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DS.d408
18587665
[ { "id": "DS.d408.s0", "type": "", "text": [ "Puerarin regulates expressions of VEGF and HIF-1alpha stimulated by STZ." ], "offsets": [ [ 0, 72 ] ] } ]
[ { "id": "DS.d408.s0.e0", "type": "compound", "text": [ "Puerarin" ], "offsets": [ [ 0, 8 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5281807" }, { "db_name": "PubChem", "db_id": "5385074" }, { "db_name": "PubChem", "db_id": "5486172" }, { "db_name": "PubChem", "db_id": "44257207" }, { "db_name": "PubChem", "db_id": "53384442" } ] }, { "id": "DS.d408.s0.e1", "type": "protein", "text": [ "VEGF" ], "offsets": [ [ 34, 38 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P15691" }, { "db_name": "UniProt", "db_id": "P15692" }, { "db_name": "UniProt", "db_id": "P26617" }, { "db_name": "UniProt", "db_id": "P49151" }, { "db_name": "UniProt", "db_id": "P50412" }, { "db_name": "UniProt", "db_id": "P67964" }, { "db_name": "UniProt", "db_id": "P67965" }, { "db_name": "UniProt", "db_id": "Q99PS1" }, { "db_name": "UniProt", "db_id": "Q9GKR0" }, { "db_name": "UniProt", "db_id": "Q9MYV3" } ] }, { "id": "DS.d408.s0.e2", "type": "protein", "text": [ "HIF-1alpha" ], "offsets": [ [ 43, 53 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O35800" }, { "db_name": "UniProt", "db_id": "Q0PGG7" }, { "db_name": "UniProt", "db_id": "Q16665" }, { "db_name": "UniProt", "db_id": "Q309Z6" }, { "db_name": "UniProt", "db_id": "Q61221" }, { "db_name": "UniProt", "db_id": "Q98SW2" }, { "db_name": "UniProt", "db_id": "Q9I8A9" }, { "db_name": "UniProt", "db_id": "Q9XTA5" }, { "db_name": "UniProt", "db_id": "Q9YIB9" } ] } ]
[]
[]
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DS.d409
18588512
[ { "id": "DS.d409.s0", "type": "", "text": [ "In patients with hypertension and diabetes, ARB, ACEi and diuretic treatment increased Ras activation only during the first week." ], "offsets": [ [ 0, 129 ] ] } ]
[ { "id": "DS.d409.s0.e0", "type": "compound", "text": [ "ARB" ], "offsets": [ [ 44, 47 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "439764" } ] }, { "id": "DS.d409.s0.e1", "type": "protein", "text": [ "Ras" ], "offsets": [ [ 87, 90 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P03967" }, { "db_name": "UniProt", "db_id": "P22126" }, { "db_name": "UniProt", "db_id": "Q07152" } ] } ]
[]
[]
[ { "id": "DS.d409.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d409.s0.e0", "arg2_id": "DS.d409.s0.e1", "normalized": [] } ]
DS.d410
18590515
[ { "id": "DS.d410.s0", "type": "", "text": [ "Although the co-expression of alpha2,3-ST and CMP-SAS did not further increase sialylation, an increase in the intracellular pool of CMP-sialic acid was noted." ], "offsets": [ [ 0, 159 ] ] } ]
[ { "id": "DS.d410.s0.e0", "type": "protein", "text": [ "alpha2,3-ST" ], "offsets": [ [ 30, 41 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P54751" }, { "db_name": "UniProt", "db_id": "P61130" }, { "db_name": "UniProt", "db_id": "P61131" }, { "db_name": "UniProt", "db_id": "P72074" }, { "db_name": "UniProt", "db_id": "P72097" }, { "db_name": "UniProt", "db_id": "Q02745" }, { "db_name": "UniProt", "db_id": "Q11200" }, { "db_name": "UniProt", "db_id": "Q11201" }, { "db_name": "UniProt", "db_id": "Q11204" }, { "db_name": "UniProt", "db_id": "Q11205" }, { "db_name": "UniProt", "db_id": "Q11206" }, { "db_name": "UniProt", "db_id": "Q16842" }, { "db_name": "UniProt", "db_id": "Q48211" }, { "db_name": "UniProt", "db_id": "Q6KB58" }, { "db_name": "UniProt", "db_id": "Q6KB59" }, { "db_name": "UniProt", "db_id": "Q91Y74" }, { "db_name": "UniProt", "db_id": "Q9CNC4" }, { "db_name": "UniProt", "db_id": "Q9JUV5" } ] }, { "id": "DS.d410.s0.e1", "type": "compound", "text": [ "sialic acid" ], "offsets": [ [ 137, 148 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "906" }, { "db_name": "PubChem", "db_id": "444885" }, { "db_name": "PubChem", "db_id": "445063" } ] } ]
[]
[]
[ { "id": "DS.d410.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d410.s0.e1", "arg2_id": "DS.d410.s0.e0", "normalized": [] } ]
DS.d411
18590587
[ { "id": "DS.d411.s0", "type": "", "text": [ "NOPE-EGCG treatment improved insulin 0.0001)." ], "offsets": [ [ 0, 45 ] ] } ]
[ { "id": "DS.d411.s0.e0", "type": "compound", "text": [ "EGCG" ], "offsets": [ [ 5, 9 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "65064" } ] }, { "id": "DS.d411.s0.e1", "type": "protein", "text": [ "insulin" ], "offsets": [ [ 29, 36 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01314" }, { "db_name": "UniProt", "db_id": "P01316" }, { "db_name": "UniProt", "db_id": "P01319" }, { "db_name": "UniProt", "db_id": "P01320" }, { "db_name": "UniProt", "db_id": "P01324" }, { "db_name": "UniProt", "db_id": "P01328" }, { "db_name": "UniProt", "db_id": "P01330" }, { "db_name": "UniProt", "db_id": "P01331" }, { "db_name": "UniProt", "db_id": "P01334" }, { "db_name": "UniProt", "db_id": "P01336" }, { "db_name": "UniProt", "db_id": "P01340" }, { "db_name": "UniProt", "db_id": "P07453" }, { "db_name": "UniProt", "db_id": "P09476" }, { "db_name": "UniProt", "db_id": "P09477" }, { "db_name": "UniProt", "db_id": "P0C236" }, { "db_name": "UniProt", "db_id": "P12703" }, { "db_name": "UniProt", "db_id": "P12704" }, { "db_name": "UniProt", "db_id": "P12708" }, { "db_name": "UniProt", "db_id": "P13190" }, { "db_name": "UniProt", "db_id": "P18109" }, { "db_name": "UniProt", "db_id": "P29335" }, { "db_name": "UniProt", "db_id": "P42633" }, { "db_name": "UniProt", "db_id": "P67968" }, { "db_name": "UniProt", "db_id": "P67969" }, { "db_name": "UniProt", "db_id": "P67971" }, { "db_name": "UniProt", "db_id": "P67973" }, { "db_name": "UniProt", "db_id": "P67974" }, { "db_name": "UniProt", "db_id": "P68243" }, { "db_name": "UniProt", "db_id": "P68245" }, { "db_name": "UniProt", "db_id": "P68987" }, { "db_name": "UniProt", "db_id": "P68988" }, { "db_name": "UniProt", "db_id": "P68989" }, { "db_name": "UniProt", "db_id": "P68990" }, { "db_name": "UniProt", "db_id": "P68991" }, { "db_name": "UniProt", "db_id": "P68992" }, { "db_name": "UniProt", "db_id": "P69046" }, { "db_name": "UniProt", "db_id": "P69047" }, { "db_name": "UniProt", "db_id": "P69048" }, { "db_name": "UniProt", "db_id": "P81423" }, { "db_name": "UniProt", "db_id": "P81881" }, { "db_name": "UniProt", "db_id": "Q9TQY7" } ] } ]
[]
[]
[ { "id": "DS.d411.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d411.s0.e0", "arg2_id": "DS.d411.s0.e1", "normalized": [] } ]
DS.d412
18590597
[ { "id": "DS.d412.s0", "type": "", "text": [ "A 23.5-fold increase in 7-ethoxy-4-trifluoromethylcoumarin O-deethylation activity suggested that metabolic resistance through elevated levels of cytochrome P450 dependent monooxygenase-activity is a possible resistance mechanism.However, synergism studies with different metabolic inhibitors revealed some contrasting resistance mechanisms between the METI-acaricides." ], "offsets": [ [ 0, 369 ] ] } ]
[ { "id": "DS.d412.s0.e0", "type": "compound", "text": [ "7-ethoxy-4-trifluoromethylcoumarin" ], "offsets": [ [ 24, 58 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "130779" } ] }, { "id": "DS.d412.s0.e1", "type": "protein", "text": [ "cytochrome P450" ], "offsets": [ [ 146, 161 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O08469" } ] } ]
[]
[]
[ { "id": "DS.d412.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d412.s0.e0", "arg2_id": "DS.d412.s0.e1", "normalized": [] } ]
DS.d413
18592271
[ { "id": "DS.d413.s0", "type": "", "text": [ "The activities of Rho GTPases are predominantly controlled by guanine nucleotide exchange factors (GEFs), which activate GTPases by catalyzing the exchange of bound GDP for GTP." ], "offsets": [ [ 0, 177 ] ] } ]
[ { "id": "DS.d413.s0.e1", "type": "protein", "text": [ "GEFs" ], "offsets": [ [ 99, 103 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q9NR83" } ] }, { "id": "DS.d413.s0.e2", "type": "compound", "text": [ "GDP" ], "offsets": [ [ 165, 168 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "8977" } ] } ]
[]
[]
[ { "id": "DS.d413.s0.i3", "type": "compound-protein-interaction", "arg1_id": "DS.d413.s0.e2", "arg2_id": "DS.d413.s0.e1", "normalized": [] } ]
DS.d414
18592327
[ { "id": "DS.d414.s0", "type": "", "text": [ "11beta-Hydroxysteroid dehydrogenase type 1 (11beta-HSD1) enzyme catalyzes interconversion of inactive cortisone to active cortisol." ], "offsets": [ [ 0, 131 ] ] } ]
[ { "id": "DS.d414.s0.e0", "type": "protein", "text": [ "11beta-HSD1" ], "offsets": [ [ 44, 55 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P16232" }, { "db_name": "UniProt", "db_id": "P28845" }, { "db_name": "UniProt", "db_id": "P50172" }, { "db_name": "UniProt", "db_id": "P51975" }, { "db_name": "UniProt", "db_id": "Q29608" }, { "db_name": "UniProt", "db_id": "Q6QLL4" }, { "db_name": "UniProt", "db_id": "Q6R0J2" }, { "db_name": "UniProt", "db_id": "Q7M3I4" } ] }, { "id": "DS.d414.s0.e1", "type": "compound", "text": [ "cortisone" ], "offsets": [ [ 102, 111 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "222786" } ] }, { "id": "DS.d414.s0.e2", "type": "compound", "text": [ "cortisol" ], "offsets": [ [ 122, 130 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5754" } ] } ]
[]
[]
[ { "id": "DS.d414.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d414.s0.e2", "arg2_id": "DS.d414.s0.e0", "normalized": [] }, { "id": "DS.d414.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d414.s0.e1", "arg2_id": "DS.d414.s0.e0", "normalized": [] } ]
DS.d415
18592344
[ { "id": "DS.d415.s0", "type": "", "text": [ "Rebinding experiments with Lys-Gly-Asp, an analogue of Arg-Gly-Asp, and other different peptides, such as cholecystokinin C-terminal tri- and pentapeptide and gramicidin, further indicated the selectivity of methacrylic acid-trimethylpropane trimethacrylate copolymer for Arg-Gly-Asp giving specific selectivity factor values 1.27, 1.98, 1.31 and 1.67, respectively." ], "offsets": [ [ 0, 366 ] ] } ]
[ { "id": "DS.d415.s0.e2", "type": "protein", "text": [ "cholecystokinin" ], "offsets": [ [ 106, 121 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P0C229" }, { "db_name": "UniProt", "db_id": "P50144" }, { "db_name": "UniProt", "db_id": "P50145" }, { "db_name": "UniProt", "db_id": "P68125" }, { "db_name": "UniProt", "db_id": "P68126" } ] }, { "id": "DS.d415.s0.e4", "type": "compound", "text": [ "gramicidin" ], "offsets": [ [ 159, 169 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "16130140" } ] } ]
[]
[]
[]
DS.d416
18592367
[ { "id": "DS.d416.s0", "type": "", "text": [ "Parents (N = 19) of children with autism spectrum disorders (ASD) and adult controls (N = 17) underwent positron emission tomography (PET) using ((18)F) setoperone to image cortical serotonin type-2 (5-HT2) receptors." ], "offsets": [ [ 0, 217 ] ] } ]
[ { "id": "DS.d416.s0.e0", "type": "compound", "text": [ "setoperone" ], "offsets": [ [ 153, 163 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "68604" } ] }, { "id": "DS.d416.s0.e1", "type": "protein", "text": [ "5-HT2" ], "offsets": [ [ 200, 205 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O46635" }, { "db_name": "UniProt", "db_id": "P14842" }, { "db_name": "UniProt", "db_id": "P18599" }, { "db_name": "UniProt", "db_id": "P28223" }, { "db_name": "UniProt", "db_id": "P35363" }, { "db_name": "UniProt", "db_id": "P35382" }, { "db_name": "UniProt", "db_id": "P50128" }, { "db_name": "UniProt", "db_id": "P50129" }, { "db_name": "UniProt", "db_id": "Q5R4Q6" }, { "db_name": "UniProt", "db_id": "Q75Z89" } ] } ]
[]
[]
[ { "id": "DS.d416.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d416.s0.e0", "arg2_id": "DS.d416.s0.e1", "normalized": [] } ]
DS.d417
18592408
[ { "id": "DS.d417.s0", "type": "", "text": [ "Natural anacardic acid was enzymatically polymerized using soybean peroxidase." ], "offsets": [ [ 0, 78 ] ] } ]
[ { "id": "DS.d417.s0.e0", "type": "compound", "text": [ "anacardic acid" ], "offsets": [ [ 8, 22 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "167551" } ] }, { "id": "DS.d417.s0.e1", "type": "protein", "text": [ "peroxidase" ], "offsets": [ [ 67, 77 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P15984" }, { "db_name": "UniProt", "db_id": "P16147" }, { "db_name": "UniProt", "db_id": "P84714" } ] } ]
[]
[]
[ { "id": "DS.d417.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d417.s0.e0", "arg2_id": "DS.d417.s0.e1", "normalized": [] } ]
DS.d418
18592416
[ { "id": "DS.d418.s0", "type": "", "text": [ "Vesicle mobilization requires Ca(2+)-induced Ca2+ release by presynaptic endoplasmic reticulum (ER) ryanodine receptors (RyRs) that in turn stimulates Ca2+/calmodulin-dependent kinase II (CamKII)." ], "offsets": [ [ 0, 196 ] ] } ]
[ { "id": "DS.d418.s0.e0", "type": "compound", "text": [ "Ca(2" ], "offsets": [ [ 30, 34 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "271" } ] }, { "id": "DS.d418.s0.e1", "type": "protein", "text": [ "RyRs" ], "offsets": [ [ 121, 125 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q24498" } ] } ]
[]
[]
[ { "id": "DS.d418.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d418.s0.e0", "arg2_id": "DS.d418.s0.e1", "normalized": [] } ]
DS.d419
18593507
[ { "id": "DS.d419.s0", "type": "", "text": [ "These results highlight both the interactions between mGluR5 and NMDA receptors in the determination of schizophreniform behaviours and the potential for the effects of clozapine to be mediated by NMDA receptor regulation." ], "offsets": [ [ 0, 222 ] ] } ]
[ { "id": "DS.d419.s0.e0", "type": "protein", "text": [ "mGluR5" ], "offsets": [ [ 54, 60 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P31424" }, { "db_name": "UniProt", "db_id": "P41594" } ] }, { "id": "DS.d419.s0.e1", "type": "compound", "text": [ "clozapine" ], "offsets": [ [ 169, 178 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2818" } ] } ]
[]
[]
[]
DS.d420
18594129
[ { "id": "DS.d420.s0", "type": "", "text": [ "Expression of rhtC reduced the intracellular L-threonine concentration from 140 to 11 mM and resulted in maximal excretion rates of 11.2 nmol min(-1) mg(-1) as compared to 2.3 nmol min(-1) mg(-1) obtained without rhtC expression." ], "offsets": [ [ 0, 229 ] ] }, { "id": "DS.d420.s1", "type": "", "text": [ "In combination with an ilvA mutation generated and introduced into the chromosome, an accumulation of up to 54 mM L-threonine was achieved as compared to 21 mM obtained with the ancestor strain." ], "offsets": [ [ 230, 424 ] ] } ]
[ { "id": "DS.d420.s0.e0", "type": "protein", "text": [ "rhtC" ], "offsets": [ [ 14, 18 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P0AG38" }, { "db_name": "UniProt", "db_id": "P0AG39" }, { "db_name": "UniProt", "db_id": "Q8Z3B3" }, { "db_name": "UniProt", "db_id": "Q9L6N7" } ] }, { "id": "DS.d420.s0.e1", "type": "compound", "text": [ "L-threonine" ], "offsets": [ [ 45, 56 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6288" } ] }, { "id": "DS.d420.s0.e2", "type": "protein", "text": [ "rhtC" ], "offsets": [ [ 213, 217 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P0AG38" }, { "db_name": "UniProt", "db_id": "P0AG39" }, { "db_name": "UniProt", "db_id": "Q8Z3B3" }, { "db_name": "UniProt", "db_id": "Q9L6N7" } ] }, { "id": "DS.d420.s1.e0", "type": "protein", "text": [ "ilvA" ], "offsets": [ [ 253, 257 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P04968" }, { "db_name": "UniProt", "db_id": "P20506" }, { "db_name": "UniProt", "db_id": "P37946" }, { "db_name": "UniProt", "db_id": "P46493" }, { "db_name": "UniProt", "db_id": "P53607" }, { "db_name": "UniProt", "db_id": "P66897" }, { "db_name": "UniProt", "db_id": "P66898" }, { "db_name": "UniProt", "db_id": "Q02145" }, { "db_name": "UniProt", "db_id": "Q04513" }, { "db_name": "UniProt", "db_id": "Q2FF63" }, { "db_name": "UniProt", "db_id": "Q2YUE8" }, { "db_name": "UniProt", "db_id": "Q3V7T4" }, { "db_name": "UniProt", "db_id": "Q3V7T5" }, { "db_name": "UniProt", "db_id": "Q49Z16" }, { "db_name": "UniProt", "db_id": "Q4L7U4" }, { "db_name": "UniProt", "db_id": "Q5HEE0" }, { "db_name": "UniProt", "db_id": "Q5HMF5" }, { "db_name": "UniProt", "db_id": "Q7A4H2" }, { "db_name": "UniProt", "db_id": "Q8CNK9" }, { "db_name": "UniProt", "db_id": "Q8NVI8" }, { "db_name": "UniProt", "db_id": "Q99SJ1" }, { "db_name": "UniProt", "db_id": "Q9CKJ2" }, { "db_name": "UniProt", "db_id": "Q9KC63" }, { "db_name": "UniProt", "db_id": "Q9X7F1" } ] }, { "id": "DS.d420.s1.e1", "type": "compound", "text": [ "L-threonine" ], "offsets": [ [ 344, 355 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6288" } ] } ]
[]
[]
[ { "id": "DS.d420.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d420.s0.e1", "arg2_id": "DS.d420.s0.e0", "normalized": [] }, { "id": "DS.d420.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d420.s1.e1", "arg2_id": "DS.d420.s1.e0", "normalized": [] } ]
DS.d421
18594817
[ { "id": "DS.d421.s0", "type": "", "text": [ "This additive effect was not observed when glioma cells were pre-treated with temozolomide, which was unable to increase Fas expression in tumor." ], "offsets": [ [ 0, 145 ] ] }, { "id": "DS.d421.s1", "type": "", "text": [ "Furthermore, the CD3(+) T cells co-cultured with topotecan treated U-87 and autologous GBM tumor cells showed a significant increase in expression in IFN-gamma, a key cytokine produced by activated T cells, and accordingly enhanced tumor cytotoxicity." ], "offsets": [ [ 146, 397 ] ] } ]
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[]
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[ { "id": "DS.d421.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d421.s1.e0", "arg2_id": "DS.d421.s1.e1", "normalized": [] } ]
DS.d422
18594856
[ { "id": "DS.d422.s0", "type": "", "text": [ "Hypergravity also induced a transient reorganization of actin fibers in 3 min, which was inhibited by Rho-kinase inhibitor (Y27632) and tyrosine kinase inhibitors (herbimycin A and tyrphostin 46)." ], "offsets": [ [ 0, 196 ] ] }, { "id": "DS.d422.s1", "type": "", "text": [ "Collectively, these results indicate that hypergravity induces ATP release and actin reorganization via RhoA activation and FAK phosphorylation, thereby activating cell proliferation and migration in BAECs." ], "offsets": [ [ 197, 403 ] ] } ]
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}, { "db_name": "UniProt", "db_id": "P90689" }, { "db_name": "UniProt", "db_id": "P91754" }, { "db_name": "UniProt", "db_id": "Q05214" }, { "db_name": "UniProt", "db_id": "Q11212" }, { "db_name": "UniProt", "db_id": "Q24733" }, { "db_name": "UniProt", "db_id": "Q2U7A3" }, { "db_name": "UniProt", "db_id": "Q39596" }, { "db_name": "UniProt", "db_id": "Q39758" }, { "db_name": "UniProt", "db_id": "Q6TCF2" }, { "db_name": "UniProt", "db_id": "Q75D00" }, { "db_name": "UniProt", "db_id": "Q8SWN8" }, { "db_name": "UniProt", "db_id": "Q8X119" }, { "db_name": "UniProt", "db_id": "Q92192" }, { "db_name": "UniProt", "db_id": "Q92193" }, { "db_name": "UniProt", "db_id": "Q99023" }, { "db_name": "UniProt", "db_id": "Q9P4D1" }, { "db_name": "UniProt", "db_id": "Q9UVF3" }, { "db_name": "UniProt", "db_id": "Q9UVX4" }, { "db_name": "UniProt", "db_id": "Q9UVZ8" } ] }, { "id": "DS.d422.s0.e1", "type": "compound", "text": [ "Y27632" ], "offsets": [ [ 124, 130 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "448042" } ] }, { "id": "DS.d422.s0.e2", "type": "compound", "text": [ "herbimycin A" ], "offsets": [ [ 164, 176 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "3591" }, { "db_name": "PubChem", "db_id": "5311102" }, { "db_name": "PubChem", "db_id": "6436247" } ] }, { "id": "DS.d422.s0.e3", "type": "compound", "text": [ "tyrphostin 46" ], "offsets": [ [ 181, 194 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5328768" } ] }, { "id": "DS.d422.s1.e0", "type": "compound", "text": [ "ATP" ], "offsets": [ [ 260, 263 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5957" } ] }, { "id": "DS.d422.s1.e1", "type": "protein", "text": [ "actin" ], "offsets": [ [ 276, 281 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O00937" }, { "db_name": "UniProt", "db_id": "O13419" }, { "db_name": "UniProt", "db_id": "O16808" }, { "db_name": "UniProt", "db_id": "O17320" }, { "db_name": "UniProt", "db_id": "O65314" }, { "db_name": "UniProt", "db_id": "O65315" }, { "db_name": 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"db_id": "P53477" }, { "db_name": "UniProt", "db_id": "P53491" }, { "db_name": "UniProt", "db_id": "P53498" }, { "db_name": "UniProt", "db_id": "P53499" }, { "db_name": "UniProt", "db_id": "P53500" }, { "db_name": "UniProt", "db_id": "P53502" }, { "db_name": "UniProt", "db_id": "P53689" }, { "db_name": "UniProt", "db_id": "P60009" }, { "db_name": "UniProt", "db_id": "P60010" }, { "db_name": "UniProt", "db_id": "P60011" }, { "db_name": "UniProt", "db_id": "P68555" }, { "db_name": "UniProt", "db_id": "P78711" }, { "db_name": "UniProt", "db_id": "P80709" }, { "db_name": "UniProt", "db_id": "P81085" }, { "db_name": "UniProt", "db_id": "P90689" }, { "db_name": "UniProt", "db_id": "P91754" }, { "db_name": "UniProt", "db_id": "Q05214" }, { "db_name": "UniProt", "db_id": "Q11212" }, { "db_name": "UniProt", "db_id": "Q24733" }, { "db_name": "UniProt", "db_id": "Q2U7A3" }, { "db_name": "UniProt", "db_id": "Q39596" }, { "db_name": "UniProt", "db_id": "Q39758" }, { "db_name": "UniProt", "db_id": "Q6TCF2" }, { "db_name": "UniProt", "db_id": "Q75D00" }, { "db_name": "UniProt", "db_id": "Q8SWN8" }, { "db_name": "UniProt", "db_id": "Q8X119" }, { "db_name": "UniProt", "db_id": "Q92192" }, { "db_name": "UniProt", "db_id": "Q92193" }, { "db_name": "UniProt", "db_id": "Q99023" }, { "db_name": "UniProt", "db_id": "Q9P4D1" }, { "db_name": "UniProt", "db_id": "Q9UVF3" }, { "db_name": "UniProt", "db_id": "Q9UVX4" }, { "db_name": "UniProt", "db_id": "Q9UVZ8" } ] }, { "id": "DS.d422.s1.e2", "type": "protein", "text": [ "RhoA" ], "offsets": [ [ 301, 305 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q9C3Y4" } ] }, { "id": "DS.d422.s1.e3", "type": "protein", "text": [ "FAK" ], "offsets": [ [ 321, 324 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q00944" }, { "db_name": "UniProt", "db_id": "Q05397" } ] } ]
[]
[]
[ { "id": "DS.d422.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d422.s0.e1", "arg2_id": "DS.d422.s0.e0", "normalized": [] }, { "id": "DS.d422.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d422.s0.e2", "arg2_id": "DS.d422.s0.e0", "normalized": [] }, { "id": "DS.d422.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d422.s0.e3", "arg2_id": "DS.d422.s0.e0", "normalized": [] }, { "id": "DS.d422.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d422.s1.e0", "arg2_id": "DS.d422.s1.e3", "normalized": [] }, { "id": "DS.d422.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d422.s1.e0", "arg2_id": "DS.d422.s1.e2", "normalized": [] } ]
DS.d423
18594946
[ { "id": "DS.d423.s0", "type": "", "text": [ "Cell exposure to 250 microM homocysteine was able to induce transglutaminase 2 up-regulation and increased in situ transglutaminase activity." ], "offsets": [ [ 0, 141 ] ] }, { "id": "DS.d423.s1", "type": "", "text": [ "Homocysteine also induced NF-kappaB activation that seemed associated with transglutaminase 2 up-regulation since the specific NF-kappaB inhibition by SN50 was able to reduce transglutaminase expression and activity levels." ], "offsets": [ [ 142, 365 ] ] } ]
[ { "id": "DS.d423.s0.e0", "type": "compound", "text": [ "homocysteine" ], "offsets": [ [ 28, 40 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "778" } ] }, { "id": "DS.d423.s0.e1", "type": "protein", "text": [ "transglutaminase 2" ], "offsets": [ [ 60, 78 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P08587" }, { "db_name": "UniProt", "db_id": "P21980" }, { "db_name": "UniProt", "db_id": "P21981" }, { "db_name": "UniProt", "db_id": "P51176" }, { "db_name": "UniProt", "db_id": "P52181" }, { "db_name": "UniProt", "db_id": "Q01841" } ] }, { "id": "DS.d423.s0.e2", "type": "protein", "text": [ "transglutaminase" ], "offsets": [ [ 60, 76 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P40746" }, { "db_name": "UniProt", "db_id": "P52183" }, { "db_name": "UniProt", "db_id": "P81453" }, { "db_name": "UniProt", "db_id": "Q819L3" }, { "db_name": "UniProt", "db_id": "Q81MS1" }, { "db_name": "UniProt", "db_id": "Q8GR90" }, { "db_name": "UniProt", "db_id": "Q9K5W7" } ] }, { "id": "DS.d423.s1.e0", "type": "compound", "text": [ "Homocysteine" ], "offsets": [ [ 142, 154 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "778" } ] }, { "id": "DS.d423.s1.e1", "type": "protein", "text": [ "transglutaminase 2" ], "offsets": [ [ 217, 235 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P08587" }, { "db_name": "UniProt", "db_id": "P21980" }, { "db_name": "UniProt", "db_id": "P21981" }, { "db_name": "UniProt", "db_id": "P51176" }, { "db_name": "UniProt", "db_id": "P52181" }, { "db_name": "UniProt", "db_id": "Q01841" } ] }, { "id": "DS.d423.s1.e2", "type": "protein", "text": [ "transglutaminase" ], "offsets": [ [ 217, 233 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P40746" }, { "db_name": "UniProt", "db_id": "P52183" }, { "db_name": "UniProt", "db_id": "P81453" }, { "db_name": "UniProt", "db_id": "Q819L3" }, { "db_name": "UniProt", "db_id": "Q81MS1" }, { "db_name": "UniProt", "db_id": "Q8GR90" }, { "db_name": "UniProt", "db_id": "Q9K5W7" } ] } ]
[]
[]
[ { "id": "DS.d423.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d423.s0.e0", "arg2_id": "DS.d423.s0.e2", "normalized": [] }, { "id": "DS.d423.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d423.s0.e0", "arg2_id": "DS.d423.s0.e1", "normalized": [] }, { "id": "DS.d423.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d423.s1.e0", "arg2_id": "DS.d423.s1.e2", "normalized": [] }, { "id": "DS.d423.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d423.s1.e0", "arg2_id": "DS.d423.s1.e1", "normalized": [] } ]
DS.d424
18594965
[ { "id": "DS.d424.s0", "type": "", "text": [ "Lysophosphatidic acid can support the formation of membranous structures and an increase in MBP mRNA levels in differentiating oligodendrocytes." ], "offsets": [ [ 0, 144 ] ] } ]
[ { "id": "DS.d424.s0.e0", "type": "compound", "text": [ "Lysophosphatidic acid" ], "offsets": [ [ 0, 21 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "3988" }, { "db_name": "PubChem", "db_id": "5311263" }, { "db_name": "PubChem", "db_id": "5497152" } ] }, { "id": "DS.d424.s0.e1", "type": "protein", "text": [ "MBP" ], "offsets": [ [ 92, 95 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P02686" }, { "db_name": "UniProt", "db_id": "P02687" }, { "db_name": "UniProt", "db_id": "P04370" }, { "db_name": "UniProt", "db_id": "P06906" }, { "db_name": "UniProt", "db_id": "P13727" }, { "db_name": "UniProt", "db_id": "P15720" }, { "db_name": "UniProt", "db_id": "P20939" }, { "db_name": "UniProt", "db_id": "P25188" }, { "db_name": "UniProt", "db_id": "P25274" }, { "db_name": "UniProt", "db_id": "P25336" }, { "db_name": "UniProt", "db_id": "P81558" }, { "db_name": "UniProt", "db_id": "P83487" }, { "db_name": "UniProt", "db_id": "P87346" }, { "db_name": "UniProt", "db_id": "P98190" }, { "db_name": "UniProt", "db_id": "Q61878" }, { "db_name": "UniProt", "db_id": "Q63189" }, { "db_name": "UniProt", "db_id": "Q91325" }, { "db_name": "UniProt", "db_id": "Q91439" }, { "db_name": "UniProt", "db_id": "Q9SAV1" } ] } ]
[]
[]
[ { "id": "DS.d424.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d424.s0.e0", "arg2_id": "DS.d424.s0.e1", "normalized": [] } ]
DS.d425
18594989
[ { "id": "DS.d425.s0", "type": "", "text": [ "There was no correlation between the presence of significant heart-valve regurgitation and cabergoline cumulative dose, duration of cabergoline treatment, prior use of bromocriptine, age, adenoma size, or prolactin levels." ], "offsets": [ [ 0, 222 ] ] } ]
[ { "id": "DS.d425.s0.e0", "type": "compound", "text": [ "cabergoline" ], "offsets": [ [ 91, 102 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "54746" } ] }, { "id": "DS.d425.s0.e1", "type": "compound", "text": [ "cabergoline" ], "offsets": [ [ 132, 143 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "54746" } ] }, { "id": "DS.d425.s0.e2", "type": "compound", "text": [ "bromocriptine" ], "offsets": [ [ 168, 181 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "31101" } ] }, { "id": "DS.d425.s0.e3", "type": "protein", "text": [ "prolactin" ], "offsets": [ [ 205, 214 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P10765" }, { "db_name": "UniProt", "db_id": "P22393" }, { "db_name": "UniProt", "db_id": "P33089" }, { "db_name": "UniProt", "db_id": "P33090" }, { "db_name": "UniProt", "db_id": "P33091" }, { "db_name": "UniProt", "db_id": "P43001" } ] } ]
[]
[]
[]
DS.d426
18595002
[ { "id": "DS.d426.s0", "type": "", "text": [ "CHH elevates glucose levels in the hemolymph by stimulating glycogenolysis in target tissues." ], "offsets": [ [ 0, 93 ] ] } ]
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DS.d427
18596195
[ { "id": "DS.d427.s0", "type": "", "text": [ "Here, we assessed the regulation of pancreatic cytochrome c release by Ca(2+), mitochondrial membrane potential (Delta Psi m), and reactive oxygen species (ROS), the signals involved in acute pancreatitis." ], "offsets": [ [ 0, 205 ] ] } ]
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"db_name": "UniProt", "db_id": "P62895" }, { "db_name": "UniProt", "db_id": "P62896" }, { "db_name": "UniProt", "db_id": "P67881" }, { "db_name": "UniProt", "db_id": "P67882" }, { "db_name": "UniProt", "db_id": "P68096" }, { "db_name": "UniProt", "db_id": "P68097" }, { "db_name": "UniProt", "db_id": "P68098" }, { "db_name": "UniProt", "db_id": "P68099" }, { "db_name": "UniProt", "db_id": "P68100" }, { "db_name": "UniProt", "db_id": "P68517" }, { "db_name": "UniProt", "db_id": "P68518" }, { "db_name": "UniProt", "db_id": "P68519" }, { "db_name": "UniProt", "db_id": "P81280" }, { "db_name": "UniProt", "db_id": "P81459" }, { "db_name": "UniProt", "db_id": "P99998" }, { "db_name": "UniProt", "db_id": "P99999" }, { "db_name": "UniProt", "db_id": "Q41346" }, { "db_name": "UniProt", "db_id": "Q4HVX7" }, { "db_name": "UniProt", "db_id": "Q52V08" }, { "db_name": "UniProt", "db_id": "Q52V09" }, { "db_name": "UniProt", "db_id": "Q52V10" }, { "db_name": "UniProt", "db_id": "Q5RFH4" }, { "db_name": "UniProt", "db_id": "Q640U4" }, { "db_name": "UniProt", "db_id": "Q6C9Q0" }, { "db_name": "UniProt", "db_id": "Q6IQM2" }, { "db_name": "UniProt", "db_id": "Q6Q4H8" }, { "db_name": "UniProt", "db_id": "Q6QLW4" }, { "db_name": "UniProt", "db_id": "Q6WUX8" }, { "db_name": "UniProt", "db_id": "Q753F4" }, { "db_name": "UniProt", "db_id": "Q7YR71" }, { "db_name": "UniProt", "db_id": "Q96VP3" } ] }, { "id": "DS.d427.s0.e1", "type": "compound", "text": [ "Ca(2" ], "offsets": [ [ 71, 75 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "271" } ] } ]
[]
[]
[ { "id": "DS.d427.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d427.s0.e1", "arg2_id": "DS.d427.s0.e0", "normalized": [] } ]
DS.d428
18596687
[ { "id": "DS.d428.s0", "type": "", "text": [ "Here, we report the efficacy of betaxolol in reducing increases in gene expression of amygdalar corticotropin-releasing factor (CRF), a peptide known to be involved in mediating 'anxiety-like' behaviors during initial phases of cocaine abstinence." ], "offsets": [ [ 0, 247 ] ] }, { "id": "DS.d428.s1", "type": "", "text": [ "Results showed that betaxolol treatment during early cocaine withdrawal attenuated increases in amygdalar CRF gene expression and cyclic adenosine monophosphate-dependent protein kinase regulatory and catalytic subunit (nuclear fraction) protein expression." ], "offsets": [ [ 248, 505 ] ] }, { "id": "DS.d428.s2", "type": "", "text": [ "The present findings suggest that the efficacy of betaxolol treatment on cocaine withdrawal-induced anxiety may be related, in part, to its effect on amygdalar beta(1)-adrenergic receptor, modulation of its downstream cell-signaling elements and CRF gene expression." ], "offsets": [ [ 506, 772 ] ] } ]
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[]
[]
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DS.d429
18597051
[ { "id": "DS.d429.s0", "type": "", "text": [ "Furthermore, it is demonstrated that this strain has xylanase activity, and the activity can be optimized under suitable growing conditions where wheat bran and urea are the primary sources of carbon and nitrogen." ], "offsets": [ [ 0, 213 ] ] } ]
[ { "id": "DS.d429.s0.e0", "type": "protein", "text": [ "xylanase" ], "offsets": [ [ 53, 61 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O43097" }, { "db_name": "UniProt", "db_id": "O59859" }, { "db_name": "UniProt", "db_id": "O60206" }, { "db_name": "UniProt", "db_id": "P07529" }, { "db_name": "UniProt", "db_id": "P09850" }, { "db_name": "UniProt", "db_id": "P17137" }, { "db_name": "UniProt", "db_id": "P23360" }, { "db_name": "UniProt", "db_id": "P23557" }, { "db_name": "UniProt", "db_id": "P29417" }, { "db_name": "UniProt", "db_id": "P40943" }, { "db_name": "UniProt", "db_id": "P45703" }, { "db_name": "UniProt", "db_id": "P48793" }, { "db_name": "UniProt", "db_id": "P56588" }, { "db_name": "UniProt", "db_id": "P81536" }, { "db_name": "UniProt", "db_id": "Q53317" } ] }, { "id": "DS.d429.s0.e1", "type": "compound", "text": [ "urea" ], "offsets": [ [ 161, 165 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1176" }, { "db_name": "PubChem", "db_id": "265993" } ] }, { "id": "DS.d429.s0.e2", "type": "compound", "text": [ "nitrogen" ], "offsets": [ [ 204, 212 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "947" }, { "db_name": "PubChem", "db_id": "123329" } ] } ]
[]
[]
[]
DS.d430
18597073
[ { "id": "DS.d430.s0", "type": "", "text": [ "Glutathione S-transferase (GST) isozymes catalyze nucleophilic attack by reduced Glutathione (GSH) on a variety of electrophilic compounds and play a central role in biotransformation of xenobiotics (Hayes et al., Annu Rev Pharmacol Toxicol 45:51-88, 2005)." ], "offsets": [ [ 0, 257 ] ] } ]
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[]
[]
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DS.d431
18597869
[ { "id": "DS.d431.s0", "type": "", "text": [ "Metformin inhibits TNF-alpha-induced IkappaB kinase phosphorylation, IkappaB-alpha degradation and IL-6 production in endothelial cells through PI3K-dependent AMPK phosphorylation." ], "offsets": [ [ 0, 180 ] ] } ]
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], "normalized": [ { "db_name": "UniProt", "db_id": "O15111" }, { "db_name": "UniProt", "db_id": "Q60680" } ] }, { "id": "DS.d431.s0.e3", "type": "protein", "text": [ "IkappaB-alpha" ], "offsets": [ [ 69, 82 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P25963" }, { "db_name": "UniProt", "db_id": "Q08353" }, { "db_name": "UniProt", "db_id": "Q63746" }, { "db_name": "UniProt", "db_id": "Q91974" }, { "db_name": "UniProt", "db_id": "Q9Z1E3" } ] }, { "id": "DS.d431.s0.e4", "type": "protein", "text": [ "IL-6" ], "offsets": [ [ 99, 103 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O35736" }, { "db_name": "UniProt", "db_id": "P05231" }, { "db_name": "UniProt", "db_id": "P08505" }, { "db_name": "UniProt", "db_id": "P20607" }, { "db_name": "UniProt", "db_id": "P26892" }, { "db_name": "UniProt", "db_id": "P26893" }, { "db_name": "UniProt", "db_id": "P29455" }, { "db_name": "UniProt", "db_id": "P41323" }, { "db_name": "UniProt", "db_id": "P41683" }, { "db_name": "UniProt", "db_id": "P41693" }, { "db_name": "UniProt", "db_id": "P46650" }, { "db_name": "UniProt", "db_id": "P51494" }, { "db_name": "UniProt", "db_id": "P79341" }, { "db_name": "UniProt", "db_id": "Q25BC2" }, { "db_name": "UniProt", "db_id": "Q28319" }, { "db_name": "UniProt", "db_id": "Q28747" }, { "db_name": "UniProt", "db_id": "Q28819" }, { "db_name": "UniProt", "db_id": "Q2MH06" }, { "db_name": "UniProt", "db_id": "Q5I6E3" }, { "db_name": "UniProt", "db_id": "Q6V919" }, { "db_name": "UniProt", "db_id": "Q865W7" }, { "db_name": "UniProt", "db_id": "Q865X6" }, { "db_name": "UniProt", "db_id": "Q8MKH0" }, { "db_name": "UniProt", "db_id": "Q95181" }, { "db_name": "UniProt", "db_id": "Q9MZR1" }, { "db_name": "UniProt", "db_id": "Q9XT80" } ] }, { "id": "DS.d431.s0.e5", "type": "protein", "text": [ "PI3K" ], "offsets": [ [ 144, 148 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O00329" }, { "db_name": "UniProt", "db_id": "O02697" }, { "db_name": "UniProt", "db_id": "O35904" }, { "db_name": "UniProt", "db_id": "P23727" }, { "db_name": "UniProt", "db_id": "P26450" }, { "db_name": "UniProt", "db_id": "P27986" }, { "db_name": "UniProt", "db_id": "P32871" }, { "db_name": "UniProt", "db_id": "P42336" }, { "db_name": "UniProt", "db_id": "P42337" }, { "db_name": "UniProt", "db_id": "P42338" }, { "db_name": "UniProt", "db_id": "P42347" }, { "db_name": "UniProt", "db_id": "P42348" }, { "db_name": "UniProt", "db_id": "P48736" }, { "db_name": "UniProt", "db_id": "P54673" }, { "db_name": "UniProt", "db_id": "P54674" }, { "db_name": "UniProt", "db_id": "P54675" }, { "db_name": "UniProt", "db_id": "P54676" }, { "db_name": "UniProt", "db_id": "Q63787" }, { "db_name": "UniProt", "db_id": "Q8BTI9" }, { "db_name": "UniProt", "db_id": "Q8UUU2" }, { "db_name": "UniProt", "db_id": "Q9JHG7" }, { "db_name": "UniProt", "db_id": "Q9Z1L0" } ] }, { "id": "DS.d431.s0.e6", "type": "protein", "text": [ "AMPK" ], "offsets": [ [ 159, 163 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P54646" }, { "db_name": "UniProt", "db_id": "Q09136" }, { "db_name": "UniProt", "db_id": "Q9Y478" } ] } ]
[]
[]
[ { "id": "DS.d431.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d431.s0.e0", "arg2_id": "DS.d431.s0.e6", "normalized": [] }, { "id": "DS.d431.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d431.s0.e0", "arg2_id": "DS.d431.s0.e5", "normalized": [] }, { "id": "DS.d431.s0.i3", "type": "compound-protein-interaction", "arg1_id": "DS.d431.s0.e0", "arg2_id": "DS.d431.s0.e3", "normalized": [] }, { "id": "DS.d431.s0.i4", "type": "compound-protein-interaction", "arg1_id": "DS.d431.s0.e0", "arg2_id": "DS.d431.s0.e4", "normalized": [] }, { "id": "DS.d431.s0.i5", "type": "compound-protein-interaction", "arg1_id": "DS.d431.s0.e0", "arg2_id": "DS.d431.s0.e2", "normalized": [] } ]
DS.d432
18599066
[ { "id": "DS.d432.s0", "type": "", "text": [ "Palmitate phosphorylated p38 and JNK kinases, and blocking of these kinases with specific inhibitors diminished the palmitate-induced cytokine secretion." ], "offsets": [ [ 0, 153 ] ] }, { "id": "DS.d432.s1", "type": "", "text": [ "Palmitate also activated the AP-1 (c-Jun) transcription factor." ], "offsets": [ [ 154, 217 ] ] } ]
[ { "id": "DS.d432.s0.e0", "type": "compound", "text": [ "Palmitate" ], "offsets": [ [ 0, 9 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "985" } ] }, { "id": "DS.d432.s0.e1", "type": "protein", "text": [ "p38" ], "offsets": [ [ 25, 28 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O24473" }, { "db_name": "UniProt", "db_id": "O75791" }, { "db_name": "UniProt", "db_id": "O95433" }, { "db_name": "UniProt", "db_id": "O97628" }, { "db_name": "UniProt", "db_id": "P46108" }, { "db_name": "UniProt", "db_id": "P80350" }, { "db_name": "UniProt", "db_id": "P82869" }, { "db_name": "UniProt", "db_id": "Q01552" }, { "db_name": "UniProt", "db_id": "Q04929" }, { "db_name": "UniProt", "db_id": "Q63768" }, { "db_name": "UniProt", "db_id": "Q64010" }, { "db_name": "UniProt", "db_id": "Q9LDA4" }, { "db_name": "UniProt", "db_id": "Q9Y2S7" } ] }, { "id": "DS.d432.s0.e2", "type": "protein", "text": [ "JNK" ], "offsets": [ [ 33, 36 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P92208" }, { "db_name": "UniProt", "db_id": "Q966Y3" } ] }, { "id": "DS.d432.s0.e3", "type": "compound", "text": [ "palmitate" ], "offsets": [ [ 116, 125 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "985" } ] }, { "id": "DS.d432.s1.e0", "type": "compound", "text": [ "Palmitate" ], "offsets": [ [ 154, 163 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "985" } ] }, { "id": "DS.d432.s1.e1", "type": "protein", "text": [ "AP-1" ], "offsets": [ [ 183, 187 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P21525" } ] } ]
[]
[]
[ { "id": "DS.d432.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d432.s0.e0", "arg2_id": "DS.d432.s0.e1", "normalized": [] }, { "id": "DS.d432.s0.i3", "type": "compound-protein-interaction", "arg1_id": "DS.d432.s0.e3", "arg2_id": "DS.d432.s0.e2", "normalized": [] }, { "id": "DS.d432.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d432.s1.e0", "arg2_id": "DS.d432.s1.e1", "normalized": [] } ]
DS.d433
18599093
[ { "id": "DS.d433.s0", "type": "", "text": [ "Characterisation of ATP analogues to cross-link and label P2X receptors." ], "offsets": [ [ 0, 72 ] ] }, { "id": "DS.d433.s1", "type": "", "text": [ "In this study we determined whether the UV light-reactive ATP analogues 2-azido ATP, ATP azidoanilide (ATP-AA) and 2', 3'-O-(4-benzoylbenzoyl)-ATP (BzATP) can be used to label the ATP binding site of P2X1 receptors." ], "offsets": [ [ 73, 288 ] ] }, { "id": "DS.d433.s2", "type": "", "text": [ "cross-linked to P2X1 receptors and this binding was reduced by co-incubation with ATP." ], "offsets": [ [ 289, 375 ] ] }, { "id": "DS.d433.s3", "type": "", "text": [ "These studies demonstrate that photo-reactive ATP analogues can be used to label P2X receptor and may prove useful in elucidating the ATP binding site at this novel class of ATP binding proteins." ], "offsets": [ [ 376, 571 ] ] } ]
[ { "id": "DS.d433.s0.e0", "type": "compound", "text": [ "ATP" ], "offsets": [ [ 20, 23 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5957" } ] }, { "id": "DS.d433.s0.e1", "type": "protein", "text": [ "P2X" ], "offsets": [ [ 58, 61 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P13900" }, { "db_name": "UniProt", "db_id": "P16604" } ] }, { "id": "DS.d433.s1.e0", "type": "compound", "text": [ "ATP" ], "offsets": [ [ 131, 134 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5957" } ] }, { "id": "DS.d433.s1.e1", "type": "compound", "text": [ "2-azido ATP" ], "offsets": [ [ 145, 156 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "123645" }, { "db_name": "PubChem", "db_id": "189791" } ] }, { "id": "DS.d433.s1.e2", "type": "compound", "text": [ "ATP" ], "offsets": [ [ 153, 156 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5957" } ] }, { "id": "DS.d433.s1.e3", "type": "compound", "text": [ "ATP" ], "offsets": [ [ 153, 156 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5957" } ] }, { "id": "DS.d433.s1.e4", "type": "compound", "text": [ "3'-O-(4-benzoylbenzoyl)-ATP" ], "offsets": [ [ 192, 219 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "115205" } ] }, { "id": "DS.d433.s1.e5", "type": "compound", "text": [ "BzATP" ], "offsets": [ [ 221, 226 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "115205" } ] }, { "id": "DS.d433.s1.e6", "type": "protein", "text": [ "P2X1" ], "offsets": [ [ 273, 277 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P47824" }, { "db_name": "UniProt", "db_id": "P51575" }, { "db_name": "UniProt", "db_id": "P51576" } ] }, { "id": "DS.d433.s2.e0", "type": "protein", "text": [ "P2X1" ], "offsets": [ [ 305, 309 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P47824" }, { "db_name": "UniProt", "db_id": "P51575" }, { "db_name": "UniProt", "db_id": "P51576" } ] }, { "id": "DS.d433.s2.e1", "type": "compound", "text": [ "ATP" ], "offsets": [ [ 371, 374 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5957" } ] }, { "id": "DS.d433.s3.e0", "type": "compound", "text": [ "ATP" ], "offsets": [ [ 422, 425 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5957" } ] }, { "id": "DS.d433.s3.e1", "type": "protein", "text": [ "P2X" ], "offsets": [ [ 457, 460 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P13900" }, { "db_name": "UniProt", "db_id": "P16604" } ] } ]
[]
[]
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DS.d434
18599154
[ { "id": "DS.d434.s0", "type": "", "text": [ "TGF-beta1 treatment for 72 h also induced EMT in the A549 cells and this transition led to resistance to gefitinib." ], "offsets": [ [ 0, 115 ] ] } ]
[ { "id": "DS.d434.s0.e0", "type": "protein", "text": [ "TGF-beta1" ], "offsets": [ [ 0, 9 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O19011" }, { "db_name": "UniProt", "db_id": "O93449" }, { "db_name": "UniProt", "db_id": "P01137" }, { "db_name": "UniProt", "db_id": "P04202" }, { "db_name": "UniProt", "db_id": "P07200" }, { "db_name": "UniProt", "db_id": "P09531" }, { "db_name": "UniProt", "db_id": "P09533" }, { "db_name": "UniProt", "db_id": "P16176" }, { "db_name": "UniProt", "db_id": "P17246" }, { "db_name": "UniProt", "db_id": "P18341" }, { "db_name": "UniProt", "db_id": "P50414" }, { "db_name": "UniProt", "db_id": "P54831" }, { "db_name": "UniProt", "db_id": "Q38HS2" }, { "db_name": "UniProt", "db_id": "Q9PTQ2" }, { "db_name": "UniProt", "db_id": "Q9Z1Y6" } ] }, { "id": "DS.d434.s0.e1", "type": "compound", "text": [ "gefitinib" ], "offsets": [ [ 105, 114 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "123631" } ] } ]
[]
[]
[ { "id": "DS.d434.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d434.s0.e1", "arg2_id": "DS.d434.s0.e0", "normalized": [] } ]
DS.d435
18599191
[ { "id": "DS.d435.s0", "type": "", "text": [ "Insulin-antagonistic effects of hormones, cytokines and excess metabolic substrates such as glucose and fatty acids may be exerted via common mechanisms involving for example reactive oxygen species (ROS) accumulation and associated inflammatory responses." ], "offsets": [ [ 0, 256 ] ] } ]
[ { "id": "DS.d435.s0.e0", "type": "protein", "text": [ "Insulin" ], "offsets": [ [ 0, 7 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01314" }, { "db_name": "UniProt", "db_id": "P01316" }, { "db_name": "UniProt", "db_id": "P01319" }, { "db_name": "UniProt", "db_id": "P01320" }, { "db_name": "UniProt", "db_id": "P01324" }, { "db_name": "UniProt", "db_id": "P01328" }, { "db_name": "UniProt", "db_id": "P01330" }, { "db_name": "UniProt", "db_id": "P01331" }, { "db_name": "UniProt", "db_id": "P01334" }, { "db_name": "UniProt", "db_id": "P01336" }, { "db_name": "UniProt", "db_id": "P01340" }, { "db_name": "UniProt", "db_id": "P07453" }, { "db_name": "UniProt", "db_id": "P09476" }, { "db_name": "UniProt", "db_id": "P09477" }, { "db_name": "UniProt", "db_id": "P0C236" }, { "db_name": "UniProt", "db_id": "P12703" }, { "db_name": "UniProt", "db_id": "P12704" }, { "db_name": "UniProt", "db_id": "P12708" }, { "db_name": "UniProt", "db_id": "P13190" }, { "db_name": "UniProt", "db_id": "P18109" }, { "db_name": "UniProt", "db_id": "P29335" }, { "db_name": "UniProt", "db_id": "P42633" }, { "db_name": "UniProt", "db_id": "P67968" }, { "db_name": "UniProt", "db_id": "P67969" }, { "db_name": "UniProt", "db_id": "P67971" }, { "db_name": "UniProt", "db_id": "P67973" }, { "db_name": "UniProt", "db_id": "P67974" }, { "db_name": "UniProt", "db_id": "P68243" }, { "db_name": "UniProt", "db_id": "P68245" }, { "db_name": "UniProt", "db_id": "P68987" }, { "db_name": "UniProt", "db_id": "P68988" }, { "db_name": "UniProt", "db_id": "P68989" }, { "db_name": "UniProt", "db_id": "P68990" }, { "db_name": "UniProt", "db_id": "P68991" }, { "db_name": "UniProt", "db_id": "P68992" }, { "db_name": "UniProt", "db_id": "P69046" }, { "db_name": "UniProt", "db_id": "P69047" }, { "db_name": "UniProt", "db_id": "P69048" }, { "db_name": "UniProt", "db_id": "P81423" }, { "db_name": "UniProt", "db_id": "P81881" }, { "db_name": "UniProt", "db_id": "Q9TQY7" } ] }, { "id": "DS.d435.s0.e1", "type": "compound", "text": [ "glucose" ], "offsets": [ [ 92, 99 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "206" }, { "db_name": "PubChem", "db_id": "5793" }, { "db_name": "PubChem", "db_id": "64689" }, { "db_name": "PubChem", "db_id": "79025" } ] } ]
[]
[]
[ { "id": "DS.d435.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d435.s0.e1", "arg2_id": "DS.d435.s0.e0", "normalized": [] } ]
DS.d436
18599210
[ { "id": "DS.d436.s0", "type": "", "text": [ "Optimization of decolorization of methylene blue (MB) dye by lignin peroxidase (LiP) enzyme produced by white-rot fungus Phanerochaete chrysosporium using sewage treatment plant (STP) sludge as a major substrate was carried out in the laboratory." ], "offsets": [ [ 0, 246 ] ] } ]
[ { "id": "DS.d436.s0.e0", "type": "compound", "text": [ "methylene blue" ], "offsets": [ [ 34, 48 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "4139" } ] }, { "id": "DS.d436.s0.e1", "type": "protein", "text": [ "lignin peroxidase" ], "offsets": [ [ 61, 78 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P06181" }, { "db_name": "UniProt", "db_id": "P11542" }, { "db_name": "UniProt", "db_id": "P11543" }, { "db_name": "UniProt", "db_id": "P20010" }, { "db_name": "UniProt", "db_id": "P20011" }, { "db_name": "UniProt", "db_id": "P20012" }, { "db_name": "UniProt", "db_id": "P20013" }, { "db_name": "UniProt", "db_id": "P21764" }, { "db_name": "UniProt", "db_id": "P31837" }, { "db_name": "UniProt", "db_id": "P31838" }, { "db_name": "UniProt", "db_id": "P49012" }, { "db_name": "UniProt", "db_id": "P50622" } ] } ]
[]
[]
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DS.d437
18600448
[ { "id": "DS.d437.s0", "type": "", "text": [ "Glycine release was potentiated by the activation of protein kinase C and diminished by increasing cyclic guanosine monophosphate levels with a phosphodiesterase inhibitor, zaprinast." ], "offsets": [ [ 0, 183 ] ] } ]
[ { "id": "DS.d437.s0.e0", "type": "compound", "text": [ "Glycine" ], "offsets": [ [ 0, 7 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "750" } ] }, { "id": "DS.d437.s0.e1", "type": "protein", "text": [ "protein kinase C" ], "offsets": [ [ 53, 69 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P13678" }, { "db_name": "UniProt", "db_id": "Q25378" } ] }, { "id": "DS.d437.s0.e2", "type": "compound", "text": [ "cyclic guanosine monophosphate" ], "offsets": [ [ 99, 129 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "24316" } ] }, { "id": "DS.d437.s0.e3", "type": "compound", "text": [ "zaprinast" ], "offsets": [ [ 173, 182 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5722" } ] } ]
[]
[]
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DS.d438
18600455
[ { "id": "DS.d438.s0", "type": "", "text": [ "Our study demonstrates that taurocholate causes evident damage to acinar cells, impairing both calcium homeostasis and secretory response to CCK." ], "offsets": [ [ 0, 145 ] ] } ]
[ { "id": "DS.d438.s0.e0", "type": "compound", "text": [ "taurocholate" ], "offsets": [ [ 28, 40 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6675" } ] }, { "id": "DS.d438.s0.e1", "type": "protein", "text": [ "CCK" ], "offsets": [ [ 141, 144 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O57312" }, { "db_name": "UniProt", "db_id": "O93464" }, { "db_name": "UniProt", "db_id": "P01355" }, { "db_name": "UniProt", "db_id": "P01356" }, { "db_name": "UniProt", "db_id": "P06307" }, { "db_name": "UniProt", "db_id": "P09240" }, { "db_name": "UniProt", "db_id": "P0C229" }, { "db_name": "UniProt", "db_id": "P23362" }, { "db_name": "UniProt", "db_id": "P41520" }, { "db_name": "UniProt", "db_id": "P50144" }, { "db_name": "UniProt", "db_id": "P50145" }, { "db_name": "UniProt", "db_id": "P68125" }, { "db_name": "UniProt", "db_id": "P68126" }, { "db_name": "UniProt", "db_id": "P80344" }, { "db_name": "UniProt", "db_id": "P80345" }, { "db_name": "UniProt", "db_id": "Q9PU29" }, { "db_name": "UniProt", "db_id": "Q9PU41" } ] } ]
[]
[]
[ { "id": "DS.d438.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d438.s0.e0", "arg2_id": "DS.d438.s0.e1", "normalized": [] } ]
DS.d439
18600456
[ { "id": "DS.d439.s0", "type": "", "text": [ "Enteric neuronal dopamine (DA) inhibits acetylcholine release and gastric motility; this has been thought to be mediated via neuronal dopamine-2 receptor (D2R)." ], "offsets": [ [ 0, 160 ] ] } ]
[ { "id": "DS.d439.s0.e0", "type": "compound", "text": [ "acetylcholine" ], "offsets": [ [ 40, 53 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "187" } ] }, { "id": "DS.d439.s0.e1", "type": "protein", "text": [ "D2R" ], "offsets": [ [ 155, 158 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q8IS44" } ] } ]
[]
[]
[ { "id": "DS.d439.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d439.s0.e0", "arg2_id": "DS.d439.s0.e1", "normalized": [] } ]
DS.d440
18600473
[ { "id": "DS.d440.s0", "type": "", "text": [ "As compared with parental B16 cells, the inhibitory effects of TGF-beta1 and activin A on melanin content were relative smaller in B16 F10 cells, a subline of B16 cells that contain more pigment." ], "offsets": [ [ 0, 195 ] ] } ]
[ { "id": "DS.d440.s0.e0", "type": "protein", "text": [ "TGF-beta1" ], "offsets": [ [ 63, 72 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O19011" }, { "db_name": "UniProt", "db_id": "O93449" }, { "db_name": "UniProt", "db_id": "P01137" }, { "db_name": "UniProt", "db_id": "P04202" }, { "db_name": "UniProt", "db_id": "P07200" }, { "db_name": "UniProt", "db_id": "P09531" }, { "db_name": "UniProt", "db_id": "P09533" }, { "db_name": "UniProt", "db_id": "P16176" }, { "db_name": "UniProt", "db_id": "P17246" }, { "db_name": "UniProt", "db_id": "P18341" }, { "db_name": "UniProt", "db_id": "P50414" }, { "db_name": "UniProt", "db_id": "P54831" }, { "db_name": "UniProt", "db_id": "Q38HS2" }, { "db_name": "UniProt", "db_id": "Q9PTQ2" }, { "db_name": "UniProt", "db_id": "Q9Z1Y6" } ] }, { "id": "DS.d440.s0.e1", "type": "compound", "text": [ "melanin" ], "offsets": [ [ 90, 97 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6325610" } ] } ]
[]
[]
[ { "id": "DS.d440.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d440.s0.e1", "arg2_id": "DS.d440.s0.e0", "normalized": [] } ]
DS.d441
18601937
[ { "id": "DS.d441.s0", "type": "", "text": [ "ATP-gated P2X receptors on excitatory nerve terminals onto interneurons initiate a form of asynchronous glutamate release." ], "offsets": [ [ 0, 122 ] ] }, { "id": "DS.d441.s1", "type": "", "text": [ "However asynchronous EPSCs were increased following synaptic depression and a component of these appeared to be initiated by endogenously released ATP acting on presynaptic P2X receptors." ], "offsets": [ [ 123, 310 ] ] }, { "id": "DS.d441.s2", "type": "", "text": [ "Unexpectedly, the data suggest P2X receptor activation initiates a form of asynchronous glutamate release, rather than detectably affecting the vesicles underlying action potential evoked release." ], "offsets": [ [ 311, 507 ] ] } ]
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[]
[]
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DS.d442
18601945
[ { "id": "DS.d442.s0", "type": "", "text": [ "The second enzyme of GSH synthesis, GSH synthase (GS) is also regulated in a coordinated manner as GCL subunits and its up-regulation can further enhance the capacity of the cell to synthesize GSH." ], "offsets": [ [ 0, 197 ] ] } ]
[ { "id": "DS.d442.s0.e0", "type": "compound", "text": [ "GSH" ], "offsets": [ [ 21, 24 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "124886" } ] }, { "id": "DS.d442.s0.e1", "type": "compound", "text": [ "GSH" ], "offsets": [ [ 36, 39 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "124886" } ] }, { "id": "DS.d442.s0.e2", "type": "protein", "text": [ "GCL" ], "offsets": [ [ 99, 102 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P28676" }, { "db_name": "UniProt", "db_id": "Q8NEA9" }, { "db_name": "UniProt", "db_id": "Q96IK5" } ] }, { "id": "DS.d442.s0.e3", "type": "compound", "text": [ "GSH" ], "offsets": [ [ 36, 39 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "124886" } ] } ]
[]
[]
[ { "id": "DS.d442.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d442.s0.e0", "arg2_id": "DS.d442.s0.e2", "normalized": [] } ]
DS.d443
18602447
[ { "id": "DS.d443.s0", "type": "", "text": [ "The rise in (Ca(2+))(i) elicited by hGH is associated with an enhanced insulin secretion, effects that are mediated mainly through the prolactin receptor." ], "offsets": [ [ 0, 154 ] ] }, { "id": "DS.d443.s1", "type": "", "text": [ "These mechanisms indicate that a rise in (Ca(2+))(i) elicited by activation of PRLR is JAK2-dependent and is associated with enhanced insulin secretion." ], "offsets": [ [ 155, 307 ] ] }, { "id": "DS.d443.s2", "type": "", "text": [ "In contrast, GH receptor-mediated increase in (Ca(2+))(i) is JAK2-independent and is dissociated from insulin secretion." ], "offsets": [ [ 308, 428 ] ] } ]
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"db_id": "P81423" }, { "db_name": "UniProt", "db_id": "P81881" }, { "db_name": "UniProt", "db_id": "Q9TQY7" } ] }, { "id": "DS.d443.s0.e2", "type": "protein", "text": [ "prolactin" ], "offsets": [ [ 135, 144 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P10765" }, { "db_name": "UniProt", "db_id": "P22393" }, { "db_name": "UniProt", "db_id": "P33089" }, { "db_name": "UniProt", "db_id": "P33090" }, { "db_name": "UniProt", "db_id": "P33091" }, { "db_name": "UniProt", "db_id": "P43001" } ] }, { "id": "DS.d443.s1.e0", "type": "compound", "text": [ "Ca(2" ], "offsets": [ [ 197, 201 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "271" } ] }, { "id": "DS.d443.s1.e1", "type": "protein", "text": [ "PRLR" ], "offsets": [ [ 234, 238 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O46561" }, { "db_name": "UniProt", "db_id": "P14787" }, { "db_name": "UniProt", "db_id": "P16471" }, { "db_name": "UniProt", "db_id": "Q04594" }, { "db_name": "UniProt", "db_id": "Q28172" }, { "db_name": "UniProt", "db_id": "Q28235" }, { "db_name": "UniProt", "db_id": "Q6JTA8" }, { "db_name": "UniProt", "db_id": "Q90374" }, { "db_name": "UniProt", "db_id": "Q91094" }, { "db_name": "UniProt", "db_id": "Q91513" } ] }, { "id": "DS.d443.s1.e2", "type": "protein", "text": [ "JAK2" ], "offsets": [ [ 242, 246 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O60674" } ] }, { "id": "DS.d443.s1.e3", "type": "protein", "text": [ "insulin" ], "offsets": [ [ 289, 296 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01314" }, { "db_name": "UniProt", "db_id": "P01316" }, { "db_name": "UniProt", "db_id": "P01319" }, { "db_name": "UniProt", "db_id": "P01320" }, { "db_name": "UniProt", "db_id": "P01324" }, { "db_name": "UniProt", "db_id": "P01328" }, { "db_name": "UniProt", "db_id": "P01330" }, { "db_name": "UniProt", "db_id": "P01331" }, { "db_name": "UniProt", "db_id": "P01334" }, { "db_name": "UniProt", "db_id": "P01336" }, { "db_name": "UniProt", "db_id": "P01340" }, { "db_name": "UniProt", "db_id": "P07453" }, { "db_name": "UniProt", "db_id": "P09476" }, { "db_name": "UniProt", "db_id": "P09477" }, { "db_name": "UniProt", "db_id": "P0C236" }, { "db_name": "UniProt", "db_id": "P12703" }, { "db_name": "UniProt", "db_id": "P12704" }, { "db_name": "UniProt", "db_id": "P12708" }, { "db_name": "UniProt", "db_id": "P13190" }, { "db_name": "UniProt", "db_id": "P18109" }, { "db_name": "UniProt", "db_id": "P29335" }, { "db_name": "UniProt", "db_id": "P42633" }, { "db_name": "UniProt", "db_id": "P67968" }, { "db_name": "UniProt", "db_id": "P67969" }, { "db_name": "UniProt", "db_id": "P67971" }, { "db_name": "UniProt", "db_id": "P67973" }, { "db_name": "UniProt", "db_id": "P67974" }, { "db_name": "UniProt", "db_id": "P68243" }, { "db_name": "UniProt", "db_id": "P68245" }, { "db_name": "UniProt", "db_id": "P68987" }, { "db_name": "UniProt", "db_id": "P68988" }, { "db_name": "UniProt", "db_id": "P68989" }, { "db_name": "UniProt", "db_id": "P68990" }, { "db_name": 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DS.d444
18602691
[ { "id": "DS.d444.s0", "type": "", "text": [ "SEMG I expression is upregulated by IL-4, IL-6 and 5-azacytidine." ], "offsets": [ [ 0, 65 ] ] } ]
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[]
[]
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DS.d445
18602794
[ { "id": "DS.d445.s0", "type": "", "text": [ "Trichostatin A down-regulates CYP19 transcript and protein levels in MCF-7 breast cancer cells." ], "offsets": [ [ 0, 95 ] ] } ]
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[]
[]
[ { "id": "DS.d445.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d445.s0.e0", "arg2_id": "DS.d445.s0.e1", "normalized": [] } ]
DS.d446
18602807
[ { "id": "DS.d446.s0", "type": "", "text": [ "Consumption of the trichothecene mycotoxin deoxynivalenol (DON) induces interleukin-6 (IL-6)-dependent IgA nephropathy (IgAN) in mice." ], "offsets": [ [ 0, 134 ] ] }, { "id": "DS.d446.s1", "type": "", "text": [ "The purpose of this study was to identify the signal transduction pathways by which DON up-regulates IL-6 in the peritoneal macrophage and how consumption of fish oil enriched with the n-3 PUFA docosahexaenoic acid (DHA) suppresses these processes." ], "offsets": [ [ 135, 383 ] ] } ]
[ { "id": "DS.d446.s0.e1", "type": "compound", "text": [ "deoxynivalenol" ], "offsets": [ [ 43, 57 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "40024" }, { "db_name": "PubChem", "db_id": "430147" }, { "db_name": "PubChem", "db_id": "442408" }, { "db_name": "PubChem", "db_id": "6321385" }, { "db_name": "PubChem", "db_id": "6432495" }, { "db_name": "PubChem", "db_id": "49868109" } ] }, { "id": "DS.d446.s0.e2", "type": "protein", "text": [ "interleukin-6" ], "offsets": [ [ 72, 85 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P41693" } ] }, { "id": "DS.d446.s0.e3", "type": "protein", "text": [ "IL-6" ], "offsets": [ [ 87, 91 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O35736" }, { "db_name": "UniProt", "db_id": "P05231" }, { "db_name": "UniProt", "db_id": "P08505" }, { "db_name": "UniProt", "db_id": "P20607" }, { "db_name": "UniProt", "db_id": "P26892" }, { "db_name": "UniProt", "db_id": "P26893" }, { "db_name": "UniProt", "db_id": "P29455" }, { "db_name": "UniProt", "db_id": "P41323" }, { "db_name": "UniProt", "db_id": "P41683" }, { "db_name": "UniProt", "db_id": "P41693" }, { "db_name": "UniProt", "db_id": "P46650" }, { "db_name": "UniProt", "db_id": "P51494" }, { "db_name": "UniProt", "db_id": "P79341" }, { "db_name": "UniProt", "db_id": "Q25BC2" }, { "db_name": "UniProt", "db_id": "Q28319" }, { "db_name": "UniProt", "db_id": "Q28747" }, { "db_name": "UniProt", "db_id": "Q28819" }, { "db_name": "UniProt", "db_id": "Q2MH06" }, { "db_name": "UniProt", "db_id": "Q5I6E3" }, { "db_name": "UniProt", "db_id": "Q6V919" }, { "db_name": "UniProt", "db_id": "Q865W7" }, { "db_name": "UniProt", "db_id": "Q865X6" }, { "db_name": "UniProt", "db_id": "Q8MKH0" }, { "db_name": "UniProt", "db_id": "Q95181" }, { "db_name": "UniProt", "db_id": "Q9MZR1" }, { "db_name": "UniProt", "db_id": "Q9XT80" } ] }, { "id": "DS.d446.s1.e0", "type": "protein", "text": [ "IL-6" ], "offsets": [ [ 236, 240 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O35736" }, { "db_name": "UniProt", "db_id": "P05231" }, { "db_name": "UniProt", "db_id": "P08505" }, { "db_name": "UniProt", "db_id": "P20607" }, { "db_name": "UniProt", "db_id": "P26892" }, { "db_name": "UniProt", "db_id": "P26893" }, { "db_name": "UniProt", "db_id": "P29455" }, { "db_name": "UniProt", "db_id": "P41323" }, { "db_name": "UniProt", "db_id": "P41683" }, { "db_name": "UniProt", "db_id": "P41693" }, { "db_name": "UniProt", "db_id": "P46650" }, { "db_name": "UniProt", "db_id": "P51494" }, { "db_name": "UniProt", "db_id": "P79341" }, { "db_name": "UniProt", "db_id": "Q25BC2" }, { "db_name": "UniProt", "db_id": "Q28319" }, { "db_name": "UniProt", "db_id": "Q28747" }, { "db_name": "UniProt", "db_id": "Q28819" }, { "db_name": "UniProt", "db_id": "Q2MH06" }, { "db_name": "UniProt", "db_id": "Q5I6E3" }, { "db_name": "UniProt", "db_id": "Q6V919" }, { "db_name": "UniProt", "db_id": "Q865W7" }, { "db_name": "UniProt", "db_id": "Q865X6" }, { "db_name": "UniProt", "db_id": "Q8MKH0" }, { "db_name": "UniProt", "db_id": "Q95181" }, { "db_name": "UniProt", "db_id": "Q9MZR1" }, { "db_name": "UniProt", "db_id": "Q9XT80" } ] }, { "id": "DS.d446.s1.e1", "type": "compound", "text": [ "docosahexaenoic acid" ], "offsets": [ [ 329, 349 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "445580" } ] } ]
[]
[]
[ { "id": "DS.d446.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d446.s0.e1", "arg2_id": "DS.d446.s0.e2", "normalized": [] }, { "id": "DS.d446.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d446.s0.e1", "arg2_id": "DS.d446.s0.e3", "normalized": [] }, { "id": "DS.d446.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d446.s1.e1", "arg2_id": "DS.d446.s1.e0", "normalized": [] } ]
DS.d448
18602814
[ { "id": "DS.d448.s0", "type": "", "text": [ "The aim of the present study was to determine the effects of niacin and chromium on HDL formation by investigating the changes in ABCA1 and ApoA-1 transcription in the human hepatoblastoma cell line (HepG2 cells)." ], "offsets": [ [ 0, 213 ] ] }, { "id": "DS.d448.s1", "type": "", "text": [ "Niacin and chromium cotreatment significantly induced the expression of peroxisome proliferator-activated receptor-alpha (PPARalpha) mRNA by approximately 1.3-1.8-fold." ], "offsets": [ [ 214, 382 ] ] }, { "id": "DS.d448.s2", "type": "", "text": [ "A combination of niacin and chromium chloride did not significantly increase (3+1 mM) but instead reduced (1+3 mM) ABCA1 gene expression." ], "offsets": [ [ 383, 520 ] ] }, { "id": "DS.d448.s3", "type": "", "text": [ "We hypothesize that the stimulation of ABCA1 gene expression causes an enhanced cholesterol efflux, perhaps mediated by PPARalpha pathway(s)." ], "offsets": [ [ 521, 662 ] ] } ]
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[]
[]
[ { "id": "DS.d448.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d448.s1.e1", "arg2_id": "DS.d448.s1.e2", "normalized": [] }, { "id": "DS.d448.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d448.s1.e1", "arg2_id": "DS.d448.s1.e3", "normalized": [] }, { "id": "DS.d448.s1.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d448.s1.e0", "arg2_id": "DS.d448.s1.e2", "normalized": [] }, { "id": "DS.d448.s1.i3", "type": "compound-protein-interaction", "arg1_id": "DS.d448.s1.e0", "arg2_id": "DS.d448.s1.e3", "normalized": [] }, { "id": "DS.d448.s2.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d448.s2.e0", "arg2_id": "DS.d448.s2.e2", "normalized": [] }, { "id": "DS.d448.s2.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d448.s2.e1", "arg2_id": "DS.d448.s2.e2", "normalized": [] }, { "id": "DS.d448.s3.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d448.s3.e1", "arg2_id": "DS.d448.s3.e0", "normalized": [] }, { "id": "DS.d448.s3.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d448.s3.e1", "arg2_id": "DS.d448.s3.e2", "normalized": [] } ]
DS.d450
18602823
[ { "id": "DS.d450.s0", "type": "", "text": [ "Sulforaphane inhibited cell proliferation with IC(50) values at 24 and 48 h of 12.5 and 7.5 muM doses, respectively, and decreased ERalpha protein expression at concentrations between 2.5 and 30 muM." ], "offsets": [ [ 0, 199 ] ] }, { "id": "DS.d450.s1", "type": "", "text": [ "30 muM, the SUL-induced suppression of ERalpha protein was reversed by preincubation with the proteasome inhibitor MG132 and was accompanied by an increase in protein levels of the 20S catalytic core subunit PSMB5." ], "offsets": [ [ 200, 414 ] ] } ]
[ { "id": "DS.d450.s0.e0", "type": "compound", "text": [ "Sulforaphane" ], "offsets": [ [ 0, 12 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5350" } ] }, { "id": "DS.d450.s0.e1", "type": "protein", "text": [ "ERalpha" ], "offsets": [ [ 131, 138 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O42132" }, { "db_name": "UniProt", "db_id": "P03372" }, { "db_name": "UniProt", "db_id": "P06211" }, { "db_name": "UniProt", "db_id": "P06212" }, { "db_name": "UniProt", "db_id": "P16058" }, { "db_name": "UniProt", "db_id": "P19785" }, { "db_name": "UniProt", "db_id": "P49884" }, { "db_name": "UniProt", "db_id": "P49885" }, { "db_name": "UniProt", "db_id": "P49886" }, { "db_name": "UniProt", "db_id": "P50240" }, { "db_name": "UniProt", "db_id": "P50241" }, { "db_name": "UniProt", "db_id": "P50242" }, { "db_name": "UniProt", "db_id": "P57717" }, { "db_name": "UniProt", "db_id": "P57753" }, { "db_name": "UniProt", "db_id": "P81559" }, { "db_name": "UniProt", "db_id": "Q29040" }, { "db_name": "UniProt", "db_id": "Q53AD2" }, { "db_name": "UniProt", "db_id": "Q91250" }, { "db_name": "UniProt", "db_id": "Q91424" }, { "db_name": "UniProt", "db_id": "Q9PVZ9" }, { "db_name": "UniProt", "db_id": "Q9QZJ5" }, { "db_name": "UniProt", "db_id": "Q9TV98" }, { "db_name": "UniProt", "db_id": "Q9YH33" }, { "db_name": "UniProt", "db_id": "Q9YHT3" }, { "db_name": "UniProt", "db_id": "Q9YHZ7" } ] }, { "id": "DS.d450.s1.e0", "type": "protein", "text": [ "ERalpha" ], "offsets": [ [ 239, 246 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O42132" }, { "db_name": "UniProt", "db_id": "P03372" }, { "db_name": "UniProt", "db_id": "P06211" }, { "db_name": "UniProt", "db_id": "P06212" }, { "db_name": "UniProt", "db_id": "P16058" }, { "db_name": "UniProt", "db_id": "P19785" }, { "db_name": "UniProt", "db_id": "P49884" }, { "db_name": "UniProt", "db_id": "P49885" }, { "db_name": "UniProt", "db_id": "P49886" }, { "db_name": "UniProt", "db_id": "P50240" }, { "db_name": "UniProt", "db_id": "P50241" }, { "db_name": "UniProt", "db_id": "P50242" }, { "db_name": "UniProt", "db_id": "P57717" }, { "db_name": "UniProt", "db_id": "P57753" }, { "db_name": "UniProt", "db_id": "P81559" }, { "db_name": "UniProt", "db_id": "Q29040" }, { "db_name": "UniProt", "db_id": "Q53AD2" }, { "db_name": "UniProt", "db_id": "Q91250" }, { "db_name": "UniProt", "db_id": "Q91424" }, { "db_name": "UniProt", "db_id": "Q9PVZ9" }, { "db_name": "UniProt", "db_id": "Q9QZJ5" }, { "db_name": "UniProt", "db_id": "Q9TV98" }, { "db_name": "UniProt", "db_id": "Q9YH33" }, { "db_name": "UniProt", "db_id": "Q9YHT3" }, { "db_name": "UniProt", "db_id": "Q9YHZ7" } ] }, { "id": "DS.d450.s1.e1", "type": "compound", "text": [ "MG132" ], "offsets": [ [ 315, 320 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "462382" } ] }, { "id": "DS.d450.s1.e2", "type": "protein", "text": [ "PSMB5" ], "offsets": [ [ 408, 413 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P28074" }, { "db_name": "UniProt", "db_id": "P34065" } ] } ]
[]
[]
[ { "id": "DS.d450.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d450.s0.e0", "arg2_id": "DS.d450.s0.e1", "normalized": [] }, { "id": "DS.d450.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d450.s1.e1", "arg2_id": "DS.d450.s1.e0", "normalized": [] } ]
DS.d452
18603252
[ { "id": "DS.d452.s0", "type": "", "text": [ "Of importance, treatment with ezetimibe significantly improved endothelial dysfunction as assessed by the vasodilator response to acetylcholine, accompanied by inhibition of interleukin-6 mRNA and an increase in endothelial nitric oxide synthase (eNOS) mRNA in the aorta." ], "offsets": [ [ 0, 271 ] ] } ]
[ { "id": "DS.d452.s0.e0", "type": "compound", "text": [ "ezetimibe" ], "offsets": [ [ 30, 39 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "150311" } ] }, { "id": "DS.d452.s0.e1", "type": "compound", "text": [ "acetylcholine" ], "offsets": [ [ 130, 143 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "187" } ] }, { "id": "DS.d452.s0.e2", "type": "protein", "text": [ "interleukin-6" ], "offsets": [ [ 174, 187 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P41693" } ] }, { "id": "DS.d452.s0.e3", "type": "protein", "text": [ "nitric oxide synthase" ], "offsets": [ [ 224, 245 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O61309" }, { "db_name": "UniProt", "db_id": "O61608" }, { "db_name": "UniProt", "db_id": "Q27571" }, { "db_name": "UniProt", "db_id": "Q9I9M2" } ] }, { "id": "DS.d452.s0.e4", "type": "protein", "text": [ "eNOS" ], "offsets": [ [ 247, 251 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P29473" }, { "db_name": "UniProt", "db_id": "P29474" }, { "db_name": "UniProt", "db_id": "P70313" }, { "db_name": "UniProt", "db_id": "P79209" }, { "db_name": "UniProt", "db_id": "P97270" }, { "db_name": "UniProt", "db_id": "Q28969" }, { "db_name": "UniProt", "db_id": "Q62600" } ] } ]
[]
[]
[ { "id": "DS.d452.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d452.s0.e0", "arg2_id": "DS.d452.s0.e4", "normalized": [] }, { "id": "DS.d452.s0.i3", "type": "compound-protein-interaction", "arg1_id": "DS.d452.s0.e0", "arg2_id": "DS.d452.s0.e2", "normalized": [] }, { "id": "DS.d452.s0.i5", "type": "compound-protein-interaction", "arg1_id": "DS.d452.s0.e0", "arg2_id": "DS.d452.s0.e3", "normalized": [] } ]
DS.d453
18603333
[ { "id": "DS.d453.s0", "type": "", "text": [ "A series of adamantane derivatives of thiazolyl-N-substituted amides were synthesized in a three-step reaction and tested for anti-inflammatory activity as well as lipoxygenase and cycloxygenase inhibitory actions." ], "offsets": [ [ 0, 214 ] ] } ]
[ { "id": "DS.d453.s0.e0", "type": "compound", "text": [ "adamantane" ], "offsets": [ [ 12, 22 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "9238" } ] }, { "id": "DS.d453.s0.e1", "type": "protein", "text": [ "lipoxygenase" ], "offsets": [ [ 164, 176 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P27481" }, { "db_name": "UniProt", "db_id": "P38414" } ] } ]
[]
[]
[]
DS.d454
18604600
[ { "id": "DS.d454.s0", "type": "", "text": [ "Dopamine D4 receptor involvement in the discriminative stimulus effects in rats of LSD, but not the phenethylamine hallucinogen DOI." ], "offsets": [ [ 0, 132 ] ] } ]
[ { "id": "DS.d454.s0.e0", "type": "protein", "text": [ "Dopamine D4 receptor" ], "offsets": [ [ 0, 20 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P21917" }, { "db_name": "UniProt", "db_id": "P30729" }, { "db_name": "UniProt", "db_id": "P51436" }, { "db_name": "UniProt", "db_id": "Q6TLJ0" } ] }, { "id": "DS.d454.s0.e1", "type": "compound", "text": [ "LSD" ], "offsets": [ [ 83, 86 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5761" } ] }, { "id": "DS.d454.s0.e2", "type": "compound", "text": [ "phenethylamine" ], "offsets": [ [ 100, 114 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1001" }, { "db_name": "PubChem", "db_id": "31016" } ] }, { "id": "DS.d454.s0.e4", "type": "compound", "text": [ "DOI" ], "offsets": [ [ 128, 131 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1229" }, { "db_name": "PubChem", "db_id": "6603801" }, { "db_name": "PubChem", "db_id": "9840090" } ] } ]
[]
[]
[ { "id": "DS.d454.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d454.s0.e1", "arg2_id": "DS.d454.s0.e0", "normalized": [] } ]
DS.d455
18606045
[ { "id": "DS.d455.s0", "type": "", "text": [ "Plasma levels of magnesium, zinc and carotenoids did not vary across quintiles, but weak negative correlations were observed with serum ferritin and transferrin saturation." ], "offsets": [ [ 0, 172 ] ] } ]
[ { "id": "DS.d455.s0.e0", "type": "compound", "text": [ "magnesium" ], "offsets": [ [ 17, 26 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5462224" } ] }, { "id": "DS.d455.s0.e1", "type": "protein", "text": [ "ferritin" ], "offsets": [ [ 136, 144 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q26061" } ] }, { "id": "DS.d455.s0.e2", "type": "protein", "text": [ "transferrin" ], "offsets": [ [ 149, 160 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P02787" }, { "db_name": "UniProt", "db_id": "P09571" }, { "db_name": "UniProt", "db_id": "P12346" }, { "db_name": "UniProt", "db_id": "P19134" }, { "db_name": "UniProt", "db_id": "P27425" }, { "db_name": "UniProt", "db_id": "Q29443" }, { "db_name": "UniProt", "db_id": "Q921I1" } ] } ]
[]
[]
[ { "id": "DS.d455.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d455.s0.e0", "arg2_id": "DS.d455.s0.e2", "normalized": [] }, { "id": "DS.d455.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d455.s0.e0", "arg2_id": "DS.d455.s0.e1", "normalized": [] } ]
DS.d456
18606396
[ { "id": "DS.d456.s0", "type": "", "text": [ "Two major groups of ligand-activated nuclear receptors/xenosensors evolved: the Ah receptor (activated by aryl hydrocarbons and drugs such as omeprazole) and type 2 steroid receptors such as PXR and CAR, activated by drugs such as rifampicin, carbamazepin and phenytoin." ], "offsets": [ [ 0, 270 ] ] } ]
[ { "id": "DS.d456.s0.e0", "type": "protein", "text": [ "Ah receptor" ], "offsets": [ [ 80, 91 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O02747" }, { "db_name": "UniProt", "db_id": "P30561" }, { "db_name": "UniProt", "db_id": "P35869" }, { "db_name": "UniProt", "db_id": "P41738" }, { "db_name": "UniProt", "db_id": "Q8R4S2" }, { "db_name": "UniProt", "db_id": "Q8R4S4" }, { "db_name": "UniProt", "db_id": "Q8R4S5" }, { "db_name": "UniProt", "db_id": "Q8R4S6" }, { "db_name": "UniProt", "db_id": "Q8R4S7" }, { "db_name": "UniProt", "db_id": "Q95LD9" } ] }, { "id": "DS.d456.s0.e1", "type": "compound", "text": [ "omeprazole" ], "offsets": [ [ 142, 152 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "4594" }, { "db_name": "PubChem", "db_id": "9579578" } ] }, { "id": "DS.d456.s0.e2", "type": "protein", "text": [ "PXR" ], "offsets": [ [ 191, 194 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O75469" }, { "db_name": "UniProt", "db_id": "Q8SQ01" } ] }, { "id": "DS.d456.s0.e3", "type": "compound", "text": [ "rifampicin" ], "offsets": [ [ 231, 241 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5381226" }, { "db_name": "PubChem", "db_id": "5388984" }, { "db_name": "PubChem", "db_id": "5458213" }, { "db_name": "PubChem", "db_id": "6243627" }, { "db_name": "PubChem", "db_id": "6842115" }, { "db_name": "PubChem", "db_id": "6913622" }, { "db_name": "PubChem", "db_id": "16043998" }, { "db_name": "PubChem", "db_id": "17753751" }, { "db_name": "PubChem", "db_id": "25141428" }, { "db_name": "PubChem", "db_id": "45356263" }, { "db_name": "PubChem", "db_id": "56947149" } ] }, { "id": "DS.d456.s0.e4", "type": "compound", "text": [ "phenytoin" ], "offsets": [ [ 260, 269 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1775" } ] } ]
[]
[]
[ { "id": "DS.d456.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d456.s0.e4", "arg2_id": "DS.d456.s0.e2", "normalized": [] }, { "id": "DS.d456.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d456.s0.e3", "arg2_id": "DS.d456.s0.e2", "normalized": [] }, { "id": "DS.d456.s0.i5", "type": "compound-protein-interaction", "arg1_id": "DS.d456.s0.e1", "arg2_id": "DS.d456.s0.e0", "normalized": [] } ]
DS.d457
18607531
[ { "id": "DS.d457.s0", "type": "", "text": [ "The structure-activity relationship between oxycoumarin derivatives showing inhibitory effects on iNOS in mouse macrophage RAW264.7 cells." ], "offsets": [ [ 0, 138 ] ] }, { "id": "DS.d457.s1", "type": "", "text": [ "We have investigated the structure-activity relationship between 63 natural oxycoumarin derivatives and their effects on the expression of inducible-nitric oxide synthase (iNOS) induced by lipopolysaccharide." ], "offsets": [ [ 139, 347 ] ] } ]
[ { "id": "DS.d457.s0.e0", "type": "compound", "text": [ "oxycoumarin" ], "offsets": [ [ 44, 55 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5281426" } ] }, { "id": "DS.d457.s0.e1", "type": "protein", "text": [ "iNOS" ], "offsets": [ [ 98, 102 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O19114" }, { "db_name": "UniProt", "db_id": "O46660" }, { "db_name": "UniProt", "db_id": "O54705" }, { "db_name": "UniProt", "db_id": "O62699" }, { "db_name": "UniProt", "db_id": "P29477" }, { "db_name": "UniProt", "db_id": "P35228" }, { "db_name": "UniProt", "db_id": "P79290" }, { "db_name": "UniProt", "db_id": "Q06518" }, { "db_name": "UniProt", "db_id": "Q27995" }, { "db_name": "UniProt", "db_id": "Q28314" }, { "db_name": "UniProt", "db_id": "Q90703" }, { "db_name": "UniProt", "db_id": "Q92037" }, { "db_name": "UniProt", "db_id": "Q92091" } ] }, { "id": "DS.d457.s1.e0", "type": "compound", "text": [ "oxycoumarin" ], "offsets": [ [ 215, 226 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5281426" } ] }, { "id": "DS.d457.s1.e1", "type": "protein", "text": [ "nitric oxide synthase" ], "offsets": [ [ 288, 309 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O61309" }, { "db_name": "UniProt", "db_id": "O61608" }, { "db_name": "UniProt", "db_id": "Q27571" }, { "db_name": "UniProt", "db_id": "Q9I9M2" } ] }, { "id": "DS.d457.s1.e2", "type": "protein", "text": [ "iNOS" ], "offsets": [ [ 311, 315 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O19114" }, { "db_name": "UniProt", "db_id": "O46660" }, { "db_name": "UniProt", "db_id": "O54705" }, { "db_name": "UniProt", "db_id": "O62699" }, { "db_name": "UniProt", "db_id": "P29477" }, { "db_name": "UniProt", "db_id": "P35228" }, { "db_name": "UniProt", "db_id": "P79290" }, { "db_name": "UniProt", "db_id": "Q06518" }, { "db_name": "UniProt", "db_id": "Q27995" }, { "db_name": "UniProt", "db_id": "Q28314" }, { "db_name": "UniProt", "db_id": "Q90703" }, { "db_name": "UniProt", "db_id": "Q92037" }, { "db_name": "UniProt", "db_id": "Q92091" } ] }, { "id": "DS.d457.s1.e3", "type": "compound", "text": [ "lipopolysaccharide" ], "offsets": [ [ 328, 346 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "11970143" } ] } ]
[]
[]
[ { "id": "DS.d457.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d457.s0.e0", "arg2_id": "DS.d457.s0.e1", "normalized": [] }, { "id": "DS.d457.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d457.s1.e3", "arg2_id": "DS.d457.s1.e2", "normalized": [] }, { "id": "DS.d457.s1.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d457.s1.e3", "arg2_id": "DS.d457.s1.e1", "normalized": [] } ]
DS.d458
18607542
[ { "id": "DS.d458.s0", "type": "", "text": [ "Inhibition of protein synthesis by imexon reduces HIF-1alpha expression in normoxic and hypoxic pancreatic cancer cells." ], "offsets": [ [ 0, 120 ] ] }, { "id": "DS.d458.s1", "type": "", "text": [ "Western blot analyses of imexon-treated cells demonstrated that imexon reduces HIF-1alpha protein levels in both normoxic and hypoxic conditions in a time- and concentration-dependant fashion." ], "offsets": [ [ 121, 313 ] ] }, { "id": "DS.d458.s2", "type": "", "text": [ "Gemcitabine did not similarly affect HIF-1alpha levels." ], "offsets": [ [ 314, 369 ] ] }, { "id": "DS.d458.s3", "type": "", "text": [ "Concurrently, the half-life of existing HIF-1alpha protein was increased by imexon, in association with a marked inhibition of chymotryptic activity in the 20S proteasome." ], "offsets": [ [ 370, 541 ] ] }, { "id": "DS.d458.s4", "type": "", "text": [ "The inhibition of HIF-1alpha translation was not specific, rather it was part of a general decrease in protein translation caused by imexon." ], "offsets": [ [ 542, 682 ] ] } ]
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[]
[]
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DS.d459
18607689
[ { "id": "DS.d459.s0", "type": "", "text": [ "To determine whether a regimen of aspirin pretreatment, bivalirudin during the procedure and clopidogrel (600 mg) immediately after percutaneous coronary intervention (PCI) was associated with platelet activation during and shortly after (1 and 2 h) PCI, we characterized platelet function in 10 patients with the use of flow cytometry in the absence of agonist and in response to thrombin (10 nM), ADP (1 microM), the collagen-mimetic convulxin (5 ng/ml), and platelet activating factor (10 nM)." ], "offsets": [ [ 0, 496 ] ] } ]
[ { "id": "DS.d459.s0.e0", "type": "compound", "text": [ "aspirin" ], "offsets": [ [ 34, 41 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2244" } ] }, { "id": "DS.d459.s0.e1", "type": "compound", "text": [ "bivalirudin" ], "offsets": [ [ 56, 67 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "16129704" } ] }, { "id": "DS.d459.s0.e2", "type": "compound", "text": [ "clopidogrel" ], "offsets": [ [ 93, 104 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2806" }, { "db_name": "PubChem", "db_id": "60606" } ] }, { "id": "DS.d459.s0.e3", "type": "protein", "text": [ "thrombin" ], "offsets": [ [ 381, 389 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P84122" } ] }, { "id": "DS.d459.s0.e4", "type": "compound", "text": [ "platelet activating factor" ], "offsets": [ [ 461, 487 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "108157" } ] } ]
[]
[]
[]
DS.d460
18607722
[ { "id": "DS.d460.s0", "type": "", "text": [ "Brainstem concentrations of cholesterol are not influenced by genetic ablation of the low-density lipoprotein receptor." ], "offsets": [ [ 0, 119 ] ] }, { "id": "DS.d460.s1", "type": "", "text": [ "The low-density lipoprotein receptor (LDLr) mediates the uptake of LDL particles enriched with cholesterol, into several tissues." ], "offsets": [ [ 120, 249 ] ] } ]
[ { "id": "DS.d460.s0.e0", "type": "compound", "text": [ "cholesterol" ], "offsets": [ [ 28, 39 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "304" }, { "db_name": "PubChem", "db_id": "5997" }, { "db_name": "PubChem", "db_id": "6432564" }, { "db_name": "PubChem", "db_id": "11025495" } ] }, { "id": "DS.d460.s0.e1", "type": "protein", "text": [ "low-density lipoprotein receptor" ], "offsets": [ [ 86, 118 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01131" }, { "db_name": "UniProt", "db_id": "P20063" }, { "db_name": "UniProt", "db_id": "Q28832" } ] }, { "id": "DS.d460.s1.e0", "type": "protein", "text": [ "low-density lipoprotein receptor" ], "offsets": [ [ 124, 156 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01131" }, { "db_name": "UniProt", "db_id": "P20063" }, { "db_name": "UniProt", "db_id": "Q28832" } ] }, { "id": "DS.d460.s1.e1", "type": "compound", "text": [ "cholesterol" ], "offsets": [ [ 215, 226 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "304" }, { "db_name": "PubChem", "db_id": "5997" }, { "db_name": "PubChem", "db_id": "6432564" }, { "db_name": "PubChem", "db_id": "11025495" } ] } ]
[]
[]
[ { "id": "DS.d460.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d460.s1.e1", "arg2_id": "DS.d460.s1.e0", "normalized": [] } ]
DS.d461
18607918
[ { "id": "DS.d461.s0", "type": "", "text": [ "Under the condition of delayed intervention (30 days after deafening) following gentamicin+ furosemide deafening in rats, we conclude that chronic intracochlear electrical stimulation (ES) and continuous intracochlear administration of brain-derived neurotrophic factor (BDNF) enhance spiral ganglion cell (SGC) body and peripheral process survival and improve auditory sensitivity." ], "offsets": [ [ 0, 382 ] ] } ]
[ { "id": "DS.d461.s0.e0", "type": "compound", "text": [ "gentamicin" ], "offsets": [ [ 80, 90 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "3467" } ] }, { "id": "DS.d461.s0.e1", "type": "compound", "text": [ "furosemide" ], "offsets": [ [ 92, 102 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "3440" } ] }, { "id": "DS.d461.s0.e2", "type": "protein", "text": [ "brain-derived neurotrophic factor" ], "offsets": [ [ 236, 269 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P25430" }, { "db_name": "UniProt", "db_id": "P25431" }, { "db_name": "UniProt", "db_id": "P25432" }, { "db_name": "UniProt", "db_id": "Q06225" } ] }, { "id": "DS.d461.s0.e3", "type": "protein", "text": [ "BDNF" ], "offsets": [ [ 271, 275 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O18752" }, { "db_name": "UniProt", "db_id": "O18753" }, { "db_name": "UniProt", "db_id": "O18755" }, { "db_name": "UniProt", "db_id": "O70183" }, { "db_name": "UniProt", "db_id": "O97759" }, { "db_name": "UniProt", "db_id": "P14082" }, { "db_name": "UniProt", "db_id": "P21237" }, { "db_name": "UniProt", "db_id": "P23363" }, { "db_name": "UniProt", "db_id": "P23560" }, { "db_name": "UniProt", "db_id": "P25429" }, { "db_name": "UniProt", "db_id": "P25430" }, { "db_name": "UniProt", "db_id": "P25431" }, { "db_name": "UniProt", "db_id": "P25432" }, { "db_name": "UniProt", "db_id": "Q02193" }, { "db_name": "UniProt", "db_id": "Q06225" }, { "db_name": "UniProt", "db_id": "Q3SAT7" }, { "db_name": "UniProt", "db_id": "Q4L0Y3" }, { "db_name": "UniProt", "db_id": "Q5IS78" }, { "db_name": "UniProt", "db_id": "Q6LCI5" }, { "db_name": "UniProt", "db_id": "Q7YRB4" }, { "db_name": "UniProt", "db_id": "Q90322" }, { "db_name": "UniProt", "db_id": "Q95106" }, { "db_name": "UniProt", "db_id": "Q9TST3" } ] } ]
[]
[]
[]
DS.d463
18608753
[ { "id": "DS.d463.s0", "type": "", "text": [ "For this purpose, human erythrocyte glutathione reductase was initially purified 2139-fold in a yield of 29% by using 2', 5'-ADP Sepharose 4B affinity gel and Sephadex G-200 gel filtration chromatography." ], "offsets": [ [ 0, 204 ] ] } ]
[ { "id": "DS.d463.s0.e0", "type": "protein", "text": [ "glutathione reductase" ], "offsets": [ [ 36, 57 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O15770" }, { "db_name": "UniProt", "db_id": "P06715" }, { "db_name": "UniProt", "db_id": "P11804" }, { "db_name": "UniProt", "db_id": "P23189" }, { "db_name": "UniProt", "db_id": "P41921" }, { "db_name": "UniProt", "db_id": "P43783" }, { "db_name": "UniProt", "db_id": "P48638" }, { "db_name": "UniProt", "db_id": "P48639" }, { "db_name": "UniProt", "db_id": "P70619" }, { "db_name": "UniProt", "db_id": "P78965" }, { "db_name": "UniProt", "db_id": "Q60151" }, { "db_name": "UniProt", "db_id": "Q6BPI1" }, { "db_name": "UniProt", "db_id": "Q6C5H4" }, { "db_name": "UniProt", "db_id": "Q6FRV2" }, { "db_name": "UniProt", "db_id": "Q6HA23" }, { "db_name": "UniProt", "db_id": "Q74ZK4" }, { "db_name": "UniProt", "db_id": "Q873E8" }, { "db_name": "UniProt", "db_id": "Q94655" } ] }, { "id": "DS.d463.s0.e1", "type": "compound", "text": [ "Sepharose" ], "offsets": [ [ 129, 138 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "11966311" } ] } ]
[]
[]
[]
DS.d464
18608754
[ { "id": "DS.d464.s0", "type": "", "text": [ "The enzyme deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) catalyses the hydrolysis of dUTP to dUMP and PPi thus controlling the incorporation of uracil into DNA genomes." ], "offsets": [ [ 0, 181 ] ] }, { "id": "DS.d464.s1", "type": "", "text": [ "In the present study we perform a kinetic analysis of Campylobacter dUTPase using the continuous spectrophotometric method and show that the enzyme is highly specific for deoxyuridine nucleotides." ], "offsets": [ [ 182, 378 ] ] } ]
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[]
[]
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DS.d465
18608755
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[]
[]
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DS.d468
18608766
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DS.d469
18608782
[ { "id": "DS.d469.s0", "type": "", "text": [ "Adenosine deaminase (ADA), an enzyme involved in purine metabolism, catalyzes the hydrolytic breakdown of adenosine into inosine and free ammonia." ], "offsets": [ [ 0, 146 ] ] } ]
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DS.d470
18609042
[ { "id": "DS.d470.s0", "type": "", "text": [ "Diastolic function and BNP changes during exercise predict oxygen consumption in chronic heart failure patients." ], "offsets": [ [ 0, 112 ] ] } ]
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DS.d471
18609294
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[]
[]
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DS.d472
18609433
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[]
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DS.d474
18612599
[ { "id": "DS.d474.s0", "type": "", "text": [ "GCK is expressed in the rat DVC, where mRNA is localized to neurons that exhibit electrophysiological sensitivity to glucose imbalance." ], "offsets": [ [ 0, 135 ] ] } ]
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[]
[]
[]
DS.d476
18612775
[ { "id": "DS.d476.s0", "type": "", "text": [ "Indoleamine 2,3-dioxygenase (IDO) catalyzes the first and rate-limiting step of Kynurenine pathway along the major route of Tryptophan catabolism." ], "offsets": [ [ 0, 146 ] ] } ]
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[]
[]
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DS.d477
18612777
[ { "id": "DS.d477.s0", "type": "", "text": [ "Type I transglutaminase (TG1), an enzyme that catalyzes the formation of epsilon-(gamma-glutamyl) lysine bonds, is the key protein responsible for generation of the crosslinks." ], "offsets": [ [ 0, 176 ] ] } ]
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[]
[]
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DS.d478
18612811
[ { "id": "DS.d478.s0", "type": "", "text": [ "Myc-oncogene inactivating effect by proline rich polypeptide (PRP-1) in chondrosarcoma JJ012 cells." ], "offsets": [ [ 0, 99 ] ] } ]
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[]
[]
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DS.d479
18612819
[ { "id": "DS.d479.s0", "type": "", "text": [ "Like PSC, DSL6A cells secrete less ET-1 when cultured with bosentan." ], "offsets": [ [ 0, 68 ] ] } ]
[ { "id": "DS.d479.s0.e0", "type": "protein", "text": [ "ET-1" ], "offsets": [ [ 35, 39 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P05305" }, { "db_name": "UniProt", "db_id": "P09558" }, { "db_name": "UniProt", "db_id": "P13206" }, { "db_name": "UniProt", "db_id": "P17322" }, { "db_name": "UniProt", "db_id": "P22387" }, { "db_name": "UniProt", "db_id": "P22388" }, { "db_name": "UniProt", "db_id": "P29560" }, { "db_name": "UniProt", "db_id": "P97740" }, { "db_name": "UniProt", "db_id": "Q28469" }, { "db_name": "UniProt", "db_id": "Q5NRP9" }, { "db_name": "UniProt", "db_id": "Q5NRQ1" }, { "db_name": "UniProt", "db_id": "Q9BG76" } ] }, { "id": "DS.d479.s0.e1", "type": "compound", "text": [ "bosentan" ], "offsets": [ [ 59, 67 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "104865" } ] } ]
[]
[]
[ { "id": "DS.d479.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d479.s0.e1", "arg2_id": "DS.d479.s0.e0", "normalized": [] } ]
DS.d480
18612824
[ { "id": "DS.d480.s0", "type": "", "text": [ "Caspase inhibition with z-VAD was unable to prevent AIF localization to the nucleus and subsequently unable to prevent cell death." ], "offsets": [ [ 0, 130 ] ] } ]
[ { "id": "DS.d480.s0.e0", "type": "compound", "text": [ "VAD" ], "offsets": [ [ 26, 29 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5289545" } ] }, { "id": "DS.d480.s0.e1", "type": "protein", "text": [ "AIF" ], "offsets": [ [ 52, 55 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O95831" } ] } ]
[]
[]
[]
DS.d481
18614168
[ { "id": "DS.d481.s0", "type": "", "text": [ "Purinergic receptor agonists ATP and UTP selectively activate certain Src family tyrosine kinases and stimulate Na,K-ATPase activity." ], "offsets": [ [ 0, 133 ] ] } ]
[ { "id": "DS.d481.s0.e0", "type": "compound", "text": [ "ATP" ], "offsets": [ [ 29, 32 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5957" } ] }, { "id": "DS.d481.s0.e1", "type": "compound", "text": [ "UTP" ], "offsets": [ [ 37, 40 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6133" } ] }, { "id": "DS.d481.s0.e2", "type": "protein", "text": [ "Src" ], "offsets": [ [ 70, 73 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P05480" }, { "db_name": "UniProt", "db_id": "Q9WUD9" } ] } ]
[]
[]
[ { "id": "DS.d481.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d481.s0.e0", "arg2_id": "DS.d481.s0.e2", "normalized": [] }, { "id": "DS.d481.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d481.s0.e1", "arg2_id": "DS.d481.s0.e2", "normalized": [] } ]
DS.d482
18615010
[ { "id": "DS.d482.s0", "type": "", "text": [ "Early deprivation led to decreases in hippocampal growth-associated protein-43 (GAP-43) mRNA, serotonin 1A receptor (5-HT(1A)R) mRNA and binding ((3H)WAY100635), and to increased vesicular GABA transporter mRNA." ], "offsets": [ [ 0, 211 ] ] } ]
[ { "id": "DS.d482.s0.e0", "type": "protein", "text": [ "growth-associated protein-43" ], "offsets": [ [ 50, 78 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P06836" }, { "db_name": "UniProt", "db_id": "P06837" }, { "db_name": "UniProt", "db_id": "P07936" }, { "db_name": "UniProt", "db_id": "P17677" }, { "db_name": "UniProt", "db_id": "P17691" }, { "db_name": "UniProt", "db_id": "P35001" }, { "db_name": "UniProt", "db_id": "P55860" }, { "db_name": "UniProt", "db_id": "Q5IS67" }, { "db_name": "UniProt", "db_id": "Q5NVP7" }, { "db_name": "UniProt", "db_id": "Q6S9D9" }, { "db_name": "UniProt", "db_id": "Q95K78" }, { "db_name": "UniProt", "db_id": "Q98987" } ] }, { "id": "DS.d482.s0.e1", "type": "protein", "text": [ "GAP" ], "offsets": [ [ 80, 83 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P09851" }, { "db_name": "UniProt", "db_id": "P20936" }, { "db_name": "UniProt", "db_id": "P50904" }, { "db_name": "UniProt", "db_id": "P74851" }, { "db_name": "UniProt", "db_id": "P74873" }, { "db_name": "UniProt", "db_id": "Q5PEA9" }, { "db_name": "UniProt", "db_id": "Q92211" }, { "db_name": "UniProt", "db_id": "Q92263" } ] }, { "id": "DS.d482.s0.e2", "type": "compound", "text": [ "3H)WAY100635" ], "offsets": [ [ 147, 159 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5684" } ] }, { "id": "DS.d482.s0.e3", "type": "protein", "text": [ "vesicular GABA transporter" ], "offsets": [ [ 179, 205 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O35458" }, { "db_name": "UniProt", "db_id": "O35633" }, { "db_name": "UniProt", "db_id": "P34579" }, { "db_name": "UniProt", "db_id": "Q95KE2" }, { "db_name": "UniProt", "db_id": "Q9H598" } ] } ]
[]
[]
[]
DS.d483
18615011
[ { "id": "DS.d483.s0", "type": "", "text": [ "We measured the ability to increase GABA in eight healthy subjects by comparing the binding of ((11)C) flumazenil, a positron emission tomography (PET) radiotracer specific for the benzodiazepine (BDZ) site, at baseline and in the presence of an acute elevation in GABA levels through the blockade of the GABA membrane transporter (GAT1)." ], "offsets": [ [ 0, 338 ] ] }, { "id": "DS.d483.s1", "type": "", "text": [ "GAT1 blockade resulted in significant increases in mean (+/-SD) ((11)C) flumazenil-binding potential (BP(ND)) over baseline in brain regions representing the major functional domains of the cerebral cortex: association cortex+15.2+/-20.2% (p=0.05), sensory cortex+13.5+/-15.5% (p=0.03) and limbic (medial temporal lobe, MTL)+16.4+/-20.2% (p=0.03)." ], "offsets": [ [ 339, 686 ] ] } ]
[ { "id": "DS.d483.s0.e0", "type": "compound", "text": [ "flumazenil" ], "offsets": [ [ 103, 113 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "3373" } ] }, { "id": "DS.d483.s0.e1", "type": "protein", "text": [ "GAT1" ], "offsets": [ [ 332, 336 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P30531" }, { "db_name": "UniProt", "db_id": "P36148" }, { "db_name": "UniProt", "db_id": "P43574" } ] }, { "id": "DS.d483.s1.e0", "type": "protein", "text": [ "GAT1" ], "offsets": [ [ 339, 343 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P30531" }, { "db_name": "UniProt", "db_id": "P36148" }, { "db_name": "UniProt", "db_id": "P43574" } ] }, { "id": "DS.d483.s1.e1", "type": "compound", "text": [ "flumazenil" ], "offsets": [ [ 411, 421 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "3373" } ] } ]
[]
[]
[ { "id": "DS.d483.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d483.s1.e1", "arg2_id": "DS.d483.s1.e0", "normalized": [] } ]
DS.d484
18615280
[ { "id": "DS.d484.s0", "type": "", "text": [ "alpha-Glucosidase inhibitory activity of cyanidin-3-galactoside and synergistic effect with acarbose." ], "offsets": [ [ 0, 101 ] ] }, { "id": "DS.d484.s1", "type": "", "text": [ "Cyanidin-3-galactoside, a natural anthocyanin, was investigated for its alpha-glucosidase inhibitory activity." ], "offsets": [ [ 102, 212 ] ] } ]
[ { "id": "DS.d484.s0.e0", "type": "protein", "text": [ "alpha-Glucosidase" ], "offsets": [ [ 0, 17 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O33830" }, { "db_name": "UniProt", "db_id": "O43451" }, { "db_name": "UniProt", "db_id": "O59645" }, { "db_name": "UniProt", "db_id": "P21517" }, { "db_name": "UniProt", "db_id": "P43473" }, { "db_name": "UniProt", "db_id": "Q02751" } ] }, { "id": "DS.d484.s0.e1", "type": "compound", "text": [ "cyanidin-3-galactoside" ], "offsets": [ [ 41, 63 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "44256700" } ] }, { "id": "DS.d484.s0.e2", "type": "compound", "text": [ "acarbose" ], "offsets": [ [ 92, 100 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "41774" }, { "db_name": "PubChem", "db_id": "441184" }, { "db_name": "PubChem", "db_id": "444254" }, { "db_name": "PubChem", "db_id": "445421" }, { "db_name": "PubChem", "db_id": "4432690" } ] }, { "id": "DS.d484.s1.e0", "type": "compound", "text": [ "Cyanidin-3-galactoside" ], "offsets": [ [ 102, 124 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "44256700" } ] }, { "id": "DS.d484.s1.e1", "type": "compound", "text": [ "anthocyanin" ], "offsets": [ [ 136, 147 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "145858" } ] }, { "id": "DS.d484.s1.e2", "type": "protein", "text": [ "alpha-glucosidase" ], "offsets": [ [ 174, 191 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O33830" }, { "db_name": "UniProt", "db_id": "O43451" }, { "db_name": "UniProt", "db_id": "O59645" }, { "db_name": "UniProt", "db_id": "P21517" }, { "db_name": "UniProt", "db_id": "P43473" }, { "db_name": "UniProt", "db_id": "Q02751" } ] } ]
[]
[]
[ { "id": "DS.d484.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d484.s0.e1", "arg2_id": "DS.d484.s0.e0", "normalized": [] }, { "id": "DS.d484.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d484.s0.e2", "arg2_id": "DS.d484.s0.e0", "normalized": [] } ]
DS.d486
18615705
[ { "id": "DS.d486.s0", "type": "", "text": [ "The susceptibilities to three organophosphate (OP) insecticides (malathion, chlorpyrifos, and phoxim), responses to three metabolic synergists (triphenyl phosphate (TPP), piperonyl butoxide (PBO), and diethyl maleate (DEM)), activities of major detoxification enzymes (general esterases (ESTs), glutathione S-transferases (GSTs), and cytochrome P450 monooxygenases (P450s)), and sensitivity of the target enzyme acetylcholinesterase (AChE) were compared between a laboratory-susceptible strain (LS) and a field-resistant population (FR) of the oriental migratory locust, Locusta migratoria manilensis (Meyen)." ], "offsets": [ [ 0, 609 ] ] }, { "id": "DS.d486.s1", "type": "", "text": [ "All these results clearly indicated that the observed malathion resistance in the FR was conferred by multiple mechanisms, including increased detoxification by ESTs and GSTs, and increased activity and reduced sensitivity of AChE to OP inhibition." ], "offsets": [ [ 610, 858 ] ] } ]
[ { "id": "DS.d486.s0.e0", "type": "compound", "text": [ "malathion" ], "offsets": [ [ 65, 74 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "4004" } ] }, { "id": "DS.d486.s0.e1", "type": "compound", "text": [ "chlorpyrifos" ], "offsets": [ [ 76, 88 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2730" } ] }, { "id": "DS.d486.s0.e2", "type": "compound", "text": [ "phoxim" ], "offsets": [ [ 94, 100 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "9570290" } ] }, { "id": "DS.d486.s0.e3", "type": "compound", "text": [ "triphenyl phosphate" ], "offsets": [ [ 144, 163 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "8289" } ] }, { "id": "DS.d486.s0.e4", "type": "compound", "text": [ "piperonyl butoxide" ], "offsets": [ [ 171, 189 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5794" } ] }, { "id": "DS.d486.s0.e5", "type": "compound", "text": [ "diethyl maleate" ], "offsets": [ [ 201, 216 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5271566" } ] }, { "id": "DS.d486.s0.e6", "type": "protein", "text": [ "esterases" ], "offsets": [ [ 277, 286 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P16397" }, { "db_name": "UniProt", "db_id": "P18773" } ] }, { "id": "DS.d486.s0.e7", "type": "protein", "text": [ "glutathione S-transferases" ], "offsets": [ [ 295, 321 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O04437" }, { "db_name": "UniProt", "db_id": "O18598" }, { "db_name": "UniProt", "db_id": "P0A9D2" }, { "db_name": "UniProt", "db_id": "P0A9D3" }, { "db_name": "UniProt", "db_id": "P30116" }, { "db_name": "UniProt", "db_id": "P44521" }, { "db_name": "UniProt", "db_id": "P46088" }, { "db_name": "UniProt", "db_id": "P46419" }, { "db_name": "UniProt", "db_id": "P46423" }, { "db_name": "UniProt", "db_id": "P46426" }, { "db_name": "UniProt", "db_id": "P46428" }, { "db_name": "UniProt", "db_id": "P46437" }, { "db_name": "UniProt", "db_id": "P48438" }, { "db_name": "UniProt", "db_id": "P80894" }, { "db_name": "UniProt", "db_id": "P81065" }, { "db_name": "UniProt", "db_id": "P82996" }, { "db_name": "UniProt", "db_id": "P82997" }, { "db_name": "UniProt", "db_id": "P82998" }, { "db_name": "UniProt", "db_id": "P82999" }, { "db_name": "UniProt", "db_id": "P83000" }, { "db_name": "UniProt", "db_id": "P83001" }, { "db_name": "UniProt", "db_id": "P83246" }, { "db_name": "UniProt", "db_id": "Q04522" }, { "db_name": "UniProt", "db_id": "Q08392" }, { "db_name": "UniProt", "db_id": "Q08393" }, { "db_name": "UniProt", "db_id": "Q0ZS46" }, { "db_name": "UniProt", "db_id": "Q7REH6" }, { "db_name": "UniProt", "db_id": "Q8ILQ7" }, { "db_name": "UniProt", "db_id": "Q8MU52" }, { "db_name": "UniProt", "db_id": "Q96324" } ] }, { "id": "DS.d486.s0.e8", "type": "protein", "text": [ "GSTs" ], "offsets": [ [ 323, 327 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P20432" }, { "db_name": "UniProt", "db_id": "P30104" }, { "db_name": "UniProt", "db_id": "P30106" }, { "db_name": "UniProt", "db_id": "P30107" }, { "db_name": "UniProt", "db_id": "P30108" }, { "db_name": "UniProt", "db_id": "Q04522" }, { "db_name": "UniProt", "db_id": "Q0ZS46" }, { "db_name": "UniProt", "db_id": "Q7REH6" }, { "db_name": "UniProt", "db_id": "Q8ILQ7" }, { "db_name": "UniProt", "db_id": "Q8MU52" } ] }, { "id": "DS.d486.s0.e9", "type": "protein", "text": [ "cytochrome P450" ], "offsets": [ [ 334, 349 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O08469" } ] }, { "id": "DS.d486.s0.e10", "type": "protein", "text": [ "acetylcholinesterase" ], "offsets": [ [ 412, 432 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q867X2" }, { "db_name": "UniProt", "db_id": "Q867X3" }, { "db_name": "UniProt", "db_id": "Q86GC9" }, { "db_name": "UniProt", "db_id": "Q92081" } ] }, { "id": "DS.d486.s0.e11", "type": "protein", "text": [ "AChE" ], "offsets": [ [ 434, 438 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O42275" }, { "db_name": "UniProt", "db_id": "O62763" }, { "db_name": "UniProt", "db_id": "P04058" }, { "db_name": "UniProt", "db_id": "P07140" }, { "db_name": "UniProt", "db_id": "P07692" }, { "db_name": "UniProt", "db_id": "P21836" }, { "db_name": "UniProt", "db_id": "P22303" }, { "db_name": "UniProt", "db_id": "P23795" }, { "db_name": "UniProt", "db_id": "P36196" }, { "db_name": "UniProt", "db_id": "P37136" }, { "db_name": "UniProt", "db_id": "P56161" }, { "db_name": "UniProt", "db_id": "Q27677" }, { "db_name": "UniProt", "db_id": "Q29499" }, { "db_name": "UniProt", "db_id": "Q867X2" }, { "db_name": "UniProt", "db_id": "Q867X3" }, { "db_name": "UniProt", "db_id": "Q869C3" }, { "db_name": "UniProt", "db_id": "Q86GC8" }, { "db_name": "UniProt", "db_id": "Q86GC9" }, { "db_name": "UniProt", "db_id": "Q92035" }, { "db_name": "UniProt", "db_id": "Q92081" }, { "db_name": "UniProt", "db_id": "Q9DDE3" } ] }, { "id": "DS.d486.s1.e0", "type": "compound", "text": [ "malathion" ], "offsets": [ [ 664, 673 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "4004" } ] }, { "id": "DS.d486.s1.e1", "type": "protein", "text": [ "GSTs" ], "offsets": [ [ 780, 784 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P20432" }, { "db_name": "UniProt", "db_id": "P30104" }, { "db_name": "UniProt", "db_id": "P30106" }, { "db_name": "UniProt", "db_id": "P30107" }, { "db_name": "UniProt", "db_id": "P30108" }, { "db_name": "UniProt", "db_id": "Q04522" }, { "db_name": "UniProt", "db_id": "Q0ZS46" }, { "db_name": "UniProt", "db_id": "Q7REH6" }, { "db_name": "UniProt", "db_id": "Q8ILQ7" }, { "db_name": "UniProt", "db_id": "Q8MU52" } ] }, { "id": "DS.d486.s1.e2", "type": "protein", "text": [ "AChE" ], "offsets": [ [ 836, 840 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O42275" }, { "db_name": "UniProt", "db_id": "O62763" }, { "db_name": "UniProt", "db_id": "P04058" }, { "db_name": "UniProt", "db_id": "P07140" }, { "db_name": "UniProt", "db_id": "P07692" }, { "db_name": "UniProt", "db_id": "P21836" }, { "db_name": "UniProt", "db_id": "P22303" }, { "db_name": "UniProt", "db_id": "P23795" }, { "db_name": "UniProt", "db_id": "P36196" }, { "db_name": "UniProt", "db_id": "P37136" }, { "db_name": "UniProt", "db_id": "P56161" }, { "db_name": "UniProt", "db_id": "Q27677" }, { "db_name": "UniProt", "db_id": "Q29499" }, { "db_name": "UniProt", "db_id": "Q867X2" }, { "db_name": "UniProt", "db_id": "Q867X3" }, { "db_name": "UniProt", "db_id": "Q869C3" }, { "db_name": "UniProt", "db_id": "Q86GC8" }, { "db_name": "UniProt", "db_id": "Q86GC9" }, { "db_name": "UniProt", "db_id": "Q92035" }, { "db_name": "UniProt", "db_id": "Q92081" }, { "db_name": "UniProt", "db_id": "Q9DDE3" } ] } ]
[]
[]
[ { "id": "DS.d486.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d486.s1.e0", "arg2_id": "DS.d486.s1.e1", "normalized": [] }, { "id": "DS.d486.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d486.s1.e0", "arg2_id": "DS.d486.s1.e2", "normalized": [] } ]
DS.d487
18615707
[ { "id": "DS.d487.s0", "type": "", "text": [ "Lysozymes act as crucial bacteriolytic enzymes in insect immune system by hydrolyzing the beta (1-->4) bonds between N-acetylglucosamine and N-acetylmuramic acid in the peptidoglycan of prokaryotic cell walls." ], "offsets": [ [ 0, 212 ] ] } ]
[ { "id": "DS.d487.s0.e0", "type": "protein", "text": [ "Lysozymes" ], "offsets": [ [ 0, 9 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O64362" }, { "db_name": "UniProt", "db_id": "O80288" }, { "db_name": "UniProt", "db_id": "O80292" }, { "db_name": "UniProt", "db_id": "P00720" }, { "db_name": "UniProt", "db_id": "P03706" }, { "db_name": "UniProt", "db_id": "P07540" }, { "db_name": "UniProt", "db_id": "P09963" }, { "db_name": "UniProt", "db_id": "P10439" }, { "db_name": "UniProt", "db_id": "P11187" }, { "db_name": "UniProt", "db_id": "P13656" }, { "db_name": "UniProt", "db_id": "P15057" }, { "db_name": "UniProt", "db_id": "P19385" }, { "db_name": "UniProt", "db_id": "P19386" }, { "db_name": "UniProt", "db_id": "P21270" }, { "db_name": "UniProt", "db_id": "P23472" }, { "db_name": "UniProt", "db_id": "P23473" }, { "db_name": "UniProt", "db_id": "P27359" }, { "db_name": "UniProt", "db_id": "P33486" }, { "db_name": "UniProt", "db_id": "P37715" }, { "db_name": "UniProt", "db_id": "P39046" }, { "db_name": "UniProt", "db_id": "P51771" }, { "db_name": "UniProt", "db_id": "P62692" }, { "db_name": "UniProt", "db_id": "P62693" }, { "db_name": "UniProt", "db_id": "P68920" }, { "db_name": "UniProt", "db_id": "P68921" }, { "db_name": "UniProt", "db_id": "P81241" }, { "db_name": "UniProt", "db_id": "P82174" }, { "db_name": "UniProt", "db_id": "P82175" }, { "db_name": "UniProt", "db_id": "P83673" }, { "db_name": "UniProt", "db_id": "Q27650" }, { "db_name": "UniProt", "db_id": "Q37875" }, { "db_name": "UniProt", "db_id": "Q37896" }, { "db_name": "UniProt", "db_id": "Q48603" }, { "db_name": "UniProt", "db_id": "Q7SID7" }, { "db_name": "UniProt", "db_id": "Q9CIT4" }, { "db_name": "UniProt", "db_id": "Q9T1X2" }, { "db_name": "UniProt", "db_id": "Q9ZXB7" } ] }, { "id": "DS.d487.s0.e1", "type": "compound", "text": [ "N-acetylglucosamine" ], "offsets": [ [ 120, 139 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "24139" } ] }, { "id": "DS.d487.s0.e2", "type": "compound", "text": [ "N-acetylmuramic acid" ], "offsets": [ [ 144, 164 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "440822" }, { "db_name": "PubChem", "db_id": "542212" }, { "db_name": "PubChem", "db_id": "5462244" }, { "db_name": "PubChem", "db_id": "6323218" } ] }, { "id": "DS.d487.s0.e3", "type": "compound", "text": [ "peptidoglycan" ], "offsets": [ [ 172, 185 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "9816401" } ] } ]
[]
[]
[ { "id": "DS.d487.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d487.s0.e1", "arg2_id": "DS.d487.s0.e0", "normalized": [] }, { "id": "DS.d487.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d487.s0.e2", "arg2_id": "DS.d487.s0.e0", "normalized": [] }, { "id": "DS.d487.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d487.s0.e3", "arg2_id": "DS.d487.s0.e0", "normalized": [] } ]
DS.d488
18615734
[ { "id": "DS.d488.s0", "type": "", "text": [ "These mRNAs no longer encode the pleckstrin homology (PH) domain of collybistin, which we now show binds phosphatidylinositol-3-phosphate (PI3P/PtdIns-3-P), a phosphoinositide with an emerging role in membrane trafficking and signal transduction, rather than phosphatidylinositol 3,4,5-trisphosphate (PIP3/PtdIns-3,4,5-P) as previously suggested in the \" membrane activation model\" of gephyrin clustering." ], "offsets": [ [ 0, 405 ] ] } ]
[ { "id": "DS.d488.s0.e0", "type": "protein", "text": [ "pleckstrin" ], "offsets": [ [ 33, 43 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P08567" }, { "db_name": "UniProt", "db_id": "Q4KM33" }, { "db_name": "UniProt", "db_id": "Q6Q308" }, { "db_name": "UniProt", "db_id": "Q9JHK5" } ] }, { "id": "DS.d488.s0.e1", "type": "protein", "text": [ "collybistin" ], "offsets": [ [ 68, 79 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O43307" }, { "db_name": "UniProt", "db_id": "Q3UTH8" }, { "db_name": "UniProt", "db_id": "Q58DL7" }, { "db_name": "UniProt", "db_id": "Q5RDK0" }, { "db_name": "UniProt", "db_id": "Q9QX73" } ] }, { "id": "DS.d488.s0.e2", "type": "compound", "text": [ "phosphatidylinositol-3-phosphate" ], "offsets": [ [ 105, 137 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6857403" }, { "db_name": "PubChem", "db_id": "9776841" } ] }, { "id": "DS.d488.s0.e3", "type": "compound", "text": [ "PtdIns-3-P" ], "offsets": [ [ 144, 154 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "643964" }, { "db_name": "PubChem", "db_id": "24755494" } ] }, { "id": "DS.d488.s0.e4", "type": "compound", "text": [ "phosphoinositide" ], "offsets": [ [ 159, 175 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "16738692" } ] }, { "id": "DS.d488.s0.e5", "type": "compound", "text": [ "phosphatidylinositol 3,4,5-trisphosphate" ], "offsets": [ [ 259, 299 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "643963" } ] }, { "id": "DS.d488.s0.e6", "type": "compound", "text": [ "PtdIns-3,4,5-P" ], "offsets": [ [ 306, 320 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "643963" } ] }, { "id": "DS.d488.s0.e7", "type": "protein", "text": [ "gephyrin" ], "offsets": [ [ 385, 393 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q03555" }, { "db_name": "UniProt", "db_id": "Q9NQX3" } ] } ]
[]
[]
[ { "id": "DS.d488.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d488.s0.e2", "arg2_id": "DS.d488.s0.e0", "normalized": [] }, { "id": "DS.d488.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d488.s0.e4", "arg2_id": "DS.d488.s0.e1", "normalized": [] }, { "id": "DS.d488.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d488.s0.e3", "arg2_id": "DS.d488.s0.e1", "normalized": [] }, { "id": "DS.d488.s0.i3", "type": "compound-protein-interaction", "arg1_id": "DS.d488.s0.e5", "arg2_id": "DS.d488.s0.e1", "normalized": [] }, { "id": "DS.d488.s0.i4", "type": "compound-protein-interaction", "arg1_id": "DS.d488.s0.e5", "arg2_id": "DS.d488.s0.e0", "normalized": [] }, { "id": "DS.d488.s0.i5", "type": "compound-protein-interaction", "arg1_id": "DS.d488.s0.e6", "arg2_id": "DS.d488.s0.e1", "normalized": [] }, { "id": "DS.d488.s0.i6", "type": "compound-protein-interaction", "arg1_id": "DS.d488.s0.e3", "arg2_id": "DS.d488.s0.e0", "normalized": [] }, { "id": "DS.d488.s0.i7", "type": "compound-protein-interaction", "arg1_id": "DS.d488.s0.e6", "arg2_id": "DS.d488.s0.e0", "normalized": [] }, { "id": "DS.d488.s0.i9", "type": "compound-protein-interaction", "arg1_id": "DS.d488.s0.e2", "arg2_id": "DS.d488.s0.e1", "normalized": [] }, { "id": "DS.d488.s0.i10", "type": "compound-protein-interaction", "arg1_id": "DS.d488.s0.e4", "arg2_id": "DS.d488.s0.e0", "normalized": [] } ]
DS.d489
18616717
[ { "id": "DS.d489.s0", "type": "", "text": [ "We investigated whether several different inflammatory markers including C-reactive protein (CRP) and fibrinogen and white blood cells (WBCs) count, are associated with maximal oxygen consumption (VO(2 max)) in women with polycystic ovary syndrome (PCOS)." ], "offsets": [ [ 0, 255 ] ] } ]
[ { "id": "DS.d489.s0.e0", "type": "protein", "text": [ "CRP" ], "offsets": [ [ 93, 96 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O19062" }, { "db_name": "UniProt", "db_id": "P02741" }, { "db_name": "UniProt", "db_id": "P02742" }, { "db_name": "UniProt", "db_id": "P08462" }, { "db_name": "UniProt", "db_id": "P18151" }, { "db_name": "UniProt", "db_id": "P21291" }, { "db_name": "UniProt", "db_id": "P41964" }, { "db_name": "UniProt", "db_id": "P47875" }, { "db_name": "UniProt", "db_id": "P49254" }, { "db_name": "UniProt", "db_id": "P49262" }, { "db_name": "UniProt", "db_id": "P52753" }, { "db_name": "UniProt", "db_id": "P67966" }, { "db_name": "UniProt", "db_id": "P67967" }, { "db_name": "UniProt", "db_id": "P97315" }, { "db_name": "UniProt", "db_id": "Q07203" } ] }, { "id": "DS.d489.s0.e1", "type": "protein", "text": [ "fibrinogen" ], "offsets": [ [ 102, 112 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P22775" }, { "db_name": "UniProt", "db_id": "P81070" } ] }, { "id": "DS.d489.s0.e2", "type": "compound", "text": [ "oxygen" ], "offsets": [ [ 177, 183 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "977" } ] } ]
[]
[]
[]
DS.d491
18617682
[ { "id": "DS.d491.s0", "type": "", "text": [ "CSE activated the MMP-1 promoter, and this induction was prevented by PD98059 blockade of ERK1/2 phosphorylation." ], "offsets": [ [ 0, 113 ] ] }, { "id": "DS.d491.s1", "type": "", "text": [ "Cotransfection, mithramycin, and electrophoretic mobility shift assay studies identified activating and repressive roles for Sp1 and PEA3 transcription factors, respectively." ], "offsets": [ [ 114, 288 ] ] } ]
[ { "id": "DS.d491.s0.e0", "type": "protein", "text": [ "MMP-1" ], "offsets": [ [ 18, 23 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P03956" }, { "db_name": "UniProt", "db_id": "P13943" }, { "db_name": "UniProt", "db_id": "P21692" }, { "db_name": "UniProt", "db_id": "P28053" }, { "db_name": "UniProt", "db_id": "P81563" }, { "db_name": "UniProt", "db_id": "Q11133" }, { "db_name": "UniProt", "db_id": "Q9XSZ5" } ] }, { "id": "DS.d491.s0.e1", "type": "compound", "text": [ "PD98059" ], "offsets": [ [ 70, 77 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "4713" } ] }, { "id": "DS.d491.s0.e2", "type": "protein", "text": [ "ERK1" ], "offsets": [ [ 90, 94 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P27361" }, { "db_name": "UniProt", "db_id": "P28869" }, { "db_name": "UniProt", "db_id": "P42525" }, { "db_name": "UniProt", "db_id": "Q07176" } ] }, { "id": "DS.d491.s1.e0", "type": "compound", "text": [ "mithramycin" ], "offsets": [ [ 130, 141 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "29051" }, { "db_name": "PubChem", "db_id": "163659" }, { "db_name": "PubChem", "db_id": "230076" }, { "db_name": "PubChem", "db_id": "457831" }, { "db_name": "PubChem", "db_id": "6326719" } ] }, { "id": "DS.d491.s1.e1", "type": "protein", "text": [ "Sp1" ], "offsets": [ [ 239, 242 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O14300" }, { "db_name": "UniProt", "db_id": "O89090" }, { "db_name": "UniProt", "db_id": "P17379" }, { "db_name": "UniProt", "db_id": "Q01714" }, { "db_name": "UniProt", "db_id": "Q85439" }, { "db_name": "UniProt", "db_id": "Q85449" }, { "db_name": "UniProt", "db_id": "Q85451" } ] } ]
[]
[]
[ { "id": "DS.d491.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d491.s0.e1", "arg2_id": "DS.d491.s0.e2", "normalized": [] }, { "id": "DS.d491.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d491.s0.e1", "arg2_id": "DS.d491.s0.e0", "normalized": [] } ]
DS.d492
18617751
[ { "id": "DS.d492.s0", "type": "", "text": [ "We have previously demonstrated that iloprost, a stable prostacyclin (PGI (2)) analogue, induces angiogenesis in vivo, through a vascular endothelial growth factor (VEGF)-dependent mechanism." ], "offsets": [ [ 0, 191 ] ] }, { "id": "DS.d492.s1", "type": "", "text": [ "In this study, we demonstrate that iloprost-induced angiogenesis and VEGF upregulation are modulated by peroxisome proliferator-activated receptor-alpha (PPARalpha), a ligand-inducible transcription factor that belongs to the nuclear hormone receptor superfamily and plays multiple biological activities in the vascular system." ], "offsets": [ [ 192, 519 ] ] }, { "id": "DS.d492.s2", "type": "", "text": [ "In contrast, iloprost induces a robust angiogenic response in wild-type mice, along with local upregulation of VEGF." ], "offsets": [ [ 520, 636 ] ] }, { "id": "DS.d492.s3", "type": "", "text": [ "Importantly, mice lacking the PPARalpha gene exhibit a normal angiogenic response to VEGF, indicating that the absence of PPARalpha does not result in a general impairment of angiogenesis, but specifically affects the ability of iloprost to induce angiogenesis." ], "offsets": [ [ 637, 898 ] ] } ]
[ { "id": "DS.d492.s0.e0", "type": "compound", "text": [ "iloprost" ], "offsets": [ [ 37, 45 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5311181" }, { "db_name": "PubChem", "db_id": "6435378" }, { "db_name": "PubChem", "db_id": "6443959" }, { "db_name": "PubChem", "db_id": "53394043" }, { "db_name": "PubChem", "db_id": "53486260" } ] }, { "id": "DS.d492.s0.e1", "type": "compound", "text": [ "prostacyclin" ], "offsets": [ [ 56, 68 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5280427" }, { "db_name": "PubChem", "db_id": "5282411" }, { "db_name": "PubChem", "db_id": "6434194" } ] }, { "id": "DS.d492.s0.e2", "type": "protein", "text": [ "VEGF" ], "offsets": [ [ 165, 169 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P15691" }, { "db_name": "UniProt", "db_id": "P15692" }, { "db_name": "UniProt", "db_id": "P26617" }, { "db_name": "UniProt", "db_id": "P49151" }, { "db_name": "UniProt", "db_id": "P50412" }, { "db_name": "UniProt", "db_id": "P67964" }, { "db_name": "UniProt", "db_id": "P67965" }, { "db_name": "UniProt", "db_id": "Q99PS1" }, { "db_name": "UniProt", "db_id": "Q9GKR0" }, { "db_name": "UniProt", "db_id": "Q9MYV3" } ] }, { "id": "DS.d492.s1.e0", "type": "compound", "text": [ "iloprost" ], "offsets": [ [ 227, 235 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5311181" }, { "db_name": "PubChem", "db_id": "6435378" }, { "db_name": "PubChem", "db_id": "6443959" }, { "db_name": "PubChem", "db_id": "53394043" }, { "db_name": "PubChem", "db_id": "53486260" } ] }, { "id": "DS.d492.s1.e1", "type": "protein", "text": [ "VEGF" ], "offsets": [ [ 261, 265 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P15691" }, { "db_name": "UniProt", "db_id": "P15692" }, { "db_name": "UniProt", "db_id": "P26617" }, { "db_name": "UniProt", "db_id": "P49151" }, { "db_name": "UniProt", "db_id": "P50412" }, { "db_name": "UniProt", "db_id": "P67964" }, { "db_name": "UniProt", "db_id": "P67965" }, { "db_name": "UniProt", "db_id": "Q99PS1" }, { "db_name": "UniProt", "db_id": "Q9GKR0" }, { "db_name": "UniProt", "db_id": "Q9MYV3" } ] }, { "id": "DS.d492.s1.e2", "type": "protein", "text": [ "peroxisome proliferator-activated receptor-alpha" ], "offsets": [ [ 296, 344 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O35507" }, { "db_name": "UniProt", "db_id": "P23204" }, { "db_name": "UniProt", "db_id": "P37230" }, { "db_name": "UniProt", "db_id": "P37232" }, { "db_name": "UniProt", "db_id": "Q07869" }, { "db_name": "UniProt", "db_id": "Q8HYL6" }, { "db_name": "UniProt", "db_id": "Q95N78" } ] }, { "id": "DS.d492.s1.e3", "type": "protein", "text": [ "PPARalpha" ], "offsets": [ [ 346, 355 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O35507" }, { "db_name": "UniProt", "db_id": "P23204" }, { "db_name": "UniProt", "db_id": "P37230" }, { "db_name": "UniProt", "db_id": "P37232" }, { "db_name": "UniProt", "db_id": "Q07869" }, { "db_name": "UniProt", "db_id": "Q8HYL6" }, { "db_name": "UniProt", "db_id": "Q95N78" } ] }, { "id": "DS.d492.s2.e0", "type": "compound", "text": [ "iloprost" ], "offsets": [ [ 533, 541 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5311181" }, { "db_name": "PubChem", "db_id": "6435378" }, { "db_name": "PubChem", "db_id": "6443959" }, { "db_name": "PubChem", "db_id": "53394043" }, { "db_name": "PubChem", "db_id": "53486260" } ] }, { "id": "DS.d492.s2.e1", "type": "protein", "text": [ "VEGF" ], "offsets": [ [ 631, 635 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P15691" }, { "db_name": "UniProt", "db_id": "P15692" }, { "db_name": "UniProt", "db_id": "P26617" }, { "db_name": "UniProt", "db_id": "P49151" }, { "db_name": "UniProt", "db_id": "P50412" }, { "db_name": "UniProt", "db_id": "P67964" }, { "db_name": "UniProt", "db_id": "P67965" }, { "db_name": "UniProt", "db_id": "Q99PS1" }, { "db_name": "UniProt", "db_id": "Q9GKR0" }, { "db_name": "UniProt", "db_id": "Q9MYV3" } ] }, { "id": "DS.d492.s3.e0", "type": "protein", "text": [ "VEGF" ], "offsets": [ [ 722, 726 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P15691" }, { "db_name": "UniProt", "db_id": "P15692" }, { "db_name": "UniProt", "db_id": "P26617" }, { "db_name": "UniProt", "db_id": "P49151" }, { "db_name": "UniProt", "db_id": "P50412" }, { "db_name": "UniProt", "db_id": "P67964" }, { "db_name": "UniProt", "db_id": "P67965" }, { "db_name": "UniProt", "db_id": "Q99PS1" }, { "db_name": "UniProt", "db_id": "Q9GKR0" }, { "db_name": "UniProt", "db_id": "Q9MYV3" } ] }, { "id": "DS.d492.s3.e1", "type": "compound", "text": [ "iloprost" ], "offsets": [ [ 866, 874 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5311181" }, { "db_name": "PubChem", "db_id": "6435378" }, { "db_name": "PubChem", "db_id": "6443959" }, { "db_name": "PubChem", "db_id": "53394043" }, { "db_name": "PubChem", "db_id": "53486260" } ] } ]
[]
[]
[ { "id": "DS.d492.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d492.s0.e0", "arg2_id": "DS.d492.s0.e2", "normalized": [] }, { "id": "DS.d492.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d492.s1.e0", "arg2_id": "DS.d492.s1.e1", "normalized": [] }, { "id": "DS.d492.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d492.s1.e0", "arg2_id": "DS.d492.s1.e3", "normalized": [] }, { "id": "DS.d492.s1.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d492.s1.e0", "arg2_id": "DS.d492.s1.e2", "normalized": [] }, { "id": "DS.d492.s2.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d492.s2.e0", "arg2_id": "DS.d492.s2.e1", "normalized": [] }, { "id": "DS.d492.s3.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d492.s3.e1", "arg2_id": "DS.d492.s3.e0", "normalized": [] } ]
DS.d493
18618086
[ { "id": "DS.d493.s1", "type": "", "text": [ "The proportion of APP molecules that are directed to the novel cleavage pathway is regulated by the ratio of free cholesterol and cholesteryl esters in cells." ], "offsets": [ [ 0, 158 ] ] } ]
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[]
[]
[ { "id": "DS.d493.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d493.s1.e1", "arg2_id": "DS.d493.s1.e0", "normalized": [] } ]
DS.d494
18618240
[ { "id": "DS.d494.s0", "type": "", "text": [ "In the hormone receptor-positive breast cancer cell line T47-D expression of hCAR and its soluble isoforms was increased by treatment with estradiol and tamoxifen." ], "offsets": [ [ 0, 163 ] ] } ]
[ { "id": "DS.d494.s0.e0", "type": "protein", "text": [ "hCAR" ], "offsets": [ [ 77, 81 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P78310" } ] }, { "id": "DS.d494.s0.e1", "type": "compound", "text": [ "estradiol" ], "offsets": [ [ 139, 148 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5757" } ] }, { "id": "DS.d494.s0.e2", "type": "compound", "text": [ "tamoxifen" ], "offsets": [ [ 153, 162 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2733526" } ] } ]
[]
[]
[ { "id": "DS.d494.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d494.s0.e2", "arg2_id": "DS.d494.s0.e0", "normalized": [] }, { "id": "DS.d494.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d494.s0.e1", "arg2_id": "DS.d494.s0.e0", "normalized": [] } ]
DS.d495
18618241
[ { "id": "DS.d495.s0", "type": "", "text": [ "In contrast to the behavior in aqueous solution, lactose binding in DMSO resulted in an increase of the lectin's radius of gyration from 49+/-1 to 55.5+/-1 A." ], "offsets": [ [ 0, 158 ] ] } ]
[ { "id": "DS.d495.s0.e0", "type": "compound", "text": [ "DMSO" ], "offsets": [ [ 68, 72 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "679" } ] }, { "id": "DS.d495.s0.e1", "type": "protein", "text": [ "lectin" ], "offsets": [ [ 104, 110 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P02871" }, { "db_name": "UniProt", "db_id": "P02873" }, { "db_name": "UniProt", "db_id": "P02874" }, { "db_name": "UniProt", "db_id": "P02875" }, { "db_name": "UniProt", "db_id": "P07386" }, { "db_name": "UniProt", "db_id": "P16108" }, { "db_name": "UniProt", "db_id": "P16349" }, { "db_name": "UniProt", "db_id": "P16351" }, { "db_name": "UniProt", "db_id": "P16352" }, { "db_name": "UniProt", "db_id": "P33888" }, { "db_name": "UniProt", "db_id": "P38662" }, { "db_name": "UniProt", "db_id": "P42088" }, { "db_name": "UniProt", "db_id": "P83410" }, { "db_name": "UniProt", "db_id": "P83511" }, { "db_name": "UniProt", "db_id": "P84987" }, { "db_name": "UniProt", "db_id": "Q41114" } ] } ]
[]
[]
[ { "id": "DS.d495.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d495.s0.e0", "arg2_id": "DS.d495.s0.e1", "normalized": [] } ]
DS.d496
18618243
[ { "id": "DS.d496.s0", "type": "", "text": [ "Tumor necrosis factor-alpha (TNF-alpha) levels were also investigated in rat serum, but there was no statistically significant difference between the TNF-alpha levels of the caffeine-treated rats groups and the control rats." ], "offsets": [ [ 0, 224 ] ] }, { "id": "DS.d496.s1", "type": "", "text": [ "Our study indicates that brain arginase activity decreases after caffeine administration at doses of 30 mg/kg and 100 mg/kg." ], "offsets": [ [ 225, 349 ] ] } ]
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"P51435" }, { "db_name": "UniProt", "db_id": "P51742" }, { "db_name": "UniProt", "db_id": "P51743" }, { "db_name": "UniProt", "db_id": "P59684" }, { "db_name": "UniProt", "db_id": "P59693" }, { "db_name": "UniProt", "db_id": "P59694" }, { "db_name": "UniProt", "db_id": "P59695" }, { "db_name": "UniProt", "db_id": "P79337" }, { "db_name": "UniProt", "db_id": "P79374" }, { "db_name": "UniProt", "db_id": "Q06599" }, { "db_name": "UniProt", "db_id": "Q19LH4" }, { "db_name": "UniProt", "db_id": "Q1G1A2" }, { "db_name": "UniProt", "db_id": "Q1WM27" }, { "db_name": "UniProt", "db_id": "Q2MH05" }, { "db_name": "UniProt", "db_id": "Q539C2" }, { "db_name": "UniProt", "db_id": "Q75N23" }, { "db_name": "UniProt", "db_id": "Q8HZD9" }, { "db_name": "UniProt", "db_id": "Q8JFG3" }, { "db_name": "UniProt", "db_id": "Q8MKG8" }, { "db_name": "UniProt", "db_id": "Q8WNR1" }, { "db_name": "UniProt", "db_id": "Q9BEA1" } ] }, { "id": "DS.d496.s0.e2", "type": "protein", "text": [ "TNF-alpha" ], "offsets": [ [ 150, 159 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O35734" }, { "db_name": "UniProt", "db_id": "O77510" }, { "db_name": "UniProt", "db_id": "O77764" }, { "db_name": "UniProt", "db_id": "P01375" }, { "db_name": "UniProt", "db_id": "P04924" }, { "db_name": "UniProt", "db_id": "P06804" }, { "db_name": "UniProt", "db_id": "P13296" }, { "db_name": "UniProt", "db_id": "P16599" }, { "db_name": "UniProt", "db_id": "P19101" }, { "db_name": "UniProt", "db_id": "P23383" }, { "db_name": "UniProt", "db_id": "P23563" }, { "db_name": "UniProt", "db_id": "P29553" }, { "db_name": "UniProt", "db_id": "P33620" }, { "db_name": "UniProt", "db_id": "P36939" }, { "db_name": "UniProt", "db_id": "P48094" }, { "db_name": "UniProt", "db_id": "P51435" }, { "db_name": "UniProt", "db_id": "P51742" }, { "db_name": "UniProt", "db_id": "P51743" }, { "db_name": "UniProt", "db_id": "P59684" }, { "db_name": "UniProt", "db_id": "P59693" }, { "db_name": "UniProt", "db_id": "P59694" }, { "db_name": "UniProt", "db_id": "P59695" }, { "db_name": "UniProt", "db_id": "P79337" }, { "db_name": "UniProt", "db_id": "P79374" }, { "db_name": "UniProt", "db_id": "Q06599" }, { "db_name": "UniProt", "db_id": "Q19LH4" }, { "db_name": "UniProt", "db_id": "Q1G1A2" }, { "db_name": "UniProt", "db_id": "Q1WM27" }, { "db_name": "UniProt", "db_id": "Q2MH05" }, { "db_name": "UniProt", "db_id": "Q539C2" }, { "db_name": "UniProt", "db_id": "Q75N23" }, { "db_name": "UniProt", "db_id": "Q8HZD9" }, { "db_name": "UniProt", "db_id": "Q8JFG3" }, { "db_name": "UniProt", "db_id": "Q8MKG8" }, { "db_name": "UniProt", "db_id": "Q8WNR1" }, { "db_name": "UniProt", "db_id": "Q9BEA1" } ] }, { "id": "DS.d496.s0.e3", "type": "compound", "text": [ "caffeine" ], "offsets": [ [ 174, 182 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2519" } ] }, { "id": "DS.d496.s1.e0", "type": "protein", "text": [ "arginase" ], "offsets": [ [ 256, 264 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O49046" }, { "db_name": "UniProt", "db_id": "P00812" }, { "db_name": "UniProt", "db_id": "P0A2X9" }, { "db_name": "UniProt", "db_id": "P0A2Y0" }, { "db_name": "UniProt", "db_id": "P0A2Y1" }, { "db_name": "UniProt", "db_id": "P14012" }, { "db_name": "UniProt", "db_id": "P33280" }, { "db_name": "UniProt", "db_id": "P37818" }, { "db_name": "UniProt", "db_id": "P39138" }, { "db_name": "UniProt", "db_id": "P40906" }, { "db_name": "UniProt", "db_id": "P46637" }, { "db_name": "UniProt", "db_id": "P53608" }, { "db_name": "UniProt", "db_id": "P60086" }, { "db_name": "UniProt", "db_id": "P60087" }, { "db_name": "UniProt", "db_id": "P60088" }, { "db_name": "UniProt", "db_id": "Q10066" }, { "db_name": "UniProt", "db_id": "Q12611" }, { "db_name": "UniProt", "db_id": "Q1E180" }, { "db_name": "UniProt", "db_id": "Q6G7E9" }, { "db_name": "UniProt", "db_id": "Q6GER3" }, { "db_name": "UniProt", "db_id": "Q74ZW4" }, { "db_name": "UniProt", "db_id": "Q7M0Z3" }, { "db_name": "UniProt", "db_id": "Q8NVE3" } ] }, { "id": "DS.d496.s1.e1", "type": "compound", "text": [ "caffeine" ], "offsets": [ [ 290, 298 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2519" } ] } ]
[]
[]
[ { "id": "DS.d496.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d496.s1.e1", "arg2_id": "DS.d496.s1.e0", "normalized": [] } ]
DS.d497
18618245
[ { "id": "DS.d497.s0", "type": "", "text": [ "Comparison of the PTM's of MBP's isolated from several vertebrate species reveals marked differences in their phosphate content." ], "offsets": [ [ 0, 128 ] ] }, { "id": "DS.d497.s1", "type": "", "text": [ "Chicken MBP does not share any phosphorylated sites with dogfish MBP ; However, it does contain phosphorylated serine and threonine residues in common with mammalian MBP." ], "offsets": [ [ 129, 299 ] ] } ]
[ { "id": "DS.d497.s0.e0", "type": "protein", "text": [ "MBP" ], "offsets": [ [ 27, 30 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P02686" }, { "db_name": "UniProt", "db_id": "P02687" }, { "db_name": "UniProt", "db_id": "P04370" }, { "db_name": "UniProt", "db_id": "P06906" }, { "db_name": "UniProt", "db_id": "P13727" }, { "db_name": "UniProt", "db_id": "P15720" }, { "db_name": "UniProt", "db_id": "P20939" }, { "db_name": "UniProt", "db_id": "P25188" }, { "db_name": "UniProt", "db_id": "P25274" }, { "db_name": "UniProt", "db_id": "P25336" }, { "db_name": "UniProt", "db_id": "P81558" }, { "db_name": "UniProt", "db_id": "P83487" }, { "db_name": "UniProt", "db_id": "P87346" }, { "db_name": "UniProt", "db_id": "P98190" }, { "db_name": "UniProt", "db_id": "Q61878" }, { "db_name": "UniProt", "db_id": "Q63189" }, { "db_name": "UniProt", "db_id": "Q91325" }, { "db_name": "UniProt", "db_id": "Q91439" }, { "db_name": "UniProt", "db_id": "Q9SAV1" } ] }, { "id": "DS.d497.s0.e1", "type": "compound", "text": [ "phosphate" ], "offsets": [ [ 110, 119 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1061" }, { "db_name": "PubChem", "db_id": "167704" }, { "db_name": "PubChem", "db_id": "644102" } ] }, { "id": "DS.d497.s1.e0", "type": "protein", "text": [ "MBP" ], "offsets": [ [ 137, 140 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P02686" }, { "db_name": "UniProt", "db_id": "P02687" }, { "db_name": "UniProt", "db_id": "P04370" }, { "db_name": "UniProt", "db_id": "P06906" }, { "db_name": "UniProt", "db_id": "P13727" }, { "db_name": "UniProt", "db_id": "P15720" }, { "db_name": "UniProt", "db_id": "P20939" }, { "db_name": "UniProt", "db_id": "P25188" }, { "db_name": "UniProt", "db_id": "P25274" }, { "db_name": "UniProt", "db_id": "P25336" }, { "db_name": "UniProt", "db_id": "P81558" }, { "db_name": "UniProt", "db_id": "P83487" }, { "db_name": "UniProt", "db_id": "P87346" }, { "db_name": "UniProt", "db_id": "P98190" }, { "db_name": "UniProt", "db_id": "Q61878" }, { "db_name": "UniProt", "db_id": "Q63189" }, { "db_name": "UniProt", "db_id": "Q91325" }, { "db_name": "UniProt", "db_id": "Q91439" }, { "db_name": "UniProt", "db_id": "Q9SAV1" } ] }, { "id": "DS.d497.s1.e1", "type": "protein", "text": [ "MBP" ], "offsets": [ [ 194, 197 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P02686" }, { "db_name": "UniProt", "db_id": "P02687" }, { "db_name": "UniProt", "db_id": "P04370" }, { "db_name": "UniProt", "db_id": "P06906" }, { "db_name": "UniProt", "db_id": "P13727" }, { "db_name": "UniProt", "db_id": "P15720" }, { "db_name": "UniProt", "db_id": "P20939" }, { "db_name": "UniProt", "db_id": "P25188" }, { "db_name": "UniProt", "db_id": "P25274" }, { "db_name": "UniProt", "db_id": "P25336" }, { "db_name": "UniProt", "db_id": "P81558" }, { "db_name": "UniProt", "db_id": "P83487" }, { "db_name": "UniProt", "db_id": "P87346" }, { "db_name": "UniProt", "db_id": "P98190" }, { "db_name": "UniProt", "db_id": "Q61878" }, { "db_name": "UniProt", "db_id": "Q63189" }, { "db_name": "UniProt", "db_id": "Q91325" }, { "db_name": "UniProt", "db_id": "Q91439" }, { "db_name": "UniProt", "db_id": "Q9SAV1" } ] }, { "id": "DS.d497.s1.e2", "type": "compound", "text": [ "serine" ], "offsets": [ [ 240, 246 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5951" } ] }, { "id": "DS.d497.s1.e3", "type": "compound", "text": [ "threonine" ], "offsets": [ [ 251, 260 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6288" } ] }, { "id": "DS.d497.s1.e4", "type": "protein", "text": [ "MBP" ], "offsets": [ [ 194, 197 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P02686" }, { "db_name": "UniProt", "db_id": "P02687" }, { "db_name": "UniProt", "db_id": "P04370" }, { "db_name": "UniProt", "db_id": "P06906" }, { "db_name": "UniProt", "db_id": "P13727" }, { "db_name": "UniProt", "db_id": "P15720" }, { "db_name": "UniProt", "db_id": "P20939" }, { "db_name": "UniProt", "db_id": "P25188" }, { "db_name": "UniProt", "db_id": "P25274" }, { "db_name": "UniProt", "db_id": "P25336" }, { "db_name": "UniProt", "db_id": "P81558" }, { "db_name": "UniProt", "db_id": "P83487" }, { "db_name": "UniProt", "db_id": "P87346" }, { "db_name": "UniProt", "db_id": "P98190" }, { "db_name": "UniProt", "db_id": "Q61878" }, { "db_name": "UniProt", "db_id": "Q63189" }, { "db_name": "UniProt", "db_id": "Q91325" }, { "db_name": "UniProt", "db_id": "Q91439" }, { "db_name": "UniProt", "db_id": "Q9SAV1" } ] } ]
[]
[]
[ { "id": "DS.d497.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d497.s0.e1", "arg2_id": "DS.d497.s0.e0", "normalized": [] }, { "id": "DS.d497.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d497.s1.e3", "arg2_id": "DS.d497.s1.e0", "normalized": [] }, { "id": "DS.d497.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d497.s1.e2", "arg2_id": "DS.d497.s1.e0", "normalized": [] } ]
DS.d498
18618304
[ { "id": "DS.d498.s0", "type": "", "text": [ "Riluzole/NaPB administration increased acetylation at H4 and increased NF-kappaB p50 translocation to the nucleus in G93A mice, consistent with a therapeutic effect." ], "offsets": [ [ 0, 165 ] ] } ]
[ { "id": "DS.d498.s0.e0", "type": "compound", "text": [ "Riluzole" ], "offsets": [ [ 0, 8 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5070" } ] }, { "id": "DS.d498.s0.e1", "type": "compound", "text": [ "NaPB" ], "offsets": [ [ 9, 13 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "4775" } ] }, { "id": "DS.d498.s0.e2", "type": "protein", "text": [ "p50" ], "offsets": [ [ 81, 84 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P23061" }, { "db_name": "UniProt", "db_id": "P38644" }, { "db_name": "UniProt", "db_id": "P83939" }, { "db_name": "UniProt", "db_id": "Q05894" }, { "db_name": "UniProt", "db_id": "Q28618" }, { "db_name": "UniProt", "db_id": "Q43731" } ] } ]
[]
[]
[ { "id": "DS.d498.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d498.s0.e0", "arg2_id": "DS.d498.s0.e2", "normalized": [] }, { "id": "DS.d498.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d498.s0.e1", "arg2_id": "DS.d498.s0.e2", "normalized": [] } ]
DS.d499
18618472
[ { "id": "DS.d499.s0", "type": "", "text": [ "Due to the absence of hydrophobic solute-material interactions, which limit the scope of microstructures fabricated from poly(dimethylsiloxane) for biocatalytic applications, the new microreactor was fully compatible with the alternate enzyme substrate 2-nitro-phenyl-beta-D-galactoside and the 2-nitro-phenol product resulting from its hydrolysis catalyzed by CelB." ], "offsets": [ [ 0, 366 ] ] } ]
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[]
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DS.d500
18618621
[ { "id": "DS.d500.s0", "type": "", "text": [ "These findings suggest that multiple variations in the SLC6A4 gene are associated with remission in white non-Hispanic depressed adults treated with citalopram." ], "offsets": [ [ 0, 160 ] ] } ]
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DS.d501
18618694
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[ { "id": "DS.d501.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d501.s0.e1", "arg2_id": "DS.d501.s0.e2", "normalized": [] }, { "id": "DS.d501.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d501.s0.e0", "arg2_id": "DS.d501.s0.e2", "normalized": [] } ]
DS.d502
18618700
[ { "id": "DS.d502.s0", "type": "", "text": [ "At 0.15 microM Ca(2+), ((35)S) CaM bound to RyR2 with decreased affinity and binding enthalpy compared with RyR1." ], "offsets": [ [ 0, 113 ] ] }, { "id": "DS.d502.s1", "type": "", "text": [ "The rates of ((35)S) CaM dissociation from RyR1 increased as the temperature was raised, whereas at 0.15 microM Ca(2+) the rate from RyR2 was little affected." ], "offsets": [ [ 114, 272 ] ] } ]
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[]
[]
[]
DS.d503
18619522
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[]
[]
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DS.d504
18619705
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[]
[]
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DS.d505
18619713
[ { "id": "DS.d505.s0", "type": "", "text": [ "The ubiquitous enzyme dUTP nucleotidohydrolase (dUTPase) catalyses the hydrolysis of dUTP to dUMP and can be considered as the first line of defence against incorporation of uracil into DNA." ], "offsets": [ [ 0, 190 ] ] } ]
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"UniProt", "db_id": "Q9HTN3" }, { "db_name": "UniProt", "db_id": "Q9J5G5" }, { "db_name": "UniProt", "db_id": "Q9JUW1" }, { "db_name": "UniProt", "db_id": "Q9JZU7" }, { "db_name": "UniProt", "db_id": "Q9P6Q5" }, { "db_name": "UniProt", "db_id": "Q9PGZ6" }, { "db_name": "UniProt", "db_id": "Q9PKA2" }, { "db_name": "UniProt", "db_id": "Q9X3X5" }, { "db_name": "UniProt", "db_id": "Q9YG32" }, { "db_name": "UniProt", "db_id": "Q9YYS0" }, { "db_name": "UniProt", "db_id": "Q9Z9C2" }, { "db_name": "UniProt", "db_id": "Q9ZDD2" }, { "db_name": "UniProt", "db_id": "Q9ZKY3" } ] }, { "id": "DS.d505.s0.e1", "type": "compound", "text": [ "uracil" ], "offsets": [ [ 174, 180 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1174" } ] } ]
[]
[]
[]
DS.d506
18621093
[ { "id": "DS.d506.s0", "type": "", "text": [ "Recent findings indicate that the polypyrimidine tract-binding protein (PTB), also named hnRNP I, by binding to the 3'-UTR (untranslated region) of the preproinsulin mRNA molecule, stabilizes the messenger, thereby participating in the glucose-induced increase in preproinsulin mRNA." ], "offsets": [ [ 0, 283 ] ] } ]
[ { "id": "DS.d506.s0.e0", "type": "protein", "text": [ "PTB" ], "offsets": [ [ 72, 75 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P17225" }, { "db_name": "UniProt", "db_id": "P26599" }, { "db_name": "UniProt", "db_id": "Q00438" }, { "db_name": "UniProt", "db_id": "Q29099" }, { "db_name": "UniProt", "db_id": "Q8WN55" }, { "db_name": "UniProt", "db_id": "Q9MAC5" }, { "db_name": "UniProt", "db_id": "Q9UKA9" } ] }, { "id": "DS.d506.s0.e1", "type": "protein", "text": [ "hnRNP I" ], "offsets": [ [ 89, 96 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P17225" }, { "db_name": "UniProt", "db_id": "P26599" }, { "db_name": "UniProt", "db_id": "Q00438" }, { "db_name": "UniProt", "db_id": "Q29099" } ] }, { "id": "DS.d506.s0.e2", "type": "compound", "text": [ "glucose" ], "offsets": [ [ 236, 243 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "206" }, { "db_name": "PubChem", "db_id": "5793" }, { "db_name": "PubChem", "db_id": "64689" }, { "db_name": "PubChem", "db_id": "79025" } ] } ]
[]
[]
[ { "id": "DS.d506.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d506.s0.e2", "arg2_id": "DS.d506.s0.e0", "normalized": [] }, { "id": "DS.d506.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d506.s0.e2", "arg2_id": "DS.d506.s0.e1", "normalized": [] } ]
DS.d507
18621373
[ { "id": "DS.d507.s0", "type": "", "text": [ "Pretreatment with extracellular signal-regulated kinase (ERK) and Jun N-terminal kinase (JNK) inhibitors, but not p38 mitogen-activated protein kinase (p38MAPK) significantly decreased CRP-induced superoxide anion release from macrophages in vivo." ], "offsets": [ [ 0, 247 ] ] } ]
[ { "id": "DS.d507.s0.e0", "type": "protein", "text": [ "p38MAPK" ], "offsets": [ [ 152, 159 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O62618" } ] }, { "id": "DS.d507.s0.e1", "type": "protein", "text": [ "CRP" ], "offsets": [ [ 185, 188 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O19062" }, { "db_name": "UniProt", "db_id": "P02741" }, { "db_name": "UniProt", "db_id": "P02742" }, { "db_name": "UniProt", "db_id": "P08462" }, { "db_name": "UniProt", "db_id": "P18151" }, { "db_name": "UniProt", "db_id": "P21291" }, { "db_name": "UniProt", "db_id": "P41964" }, { "db_name": "UniProt", "db_id": "P47875" }, { "db_name": "UniProt", "db_id": "P49254" }, { "db_name": "UniProt", "db_id": "P49262" }, { "db_name": "UniProt", "db_id": "P52753" }, { "db_name": "UniProt", "db_id": "P67966" }, { "db_name": "UniProt", "db_id": "P67967" }, { "db_name": "UniProt", "db_id": "P97315" }, { "db_name": "UniProt", "db_id": "Q07203" } ] }, { "id": "DS.d507.s0.e2", "type": "compound", "text": [ "superoxide" ], "offsets": [ [ 197, 207 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5359597" } ] } ]
[]
[]
[ { "id": "DS.d507.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d507.s0.e2", "arg2_id": "DS.d507.s0.e1", "normalized": [] } ]
DS.d508
18621413
[ { "id": "DS.d508.s0", "type": "", "text": [ "The free radicals produced are thought to be generated during the production of uric acid, a reaction catalyzed by xanthine oxidase." ], "offsets": [ [ 0, 132 ] ] } ]
[ { "id": "DS.d508.s0.e0", "type": "compound", "text": [ "uric acid" ], "offsets": [ [ 80, 89 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1175" } ] }, { "id": "DS.d508.s0.e1", "type": "protein", "text": [ "xanthine oxidase" ], "offsets": [ [ 115, 131 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P22985" }, { "db_name": "UniProt", "db_id": "P47989" }, { "db_name": "UniProt", "db_id": "P47990" }, { "db_name": "UniProt", "db_id": "P80457" }, { "db_name": "UniProt", "db_id": "Q00519" }, { "db_name": "UniProt", "db_id": "Q9MYW6" } ] } ]
[]
[]
[ { "id": "DS.d508.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d508.s0.e0", "arg2_id": "DS.d508.s0.e1", "normalized": [] } ]
DS.d509
18621448
[ { "id": "DS.d509.s0", "type": "", "text": [ "In the diabetic group, a decrease in the pancreatic glutathione levels, glutathione peroxidase and superoxide dismutase activities and an increase in the pancreatic lipid peroxidation level and catalase activities were observed." ], "offsets": [ [ 0, 228 ] ] } ]
[ { "id": "DS.d509.s0.e0", "type": "compound", "text": [ "glutathione" ], "offsets": [ [ 52, 63 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "124886" } ] }, { "id": "DS.d509.s0.e1", "type": "protein", "text": [ "glutathione peroxidase" ], "offsets": [ [ 72, 94 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O32770" }, { "db_name": "UniProt", "db_id": "O59858" }, { "db_name": "UniProt", "db_id": "Q00277" }, { "db_name": "UniProt", "db_id": "Q9CFV1" } ] }, { "id": "DS.d509.s0.e2", "type": "protein", "text": [ "superoxide dismutase" ], "offsets": [ [ 99, 119 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O50258" } ] }, { "id": "DS.d509.s0.e3", "type": "protein", "text": [ "catalase" ], "offsets": [ [ 194, 202 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O24339" }, { "db_name": "UniProt", "db_id": "O52762" }, { "db_name": "UniProt", "db_id": "O62839" }, { "db_name": "UniProt", "db_id": "O68146" }, { "db_name": "UniProt", "db_id": "O77229" }, { "db_name": "UniProt", "db_id": "O93662" }, { "db_name": "UniProt", "db_id": "O97492" }, { "db_name": "UniProt", "db_id": "P00432" }, { "db_name": "UniProt", "db_id": "P04040" }, { "db_name": "UniProt", "db_id": "P04762" }, { "db_name": "UniProt", "db_id": "P07145" }, { "db_name": "UniProt", "db_id": "P0A323" }, { "db_name": "UniProt", "db_id": "P0A324" }, { "db_name": "UniProt", "db_id": "P0A325" }, { "db_name": "UniProt", "db_id": "P0A326" }, { "db_name": "UniProt", "db_id": "P0A327" }, { "db_name": "UniProt", "db_id": "P11934" }, { "db_name": "UniProt", "db_id": "P17336" }, { "db_name": "UniProt", "db_id": "P24168" }, { "db_name": "UniProt", "db_id": "P24270" }, { "db_name": "UniProt", "db_id": "P25890" }, { "db_name": "UniProt", "db_id": "P29422" }, { "db_name": "UniProt", "db_id": "P30265" }, { "db_name": "UniProt", "db_id": "P30266" }, { "db_name": "UniProt", "db_id": "P32290" }, { "db_name": "UniProt", "db_id": "P42321" }, { "db_name": "UniProt", "db_id": "P44390" }, { "db_name": "UniProt", "db_id": "P45737" }, { "db_name": "UniProt", "db_id": "P45739" }, { "db_name": "UniProt", "db_id": "P55304" }, { "db_name": "UniProt", "db_id": "P55306" }, { "db_name": "UniProt", "db_id": "P55310" }, { "db_name": "UniProt", "db_id": "P55311" }, { "db_name": "UniProt", "db_id": "P55313" }, { "db_name": "UniProt", "db_id": "P77872" }, { "db_name": "UniProt", "db_id": "P81138" }, { "db_name": "UniProt", "db_id": "P90682" }, { "db_name": "UniProt", "db_id": "Q27710" }, { "db_name": "UniProt", "db_id": "Q49XC1" }, { "db_name": "UniProt", "db_id": "Q4L643" }, { "db_name": "UniProt", "db_id": "Q59296" }, { "db_name": "UniProt", "db_id": "Q59337" }, { "db_name": "UniProt", "db_id": "Q59602" }, { "db_name": "UniProt", "db_id": "Q59714" }, { "db_name": "UniProt", "db_id": "Q5HG86" }, { "db_name": "UniProt", "db_id": "Q5HPK8" }, { "db_name": "UniProt", "db_id": "Q5RF10" }, { "db_name": "UniProt", "db_id": "Q64405" }, { "db_name": "UniProt", "db_id": "Q6G9M4" }, { "db_name": "UniProt", "db_id": "Q6GH72" }, { "db_name": "UniProt", "db_id": "Q7A5T2" }, { "db_name": "UniProt", "db_id": "Q8CPD0" }, { "db_name": "UniProt", "db_id": "Q8FWU0" }, { "db_name": "UniProt", "db_id": "Q8NWV5" }, { "db_name": "UniProt", "db_id": "Q8X1P0" }, { "db_name": "UniProt", "db_id": "Q8Y3P9" }, { "db_name": "UniProt", "db_id": "Q926X0" }, { "db_name": "UniProt", "db_id": "Q99UE2" }, { "db_name": "UniProt", "db_id": "Q9AXH0" }, { "db_name": "UniProt", "db_id": "Q9KW19" }, { "db_name": "UniProt", "db_id": "Q9L4S1" }, { "db_name": "UniProt", "db_id": "Q9M5L6" }, { "db_name": "UniProt", "db_id": "Q9PT92" }, { "db_name": "UniProt", "db_id": "Q9PWF7" }, { "db_name": "UniProt", "db_id": "Q9Z598" }, { "db_name": "UniProt", "db_id": "Q9ZKX5" }, { "db_name": "UniProt", "db_id": "Q9ZN99" } ] } ]
[]
[]
[]
DS.d510
18621563
[ { "id": "DS.d510.s0", "type": "", "text": [ "The immunomodulatory effects of thalidomide are at least partially mediated through its ability to down-regulate the pathogenic over-production of tumor necrosis factor-alpha (TNF-alpha)." ], "offsets": [ [ 0, 187 ] ] }, { "id": "DS.d510.s1", "type": "", "text": [ "In the central nervous system, TNF-alpha is involved in induction of a fever response and triggers the release of other cytokines, and may also influence transport of compounds into the brain, leading to cerebrospinal fluid leukocytosis, increased protein influx, and lactate accumulation." ], "offsets": [ [ 188, 477 ] ] }, { "id": "DS.d510.s2", "type": "", "text": [ "Thalidomide has been shown to down-regulate the production of TNF-alpha." ], "offsets": [ [ 478, 550 ] ] } ]
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456, 463 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "612" } ] }, { "id": "DS.d510.s2.e0", "type": "compound", "text": [ "Thalidomide" ], "offsets": [ [ 478, 489 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5426" }, { "db_name": "PubChem", "db_id": "75792" }, { "db_name": "PubChem", "db_id": "92142" } ] }, { "id": "DS.d510.s2.e1", "type": "protein", "text": [ "TNF-alpha" ], "offsets": [ [ 540, 549 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O35734" }, { "db_name": "UniProt", "db_id": "O77510" }, { "db_name": "UniProt", "db_id": "O77764" }, { "db_name": "UniProt", "db_id": "P01375" }, { "db_name": "UniProt", "db_id": "P04924" }, { "db_name": "UniProt", "db_id": "P06804" }, { "db_name": "UniProt", "db_id": "P13296" }, { "db_name": "UniProt", "db_id": "P16599" }, { "db_name": "UniProt", "db_id": "P19101" }, { "db_name": "UniProt", "db_id": "P23383" }, { "db_name": "UniProt", "db_id": "P23563" }, { "db_name": "UniProt", "db_id": "P29553" }, { "db_name": 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"db_id": "Q8WNR1" }, { "db_name": "UniProt", "db_id": "Q9BEA1" } ] } ]
[]
[]
[ { "id": "DS.d510.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d510.s0.e0", "arg2_id": "DS.d510.s0.e2", "normalized": [] }, { "id": "DS.d510.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d510.s0.e0", "arg2_id": "DS.d510.s0.e1", "normalized": [] }, { "id": "DS.d510.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d510.s1.e1", "arg2_id": "DS.d510.s1.e0", "normalized": [] }, { "id": "DS.d510.s2.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d510.s2.e0", "arg2_id": "DS.d510.s2.e1", "normalized": [] } ]
DS.d511
18622696
[ { "id": "DS.d511.s0", "type": "", "text": [ "Both cell types expressed estrogen and progesterone receptors, although only the epithelial LM05-E cells were stimulated by estradiol and inhibited by tamoxifen." ], "offsets": [ [ 0, 161 ] ] } ]
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[]
[]
[]
DS.d512
18622720
[ { "id": "DS.d512.s0", "type": "", "text": [ "This study was performed to investigate the effect of combined treatment with niacin and chromium on vascular endothelial dysfunction, with the aim of gaining insight to the mechanisms by detecting the expression levels of ox-LDL and LOX-1." ], "offsets": [ [ 0, 240 ] ] }, { "id": "DS.d512.s1", "type": "", "text": [ "In HF group, the serum levels of total cholesterol (TC), low-density lipoprotein (LDL), oxidized low-density lipoprotein (ox-LDL) and endothelin (ET) were higher, whereas the levels of high-density lipoprotein (HDL), serum NO were lower than those in CG group." ], "offsets": [ [ 241, 501 ] ] }, { "id": "DS.d512.s2", "type": "", "text": [ "These findings indicated that combined treatment with niacin and chromium has potential therapeutic protection of endothelial function by down-regulating ox-LDL/LOX-1 signaling pathway." ], "offsets": [ [ 502, 687 ] ] } ]
[ { "id": "DS.d512.s0.e0", "type": "compound", "text": [ "niacin" ], "offsets": [ [ 78, 84 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "938" } ] }, { "id": "DS.d512.s0.e1", "type": "compound", "text": [ "chromium" ], "offsets": [ [ 89, 97 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "23976" } ] }, { "id": "DS.d512.s0.e2", "type": "protein", "text": [ "LOX-1" ], "offsets": [ [ 234, 239 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O70156" }, { "db_name": "UniProt", "db_id": "P78380" }, { "db_name": "UniProt", "db_id": "P79391" }, { "db_name": "UniProt", "db_id": "Q9EQ09" }, { "db_name": "UniProt", "db_id": "Q9TTK7" }, { "db_name": "UniProt", "db_id": "Q9XTA8" } ] }, { "id": "DS.d512.s1.e0", "type": "compound", "text": [ "cholesterol" ], "offsets": [ [ 280, 291 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "304" }, { "db_name": "PubChem", "db_id": "5997" }, { "db_name": "PubChem", "db_id": "6432564" }, { "db_name": "PubChem", "db_id": "11025495" } ] }, { "id": "DS.d512.s1.e1", "type": "protein", "text": [ "high-density lipoprotein" ], "offsets": [ [ 426, 450 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P81182" } ] }, { "id": "DS.d512.s2.e0", "type": "compound", "text": [ "niacin" ], "offsets": [ [ 556, 562 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "938" } ] }, { "id": "DS.d512.s2.e1", "type": "compound", "text": [ "chromium" ], "offsets": [ [ 567, 575 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "23976" } ] }, { "id": "DS.d512.s2.e2", "type": "protein", "text": [ "LOX-1" ], "offsets": [ [ 663, 668 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O70156" }, { "db_name": "UniProt", "db_id": "P78380" }, { "db_name": "UniProt", "db_id": "P79391" }, { "db_name": "UniProt", "db_id": "Q9EQ09" }, { "db_name": "UniProt", "db_id": "Q9TTK7" }, { "db_name": "UniProt", "db_id": "Q9XTA8" } ] } ]
[]
[]
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DS.d513
18622759
[ { "id": "DS.d513.s0", "type": "", "text": [ "The deduced amino acid sequence of Ai Lec was highly similar to those of the C-type lectins from other animals and contained a typical carbohydrate-recognition domain (CRD) of 131 residues, which has four conserved disulfide-bonded cysteine residues that define the CRD and two additional cysteine residues at the amino terminus." ], "offsets": [ [ 0, 329 ] ] } ]
[ { "id": "DS.d513.s0.e0", "type": "protein", "text": [ "lectins" ], "offsets": [ [ 84, 91 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P02871" }, { "db_name": "UniProt", "db_id": "P02873" }, { "db_name": "UniProt", "db_id": "P02874" }, { "db_name": "UniProt", "db_id": "P02875" }, { "db_name": "UniProt", "db_id": "P07386" }, { "db_name": "UniProt", "db_id": "P16108" }, { "db_name": "UniProt", "db_id": "P16349" }, { "db_name": "UniProt", "db_id": "P16351" }, { "db_name": "UniProt", "db_id": "P16352" }, { "db_name": "UniProt", "db_id": "P33888" }, { "db_name": "UniProt", "db_id": "P38662" }, { "db_name": "UniProt", "db_id": "P42088" }, { "db_name": "UniProt", "db_id": "P83410" }, { "db_name": "UniProt", "db_id": "P83511" }, { "db_name": "UniProt", "db_id": "P84987" }, { "db_name": "UniProt", "db_id": "Q41114" } ] }, { "id": "DS.d513.s0.e1", "type": "compound", "text": [ "cysteine" ], "offsets": [ [ 232, 240 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "594" }, { "db_name": "PubChem", "db_id": "5862" }, { "db_name": "PubChem", "db_id": "5360637" } ] }, { "id": "DS.d513.s0.e2", "type": "compound", "text": [ "cysteine" ], "offsets": [ [ 289, 297 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "594" }, { "db_name": "PubChem", "db_id": "5862" }, { "db_name": "PubChem", "db_id": "5360637" } ] } ]
[]
[]
[ { "id": "DS.d513.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d513.s0.e1", "arg2_id": "DS.d513.s0.e0", "normalized": [] } ]
DS.d514
18623061
[ { "id": "DS.d514.s0", "type": "", "text": [ "Src kinases can be activated by trans-phosphorylation of a tyrosine located in the central activation loop of the catalytic domain." ], "offsets": [ [ 0, 131 ] ] }, { "id": "DS.d514.s1", "type": "", "text": [ "However, because the required exposure of this tyrosine is not observed in the down-regulated X-ray structures of Src kinases, transient partial opening of the activation loop appears to be necessary for such processes." ], "offsets": [ [ 132, 351 ] ] } ]
[ { "id": "DS.d514.s0.e0", "type": "protein", "text": [ "Src" ], "offsets": [ [ 0, 3 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P05480" }, { "db_name": "UniProt", "db_id": "Q9WUD9" } ] }, { "id": "DS.d514.s0.e1", "type": "compound", "text": [ "tyrosine" ], "offsets": [ [ 59, 67 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1153" }, { "db_name": "PubChem", "db_id": "6057" }, { "db_name": "PubChem", "db_id": "5460803" } ] }, { "id": "DS.d514.s1.e0", "type": "compound", "text": [ "tyrosine" ], "offsets": [ [ 179, 187 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1153" }, { "db_name": "PubChem", "db_id": "6057" }, { "db_name": "PubChem", "db_id": "5460803" } ] }, { "id": "DS.d514.s1.e1", "type": "protein", "text": [ "Src" ], "offsets": [ [ 246, 249 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P05480" }, { "db_name": "UniProt", "db_id": "Q9WUD9" } ] } ]
[]
[]
[ { "id": "DS.d514.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d514.s0.e1", "arg2_id": "DS.d514.s0.e0", "normalized": [] } ]
DS.d515
18623078
[ { "id": "DS.d515.s0", "type": "", "text": [ "The growth of L. minor (as fresh weight) and chlorophyll a content were significantly reduced and superoxide dismutase (SOD) activity was significantly decreased at microcystins concentration up to 0.5 mg/L." ], "offsets": [ [ 0, 207 ] ] }, { "id": "DS.d515.s1", "type": "", "text": [ "The experiment also indicated that catalase (CAT) activity was not significantly influenced by microcystin for both the two tested aquatic plants." ], "offsets": [ [ 208, 354 ] ] } ]
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[]
[]
DS.d516
18623211
[ { "id": "DS.d516.s0", "type": "", "text": [ "The purpose of this study was to investigate the solid-state properties of lyophilized formulations of protein (ribonuclease A) containing sucrose or trehalose across a wide range of compositions, both in the presence or absence of hydroxyethylstarch (HES)." ], "offsets": [ [ 0, 257 ] ] } ]
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[]
[]
[]
DS.d517
18624726
[ { "id": "DS.d517.s0", "type": "", "text": [ "The stimulatory effects of stearic, palmitic and palmitoleic acids on resistin secretion and the stimulatory effect of stearic acid on MCP-1 secretion are mediated via TLR-4." ], "offsets": [ [ 0, 174 ] ] } ]
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[]
[]
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