ 56, 65 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "44268108" } ] }, { "id": "DS.d322.s1.e0", "type": "compound", "text": [ "endotoxin" ], "offsets": [ [ 157, 166 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "44268108" } ] }, { "id": "DS.d322.s1.e1", "type": "protein", "text": [ "tumor necrosis factor" ], "offsets": [ [ 275, 296 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q8JFG3" } ] }, { "id": "DS.d322.s1.e2", "type": "protein", "text": [ "TNFalpha" ], "offsets": [ [ 304, 312 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O35734" }, { "db_name": "UniProt", "db_id": "O77510" }, { "db_name": "UniProt", "db_id": "O77764" }, { "db_name": "UniProt", "db_id": "P01375" }, { "db_name": "UniProt", "db_id": "P04924" }, { "db_name": "UniProt", "db_id": "P06804" }, { "db_name": "UniProt", "db_id": "P13296" }, { "db_name": "UniProt", "db_id": "P16599" }, { "db_name": "UniProt", "db_id": "P19101" }, { "db_name": "UniProt", "db_id": "P23383" }, { "db_name": "UniProt", "db_id": "P23563" }, { "db_name": "UniProt", "db_id": "P29553" }, { "db_name": "UniProt", "db_id": "P33620" }, { "db_name": "UniProt", "db_id": "P36939" }, { "db_name": "UniProt", "db_id": "P48094" }, { "db_name": "UniProt", "db_id": "P51435" }, { "db_name": "UniProt", "db_id": "P51742" }, { "db_name": "UniProt", "db_id": "P51743" }, { "db_name": "UniProt", "db_id": "P59684" }, { "db_name": "UniProt", "db_id": "P59693" }, { "db_name": "UniProt", "db_id": "P59694" }, { "db_name": "UniProt", "db_id": "P59695" }, { "db_name": "UniProt", "db_id": "P79337" }, { "db_name": "UniProt", "db_id": "P79374" }, { "db_name": "UniProt", "db_id": "Q06599" }, { "db_name": "UniProt", "db_id": "Q19LH4" }, { "db_name": "UniProt", "db_id": "Q1G1A2" }, { "db_name": "UniProt", "db_id": "Q1WM27" }, { "db_name": "UniProt", "db_id": "Q2MH05" }, { "db_name": "UniProt", "db_id": "Q539C2" }, { "db_name": "UniProt", "db_id": "Q75N23" }, { "db_name": "UniProt", "db_id": "Q8HZD9" }, { "db_name": "UniProt", "db_id": "Q8JFG3" }, { "db_name": "UniProt", "db_id": "Q8MKG8" }, { "db_name": "UniProt", "db_id": "Q8WNR1" }, { "db_name": "UniProt", "db_id": "Q9BEA1" } ] } ]
[]
[]
[ { "id": "DS.d322.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d322.s0.e1", "arg2_id": "DS.d322.s0.e0", "normalized": [] } ]
DS.d323
18550164
[ { "id": "DS.d323.s0", "type": "", "text": [ "The amino acid sequence deduced from the coding sequence encodes for a protein of 73 amino acids containing 21 cysteine residues." ], "offsets": [ [ 0, 129 ] ] } ]
[ { "id": "DS.d323.s0.e0", "type": "protein", "text": [ "a protein" ], "offsets": [ [ 69, 78 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P03161" }, { "db_name": "UniProt", "db_id": "P03610" }, { "db_name": "UniProt", "db_id": "P03631" }, { "db_name": "UniProt", "db_id": "P03632" }, { "db_name": "UniProt", "db_id": "P07394" }, { "db_name": "UniProt", "db_id": "P15966" }, { "db_name": "UniProt", "db_id": "P25243" }, { "db_name": "UniProt", "db_id": "P25244" }, { "db_name": "UniProt", "db_id": "P35823" }, { "db_name": "UniProt", "db_id": "P98005" } ] }, { "id": "DS.d323.s0.e1", "type": "compound", "text": [ "cysteine" ], "offsets": [ [ 111, 119 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "594" }, { "db_name": "PubChem", "db_id": "5862" }, { "db_name": "PubChem", "db_id": "5360637" } ] } ]
[]
[]
[ { "id": "DS.d323.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d323.s0.e1", "arg2_id": "DS.d323.s0.e0", "normalized": [] } ]
DS.d324
18550594
[ { "id": "DS.d324.s0", "type": "", "text": [ "Ultrastructural analysis in the macaque mediodorsal nucleus revealed that thalamic interneurons are a main postsynaptic target of DAT-ir axons ; this suggests that the marked expansion of the dopamine innervation in the primate in comparison to the rodent thalamus may be related to the presence of a sizable interneuron population in primates." ], "offsets": [ [ 0, 344 ] ] } ]
[ { "id": "DS.d324.s0.e0", "type": "protein", "text": [ "DAT" ], "offsets": [ [ 130, 133 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P13483" }, { "db_name": "UniProt", "db_id": "P23977" }, { "db_name": "UniProt", "db_id": "P27922" }, { "db_name": "UniProt", "db_id": "Q01959" }, { "db_name": "UniProt", "db_id": "Q03614" }, { "db_name": "UniProt", "db_id": "Q61327" }, { "db_name": "UniProt", "db_id": "Q9GJT6" } ] }, { "id": "DS.d324.s0.e1", "type": "compound", "text": [ "dopamine" ], "offsets": [ [ 192, 200 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "681" } ] } ]
[]
[]
[]
DS.d325
18550596
[ { "id": "DS.d325.s0", "type": "", "text": [ "Synapsin-dependent facilitation in MF synapses of WT mice was attenuated by blocking F-actin polymerization with cytochalasin B in hippocampal slices." ], "offsets": [ [ 0, 150 ] ] } ]
[ { "id": "DS.d325.s0.e0", "type": "protein", "text": [ "Synapsin" ], "offsets": [ [ 0, 8 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q24546" } ] }, { "id": "DS.d325.s0.e1", "type": "protein", "text": [ "actin" ], "offsets": [ [ 87, 92 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O00937" }, { "db_name": "UniProt", "db_id": "O13419" }, { "db_name": "UniProt", "db_id": "O16808" }, { "db_name": "UniProt", "db_id": "O17320" }, { "db_name": "UniProt", "db_id": "O65314" }, { "db_name": "UniProt", "db_id": "O65315" }, { "db_name": "UniProt", "db_id": "O65316" }, { "db_name": "UniProt", "db_id": "O74258" }, { "db_name": "UniProt", "db_id": "O81221" }, { "db_name": "UniProt", "db_id": "P02577" }, { "db_name": "UniProt", "db_id": "P10365" }, { "db_name": "UniProt", "db_id": "P10989" }, { "db_name": "UniProt", "db_id": "P11426" }, { "db_name": "UniProt", "db_id": "P13363" }, { "db_name": "UniProt", "db_id": "P14235" }, { "db_name": "UniProt", "db_id": "P17128" }, { "db_name": "UniProt", "db_id": "P20904" }, { "db_name": "UniProt", "db_id": "P24902" }, { "db_name": "UniProt", "db_id": "P26182" }, { "db_name": "UniProt", "db_id": "P26183" }, { "db_name": "UniProt", "db_id": "P30161" }, { "db_name": "UniProt", "db_id": "P45520" }, { "db_name": "UniProt", "db_id": "P45521" }, { "db_name": "UniProt", "db_id": "P48465" }, { "db_name": "UniProt", "db_id": "P50138" }, { "db_name": "UniProt", "db_id": "P51775" }, { "db_name": "UniProt", "db_id": "P53455" }, { "db_name": "UniProt", "db_id": "P53476" }, { "db_name": "UniProt", "db_id": "P53477" }, { "db_name": "UniProt", "db_id": "P53491" }, { "db_name": "UniProt", "db_id": "P53498" }, { "db_name": "UniProt", "db_id": "P53499" }, { "db_name": "UniProt", "db_id": "P53500" }, { "db_name": "UniProt", "db_id": "P53502" }, { "db_name": "UniProt", "db_id": "P53689" }, { "db_name": "UniProt", "db_id": "P60009" }, { "db_name": "UniProt", "db_id": "P60010" }, { "db_name": "UniProt", "db_id": "P60011" }, { "db_name": "UniProt", "db_id": "P68555" }, { "db_name": "UniProt", "db_id": "P78711" }, { "db_name": "UniProt", "db_id": "P80709" }, { "db_name": "UniProt", "db_id": "P81085" }, { "db_name": "UniProt", "db_id": "P90689" }, { "db_name": "UniProt", "db_id": "P91754" }, { "db_name": "UniProt", "db_id": "Q05214" }, { "db_name": "UniProt", "db_id": "Q11212" }, { "db_name": "UniProt", "db_id": "Q24733" }, { "db_name": "UniProt", "db_id": "Q2U7A3" }, { "db_name": "UniProt", "db_id": "Q39596" }, { "db_name": "UniProt", "db_id": "Q39758" }, { "db_name": "UniProt", "db_id": "Q6TCF2" }, { "db_name": "UniProt", "db_id": "Q75D00" }, { "db_name": "UniProt", "db_id": "Q8SWN8" }, { "db_name": "UniProt", "db_id": "Q8X119" }, { "db_name": "UniProt", "db_id": "Q92192" }, { "db_name": "UniProt", "db_id": "Q92193" }, { "db_name": "UniProt", "db_id": "Q99023" }, { "db_name": "UniProt", "db_id": "Q9P4D1" }, { "db_name": "UniProt", "db_id": "Q9UVF3" }, { "db_name": "UniProt", "db_id": "Q9UVX4" }, { "db_name": "UniProt", "db_id": "Q9UVZ8" } ] }, { "id": "DS.d325.s0.e2", "type": "compound", "text": [ "cytochalasin B" ], "offsets": [ [ 113, 127 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2919" }, { "db_name": "PubChem", "db_id": "5311281" }, { "db_name": "PubChem", "db_id": "5368686" }, { "db_name": "PubChem", "db_id": "5836499" }, { "db_name": "PubChem", "db_id": "6364615" }, { "db_name": "PubChem", "db_id": "6433621" } ] } ]
[]
[]
[ { "id": "DS.d325.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d325.s0.e2", "arg2_id": "DS.d325.s0.e0", "normalized": [] }, { "id": "DS.d325.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d325.s0.e2", "arg2_id": "DS.d325.s0.e1", "normalized": [] } ]
DS.d326
18551377
[ { "id": "DS.d326.s0", "type": "", "text": [ "Transformation was achieved using a vector that targets genes to the rrn16/rps12 intergenic region of the sugar beet plastome, employing the aadA gene as a selectable marker against spectinomycin and the gfp gene for visual screening of plastid transformants." ], "offsets": [ [ 0, 259 ] ] } ]
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[]
[]
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DS.d327
18552508
[ { "id": "DS.d327.s0", "type": "", "text": [ "Celecoxib inhibits serum amyloid a-induced matrix metalloproteinase-10 expression in human endothelial cells." ], "offsets": [ [ 0, 109 ] ] } ]
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[]
[]
[ { "id": "DS.d327.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d327.s0.e0", "arg2_id": "DS.d327.s0.e1", "normalized": [] } ]
DS.d328
18553142
[ { "id": "DS.d328.s0", "type": "", "text": [ "This article investigated the effect of sulfite on total antioxidant capacity (TAC), total oxidant status, lipid hydroperoxide (LOOH), and total free sulfydryl groups (-SH) levels in normal and SOX-deficient male albino rat plasma." ], "offsets": [ [ 0, 231 ] ] }, { "id": "DS.d328.s1", "type": "", "text": [ "SOX deficiency was established by feeding rats a low molybdenum diet and adding to their drinking water 200 ppm tungsten." ], "offsets": [ [ 232, 353 ] ] } ]
[ { "id": "DS.d328.s0.e0", "type": "compound", "text": [ "hydroperoxide" ], "offsets": [ [ 113, 126 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "784" } ] }, { "id": "DS.d328.s0.e1", "type": "protein", "text": [ "SOX" ], "offsets": [ [ 194, 197 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P79371" }, { "db_name": "UniProt", "db_id": "Q8JGM4" }, { "db_name": "UniProt", "db_id": "Q9S850" } ] }, { "id": "DS.d328.s1.e0", "type": "protein", "text": [ "SOX" ], "offsets": [ [ 232, 235 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P79371" }, { "db_name": "UniProt", "db_id": "Q8JGM4" }, { "db_name": "UniProt", "db_id": "Q9S850" } ] }, { "id": "DS.d328.s1.e1", "type": "compound", "text": [ "molybdenum" ], "offsets": [ [ 285, 295 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6422" }, { "db_name": "PubChem", "db_id": "23932" } ] }, { "id": "DS.d328.s1.e2", "type": "compound", "text": [ "tungsten" ], "offsets": [ [ 344, 352 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "23964" } ] } ]
[]
[]
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DS.d330
18554595
[ { "id": "DS.d330.s0", "type": "", "text": [ "To test the hypothesis that DHEAS production from DHEA occurs in hepatic cells and that this production is augmented by the presence of sex steroids or insulin." ], "offsets": [ [ 0, 160 ] ] } ]
[ { "id": "DS.d330.s0.e0", "type": "compound", "text": [ "DHEAS" ], "offsets": [ [ 28, 33 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "12594" } ] }, { "id": "DS.d330.s0.e1", "type": "compound", "text": [ "DHEA" ], "offsets": [ [ 28, 32 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5881" } ] }, { "id": "DS.d330.s0.e2", "type": "protein", "text": [ "insulin" ], "offsets": [ [ 152, 159 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01314" }, { "db_name": "UniProt", "db_id": "P01316" }, { "db_name": "UniProt", "db_id": "P01319" }, { "db_name": "UniProt", "db_id": "P01320" }, { "db_name": "UniProt", "db_id": "P01324" }, { "db_name": "UniProt", "db_id": "P01328" }, { "db_name": "UniProt", "db_id": "P01330" }, { "db_name": "UniProt", "db_id": "P01331" }, { "db_name": "UniProt", "db_id": "P01334" }, { "db_name": "UniProt", "db_id": "P01336" }, { "db_name": "UniProt", "db_id": "P01340" }, { "db_name": "UniProt", "db_id": "P07453" }, { "db_name": "UniProt", "db_id": "P09476" }, { "db_name": "UniProt", "db_id": "P09477" }, { "db_name": "UniProt", "db_id": "P0C236" }, { "db_name": "UniProt", "db_id": "P12703" }, { "db_name": "UniProt", "db_id": "P12704" }, { "db_name": "UniProt", "db_id": "P12708" }, { "db_name": "UniProt", "db_id": "P13190" }, { "db_name": "UniProt", "db_id": "P18109" }, { "db_name": "UniProt", "db_id": "P29335" }, { "db_name": "UniProt", "db_id": "P42633" }, { "db_name": "UniProt", "db_id": "P67968" }, { "db_name": "UniProt", "db_id": "P67969" }, { "db_name": "UniProt", "db_id": "P67971" }, { "db_name": "UniProt", "db_id": "P67973" }, { "db_name": "UniProt", "db_id": "P67974" }, { "db_name": "UniProt", "db_id": "P68243" }, { "db_name": "UniProt", "db_id": "P68245" }, { "db_name": "UniProt", "db_id": "P68987" }, { "db_name": "UniProt", "db_id": "P68988" }, { "db_name": "UniProt", "db_id": "P68989" }, { "db_name": "UniProt", "db_id": "P68990" }, { "db_name": "UniProt", "db_id": "P68991" }, { "db_name": "UniProt", "db_id": "P68992" }, { "db_name": "UniProt", "db_id": "P69046" }, { "db_name": "UniProt", "db_id": "P69047" }, { "db_name": "UniProt", "db_id": "P69048" }, { "db_name": "UniProt", "db_id": "P81423" }, { "db_name": "UniProt", "db_id": "P81881" }, { "db_name": "UniProt", "db_id": "Q9TQY7" } ] } ]
[]
[]
[]
DS.d331
18554598
[ { "id": "DS.d331.s0", "type": "", "text": [ "Changes in tumor necrosis factor (TNF) production by lipopolysaccharide-stimulated peripheral blood mononuclear cells significantly correlated with serum P levels in postmenopausal women subjected to estrogen/medroxyprogesterone therapy." ], "offsets": [ [ 0, 237 ] ] } ]
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[]
[]
[ { "id": "DS.d331.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d331.s0.e2", "arg2_id": "DS.d331.s0.e1", "normalized": [] }, { "id": "DS.d331.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d331.s0.e2", "arg2_id": "DS.d331.s0.e0", "normalized": [] } ]
DS.d332
18554690
[ { "id": "DS.d332.s0", "type": "", "text": [ "The differences in tissue distribution and protein levels of EcR-B1 during the programmed cell death indicate that the receptor plays a major role in the modulation and function of ecdysone activity in Bombyx anterior silk glands." ], "offsets": [ [ 0, 230 ] ] } ]
[ { "id": "DS.d332.s0.e0", "type": "protein", "text": [ "EcR" ], "offsets": [ [ 61, 64 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O18473" }, { "db_name": "UniProt", "db_id": "O18531" }, { "db_name": "UniProt", "db_id": "P34021" }, { "db_name": "UniProt", "db_id": "P49880" }, { "db_name": "UniProt", "db_id": "P49881" }, { "db_name": "UniProt", "db_id": "P49882" }, { "db_name": "UniProt", "db_id": "P49883" } ] }, { "id": "DS.d332.s0.e1", "type": "compound", "text": [ "ecdysone" ], "offsets": [ [ 181, 189 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "19212" }, { "db_name": "PubChem", "db_id": "4233007" }, { "db_name": "PubChem", "db_id": "5316996" } ] } ]
[]
[]
[ { "id": "DS.d332.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d332.s0.e1", "arg2_id": "DS.d332.s0.e0", "normalized": [] } ]
DS.d333
18555241
[ { "id": "DS.d333.s0", "type": "", "text": [ "Curcumin, a nutritional supplement with antineoplastic activity, enhances leiomyoma cell apoptosis and decreases fibronectin expression." ], "offsets": [ [ 0, 136 ] ] } ]
[ { "id": "DS.d333.s0.e0", "type": "compound", "text": [ "Curcumin" ], "offsets": [ [ 0, 8 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "969516" } ] }, { "id": "DS.d333.s0.e1", "type": "protein", "text": [ "fibronectin" ], "offsets": [ [ 113, 124 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P07589" }, { "db_name": "UniProt", "db_id": "P11722" }, { "db_name": "UniProt", "db_id": "Q28275" }, { "db_name": "UniProt", "db_id": "Q28377" }, { "db_name": "UniProt", "db_id": "Q28749" }, { "db_name": "UniProt", "db_id": "Q91289" }, { "db_name": "UniProt", "db_id": "Q91400" } ] } ]
[]
[]
[ { "id": "DS.d333.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d333.s0.e0", "arg2_id": "DS.d333.s0.e1", "normalized": [] } ]
DS.d334
18555557
[ { "id": "DS.d334.s0", "type": "", "text": [ "Methylthioadenosine phosphorylase (MTAP) is involved in the metabolism of purines and converts methylthioadenosine (MTA) to adenine." ], "offsets": [ [ 0, 132 ] ] }, { "id": "DS.d334.s1", "type": "", "text": [ "Methylation-specific primers were used to analyze methylation of the MTAP promoter, using DNA treated with sodium bisulfite." ], "offsets": [ [ 133, 257 ] ] } ]
[ { "id": "DS.d334.s0.e0", "type": "protein", "text": [ "MTAP" ], "offsets": [ [ 35, 39 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q13126" } ] }, { "id": "DS.d334.s0.e1", "type": "compound", "text": [ "adenine" ], "offsets": [ [ 124, 131 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "190" } ] }, { "id": "DS.d334.s1.e0", "type": "protein", "text": [ "MTAP" ], "offsets": [ [ 202, 206 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q13126" } ] }, { "id": "DS.d334.s1.e1", "type": "compound", "text": [ "sodium bisulfite" ], "offsets": [ [ 240, 256 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "23665763" } ] } ]
[]
[]
[ { "id": "DS.d334.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d334.s0.e1", "arg2_id": "DS.d334.s0.e0", "normalized": [] } ]
DS.d335
18555679
[ { "id": "DS.d335.s0", "type": "", "text": [ "Long-chain fatty alcohols also reduced tumor necrosis factor-alpha and prostaglandin E(2) production, although the potency of inhibition for the latter was lower." ], "offsets": [ [ 0, 162 ] ] } ]
[ { "id": "DS.d335.s0.e0", "type": "compound", "text": [ "fatty alcohols" ], "offsets": [ [ 11, 25 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "62238" } ] }, { "id": "DS.d335.s0.e1", "type": "protein", "text": [ "tumor necrosis factor" ], "offsets": [ [ 39, 60 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q8JFG3" } ] } ]
[]
[]
[ { "id": "DS.d335.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d335.s0.e0", "arg2_id": "DS.d335.s0.e1", "normalized": [] } ]
DS.d336
18556000
[ { "id": "DS.d336.s0", "type": "", "text": [ "Neopterin is released from human monocyte-derived macrophages upon stimulation with interferon-gamma and is a sensitive indicator for cellular immune activation." ], "offsets": [ [ 0, 161 ] ] } ]
[ { "id": "DS.d336.s0.e0", "type": "compound", "text": [ "Neopterin" ], "offsets": [ [ 0, 9 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "4455" } ] }, { "id": "DS.d336.s0.e1", "type": "protein", "text": [ "interferon-gamma" ], "offsets": [ [ 84, 100 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q9TTB0" } ] } ]
[]
[]
[ { "id": "DS.d336.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d336.s0.e0", "arg2_id": "DS.d336.s0.e1", "normalized": [] } ]
DS.d337
18556087
[ { "id": "DS.d337.s0", "type": "", "text": [ "Both activity and expression of sulfate transporters and APS reductase in plants are modulated by the sulfur status of the plant." ], "offsets": [ [ 0, 129 ] ] } ]
[ { "id": "DS.d337.s0.e0", "type": "protein", "text": [ "sulfate transporters" ], "offsets": [ [ 32, 52 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O70531" }, { "db_name": "UniProt", "db_id": "P50443" }, { "db_name": "UniProt", "db_id": "Q62273" } ] }, { "id": "DS.d337.s0.e2", "type": "compound", "text": [ "sulfur" ], "offsets": [ [ 102, 108 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "402" } ] } ]
[]
[]
[ { "id": "DS.d337.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d337.s0.e2", "arg2_id": "DS.d337.s0.e0", "normalized": [] } ]
DS.d338
18560889
[ { "id": "DS.d338.s0", "type": "", "text": [ "Complex I deficiency is a novel cause of secretory diarrhea and may act via disrupting the supply of adenosine triphosphate (ATP) needed for the maintenance of ion gradients across membranes." ], "offsets": [ [ 0, 191 ] ] } ]
[ { "id": "DS.d338.s0.e0", "type": "protein", "text": [ "Complex I" ], "offsets": [ [ 0, 9 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q07842" } ] }, { "id": "DS.d338.s0.e1", "type": "compound", "text": [ "adenosine triphosphate" ], "offsets": [ [ 101, 123 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5957" } ] }, { "id": "DS.d338.s0.e2", "type": "compound", "text": [ "ATP" ], "offsets": [ [ 125, 128 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5957" } ] } ]
[]
[]
[ { "id": "DS.d338.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d338.s0.e1", "arg2_id": "DS.d338.s0.e0", "normalized": [] }, { "id": "DS.d338.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d338.s0.e2", "arg2_id": "DS.d338.s0.e0", "normalized": [] } ]
DS.d339
18561093
[ { "id": "DS.d339.s0", "type": "", "text": [ "This prospective cross-sectional study was performed to investigate the influence of GH excess on leptin and ghrelin levels at baseline and after glucose load in a large group of acromegalic patients." ], "offsets": [ [ 0, 200 ] ] } ]
[ { "id": "DS.d339.s0.e0", "type": "protein", "text": [ "leptin" ], "offsets": [ [ 98, 104 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O02750" }, { "db_name": "UniProt", "db_id": "O93416" }, { "db_name": "UniProt", "db_id": "Q28603" }, { "db_name": "UniProt", "db_id": "Q95189" }, { "db_name": "UniProt", "db_id": "Q95234" } ] }, { "id": "DS.d339.s0.e1", "type": "protein", "text": [ "ghrelin" ], "offsets": [ [ 109, 116 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q6BEG6" }, { "db_name": "UniProt", "db_id": "Q6BEG7" }, { "db_name": "UniProt", "db_id": "Q9BDJ6" }, { "db_name": "UniProt", "db_id": "Q9BEF8" }, { "db_name": "UniProt", "db_id": "Q9EQX0" }, { "db_name": "UniProt", "db_id": "Q9GKY5" }, { "db_name": "UniProt", "db_id": "Q9QYH7" }, { "db_name": "UniProt", "db_id": "Q9UBU3" } ] }, { "id": "DS.d339.s0.e2", "type": "compound", "text": [ "glucose" ], "offsets": [ [ 146, 153 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "206" }, { "db_name": "PubChem", "db_id": "5793" }, { "db_name": "PubChem", "db_id": "64689" }, { "db_name": "PubChem", "db_id": "79025" } ] } ]
[]
[]
[]
DS.d340
18561170
[ { "id": "DS.d340.s0", "type": "", "text": [ "Trypsin digestion, fluorescence anisotropy, and NMR experiments presented here were designed to resolve the issue and show that in arm-dimerization domain, the arms are structured, although differently, in the presence and absence of arabinose." ], "offsets": [ [ 0, 244 ] ] } ]
[ { "id": "DS.d340.s0.e0", "type": "protein", "text": [ "Trypsin" ], "offsets": [ [ 0, 7 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P23916" }, { "db_name": "UniProt", "db_id": "P24664" }, { "db_name": "UniProt", "db_id": "P35050" }, { "db_name": "UniProt", "db_id": "P83348" }, { "db_name": "UniProt", "db_id": "Q59149" } ] }, { "id": "DS.d340.s0.e1", "type": "compound", "text": [ "arabinose" ], "offsets": [ [ 234, 243 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "66308" } ] } ]
[]
[]
[]
DS.d341
18561187
[ { "id": "DS.d341.s0", "type": "", "text": [ "DNA array studies have revealed that YhaK is strongly up-regulated by nitroso-glutathione (GSNO) and also displays a 12-fold increase in expression during biofilm growth of E. coli 83972 and VR50 in human urine." ], "offsets": [ [ 0, 211 ] ] }, { "id": "DS.d341.s1", "type": "", "text": [ "We found that the third cysteine in YhaK, Cys122, is oxidized to a sulfenic acid." ], "offsets": [ [ 212, 293 ] ] }, { "id": "DS.d341.s2", "type": "", "text": [ "E. coli thioredoxin reductase and NADPH produced ROS and caused oxidation and oligomerization of reduced YhaK." ], "offsets": [ [ 294, 404 ] ] } ]
[ { "id": "DS.d341.s0.e0", "type": "protein", "text": [ "YhaK" ], "offsets": [ [ 37, 41 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P42624" }, { "db_name": "UniProt", "db_id": "P58115" } ] }, { "id": "DS.d341.s0.e2", "type": "compound", "text": [ "GSNO" ], "offsets": [ [ 91, 95 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "3514" }, { "db_name": "PubChem", "db_id": "104858" }, { "db_name": "PubChem", "db_id": "10404739" } ] }, { "id": "DS.d341.s1.e0", "type": "compound", "text": [ "cysteine" ], "offsets": [ [ 236, 244 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "594" }, { "db_name": "PubChem", "db_id": "5862" }, { "db_name": "PubChem", "db_id": "5360637" } ] }, { "id": "DS.d341.s1.e1", "type": "protein", "text": [ "YhaK" ], "offsets": [ [ 248, 252 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P42624" }, { "db_name": "UniProt", "db_id": "P58115" } ] }, { "id": "DS.d341.s1.e2", "type": "compound", "text": [ "sulfenic acid" ], "offsets": [ [ 279, 292 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "447587" } ] }, { "id": "DS.d341.s2.e0", "type": "protein", "text": [ "thioredoxin reductase" ], "offsets": [ [ 302, 323 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O14313" }, { "db_name": "UniProt", "db_id": "O22711" }, { "db_name": "UniProt", "db_id": "O30973" }, { "db_name": "UniProt", "db_id": "O32823" }, { "db_name": "UniProt", "db_id": "O43099" }, { "db_name": "UniProt", "db_id": "O66790" }, { "db_name": "UniProt", "db_id": "O69777" }, { "db_name": "UniProt", "db_id": "O83790" }, { "db_name": "UniProt", "db_id": "O84101" }, { "db_name": "UniProt", "db_id": "P0A9P4" }, { "db_name": "UniProt", "db_id": "P0A9P5" }, { "db_name": "UniProt", "db_id": "P0AE52" }, { "db_name": "UniProt", "db_id": "P0AE53" }, { "db_name": "UniProt", "db_id": "P0AE54" }, { "db_name": "UniProt", "db_id": "P0AE55" }, { "db_name": "UniProt", "db_id": "P14292" }, { "db_name": "UniProt", "db_id": "P14293" }, { "db_name": "UniProt", "db_id": 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}, { "db_name": "UniProt", "db_id": "P56876" }, { "db_name": "UniProt", "db_id": "P57279" }, { "db_name": "UniProt", "db_id": "P57399" }, { "db_name": "UniProt", "db_id": "P61076" }, { "db_name": "UniProt", "db_id": "P65688" }, { "db_name": "UniProt", "db_id": "P65689" }, { "db_name": "UniProt", "db_id": "P66010" }, { "db_name": "UniProt", "db_id": "P66011" }, { "db_name": "UniProt", "db_id": "P73728" }, { "db_name": "UniProt", "db_id": "P75531" }, { "db_name": "UniProt", "db_id": "P80880" }, { "db_name": "UniProt", "db_id": "P80892" }, { "db_name": "UniProt", "db_id": "P81433" }, { "db_name": "UniProt", "db_id": "P94284" }, { "db_name": "UniProt", "db_id": "P99029" }, { "db_name": "UniProt", "db_id": "P99101" }, { "db_name": "UniProt", "db_id": "Q01116" }, { "db_name": "UniProt", "db_id": "Q05741" }, { "db_name": "UniProt", "db_id": "Q25861" }, { "db_name": "UniProt", "db_id": "Q53212" }, { "db_name": "UniProt", "db_id": "Q55624" }, { "db_name": "UniProt", "db_id": "Q5HHQ4" }, { "db_name": "UniProt", "db_id": "Q5HQW4" }, { "db_name": "UniProt", "db_id": "Q6BIS1" }, { "db_name": "UniProt", "db_id": "Q6C7L4" }, { "db_name": "UniProt", "db_id": "Q6FR39" }, { "db_name": "UniProt", "db_id": "Q6GB66" }, { "db_name": "UniProt", "db_id": "Q6GIM7" }, { "db_name": "UniProt", "db_id": "Q75CM8" }, { "db_name": "UniProt", "db_id": "Q7Z7S3" }, { "db_name": "UniProt", "db_id": "Q89AJ2" }, { "db_name": "UniProt", "db_id": "Q89AS1" }, { "db_name": "UniProt", "db_id": "Q8CPY8" }, { "db_name": "UniProt", "db_id": "Q8J0U0" }, { "db_name": "UniProt", "db_id": "Q8K9W0" }, { "db_name": "UniProt", "db_id": "Q8T6Z1" }, { "db_name": "UniProt", "db_id": "Q92375" }, { "db_name": "UniProt", "db_id": "Q928B5" }, { "db_name": "UniProt", "db_id": "Q92I02" }, { "db_name": "UniProt", "db_id": "Q98PK9" }, { "db_name": "UniProt", "db_id": "Q9BGI1" }, { "db_name": "UniProt", "db_id": "Q9GLW7" }, { "db_name": "UniProt", "db_id": "Q9GLW9" }, { "db_name": "UniProt", "db_id": "Q9KSS4" }, { "db_name": "UniProt", "db_id": "Q9M7T0" }, { "db_name": "UniProt", "db_id": "Q9PKT7" }, { "db_name": "UniProt", "db_id": "Q9PR71" }, { "db_name": "UniProt", "db_id": "Q9R063" }, { "db_name": "UniProt", "db_id": "Q9Z8M4" }, { "db_name": "UniProt", "db_id": "Q9ZD97" }, { "db_name": "UniProt", "db_id": "Q9ZHF0" }, { "db_name": "UniProt", "db_id": "Q9ZL18" }, { "db_name": "UniProt", "db_id": "Q9ZMU4" } ] }, { "id": "DS.d341.s2.e1", "type": "compound", "text": [ "NADPH" ], "offsets": [ [ 328, 333 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5884" } ] }, { "id": "DS.d341.s2.e2", "type": "protein", "text": [ "YhaK" ], "offsets": [ [ 399, 403 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P42624" }, { "db_name": "UniProt", "db_id": "P58115" } ] } ]
[]
[]
[ { "id": "DS.d341.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d341.s0.e2", "arg2_id": "DS.d341.s0.e0", "normalized": [] }, { "id": "DS.d341.s2.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d341.s2.e1", "arg2_id": "DS.d341.s2.e2", "normalized": [] } ]
DS.d342
18562331
[ { "id": "DS.d342.s0", "type": "", "text": [ "In this report, we investigated the possible role of LA and vmPFC NR2Bs in the consolidation of fear extinction using the NR2B-selective antagonist ifenprodil." ], "offsets": [ [ 0, 159 ] ] } ]
[ { "id": "DS.d342.s0.e0", "type": "protein", "text": [ "NR2Bs" ], "offsets": [ [ 66, 71 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q00960" }, { "db_name": "UniProt", "db_id": "Q01097" }, { "db_name": "UniProt", "db_id": "Q13224" } ] }, { "id": "DS.d342.s0.e1", "type": "protein", "text": [ "NR2B" ], "offsets": [ [ 66, 70 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q00960" }, { "db_name": "UniProt", "db_id": "Q01097" }, { "db_name": "UniProt", "db_id": "Q13224" } ] }, { "id": "DS.d342.s0.e2", "type": "compound", "text": [ "ifenprodil" ], "offsets": [ [ 148, 158 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "3689" }, { "db_name": "PubChem", "db_id": "6604117" }, { "db_name": "PubChem", "db_id": "11198145" }, { "db_name": "PubChem", "db_id": "11771731" } ] } ]
[]
[]
[]
DS.d343
18562423
[ { "id": "DS.d343.s0", "type": "", "text": [ "Patients under clozapine-risperidone therapy developed a rise of serum prolactin levels." ], "offsets": [ [ 0, 88 ] ] } ]
[ { "id": "DS.d343.s0.e0", "type": "compound", "text": [ "clozapine" ], "offsets": [ [ 15, 24 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2818" } ] }, { "id": "DS.d343.s0.e1", "type": "compound", "text": [ "risperidone" ], "offsets": [ [ 25, 36 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5073" } ] }, { "id": "DS.d343.s0.e2", "type": "protein", "text": [ "prolactin" ], "offsets": [ [ 71, 80 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P10765" }, { "db_name": "UniProt", "db_id": "P22393" }, { "db_name": "UniProt", "db_id": "P33089" }, { "db_name": "UniProt", "db_id": "P33090" }, { "db_name": "UniProt", "db_id": "P33091" }, { "db_name": "UniProt", "db_id": "P43001" } ] } ]
[]
[]
[ { "id": "DS.d343.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d343.s0.e1", "arg2_id": "DS.d343.s0.e2", "normalized": [] }, { "id": "DS.d343.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d343.s0.e0", "arg2_id": "DS.d343.s0.e2", "normalized": [] } ]
DS.d344
18562442
[ { "id": "DS.d344.s0", "type": "", "text": [ "In experiment 3, administration of E(2) or DPN to ovariectomised wildtype, but not betaERKO, mice decreased immobility compared with vehicle administration, these data suggest that ERbeta may be required for some of the anti-depressant-like effects of E(2)." ], "offsets": [ [ 0, 257 ] ] } ]
[ { "id": "DS.d344.s0.e0", "type": "compound", "text": [ "DPN" ], "offsets": [ [ 43, 46 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "926" }, { "db_name": "PubChem", "db_id": "5893" }, { "db_name": "PubChem", "db_id": "447862" } ] }, { "id": "DS.d344.s0.e1", "type": "protein", "text": [ "ERbeta" ], "offsets": [ [ 181, 187 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O08537" }, { "db_name": "UniProt", "db_id": "O13012" }, { "db_name": "UniProt", "db_id": "O93511" }, { "db_name": "UniProt", "db_id": "P57781" }, { "db_name": "UniProt", "db_id": "P57782" }, { "db_name": "UniProt", "db_id": "Q62986" }, { "db_name": "UniProt", "db_id": "Q92731" }, { "db_name": "UniProt", "db_id": "Q95171" }, { "db_name": "UniProt", "db_id": "Q9IAK1" }, { "db_name": "UniProt", "db_id": "Q9PTU5" }, { "db_name": "UniProt", "db_id": "Q9PVE2" }, { "db_name": "UniProt", "db_id": "Q9TTE5" }, { "db_name": "UniProt", "db_id": "Q9TU15" }, { "db_name": "UniProt", "db_id": "Q9W6M2" }, { "db_name": "UniProt", "db_id": "Q9XSB5" }, { "db_name": "UniProt", "db_id": "Q9XSW2" }, { "db_name": "UniProt", "db_id": "Q9YH32" } ] } ]
[]
[]
[]
DS.d345
18563306
[ { "id": "DS.d345.s0", "type": "", "text": [ "Simvastatin treatment significantly increased the number of peripheral blood CD34+ CD133+ cells, and serum concentration of vascular endothelial growth factor (VEGF) and AKT was markedly increased in vivo." ], "offsets": [ [ 0, 205 ] ] }, { "id": "DS.d345.s1", "type": "", "text": [ "In cultured EPC, simvastatin increased the concentrations of VEGF, AKT and eNOS." ], "offsets": [ [ 206, 286 ] ] }, { "id": "DS.d345.s2", "type": "", "text": [ "Western blots analysis showed that simvastatin increased the phosphorylation of eNOS and FKHRL1, which can be blocked by the PI3K/AKT pathway blocker LY294002." ], "offsets": [ [ 287, 446 ] ] }, { "id": "DS.d345.s3", "type": "", "text": [ "In in vitro study, simvastatin increases the phosphorylation of eNOS and of FKHRL1 through the PI3K/AKT signaling pathway." ], "offsets": [ [ 447, 569 ] ] } ]
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[]
[]
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DS.d346
18563517
[ { "id": "DS.d346.s0", "type": "", "text": [ "Only the intracellular IL-2 response in the lower tertile of IL-2 production was improved with glutamine indicating a small influence." ], "offsets": [ [ 0, 134 ] ] }, { "id": "DS.d346.s1", "type": "", "text": [ "The elevation of glutamine plasma levels by a perioperative intravenous infusion of L-alanyl-L-glutamine influenced the intracellular expression of IL-2 in the lower tertile only slightly." ], "offsets": [ [ 135, 323 ] ] } ]
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"UniProt", "db_id": "O62641" }, { "db_name": "UniProt", "db_id": "O77620" }, { "db_name": "UniProt", "db_id": "O97513" }, { "db_name": "UniProt", "db_id": "P04351" }, { "db_name": "UniProt", "db_id": "P05016" }, { "db_name": "UniProt", "db_id": "P17108" }, { "db_name": "UniProt", "db_id": "P19114" }, { "db_name": "UniProt", "db_id": "P26891" }, { "db_name": "UniProt", "db_id": "P36835" }, { "db_name": "UniProt", "db_id": "P37997" }, { "db_name": "UniProt", "db_id": "P46649" }, { "db_name": "UniProt", "db_id": "P51747" }, { "db_name": "UniProt", "db_id": "P60568" }, { "db_name": "UniProt", "db_id": "P60569" }, { "db_name": "UniProt", "db_id": "P68290" }, { "db_name": "UniProt", "db_id": "P68291" }, { "db_name": "UniProt", "db_id": "Q07885" }, { "db_name": "UniProt", "db_id": "Q08081" }, { "db_name": "UniProt", "db_id": "Q08867" }, { "db_name": "UniProt", "db_id": "Q1WM29" }, { "db_name": "UniProt", "db_id": "Q25BC3" }, { "db_name": "UniProt", "db_id": "Q29416" }, { "db_name": "UniProt", 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[ "glutamine" ], "offsets": [ [ 152, 161 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "738" }, { "db_name": "PubChem", "db_id": "5961" } ] }, { "id": "DS.d346.s1.e2", "type": "protein", "text": [ "IL-2" ], "offsets": [ [ 283, 287 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O62641" }, { "db_name": "UniProt", "db_id": "O77620" }, { "db_name": "UniProt", "db_id": "O97513" }, { "db_name": "UniProt", "db_id": "P04351" }, { "db_name": "UniProt", "db_id": "P05016" }, { "db_name": "UniProt", "db_id": "P17108" }, { "db_name": "UniProt", "db_id": "P19114" }, { "db_name": "UniProt", "db_id": "P26891" }, { "db_name": "UniProt", "db_id": "P36835" }, { "db_name": "UniProt", "db_id": "P37997" }, { "db_name": "UniProt", "db_id": "P46649" }, { "db_name": "UniProt", "db_id": "P51747" }, { "db_name": "UniProt", "db_id": "P60568" }, { "db_name": "UniProt", "db_id": "P60569" }, { "db_name": "UniProt", "db_id": "P68290" }, { "db_name": "UniProt", "db_id": "P68291" }, { "db_name": 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"db_id": "Q9XT84" } ] } ]
[]
[]
[ { "id": "DS.d346.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d346.s0.e2", "arg2_id": "DS.d346.s0.e0", "normalized": [] }, { "id": "DS.d346.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d346.s1.e0", "arg2_id": "DS.d346.s1.e2", "normalized": [] } ]
DS.d347
18563542
[ { "id": "DS.d347.s0", "type": "", "text": [ "Determination of bioactive matter by affinity adsorption solid substrate-room temperature phosphorimetry based on lectin labeled with self-ordered ring of eosin Y." ], "offsets": [ [ 0, 163 ] ] }, { "id": "DS.d347.s1", "type": "", "text": [ "Specific affinity adsorption (AA) reactions could be carried out between the products of concanavalin agglutinin (Con A), triticum vulgaris lectin (WGA) labeled with ESOR and alpha-fetoprotein variant (AFP-V), alkaline phosphatase (ALP), glucose (G), respectively." ], "offsets": [ [ 164, 428 ] ] } ]
[ { "id": "DS.d347.s0.e0", "type": "protein", "text": [ "lectin" ], "offsets": [ [ 114, 120 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P02871" }, { "db_name": "UniProt", "db_id": "P02873" }, { "db_name": "UniProt", "db_id": "P02874" }, { "db_name": "UniProt", "db_id": "P02875" }, { "db_name": "UniProt", "db_id": "P07386" }, { "db_name": "UniProt", "db_id": "P16108" }, { "db_name": "UniProt", "db_id": "P16349" }, { "db_name": "UniProt", "db_id": "P16351" }, { "db_name": "UniProt", "db_id": "P16352" }, { "db_name": "UniProt", "db_id": "P33888" }, { "db_name": "UniProt", "db_id": "P38662" }, { "db_name": "UniProt", "db_id": "P42088" }, { "db_name": "UniProt", "db_id": "P83410" }, { "db_name": "UniProt", "db_id": "P83511" }, { "db_name": "UniProt", "db_id": "P84987" }, { "db_name": "UniProt", "db_id": "Q41114" } ] }, { "id": "DS.d347.s0.e1", "type": "compound", "text": [ "eosin Y" ], "offsets": [ [ 155, 162 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "11049" }, { "db_name": "PubChem", "db_id": "27020" } ] }, { "id": "DS.d347.s1.e0", "type": "protein", "text": [ "agglutinin" ], "offsets": [ [ 266, 276 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P02872" }, { "db_name": "UniProt", "db_id": "P05046" }, { "db_name": "UniProt", "db_id": "P11218" }, { "db_name": "UniProt", "db_id": "P11219" }, { "db_name": "UniProt", "db_id": "P30617" }, { "db_name": "UniProt", "db_id": "P42088" }, { "db_name": "UniProt", "db_id": "P49329" }, { "db_name": "UniProt", "db_id": "P82859" }, { "db_name": "UniProt", "db_id": "P82953" } ] }, { "id": "DS.d347.s1.e1", "type": "protein", "text": [ "Con A" ], "offsets": [ [ 278, 283 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P02866" }, { "db_name": "UniProt", "db_id": "P14894" }, { "db_name": "UniProt", "db_id": "P81460" }, { "db_name": "UniProt", "db_id": "P81461" } ] }, { "id": "DS.d347.s1.e2", "type": "protein", "text": [ "lectin" ], "offsets": [ [ 304, 310 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P02871" }, { "db_name": "UniProt", "db_id": "P02873" }, { "db_name": "UniProt", "db_id": "P02874" }, { "db_name": "UniProt", "db_id": "P02875" }, { "db_name": "UniProt", "db_id": "P07386" }, { "db_name": "UniProt", "db_id": "P16108" }, { "db_name": "UniProt", "db_id": "P16349" }, { "db_name": "UniProt", "db_id": "P16351" }, { "db_name": "UniProt", "db_id": "P16352" }, { "db_name": "UniProt", "db_id": "P33888" }, { "db_name": "UniProt", "db_id": "P38662" }, { "db_name": "UniProt", "db_id": "P42088" }, { "db_name": "UniProt", "db_id": "P83410" }, { "db_name": "UniProt", "db_id": "P83511" }, { "db_name": "UniProt", "db_id": "P84987" }, { "db_name": "UniProt", "db_id": "Q41114" } ] }, { "id": "DS.d347.s1.e3", "type": "protein", "text": [ "AFP" ], "offsets": [ [ 366, 369 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O80994" }, { "db_name": "UniProt", "db_id": "O80995" }, { "db_name": "UniProt", "db_id": "P02771" }, { "db_name": "UniProt", "db_id": "P05140" }, { "db_name": "UniProt", "db_id": "P07835" }, { "db_name": "UniProt", "db_id": "P09031" }, { "db_name": "UniProt", "db_id": "P23699" }, { "db_name": "UniProt", "db_id": "P28050" }, { "db_name": "UniProt", "db_id": "P49066" }, { "db_name": "UniProt", "db_id": "P83128" }, { "db_name": "UniProt", "db_id": "P84407" }, { "db_name": "UniProt", "db_id": "Q01758" }, { "db_name": "UniProt", "db_id": "Q08617" }, { "db_name": "UniProt", "db_id": "Q12899" }, { "db_name": "UniProt", "db_id": "Q28789" }, { "db_name": "UniProt", "db_id": "Q3SZ57" }, { "db_name": "UniProt", "db_id": "Q8MJU5" } ] }, { "id": "DS.d347.s1.e4", "type": "protein", "text": [ "alkaline phosphatase" ], "offsets": [ [ 374, 394 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O60109" }, { "db_name": "UniProt", "db_id": "P81800" }, { "db_name": "UniProt", "db_id": "P83456" } ] }, { "id": "DS.d347.s1.e5", "type": "protein", "text": [ "ALP" ], "offsets": [ [ 396, 399 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P03973" }, { "db_name": "UniProt", "db_id": "P12547" }, { "db_name": "UniProt", "db_id": "P22298" }, { "db_name": "UniProt", "db_id": "P28296" }, { "db_name": "UniProt", "db_id": "P29118" }, { "db_name": "UniProt", "db_id": "P35211" }, { "db_name": "UniProt", "db_id": "P83610" }, { "db_name": "UniProt", "db_id": "P97430" }, { "db_name": "UniProt", "db_id": "Q03420" }, { "db_name": "UniProt", "db_id": "Q53GG5" }, { "db_name": "UniProt", "db_id": "Q9H0A0" }, { "db_name": "UniProt", "db_id": "Q9PU47" }, { "db_name": "UniProt", "db_id": "Q9Z1X0" } ] }, { "id": "DS.d347.s1.e6", "type": "compound", "text": [ "glucose" ], "offsets": [ [ 402, 409 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "206" }, { "db_name": "PubChem", "db_id": "5793" }, { "db_name": "PubChem", "db_id": "64689" }, { "db_name": "PubChem", "db_id": "79025" } ] } ]
[]
[]
[]
DS.d348
18563554
[ { "id": "DS.d348.s0", "type": "", "text": [ "In this paper we demonstrate that hedgehog signaling antagonists, including cyclopamine, and a second compound, CUR0199691, can inhibit growth of estrogen receptor (ER)-positive and ER-negative tumorigenic breast cancer cells at elevated doses." ], "offsets": [ [ 0, 244 ] ] } ]
[ { "id": "DS.d348.s0.e0", "type": "compound", "text": [ "cyclopamine" ], "offsets": [ [ 76, 87 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "442972" } ] }, { "id": "DS.d348.s0.e1", "type": "protein", "text": [ "estrogen receptor" ], "offsets": [ [ 146, 163 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O42132" }, { "db_name": "UniProt", "db_id": "P03372" }, { "db_name": "UniProt", "db_id": "P06211" }, { "db_name": "UniProt", "db_id": "P06212" }, { "db_name": "UniProt", "db_id": "P16058" }, { "db_name": "UniProt", "db_id": "P19785" }, { "db_name": "UniProt", "db_id": "P49884" }, { "db_name": "UniProt", "db_id": "P49885" }, { "db_name": "UniProt", "db_id": "P49886" }, { "db_name": "UniProt", "db_id": "P50240" }, { "db_name": "UniProt", "db_id": "P50241" }, { "db_name": "UniProt", "db_id": "P50242" }, { "db_name": "UniProt", "db_id": "P57717" }, { "db_name": "UniProt", "db_id": "P57753" }, { "db_name": "UniProt", "db_id": "P81559" }, { "db_name": "UniProt", "db_id": "Q29040" }, { "db_name": "UniProt", "db_id": "Q53AD2" }, { "db_name": "UniProt", "db_id": "Q91250" }, { "db_name": "UniProt", "db_id": "Q91424" }, { "db_name": "UniProt", "db_id": "Q9PVZ9" }, { "db_name": "UniProt", "db_id": "Q9QZJ5" }, { "db_name": "UniProt", "db_id": "Q9TV98" }, { "db_name": "UniProt", "db_id": "Q9YH33" }, { "db_name": "UniProt", "db_id": "Q9YHT3" }, { "db_name": "UniProt", "db_id": "Q9YHZ7" } ] } ]
[]
[]
[]
DS.d349
18563559
[ { "id": "DS.d349.s0", "type": "", "text": [ "The equality of K (D) of paroxetine binding to blood platelet membranes and to membranes from nerve endings appears to encourage the use of such membranes as a model for brain SERT." ], "offsets": [ [ 0, 181 ] ] } ]
[ { "id": "DS.d349.s0.e0", "type": "compound", "text": [ "paroxetine" ], "offsets": [ [ 25, 35 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "43815" } ] }, { "id": "DS.d349.s0.e1", "type": "protein", "text": [ "SERT" ], "offsets": [ [ 176, 180 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P31645" }, { "db_name": "UniProt", "db_id": "Q9XT49" } ] } ]
[]
[]
[]
DS.d350
18563560
[ { "id": "DS.d350.s0", "type": "", "text": [ "With supplementation of taurine in diet, lower expression of GFAP and VEGF while higher expression of GLAST, GS and GAD in retina of diabetic rats were determinated by RT-PCR 0.05)." ], "offsets": [ [ 0, 181 ] ] }, { "id": "DS.d350.s1", "type": "", "text": [ "GFAP, VEGF, GLAST, GS and GAD expressions in normal controls were not altered by taurine treatment." ], "offsets": [ [ 182, 281 ] ] } ]
[ { "id": "DS.d350.s0.e0", "type": "compound", "text": [ "taurine" ], "offsets": [ [ 24, 31 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1123" } ] }, { "id": "DS.d350.s0.e1", "type": "protein", "text": [ "GFAP" ], "offsets": [ [ 61, 65 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P03995" }, { "db_name": "UniProt", "db_id": "P14136" }, { "db_name": "UniProt", "db_id": "P47819" }, { "db_name": "UniProt", "db_id": "Q28115" } ] }, { "id": "DS.d350.s0.e2", "type": "protein", "text": [ "VEGF" ], "offsets": [ [ 70, 74 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P15691" }, { "db_name": "UniProt", "db_id": "P15692" }, { "db_name": "UniProt", "db_id": "P26617" }, { "db_name": "UniProt", "db_id": "P49151" }, { "db_name": "UniProt", "db_id": "P50412" }, { "db_name": "UniProt", "db_id": "P67964" }, { "db_name": "UniProt", "db_id": "P67965" }, { "db_name": "UniProt", "db_id": "Q99PS1" }, { "db_name": "UniProt", "db_id": "Q9GKR0" }, { "db_name": "UniProt", "db_id": "Q9MYV3" } ] }, { "id": "DS.d350.s0.e3", "type": "protein", "text": [ "GLAST" ], "offsets": [ [ 102, 107 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P24942" }, { "db_name": "UniProt", "db_id": "P56564" } ] }, { "id": "DS.d350.s0.e4", "type": "protein", "text": [ "GAD" ], "offsets": [ [ 116, 119 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P20228" }, { "db_name": "UniProt", "db_id": "P54767" }, { "db_name": "UniProt", "db_id": "Q04792" }, { "db_name": "UniProt", "db_id": "Q07346" }, { "db_name": "UniProt", "db_id": "Q42521" }, { "db_name": "UniProt", "db_id": "Q99259" }, { "db_name": "UniProt", "db_id": "Q9CG20" } ] }, { "id": "DS.d350.s1.e0", "type": "protein", "text": [ "GFAP" ], "offsets": [ [ 182, 186 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P03995" }, { "db_name": "UniProt", "db_id": "P14136" }, { "db_name": "UniProt", "db_id": "P47819" }, { "db_name": "UniProt", "db_id": "Q28115" } ] }, { "id": "DS.d350.s1.e1", "type": "protein", "text": [ "VEGF" ], "offsets": [ [ 188, 192 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P15691" }, { "db_name": "UniProt", "db_id": "P15692" }, { "db_name": "UniProt", "db_id": "P26617" }, { "db_name": "UniProt", "db_id": "P49151" }, { "db_name": "UniProt", "db_id": "P50412" }, { "db_name": "UniProt", "db_id": "P67964" }, { "db_name": "UniProt", "db_id": "P67965" }, { "db_name": "UniProt", "db_id": "Q99PS1" }, { "db_name": "UniProt", "db_id": "Q9GKR0" }, { "db_name": "UniProt", "db_id": "Q9MYV3" } ] }, { "id": "DS.d350.s1.e2", "type": "protein", "text": [ "GLAST" ], "offsets": [ [ 194, 199 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P24942" }, { "db_name": "UniProt", "db_id": "P56564" } ] }, { "id": "DS.d350.s1.e3", "type": "protein", "text": [ "GAD" ], "offsets": [ [ 208, 211 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P20228" }, { "db_name": "UniProt", "db_id": "P54767" }, { "db_name": "UniProt", "db_id": "Q04792" }, { "db_name": "UniProt", "db_id": "Q07346" }, { "db_name": "UniProt", "db_id": "Q42521" }, { "db_name": "UniProt", "db_id": "Q99259" }, { "db_name": "UniProt", "db_id": "Q9CG20" } ] }, { "id": "DS.d350.s1.e4", "type": "compound", "text": [ "taurine" ], "offsets": [ [ 263, 270 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1123" } ] } ]
[]
[]
[ { "id": "DS.d350.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d350.s0.e0", "arg2_id": "DS.d350.s0.e2", "normalized": [] }, { "id": "DS.d350.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d350.s0.e0", "arg2_id": "DS.d350.s0.e1", "normalized": [] }, { "id": "DS.d350.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d350.s0.e0", "arg2_id": "DS.d350.s0.e4", "normalized": [] }, { "id": "DS.d350.s0.i3", "type": "compound-protein-interaction", "arg1_id": "DS.d350.s0.e0", "arg2_id": "DS.d350.s0.e3", "normalized": [] } ]
DS.d351
18563561
[ { "id": "DS.d351.s0", "type": "", "text": [ "Malondialdehyde (MDA), glutathione (GSH), nitric oxide (NO) levels and myeloperoxidase activity (MPO) were examined in plasma, liver and brain tissues." ], "offsets": [ [ 0, 151 ] ] } ]
[ { "id": "DS.d351.s0.e0", "type": "compound", "text": [ "Malondialdehyde" ], "offsets": [ [ 0, 15 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "10964" } ] }, { "id": "DS.d351.s0.e1", "type": "compound", "text": [ "glutathione" ], "offsets": [ [ 23, 34 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "124886" } ] }, { "id": "DS.d351.s0.e2", "type": "compound", "text": [ "GSH" ], "offsets": [ [ 36, 39 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "124886" } ] }, { "id": "DS.d351.s0.e3", "type": "compound", "text": [ "nitric oxide" ], "offsets": [ [ 42, 54 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "145068" } ] }, { "id": "DS.d351.s0.e4", "type": "protein", "text": [ "MPO" ], "offsets": [ [ 97, 100 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P05164" }, { "db_name": "UniProt", "db_id": "P11247" } ] } ]
[]
[]
[]
DS.d352
18563616
[ { "id": "DS.d352.s0", "type": "", "text": [ "Glutathione peroxidase 1 (GPX1) is a ubiquitously expressed selenium-dependent enzyme that protects cells against oxidative damage by reducing hydrogen peroxide and a wide range of organic peroxides." ], "offsets": [ [ 0, 199 ] ] } ]
[ { "id": "DS.d352.s0.e0", "type": "protein", "text": [ "Glutathione peroxidase 1" ], "offsets": [ [ 0, 24 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O23970" }, { "db_name": "UniProt", "db_id": "P00435" }, { "db_name": "UniProt", "db_id": "P04041" }, { "db_name": "UniProt", "db_id": "P07203" }, { "db_name": "UniProt", "db_id": "P11352" }, { "db_name": "UniProt", "db_id": "P11909" }, { "db_name": "UniProt", "db_id": "P36014" }, { "db_name": "UniProt", "db_id": "Q4AEI1" }, { "db_name": "UniProt", "db_id": "Q4AEI2" }, { "db_name": "UniProt", "db_id": "Q4AEI3" }, { "db_name": "UniProt", "db_id": "Q865R2" }, { "db_name": "UniProt", "db_id": "Q8MJ14" } ] }, { "id": "DS.d352.s0.e1", "type": "protein", "text": [ "GPX1" ], "offsets": [ [ 26, 30 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O48646" }, { "db_name": "UniProt", "db_id": "P00435" }, { "db_name": "UniProt", "db_id": "P07203" }, { "db_name": "UniProt", "db_id": "P11909" }, { "db_name": "UniProt", "db_id": "P36014" }, { "db_name": "UniProt", "db_id": "P52032" }, { "db_name": "UniProt", "db_id": "Q00277" }, { "db_name": "UniProt", "db_id": "Q4AEI1" }, { "db_name": "UniProt", "db_id": "Q4AEI2" }, { "db_name": "UniProt", "db_id": "Q4AEI3" }, { "db_name": "UniProt", "db_id": "Q865R2" }, { "db_name": "UniProt", "db_id": "Q8MJ14" } ] }, { "id": "DS.d352.s0.e2", "type": "compound", "text": [ "hydrogen peroxide" ], "offsets": [ [ 143, 160 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "784" } ] } ]
[]
[]
[ { "id": "DS.d352.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d352.s0.e2", "arg2_id": "DS.d352.s0.e0", "normalized": [] }, { "id": "DS.d352.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d352.s0.e2", "arg2_id": "DS.d352.s0.e1", "normalized": [] } ]
DS.d353
18563708
[ { "id": "DS.d353.s0", "type": "", "text": [ "Nitric oxide (NO), which is produced by nitric oxide synthase (NOS), may play a role in the development of ASD." ], "offsets": [ [ 0, 111 ] ] } ]
[ { "id": "DS.d353.s0.e0", "type": "compound", "text": [ "Nitric oxide" ], "offsets": [ [ 0, 12 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "145068" } ] }, { "id": "DS.d353.s0.e1", "type": "protein", "text": [ "nitric oxide synthase" ], "offsets": [ [ 40, 61 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O61309" }, { "db_name": "UniProt", "db_id": "O61608" }, { "db_name": "UniProt", "db_id": "Q27571" }, { "db_name": "UniProt", "db_id": "Q9I9M2" } ] }, { "id": "DS.d353.s0.e2", "type": "protein", "text": [ "NOS" ], "offsets": [ [ 63, 66 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O54705" }, { "db_name": "UniProt", "db_id": "O61309" }, { "db_name": "UniProt", "db_id": "O61608" }, { "db_name": "UniProt", "db_id": "Q26240" }, { "db_name": "UniProt", "db_id": "Q28969" }, { "db_name": "UniProt", "db_id": "Q9I9M2" } ] } ]
[]
[]
[ { "id": "DS.d353.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d353.s0.e0", "arg2_id": "DS.d353.s0.e2", "normalized": [] }, { "id": "DS.d353.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d353.s0.e0", "arg2_id": "DS.d353.s0.e1", "normalized": [] } ]
DS.d354
18563803
[ { "id": "DS.d354.s0", "type": "", "text": [ "In conclusion, TAD-A has sufficient bonding strength and comparatively low toxicity in clinical use of 0.3 mmol or less of TAD and 0.8 mL of 44 w/w % HSA solution." ], "offsets": [ [ 0, 163 ] ] } ]
[ { "id": "DS.d354.s0.e0", "type": "compound", "text": [ "TAD" ], "offsets": [ [ 15, 18 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "124886" }, { "db_name": "PubChem", "db_id": "128225" } ] }, { "id": "DS.d354.s0.e1", "type": "compound", "text": [ "TAD" ], "offsets": [ [ 123, 126 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "124886" }, { "db_name": "PubChem", "db_id": "128225" } ] }, { "id": "DS.d354.s0.e2", "type": "protein", "text": [ "HSA" ], "offsets": [ [ 150, 153 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P24807" }, { "db_name": "UniProt", "db_id": "Q07490" } ] } ]
[]
[]
[]
DS.d355
18563826
[ { "id": "DS.d355.s0", "type": "", "text": [ "Long intercalated defects in canine ribs can be repaired successfully using porous beta-tricalcium phosphate (beta-TCP) cylinders, infused with a biodegradable polymer (poly D,L-lactic acid-polyethylene block copolymer) containing recombinant human bone morphogenetic protein-2 (rhBMP-2)." ], "offsets": [ [ 0, 288 ] ] } ]
[ { "id": "DS.d355.s0.e0", "type": "compound", "text": [ "beta-tricalcium phosphate" ], "offsets": [ [ 83, 108 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "24456" } ] }, { "id": "DS.d355.s0.e1", "type": "protein", "text": [ "morphogenetic protein" ], "offsets": [ [ 254, 275 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P07580" } ] } ]
[]
[]
[]
DS.d356
18564056
[ { "id": "DS.d356.s0", "type": "", "text": [ "In the present study we explored the possibility of using genetic engineering to increase the artemisinin content of A. annua by suppressing the expression of SQS (squalene synthase), a key enzyme of sterol pathway (a pathway competitive with that of artemisinin biosynthesis) by means of a hairpin-RNA-mediated RNAi (RNA interference) technique." ], "offsets": [ [ 0, 346 ] ] } ]
[ { "id": "DS.d356.s0.e0", "type": "compound", "text": [ "artemisinin" ], "offsets": [ [ 94, 105 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2240" }, { "db_name": "PubChem", "db_id": "68827" }, { "db_name": "PubChem", "db_id": "452191" }, { "db_name": "PubChem", "db_id": "641602" }, { "db_name": "PubChem", "db_id": "5458876" }, { "db_name": "PubChem", "db_id": "9838675" }, { "db_name": "PubChem", "db_id": "11836791" }, { "db_name": "PubChem", "db_id": "23757058" }, { "db_name": "PubChem", "db_id": "44266427" }, { "db_name": "PubChem", "db_id": "49796325" } ] }, { "id": "DS.d356.s0.e1", "type": "protein", "text": [ "SQS" ], "offsets": [ [ 159, 162 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O74165" }, { "db_name": "UniProt", "db_id": "P29704" }, { "db_name": "UniProt", "db_id": "P36596" }, { "db_name": "UniProt", "db_id": "P37268" }, { "db_name": "UniProt", "db_id": "P53798" }, { "db_name": "UniProt", "db_id": "P53799" }, { "db_name": "UniProt", "db_id": "P53800" }, { "db_name": "UniProt", "db_id": "P78589" }, { "db_name": "UniProt", "db_id": "Q02769" }, { "db_name": "UniProt", "db_id": "Q752X9" }, { "db_name": "UniProt", "db_id": "Q7S4Z6" }, { "db_name": "UniProt", "db_id": "Q92459" }, { "db_name": "UniProt", "db_id": "Q9HGZ6" }, { "db_name": "UniProt", "db_id": "Q9Y753" } ] }, { "id": "DS.d356.s0.e2", "type": "compound", "text": [ "artemisinin" ], "offsets": [ [ 251, 262 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2240" }, { "db_name": "PubChem", "db_id": "68827" }, { "db_name": "PubChem", "db_id": "452191" }, { "db_name": "PubChem", "db_id": "641602" }, { "db_name": "PubChem", "db_id": "5458876" }, { "db_name": "PubChem", "db_id": "9838675" }, { "db_name": "PubChem", "db_id": "11836791" }, { "db_name": "PubChem", "db_id": "23757058" }, { "db_name": "PubChem", "db_id": "44266427" }, { "db_name": "PubChem", "db_id": "49796325" } ] } ]
[]
[]
[]
DS.d357
18564176
[ { "id": "DS.d357.s0", "type": "", "text": [ "Glimepiride upregulates eNOS activity and inhibits cytokine-induced NF-kappaB activation through a phosphoinoside 3-kinase-Akt-dependent pathway." ], "offsets": [ [ 0, 145 ] ] } ]
[ { "id": "DS.d357.s0.e0", "type": "compound", "text": [ "Glimepiride" ], "offsets": [ [ 0, 11 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "3476" } ] }, { "id": "DS.d357.s0.e1", "type": "protein", "text": [ "eNOS" ], "offsets": [ [ 24, 28 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P29473" }, { "db_name": "UniProt", "db_id": "P29474" }, { "db_name": "UniProt", "db_id": "P70313" }, { "db_name": "UniProt", "db_id": "P79209" }, { "db_name": "UniProt", "db_id": "P97270" }, { "db_name": "UniProt", "db_id": "Q28969" }, { "db_name": "UniProt", "db_id": "Q62600" } ] } ]
[]
[]
[ { "id": "DS.d357.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d357.s0.e0", "arg2_id": "DS.d357.s0.e1", "normalized": [] } ]
DS.d358
18564211
[ { "id": "DS.d358.s0", "type": "", "text": [ "It has been reported that tamoxifen may affect hepatoma cell growth in vitro by suppressing transforming growth factor beta-1 (TGF-beta1) expression, suggesting that tamoxifen might also retard fibrogenesis." ], "offsets": [ [ 0, 207 ] ] }, { "id": "DS.d358.s1", "type": "", "text": [ "Thus, we examined whether tamoxifen might suppress TGF-beta1 expression and consequently inhibit the process of hepatic fibrosis in vivo." ], "offsets": [ [ 208, 345 ] ] } ]
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[]
[]
[ { "id": "DS.d358.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d358.s0.e0", "arg2_id": "DS.d358.s0.e1", "normalized": [] } ]
DS.d359
18564281
[ { "id": "DS.d359.s0", "type": "", "text": [ "We also explored the effect of substance P released by capsaicin because this neuropeptide is known to affect the microvasculature environment." ], "offsets": [ [ 0, 143 ] ] } ]
[ { "id": "DS.d359.s0.e0", "type": "protein", "text": [ "substance P" ], "offsets": [ [ 31, 42 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01289" }, { "db_name": "UniProt", "db_id": "P06767" }, { "db_name": "UniProt", "db_id": "P19850" }, { "db_name": "UniProt", "db_id": "P20366" }, { "db_name": "UniProt", "db_id": "P28498" }, { "db_name": "UniProt", "db_id": "P28499" }, { "db_name": "UniProt", "db_id": "P41333" }, { "db_name": "UniProt", "db_id": "P41539" }, { "db_name": "UniProt", "db_id": "P41540" }, { "db_name": "UniProt", "db_id": "P67932" }, { "db_name": "UniProt", "db_id": "P67933" }, { "db_name": "UniProt", "db_id": "Q60541" } ] }, { "id": "DS.d359.s0.e1", "type": "compound", "text": [ "capsaicin" ], "offsets": [ [ 55, 64 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1548943" } ] }, { "id": "DS.d359.s0.e2", "type": "protein", "text": [ "neuropeptide" ], "offsets": [ [ 78, 90 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P21259" } ] } ]
[]
[]
[]
DS.d360
18565553
[ { "id": "DS.d360.s0", "type": "", "text": [ "Leukotriene C4 release and gene expressions of IL-8 and MCP-1 in porcine alveolar epithelial type II cells." ], "offsets": [ [ 0, 107 ] ] }, { "id": "DS.d360.s1", "type": "", "text": [ "These findings suggest that AEC IIs play an important role in initial inflammatory reactions of the lung by releasing LTC4, and that they also modulate later inflammatory reactions, evidenced by consistent elevation of MCP-1 gene expression after and during exogenous challenge in pigs." ], "offsets": [ [ 108, 394 ] ] } ]
[ { "id": "DS.d360.s0.e0", "type": "compound", "text": [ "Leukotriene C4" ], "offsets": [ [ 0, 14 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "3907" }, { "db_name": "PubChem", "db_id": "5280493" }, { "db_name": "PubChem", "db_id": "5283121" }, { "db_name": "PubChem", "db_id": "5353716" } ] }, { "id": "DS.d360.s0.e1", "type": "protein", "text": [ "IL-8" ], "offsets": [ [ 47, 51 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O62812" }, { "db_name": "UniProt", "db_id": "P08317" }, { "db_name": "UniProt", "db_id": "P10145" }, { "db_name": "UniProt", "db_id": "P19874" }, { "db_name": "UniProt", "db_id": "P26894" }, { "db_name": "UniProt", "db_id": "P36925" }, { "db_name": "UniProt", "db_id": "P41324" }, { "db_name": "UniProt", "db_id": "P46653" }, { "db_name": "UniProt", "db_id": "P49113" }, { "db_name": "UniProt", "db_id": "P67813" }, { "db_name": "UniProt", "db_id": "P67814" }, { "db_name": "UniProt", "db_id": "P79255" }, { "db_name": "UniProt", "db_id": "Q102R3" }, { "db_name": "UniProt", "db_id": "Q7YRB5" }, { "db_name": "UniProt", "db_id": "Q9XSX5" } ] }, { "id": "DS.d360.s0.e2", "type": "protein", "text": [ "MCP-1" ], "offsets": [ [ 56, 61 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P10148" }, { "db_name": "UniProt", "db_id": "P13500" }, { "db_name": "UniProt", "db_id": "P14844" }, { "db_name": "UniProt", "db_id": "P28291" }, { "db_name": "UniProt", "db_id": "P28292" }, { "db_name": "UniProt", "db_id": "P42831" }, { "db_name": "UniProt", "db_id": "P52203" }, { "db_name": "UniProt", "db_id": "P61274" }, { "db_name": "UniProt", "db_id": "P61275" }, { "db_name": "UniProt", "db_id": "Q08782" }, { "db_name": "UniProt", "db_id": "Q9TTQ3" } ] }, { "id": "DS.d360.s1.e0", "type": "compound", "text": [ "LTC4" ], "offsets": [ [ 226, 230 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5280493" } ] }, { "id": "DS.d360.s1.e1", "type": "protein", "text": [ "MCP-1" ], "offsets": [ [ 327, 332 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P10148" }, { "db_name": "UniProt", "db_id": "P13500" }, { "db_name": "UniProt", "db_id": "P14844" }, { "db_name": "UniProt", "db_id": "P28291" }, { "db_name": "UniProt", "db_id": "P28292" }, { "db_name": "UniProt", "db_id": "P42831" }, { "db_name": "UniProt", "db_id": "P52203" }, { "db_name": "UniProt", "db_id": "P61274" }, { "db_name": "UniProt", "db_id": "P61275" }, { "db_name": "UniProt", "db_id": "Q08782" }, { "db_name": "UniProt", "db_id": "Q9TTQ3" } ] } ]
[]
[]
[]
DS.d361
18565581
[ { "id": "DS.d361.s0", "type": "", "text": [ "Whereas their toxicity is due to acetylcholinesterase inhibition, their secondary toxic effects have been related to free oxygen radicals." ], "offsets": [ [ 0, 138 ] ] }, { "id": "DS.d361.s1", "type": "", "text": [ "Diazinon diminished the plasma acetylcholinesterase activity on day 1 post-treatment, although testosterone levels remained unaffected." ], "offsets": [ [ 139, 274 ] ] }, { "id": "DS.d361.s2", "type": "", "text": [ "Melatonin pretreatment prevented every alteration induced by diazinon, except the diminution of acetylcholinesterase plasmatic activity." ], "offsets": [ [ 275, 411 ] ] } ]
[ { "id": "DS.d361.s0.e0", "type": "protein", "text": [ "acetylcholinesterase" ], "offsets": [ [ 33, 53 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q867X2" }, { "db_name": "UniProt", "db_id": "Q867X3" }, { "db_name": "UniProt", "db_id": "Q86GC9" }, { "db_name": "UniProt", "db_id": "Q92081" } ] }, { "id": "DS.d361.s0.e1", "type": "compound", "text": [ "oxygen" ], "offsets": [ [ 122, 128 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "977" } ] }, { "id": "DS.d361.s1.e0", "type": "compound", "text": [ "Diazinon" ], "offsets": [ [ 139, 147 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "3017" } ] }, { "id": "DS.d361.s1.e1", "type": "protein", "text": [ "acetylcholinesterase" ], "offsets": [ [ 170, 190 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q867X2" }, { "db_name": "UniProt", "db_id": "Q867X3" }, { "db_name": "UniProt", "db_id": "Q86GC9" }, { "db_name": "UniProt", "db_id": "Q92081" } ] }, { "id": "DS.d361.s1.e2", "type": "compound", "text": [ "testosterone" ], "offsets": [ [ 234, 246 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6013" } ] }, { "id": "DS.d361.s2.e0", "type": "compound", "text": [ "Melatonin" ], "offsets": [ [ 275, 284 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "896" } ] }, { "id": "DS.d361.s2.e1", "type": "compound", "text": [ "diazinon" ], "offsets": [ [ 336, 344 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "3017" } ] }, { "id": "DS.d361.s2.e2", "type": "protein", "text": [ "acetylcholinesterase" ], "offsets": [ [ 371, 391 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q867X2" }, { "db_name": "UniProt", "db_id": "Q867X3" }, { "db_name": "UniProt", "db_id": "Q86GC9" }, { "db_name": "UniProt", "db_id": "Q92081" } ] } ]
[]
[]
[ { "id": "DS.d361.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d361.s1.e0", "arg2_id": "DS.d361.s1.e1", "normalized": [] }, { "id": "DS.d361.s2.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d361.s2.e1", "arg2_id": "DS.d361.s2.e2", "normalized": [] } ]
DS.d362
18566887
[ { "id": "DS.d362.s0", "type": "", "text": [ "Sialic acid-specific O-acetyltransferases and O-acetylesterases are responsible for the metabolism of esterified sialic acids." ], "offsets": [ [ 0, 126 ] ] } ]
[ { "id": "DS.d362.s0.e0", "type": "protein", "text": [ "acetyltransferases" ], "offsets": [ [ 23, 41 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P16966" } ] }, { "id": "DS.d362.s0.e1", "type": "protein", "text": [ "acetylesterases" ], "offsets": [ [ 48, 63 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P23553" }, { "db_name": "UniProt", "db_id": "P23872" }, { "db_name": "UniProt", "db_id": "Q325C0" }, { "db_name": "UniProt", "db_id": "Q3Z4S3" }, { "db_name": "UniProt", "db_id": "Q57S73" }, { "db_name": "UniProt", "db_id": "Q5PFJ2" }, { "db_name": "UniProt", "db_id": "Q83M39" }, { "db_name": "UniProt", "db_id": "Q8FK82" }, { "db_name": "UniProt", "db_id": "Q8XD38" }, { "db_name": "UniProt", "db_id": "Q8Z8T1" }, { "db_name": "UniProt", "db_id": "Q8ZRA1" } ] }, { "id": "DS.d362.s0.e2", "type": "compound", "text": [ "sialic acids" ], "offsets": [ [ 113, 125 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "349960" } ] } ]
[]
[]
[ { "id": "DS.d362.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d362.s0.e2", "arg2_id": "DS.d362.s0.e0", "normalized": [] }, { "id": "DS.d362.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d362.s0.e2", "arg2_id": "DS.d362.s0.e1", "normalized": [] } ]
DS.d363
18567517
[ { "id": "DS.d363.s0", "type": "", "text": [ "Endomorphin-2 vector injection also reduced spontaneous pain-related behaviors in the delayed phase of the formalin test and in both CFA and formalin models suppressed spinal c-fos expression." ], "offsets": [ [ 0, 192 ] ] } ]
[ { "id": "DS.d363.s0.e0", "type": "compound", "text": [ "Endomorphin-2" ], "offsets": [ [ 0, 13 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5311081" } ] }, { "id": "DS.d363.s0.e1", "type": "protein", "text": [ "CFA" ], "offsets": [ [ 133, 136 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O04350" }, { "db_name": "UniProt", "db_id": "O75347" }, { "db_name": "UniProt", "db_id": "P48427" }, { "db_name": "UniProt", "db_id": "P48428" }, { "db_name": "UniProt", "db_id": "P48606" }, { "db_name": "UniProt", "db_id": "P80584" }, { "db_name": "UniProt", "db_id": "P80585" }, { "db_name": "UniProt", "db_id": "Q9Y703" } ] }, { "id": "DS.d363.s0.e2", "type": "protein", "text": [ "fos" ], "offsets": [ [ 177, 180 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01101" }, { "db_name": "UniProt", "db_id": "P12841" }, { "db_name": "UniProt", "db_id": "Q56415" } ] } ]
[]
[]
[ { "id": "DS.d363.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d363.s0.e0", "arg2_id": "DS.d363.s0.e2", "normalized": [] } ]
DS.d364
18568363
[ { "id": "DS.d364.s0", "type": "", "text": [ "Furthermore, 8-bromo-cGMP and peroxynitrite failed to reproduce the inhibitory effect of NO, indicating that NO acts directly on TonEBP rather than through classical NO signaling pathways." ], "offsets": [ [ 0, 188 ] ] }, { "id": "DS.d364.s1", "type": "", "text": [ "Nitric oxide decreases expression of osmoprotective genes via direct inhibition of TonEBP transcriptional activity." ], "offsets": [ [ 189, 304 ] ] }, { "id": "DS.d364.s2", "type": "", "text": [ "Because nitric oxide (NO) is abundantly produced in the renal medulla, the present studies addressed the effect of NO on expression of osmoprotective genes and TonEBP activation in MDCK cells." ], "offsets": [ [ 305, 497 ] ] } ]
[ { "id": "DS.d364.s0.e0", "type": "compound", "text": [ "8-bromo-cGMP" ], "offsets": [ [ 13, 25 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "104767" } ] }, { "id": "DS.d364.s0.e1", "type": "compound", "text": [ "peroxynitrite" ], "offsets": [ [ 30, 43 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "104806" } ] }, { "id": "DS.d364.s0.e2", "type": "protein", "text": [ "TonEBP" ], "offsets": [ [ 129, 135 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O94916" } ] }, { "id": "DS.d364.s1.e0", "type": "compound", "text": [ "Nitric oxide" ], "offsets": [ [ 189, 201 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "145068" } ] }, { "id": "DS.d364.s1.e1", "type": "protein", "text": [ "TonEBP" ], "offsets": [ [ 272, 278 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O94916" } ] }, { "id": "DS.d364.s2.e0", "type": "compound", "text": [ "nitric oxide" ], "offsets": [ [ 313, 325 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "145068" } ] }, { "id": "DS.d364.s2.e1", "type": "protein", "text": [ "TonEBP" ], "offsets": [ [ 465, 471 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O94916" } ] } ]
[]
[]
[ { "id": "DS.d364.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d364.s1.e0", "arg2_id": "DS.d364.s1.e1", "normalized": [] } ]
DS.d365
18568422
[ { "id": "DS.d365.s0", "type": "", "text": [ "Ran GTPase guanine nucleotide exchange factor RCC1 is phosphorylated on serine 11 by cdc2 kinase in vitro." ], "offsets": [ [ 0, 106 ] ] }, { "id": "DS.d365.s1", "type": "", "text": [ "An RCC1 mutant in which all N-terminal serine and threonine residues were substituted with glutamate residues to mimic phosphorylation at these residues showed decreased binding to the karyopherin, KPNA4, compared with wild type RCC1." ], "offsets": [ [ 107, 341 ] ] } ]
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[]
[]
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DS.d366
18568426
[ { "id": "DS.d366.s0", "type": "", "text": [ "ATP, acting on P2X (7) receptors, stimulates changes in intracellular calcium concentrations, maturation, and release of interleukin-1beta (IL-1beta), and following prolonged agonist exposure, cell death." ], "offsets": [ [ 0, 204 ] ] } ]
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DS.d368
18570315
[ { "id": "DS.d368.s0", "type": "", "text": [ "While the total insulin released during a 1 h glucose stimulation period was the same from islets in each sample, increasing hydrogel crosslinking density contributed to delays in insulin release from hydrogel samples within the 1 h stimulation period." ], "offsets": [ [ 0, 252 ] ] } ]
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[]
[]
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DS.d369
18570630
[ { "id": "DS.d369.s0", "type": "", "text": [ "Ischaemia and insulin, but not ischaemia and contraction, act synergistically in stimulating muscle glucose uptake in vivo in humans." ], "offsets": [ [ 0, 133 ] ] }, { "id": "DS.d369.s1", "type": "", "text": [ "In summary, ischaemia and insulin independently stimulate skeletal muscle glucose uptake in vivo in humans, whereas ischaemia and contraction do not." ], "offsets": [ [ 134, 283 ] ] } ]
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[]
[]
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DS.d370
18570631
[ { "id": "DS.d370.s0", "type": "", "text": [ "A comparison of the inhibitory effect of paraoxon on soluble and immobilized AChE showed that immobilization increased the linearity of the inhibition plot particularly in the range 0.1 nM-0.1 microM." ], "offsets": [ [ 0, 200 ] ] } ]
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[]
[]
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DS.d371
18570695
[ { "id": "DS.d371.s0", "type": "", "text": [ "7,12-Dimethyl-benz(a) anthracene (DMBA) can induce expressions of CYP1A1 and CYP1B1 which are known to be responsive to PAH." ], "offsets": [ [ 0, 124 ] ] } ]
[ { "id": "DS.d371.s0.e1", "type": "compound", "text": [ "DMBA" ], "offsets": [ [ 34, 38 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6001" } ] }, { "id": "DS.d371.s0.e2", "type": "protein", "text": [ "CYP1A1" ], "offsets": [ [ 66, 72 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O42231" }, { "db_name": "UniProt", "db_id": "O42430" }, { "db_name": "UniProt", "db_id": "O42457" }, { "db_name": "UniProt", "db_id": "P00185" }, { "db_name": "UniProt", "db_id": "P04798" }, { "db_name": "UniProt", "db_id": "P05176" }, { "db_name": "UniProt", "db_id": "P33616" }, { "db_name": "UniProt", "db_id": "P56590" }, { "db_name": "UniProt", "db_id": "P56591" }, { "db_name": "UniProt", "db_id": "P79716" }, { "db_name": "UniProt", "db_id": "P98181" }, { "db_name": "UniProt", "db_id": "Q00557" }, { "db_name": "UniProt", "db_id": "Q06367" }, { "db_name": "UniProt", "db_id": "Q3LFU0" }, { "db_name": "UniProt", "db_id": "Q5KQT7" }, { "db_name": "UniProt", "db_id": "Q6GUR1" }, { "db_name": "UniProt", "db_id": "Q6JZS3" }, { "db_name": "UniProt", "db_id": "Q92039" }, { "db_name": "UniProt", "db_id": "Q92095" }, { "db_name": "UniProt", "db_id": "Q92100" }, { "db_name": "UniProt", "db_id": "Q92109" }, { "db_name": "UniProt", "db_id": "Q92110" }, { "db_name": "UniProt", "db_id": "Q92116" }, { "db_name": "UniProt", "db_id": "Q92148" }, { "db_name": "UniProt", "db_id": "Q9W683" }, { "db_name": "UniProt", "db_id": "Q9YH64" } ] }, { "id": "DS.d371.s0.e3", "type": "protein", "text": [ "CYP1B1" ], "offsets": [ [ 77, 83 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q16678" } ] } ]
[]
[]
[ { "id": "DS.d371.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d371.s0.e1", "arg2_id": "DS.d371.s0.e3", "normalized": [] }, { "id": "DS.d371.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d371.s0.e1", "arg2_id": "DS.d371.s0.e2", "normalized": [] } ]
DS.d372
18571801
[ { "id": "DS.d372.s0", "type": "", "text": [ "Extracellular lipase LIP prepared in our lab from the yeast Yarrowia lipolytica was used for the resolution of racemic ibuprofen." ], "offsets": [ [ 0, 129 ] ] }, { "id": "DS.d372.s1", "type": "", "text": [ "The high purity (S)-ibuprofen (ee = 0.98) was obtained using lipase LIP to catalyze hydrolysis of (S)-ester in 0.1 M phosphate buffer (pH = 8)." ], "offsets": [ [ 130, 273 ] ] } ]
[ { "id": "DS.d372.s0.e0", "type": "protein", "text": [ "lipase" ], "offsets": [ [ 14, 20 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q7M4U7" } ] }, { "id": "DS.d372.s0.e1", "type": "protein", "text": [ "LIP" ], "offsets": [ [ 21, 24 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O59952" }, { "db_name": "UniProt", "db_id": "P21764" }, { "db_name": "UniProt", "db_id": "P49081" }, { "db_name": "UniProt", "db_id": "Q06383" }, { "db_name": "UniProt", "db_id": "Q96Q15" } ] }, { "id": "DS.d372.s0.e2", "type": "compound", "text": [ "ibuprofen" ], "offsets": [ [ 119, 128 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "3672" }, { "db_name": "PubChem", "db_id": "39912" } ] }, { "id": "DS.d372.s1.e0", "type": "compound", "text": [ "S)-ibuprofen" ], "offsets": [ [ 147, 159 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "39912" } ] }, { "id": "DS.d372.s1.e1", "type": "protein", "text": [ "lipase" ], "offsets": [ [ 191, 197 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q7M4U7" } ] }, { "id": "DS.d372.s1.e2", "type": "protein", "text": [ "LIP" ], "offsets": [ [ 198, 201 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O59952" }, { "db_name": "UniProt", "db_id": "P21764" }, { "db_name": "UniProt", "db_id": "P49081" }, { "db_name": "UniProt", "db_id": "Q06383" }, { "db_name": "UniProt", "db_id": "Q96Q15" } ] }, { "id": "DS.d372.s1.e3", "type": "compound", "text": [ "phosphate" ], "offsets": [ [ 247, 256 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1061" }, { "db_name": "PubChem", "db_id": "167704" }, { "db_name": "PubChem", "db_id": "644102" } ] } ]
[]
[]
[ { "id": "DS.d372.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d372.s0.e2", "arg2_id": "DS.d372.s0.e1", "normalized": [] }, { "id": "DS.d372.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d372.s0.e2", "arg2_id": "DS.d372.s0.e0", "normalized": [] }, { "id": "DS.d372.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d372.s1.e0", "arg2_id": "DS.d372.s1.e2", "normalized": [] }, { "id": "DS.d372.s1.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d372.s1.e0", "arg2_id": "DS.d372.s1.e1", "normalized": [] } ]
DS.d373
18571950
[ { "id": "DS.d373.s0", "type": "", "text": [ "The potential action of galactose as a \"chemical chaperone\": increase of beta galactosidase activity in fibroblasts from an adult GM1-gangliosidosis patient." ], "offsets": [ [ 0, 157 ] ] } ]
[ { "id": "DS.d373.s0.e0", "type": "compound", "text": [ "galactose" ], "offsets": [ [ 24, 33 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6036" }, { "db_name": "PubChem", "db_id": "439353" }, { "db_name": "PubChem", "db_id": "439357" } ] }, { "id": "DS.d373.s0.e1", "type": "protein", "text": [ "beta galactosidase" ], "offsets": [ [ 73, 91 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O33815" }, { "db_name": "UniProt", "db_id": "O52629" }, { "db_name": "UniProt", "db_id": "O52847" }, { "db_name": "UniProt", "db_id": "P00722" }, { "db_name": "UniProt", "db_id": "P00723" }, { "db_name": "UniProt", "db_id": "P06219" }, { "db_name": "UniProt", "db_id": "P0C1Y0" }, { "db_name": "UniProt", "db_id": "P14288" }, { "db_name": "UniProt", "db_id": "P22498" }, { "db_name": "UniProt", "db_id": "P23989" }, { "db_name": "UniProt", "db_id": "P24131" }, { "db_name": "UniProt", "db_id": "P26257" }, { "db_name": "UniProt", "db_id": "P30812" }, { "db_name": "UniProt", "db_id": "P50388" }, { "db_name": "UniProt", "db_id": "P70753" }, { "db_name": "UniProt", "db_id": "P77989" }, { "db_name": "UniProt", "db_id": "P81650" }, { "db_name": "UniProt", "db_id": "Q1G9Z4" }, { "db_name": "UniProt", "db_id": "Q47077" }, { "db_name": "UniProt", "db_id": "Q48727" }, { "db_name": "UniProt", "db_id": "Q56307" }, { "db_name": "UniProt", "db_id": "Q59140" }, { "db_name": "UniProt", "db_id": "Q59750" }, { "db_name": "UniProt", "db_id": "Q9K9C6" } ] } ]
[]
[]
[ { "id": "DS.d373.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d373.s0.e0", "arg2_id": "DS.d373.s0.e1", "normalized": [] } ]
DS.d374
18571954
[ { "id": "DS.d374.s0", "type": "", "text": [ "Citric acid perfusion marginally increased NGF levels to 7.3 fg/microg/ml on average in the upper arm and control axilla." ], "offsets": [ [ 0, 121 ] ] }, { "id": "DS.d374.s1", "type": "", "text": [ "In contrast, perfusion of the inflamed axilla with citric acid significantly enhanced the release of both NGF and BDNF." ], "offsets": [ [ 122, 241 ] ] } ]
[ { "id": "DS.d374.s0.e0", "type": "compound", "text": [ "Citric acid" ], "offsets": [ [ 0, 11 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "311" } ] }, { "id": "DS.d374.s0.e1", "type": "protein", "text": [ "NGF" ], "offsets": [ [ 43, 46 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P21617" }, { "db_name": "UniProt", "db_id": "P34129" }, { "db_name": "UniProt", "db_id": "Q6YBR5" }, { "db_name": "UniProt", "db_id": "Q90W38" } ] }, { "id": "DS.d374.s1.e0", "type": "compound", "text": [ "citric acid" ], "offsets": [ [ 173, 184 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "311" } ] }, { "id": "DS.d374.s1.e1", "type": "protein", "text": [ "NGF" ], "offsets": [ [ 228, 231 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P21617" }, { "db_name": "UniProt", "db_id": "P34129" }, { "db_name": "UniProt", "db_id": "Q6YBR5" }, { "db_name": "UniProt", "db_id": "Q90W38" } ] }, { "id": "DS.d374.s1.e2", "type": "protein", "text": [ "BDNF" ], "offsets": [ [ 236, 240 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O18752" }, { "db_name": "UniProt", "db_id": "O18753" }, { "db_name": "UniProt", "db_id": "O18755" }, { "db_name": "UniProt", "db_id": "O70183" }, { "db_name": "UniProt", "db_id": "O97759" }, { "db_name": "UniProt", "db_id": "P14082" }, { "db_name": "UniProt", "db_id": "P21237" }, { "db_name": "UniProt", "db_id": "P23363" }, { "db_name": "UniProt", "db_id": "P23560" }, { "db_name": "UniProt", "db_id": "P25429" }, { "db_name": "UniProt", "db_id": "P25430" }, { "db_name": "UniProt", "db_id": "P25431" }, { "db_name": "UniProt", "db_id": "P25432" }, { "db_name": "UniProt", "db_id": "Q02193" }, { "db_name": "UniProt", "db_id": "Q06225" }, { "db_name": "UniProt", "db_id": "Q3SAT7" }, { "db_name": "UniProt", "db_id": "Q4L0Y3" }, { "db_name": "UniProt", "db_id": "Q5IS78" }, { "db_name": "UniProt", "db_id": "Q6LCI5" }, { "db_name": "UniProt", "db_id": "Q7YRB4" }, { "db_name": "UniProt", "db_id": "Q90322" }, { "db_name": "UniProt", "db_id": "Q95106" }, { "db_name": "UniProt", "db_id": "Q9TST3" } ] } ]
[]
[]
[ { "id": "DS.d374.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d374.s0.e0", "arg2_id": "DS.d374.s0.e1", "normalized": [] }, { "id": "DS.d374.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d374.s1.e0", "arg2_id": "DS.d374.s1.e1", "normalized": [] }, { "id": "DS.d374.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d374.s1.e0", "arg2_id": "DS.d374.s1.e2", "normalized": [] } ]
DS.d375
18572174
[ { "id": "DS.d375.s0", "type": "", "text": [ "Pitavastatin induces PON1 expression through p44/42 mitogen-activated protein kinase signaling cascade in Huh7 cells." ], "offsets": [ [ 0, 117 ] ] }, { "id": "DS.d375.s1", "type": "", "text": [ "Both PON1 gene promoter activity and PON1 protein expression were elevated by pitavastatin stimulation." ], "offsets": [ [ 118, 221 ] ] }, { "id": "DS.d375.s2", "type": "", "text": [ "Pitavastatin phosphorylated p44/42 MAP kinase." ], "offsets": [ [ 222, 268 ] ] }, { "id": "DS.d375.s3", "type": "", "text": [ "Pitavastatin increased the Sp1-PON1 DNA complex and this effect was attenuated by PD98059." ], "offsets": [ [ 269, 359 ] ] }, { "id": "DS.d375.s4", "type": "", "text": [ "These observations suggest that pitavastatin phosphorylates p44/42 MAP kinase and then activates the transcription of PON1 gene and increases the PON1 protein expression in Huh7 cells." ], "offsets": [ [ 360, 544 ] ] }, { "id": "DS.d375.s5", "type": "", "text": [ "Furthermore, we speculate that pitavastatin affects both the phosphorylation of SREBP-2 and the Sp1 binding to PON1 DNA through the activation of p44/42 MAP kinase signaling cascade." ], "offsets": [ [ 545, 727 ] ] } ]
[ { "id": "DS.d375.s0.e0", "type": "compound", "text": [ "Pitavastatin" ], "offsets": [ [ 0, 12 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5282452" } ] }, { "id": "DS.d375.s0.e1", "type": "protein", "text": [ "PON1" ], "offsets": [ [ 21, 25 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P27169" }, { "db_name": "UniProt", "db_id": "P27170" } ] }, { "id": "DS.d375.s0.e2", "type": "protein", "text": [ "p44" ], "offsets": [ [ 45, 48 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P16342" }, { "db_name": "UniProt", "db_id": "P19751" }, { "db_name": "UniProt", "db_id": "Q66198" }, { "db_name": "UniProt", "db_id": "Q8TCB0" }, { "db_name": "UniProt", "db_id": "Q8V439" }, { "db_name": "UniProt", "db_id": "Q8V6W7" }, { "db_name": "UniProt", "db_id": "Q91A29" }, { "db_name": "UniProt", "db_id": "Q93V93" }, { "db_name": "UniProt", "db_id": "Q9PYA3" } ] }, { "id": "DS.d375.s0.e3", "type": "protein", "text": [ "protein kinase" ], "offsets": [ [ 70, 84 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P00513" }, { "db_name": "UniProt", "db_id": "P25848" } ] }, { "id": "DS.d375.s1.e0", "type": "protein", "text": [ "PON1" ], "offsets": [ [ 123, 127 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P27169" }, { "db_name": "UniProt", "db_id": "P27170" } ] }, { "id": "DS.d375.s1.e1", "type": "protein", "text": [ "PON1" ], "offsets": [ [ 155, 159 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P27169" }, { "db_name": "UniProt", "db_id": "P27170" } ] }, { "id": "DS.d375.s1.e2", "type": "compound", "text": [ "pitavastatin" ], "offsets": [ [ 196, 208 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5282452" } ] }, { "id": "DS.d375.s2.e0", "type": "compound", "text": [ "Pitavastatin" ], "offsets": [ [ 222, 234 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5282452" } ] }, { "id": "DS.d375.s2.e1", "type": "protein", "text": [ "p44" ], "offsets": [ [ 250, 253 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P16342" }, { "db_name": "UniProt", "db_id": "P19751" }, { "db_name": "UniProt", "db_id": "Q66198" }, { "db_name": "UniProt", "db_id": "Q8TCB0" }, { "db_name": "UniProt", "db_id": "Q8V439" }, { "db_name": "UniProt", "db_id": "Q8V6W7" }, { "db_name": "UniProt", "db_id": "Q91A29" }, { "db_name": "UniProt", "db_id": "Q93V93" }, { "db_name": "UniProt", "db_id": "Q9PYA3" } ] }, { "id": "DS.d375.s3.e0", "type": "compound", "text": [ "Pitavastatin" ], "offsets": [ [ 269, 281 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5282452" } ] }, { "id": "DS.d375.s3.e1", "type": "protein", "text": [ "Sp1" ], "offsets": [ [ 296, 299 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O14300" }, { "db_name": "UniProt", "db_id": "O89090" }, { "db_name": "UniProt", "db_id": "P17379" }, { "db_name": "UniProt", "db_id": "Q01714" }, { "db_name": "UniProt", "db_id": "Q85439" }, { "db_name": "UniProt", "db_id": "Q85449" }, { "db_name": "UniProt", "db_id": "Q85451" } ] }, { "id": "DS.d375.s3.e2", "type": "protein", "text": [ "PON1" ], "offsets": [ [ 300, 304 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P27169" }, { "db_name": "UniProt", "db_id": "P27170" } ] }, { "id": "DS.d375.s3.e3", "type": "compound", "text": [ "PD98059" ], "offsets": [ [ 351, 358 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "4713" } ] }, { "id": "DS.d375.s4.e0", "type": "compound", "text": [ "pitavastatin" ], "offsets": [ [ 392, 404 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5282452" } ] }, { "id": "DS.d375.s4.e1", "type": "protein", "text": [ "p44" ], "offsets": [ [ 420, 423 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P16342" }, { "db_name": "UniProt", "db_id": "P19751" }, { "db_name": "UniProt", "db_id": "Q66198" }, { "db_name": "UniProt", "db_id": "Q8TCB0" }, { "db_name": "UniProt", "db_id": "Q8V439" }, { "db_name": "UniProt", "db_id": "Q8V6W7" }, { "db_name": "UniProt", "db_id": "Q91A29" }, { "db_name": "UniProt", "db_id": "Q93V93" }, { "db_name": "UniProt", "db_id": "Q9PYA3" } ] }, { "id": "DS.d375.s4.e2", "type": "protein", "text": [ "PON1" ], "offsets": [ [ 478, 482 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P27169" }, { "db_name": "UniProt", "db_id": "P27170" } ] }, { "id": "DS.d375.s4.e3", "type": "protein", "text": [ "PON1" ], "offsets": [ [ 506, 510 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P27169" }, { "db_name": "UniProt", "db_id": "P27170" } ] }, { "id": "DS.d375.s5.e0", "type": "compound", "text": [ "pitavastatin" ], "offsets": [ [ 576, 588 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5282452" } ] }, { "id": "DS.d375.s5.e1", "type": "protein", "text": [ "SREBP-2" ], "offsets": [ [ 625, 632 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q12772" }, { "db_name": "UniProt", "db_id": "Q60429" } ] }, { "id": "DS.d375.s5.e2", "type": "protein", "text": [ "Sp1" ], "offsets": [ [ 641, 644 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O14300" }, { "db_name": "UniProt", "db_id": "O89090" }, { "db_name": "UniProt", "db_id": "P17379" }, { "db_name": "UniProt", "db_id": "Q01714" }, { "db_name": "UniProt", "db_id": "Q85439" }, { "db_name": "UniProt", "db_id": "Q85449" }, { "db_name": "UniProt", "db_id": "Q85451" } ] }, { "id": "DS.d375.s5.e3", "type": "protein", "text": [ "PON1" ], "offsets": [ [ 656, 660 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P27169" }, { "db_name": "UniProt", "db_id": "P27170" } ] }, { "id": "DS.d375.s5.e4", "type": "protein", "text": [ "p44" ], "offsets": [ [ 691, 694 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P16342" }, { "db_name": "UniProt", "db_id": "P19751" }, { "db_name": "UniProt", "db_id": "Q66198" }, { "db_name": "UniProt", "db_id": "Q8TCB0" }, { "db_name": "UniProt", "db_id": "Q8V439" }, { "db_name": "UniProt", "db_id": "Q8V6W7" }, { "db_name": "UniProt", "db_id": "Q91A29" }, { "db_name": "UniProt", "db_id": "Q93V93" }, { "db_name": "UniProt", "db_id": "Q9PYA3" } ] } ]
[]
[]
[ { "id": "DS.d375.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d375.s0.e0", "arg2_id": "DS.d375.s0.e3", "normalized": [] }, { "id": "DS.d375.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d375.s0.e0", "arg2_id": "DS.d375.s0.e2", "normalized": [] }, { "id": "DS.d375.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d375.s0.e0", "arg2_id": "DS.d375.s0.e1", "normalized": [] }, { "id": "DS.d375.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d375.s1.e2", "arg2_id": "DS.d375.s1.e0", "normalized": [] }, { "id": "DS.d375.s2.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d375.s2.e0", "arg2_id": "DS.d375.s2.e1", "normalized": [] }, { "id": "DS.d375.s3.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d375.s3.e0", "arg2_id": "DS.d375.s3.e1", "normalized": [] }, { "id": "DS.d375.s3.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d375.s3.e3", "arg2_id": "DS.d375.s3.e2", "normalized": [] }, { "id": "DS.d375.s3.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d375.s3.e3", "arg2_id": "DS.d375.s3.e1", "normalized": [] }, { "id": "DS.d375.s3.i3", "type": "compound-protein-interaction", "arg1_id": "DS.d375.s3.e0", "arg2_id": "DS.d375.s3.e2", "normalized": [] }, { "id": "DS.d375.s4.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d375.s4.e0", "arg2_id": "DS.d375.s4.e1", "normalized": [] }, { "id": "DS.d375.s4.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d375.s4.e0", "arg2_id": "DS.d375.s4.e2", "normalized": [] }, { "id": "DS.d375.s5.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d375.s5.e0", "arg2_id": "DS.d375.s5.e4", "normalized": [] }, { "id": "DS.d375.s5.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d375.s5.e0", "arg2_id": "DS.d375.s5.e2", "normalized": [] }, { "id": "DS.d375.s5.i3", "type": "compound-protein-interaction", "arg1_id": "DS.d375.s5.e0", "arg2_id": "DS.d375.s5.e3", "normalized": [] } ]
DS.d376
18573668
[ { "id": "DS.d376.s0", "type": "", "text": [ "Inhibition of cyclooxygenase 2 expression by diallyl sulfide on joint inflammation induced by urate crystal and IL-1beta." ], "offsets": [ [ 0, 121 ] ] }, { "id": "DS.d376.s1", "type": "", "text": [ "Investigation of the effects of diallyl sulfide (DAS), a garlic sulfur compound, on joint tissue inflammatory responses induced by monosodium urate (MSU) crystals and interleukin-1beta (IL-1beta)." ], "offsets": [ [ 122, 318 ] ] } ]
[ { "id": "DS.d376.s0.e0", "type": "protein", "text": [ "cyclooxygenase 2" ], "offsets": [ [ 14, 30 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O02768" }, { "db_name": "UniProt", "db_id": "O19183" }, { "db_name": "UniProt", "db_id": "O62698" }, { "db_name": "UniProt", "db_id": "O62725" }, { "db_name": "UniProt", "db_id": "P27607" }, { "db_name": "UniProt", "db_id": "P35354" }, { "db_name": "UniProt", "db_id": "P35355" }, { "db_name": "UniProt", "db_id": "P70682" }, { "db_name": "UniProt", "db_id": "P79208" }, { "db_name": "UniProt", "db_id": "Q05769" } ] }, { "id": "DS.d376.s0.e1", "type": "compound", "text": [ "diallyl sulfide" ], "offsets": [ [ 45, 60 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "11617" } ] }, { "id": "DS.d376.s0.e2", "type": "protein", "text": [ "IL-1beta" ], "offsets": [ [ 112, 120 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01584" }, { "db_name": "UniProt", "db_id": "P09428" }, { "db_name": "UniProt", "db_id": "P10749" }, { "db_name": "UniProt", "db_id": "P14628" }, { "db_name": "UniProt", "db_id": "P21621" }, { "db_name": "UniProt", "db_id": "P26889" }, { "db_name": "UniProt", "db_id": "P41687" }, { "db_name": "UniProt", "db_id": "P46648" }, { "db_name": "UniProt", "db_id": "P48090" }, { "db_name": "UniProt", "db_id": "P51493" }, { "db_name": "UniProt", "db_id": "P51745" }, { "db_name": "UniProt", "db_id": "P79162" }, { "db_name": "UniProt", "db_id": "P79182" }, { "db_name": "UniProt", "db_id": "Q28292" }, { "db_name": "UniProt", "db_id": "Q28386" }, { "db_name": "UniProt", "db_id": "Q2HZH0" }, { "db_name": "UniProt", "db_id": "Q2MH07" }, { "db_name": "UniProt", "db_id": "Q63264" }, { "db_name": "UniProt", "db_id": "Q6PUD2" }, { "db_name": "UniProt", "db_id": "Q6R2X3" }, { "db_name": "UniProt", "db_id": "Q865X8" }, { "db_name": "UniProt", "db_id": "Q8WNR2" }, { "db_name": "UniProt", "db_id": "Q9WVG1" }, { "db_name": "UniProt", "db_id": "Q9XS77" } ] }, { "id": "DS.d376.s1.e0", "type": "compound", "text": [ "diallyl sulfide" ], "offsets": [ [ 154, 169 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "11617" } ] }, { "id": "DS.d376.s1.e2", "type": "compound", "text": [ "monosodium urate" ], "offsets": [ [ 253, 269 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1175" } ] }, { "id": "DS.d376.s1.e3", "type": "protein", "text": [ "IL-1beta" ], "offsets": [ [ 308, 316 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01584" }, { "db_name": "UniProt", "db_id": "P09428" }, { "db_name": "UniProt", "db_id": "P10749" }, { "db_name": "UniProt", "db_id": "P14628" }, { "db_name": "UniProt", "db_id": "P21621" }, { "db_name": "UniProt", "db_id": "P26889" }, { "db_name": "UniProt", "db_id": "P41687" }, { "db_name": "UniProt", "db_id": "P46648" }, { "db_name": "UniProt", "db_id": "P48090" }, { "db_name": "UniProt", "db_id": "P51493" }, { "db_name": "UniProt", "db_id": "P51745" }, { "db_name": "UniProt", "db_id": "P79162" }, { "db_name": "UniProt", "db_id": "P79182" }, { "db_name": "UniProt", "db_id": "Q28292" }, { "db_name": "UniProt", "db_id": "Q28386" }, { "db_name": "UniProt", "db_id": "Q2HZH0" }, { "db_name": "UniProt", "db_id": "Q2MH07" }, { "db_name": "UniProt", "db_id": "Q63264" }, { "db_name": "UniProt", "db_id": "Q6PUD2" }, { "db_name": "UniProt", "db_id": "Q6R2X3" }, { "db_name": "UniProt", "db_id": "Q865X8" }, { "db_name": "UniProt", "db_id": "Q8WNR2" }, { "db_name": "UniProt", "db_id": "Q9WVG1" }, { "db_name": "UniProt", "db_id": "Q9XS77" } ] } ]
[]
[]
[ { "id": "DS.d376.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d376.s0.e1", "arg2_id": "DS.d376.s0.e0", "normalized": [] } ]
DS.d377
18574025
[ { "id": "DS.d377.s0", "type": "", "text": [ "Genetic variants of cytochrome P450 2C9 (CYP2C9) and vitamin K epoxide reductase (VKORC1) are known to influence warfarin dose, but the effect of other genes has not been fully elucidated." ], "offsets": [ [ 0, 188 ] ] }, { "id": "DS.d377.s1", "type": "", "text": [ "In conclusion, CYP2C9 and VKORC1 significantly influenced warfarin dose and predicted individuals predisposed to unstable anticoagulation." ], "offsets": [ [ 189, 327 ] ] } ]
[ { "id": "DS.d377.s0.e0", "type": "protein", "text": [ "cytochrome P450 2C9" ], "offsets": [ [ 20, 39 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P11712" } ] }, { "id": "DS.d377.s0.e1", "type": "protein", "text": [ "CYP2C9" ], "offsets": [ [ 41, 47 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P11712" } ] }, { "id": "DS.d377.s0.e2", "type": "protein", "text": [ "VKORC1" ], "offsets": [ [ 82, 88 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q6B4J2" }, { "db_name": "UniProt", "db_id": "Q9BQB6" } ] }, { "id": "DS.d377.s0.e3", "type": "compound", "text": [ "warfarin" ], "offsets": [ [ 113, 121 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "54678486" } ] }, { "id": "DS.d377.s1.e0", "type": "protein", "text": [ "CYP2C9" ], "offsets": [ [ 204, 210 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P11712" } ] }, { "id": "DS.d377.s1.e1", "type": "protein", "text": [ "VKORC1" ], "offsets": [ [ 215, 221 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q6B4J2" }, { "db_name": "UniProt", "db_id": "Q9BQB6" } ] }, { "id": "DS.d377.s1.e2", "type": "compound", "text": [ "warfarin" ], "offsets": [ [ 247, 255 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "54678486" } ] } ]
[]
[]
[ { "id": "DS.d377.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d377.s0.e3", "arg2_id": "DS.d377.s0.e0", "normalized": [] }, { "id": "DS.d377.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d377.s0.e3", "arg2_id": "DS.d377.s0.e2", "normalized": [] }, { "id": "DS.d377.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d377.s0.e3", "arg2_id": "DS.d377.s0.e1", "normalized": [] }, { "id": "DS.d377.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d377.s1.e2", "arg2_id": "DS.d377.s1.e1", "normalized": [] }, { "id": "DS.d377.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d377.s1.e2", "arg2_id": "DS.d377.s1.e0", "normalized": [] } ]
DS.d378
18574490
[ { "id": "DS.d378.s0", "type": "", "text": [ "BMI and testosterone levels were evaluated for their ability to predict overall survival (OS) and prostate-specific antigen (PSA) declines in the TAX327 clinical trial, an international phase III randomized trial of one of the two schedules of docetaxel and prednisone compared with mitoxantrone and prednisone." ], "offsets": [ [ 0, 311 ] ] }, { "id": "DS.d378.s1", "type": "", "text": [ "In multivariate analysis, neither BMI, presence of obesity, nor baseline testosterone was significantly associated with OS or PSA declines." ], "offsets": [ [ 312, 451 ] ] } ]
[ { "id": "DS.d378.s0.e0", "type": "compound", "text": [ "testosterone" ], "offsets": [ [ 8, 20 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6013" } ] }, { "id": "DS.d378.s0.e1", "type": "protein", "text": [ "PSA" ], "offsets": [ [ 125, 128 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P07288" }, { "db_name": "UniProt", "db_id": "P10658" }, { "db_name": "UniProt", "db_id": "P33619" }, { "db_name": "UniProt", "db_id": "P55786" }, { "db_name": "UniProt", "db_id": "Q11011" }, { "db_name": "UniProt", "db_id": "Q6DT45" }, { "db_name": "UniProt", "db_id": "Q9Y617" } ] }, { "id": "DS.d378.s0.e2", "type": "compound", "text": [ "docetaxel" ], "offsets": [ [ 244, 253 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "148124" } ] }, { "id": "DS.d378.s0.e3", "type": "compound", "text": [ "prednisone" ], "offsets": [ [ 258, 268 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5865" } ] }, { "id": "DS.d378.s0.e4", "type": "compound", "text": [ "mitoxantrone" ], "offsets": [ [ 283, 295 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "4212" } ] }, { "id": "DS.d378.s0.e5", "type": "compound", "text": [ "prednisone" ], "offsets": [ [ 300, 310 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5865" } ] }, { "id": "DS.d378.s1.e0", "type": "compound", "text": [ "testosterone" ], "offsets": [ [ 385, 397 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6013" } ] }, { "id": "DS.d378.s1.e1", "type": "protein", "text": [ "PSA" ], "offsets": [ [ 438, 441 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P07288" }, { "db_name": "UniProt", "db_id": "P10658" }, { "db_name": "UniProt", "db_id": "P33619" }, { "db_name": "UniProt", "db_id": "P55786" }, { "db_name": "UniProt", "db_id": "Q11011" }, { "db_name": "UniProt", "db_id": "Q6DT45" }, { "db_name": "UniProt", "db_id": "Q9Y617" } ] } ]
[]
[]
[]
DS.d379
18574670
[ { "id": "DS.d379.s0", "type": "", "text": [ "The interaction between PAF and the platelet agonists ADP, thrombin and convulxin was analyzed in vitro in whole blood with the use of flow cytometry and was further characterized with the use of receptor antagonists to PAF (ABT-491), P2Y1 (MRS-2179), and P2Y12 (cangrelor) as well as a monoclonal anti-PSGL-1 antibody (anti-CD162)." ], "offsets": [ [ 0, 332 ] ] } ]
[ { "id": "DS.d379.s0.e0", "type": "protein", "text": [ "thrombin" ], "offsets": [ [ 59, 67 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P84122" } ] }, { "id": "DS.d379.s0.e1", "type": "compound", "text": [ "MRS-2179" ], "offsets": [ [ 241, 249 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5311303" } ] }, { "id": "DS.d379.s0.e2", "type": "compound", "text": [ "cangrelor" ], "offsets": [ [ 263, 272 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "9854012" } ] } ]
[]
[]
[]
DS.d380
18575957
[ { "id": "DS.d380.s0", "type": "", "text": [ "Aim The present study sought insight into the effects of remifentanyl and fentanyl on LPS-induced release of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha) and IL-10 in human whole blood." ], "offsets": [ [ 0, 202 ] ] }, { "id": "DS.d380.s1", "type": "", "text": [ "Effects of remifentanyl and fentanyl on spontaneous and endotoxin (lipopolysaccharide ; 100 ng ml(-1))-stimulated cytokine release were studied in whole blood from volunteers (n = 10) cultured for 6 h. Results IL-6, TNF-alpha and IL-10 0.01)." ], "offsets": [ [ 203, 445 ] ] }, { "id": "DS.d380.s2", "type": "", "text": [ "Remifentanyl and fentanyl could inhibit the expressions of IL-6, TNF-alpha and IL-10 induced by LPS." ], "offsets": [ [ 446, 546 ] ] } ]
[ { "id": "DS.d380.s0.e0", "type": "compound", "text": [ "remifentanyl" ], "offsets": [ [ 57, 69 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "60815" } ] }, { "id": "DS.d380.s0.e2", "type": "protein", "text": [ "interleukin-6" ], "offsets": [ [ 109, 122 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P41693" } ] }, { "id": "DS.d380.s0.e3", "type": "protein", "text": [ "IL-6" ], "offsets": [ [ 124, 128 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O35736" }, { "db_name": "UniProt", "db_id": "P05231" }, { "db_name": "UniProt", "db_id": "P08505" }, { "db_name": "UniProt", "db_id": "P20607" }, { "db_name": "UniProt", "db_id": "P26892" }, { "db_name": "UniProt", "db_id": "P26893" }, { "db_name": "UniProt", "db_id": "P29455" }, { "db_name": "UniProt", "db_id": "P41323" }, { "db_name": "UniProt", "db_id": "P41683" }, { "db_name": "UniProt", "db_id": "P41693" }, { "db_name": "UniProt", "db_id": "P46650" }, { "db_name": "UniProt", "db_id": "P51494" }, { "db_name": "UniProt", "db_id": "P79341" }, { "db_name": "UniProt", "db_id": "Q25BC2" }, { "db_name": "UniProt", "db_id": "Q28319" }, { "db_name": "UniProt", "db_id": "Q28747" }, { "db_name": "UniProt", "db_id": "Q28819" }, { "db_name": "UniProt", "db_id": "Q2MH06" }, { "db_name": "UniProt", "db_id": "Q5I6E3" }, { "db_name": "UniProt", "db_id": "Q6V919" }, { "db_name": "UniProt", "db_id": "Q865W7" }, { "db_name": "UniProt", "db_id": "Q865X6" }, { "db_name": "UniProt", "db_id": "Q8MKH0" }, { "db_name": "UniProt", "db_id": "Q95181" }, { "db_name": "UniProt", "db_id": "Q9MZR1" }, { "db_name": "UniProt", "db_id": "Q9XT80" } ] }, { "id": "DS.d380.s0.e4", "type": "protein", "text": [ "tumor necrosis factor" ], "offsets": [ [ 131, 152 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q8JFG3" } ] }, { "id": "DS.d380.s0.e5", "type": "protein", "text": [ "TNF-alpha" ], "offsets": [ [ 160, 169 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O35734" }, { "db_name": "UniProt", "db_id": "O77510" }, { "db_name": "UniProt", "db_id": "O77764" }, { "db_name": "UniProt", "db_id": "P01375" }, { "db_name": "UniProt", "db_id": "P04924" }, { "db_name": "UniProt", "db_id": "P06804" }, { "db_name": "UniProt", "db_id": "P13296" }, { "db_name": "UniProt", "db_id": "P16599" }, { "db_name": "UniProt", "db_id": "P19101" }, { "db_name": "UniProt", "db_id": "P23383" }, { "db_name": "UniProt", "db_id": "P23563" }, { "db_name": "UniProt", "db_id": "P29553" }, { "db_name": "UniProt", "db_id": "P33620" }, { "db_name": "UniProt", "db_id": "P36939" }, { "db_name": "UniProt", "db_id": "P48094" }, { "db_name": "UniProt", "db_id": "P51435" }, { "db_name": "UniProt", "db_id": "P51742" }, { "db_name": "UniProt", "db_id": "P51743" }, { "db_name": "UniProt", "db_id": "P59684" }, { "db_name": "UniProt", "db_id": "P59693" }, { "db_name": "UniProt", "db_id": "P59694" }, { "db_name": "UniProt", "db_id": "P59695" }, { "db_name": "UniProt", "db_id": "P79337" }, { "db_name": "UniProt", "db_id": "P79374" }, { "db_name": "UniProt", "db_id": "Q06599" }, { "db_name": "UniProt", "db_id": "Q19LH4" }, { "db_name": "UniProt", "db_id": "Q1G1A2" }, { "db_name": "UniProt", "db_id": "Q1WM27" }, { "db_name": "UniProt", "db_id": "Q2MH05" }, { "db_name": "UniProt", "db_id": "Q539C2" }, { "db_name": "UniProt", "db_id": "Q75N23" }, { "db_name": "UniProt", "db_id": "Q8HZD9" }, { "db_name": "UniProt", "db_id": "Q8JFG3" }, { "db_name": "UniProt", "db_id": "Q8MKG8" }, { "db_name": "UniProt", "db_id": "Q8WNR1" }, { "db_name": "UniProt", "db_id": "Q9BEA1" } ] }, { "id": "DS.d380.s0.e6", "type": "protein", "text": [ "IL-10" ], "offsets": [ [ 175, 180 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O46673" }, { "db_name": "UniProt", "db_id": "O97798" }, { "db_name": "UniProt", "db_id": "P18893" }, { "db_name": "UniProt", "db_id": "P22301" }, { "db_name": "UniProt", "db_id": "P29456" }, { "db_name": "UniProt", "db_id": "P43480" }, { "db_name": "UniProt", "db_id": "P46651" }, { "db_name": "UniProt", "db_id": "P47965" }, { "db_name": "UniProt", "db_id": "P48411" }, { "db_name": "UniProt", "db_id": "P51496" }, { "db_name": "UniProt", "db_id": "P51497" }, { "db_name": "UniProt", "db_id": "P51746" }, { "db_name": "UniProt", "db_id": "P55029" }, { "db_name": "UniProt", "db_id": "P79338" }, { "db_name": "UniProt", "db_id": "Q0Z972" }, { "db_name": "UniProt", "db_id": "Q25BC1" }, { "db_name": "UniProt", "db_id": "Q28374" }, { "db_name": "UniProt", "db_id": "Q29055" }, { "db_name": "UniProt", "db_id": "Q29408" }, { "db_name": "UniProt", "db_id": "Q2PE73" }, { "db_name": "UniProt", "db_id": "Q5Q0V6" }, { "db_name": "UniProt", "db_id": "Q865X4" }, { "db_name": "UniProt", "db_id": "Q8MKG9" }, { "db_name": "UniProt", "db_id": "Q9JHK7" }, { "db_name": "UniProt", "db_id": "Q9TSJ4" }, { "db_name": "UniProt", "db_id": "Q9Z1Y5" } ] }, { "id": "DS.d380.s1.e0", "type": "compound", "text": [ "remifentanyl" ], "offsets": [ [ 214, 226 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "60815" } ] }, { "id": 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[]
[]
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DS.d381
18577298
[ { "id": "DS.d381.s0", "type": "", "text": [ "This reduction was associated with the storage of decreased TAG and increased glycogen, which was a result of enhanced tyrosine phosphorylation of anti-insulin receptor substrate-2 and serine473 phosphporylation of protein kinase B (PKB, Akt)." ], "offsets": [ [ 0, 243 ] ] }, { "id": "DS.d381.s1", "type": "", "text": [ "Improved hepatic insulin signalling led to decreased phosphoenolpyruvate carboxykinase expression and reduced hepatic glucose output accordingly." ], "offsets": [ [ 244, 389 ] ] } ]
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[]
[]
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DS.d382
18577871
[ { "id": "DS.d382.s0", "type": "", "text": [ "These data provide evidence that CMEC express CaSR, which is able to respond to physiological agonists by mobilizing Ca(2+) from intracellular InsP(3)-sensitive stores." ], "offsets": [ [ 0, 168 ] ] } ]
[ { "id": "DS.d382.s0.e0", "type": "protein", "text": [ "CaSR" ], "offsets": [ [ 46, 50 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O62714" }, { "db_name": "UniProt", "db_id": "P35384" }, { "db_name": "UniProt", "db_id": "P41180" }, { "db_name": "UniProt", "db_id": "P48442" }, { "db_name": "UniProt", "db_id": "Q9QY96" } ] }, { "id": "DS.d382.s0.e1", "type": "compound", "text": [ "Ca(2" ], "offsets": [ [ 117, 121 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "271" } ] } ]
[]
[]
[ { "id": "DS.d382.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d382.s0.e1", "arg2_id": "DS.d382.s0.e0", "normalized": [] } ]
DS.d383
18579232
[ { "id": "DS.d383.s0", "type": "", "text": [ "Inhibition of these enzymes shows that chagasic autoantibodies up-regulation of COX-2/iNOS mRNA level is under the control of endogenous iNO/cGMP signaling system." ], "offsets": [ [ 0, 163 ] ] } ]
[ { "id": "DS.d383.s0.e0", "type": "protein", "text": [ "COX-2" ], "offsets": [ [ 80, 85 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O02768" }, { "db_name": "UniProt", "db_id": "O19183" }, { "db_name": "UniProt", "db_id": "O62698" }, { "db_name": "UniProt", "db_id": "O62725" }, { "db_name": "UniProt", "db_id": "P27607" }, { "db_name": "UniProt", "db_id": "P35354" }, { "db_name": "UniProt", "db_id": "P35355" }, { "db_name": "UniProt", "db_id": "P70682" }, { "db_name": "UniProt", "db_id": "P79208" }, { "db_name": "UniProt", "db_id": "Q05769" } ] }, { "id": "DS.d383.s0.e1", "type": "protein", "text": [ "iNOS" ], "offsets": [ [ 86, 90 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O19114" }, { "db_name": "UniProt", "db_id": "O46660" }, { "db_name": "UniProt", "db_id": "O54705" }, { "db_name": "UniProt", "db_id": "O62699" }, { "db_name": "UniProt", "db_id": "P29477" }, { "db_name": "UniProt", "db_id": "P35228" }, { "db_name": "UniProt", "db_id": "P79290" }, { "db_name": "UniProt", "db_id": "Q06518" }, { "db_name": "UniProt", "db_id": "Q27995" }, { "db_name": "UniProt", "db_id": "Q28314" }, { "db_name": "UniProt", "db_id": "Q90703" }, { "db_name": "UniProt", "db_id": "Q92037" }, { "db_name": "UniProt", "db_id": "Q92091" } ] }, { "id": "DS.d383.s0.e3", "type": "compound", "text": [ "cGMP" ], "offsets": [ [ 141, 145 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "24316" } ] } ]
[]
[]
[ { "id": "DS.d383.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d383.s0.e3", "arg2_id": "DS.d383.s0.e0", "normalized": [] }, { "id": "DS.d383.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d383.s0.e3", "arg2_id": "DS.d383.s0.e1", "normalized": [] } ]
DS.d384
18580872
[ { "id": "DS.d384.s0", "type": "", "text": [ "Pre-synaptic CB1Rs inhibit neurotransmitter release, suggesting that CB1R activation during extinction may decrease CCK peptide release as well as GABA release." ], "offsets": [ [ 0, 160 ] ] } ]
[ { "id": "DS.d384.s0.e0", "type": "protein", "text": [ "CB1Rs" ], "offsets": [ [ 13, 18 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P52451" } ] }, { "id": "DS.d384.s0.e1", "type": "protein", "text": [ "CB1R" ], "offsets": [ [ 13, 17 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P52451" } ] }, { "id": "DS.d384.s0.e2", "type": "protein", "text": [ "CCK" ], "offsets": [ [ 116, 119 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O57312" }, { "db_name": "UniProt", "db_id": "O93464" }, { "db_name": "UniProt", "db_id": "P01355" }, { "db_name": "UniProt", "db_id": "P01356" }, { "db_name": "UniProt", "db_id": "P06307" }, { "db_name": "UniProt", "db_id": "P09240" }, { "db_name": "UniProt", "db_id": "P0C229" }, { "db_name": "UniProt", "db_id": "P23362" }, { "db_name": "UniProt", "db_id": "P41520" }, { "db_name": "UniProt", "db_id": "P50144" }, { "db_name": "UniProt", "db_id": "P50145" }, { "db_name": "UniProt", "db_id": "P68125" }, { "db_name": "UniProt", "db_id": "P68126" }, { "db_name": "UniProt", "db_id": "P80344" }, { "db_name": "UniProt", "db_id": "P80345" }, { "db_name": "UniProt", "db_id": "Q9PU29" }, { "db_name": "UniProt", "db_id": "Q9PU41" } ] }, { "id": "DS.d384.s0.e3", "type": "compound", "text": [ "GABA" ], "offsets": [ [ 147, 151 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "119" } ] } ]
[]
[]
[ { "id": "DS.d384.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d384.s0.e3", "arg2_id": "DS.d384.s0.e1", "normalized": [] }, { "id": "DS.d384.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d384.s0.e3", "arg2_id": "DS.d384.s0.e0", "normalized": [] } ]
DS.d385
18580876
[ { "id": "DS.d385.s0", "type": "", "text": [ "Acute cocaine, through D(2) dopamine receptors, induced a dose-response increase in FADD protein in the cortex, with opposite effects over pFADD (Ser191/194), and no induction of apoptotic cell death (poly-(ADP-ribose) polymerase cleavage)." ], "offsets": [ [ 0, 240 ] ] }, { "id": "DS.d385.s1", "type": "", "text": [ "FADD was increased by cocaine in cytosol (approximately 142%), membranes (approximately 23%) and nucleus (approximately 54%)." ], "offsets": [ [ 241, 366 ] ] }, { "id": "DS.d385.s2", "type": "", "text": [ "In a second experiment, possible FADD differences were investigated in rats selectively bred for differential responsiveness to novelty, propensity for drug-seeking and cocaine sensitization." ], "offsets": [ [ 367, 558 ] ] } ]
[ { "id": "DS.d385.s0.e0", "type": "compound", "text": [ "cocaine" ], "offsets": [ [ 6, 13 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2826" }, { "db_name": "PubChem", "db_id": "5760" }, { "db_name": "PubChem", "db_id": "439497" }, { "db_name": "PubChem", "db_id": "446220" }, { "db_name": "PubChem", "db_id": "644017" }, { "db_name": "PubChem", "db_id": "54613779" } ] }, { "id": "DS.d385.s0.e1", "type": "protein", "text": [ "D(2) dopamine receptors" ], "offsets": [ [ 23, 46 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O73810" }, { "db_name": "UniProt", "db_id": "P14416" }, { "db_name": "UniProt", "db_id": "P20288" }, { "db_name": "UniProt", "db_id": "P52702" }, { "db_name": "UniProt", "db_id": "P60026" }, { "db_name": "UniProt", "db_id": "P61168" }, { "db_name": "UniProt", "db_id": "P61169" }, { "db_name": "UniProt", "db_id": "Q6TLI9" }, { "db_name": "UniProt", "db_id": "Q9GJU1" } ] }, { "id": "DS.d385.s0.e2", "type": "protein", "text": [ "FADD protein" ], "offsets": [ [ 84, 96 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q13158" }, { "db_name": "UniProt", "db_id": "Q61160" } ] }, { "id": "DS.d385.s1.e0", "type": "protein", "text": [ "FADD" ], "offsets": [ [ 241, 245 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P46310" }, { "db_name": "UniProt", "db_id": "Q13158" } ] }, { "id": "DS.d385.s1.e1", "type": "compound", "text": [ "cocaine" ], "offsets": [ [ 263, 270 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2826" }, { "db_name": "PubChem", "db_id": "5760" }, { "db_name": "PubChem", "db_id": "439497" }, { "db_name": "PubChem", "db_id": "446220" }, { "db_name": "PubChem", "db_id": "644017" }, { "db_name": "PubChem", "db_id": "54613779" } ] }, { "id": "DS.d385.s2.e0", "type": "protein", "text": [ "FADD" ], "offsets": [ [ 400, 404 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P46310" }, { "db_name": "UniProt", "db_id": "Q13158" } ] }, { "id": "DS.d385.s2.e1", "type": "compound", "text": [ "cocaine" ], "offsets": [ [ 536, 543 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2826" }, { "db_name": "PubChem", "db_id": "5760" }, { "db_name": "PubChem", "db_id": "439497" }, { "db_name": "PubChem", "db_id": "446220" }, { "db_name": "PubChem", "db_id": "644017" }, { "db_name": "PubChem", "db_id": "54613779" } ] } ]
[]
[]
[ { "id": "DS.d385.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d385.s0.e0", "arg2_id": "DS.d385.s0.e2", "normalized": [] }, { "id": "DS.d385.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d385.s0.e0", "arg2_id": "DS.d385.s0.e1", "normalized": [] }, { "id": "DS.d385.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d385.s1.e1", "arg2_id": "DS.d385.s1.e0", "normalized": [] } ]
DS.d386
18581264
[ { "id": "DS.d386.s0", "type": "", "text": [ "Lignin peroxidases have the unique ability to catalyze oxidative cleavage of C-C bonds and ether (C-O-C) bonds in non-phenolic aromatic substrates of high redox potential." ], "offsets": [ [ 0, 171 ] ] }, { "id": "DS.d386.s1", "type": "", "text": [ "Manganese peroxidases oxidize Mn(II) to Mn(III), which facilitates the degradation of phenolic compounds or, in turn, oxidizes a second mediator for the breakdown of non-phenolic compounds." ], "offsets": [ [ 172, 361 ] ] }, { "id": "DS.d386.s2", "type": "", "text": [ "Laccases are multi-copper-containing proteins that catalyze the oxidation of phenolic substrates with concomitant reduction of molecular oxygen to water." ], "offsets": [ [ 362, 515 ] ] } ]
[ { "id": "DS.d386.s0.e0", "type": "protein", "text": [ "Lignin peroxidases" ], "offsets": [ [ 0, 18 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P06181" }, { "db_name": "UniProt", "db_id": "P11542" }, { "db_name": "UniProt", "db_id": "P11543" }, { "db_name": "UniProt", "db_id": "P20010" }, { "db_name": "UniProt", "db_id": "P20011" }, { "db_name": "UniProt", "db_id": "P20012" }, { "db_name": "UniProt", "db_id": "P20013" }, { "db_name": "UniProt", "db_id": "P21764" }, { "db_name": "UniProt", "db_id": "P31837" }, { "db_name": "UniProt", "db_id": "P31838" }, { "db_name": "UniProt", "db_id": "P49012" }, { "db_name": "UniProt", "db_id": "P50622" } ] }, { "id": "DS.d386.s0.e1", "type": "compound", "text": [ "ether" ], "offsets": [ [ 91, 96 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "3283" }, { "db_name": "PubChem", "db_id": "5382654" } ] }, { "id": "DS.d386.s1.e0", "type": "protein", "text": [ "peroxidases" ], "offsets": [ [ 182, 193 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P15984" }, { "db_name": "UniProt", "db_id": "P16147" }, { "db_name": "UniProt", "db_id": "P84714" } ] }, { "id": "DS.d386.s1.e1", "type": "compound", "text": [ "Mn(II" ], "offsets": [ [ 202, 207 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "27854" } ] }, { "id": "DS.d386.s1.e2", "type": "compound", "text": [ "Mn(III" ], "offsets": [ [ 212, 218 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "105130" } ] }, { "id": "DS.d386.s2.e0", "type": "protein", "text": [ "Laccases" ], "offsets": [ [ 362, 370 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q12570" } ] }, { "id": "DS.d386.s2.e1", "type": "compound", "text": [ "copper" ], "offsets": [ [ 381, 387 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "23978" } ] }, { "id": "DS.d386.s2.e2", "type": "compound", "text": [ "oxygen" ], "offsets": [ [ 499, 505 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "977" } ] } ]
[]
[]
[ { "id": "DS.d386.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d386.s0.e1", "arg2_id": "DS.d386.s0.e0", "normalized": [] }, { "id": "DS.d386.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d386.s1.e2", "arg2_id": "DS.d386.s1.e0", "normalized": [] }, { "id": "DS.d386.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d386.s1.e1", "arg2_id": "DS.d386.s1.e0", "normalized": [] }, { "id": "DS.d386.s2.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d386.s2.e1", "arg2_id": "DS.d386.s2.e0", "normalized": [] }, { "id": "DS.d386.s2.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d386.s2.e2", "arg2_id": "DS.d386.s2.e0", "normalized": [] } ]
DS.d387
18581270
[ { "id": "DS.d387.s0", "type": "", "text": [ "The co-expression of SERT with M6B results in a significant decrease in SERT-mediated serotonin uptake caused by a down-regulation of SERT surface expression." ], "offsets": [ [ 0, 158 ] ] } ]
[ { "id": "DS.d387.s0.e0", "type": "protein", "text": [ "SERT" ], "offsets": [ [ 21, 25 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P31645" }, { "db_name": "UniProt", "db_id": "Q9XT49" } ] }, { "id": "DS.d387.s0.e1", "type": "protein", "text": [ "M6B" ], "offsets": [ [ 31, 34 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q13491" }, { "db_name": "UniProt", "db_id": "Q5R603" } ] }, { "id": "DS.d387.s0.e2", "type": "protein", "text": [ "SERT" ], "offsets": [ [ 72, 76 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P31645" }, { "db_name": "UniProt", "db_id": "Q9XT49" } ] }, { "id": "DS.d387.s0.e3", "type": "compound", "text": [ "serotonin" ], "offsets": [ [ 86, 95 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5202" } ] }, { "id": "DS.d387.s0.e4", "type": "protein", "text": [ "SERT" ], "offsets": [ [ 72, 76 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P31645" }, { "db_name": "UniProt", "db_id": "Q9XT49" } ] } ]
[]
[]
[ { "id": "DS.d387.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d387.s0.e3", "arg2_id": "DS.d387.s0.e0", "normalized": [] }, { "id": "DS.d387.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d387.s0.e3", "arg2_id": "DS.d387.s0.e1", "normalized": [] } ]
DS.d388
18582556
[ { "id": "DS.d388.s0", "type": "", "text": [ "Hence, resistance to cancer in old Snell dwarf mice may be mediated by neuroendocrine factors that reduce glucose utilization besides elevated adiponectin, reduced IGF-I and a lack of GH, PRL and TSH, seen in both Snell and Ames dwarf mice." ], "offsets": [ [ 0, 240 ] ] } ]
[ { "id": "DS.d388.s0.e0", "type": "compound", "text": [ "glucose" ], "offsets": [ [ 106, 113 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "206" }, { "db_name": "PubChem", "db_id": "5793" }, { "db_name": "PubChem", "db_id": "64689" }, { "db_name": "PubChem", "db_id": "79025" } ] }, { "id": "DS.d388.s0.e1", "type": "protein", "text": [ "IGF-I" ], "offsets": [ [ 164, 169 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P05017" }, { "db_name": "UniProt", "db_id": "P07455" }, { "db_name": "UniProt", "db_id": "P08025" }, { "db_name": "UniProt", "db_id": "P10763" }, { "db_name": "UniProt", "db_id": "P16545" }, { "db_name": "UniProt", "db_id": "P17085" }, { "db_name": "UniProt", "db_id": "P17647" }, { "db_name": "UniProt", "db_id": "P18254" }, { "db_name": "UniProt", "db_id": "P33712" }, { "db_name": "UniProt", "db_id": "P51457" }, { "db_name": "UniProt", "db_id": "P51458" }, { "db_name": "UniProt", "db_id": "P51462" }, { "db_name": "UniProt", "db_id": "Q02815" }, { "db_name": "UniProt", "db_id": "Q28933" }, { "db_name": "UniProt", "db_id": "Q68LC0" }, { "db_name": "UniProt", "db_id": "Q6GUL6" }, { "db_name": "UniProt", "db_id": "Q6IVA5" }, { "db_name": "UniProt", "db_id": "Q6JLX1" }, { "db_name": "UniProt", "db_id": "Q95222" } ] }, { "id": "DS.d388.s0.e2", "type": "protein", "text": [ "PRL" ], "offsets": [ [ 188, 191 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O62781" }, { "db_name": "UniProt", "db_id": "O62819" }, { "db_name": "UniProt", "db_id": "O93337" }, { "db_name": "UniProt", "db_id": "P01236" }, { "db_name": "UniProt", "db_id": "P01237" }, { "db_name": "UniProt", "db_id": "P01238" }, { "db_name": "UniProt", "db_id": "P01239" }, { "db_name": "UniProt", "db_id": "P01240" }, { "db_name": "UniProt", "db_id": "P06879" }, { "db_name": "UniProt", "db_id": "P09585" }, { "db_name": "UniProt", "db_id": "P10765" }, { "db_name": "UniProt", "db_id": "P12420" }, { "db_name": "UniProt", "db_id": "P14676" }, { "db_name": "UniProt", "db_id": "P17572" }, { "db_name": "UniProt", "db_id": "P21993" }, { "db_name": "UniProt", "db_id": "P22393" }, { "db_name": "UniProt", "db_id": "P29234" }, { "db_name": "UniProt", "db_id": "P29235" }, { "db_name": "UniProt", "db_id": "P33089" }, { "db_name": "UniProt", "db_id": "P33090" }, { "db_name": "UniProt", "db_id": "P33091" }, { "db_name": "UniProt", "db_id": "P33096" }, { "db_name": "UniProt", "db_id": "P34181" }, { "db_name": "UniProt", "db_id": "P35395" }, { "db_name": "UniProt", "db_id": "P37884" }, { "db_name": "UniProt", "db_id": "P40424" }, { "db_name": "UniProt", "db_id": "P43001" }, { "db_name": "UniProt", "db_id": "P43299" }, { "db_name": "UniProt", "db_id": "P46403" }, { "db_name": "UniProt", "db_id": "P48096" }, { "db_name": "UniProt", "db_id": "P48249" }, { "db_name": "UniProt", "db_id": "P51904" }, { "db_name": "UniProt", "db_id": "P55151" }, { "db_name": "UniProt", "db_id": "P87495" }, { "db_name": "UniProt", "db_id": "Q28318" }, { "db_name": "UniProt", "db_id": "Q28632" }, { "db_name": "UniProt", "db_id": "Q3Y4G6" }, { "db_name": "UniProt", "db_id": "Q6UC74" }, { "db_name": "UniProt", "db_id": "Q7ZZV3" }, { "db_name": "UniProt", "db_id": "Q8HXS1" }, { "db_name": "UniProt", "db_id": "Q9QZL1" }, { "db_name": "UniProt", "db_id": "Q9YGV6" } ] } ]
[]
[]
[]
DS.d389
18582992
[ { "id": "DS.d389.s0", "type": "", "text": [ "Therefore, cinacalcet, which inhibit the production of parathormone by negative feedback, was considered a treatment option to control the evolution of calciphylaxis in a dialysed patient suffering from cholangiocarcinoma." ], "offsets": [ [ 0, 222 ] ] } ]
[ { "id": "DS.d389.s0.e0", "type": "compound", "text": [ "cinacalcet" ], "offsets": [ [ 11, 21 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "156419" } ] }, { "id": "DS.d389.s0.e1", "type": "protein", "text": [ "parathormone" ], "offsets": [ [ 55, 67 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01270" } ] } ]
[]
[]
[ { "id": "DS.d389.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d389.s0.e0", "arg2_id": "DS.d389.s0.e1", "normalized": [] } ]
DS.d390
18583434
[ { "id": "DS.d390.s0", "type": "", "text": [ "Glucose levels and hormones (Peptide YY(3-36), glucagon-like peptide-1 (GLP-1), leptin, ghrelin, insulin) that regulate EI were measured." ], "offsets": [ [ 0, 137 ] ] } ]
[ { "id": "DS.d390.s0.e0", "type": "compound", "text": [ "Glucose" ], "offsets": [ [ 0, 7 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "206" }, { "db_name": "PubChem", "db_id": "5793" }, { "db_name": "PubChem", "db_id": "64689" }, { "db_name": "PubChem", "db_id": "79025" } ] }, { "id": "DS.d390.s0.e1", "type": "protein", "text": [ "Peptide YY(3-36)" ], "offsets": [ [ 29, 45 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P10082" }, { "db_name": "UniProt", "db_id": "P68004" }, { "db_name": "UniProt", "db_id": "Q9TR93" } ] }, { "id": "DS.d390.s0.e2", "type": "protein", "text": [ "glucagon-like peptide-1" ], "offsets": [ [ 47, 70 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O12956" }, { "db_name": "UniProt", "db_id": "P01272" }, { "db_name": "UniProt", "db_id": "P01273" }, { "db_name": "UniProt", "db_id": "P01274" }, { "db_name": "UniProt", "db_id": "P01275" }, { "db_name": "UniProt", "db_id": "P01278" }, { "db_name": "UniProt", "db_id": "P05110" }, { "db_name": "UniProt", "db_id": "P06883" }, { "db_name": "UniProt", "db_id": "P15438" }, { "db_name": "UniProt", "db_id": "P22890" }, { "db_name": "UniProt", "db_id": "P29794" }, { "db_name": "UniProt", "db_id": "P55095" }, { "db_name": "UniProt", "db_id": "P68259" }, { "db_name": "UniProt", "db_id": "Q8MJ25" } ] }, { "id": "DS.d390.s0.e3", "type": "protein", "text": [ "GLP-1" ], "offsets": [ [ 72, 77 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O12956" }, { "db_name": "UniProt", "db_id": "P01272" }, { "db_name": "UniProt", "db_id": "P01273" }, { "db_name": "UniProt", "db_id": "P01274" }, { "db_name": "UniProt", "db_id": "P01275" }, { "db_name": "UniProt", "db_id": "P05110" }, { "db_name": "UniProt", "db_id": "P06883" }, { "db_name": "UniProt", "db_id": "P22890" }, { "db_name": "UniProt", "db_id": "P29794" }, { "db_name": "UniProt", "db_id": "P55095" }, { "db_name": "UniProt", "db_id": "P68259" }, { "db_name": "UniProt", "db_id": "Q06605" }, { "db_name": "UniProt", "db_id": "Q8MJ25" } ] }, { "id": "DS.d390.s0.e4", "type": "protein", "text": [ "leptin" ], "offsets": [ [ 80, 86 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O02750" }, { "db_name": "UniProt", "db_id": "O93416" }, { "db_name": "UniProt", "db_id": "Q28603" }, { "db_name": "UniProt", "db_id": "Q95189" }, { "db_name": "UniProt", "db_id": "Q95234" } ] }, { "id": "DS.d390.s0.e5", "type": "protein", "text": [ "ghrelin" ], "offsets": [ [ 88, 95 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q6BEG6" }, { "db_name": "UniProt", "db_id": "Q6BEG7" }, { "db_name": "UniProt", "db_id": "Q9BDJ6" }, { "db_name": "UniProt", "db_id": "Q9BEF8" }, { "db_name": "UniProt", "db_id": "Q9EQX0" }, { "db_name": "UniProt", "db_id": "Q9GKY5" }, { "db_name": "UniProt", "db_id": "Q9QYH7" }, { "db_name": "UniProt", "db_id": "Q9UBU3" } ] }, { "id": "DS.d390.s0.e6", "type": "protein", "text": [ "insulin" ], "offsets": [ [ 97, 104 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01314" }, { "db_name": "UniProt", "db_id": "P01316" }, { "db_name": "UniProt", "db_id": "P01319" }, { "db_name": "UniProt", "db_id": "P01320" }, { "db_name": "UniProt", "db_id": "P01324" }, { "db_name": "UniProt", "db_id": "P01328" }, { "db_name": "UniProt", "db_id": "P01330" }, { "db_name": "UniProt", "db_id": "P01331" }, { "db_name": "UniProt", "db_id": "P01334" }, { "db_name": "UniProt", "db_id": "P01336" }, { "db_name": "UniProt", "db_id": "P01340" }, { "db_name": "UniProt", "db_id": "P07453" }, { "db_name": "UniProt", "db_id": "P09476" }, { "db_name": "UniProt", "db_id": "P09477" }, { "db_name": "UniProt", "db_id": "P0C236" }, { "db_name": "UniProt", "db_id": "P12703" }, { "db_name": "UniProt", "db_id": "P12704" }, { "db_name": "UniProt", "db_id": "P12708" }, { "db_name": "UniProt", "db_id": "P13190" }, { "db_name": "UniProt", "db_id": "P18109" }, { "db_name": "UniProt", "db_id": "P29335" }, { "db_name": "UniProt", "db_id": "P42633" }, { "db_name": "UniProt", "db_id": "P67968" }, { "db_name": "UniProt", "db_id": "P67969" }, { "db_name": "UniProt", "db_id": "P67971" }, { "db_name": "UniProt", "db_id": "P67973" }, { "db_name": "UniProt", "db_id": "P67974" }, { "db_name": "UniProt", "db_id": "P68243" }, { "db_name": "UniProt", "db_id": "P68245" }, { "db_name": "UniProt", "db_id": "P68987" }, { "db_name": "UniProt", "db_id": "P68988" }, { "db_name": "UniProt", "db_id": "P68989" }, { "db_name": "UniProt", "db_id": "P68990" }, { "db_name": "UniProt", "db_id": "P68991" }, { "db_name": "UniProt", "db_id": "P68992" }, { "db_name": "UniProt", "db_id": "P69046" }, { "db_name": "UniProt", "db_id": "P69047" }, { "db_name": "UniProt", "db_id": "P69048" }, { "db_name": "UniProt", "db_id": "P81423" }, { "db_name": "UniProt", "db_id": "P81881" }, { "db_name": "UniProt", "db_id": "Q9TQY7" } ] } ]
[]
[]
[]
DS.d392
18584285
[ { "id": "DS.d392.s0", "type": "", "text": [ "Transglutaminases catalyze a calcium-dependent transamidation reaction that produces covalent cross-linking of available substrate glutamine residues and modifies the extracellular matrix." ], "offsets": [ [ 0, 188 ] ] } ]
[ { "id": "DS.d392.s0.e0", "type": "protein", "text": [ "Transglutaminases" ], "offsets": [ [ 0, 17 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P40746" }, { "db_name": "UniProt", "db_id": "P52183" }, { "db_name": "UniProt", "db_id": "P81453" }, { "db_name": "UniProt", "db_id": "Q819L3" }, { "db_name": "UniProt", "db_id": "Q81MS1" }, { "db_name": "UniProt", "db_id": "Q8GR90" }, { "db_name": "UniProt", "db_id": "Q9K5W7" } ] }, { "id": "DS.d392.s0.e1", "type": "compound", "text": [ "glutamine" ], "offsets": [ [ 131, 140 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "738" }, { "db_name": "PubChem", "db_id": "5961" } ] } ]
[]
[]
[ { "id": "DS.d392.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d392.s0.e1", "arg2_id": "DS.d392.s0.e0", "normalized": [] } ]
DS.d393
18584286
[ { "id": "DS.d393.s0", "type": "", "text": [ "We fed rats lysine or valine deficient diet for 4 weeks and examined the mRNA expressions of serine synthesising (3-phosphoglycerate dehydrogenase, PHGDH) and serine/threonine degrading enzymes (serine dehydratase, SDS) in the liver." ], "offsets": [ [ 0, 233 ] ] }, { "id": "DS.d393.s1", "type": "", "text": [ "Dietary deficiency induced marked elevation of hepatic serine and threonine levels associated with enhancement of PHGDH mRNA expression and repression of SDS mRNA expression." ], "offsets": [ [ 234, 408 ] ] } ]
[ { "id": "DS.d393.s0.e0", "type": "compound", "text": [ "lysine" ], "offsets": [ [ 12, 18 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "866" }, { "db_name": "PubChem", "db_id": "5962" } ] }, { "id": "DS.d393.s0.e1", "type": "compound", "text": [ "valine" ], "offsets": [ [ 22, 28 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6287" } ] }, { "id": "DS.d393.s0.e2", "type": "protein", "text": [ "PHGDH" ], "offsets": [ [ 148, 153 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O43175" }, { "db_name": "UniProt", "db_id": "Q5EAD2" }, { "db_name": "UniProt", "db_id": "Q5R7M2" }, { "db_name": "UniProt", "db_id": "Q60HD7" } ] }, { "id": "DS.d393.s0.e3", "type": "protein", "text": [ "SDS" ], "offsets": [ [ 215, 218 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P20132" } ] }, { "id": "DS.d393.s1.e0", "type": "compound", "text": [ "serine" ], "offsets": [ [ 289, 295 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5951" } ] }, { "id": "DS.d393.s1.e1", "type": "compound", "text": [ "threonine" ], "offsets": [ [ 300, 309 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6288" } ] }, { "id": "DS.d393.s1.e2", "type": "protein", "text": [ "PHGDH" ], "offsets": [ [ 348, 353 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O43175" }, { "db_name": "UniProt", "db_id": "Q5EAD2" }, { "db_name": "UniProt", "db_id": "Q5R7M2" }, { "db_name": "UniProt", "db_id": "Q60HD7" } ] }, { "id": "DS.d393.s1.e3", "type": "protein", "text": [ "SDS" ], "offsets": [ [ 388, 391 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P20132" } ] } ]
[]
[]
[]
DS.d394
18584306
[ { "id": "DS.d394.s0", "type": "", "text": [ "Site-directed mutation test and mithramycin A treatment demonstrated that the ZNF230 promoter contained a functional Sp1 site." ], "offsets": [ [ 0, 126 ] ] } ]
[ { "id": "DS.d394.s0.e0", "type": "compound", "text": [ "mithramycin A" ], "offsets": [ [ 32, 45 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "29051" }, { "db_name": "PubChem", "db_id": "163659" }, { "db_name": "PubChem", "db_id": "230076" }, { "db_name": "PubChem", "db_id": "6326719" } ] }, { "id": "DS.d394.s0.e1", "type": "protein", "text": [ "ZNF230" ], "offsets": [ [ 78, 84 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q8WVD5" }, { "db_name": "UniProt", "db_id": "Q9UIE0" } ] }, { "id": "DS.d394.s0.e2", "type": "protein", "text": [ "Sp1" ], "offsets": [ [ 117, 120 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O14300" }, { "db_name": "UniProt", "db_id": "O89090" }, { "db_name": "UniProt", "db_id": "P17379" }, { "db_name": "UniProt", "db_id": "Q01714" }, { "db_name": "UniProt", "db_id": "Q85439" }, { "db_name": "UniProt", "db_id": "Q85449" }, { "db_name": "UniProt", "db_id": "Q85451" } ] } ]
[]
[]
[ { "id": "DS.d394.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d394.s0.e0", "arg2_id": "DS.d394.s0.e2", "normalized": [] }, { "id": "DS.d394.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d394.s0.e0", "arg2_id": "DS.d394.s0.e1", "normalized": [] } ]
DS.d395
18584320
[ { "id": "DS.d395.s0", "type": "", "text": [ "Progesterone effects on neuronal ultrastructure and expression of microtubule-associated protein 2 (MAP2) in rats with acute spinal cord injury." ], "offsets": [ [ 0, 144 ] ] }, { "id": "DS.d395.s1", "type": "", "text": [ "(4) Our data indicated that progesterone maintained in part neuronal ultrastructure, attenuated chromatolysis, and preclude the loss of MAP2, suggesting a protective effect during the early phases of spinal cord injury." ], "offsets": [ [ 145, 364 ] ] } ]
[ { "id": "DS.d395.s0.e0", "type": "compound", "text": [ "Progesterone" ], "offsets": [ [ 0, 12 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5994" } ] }, { "id": "DS.d395.s0.e1", "type": "protein", "text": [ "microtubule-associated protein 2" ], "offsets": [ [ 66, 98 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P11137" }, { "db_name": "UniProt", "db_id": "P15146" }, { "db_name": "UniProt", "db_id": "P20357" } ] }, { "id": "DS.d395.s0.e2", "type": "protein", "text": [ "MAP2" ], "offsets": [ [ 100, 104 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P11137" }, { "db_name": "UniProt", "db_id": "P38174" }, { "db_name": "UniProt", "db_id": "Q5Z859" }, { "db_name": "UniProt", "db_id": "Q6XMH6" }, { "db_name": "UniProt", "db_id": "Q6XMH7" }, { "db_name": "UniProt", "db_id": "Q8SR45" } ] }, { "id": "DS.d395.s1.e0", "type": "compound", "text": [ "progesterone" ], "offsets": [ [ 173, 185 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5994" } ] }, { "id": "DS.d395.s1.e1", "type": "protein", "text": [ "MAP2" ], "offsets": [ [ 281, 285 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P11137" }, { "db_name": "UniProt", "db_id": "P38174" }, { "db_name": "UniProt", "db_id": "Q5Z859" }, { "db_name": "UniProt", "db_id": "Q6XMH6" }, { "db_name": "UniProt", "db_id": "Q6XMH7" }, { "db_name": "UniProt", "db_id": "Q8SR45" } ] } ]
[]
[]
[ { "id": "DS.d395.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d395.s0.e0", "arg2_id": "DS.d395.s0.e1", "normalized": [] }, { "id": "DS.d395.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d395.s0.e0", "arg2_id": "DS.d395.s0.e2", "normalized": [] }, { "id": "DS.d395.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d395.s1.e0", "arg2_id": "DS.d395.s1.e1", "normalized": [] } ]
DS.d396
18584336
[ { "id": "DS.d396.s0", "type": "", "text": [ "In conclusion, our results indicate that chronic THC modulates the expression and subcellular localization of proteins implicated in Ras signaling, calcium-buffering potential, and trafficking." ], "offsets": [ [ 0, 193 ] ] } ]
[ { "id": "DS.d396.s0.e0", "type": "compound", "text": [ "THC" ], "offsets": [ [ 49, 52 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "16078" }, { "db_name": "PubChem", "db_id": "134740" } ] }, { "id": "DS.d396.s0.e1", "type": "protein", "text": [ "Ras" ], "offsets": [ [ 133, 136 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P03967" }, { "db_name": "UniProt", "db_id": "P22126" }, { "db_name": "UniProt", "db_id": "Q07152" } ] } ]
[]
[]
[ { "id": "DS.d396.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d396.s0.e0", "arg2_id": "DS.d396.s0.e1", "normalized": [] } ]
DS.d397
18584896
[ { "id": "DS.d397.s0", "type": "", "text": [ "For this purpose, on day 0, male Wistar rats received NTG (120 microg/kg, iv) with or without pre-administration of PKC inhibitor chelerythrine (CHE), capsaicin (CAP) to deplete CGRP from sensory nerves or mK(ATP) channel blocker 5-hydroxydecaonic acid (5HD)." ], "offsets": [ [ 0, 259 ] ] } ]
[ { "id": "DS.d397.s0.e0", "type": "compound", "text": [ "chelerythrine" ], "offsets": [ [ 130, 143 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2703" }, { "db_name": "PubChem", "db_id": "411938" } ] }, { "id": "DS.d397.s0.e1", "type": "compound", "text": [ "capsaicin" ], "offsets": [ [ 151, 160 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1548943" } ] }, { "id": "DS.d397.s0.e2", "type": "protein", "text": [ "CGRP" ], "offsets": [ [ 178, 182 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P10286" }, { "db_name": "UniProt", "db_id": "P30880" }, { "db_name": "UniProt", "db_id": "P30881" }, { "db_name": "UniProt", "db_id": "P31888" }, { "db_name": "UniProt", "db_id": "P80511" } ] }, { "id": "DS.d397.s0.e3", "type": "compound", "text": [ "5HD" ], "offsets": [ [ 254, 257 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "25058136" } ] } ]
[]
[]
[ { "id": "DS.d397.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d397.s0.e1", "arg2_id": "DS.d397.s0.e2", "normalized": [] } ]
DS.d398
18585399
[ { "id": "DS.d398.s0", "type": "", "text": [ "The anti-convulsant stiripentol acts directly on the GABA(A) receptor as a positive allosteric modulator." ], "offsets": [ [ 0, 105 ] ] } ]
[ { "id": "DS.d398.s0.e0", "type": "compound", "text": [ "stiripentol" ], "offsets": [ [ 20, 31 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5311454" } ] }, { "id": "DS.d398.s0.e1", "type": "protein", "text": [ "GABA(A) receptor" ], "offsets": [ [ 53, 69 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P26714" }, { "db_name": "UniProt", "db_id": "Q08832" }, { "db_name": "UniProt", "db_id": "Q9BLY8" } ] } ]
[]
[]
[ { "id": "DS.d398.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d398.s0.e0", "arg2_id": "DS.d398.s0.e1", "normalized": [] } ]
DS.d399
18585720
[ { "id": "DS.d399.s0", "type": "", "text": [ "Di-oleoyl phosphatidylcholine (PC-18:1) stimulates paraoxonase 1 (PON1) enzymatic and biological activities: in vitro and in vivo studies." ], "offsets": [ [ 0, 138 ] ] } ]
[ { "id": "DS.d399.s0.e0", "type": "compound", "text": [ "oleoyl" ], "offsets": [ [ 3, 9 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5885531" } ] }, { "id": "DS.d399.s0.e1", "type": "protein", "text": [ "PON1" ], "offsets": [ [ 66, 70 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P27169" }, { "db_name": "UniProt", "db_id": "P27170" } ] } ]
[]
[]
[ { "id": "DS.d399.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d399.s0.e0", "arg2_id": "DS.d399.s0.e1", "normalized": [] } ]
DS.d400
18585721
[ { "id": "DS.d400.s0", "type": "", "text": [ "With the exception of specific genetic defects in purine metabolism, increased uric acid is generally associated with important risk factors for atherosclerosis like hypertension, abdominal obesity, insulin resistance, the metabolic syndrome and renal failure." ], "offsets": [ [ 0, 260 ] ] } ]
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[]
[]
[ { "id": "DS.d400.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d400.s0.e1", "arg2_id": "DS.d400.s0.e2", "normalized": [] } ]
DS.d401
18585744
[ { "id": "DS.d401.s0", "type": "", "text": [ "The distribution of sugar moieties within the epididymal region of the Sudani duck was investigated using ten different fluorescein isothiocyanate (FITC) conjugated lectins." ], "offsets": [ [ 0, 173 ] ] } ]
[ { "id": "DS.d401.s0.e0", "type": "compound", "text": [ "fluorescein isothiocyanate" ], "offsets": [ [ 120, 146 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "18730" } ] }, { "id": "DS.d401.s0.e1", "type": "compound", "text": [ "FITC" ], "offsets": [ [ 148, 152 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "18730" } ] }, { "id": "DS.d401.s0.e2", "type": "protein", "text": [ "lectins" ], "offsets": [ [ 165, 172 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P02871" }, { "db_name": "UniProt", "db_id": "P02873" }, { "db_name": "UniProt", "db_id": "P02874" }, { "db_name": "UniProt", "db_id": "P02875" }, { "db_name": "UniProt", "db_id": "P07386" }, { "db_name": "UniProt", "db_id": "P16108" }, { "db_name": "UniProt", "db_id": "P16349" }, { "db_name": "UniProt", "db_id": "P16351" }, { "db_name": "UniProt", "db_id": "P16352" }, { "db_name": "UniProt", "db_id": "P33888" }, { "db_name": "UniProt", "db_id": "P38662" }, { "db_name": "UniProt", "db_id": "P42088" }, { "db_name": "UniProt", "db_id": "P83410" }, { "db_name": "UniProt", "db_id": "P83511" }, { "db_name": "UniProt", "db_id": "P84987" }, { "db_name": "UniProt", "db_id": "Q41114" } ] } ]
[]
[]
[]
DS.d402
18586252
[ { "id": "DS.d402.s0", "type": "", "text": [ "High glucose and interferon gamma synergistically stimulate MMP-1 expression in U937 macrophages by increasing transcription factor STAT1 activity." ], "offsets": [ [ 0, 147 ] ] }, { "id": "DS.d402.s1", "type": "", "text": [ "To test our hypothesis that hyperglycemia interplays with interferon gamma (IFN gamma), a key factor involved in atherosclerosis, to up-regulate the expression of genes such as matrix metalloproteinases (MMPs) and cytokines that are involved in plaque destabilization, U937 macrophages cultured in medium containing either normal or high glucose were challenged with IFN gamma and the expression of MMPs and cytokines were then quantified by real-time polymerase chain reaction (PCR) and enzyme-linked immunosorbent assay (ELISA)." ], "offsets": [ [ 148, 678 ] ] }, { "id": "DS.d402.s2", "type": "", "text": [ "Results showed that high glucose and IFN gamma had a synergistic effect on the expression of MMP-1, MMP-9 and IL-1 beta." ], "offsets": [ [ 679, 799 ] ] }, { "id": "DS.d402.s3", "type": "", "text": [ "Furthermore, high glucose and IFN gamma exert the synergistic effect on MMP-1 expression by enhancing STAT1 phosphorylation and STAT1 transcriptional activity." ], "offsets": [ [ 800, 959 ] ] } ]
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"db_name": "UniProt", "db_id": "P42224" }, { "db_name": "UniProt", "db_id": "Q764M5" } ] }, { "id": "DS.d402.s1.e0", "type": "protein", "text": [ "interferon gamma" ], "offsets": [ [ 206, 222 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q9TTB0" } ] }, { "id": "DS.d402.s1.e1", "type": "protein", "text": [ "IFN gamma" ], "offsets": [ [ 224, 233 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O35497" }, { "db_name": "UniProt", "db_id": "O35735" }, { "db_name": "UniProt", "db_id": "O57571" }, { "db_name": "UniProt", "db_id": "O57603" }, { "db_name": "UniProt", "db_id": "O57608" }, { "db_name": "UniProt", "db_id": "O73915" }, { "db_name": "UniProt", "db_id": "O77763" }, { "db_name": "UniProt", "db_id": "P01579" }, { "db_name": "UniProt", "db_id": "P01580" }, { "db_name": "UniProt", "db_id": "P01581" }, { "db_name": "UniProt", "db_id": "P07353" }, { "db_name": "UniProt", "db_id": "P17773" }, { "db_name": "UniProt", "db_id": "P17803" }, { "db_name": "UniProt", "db_id": 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"db_name": "PubChem", "db_id": "79025" } ] }, { "id": "DS.d402.s2.e1", "type": "protein", "text": [ "IFN gamma" ], "offsets": [ [ 716, 725 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O35497" }, { "db_name": "UniProt", "db_id": "O35735" }, { "db_name": "UniProt", "db_id": "O57571" }, { "db_name": "UniProt", "db_id": "O57603" }, { "db_name": "UniProt", "db_id": "O57608" }, { "db_name": "UniProt", "db_id": "O73915" }, { "db_name": "UniProt", "db_id": "O77763" }, { "db_name": "UniProt", "db_id": "P01579" }, { "db_name": "UniProt", "db_id": "P01580" }, { "db_name": "UniProt", "db_id": "P01581" }, { "db_name": "UniProt", "db_id": "P07353" }, { "db_name": "UniProt", "db_id": "P17773" }, { "db_name": "UniProt", "db_id": "P17803" }, { "db_name": "UniProt", "db_id": "P28333" }, { "db_name": "UniProt", "db_id": "P28341" }, { "db_name": "UniProt", "db_id": "P30123" }, { "db_name": "UniProt", "db_id": "P42160" }, { "db_name": "UniProt", "db_id": "P42161" }, { "db_name": "UniProt", "db_id": "P42162" }, { "db_name": "UniProt", "db_id": "P46402" }, { "db_name": "UniProt", "db_id": "P49708" }, { "db_name": "UniProt", "db_id": "P63309" }, { "db_name": "UniProt", "db_id": "P63310" }, { "db_name": "UniProt", "db_id": "P63311" }, { "db_name": "UniProt", "db_id": "P79154" }, { "db_name": "UniProt", "db_id": "Q1WM28" }, { "db_name": "UniProt", "db_id": "Q25BC0" }, { "db_name": "UniProt", "db_id": "Q2PE75" }, { "db_name": "UniProt", "db_id": "Q4ZH68" }, { "db_name": "UniProt", "db_id": "Q5CCK0" }, { "db_name": "UniProt", "db_id": "Q5I6S9" }, { "db_name": "UniProt", "db_id": "Q62574" }, { "db_name": "UniProt", "db_id": "Q647G2" }, { "db_name": "UniProt", "db_id": "Q7TSP4" }, { "db_name": "UniProt", "db_id": "Q865W6" }, { "db_name": "UniProt", "db_id": "Q865X1" }, { "db_name": "UniProt", "db_id": "Q865Y4" }, { "db_name": "UniProt", "db_id": "Q866Y6" }, { "db_name": "UniProt", "db_id": "Q8MKF5" }, { "db_name": "UniProt", "db_id": "Q8SPW9" }, { "db_name": "UniProt", "db_id": "Q9QXX2" }, { "db_name": "UniProt", "db_id": "Q9TTB0" }, { "db_name": "UniProt", "db_id": "Q9TV67" }, { "db_name": "UniProt", "db_id": "Q9YGB9" } ] }, { "id": "DS.d402.s2.e2", "type": "protein", "text": [ "MMP-1" ], "offsets": [ [ 772, 777 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P03956" }, { "db_name": "UniProt", "db_id": "P13943" }, { "db_name": "UniProt", "db_id": "P21692" }, { "db_name": "UniProt", "db_id": "P28053" }, { "db_name": "UniProt", "db_id": "P81563" }, { "db_name": "UniProt", "db_id": "Q11133" }, { "db_name": "UniProt", "db_id": "Q9XSZ5" } ] }, { "id": "DS.d402.s2.e3", "type": "protein", "text": [ "MMP-9" ], "offsets": [ [ 779, 784 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O18733" }, { "db_name": "UniProt", "db_id": "P14780" }, { "db_name": "UniProt", "db_id": "P41245" }, { "db_name": "UniProt", "db_id": "P41246" }, { "db_name": "UniProt", "db_id": "P50282" }, { "db_name": "UniProt", "db_id": "P52176" } ] }, { "id": "DS.d402.s2.e4", "type": "protein", "text": [ "IL-1 beta" ], "offsets": [ [ 789, 798 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01584" }, { "db_name": "UniProt", "db_id": "P09428" }, { "db_name": "UniProt", "db_id": "P10749" }, { "db_name": "UniProt", "db_id": "P14628" }, { "db_name": "UniProt", "db_id": "P21621" }, { "db_name": "UniProt", "db_id": "P26889" }, { "db_name": "UniProt", "db_id": "P41687" }, { "db_name": "UniProt", "db_id": "P46648" }, { "db_name": "UniProt", "db_id": "P48090" }, { "db_name": "UniProt", "db_id": "P51493" }, { "db_name": "UniProt", "db_id": "P51745" }, { "db_name": "UniProt", "db_id": "P79162" }, { "db_name": "UniProt", "db_id": "P79182" }, { "db_name": "UniProt", "db_id": "Q28292" }, { "db_name": "UniProt", "db_id": "Q28386" }, { "db_name": "UniProt", "db_id": "Q2HZH0" }, { "db_name": "UniProt", "db_id": "Q2MH07" }, { "db_name": "UniProt", "db_id": "Q63264" }, { "db_name": "UniProt", "db_id": "Q6PUD2" }, { "db_name": "UniProt", "db_id": "Q6R2X3" }, { "db_name": "UniProt", "db_id": "Q865X8" }, { "db_name": "UniProt", "db_id": "Q8WNR2" }, { "db_name": "UniProt", "db_id": "Q9WVG1" }, { "db_name": "UniProt", "db_id": "Q9XS77" } ] }, { "id": "DS.d402.s3.e0", "type": "compound", "text": [ "glucose" ], "offsets": [ [ 818, 825 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "206" }, { "db_name": "PubChem", "db_id": "5793" }, { "db_name": "PubChem", "db_id": "64689" }, { "db_name": "PubChem", "db_id": "79025" } ] }, { "id": "DS.d402.s3.e1", "type": "protein", "text": [ "IFN gamma" ], "offsets": [ [ 830, 839 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O35497" }, { "db_name": "UniProt", "db_id": "O35735" }, { "db_name": "UniProt", "db_id": "O57571" }, { "db_name": "UniProt", "db_id": "O57603" }, { "db_name": "UniProt", "db_id": "O57608" }, { "db_name": "UniProt", "db_id": "O73915" }, { "db_name": "UniProt", "db_id": "O77763" }, { "db_name": "UniProt", "db_id": "P01579" }, { "db_name": "UniProt", "db_id": "P01580" }, { "db_name": "UniProt", "db_id": "P01581" }, { "db_name": "UniProt", "db_id": "P07353" }, { "db_name": "UniProt", "db_id": "P17773" }, { "db_name": "UniProt", "db_id": "P17803" }, { "db_name": "UniProt", "db_id": "P28333" }, { "db_name": "UniProt", "db_id": "P28341" }, { "db_name": "UniProt", "db_id": "P30123" }, { "db_name": "UniProt", "db_id": "P42160" }, { "db_name": "UniProt", "db_id": "P42161" }, { "db_name": "UniProt", "db_id": "P42162" }, { "db_name": "UniProt", "db_id": "P46402" }, { "db_name": "UniProt", "db_id": "P49708" }, { "db_name": "UniProt", "db_id": "P63309" }, { "db_name": "UniProt", "db_id": "P63310" }, { "db_name": "UniProt", "db_id": "P63311" }, { "db_name": "UniProt", "db_id": "P79154" }, { "db_name": "UniProt", "db_id": "Q1WM28" }, { "db_name": "UniProt", "db_id": "Q25BC0" }, { "db_name": "UniProt", "db_id": "Q2PE75" }, { "db_name": "UniProt", "db_id": "Q4ZH68" }, { "db_name": "UniProt", "db_id": "Q5CCK0" }, { "db_name": "UniProt", "db_id": "Q5I6S9" }, { "db_name": "UniProt", "db_id": "Q62574" }, { "db_name": "UniProt", "db_id": "Q647G2" }, { "db_name": "UniProt", "db_id": "Q7TSP4" }, { "db_name": "UniProt", "db_id": "Q865W6" }, { "db_name": "UniProt", "db_id": "Q865X1" }, { "db_name": "UniProt", "db_id": "Q865Y4" }, { "db_name": "UniProt", "db_id": "Q866Y6" }, { "db_name": "UniProt", "db_id": "Q8MKF5" }, { "db_name": "UniProt", "db_id": "Q8SPW9" }, { "db_name": "UniProt", "db_id": "Q9QXX2" }, { "db_name": "UniProt", "db_id": "Q9TTB0" }, { "db_name": "UniProt", "db_id": "Q9TV67" }, { "db_name": "UniProt", "db_id": "Q9YGB9" } ] }, { "id": "DS.d402.s3.e2", "type": "protein", "text": [ "MMP-1" ], "offsets": [ [ 872, 877 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P03956" }, { "db_name": "UniProt", "db_id": "P13943" }, { "db_name": "UniProt", "db_id": "P21692" }, { "db_name": "UniProt", "db_id": "P28053" }, { "db_name": "UniProt", "db_id": "P81563" }, { "db_name": "UniProt", "db_id": "Q11133" }, { "db_name": "UniProt", "db_id": "Q9XSZ5" } ] }, { "id": "DS.d402.s3.e3", "type": "protein", "text": [ "STAT1" ], "offsets": [ [ 902, 907 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P42224" }, { "db_name": "UniProt", "db_id": "Q764M5" } ] }, { "id": "DS.d402.s3.e4", "type": "protein", "text": [ "STAT1" ], "offsets": [ [ 928, 933 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P42224" }, { "db_name": "UniProt", "db_id": "Q764M5" } ] } ]
[]
[]
[ { "id": "DS.d402.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d402.s0.e0", "arg2_id": "DS.d402.s0.e3", "normalized": [] }, { "id": "DS.d402.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d402.s0.e0", "arg2_id": "DS.d402.s0.e2", "normalized": [] }, { "id": "DS.d402.s2.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d402.s2.e0", "arg2_id": "DS.d402.s2.e4", "normalized": [] }, { "id": "DS.d402.s2.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d402.s2.e0", "arg2_id": "DS.d402.s2.e2", "normalized": [] }, { "id": "DS.d402.s2.i3", "type": "compound-protein-interaction", "arg1_id": "DS.d402.s2.e0", "arg2_id": "DS.d402.s2.e3", "normalized": [] }, { "id": "DS.d402.s3.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d402.s3.e0", "arg2_id": "DS.d402.s3.e3", "normalized": [] }, { "id": "DS.d402.s3.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d402.s3.e0", "arg2_id": "DS.d402.s3.e2", "normalized": [] } ]
DS.d403
18586420
[ { "id": "DS.d403.s0", "type": "", "text": [ "In Experiment 2, lactoferrin (10 mg/mL) combined with cidofovir (62.5 microg/mL) inhibited up to 100,200 PFU/mL of virus in cell culture." ], "offsets": [ [ 0, 137 ] ] } ]
[ { "id": "DS.d403.s0.e0", "type": "protein", "text": [ "lactoferrin" ], "offsets": [ [ 17, 28 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O77698" }, { "db_name": "UniProt", "db_id": "O77811" }, { "db_name": "UniProt", "db_id": "P02788" }, { "db_name": "UniProt", "db_id": "P08071" }, { "db_name": "UniProt", "db_id": "P14632" }, { "db_name": "UniProt", "db_id": "P24627" }, { "db_name": "UniProt", "db_id": "Q29477" }, { "db_name": "UniProt", "db_id": "Q9TUM0" } ] }, { "id": "DS.d403.s0.e1", "type": "compound", "text": [ "cidofovir" ], "offsets": [ [ 54, 63 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "60613" } ] } ]
[]
[]
[]
DS.d404
18586549
[ { "id": "DS.d404.s0", "type": "", "text": [ "We systematically investigated whether PD-related stresses including MG132 and epoxomicin (proteasomal impairment), tunicamycin (unfolded protein stress), and rotenone (mitochondrial dysfunction) resulted in expressional changes of parkin and other E3 ubiquitin ligases (dorfin, SIAH-1)." ], "offsets": [ [ 0, 287 ] ] } ]
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[]
[]
[]
DS.d405
18587580
[ { "id": "DS.d405.s0", "type": "", "text": [ "CDDO-Me, a synthetic triterpenoid, inhibits expression of IL-6 and Stat3 phosphorylation in multi-drug resistant ovarian cancer cells." ], "offsets": [ [ 0, 134 ] ] }, { "id": "DS.d405.s1", "type": "", "text": [ "To explore potential therapeutic strategies for interrupting signaling through this pathway, we assessed the ability of CDDO-Me, a synthetic triterpenoid, to inhibit IL-6 secretion, Stat3 phosphorylation, Stat3 nuclear translocation and paclitaxel sensitivity in several cell line model systems." ], "offsets": [ [ 135, 430 ] ] }, { "id": "DS.d405.s2", "type": "", "text": [ "These studies demonstrated that CDDO-Me significantly inhibits IL-6 secretion in paclitaxel-resistant ovarian cancer cells and specifically suppresses IL-6-or oncostatin M-induced Stat3 nuclear translocation." ], "offsets": [ [ 431, 639 ] ] }, { "id": "DS.d405.s3", "type": "", "text": [ "Treatment with CDDO-Me significantly decreases the levels of Stat3, Jak2, and Src phosphorylation in ovarian and breast cancer cell lines with constitutively activated Stat3." ], "offsets": [ [ 640, 814 ] ] }, { "id": "DS.d405.s4", "type": "", "text": [ "Our data confirm that CDDO-Me interrupts the signaling of multiple kinases involved in the IL-6-Stat3 and Src signaling pathways." ], "offsets": [ [ 815, 944 ] ] } ]
[ { "id": "DS.d405.s0.e0", "type": "compound", "text": [ "CDDO-Me" ], "offsets": [ [ 0, 7 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "400769" } ] }, { "id": "DS.d405.s0.e1", "type": "protein", "text": [ "IL-6" ], "offsets": [ [ 58, 62 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O35736" }, { "db_name": "UniProt", "db_id": "P05231" }, { "db_name": "UniProt", "db_id": "P08505" }, { "db_name": "UniProt", "db_id": "P20607" }, { "db_name": "UniProt", "db_id": "P26892" }, { "db_name": "UniProt", "db_id": "P26893" }, { "db_name": "UniProt", "db_id": "P29455" }, { "db_name": "UniProt", "db_id": "P41323" }, { "db_name": "UniProt", "db_id": "P41683" }, { "db_name": "UniProt", "db_id": "P41693" }, { "db_name": "UniProt", "db_id": "P46650" }, { "db_name": "UniProt", "db_id": "P51494" }, { "db_name": "UniProt", "db_id": "P79341" }, { "db_name": "UniProt", "db_id": "Q25BC2" }, { "db_name": "UniProt", "db_id": "Q28319" }, { "db_name": "UniProt", "db_id": "Q28747" }, { "db_name": "UniProt", "db_id": "Q28819" }, { "db_name": "UniProt", "db_id": "Q2MH06" }, { "db_name": "UniProt", "db_id": "Q5I6E3" }, { "db_name": "UniProt", "db_id": "Q6V919" }, { "db_name": "UniProt", "db_id": "Q865W7" }, { "db_name": "UniProt", "db_id": "Q865X6" }, { "db_name": "UniProt", "db_id": "Q8MKH0" }, { "db_name": "UniProt", "db_id": "Q95181" }, { "db_name": "UniProt", "db_id": "Q9MZR1" }, { "db_name": "UniProt", "db_id": "Q9XT80" } ] }, { "id": "DS.d405.s0.e2", "type": "protein", "text": [ "Stat3" ], "offsets": [ [ 67, 72 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P42227" }, { "db_name": "UniProt", "db_id": "P52631" } ] }, { "id": "DS.d405.s1.e0", "type": "compound", "text": [ "CDDO-Me" ], "offsets": [ [ 255, 262 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "400769" } ] }, { "id": "DS.d405.s1.e1", "type": "protein", "text": [ "IL-6" ], "offsets": [ [ 301, 305 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O35736" }, { "db_name": "UniProt", "db_id": "P05231" }, { "db_name": "UniProt", "db_id": "P08505" }, { "db_name": "UniProt", "db_id": "P20607" }, { "db_name": "UniProt", "db_id": "P26892" }, { "db_name": "UniProt", "db_id": "P26893" }, { "db_name": "UniProt", "db_id": "P29455" }, { "db_name": "UniProt", "db_id": "P41323" }, { "db_name": "UniProt", "db_id": "P41683" }, { "db_name": "UniProt", "db_id": "P41693" }, { "db_name": "UniProt", "db_id": "P46650" }, { "db_name": "UniProt", "db_id": "P51494" }, { "db_name": "UniProt", "db_id": "P79341" }, { "db_name": "UniProt", "db_id": "Q25BC2" }, { "db_name": "UniProt", "db_id": "Q28319" }, { "db_name": "UniProt", "db_id": "Q28747" }, { "db_name": "UniProt", "db_id": "Q28819" }, { "db_name": "UniProt", "db_id": "Q2MH06" }, { "db_name": "UniProt", "db_id": "Q5I6E3" }, { "db_name": "UniProt", "db_id": "Q6V919" }, { "db_name": "UniProt", "db_id": "Q865W7" }, { "db_name": "UniProt", "db_id": "Q865X6" }, { "db_name": "UniProt", "db_id": "Q8MKH0" }, { "db_name": "UniProt", "db_id": "Q95181" }, { "db_name": "UniProt", "db_id": "Q9MZR1" }, { "db_name": "UniProt", "db_id": "Q9XT80" } ] }, { "id": "DS.d405.s1.e2", "type": "protein", "text": [ "Stat3" ], "offsets": [ [ 317, 322 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P42227" }, { "db_name": "UniProt", "db_id": "P52631" } ] }, { "id": "DS.d405.s1.e3", "type": "protein", "text": [ "Stat3" ], "offsets": [ [ 340, 345 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P42227" }, { "db_name": "UniProt", "db_id": "P52631" } ] }, { "id": "DS.d405.s1.e4", "type": "compound", "text": [ "paclitaxel" ], "offsets": [ [ 372, 382 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "4666" }, { "db_name": "PubChem", "db_id": "36314" }, { "db_name": "PubChem", "db_id": "441276" }, { "db_name": "PubChem", "db_id": "5352019" }, { "db_name": "PubChem", "db_id": "6713921" }, { "db_name": "PubChem", "db_id": "6915727" }, { "db_name": "PubChem", "db_id": "44155032" }, { "db_name": "PubChem", "db_id": "53313247" } ] }, { "id": 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DS.d406
18587601
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DS.d407
18587610
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[]
[]