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DS.d621
18656273
[ { "id": "DS.d621.s0", "type": "", "text": [ "Resveratrol reverses ET-1-evoked mitogenic effects in human coronary arterial cells by activating the kinase-G to inhibit ERK-enzymes." ], "offsets": [ [ 0, 134 ] ] }, { "id": "DS.d621.s1", "type": "", "text": [ "Pretreatment with the MEK-ERK inhibitor (PD98059) appreciably reversed the mitogenic effects of ET-1." ], "offsets": [ [ 135, 236 ] ] }, { "id": "DS.d621.s2", "type": "", "text": [ "On the other hand, pretreatment with the polyphenolic stilbene resveratrol (RSVL, 1-100 microM) triggered more prominent inhibition of ET-1-evoked cell proliferation and ERK1/2 activation." ], "offsets": [ [ 237, 425 ] ] }, { "id": "DS.d621.s3", "type": "", "text": [ "Further, pretreatment with the specific cGMP-phosphodiesterase inhibitor, zaprinast (10 microM) appreciably augmented RSVL-evoked cGMP formation, ERK inhibition, and cytostatic response." ], "offsets": [ [ 426, 612 ] ] }, { "id": "DS.d621.s4", "type": "", "text": [ "Moreover, the RSVL-induced ERK-inhibitory effects were significantly reversed by the kinase-G inhibitor, KT-5823 (10 microM; 69%), but not by the kinase-A inhibitor (KT-5720)." ], "offsets": [ [ 613, 788 ] ] } ]
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[]
[]
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DS.d622
18656335
[ { "id": "DS.d622.s0", "type": "", "text": [ "Adding beta-carotene to the diet of the mice during the period of irradiation suppressed the activity and expression of MMP-9 as well as the wrinkling and sagging formation." ], "offsets": [ [ 0, 173 ] ] }, { "id": "DS.d622.s1", "type": "", "text": [ "Dietary beta-carotene prevents the expression of MMP-9, at least partly, by inhibiting photodynamic action involved in the formation of Chol-OOHs." ], "offsets": [ [ 174, 320 ] ] } ]
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[]
[]
[ { "id": "DS.d622.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d622.s0.e0", "arg2_id": "DS.d622.s0.e1", "normalized": [] }, { "id": "DS.d622.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d622.s1.e0", "arg2_id": "DS.d622.s1.e1", "normalized": [] } ]
DS.d623
18656337
[ { "id": "DS.d623.s0", "type": "", "text": [ "Exposure to linoleic acid for 6 h induced expression of both caveolin-1 and cyclooxygenase (COX)-2." ], "offsets": [ [ 0, 99 ] ] }, { "id": "DS.d623.s1", "type": "", "text": [ "Pretreatment with EGCG blocked fatty-acid-induced caveolin-1 and COX-2 expression in a time- and concentration-dependent manner." ], "offsets": [ [ 100, 228 ] ] }, { "id": "DS.d623.s2", "type": "", "text": [ "Exposure to linoleic acid rapidly increased phosphorylation of several kinases, including p38 MAPK, extracellular signal regulated kinase 1/2 (ERK1/2) and amino kinase terminal (Akt), with maximal induction at about 10 min." ], "offsets": [ [ 229, 452 ] ] }, { "id": "DS.d623.s3", "type": "", "text": [ "Inhibitors of ERK1/2 and Akt down-regulated the linoleic-acid-induced increase in COX-2 protein, which also occurred after pretreatment with EGCG." ], "offsets": [ [ 453, 599 ] ] }, { "id": "DS.d623.s4", "type": "", "text": [ "Caveolin-1 silencing blocked linoleic-acid-induced phosphorylation of ERK1/2 and protein expression of COX-2, suggesting that specific MAPK signaling is caveolae dependent." ], "offsets": [ [ 600, 772 ] ] } ]
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"Q07E38" }, { "db_name": "UniProt", "db_id": "Q07E49" }, { "db_name": "UniProt", "db_id": "Q09YH8" }, { "db_name": "UniProt", "db_id": "Q09YK1" }, { "db_name": "UniProt", "db_id": "Q09YN6" }, { "db_name": "UniProt", "db_id": "Q108U7" }, { "db_name": "UniProt", "db_id": "Q2IBA5" }, { "db_name": "UniProt", "db_id": "Q2IBC1" }, { "db_name": "UniProt", "db_id": "Q2IBD7" }, { "db_name": "UniProt", "db_id": "Q2IBF0" }, { "db_name": "UniProt", "db_id": "Q2IBG8" }, { "db_name": "UniProt", "db_id": "Q2QL79" }, { "db_name": "UniProt", "db_id": "Q2QL90" }, { "db_name": "UniProt", "db_id": "Q2QLB0" }, { "db_name": "UniProt", "db_id": "Q2QLC1" }, { "db_name": "UniProt", "db_id": "Q2QLF2" }, { "db_name": "UniProt", "db_id": "Q2QLG6" }, { "db_name": "UniProt", "db_id": "Q2QLH7" }, { "db_name": "UniProt", "db_id": "Q6B3Y2" }, { "db_name": "UniProt", "db_id": "Q6RVA9" }, { "db_name": "UniProt", "db_id": "Q94051" }, { "db_name": "UniProt", "db_id": "Q9YGM8" } ] }, { "id": "DS.d623.s1.e2", "type": "protein", "text": [ "COX-2" ], "offsets": [ [ 165, 170 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O02768" }, { "db_name": "UniProt", "db_id": "O19183" }, { "db_name": "UniProt", "db_id": "O62698" }, { "db_name": "UniProt", "db_id": "O62725" }, { "db_name": "UniProt", "db_id": "P27607" }, { "db_name": "UniProt", "db_id": "P35354" }, { "db_name": "UniProt", "db_id": "P35355" }, { "db_name": "UniProt", "db_id": "P70682" }, { "db_name": "UniProt", "db_id": "P79208" }, { "db_name": "UniProt", "db_id": "Q05769" } ] }, { "id": "DS.d623.s2.e0", "type": "compound", "text": [ "linoleic acid" ], "offsets": [ [ 241, 254 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5280450" } ] }, { "id": "DS.d623.s2.e1", "type": "protein", "text": [ "p38 MAPK" ], "offsets": [ [ 319, 327 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O62618" } ] }, { "id": "DS.d623.s2.e2", "type": "protein", "text": [ "extracellular signal regulated kinase 1" ], "offsets": [ [ 329, 368 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P21708" }, { "db_name": "UniProt", "db_id": "P27361" }, { "db_name": "UniProt", "db_id": "P28869" }, { "db_name": "UniProt", "db_id": "P42525" }, { "db_name": "UniProt", "db_id": "Q63844" } ] }, { "id": "DS.d623.s2.e3", "type": "protein", "text": [ "ERK1" ], "offsets": [ [ 372, 376 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P27361" }, { "db_name": "UniProt", "db_id": "P28869" }, { "db_name": "UniProt", "db_id": "P42525" }, { "db_name": "UniProt", "db_id": "Q07176" } ] }, { "id": "DS.d623.s2.e4", "type": "protein", "text": [ "Akt" ], "offsets": [ [ 407, 410 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P31750" }, { "db_name": "UniProt", "db_id": "Q8INB9" } ] }, { "id": "DS.d623.s3.e0", "type": "compound", "text": [ "linoleic-acid" ], "offsets": [ [ 501, 514 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5280450" } ] }, { "id": "DS.d623.s3.e1", "type": "protein", "text": [ "COX-2" ], "offsets": [ [ 535, 540 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O02768" }, { "db_name": "UniProt", "db_id": "O19183" }, { "db_name": "UniProt", "db_id": "O62698" }, { "db_name": "UniProt", "db_id": "O62725" }, { "db_name": "UniProt", "db_id": "P27607" }, { "db_name": "UniProt", "db_id": "P35354" }, { "db_name": "UniProt", "db_id": "P35355" }, { "db_name": "UniProt", "db_id": "P70682" }, { "db_name": "UniProt", "db_id": "P79208" }, { "db_name": "UniProt", "db_id": "Q05769" } ] }, { "id": "DS.d623.s3.e2", "type": "compound", "text": [ "EGCG" ], "offsets": [ [ 594, 598 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "65064" } ] }, { "id": "DS.d623.s4.e0", "type": "protein", "text": [ "Caveolin-1" ], "offsets": [ [ 600, 610 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P33724" }, { "db_name": "UniProt", "db_id": "P35431" }, { "db_name": "UniProt", "db_id": "P41350" }, { "db_name": "UniProt", "db_id": "P49817" }, { "db_name": "UniProt", "db_id": "P79132" }, { "db_name": "UniProt", 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[]
[]
[ { "id": "DS.d623.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d623.s0.e0", "arg2_id": "DS.d623.s0.e2", "normalized": [] }, { "id": "DS.d623.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d623.s0.e0", "arg2_id": "DS.d623.s0.e1", "normalized": [] }, { "id": "DS.d623.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d623.s1.e0", "arg2_id": "DS.d623.s1.e1", "normalized": [] }, { "id": "DS.d623.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d623.s1.e0", "arg2_id": "DS.d623.s1.e2", "normalized": [] }, { "id": "DS.d623.s2.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d623.s2.e0", "arg2_id": "DS.d623.s2.e1", "normalized": [] }, { "id": "DS.d623.s2.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d623.s2.e0", "arg2_id": "DS.d623.s2.e4", "normalized": [] }, { "id": "DS.d623.s2.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d623.s2.e0", "arg2_id": "DS.d623.s2.e2", "normalized": [] }, { "id": "DS.d623.s2.i3", "type": "compound-protein-interaction", "arg1_id": "DS.d623.s2.e0", "arg2_id": "DS.d623.s2.e3", "normalized": [] }, { "id": "DS.d623.s3.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d623.s3.e0", "arg2_id": "DS.d623.s3.e1", "normalized": [] }, { "id": "DS.d623.s3.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d623.s3.e2", "arg2_id": "DS.d623.s3.e1", "normalized": [] }, { "id": "DS.d623.s4.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d623.s4.e1", "arg2_id": "DS.d623.s4.e2", "normalized": [] }, { "id": "DS.d623.s4.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d623.s4.e1", "arg2_id": "DS.d623.s4.e4", "normalized": [] }, { "id": "DS.d623.s4.i3", "type": "compound-protein-interaction", "arg1_id": "DS.d623.s4.e1", "arg2_id": "DS.d623.s4.e3", "normalized": [] } ]
DS.d624
18656338
[ { "id": "DS.d624.s0", "type": "", "text": [ "Apigenin causes G(2)/M arrest associated with the modulation of p21 (Cip1) and Cdc2 and activates p53-dependent apoptosis pathway in human breast cancer SK-BR-3 cells." ], "offsets": [ [ 0, 167 ] ] }, { "id": "DS.d624.s1", "type": "", "text": [ "To investigate the regulatory proteins of cell cycle arrest affected by apigenin, we treated cells with 50 and 100 microM apigenin for 72 h. Apigenin caused a slight decrease in cyclin D and cyclin E expression, with no change in CDK2 and CDK4." ], "offsets": [ [ 168, 412 ] ] }, { "id": "DS.d624.s2", "type": "", "text": [ "In addition, the apigenin-induced accumulation of the cell population in the G(2)/M phase resulted in a decrease in CDK1 together with cyclin A and cyclin B." ], "offsets": [ [ 413, 570 ] ] }, { "id": "DS.d624.s3", "type": "", "text": [ "In an additional study, apigenin also increased the accumulation of p53 and further enhanced the level of p21 (Cip1), with no change in p27 (Kip1)." ], "offsets": [ [ 571, 718 ] ] }, { "id": "DS.d624.s4", "type": "", "text": [ "The expression of Bax and cytochrome c of p53 downstream target was increased markedly at high concentration treatment over 50 microM apigenin." ], "offsets": [ [ 719, 862 ] ] } ]
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[]
[]
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DS.d625
18656400
[ { "id": "DS.d625.s0", "type": "", "text": [ "Therefore, we next examined whether 5-HT2A and 5-HT2C receptors are involved, and from where 5-HT is released in the formalin test." ], "offsets": [ [ 0, 131 ] ] }, { "id": "DS.d625.s1", "type": "", "text": [ "These results indicate that 5-HT released into peripheral tissue and its receptors, 5-HT2A as well as 5-HT2C, at the periphery have an important role in pain-related behaviors during acute peripheral inflammation." ], "offsets": [ [ 132, 345 ] ] } ]
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[]
[]
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DS.d626
18656896
[ { "id": "DS.d626.s0", "type": "", "text": [ "Haloperidol strongly decreased the expression of BDNF 0.01)." ], "offsets": [ [ 0, 60 ] ] }, { "id": "DS.d626.s1", "type": "", "text": [ "In contrast, the administration of ziprasidone significantly attenuated the immobilization stress-induced decrease in BDNF 0.01)." ], "offsets": [ [ 61, 190 ] ] }, { "id": "DS.d626.s2", "type": "", "text": [ "Ziprasidone exhibited differential effects on BDNF mRNA expression in the rat hippocampus and neocortex." ], "offsets": [ [ 191, 295 ] ] }, { "id": "DS.d626.s3", "type": "", "text": [ "These results suggest that ziprasidone might have a neuroprotective effect by recovering stress-induced decreases in BDNF mRNA expression." ], "offsets": [ [ 296, 434 ] ] } ]
[ { "id": "DS.d626.s0.e0", "type": "compound", "text": [ "Haloperidol" ], "offsets": [ [ 0, 11 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "3559" } ] }, { "id": "DS.d626.s0.e1", "type": "protein", "text": [ "BDNF" ], "offsets": [ [ 49, 53 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O18752" }, { "db_name": "UniProt", "db_id": "O18753" }, { "db_name": "UniProt", "db_id": "O18755" }, { "db_name": "UniProt", "db_id": "O70183" }, { "db_name": "UniProt", "db_id": "O97759" }, { "db_name": "UniProt", "db_id": "P14082" }, { "db_name": "UniProt", "db_id": "P21237" }, { "db_name": "UniProt", "db_id": "P23363" }, { "db_name": "UniProt", "db_id": "P23560" }, { "db_name": "UniProt", "db_id": "P25429" }, { "db_name": "UniProt", "db_id": "P25430" }, { "db_name": "UniProt", "db_id": "P25431" }, { "db_name": "UniProt", "db_id": "P25432" }, { "db_name": "UniProt", "db_id": "Q02193" }, { "db_name": "UniProt", "db_id": "Q06225" }, { "db_name": "UniProt", "db_id": "Q3SAT7" }, { "db_name": "UniProt", "db_id": "Q4L0Y3" }, { "db_name": "UniProt", "db_id": "Q5IS78" }, { "db_name": "UniProt", "db_id": "Q6LCI5" }, { "db_name": "UniProt", "db_id": "Q7YRB4" }, { "db_name": "UniProt", "db_id": "Q90322" }, { "db_name": "UniProt", "db_id": "Q95106" }, { "db_name": "UniProt", "db_id": "Q9TST3" } ] }, { "id": "DS.d626.s1.e0", "type": "compound", "text": [ "ziprasidone" ], "offsets": [ [ 96, 107 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "60854" } ] }, { "id": "DS.d626.s1.e1", "type": "protein", "text": [ "BDNF" ], "offsets": [ [ 179, 183 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O18752" }, { "db_name": "UniProt", "db_id": "O18753" }, { "db_name": "UniProt", "db_id": "O18755" }, { "db_name": "UniProt", "db_id": "O70183" }, { "db_name": "UniProt", "db_id": "O97759" }, { "db_name": "UniProt", "db_id": "P14082" }, { "db_name": "UniProt", "db_id": "P21237" }, { "db_name": "UniProt", "db_id": "P23363" }, { "db_name": "UniProt", "db_id": "P23560" }, { "db_name": "UniProt", "db_id": "P25429" }, { "db_name": "UniProt", "db_id": "P25430" }, { "db_name": "UniProt", "db_id": "P25431" }, { "db_name": "UniProt", "db_id": "P25432" }, { "db_name": "UniProt", "db_id": "Q02193" }, { "db_name": "UniProt", "db_id": "Q06225" }, { "db_name": "UniProt", "db_id": "Q3SAT7" }, { "db_name": "UniProt", "db_id": "Q4L0Y3" }, { "db_name": "UniProt", "db_id": "Q5IS78" }, { "db_name": "UniProt", "db_id": "Q6LCI5" }, { "db_name": "UniProt", "db_id": "Q7YRB4" }, { "db_name": "UniProt", "db_id": "Q90322" }, { "db_name": "UniProt", "db_id": "Q95106" }, { "db_name": "UniProt", "db_id": "Q9TST3" } ] }, { "id": "DS.d626.s2.e0", "type": "compound", "text": [ "Ziprasidone" ], "offsets": [ [ 191, 202 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "60854" } ] }, { "id": "DS.d626.s2.e1", "type": "protein", "text": [ "BDNF" ], "offsets": [ [ 237, 241 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O18752" }, { "db_name": "UniProt", "db_id": "O18753" }, { "db_name": "UniProt", "db_id": "O18755" }, { "db_name": "UniProt", "db_id": "O70183" }, { "db_name": "UniProt", "db_id": "O97759" }, { "db_name": "UniProt", "db_id": "P14082" }, { "db_name": "UniProt", "db_id": "P21237" }, { "db_name": "UniProt", "db_id": "P23363" }, { "db_name": "UniProt", "db_id": "P23560" }, { "db_name": "UniProt", "db_id": "P25429" }, { "db_name": "UniProt", "db_id": "P25430" }, { "db_name": "UniProt", "db_id": "P25431" }, { "db_name": "UniProt", "db_id": "P25432" }, { "db_name": "UniProt", "db_id": "Q02193" }, { "db_name": "UniProt", "db_id": "Q06225" }, { "db_name": "UniProt", "db_id": "Q3SAT7" }, { "db_name": "UniProt", "db_id": "Q4L0Y3" }, { "db_name": "UniProt", "db_id": "Q5IS78" }, { "db_name": "UniProt", "db_id": "Q6LCI5" }, { "db_name": "UniProt", "db_id": "Q7YRB4" }, { "db_name": "UniProt", "db_id": "Q90322" }, { "db_name": "UniProt", "db_id": "Q95106" }, { "db_name": "UniProt", "db_id": "Q9TST3" } ] }, { "id": "DS.d626.s3.e0", "type": "compound", "text": [ "ziprasidone" ], "offsets": [ [ 323, 334 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "60854" } ] }, { "id": "DS.d626.s3.e1", "type": "protein", "text": [ "BDNF" ], "offsets": [ [ 413, 417 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O18752" }, { "db_name": "UniProt", "db_id": "O18753" }, { "db_name": "UniProt", "db_id": "O18755" }, { "db_name": "UniProt", "db_id": "O70183" }, { "db_name": "UniProt", "db_id": "O97759" }, { "db_name": "UniProt", "db_id": "P14082" }, { "db_name": "UniProt", "db_id": "P21237" }, { "db_name": "UniProt", "db_id": "P23363" }, { "db_name": "UniProt", "db_id": "P23560" }, { "db_name": "UniProt", "db_id": "P25429" }, { "db_name": "UniProt", "db_id": "P25430" }, { "db_name": "UniProt", "db_id": "P25431" }, { "db_name": "UniProt", "db_id": "P25432" }, { "db_name": "UniProt", "db_id": "Q02193" }, { "db_name": "UniProt", "db_id": "Q06225" }, { "db_name": "UniProt", "db_id": "Q3SAT7" }, { "db_name": "UniProt", "db_id": "Q4L0Y3" }, { "db_name": "UniProt", "db_id": "Q5IS78" }, { "db_name": "UniProt", "db_id": "Q6LCI5" }, { "db_name": "UniProt", "db_id": "Q7YRB4" }, { "db_name": "UniProt", "db_id": "Q90322" }, { "db_name": "UniProt", "db_id": "Q95106" }, { "db_name": "UniProt", "db_id": "Q9TST3" } ] } ]
[]
[]
[ { "id": "DS.d626.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d626.s0.e0", "arg2_id": "DS.d626.s0.e1", "normalized": [] }, { "id": "DS.d626.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d626.s1.e0", "arg2_id": "DS.d626.s1.e1", "normalized": [] }, { "id": "DS.d626.s2.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d626.s2.e0", "arg2_id": "DS.d626.s2.e1", "normalized": [] }, { "id": "DS.d626.s3.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d626.s3.e0", "arg2_id": "DS.d626.s3.e1", "normalized": [] } ]
DS.d627
18657000
[ { "id": "DS.d627.s0", "type": "", "text": [ "In conclusion, fructose overload in rats induced hypertriglyceridemia and insulin resistance associated with an enhanced oxidative stress." ], "offsets": [ [ 0, 138 ] ] } ]
[ { "id": "DS.d627.s0.e0", "type": "compound", "text": [ "fructose" ], "offsets": [ [ 15, 23 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5984" } ] }, { "id": "DS.d627.s0.e1", "type": "protein", "text": [ "insulin" ], "offsets": [ [ 74, 81 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01314" }, { "db_name": "UniProt", "db_id": "P01316" }, { "db_name": "UniProt", "db_id": "P01319" }, { "db_name": "UniProt", "db_id": "P01320" }, { "db_name": "UniProt", "db_id": "P01324" }, { "db_name": "UniProt", "db_id": "P01328" }, { "db_name": "UniProt", "db_id": "P01330" }, { "db_name": "UniProt", "db_id": "P01331" }, { "db_name": "UniProt", "db_id": "P01334" }, { "db_name": "UniProt", "db_id": "P01336" }, { "db_name": "UniProt", "db_id": "P01340" }, { "db_name": "UniProt", "db_id": "P07453" }, { "db_name": "UniProt", "db_id": "P09476" }, { "db_name": "UniProt", "db_id": "P09477" }, { "db_name": "UniProt", "db_id": "P0C236" }, { "db_name": "UniProt", "db_id": "P12703" }, { "db_name": "UniProt", "db_id": "P12704" }, { "db_name": "UniProt", "db_id": "P12708" }, { "db_name": "UniProt", "db_id": "P13190" }, { "db_name": "UniProt", "db_id": "P18109" }, { "db_name": "UniProt", "db_id": "P29335" }, { "db_name": "UniProt", "db_id": "P42633" }, { "db_name": "UniProt", "db_id": "P67968" }, { "db_name": "UniProt", "db_id": "P67969" }, { "db_name": "UniProt", "db_id": "P67971" }, { "db_name": "UniProt", "db_id": "P67973" }, { "db_name": "UniProt", "db_id": "P67974" }, { "db_name": "UniProt", "db_id": "P68243" }, { "db_name": "UniProt", "db_id": "P68245" }, { "db_name": "UniProt", "db_id": "P68987" }, { "db_name": "UniProt", "db_id": "P68988" }, { "db_name": "UniProt", "db_id": "P68989" }, { "db_name": "UniProt", "db_id": "P68990" }, { "db_name": "UniProt", "db_id": "P68991" }, { "db_name": "UniProt", "db_id": "P68992" }, { "db_name": "UniProt", "db_id": "P69046" }, { "db_name": "UniProt", "db_id": "P69047" }, { "db_name": "UniProt", "db_id": "P69048" }, { "db_name": "UniProt", "db_id": "P81423" }, { "db_name": "UniProt", "db_id": "P81881" }, { "db_name": "UniProt", "db_id": "Q9TQY7" } ] } ]
[]
[]
[ { "id": "DS.d627.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d627.s0.e0", "arg2_id": "DS.d627.s0.e1", "normalized": [] } ]
DS.d628
18657005
[ { "id": "DS.d628.s0", "type": "", "text": [ "Clinical and biochemical parameters including fructosamine (FAM), glycated hemoglobin (HbA1c) and serum AGEs were investigated in children and adolescents with 1 type diabetes with (+DC) and without (-DC) complications." ], "offsets": [ [ 0, 219 ] ] } ]
[ { "id": "DS.d628.s0.e0", "type": "compound", "text": [ "fructosamine" ], "offsets": [ [ 46, 58 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "20484" } ] }, { "id": "DS.d628.s0.e1", "type": "protein", "text": [ "hemoglobin" ], "offsets": [ [ 75, 85 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P15160" }, { "db_name": "UniProt", "db_id": "P17724" }, { "db_name": "UniProt", "db_id": "P73925" }, { "db_name": "UniProt", "db_id": "Q03459" } ] }, { "id": "DS.d628.s0.e2", "type": "protein", "text": [ "AGEs" ], "offsets": [ [ 104, 108 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O18921" }, { "db_name": "UniProt", "db_id": "P17560" }, { "db_name": "UniProt", "db_id": "P51606" }, { "db_name": "UniProt", "db_id": "P51607" }, { "db_name": "UniProt", "db_id": "P82343" } ] } ]
[]
[]
[]
DS.d629
18657007
[ { "id": "DS.d629.s0", "type": "", "text": [ "Leptin and soluble leptin receptor changes after pulmonary endarterectomy: relations to cortisol and cytokine network." ], "offsets": [ [ 0, 118 ] ] }, { "id": "DS.d629.s1", "type": "", "text": [ "Leptin and soluble leptin receptor (SLR) were compared with evolution of cortisol and inflammatory cytokines in twenty-two patients with chronic thromboembolic pulmonary hypertension treated with pulmonary endarterectomy using cardiopulmonary bypass (CBP) and deep hypothermic circulatory arrest (DHCA)." ], "offsets": [ [ 119, 422 ] ] } ]
[ { "id": "DS.d629.s0.e0", "type": "protein", "text": [ "Leptin" ], "offsets": [ [ 0, 6 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O02750" }, { "db_name": "UniProt", "db_id": "O93416" }, { "db_name": "UniProt", "db_id": "Q28603" }, { "db_name": "UniProt", "db_id": "Q95189" }, { "db_name": "UniProt", "db_id": "Q95234" } ] }, { "id": "DS.d629.s0.e1", "type": "protein", "text": [ "leptin" ], "offsets": [ [ 19, 25 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O02750" }, { "db_name": "UniProt", "db_id": "O93416" }, { "db_name": "UniProt", "db_id": "Q28603" }, { "db_name": "UniProt", "db_id": "Q95189" }, { "db_name": "UniProt", "db_id": "Q95234" } ] }, { "id": "DS.d629.s0.e2", "type": "compound", "text": [ "cortisol" ], "offsets": [ [ 88, 96 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5754" } ] }, { "id": "DS.d629.s1.e0", "type": "protein", "text": [ "Leptin" ], "offsets": [ [ 119, 125 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O02750" }, { "db_name": "UniProt", "db_id": "O93416" }, { "db_name": "UniProt", "db_id": "Q28603" }, { "db_name": "UniProt", "db_id": "Q95189" }, { "db_name": "UniProt", "db_id": "Q95234" } ] }, { "id": "DS.d629.s1.e1", "type": "protein", "text": [ "leptin" ], "offsets": [ [ 138, 144 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O02750" }, { "db_name": "UniProt", "db_id": "O93416" }, { "db_name": "UniProt", "db_id": "Q28603" }, { "db_name": "UniProt", "db_id": "Q95189" }, { "db_name": "UniProt", "db_id": "Q95234" } ] }, { "id": "DS.d629.s1.e2", "type": "compound", "text": [ "cortisol" ], "offsets": [ [ 192, 200 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5754" } ] } ]
[]
[]
[ { "id": "DS.d629.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d629.s0.e2", "arg2_id": "DS.d629.s0.e1", "normalized": [] }, { "id": "DS.d629.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d629.s0.e2", "arg2_id": "DS.d629.s0.e0", "normalized": [] } ]
DS.d630
18657009
[ { "id": "DS.d630.s0", "type": "", "text": [ "Using this method, we also determined whether streptozotocin-induced DM in rats (4-week duration) leads to changes in renal subcellular targeting of CAV-1, and evaluated the effects of tight metabolic control (insulin, 12 IU/day) and angiotensin receptor blocker, losartan (4 weeks, 20 mg/kg/day)." ], "offsets": [ [ 0, 297 ] ] } ]
[ { "id": "DS.d630.s0.e0", "type": "protein", "text": [ "CAV-1" ], "offsets": [ [ 149, 154 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q9YGM8" } ] }, { "id": "DS.d630.s0.e1", "type": "protein", "text": [ "insulin" ], "offsets": [ [ 210, 217 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01314" }, { "db_name": "UniProt", "db_id": "P01316" }, { "db_name": "UniProt", "db_id": "P01319" }, { "db_name": "UniProt", "db_id": "P01320" }, { "db_name": "UniProt", "db_id": "P01324" }, { "db_name": "UniProt", "db_id": "P01328" }, { "db_name": "UniProt", "db_id": "P01330" }, { "db_name": "UniProt", "db_id": "P01331" }, { "db_name": "UniProt", "db_id": "P01334" }, { "db_name": "UniProt", "db_id": "P01336" }, { "db_name": "UniProt", "db_id": "P01340" }, { "db_name": "UniProt", "db_id": "P07453" }, { "db_name": "UniProt", "db_id": "P09476" }, { "db_name": "UniProt", "db_id": "P09477" }, { "db_name": "UniProt", "db_id": "P0C236" }, { "db_name": "UniProt", "db_id": "P12703" }, { "db_name": "UniProt", "db_id": "P12704" }, { "db_name": "UniProt", "db_id": "P12708" }, { "db_name": "UniProt", "db_id": "P13190" }, { "db_name": "UniProt", "db_id": "P18109" }, { "db_name": "UniProt", "db_id": "P29335" }, { "db_name": "UniProt", "db_id": "P42633" }, { "db_name": "UniProt", "db_id": "P67968" }, { "db_name": "UniProt", "db_id": "P67969" }, { "db_name": "UniProt", "db_id": "P67971" }, { "db_name": "UniProt", "db_id": "P67973" }, { "db_name": "UniProt", "db_id": "P67974" }, { "db_name": "UniProt", "db_id": "P68243" }, { "db_name": "UniProt", "db_id": "P68245" }, { "db_name": "UniProt", "db_id": "P68987" }, { "db_name": "UniProt", "db_id": "P68988" }, { "db_name": "UniProt", "db_id": "P68989" }, { "db_name": "UniProt", "db_id": "P68990" }, { "db_name": "UniProt", "db_id": "P68991" }, { "db_name": "UniProt", "db_id": "P68992" }, { "db_name": "UniProt", "db_id": "P69046" }, { "db_name": "UniProt", "db_id": "P69047" }, { "db_name": "UniProt", "db_id": "P69048" }, { "db_name": "UniProt", "db_id": "P81423" }, { "db_name": "UniProt", "db_id": "P81881" }, { "db_name": "UniProt", "db_id": "Q9TQY7" } ] }, { "id": "DS.d630.s0.e2", "type": "compound", "text": [ "losartan" ], "offsets": [ [ 264, 272 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "3961" } ] } ]
[]
[]
[]
DS.d631
18657194
[ { "id": "DS.d631.s0", "type": "", "text": [ "Androgenic action correlates inversely with a polymorphic CAG repeat region in the AR gene encoding for glutamine residues the length of which appears to influence high density lipoprotein (HDL) cholesterol levels." ], "offsets": [ [ 0, 214 ] ] } ]
[ { "id": "DS.d631.s0.e0", "type": "compound", "text": [ "glutamine" ], "offsets": [ [ 104, 113 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "738" }, { "db_name": "PubChem", "db_id": "5961" } ] }, { "id": "DS.d631.s0.e1", "type": "protein", "text": [ "high density lipoprotein" ], "offsets": [ [ 164, 188 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P81182" } ] }, { "id": "DS.d631.s0.e2", "type": "compound", "text": [ "cholesterol" ], "offsets": [ [ 195, 206 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "304" }, { "db_name": "PubChem", "db_id": "5997" }, { "db_name": "PubChem", "db_id": "6432564" }, { "db_name": "PubChem", "db_id": "11025495" } ] } ]
[]
[]
[ { "id": "DS.d631.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d631.s0.e2", "arg2_id": "DS.d631.s0.e1", "normalized": [] }, { "id": "DS.d631.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d631.s0.e0", "arg2_id": "DS.d631.s0.e1", "normalized": [] } ]
DS.d632
18657228
[ { "id": "DS.d632.s0", "type": "", "text": [ "These vessels are formed by proliferating cells that incorporate bromodeoxyuridine and express the endothelial cell markers vegfr2/kdr and fli1." ], "offsets": [ [ 0, 144 ] ] }, { "id": "DS.d632.s1", "type": "", "text": [ "Moreover, similar to rFGF2, injection of the zebrafish form of vascular endothelial growth factor-A (VEGF-A) induces a significant angiogenic response in the ZFYM assay that is suppressed by the VEGF receptor-2/KDR TK inhibitor SU5416." ], "offsets": [ [ 145, 380 ] ] } ]
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[]
[]
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DS.d633
18657961
[ { "id": "DS.d633.s0", "type": "", "text": [ "In this study, we examined ferulate for its ability to suppress redox-sensitive, proinflammatory NF-kappaB activation via NF-kappaB-inducing kinase (NIK)/IkappaB kinase (IKK) and mitogen-activated protein kinases (MAPKs) by reducing oxidative stress in aged rats." ], "offsets": [ [ 0, 263 ] ] }, { "id": "DS.d633.s1", "type": "", "text": [ "Data show that in aged kidney tissue, ferulate exhibited its antioxidative action by maintaining redox regulation, suppressing NF-kappaB activation and modulating the expression of NF-kappaB-induced, proinflammatory COX-2, iNOS, VCAM-1 and ICAM-1." ], "offsets": [ [ 264, 511 ] ] }, { "id": "DS.d633.s2", "type": "", "text": [ "The molecular modulation of NF-kappaB by ferulate was further revealed in endothelial YPEN-1 cells through ferulate's ability to suppress the activation of NIK/IKK and MAPKs." ], "offsets": [ [ 512, 686 ] ] }, { "id": "DS.d633.s3", "type": "", "text": [ "Based on these results, we conclude that ferulate's antioxidative capacity suppressed the age-related increase in NF-kappaB activity through inhibition of NIK/IKK and MAPKs in vivo." ], "offsets": [ [ 687, 868 ] ] } ]
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[]
[]
[ { "id": "DS.d633.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d633.s0.e0", "arg2_id": "DS.d633.s0.e2", "normalized": [] }, { "id": "DS.d633.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d633.s0.e0", "arg2_id": "DS.d633.s0.e3", "normalized": [] }, { "id": "DS.d633.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d633.s0.e0", "arg2_id": "DS.d633.s0.e4", "normalized": [] }, { "id": "DS.d633.s0.i3", "type": "compound-protein-interaction", "arg1_id": "DS.d633.s0.e0", "arg2_id": "DS.d633.s0.e1", "normalized": [] }, { "id": "DS.d633.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d633.s1.e0", "arg2_id": "DS.d633.s1.e1", "normalized": [] }, { "id": "DS.d633.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d633.s1.e0", "arg2_id": "DS.d633.s1.e3", "normalized": [] }, { "id": "DS.d633.s1.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d633.s1.e0", "arg2_id": "DS.d633.s1.e2", "normalized": [] }, { "id": "DS.d633.s1.i3", "type": "compound-protein-interaction", "arg1_id": "DS.d633.s1.e0", "arg2_id": "DS.d633.s1.e4", "normalized": [] }, { "id": "DS.d633.s2.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d633.s2.e0", "arg2_id": "DS.d633.s2.e2", "normalized": [] }, { "id": "DS.d633.s2.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d633.s2.e0", "arg2_id": "DS.d633.s2.e3", "normalized": [] }, { "id": "DS.d633.s3.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d633.s3.e0", "arg2_id": "DS.d633.s3.e1", "normalized": [] }, { "id": "DS.d633.s3.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d633.s3.e0", "arg2_id": "DS.d633.s3.e2", "normalized": [] } ]
DS.d634
18658095
[ { "id": "DS.d634.s0", "type": "", "text": [ "Previous studies have shown that wounding of human corneal epithelial cells (HCECs) results in the release of G-protein-coupled receptor ligands such as ATP and lysophosphatidic acid (LPA), which in turn transactivate epidermal growth factor (EGF) receptor (EGFR) through ectodomain shedding of heparin-binding EGF-like growth factor (HB-EGF)." ], "offsets": [ [ 0, 343 ] ] } ]
[ { "id": "DS.d634.s0.e0", "type": "compound", "text": [ "ATP" ], "offsets": [ [ 153, 156 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5957" } ] }, { "id": "DS.d634.s0.e1", "type": "compound", "text": [ "lysophosphatidic acid" ], "offsets": [ [ 161, 182 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "3988" }, { "db_name": "PubChem", "db_id": "5311263" }, { "db_name": "PubChem", "db_id": "5497152" } ] }, { "id": "DS.d634.s0.e2", "type": "protein", "text": [ "epidermal growth factor" ], "offsets": [ [ 218, 241 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01132" }, { "db_name": "UniProt", "db_id": "P01133" }, { "db_name": "UniProt", "db_id": "P07522" }, { "db_name": "UniProt", "db_id": "Q00968" }, { "db_name": "UniProt", "db_id": "Q95ND4" }, { "db_name": "UniProt", "db_id": "Q9BEA0" } ] }, { "id": "DS.d634.s0.e3", "type": "protein", "text": [ "EGF" ], "offsets": [ [ 243, 246 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01132" }, { "db_name": "UniProt", "db_id": "P01133" }, { "db_name": "UniProt", "db_id": "P07522" }, { "db_name": "UniProt", "db_id": "P26224" }, { "db_name": "UniProt", "db_id": "Q00968" }, { "db_name": "UniProt", "db_id": "Q95ND4" }, { "db_name": "UniProt", "db_id": "Q9BEA0" } ] }, { "id": "DS.d634.s0.e4", "type": "protein", "text": [ "EGFR" ], "offsets": [ [ 258, 262 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P00533" }, { "db_name": "UniProt", "db_id": "P13387" }, { "db_name": "UniProt", "db_id": "P55245" } ] }, { "id": "DS.d634.s0.e5", "type": "protein", "text": [ "EGF" ], "offsets": [ [ 258, 261 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01132" }, { "db_name": "UniProt", "db_id": "P01133" }, { "db_name": "UniProt", "db_id": "P07522" }, { "db_name": "UniProt", "db_id": "P26224" }, { "db_name": "UniProt", "db_id": "Q00968" }, { "db_name": "UniProt", "db_id": "Q95ND4" }, { "db_name": "UniProt", "db_id": "Q9BEA0" } ] }, { "id": "DS.d634.s0.e6", "type": "protein", "text": [ "HB-EGF" ], "offsets": [ [ 335, 341 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q01580" }, { "db_name": "UniProt", "db_id": "Q06175" }, { "db_name": "UniProt", "db_id": "Q06186" }, { "db_name": "UniProt", "db_id": "Q09118" }, { "db_name": "UniProt", "db_id": "Q99075" } ] } ]
[]
[]
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DS.d635
18660796
[ { "id": "DS.d635.s0", "type": "", "text": [ "Nitric oxide is a free radical molecule synthesized from L-arginine by nitric oxide synthases that plays a critical role in various physiological and pathological processes, including tumor growth and angiogenesis." ], "offsets": [ [ 0, 214 ] ] } ]
[ { "id": "DS.d635.s0.e0", "type": "compound", "text": [ "Nitric oxide" ], "offsets": [ [ 0, 12 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "145068" } ] }, { "id": "DS.d635.s0.e1", "type": "compound", "text": [ "L-arginine" ], "offsets": [ [ 57, 67 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6322" } ] }, { "id": "DS.d635.s0.e2", "type": "protein", "text": [ "nitric oxide synthases" ], "offsets": [ [ 71, 93 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O61309" }, { "db_name": "UniProt", "db_id": "O61608" }, { "db_name": "UniProt", "db_id": "Q27571" }, { "db_name": "UniProt", "db_id": "Q9I9M2" } ] } ]
[]
[]
[ { "id": "DS.d635.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d635.s0.e0", "arg2_id": "DS.d635.s0.e2", "normalized": [] }, { "id": "DS.d635.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d635.s0.e1", "arg2_id": "DS.d635.s0.e2", "normalized": [] } ]
DS.d636
18661133
[ { "id": "DS.d636.s0", "type": "", "text": [ "Furthermore, restoration of KSR1 expression in KSR (-/-) MEFs following stable transduction of cells with a KSR1 expression vector, enhanced sensitivity of cells to tunicamycin and cytochalasin H and decreased ERK1/2 activation following exposure to these drugs." ], "offsets": [ [ 0, 262 ] ] } ]
[ { "id": "DS.d636.s0.e0", "type": "protein", "text": [ "KSR1" ], "offsets": [ [ 28, 32 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q8IVT5" } ] }, { "id": "DS.d636.s0.e1", "type": "protein", "text": [ "KSR1" ], "offsets": [ [ 108, 112 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q8IVT5" } ] }, { "id": "DS.d636.s0.e2", "type": "compound", "text": [ "cytochalasin H" ], "offsets": [ [ 181, 195 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5351303" }, { "db_name": "PubChem", "db_id": "6434468" }, { "db_name": "PubChem", "db_id": "13892272" }, { "db_name": "PubChem", "db_id": "17751001" } ] }, { "id": "DS.d636.s0.e3", "type": "protein", "text": [ "ERK1" ], "offsets": [ [ 210, 214 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P27361" }, { "db_name": "UniProt", "db_id": "P28869" }, { "db_name": "UniProt", "db_id": "P42525" }, { "db_name": "UniProt", "db_id": "Q07176" } ] } ]
[]
[]
[ { "id": "DS.d636.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d636.s0.e2", "arg2_id": "DS.d636.s0.e0", "normalized": [] } ]
DS.d638
18661233
[ { "id": "DS.d638.s0", "type": "", "text": [ "We demonstrated the increase in the levels of p53, Bax, and cytochrome c and decrease in the level of Bcl-2, which are associated with the induction of apoptotic cell death after 24 h treatment with baicalein in N18 cells." ], "offsets": [ [ 0, 222 ] ] } ]
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"text": [ "baicalein" ], "offsets": [ [ 199, 208 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5281605" } ] } ]
[]
[]
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DS.d639
18661547
[ { "id": "DS.d639.s0", "type": "", "text": [ "GFP-fluorescent cells were slowly cycling, as shown by their long-term retention of BrdU, and less than 10% expressed the proliferative markers Ki67 and Mcm2." ], "offsets": [ [ 0, 158 ] ] } ]
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[]
[]
[]
DS.d640
18662278
[ { "id": "DS.d640.s0", "type": "", "text": [ "MTHFR gene polymorphisms and high levels of homocysteine are associated with a high degree of steatosis and fibrosis, conditions associated with a low sustained virological response (SVR) rate." ], "offsets": [ [ 0, 193 ] ] } ]
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[]
[]
[]
DS.d641
18662930
[ { "id": "DS.d641.s0", "type": "", "text": [ "Hyaluronan inhibits expression of ADAMTS4 (aggrecanase-1) in human osteoarthritic chondrocytes." ], "offsets": [ [ 0, 95 ] ] } ]
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[]
[]
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DS.d642
18663366
[ { "id": "DS.d642.s0", "type": "", "text": [ "The discovery that a common polymorphism (5-HTTLPR, short variant) in the human serotonin transporter gene (SLC6A4) can influence personality traits and increase the risk for depression in adulthood has led to the hypothesis that a relative increase in the extracellular levels of serotonin (5-HT) during development could be critical for the establishment of brain circuits." ], "offsets": [ [ 0, 375 ] ] } ]
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[]
[]
[]
DS.d643
18663367
[ { "id": "DS.d643.s0", "type": "", "text": [ "Besides the biogenesis of lysosome-related organelles complex 1 and dystrophin-associated protein complex, several molecules in the DTNBP1 network likely provide insight into the role of DTNBP1 in biological systems: retinoic acid, beta-estradiol, calmodulin and tumour necrosis factor." ], "offsets": [ [ 0, 286 ] ] } ]
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DS.d644
18663553
[ { "id": "DS.d644.s0", "type": "", "text": [ "Prior to the first dose of leflunomide, serum concentrations of studied chemokines correlated with marker of RA activity such as the erythrocyte sedimentation rate and IL-8 level with DAS." ], "offsets": [ [ 0, 188 ] ] } ]
[ { "id": "DS.d644.s0.e0", "type": "compound", "text": [ "leflunomide" ], "offsets": [ [ 27, 38 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "3899" } ] }, { "id": "DS.d644.s0.e1", "type": "protein", "text": [ "IL-8" ], "offsets": [ [ 168, 172 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O62812" }, { "db_name": "UniProt", "db_id": "P08317" }, { "db_name": "UniProt", "db_id": "P10145" }, { "db_name": "UniProt", "db_id": "P19874" }, { "db_name": "UniProt", "db_id": "P26894" }, { "db_name": "UniProt", "db_id": "P36925" }, { "db_name": "UniProt", "db_id": "P41324" }, { "db_name": "UniProt", "db_id": "P46653" }, { "db_name": "UniProt", "db_id": "P49113" }, { "db_name": "UniProt", "db_id": "P67813" }, { "db_name": "UniProt", "db_id": "P67814" }, { "db_name": "UniProt", "db_id": "P79255" }, { "db_name": "UniProt", "db_id": "Q102R3" }, { "db_name": "UniProt", "db_id": "Q7YRB5" }, { "db_name": "UniProt", "db_id": "Q9XSX5" } ] } ]
[]
[]
[]
DS.d645
18663559
[ { "id": "DS.d645.s0", "type": "", "text": [ "Hypothetically, cytochrome P450 2D6 influences the transport of taurine across the blood-brain barrier." ], "offsets": [ [ 0, 103 ] ] } ]
[ { "id": "DS.d645.s0.e0", "type": "protein", "text": [ "cytochrome P450 2D6" ], "offsets": [ [ 16, 35 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P10635" }, { "db_name": "UniProt", "db_id": "Q2XNC8" }, { "db_name": "UniProt", "db_id": "Q2XNC9" } ] }, { "id": "DS.d645.s0.e1", "type": "compound", "text": [ "taurine" ], "offsets": [ [ 64, 71 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1123" } ] } ]
[]
[]
[ { "id": "DS.d645.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d645.s0.e1", "arg2_id": "DS.d645.s0.e0", "normalized": [] } ]
DS.d646
18663659
[ { "id": "DS.d646.s0", "type": "", "text": [ "Most genes involved in lipid metabolism and especially in ergosterol biosynthesis were up-regulated in response to itraconazole, including ERG6, ERG7, ERG11, ERG24, ERG25 and ERG26." ], "offsets": [ [ 0, 181 ] ] } ]
[ { "id": "DS.d646.s0.e0", "type": "compound", "text": [ "itraconazole" ], "offsets": [ [ 115, 127 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "3793" }, { "db_name": "PubChem", "db_id": "55283" }, { "db_name": "PubChem", "db_id": "6917738" }, { "db_name": "PubChem", "db_id": "14179013" } ] }, { "id": "DS.d646.s0.e1", "type": "protein", "text": [ "ERG6" ], "offsets": [ [ 139, 143 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O74198" }, { "db_name": "UniProt", "db_id": "P25087" }, { "db_name": "UniProt", "db_id": "Q5EN22" }, { "db_name": "UniProt", "db_id": "Q6BRB7" }, { "db_name": "UniProt", "db_id": "Q6C2D9" }, { "db_name": "UniProt", "db_id": "Q6CYB3" }, { "db_name": "UniProt", "db_id": "Q6FRZ7" }, { "db_name": "UniProt", "db_id": "Q759S7" }, { "db_name": "UniProt", "db_id": "Q875K1" } ] }, { "id": "DS.d646.s0.e2", "type": "protein", "text": [ "ERG7" ], "offsets": [ [ 145, 149 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P38604" }, { "db_name": "UniProt", "db_id": "Q04782" }, { "db_name": "UniProt", "db_id": "Q96WJ0" } ] }, { "id": "DS.d646.s0.e3", "type": "protein", "text": [ "ERG11" ], "offsets": [ [ 151, 156 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P10613" }, { "db_name": "UniProt", "db_id": "P10614" }, { "db_name": "UniProt", "db_id": "P14263" }, { "db_name": "UniProt", "db_id": "P49602" }, { "db_name": "UniProt", "db_id": "P50859" }, { "db_name": "UniProt", "db_id": "Q759W0" } ] }, { "id": "DS.d646.s0.e4", "type": "protein", "text": [ "ERG24" ], "offsets": [ [ 158, 163 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P32462" } ] }, { "id": "DS.d646.s0.e5", "type": "protein", "text": [ "ERG25" ], "offsets": [ [ 165, 170 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O59933" }, { "db_name": "UniProt", "db_id": "P53045" }, { "db_name": "UniProt", "db_id": "Q15800" } ] }, { "id": "DS.d646.s0.e6", "type": "protein", "text": [ "ERG26" ], "offsets": [ [ 175, 180 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P53199" } ] } ]
[]
[]
[ { "id": "DS.d646.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d646.s0.e0", "arg2_id": "DS.d646.s0.e2", "normalized": [] }, { "id": "DS.d646.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d646.s0.e0", "arg2_id": "DS.d646.s0.e3", "normalized": [] }, { "id": "DS.d646.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d646.s0.e0", "arg2_id": "DS.d646.s0.e1", "normalized": [] }, { "id": "DS.d646.s0.i3", "type": "compound-protein-interaction", "arg1_id": "DS.d646.s0.e0", "arg2_id": "DS.d646.s0.e5", "normalized": [] }, { "id": "DS.d646.s0.i4", "type": "compound-protein-interaction", "arg1_id": "DS.d646.s0.e0", "arg2_id": "DS.d646.s0.e6", "normalized": [] }, { "id": "DS.d646.s0.i5", "type": "compound-protein-interaction", "arg1_id": "DS.d646.s0.e0", "arg2_id": "DS.d646.s0.e4", "normalized": [] } ]
DS.d647
18665046
[ { "id": "DS.d647.s0", "type": "", "text": [ "In prolonged OJ with LPS administration, hepatocyte apoptosis depending on Fas ligand expression significantly increased in association with a decrease in ATP contents, thus resulting in liver necrapoptosis." ], "offsets": [ [ 0, 207 ] ] } ]
[ { "id": "DS.d647.s0.e0", "type": "protein", "text": [ "Fas ligand" ], "offsets": [ [ 75, 85 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P36940" }, { "db_name": "UniProt", "db_id": "P41047" }, { "db_name": "UniProt", "db_id": "P48023" }, { "db_name": "UniProt", "db_id": "P63306" }, { "db_name": "UniProt", "db_id": "P63307" }, { "db_name": "UniProt", "db_id": "P63308" }, { "db_name": "UniProt", "db_id": "Q861W5" }, { "db_name": "UniProt", "db_id": "Q9BDN1" }, { "db_name": "UniProt", "db_id": "Q9BEA8" } ] }, { "id": "DS.d647.s0.e1", "type": "compound", "text": [ "ATP" ], "offsets": [ [ 155, 158 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5957" } ] } ]
[]
[]
[]
DS.d648
18665051
[ { "id": "DS.d648.s0", "type": "", "text": [ "Administration of ethyl pyruvate to inhibit HMGB1 or anti-RAGE antibody could significantly decrease expression levels of CTLA-4, Foxp3 on Tregs, and IL-10 production after burns." ], "offsets": [ [ 0, 179 ] ] } ]
[ { "id": "DS.d648.s0.e0", "type": "compound", "text": [ "ethyl pyruvate" ], "offsets": [ [ 18, 32 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "12041" } ] }, { "id": "DS.d648.s0.e1", "type": "protein", "text": [ "CTLA-4" ], "offsets": [ [ 122, 128 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P09793" }, { "db_name": "UniProt", "db_id": "P16410" }, { "db_name": "UniProt", "db_id": "P42072" }, { "db_name": "UniProt", "db_id": "Q9MYX7" }, { "db_name": "UniProt", "db_id": "Q9XSI1" } ] }, { "id": "DS.d648.s0.e2", "type": "protein", "text": [ "Foxp3" ], "offsets": [ [ 130, 135 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q99JB6" } ] }, { "id": "DS.d648.s0.e3", "type": "protein", "text": [ "IL-10" ], "offsets": [ [ 150, 155 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O46673" }, { "db_name": "UniProt", "db_id": "O97798" }, { "db_name": "UniProt", "db_id": "P18893" }, { "db_name": "UniProt", "db_id": "P22301" }, { "db_name": "UniProt", "db_id": "P29456" }, { "db_name": "UniProt", "db_id": "P43480" }, { "db_name": "UniProt", "db_id": "P46651" }, { "db_name": "UniProt", "db_id": "P47965" }, { "db_name": "UniProt", "db_id": "P48411" }, { "db_name": "UniProt", "db_id": "P51496" }, { "db_name": "UniProt", "db_id": "P51497" }, { "db_name": "UniProt", "db_id": "P51746" }, { "db_name": "UniProt", "db_id": "P55029" }, { "db_name": "UniProt", "db_id": "P79338" }, { "db_name": "UniProt", "db_id": "Q0Z972" }, { "db_name": "UniProt", "db_id": "Q25BC1" }, { "db_name": "UniProt", "db_id": "Q28374" }, { "db_name": "UniProt", "db_id": "Q29055" }, { "db_name": "UniProt", "db_id": "Q29408" }, { "db_name": "UniProt", "db_id": "Q2PE73" }, { "db_name": "UniProt", "db_id": "Q5Q0V6" }, { "db_name": "UniProt", "db_id": "Q865X4" }, { "db_name": "UniProt", "db_id": "Q8MKG9" }, { "db_name": "UniProt", "db_id": "Q9JHK7" }, { "db_name": "UniProt", "db_id": "Q9TSJ4" }, { "db_name": "UniProt", "db_id": "Q9Z1Y5" } ] } ]
[]
[]
[ { "id": "DS.d648.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d648.s0.e0", "arg2_id": "DS.d648.s0.e2", "normalized": [] }, { "id": "DS.d648.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d648.s0.e0", "arg2_id": "DS.d648.s0.e3", "normalized": [] }, { "id": "DS.d648.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d648.s0.e0", "arg2_id": "DS.d648.s0.e1", "normalized": [] } ]
DS.d649
18665052
[ { "id": "DS.d649.s0", "type": "", "text": [ "In contrast, the degree of (1) spinal cord inflammation and tissue injury (histological score), (2) nitrotyrosine and poly(adenosine diphosphate (ADP) ribose) formation, (3) iNOS expression, (4) nuclear factor-kappaB activation, and (5) apoptosis (terminal deoxynucleotidyltransferase-mediated dUTP-biotin end labeling, Bax, and Bcl-2) was markedly reduced in spinal cord tissue obtained from mice treated with glycyrrhizin extract (10 mg/kg, i.p., 30 min before and 1 and 6 h after SCI)." ], "offsets": [ [ 0, 488 ] ] } ]
[ { "id": "DS.d649.s0.e0", "type": "compound", "text": [ "adenosine diphosphate" ], "offsets": [ [ 123, 144 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6022" } ] }, { "id": "DS.d649.s0.e1", "type": "protein", "text": [ "iNOS" ], "offsets": [ [ 174, 178 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O19114" }, { "db_name": "UniProt", "db_id": "O46660" }, { "db_name": "UniProt", "db_id": "O54705" }, { "db_name": "UniProt", "db_id": "O62699" }, { "db_name": "UniProt", "db_id": "P29477" }, { "db_name": "UniProt", "db_id": "P35228" }, { "db_name": "UniProt", "db_id": "P79290" }, { "db_name": "UniProt", "db_id": "Q06518" }, { "db_name": "UniProt", "db_id": "Q27995" }, { "db_name": "UniProt", "db_id": "Q28314" }, { "db_name": "UniProt", "db_id": "Q90703" }, { "db_name": "UniProt", "db_id": "Q92037" }, { "db_name": "UniProt", "db_id": "Q92091" } ] }, { "id": "DS.d649.s0.e2", "type": "protein", "text": [ "terminal deoxynucleotidyltransferase" ], "offsets": [ [ 248, 284 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O02789" }, { "db_name": "UniProt", "db_id": "O57486" }, { "db_name": "UniProt", "db_id": "P04053" }, { "db_name": "UniProt", "db_id": "P06526" }, { "db_name": "UniProt", "db_id": "P09838" }, { "db_name": "UniProt", "db_id": "P36195" }, { "db_name": "UniProt", "db_id": "P42118" }, { "db_name": "UniProt", "db_id": "Q92089" } ] }, { "id": "DS.d649.s0.e3", "type": "protein", "text": [ "Bax" ], "offsets": [ [ 320, 323 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P27297" }, { "db_name": "UniProt", "db_id": "Q07813" }, { "db_name": "UniProt", "db_id": "Q63690" } ] }, { "id": "DS.d649.s0.e4", "type": "protein", "text": [ "Bcl-2" ], "offsets": [ [ 329, 334 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P10417" }, { "db_name": "UniProt", "db_id": "P49950" } ] }, { "id": "DS.d649.s0.e5", "type": "compound", "text": [ "glycyrrhizin" ], "offsets": [ [ 411, 423 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "3495" }, { "db_name": "PubChem", "db_id": "14982" }, { "db_name": "PubChem", "db_id": "128229" }, { "db_name": "PubChem", "db_id": "44260118" }, { "db_name": "PubChem", "db_id": "45358130" }, { "db_name": "PubChem", "db_id": "46878350" } ] } ]
[]
[]
[ { "id": "DS.d649.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d649.s0.e5", "arg2_id": "DS.d649.s0.e3", "normalized": [] }, { "id": "DS.d649.s0.i3", "type": "compound-protein-interaction", "arg1_id": "DS.d649.s0.e5", "arg2_id": "DS.d649.s0.e1", "normalized": [] }, { "id": "DS.d649.s0.i6", "type": "compound-protein-interaction", "arg1_id": "DS.d649.s0.e5", "arg2_id": "DS.d649.s0.e2", "normalized": [] }, { "id": "DS.d649.s0.i7", "type": "compound-protein-interaction", "arg1_id": "DS.d649.s0.e5", "arg2_id": "DS.d649.s0.e4", "normalized": [] } ]
DS.d650
18665326
[ { "id": "DS.d650.s0", "type": "", "text": [ "Silymarin attenuated mast cell recruitment thereby decreased the expressions of matrix metalloproteinases-2 and 9 in rat liver carcinogenesis." ], "offsets": [ [ 0, 142 ] ] }, { "id": "DS.d650.s1", "type": "", "text": [ "NDEA administered rats showed increased MCD as revealed by toluidine blue staining along with upregulated expressions of MMP-2 and MMP-9." ], "offsets": [ [ 143, 280 ] ] }, { "id": "DS.d650.s2", "type": "", "text": [ "Silymarin treatment inhibited this increase in MCD and downregulated the expressions of MMP-2 and MMP-9 as revealed by Western blotting and immunohistochemistry." ], "offsets": [ [ 281, 442 ] ] }, { "id": "DS.d650.s3", "type": "", "text": [ "In conclusion, silymarin exerted beneficial effects on liver carcinogenesis by attenuating the recruitment of mast cells and thereby decreased the expressions of MMP-2 and MMP-9." ], "offsets": [ [ 443, 621 ] ] } ]
[ { "id": "DS.d650.s0.e0", "type": "compound", "text": [ "Silymarin" ], "offsets": [ [ 0, 9 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5213" }, { "db_name": "PubChem", "db_id": "31553" }, { "db_name": "PubChem", "db_id": "1548994" }, { "db_name": "PubChem", "db_id": "3086637" }, { "db_name": "PubChem", "db_id": "24832061" }, { "db_name": "PubChem", "db_id": "44147684" } ] }, { "id": "DS.d650.s0.e1", "type": "protein", "text": [ "matrix metalloproteinases-2" ], "offsets": [ [ 80, 107 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P08253" }, { "db_name": "UniProt", "db_id": "P33434" }, { "db_name": "UniProt", "db_id": "P33436" }, { "db_name": "UniProt", "db_id": "P50757" }, { "db_name": "UniProt", "db_id": "Q90611" }, { "db_name": "UniProt", "db_id": "Q9GLE5" } ] }, { "id": "DS.d650.s1.e0", "type": "compound", "text": [ "NDEA" ], "offsets": [ [ 143, 147 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5921" } ] }, { "id": "DS.d650.s1.e1", "type": "protein", "text": [ "MMP-2" ], "offsets": [ [ 264, 269 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P08253" }, { "db_name": "UniProt", "db_id": "P33434" }, { "db_name": "UniProt", "db_id": "P33436" }, { "db_name": "UniProt", "db_id": "P50757" }, { "db_name": "UniProt", "db_id": "Q90611" }, { "db_name": "UniProt", "db_id": "Q9GLE5" } ] }, { "id": "DS.d650.s1.e2", "type": "protein", "text": [ "MMP-9" ], "offsets": [ [ 274, 279 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O18733" }, { "db_name": "UniProt", "db_id": "P14780" }, { "db_name": "UniProt", "db_id": "P41245" }, { "db_name": "UniProt", "db_id": "P41246" }, { "db_name": "UniProt", "db_id": "P50282" }, { "db_name": "UniProt", "db_id": "P52176" } ] }, { "id": "DS.d650.s2.e0", "type": "compound", "text": [ "Silymarin" ], "offsets": [ [ 281, 290 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5213" }, { "db_name": "PubChem", "db_id": "31553" }, { "db_name": "PubChem", "db_id": "1548994" }, { "db_name": "PubChem", "db_id": "3086637" }, { "db_name": "PubChem", "db_id": "24832061" }, { "db_name": "PubChem", "db_id": "44147684" } ] }, { "id": "DS.d650.s2.e1", "type": "protein", "text": [ "MMP-2" ], "offsets": [ [ 369, 374 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P08253" }, { "db_name": "UniProt", "db_id": "P33434" }, { "db_name": "UniProt", "db_id": "P33436" }, { "db_name": "UniProt", "db_id": "P50757" }, { "db_name": "UniProt", "db_id": "Q90611" }, { "db_name": "UniProt", "db_id": "Q9GLE5" } ] }, { "id": "DS.d650.s2.e2", "type": "protein", "text": [ "MMP-9" ], "offsets": [ [ 379, 384 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O18733" }, { "db_name": "UniProt", "db_id": "P14780" }, { "db_name": "UniProt", "db_id": "P41245" }, { "db_name": "UniProt", "db_id": "P41246" }, { "db_name": "UniProt", "db_id": "P50282" }, { "db_name": "UniProt", "db_id": "P52176" } ] }, { "id": "DS.d650.s3.e0", "type": "compound", "text": [ "silymarin" ], "offsets": [ [ 458, 467 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5213" }, { "db_name": "PubChem", "db_id": "31553" }, { "db_name": "PubChem", "db_id": "1548994" }, { "db_name": "PubChem", "db_id": "3086637" }, { "db_name": "PubChem", "db_id": "24832061" }, { "db_name": "PubChem", "db_id": "44147684" } ] }, { "id": "DS.d650.s3.e1", "type": "protein", "text": [ "MMP-2" ], "offsets": [ [ 605, 610 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P08253" }, { "db_name": "UniProt", "db_id": "P33434" }, { "db_name": "UniProt", "db_id": "P33436" }, { "db_name": "UniProt", "db_id": "P50757" }, { "db_name": "UniProt", "db_id": "Q90611" }, { "db_name": "UniProt", "db_id": "Q9GLE5" } ] }, { "id": "DS.d650.s3.e2", "type": "protein", "text": [ "MMP-9" ], "offsets": [ [ 615, 620 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O18733" }, { "db_name": "UniProt", "db_id": "P14780" }, { "db_name": "UniProt", "db_id": "P41245" }, { "db_name": "UniProt", "db_id": "P41246" }, { "db_name": "UniProt", "db_id": "P50282" }, { "db_name": "UniProt", "db_id": "P52176" } ] } ]
[]
[]
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DS.d651
18665390
[ { "id": "DS.d651.s0", "type": "", "text": [ "As a result, combined glucose and insulin infusion significantly decreased plasma K+ concentration despite a significant decrease of urinary K+ excretion in sgk1+/+ but not in sgk1-/-mice." ], "offsets": [ [ 0, 188 ] ] } ]
[ { "id": "DS.d651.s0.e0", "type": "compound", "text": [ "glucose" ], "offsets": [ [ 22, 29 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "206" }, { "db_name": "PubChem", "db_id": "5793" }, { "db_name": "PubChem", "db_id": "64689" }, { "db_name": "PubChem", "db_id": "79025" } ] }, { "id": "DS.d651.s0.e1", "type": "protein", "text": [ "insulin" ], "offsets": [ [ 34, 41 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01314" }, { "db_name": "UniProt", "db_id": "P01316" }, { "db_name": "UniProt", "db_id": "P01319" }, { "db_name": "UniProt", "db_id": "P01320" }, { "db_name": "UniProt", "db_id": "P01324" }, { "db_name": "UniProt", "db_id": "P01328" }, { "db_name": "UniProt", "db_id": "P01330" }, { "db_name": "UniProt", "db_id": "P01331" }, { "db_name": "UniProt", "db_id": "P01334" }, { "db_name": "UniProt", "db_id": "P01336" }, { "db_name": "UniProt", "db_id": "P01340" }, { "db_name": "UniProt", "db_id": "P07453" }, { "db_name": "UniProt", "db_id": "P09476" }, { "db_name": "UniProt", "db_id": "P09477" }, { "db_name": "UniProt", "db_id": "P0C236" }, { "db_name": "UniProt", "db_id": "P12703" }, { "db_name": "UniProt", "db_id": "P12704" }, { "db_name": "UniProt", "db_id": "P12708" }, { "db_name": "UniProt", "db_id": "P13190" }, { "db_name": "UniProt", "db_id": "P18109" }, { "db_name": "UniProt", "db_id": "P29335" }, { "db_name": "UniProt", "db_id": "P42633" }, { "db_name": "UniProt", "db_id": "P67968" }, { "db_name": "UniProt", "db_id": "P67969" }, { "db_name": "UniProt", "db_id": "P67971" }, { "db_name": "UniProt", "db_id": "P67973" }, { "db_name": "UniProt", "db_id": "P67974" }, { "db_name": "UniProt", "db_id": "P68243" }, { "db_name": "UniProt", "db_id": "P68245" }, { "db_name": "UniProt", "db_id": "P68987" }, { "db_name": "UniProt", "db_id": "P68988" }, { "db_name": "UniProt", "db_id": "P68989" }, { "db_name": "UniProt", "db_id": "P68990" }, { "db_name": "UniProt", "db_id": "P68991" }, { "db_name": "UniProt", "db_id": "P68992" }, { "db_name": "UniProt", "db_id": "P69046" }, { "db_name": "UniProt", "db_id": "P69047" }, { "db_name": "UniProt", "db_id": "P69048" }, { "db_name": "UniProt", "db_id": "P81423" }, { "db_name": "UniProt", "db_id": "P81881" }, { "db_name": "UniProt", "db_id": "Q9TQY7" } ] } ]
[]
[]
[]
DS.d652
18665391
[ { "id": "DS.d652.s0", "type": "", "text": [ "While it is clearly demonstrated that members of the TRPC3/6/7 subfamily are activated by diacylglycerol, the mechanism by which phospholipase C activates members of the TRPC1/4/5 subfamily remains a mystery." ], "offsets": [ [ 0, 208 ] ] }, { "id": "DS.d652.s1", "type": "", "text": [ "Depletion of polyphosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate (PIP2) through inhibition of phosphatidylinositol 4-kinase activates calcium entry and membrane currents in TRPC5-expressing but not in TRPC3-or TRPC7-expressing cells." ], "offsets": [ [ 209, 469 ] ] }, { "id": "DS.d652.s2", "type": "", "text": [ "Inclusion of polyphosphatidylinositol 4-phosphate or PIP2, but not phosphatidylinositol 3,4,5-trisphosphate, in the patch pipette inhibited TRPC5 currents." ], "offsets": [ [ 470, 625 ] ] } ]
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[]
[]
[ { "id": "DS.d652.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d652.s0.e1", "arg2_id": "DS.d652.s0.e0", "normalized": [] }, { "id": "DS.d652.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d652.s1.e1", "arg2_id": "DS.d652.s1.e2", "normalized": [] } ]
DS.d653
18665432
[ { "id": "DS.d653.s0", "type": "", "text": [ "Osteogenic differentiation was enhanced after treatment with alendronate as confirmed by Alizarin Red S staining, elevated alkaline phosphatase activity and osteocalcin mRNA expression, a greater calcium peak by energy-dispersive xray spectrophotometry, and by immunofluorescence staining against CD44 by flow cytometric analysis." ], "offsets": [ [ 0, 330 ] ] } ]
[ { "id": "DS.d653.s0.e0", "type": "compound", "text": [ "alendronate" ], "offsets": [ [ 61, 72 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2088" } ] }, { "id": "DS.d653.s0.e1", "type": "protein", "text": [ "alkaline phosphatase" ], "offsets": [ [ 123, 143 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O60109" }, { "db_name": "UniProt", "db_id": "P81800" }, { "db_name": "UniProt", "db_id": "P83456" } ] }, { "id": "DS.d653.s0.e2", "type": "protein", "text": [ "osteocalcin" ], "offsets": [ [ 157, 168 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P02819" }, { "db_name": "UniProt", "db_id": "P02821" }, { "db_name": "UniProt", "db_id": "P02823" }, { "db_name": "UniProt", "db_id": "P0C225" }, { "db_name": "UniProt", "db_id": "P0C226" }, { "db_name": "UniProt", "db_id": "P15504" }, { "db_name": "UniProt", "db_id": "P28317" }, { "db_name": "UniProt", "db_id": "P39056" }, { "db_name": "UniProt", "db_id": "P81455" }, { "db_name": "UniProt", "db_id": "P83005" }, { "db_name": "UniProt", "db_id": "P83238" }, { "db_name": "UniProt", "db_id": "P83473" }, { "db_name": "UniProt", "db_id": "P83489" }, { "db_name": "UniProt", "db_id": "P84348" }, { "db_name": "UniProt", "db_id": "P84349" }, { "db_name": "UniProt", "db_id": "P84350" }, { "db_name": "UniProt", "db_id": "P84351" }, { "db_name": "UniProt", "db_id": "Q7LZI4" }, { "db_name": "UniProt", "db_id": "Q8HYY9" } ] }, { "id": "DS.d653.s0.e3", "type": "protein", "text": [ "CD44" ], "offsets": [ [ 297, 301 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P14745" }, { "db_name": "UniProt", "db_id": "P16070" }, { "db_name": "UniProt", "db_id": "P20944" }, { "db_name": "UniProt", "db_id": "Q05078" }, { "db_name": "UniProt", "db_id": "Q28284" }, { "db_name": "UniProt", "db_id": "Q29423" }, { "db_name": "UniProt", "db_id": "Q60522" } ] } ]
[]
[]
[ { "id": "DS.d653.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d653.s0.e0", "arg2_id": "DS.d653.s0.e2", "normalized": [] }, { "id": "DS.d653.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d653.s0.e0", "arg2_id": "DS.d653.s0.e1", "normalized": [] }, { "id": "DS.d653.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d653.s0.e0", "arg2_id": "DS.d653.s0.e3", "normalized": [] } ]
DS.d654
18667202
[ { "id": "DS.d654.s0", "type": "", "text": [ "Ghrelin inhibits contraction and proliferation of human aortic smooth muscle cells by cAMP/PKA pathway activation." ], "offsets": [ [ 0, 114 ] ] }, { "id": "DS.d654.s1", "type": "", "text": [ "Ghrelin was able to inhibit angiotensin II-induced proliferation and contraction in a dose-response fashion via the cAMP/PKA pathway." ], "offsets": [ [ 115, 248 ] ] } ]
[ { "id": "DS.d654.s0.e0", "type": "protein", "text": [ "Ghrelin" ], "offsets": [ [ 0, 7 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q6BEG6" }, { "db_name": "UniProt", "db_id": "Q6BEG7" }, { "db_name": "UniProt", "db_id": "Q9BDJ6" }, { "db_name": "UniProt", "db_id": "Q9BEF8" }, { "db_name": "UniProt", "db_id": "Q9EQX0" }, { "db_name": "UniProt", "db_id": "Q9GKY5" }, { "db_name": "UniProt", "db_id": "Q9QYH7" }, { "db_name": "UniProt", "db_id": "Q9UBU3" } ] }, { "id": "DS.d654.s0.e1", "type": "compound", "text": [ "cAMP" ], "offsets": [ [ 86, 90 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6076" } ] }, { "id": "DS.d654.s1.e0", "type": "protein", "text": [ "Ghrelin" ], "offsets": [ [ 115, 122 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q6BEG6" }, { "db_name": "UniProt", "db_id": "Q6BEG7" }, { "db_name": "UniProt", "db_id": "Q9BDJ6" }, { "db_name": "UniProt", "db_id": "Q9BEF8" }, { "db_name": "UniProt", "db_id": "Q9EQX0" }, { "db_name": "UniProt", "db_id": "Q9GKY5" }, { "db_name": "UniProt", "db_id": "Q9QYH7" }, { "db_name": "UniProt", "db_id": "Q9UBU3" } ] }, { "id": "DS.d654.s1.e1", "type": "compound", "text": [ "cAMP" ], "offsets": [ [ 231, 235 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6076" } ] } ]
[]
[]
[ { "id": "DS.d654.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d654.s0.e1", "arg2_id": "DS.d654.s0.e0", "normalized": [] }, { "id": "DS.d654.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d654.s1.e1", "arg2_id": "DS.d654.s1.e0", "normalized": [] } ]
DS.d655
18667302
[ { "id": "DS.d655.s0", "type": "", "text": [ "The results indicated that the backbone of POP was composed of (1-->6)-linked-alpha-D-galactopyranosyl and (1-->2,6)-linked-alpha-D-galactopyranosyl residues, which were terminated with a single terminal (1-->)-beta-D-glucose residue at the O-2 position of galactosyl along the main chain in the ratio of 1:1:1." ], "offsets": [ [ 0, 320 ] ] }, { "id": "DS.d655.s1", "type": "", "text": [ "Preliminary tests in vitro showed POP is capable of enhancing concanavalin A (ConA)-or lipopolysaccharide (LPS)-induced lymphocyte proliferation, which suggested that POP could be a potential immunostimulating agent for use in functional foods or medicine against both pathogens and cancer." ], "offsets": [ [ 321, 611 ] ] } ]
[ { "id": "DS.d655.s0.e0", "type": "protein", "text": [ "POP" ], "offsets": [ [ 43, 46 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q9XF19" } ] }, { "id": "DS.d655.s0.e1", "type": "compound", "text": [ "D-galactopyranosyl" ], "offsets": [ [ 87, 105 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "439271" } ] }, { "id": "DS.d655.s0.e2", "type": "compound", "text": [ "D-galactopyranosyl" ], "offsets": [ [ 136, 154 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "439271" } ] }, { "id": "DS.d655.s0.e3", "type": "compound", "text": [ "beta-D-glucose" ], "offsets": [ [ 220, 234 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "206" }, { "db_name": "PubChem", "db_id": "64689" } ] }, { "id": "DS.d655.s1.e0", "type": "protein", "text": [ "POP" ], "offsets": [ [ 355, 358 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q9XF19" } ] }, { "id": "DS.d655.s1.e1", "type": "protein", "text": [ "concanavalin A" ], "offsets": [ [ 383, 397 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P81460" }, { "db_name": "UniProt", "db_id": "P81461" } ] }, { "id": "DS.d655.s1.e2", "type": "protein", "text": [ "ConA" ], "offsets": [ [ 399, 403 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P02866" }, { "db_name": "UniProt", "db_id": "P14894" }, { "db_name": "UniProt", "db_id": "P81460" }, { "db_name": "UniProt", "db_id": "P81461" } ] }, { "id": "DS.d655.s1.e3", "type": "compound", "text": [ "lipopolysaccharide" ], "offsets": [ [ 408, 426 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "11970143" } ] }, { "id": "DS.d655.s1.e4", "type": "protein", "text": [ "POP" ], "offsets": [ [ 488, 491 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q9XF19" } ] } ]
[]
[]
[ { "id": "DS.d655.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d655.s0.e3", "arg2_id": "DS.d655.s0.e0", "normalized": [] }, { "id": "DS.d655.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d655.s0.e1", "arg2_id": "DS.d655.s0.e0", "normalized": [] }, { "id": "DS.d655.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d655.s1.e3", "arg2_id": "DS.d655.s1.e0", "normalized": [] } ]
DS.d656
18668138
[ { "id": "DS.d656.s0", "type": "", "text": [ "Inhibition of the phosphatidyl-inositol-3 kinase/Akt pathway by wortmannin and specific abrogation of Akt1 protein using small-interfering RNA revealed a regulatory function of Akt1 in insulin-mediated VEGF biosynthesis in keratinocytes." ], "offsets": [ [ 0, 237 ] ] } ]
[ { "id": "DS.d656.s0.e0", "type": "compound", "text": [ "wortmannin" ], "offsets": [ [ 64, 74 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "312145" } ] }, { "id": "DS.d656.s0.e1", "type": "protein", "text": [ "Akt1" ], "offsets": [ [ 102, 106 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P31750" }, { "db_name": "UniProt", "db_id": "P47196" }, { "db_name": "UniProt", "db_id": "Q8INB9" }, { "db_name": "UniProt", "db_id": "Q98TY9" } ] }, { "id": "DS.d656.s0.e2", "type": "protein", "text": [ "Akt1" ], "offsets": [ [ 177, 181 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P31750" }, { "db_name": "UniProt", "db_id": "P47196" }, { "db_name": "UniProt", "db_id": "Q8INB9" }, { "db_name": "UniProt", "db_id": "Q98TY9" } ] }, { "id": "DS.d656.s0.e3", "type": "protein", "text": [ "insulin" ], "offsets": [ [ 185, 192 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01314" }, { "db_name": "UniProt", "db_id": "P01316" }, { "db_name": "UniProt", "db_id": "P01319" }, { "db_name": "UniProt", "db_id": "P01320" }, { "db_name": "UniProt", "db_id": "P01324" }, { "db_name": "UniProt", "db_id": "P01328" }, { "db_name": "UniProt", "db_id": "P01330" }, { "db_name": "UniProt", "db_id": "P01331" }, { "db_name": "UniProt", "db_id": "P01334" }, { "db_name": "UniProt", "db_id": "P01336" }, { "db_name": "UniProt", "db_id": "P01340" }, { "db_name": "UniProt", "db_id": "P07453" }, { "db_name": "UniProt", "db_id": "P09476" }, { "db_name": "UniProt", "db_id": "P09477" }, { "db_name": "UniProt", "db_id": "P0C236" }, { "db_name": "UniProt", "db_id": "P12703" }, { "db_name": "UniProt", "db_id": "P12704" }, { "db_name": "UniProt", "db_id": "P12708" }, { "db_name": "UniProt", "db_id": "P13190" }, { "db_name": "UniProt", "db_id": "P18109" }, { "db_name": "UniProt", "db_id": "P29335" }, { "db_name": "UniProt", "db_id": "P42633" }, { "db_name": "UniProt", "db_id": "P67968" }, { "db_name": "UniProt", "db_id": "P67969" }, { "db_name": "UniProt", "db_id": "P67971" }, { "db_name": "UniProt", "db_id": "P67973" }, { "db_name": "UniProt", "db_id": "P67974" }, { "db_name": "UniProt", "db_id": "P68243" }, { "db_name": "UniProt", "db_id": "P68245" }, { "db_name": "UniProt", "db_id": "P68987" }, { "db_name": "UniProt", "db_id": "P68988" }, { "db_name": "UniProt", "db_id": "P68989" }, { "db_name": "UniProt", "db_id": "P68990" }, { "db_name": "UniProt", "db_id": "P68991" }, { "db_name": "UniProt", "db_id": "P68992" }, { "db_name": "UniProt", "db_id": "P69046" }, { "db_name": "UniProt", "db_id": "P69047" }, { "db_name": "UniProt", "db_id": "P69048" }, { "db_name": "UniProt", "db_id": "P81423" }, { "db_name": "UniProt", "db_id": "P81881" }, { "db_name": "UniProt", "db_id": "Q9TQY7" } ] }, { "id": "DS.d656.s0.e4", "type": "protein", "text": [ "VEGF" ], "offsets": [ [ 202, 206 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P15691" }, { "db_name": "UniProt", "db_id": "P15692" }, { "db_name": "UniProt", "db_id": "P26617" }, { "db_name": "UniProt", "db_id": "P49151" }, { "db_name": "UniProt", "db_id": "P50412" }, { "db_name": "UniProt", "db_id": "P67964" }, { "db_name": "UniProt", "db_id": "P67965" }, { "db_name": "UniProt", "db_id": "Q99PS1" }, { "db_name": "UniProt", "db_id": "Q9GKR0" }, { "db_name": "UniProt", "db_id": "Q9MYV3" } ] } ]
[]
[]
[]
DS.d657
18668211
[ { "id": "DS.d657.s0", "type": "", "text": [ "Cross-linked hydrogels showed increased resistance to digestion by testicular hyaluronidase and hyaluronidase SD with increasing hyaluronan concentration." ], "offsets": [ [ 0, 154 ] ] } ]
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[]
[]
[ { "id": "DS.d657.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d657.s0.e2", "arg2_id": "DS.d657.s0.e0", "normalized": [] } ]
DS.d658
18668222
[ { "id": "DS.d658.s0", "type": "", "text": [ "Chlorpyrifos (CPF), a commonly used organophosphorus insecticide, induces acetylcholinesterase inhibition and cholinergic toxicity." ], "offsets": [ [ 0, 131 ] ] } ]
[ { "id": "DS.d658.s0.e0", "type": "compound", "text": [ "Chlorpyrifos" ], "offsets": [ [ 0, 12 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2730" } ] }, { "id": "DS.d658.s0.e1", "type": "protein", "text": [ "acetylcholinesterase" ], "offsets": [ [ 74, 94 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q867X2" }, { "db_name": "UniProt", "db_id": "Q867X3" }, { "db_name": "UniProt", "db_id": "Q86GC9" }, { "db_name": "UniProt", "db_id": "Q92081" } ] } ]
[]
[]
[ { "id": "DS.d658.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d658.s0.e0", "arg2_id": "DS.d658.s0.e1", "normalized": [] } ]
DS.d659
18668243
[ { "id": "DS.d659.s0", "type": "", "text": [ "Role of RNase L in apoptosis induced by 1-(3-C-ethynyl-beta-D-ribo-pentofuranosyl)cytosine." ], "offsets": [ [ 0, 91 ] ] } ]
[ { "id": "DS.d659.s0.e0", "type": "protein", "text": [ "RNase L" ], "offsets": [ [ 8, 15 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q05823" }, { "db_name": "UniProt", "db_id": "Q05921" } ] }, { "id": "DS.d659.s0.e1", "type": "compound", "text": [ "1-(3-C-ethynyl-beta-D-ribo-pentofuranosyl)cytosine" ], "offsets": [ [ 40, 90 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "56841052" } ] } ]
[]
[]
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DS.d660
18668351
[ { "id": "DS.d660.s0", "type": "", "text": [ "It was observed that administration of the PKC inhibitor chelerythrine chloride (5 mg/kg) suppressed the activation of three exercise-induced PKC isoforms (PKCalpha, PKCdelta, and PKCepsilon) and attenuated the exercise-mediated reduction of myocardial infarct size during ischemia-reperfusion injury." ], "offsets": [ [ 0, 301 ] ] } ]
[ { "id": "DS.d660.s0.e0", "type": "compound", "text": [ "chelerythrine chloride" ], "offsets": [ [ 57, 79 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2703" } ] }, { "id": "DS.d660.s0.e1", "type": "protein", "text": [ "PKCalpha" ], "offsets": [ [ 156, 164 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P04409" }, { "db_name": "UniProt", "db_id": "P05696" }, { "db_name": "UniProt", "db_id": "P10102" }, { "db_name": "UniProt", "db_id": "P17252" }, { "db_name": "UniProt", "db_id": "P20444" } ] }, { "id": "DS.d660.s0.e2", "type": "protein", "text": [ "PKCdelta" ], "offsets": [ [ 166, 174 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P10829" } ] } ]
[]
[]
[ { "id": "DS.d660.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d660.s0.e0", "arg2_id": "DS.d660.s0.e2", "normalized": [] }, { "id": "DS.d660.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d660.s0.e0", "arg2_id": "DS.d660.s0.e1", "normalized": [] } ]
DS.d661
18668366
[ { "id": "DS.d661.s0", "type": "", "text": [ "Capsaicin is known to have regulatory effects on gastrointestinal functions via the vanilloid receptor (VR1)." ], "offsets": [ [ 0, 109 ] ] } ]
[ { "id": "DS.d661.s0.e0", "type": "compound", "text": [ "Capsaicin" ], "offsets": [ [ 0, 9 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1548943" } ] }, { "id": "DS.d661.s0.e1", "type": "protein", "text": [ "VR1" ], "offsets": [ [ 104, 107 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q8NER1" } ] } ]
[]
[]
[ { "id": "DS.d661.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d661.s0.e0", "arg2_id": "DS.d661.s0.e1", "normalized": [] } ]
DS.d662
18670196
[ { "id": "DS.d662.s0", "type": "", "text": [ "Cholesteryl ester transfer protein (CETP) is a plasma glycoprotein that facilitates the transfer of neutral lipids and phospholipids between lipoproteins and contributes to the regulation of the plasma concentration of high density lipoprotein cholesterol (HDL-C)." ], "offsets": [ [ 0, 264 ] ] } ]
[ { "id": "DS.d662.s0.e0", "type": "protein", "text": [ "Cholesteryl ester transfer protein" ], "offsets": [ [ 0, 34 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P25914" } ] }, { "id": "DS.d662.s0.e1", "type": "protein", "text": [ "CETP" ], "offsets": [ [ 36, 40 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P11597" }, { "db_name": "UniProt", "db_id": "P22687" }, { "db_name": "UniProt", "db_id": "P25914" }, { "db_name": "UniProt", "db_id": "P47896" } ] }, { "id": "DS.d662.s0.e2", "type": "protein", "text": [ "glycoprotein" ], "offsets": [ [ 54, 66 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P08163" } ] }, { "id": "DS.d662.s0.e3", "type": "protein", "text": [ "high density lipoprotein" ], "offsets": [ [ 219, 243 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P81182" } ] }, { "id": "DS.d662.s0.e4", "type": "compound", "text": [ "cholesterol" ], "offsets": [ [ 244, 255 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "304" }, { "db_name": "PubChem", "db_id": "5997" }, { "db_name": "PubChem", "db_id": "6432564" }, { "db_name": "PubChem", "db_id": "11025495" } ] } ]
[]
[]
[ { "id": "DS.d662.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d662.s0.e4", "arg2_id": "DS.d662.s0.e1", "normalized": [] }, { "id": "DS.d662.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d662.s0.e4", "arg2_id": "DS.d662.s0.e3", "normalized": [] }, { "id": "DS.d662.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d662.s0.e4", "arg2_id": "DS.d662.s0.e2", "normalized": [] }, { "id": "DS.d662.s0.i3", "type": "compound-protein-interaction", "arg1_id": "DS.d662.s0.e4", "arg2_id": "DS.d662.s0.e0", "normalized": [] } ]
DS.d663
18670732
[ { "id": "DS.d663.s0", "type": "", "text": [ "These studies frequently showed that erythropoietic stimulating agents (ESA) with oral or IV iron often resulted in improvement in left ventricular systolic and diastolic function, dilation, and hypertrophy, stabilization or improvement in renal function, reduced hospitalizations, diuretic dose, mitral regurgitation, pulmonary artery pressure, plasma volume, heart rate, serum brain natriuretic peptide levels, and the inflammatory markers C reactive protein and Interleukin 6, and an improvement in New York Heart Association class, exercise capacity, oxygen utilization during exercise, sleep apnea, caloric intake, depression, and quality of life." ], "offsets": [ [ 0, 652 ] ] } ]
[ { "id": "DS.d663.s0.e0", "type": "protein", "text": [ "brain natriuretic peptide" ], "offsets": [ [ 379, 404 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P40753" } ] }, { "id": "DS.d663.s0.e1", "type": "protein", "text": [ "Interleukin 6" ], "offsets": [ [ 465, 478 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P41693" } ] }, { "id": "DS.d663.s0.e2", "type": "compound", "text": [ "oxygen" ], "offsets": [ [ 555, 561 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "977" } ] } ]
[]
[]
[]
DS.d664
18670809
[ { "id": "DS.d664.s0", "type": "", "text": [ "DNA sequences of a calmodulin (CaM)-encoding gene region containing three exons, two introns and a 411-bp mt intergenic spacer (IGS) spanning the cytochrome b (cytb) and NADH 2 genes, were obtained from 49 Acropora species." ], "offsets": [ [ 0, 223 ] ] } ]
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{ "db_name": "UniProt", "db_id": "Q9MGL5" }, { "db_name": "UniProt", "db_id": "Q9MGM4" }, { "db_name": "UniProt", "db_id": "Q9MIX8" } ] }, { "id": "DS.d664.s0.e4", "type": "compound", "text": [ "NADH" ], "offsets": [ [ 170, 174 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "439153" } ] } ]
[]
[]
[]
DS.d665
18670810
[ { "id": "DS.d665.s0", "type": "", "text": [ "Both expression of tac and tac2 were induced by 2% sucrose." ], "offsets": [ [ 0, 59 ] ] } ]
[ { "id": "DS.d665.s0.e0", "type": "protein", "text": [ "tac2" ], "offsets": [ [ 27, 31 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P06767" }, { "db_name": "UniProt", "db_id": "P08435" }, { "db_name": "UniProt", "db_id": "P41539" }, { "db_name": "UniProt", "db_id": "P55099" } ] }, { "id": "DS.d665.s0.e1", "type": "compound", "text": [ "sucrose" ], "offsets": [ [ 51, 58 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5988" } ] } ]
[]
[]
[ { "id": "DS.d665.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d665.s0.e1", "arg2_id": "DS.d665.s0.e0", "normalized": [] } ]
DS.d666
18670880
[ { "id": "DS.d666.s0", "type": "", "text": [ "Contaminants of current high use in the LRGV, such as atrazine, and some of the highly persistent organochlorines, such as toxaphene and DDE, could be potentially associated with modulation of aromatase activity in avian tissues." ], "offsets": [ [ 0, 229 ] ] } ]
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[]
[]
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DS.d667
18670892
[ { "id": "DS.d667.s0", "type": "", "text": [ "In this view, this study aimed at the investigating the use of a crude peroxidase preparation from onion solid by-products for oxidising caffeic acid, a widespread o-diphenol, whose various derivatives may occur in food industry wastes, such as olive mill waste waters." ], "offsets": [ [ 0, 269 ] ] } ]
[ { "id": "DS.d667.s0.e0", "type": "protein", "text": [ "peroxidase" ], "offsets": [ [ 71, 81 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P15984" }, { "db_name": "UniProt", "db_id": "P16147" }, { "db_name": "UniProt", "db_id": "P84714" } ] }, { "id": "DS.d667.s0.e1", "type": "compound", "text": [ "caffeic acid" ], "offsets": [ [ 137, 149 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "689043" } ] } ]
[]
[]
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DS.d668
18670896
[ { "id": "DS.d668.s0", "type": "", "text": [ "Ziram exposures that caused a loss of binding function were examined for effects on expression of key NK cell-surface proteins needed for binding to targets." ], "offsets": [ [ 0, 157 ] ] } ]
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"Q9QSQ7" }, { "db_name": "UniProt", "db_id": "Q9TTC0" }, { "db_name": "UniProt", "db_id": "Q9UKH3" }, { "db_name": "UniProt", "db_id": "Q9UQF0" }, { "db_name": "UniProt", "db_id": "Q9WC60" }, { "db_name": "UniProt", "db_id": "Q9WC69" } ] } ]
[]
[]
[]
DS.d669
18670905
[ { "id": "DS.d669.s0", "type": "", "text": [ "Here, we have investigated how the post-synthetic acetylation of HMGB1 affects its interaction with negatively supercoiled DNA by employing monoacetylated at Lys2 protein, isolated from butyrate-treated cells." ], "offsets": [ [ 0, 209 ] ] } ]
[ { "id": "DS.d669.s0.e0", "type": "protein", "text": [ "HMGB1" ], "offsets": [ [ 65, 70 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P07156" }, { "db_name": "UniProt", "db_id": "P09429" }, { "db_name": "UniProt", "db_id": "P10103" }, { "db_name": "UniProt", "db_id": "P12682" }, { "db_name": "UniProt", "db_id": "P36194" }, { "db_name": "UniProt", "db_id": "Q4R844" }, { "db_name": "UniProt", "db_id": "Q6YKA4" } ] }, { "id": "DS.d669.s0.e1", "type": "compound", "text": [ "butyrate" ], "offsets": [ [ 186, 194 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "264" } ] } ]
[]
[]
[]
DS.d670
18670906
[ { "id": "DS.d670.s0", "type": "", "text": [ "KAP8.1 protein contains high glycine and tyrosine, which concerns regulation and function of the matrix structure fiber." ], "offsets": [ [ 0, 120 ] ] } ]
[ { "id": "DS.d670.s0.e0", "type": "protein", "text": [ "KAP8.1" ], "offsets": [ [ 0, 6 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q8IUC2" } ] }, { "id": "DS.d670.s0.e1", "type": "compound", "text": [ "glycine" ], "offsets": [ [ 29, 36 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "750" } ] }, { "id": "DS.d670.s0.e2", "type": "compound", "text": [ "tyrosine" ], "offsets": [ [ 41, 49 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1153" }, { "db_name": "PubChem", "db_id": "6057" }, { "db_name": "PubChem", "db_id": "5460803" } ] } ]
[]
[]
[ { "id": "DS.d670.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d670.s0.e2", "arg2_id": "DS.d670.s0.e0", "normalized": [] }, { "id": "DS.d670.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d670.s0.e1", "arg2_id": "DS.d670.s0.e0", "normalized": [] } ]
DS.d671
18671273
[ { "id": "DS.d671.s0", "type": "", "text": [ "Cycloheximide inhibited MIH induced Mos expression and its phosphorylation, which in turn reduced Myt1 phosphorylation and GVBD." ], "offsets": [ [ 0, 128 ] ] } ]
[ { "id": "DS.d671.s0.e0", "type": "compound", "text": [ "Cycloheximide" ], "offsets": [ [ 0, 13 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6197" } ] }, { "id": "DS.d671.s0.e1", "type": "protein", "text": [ "MIH" ], "offsets": [ [ 24, 27 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O61389" }, { "db_name": "UniProt", "db_id": "O96605" }, { "db_name": "UniProt", "db_id": "P19806" }, { "db_name": "UniProt", "db_id": "P55321" }, { "db_name": "UniProt", "db_id": "P55846" }, { "db_name": "UniProt", "db_id": "P55847" }, { "db_name": "UniProt", "db_id": "P55848" }, { "db_name": "UniProt", "db_id": "P83220" }, { "db_name": "UniProt", "db_id": "P83636" }, { "db_name": "UniProt", "db_id": "Q10987" }, { "db_name": "UniProt", "db_id": "Q27225" } ] }, { "id": "DS.d671.s0.e2", "type": "protein", "text": [ "Mos" ], "offsets": [ [ 36, 39 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P00536" }, { "db_name": "UniProt", "db_id": "P00539" }, { "db_name": "UniProt", "db_id": "P12965" } ] }, { "id": "DS.d671.s0.e3", "type": "protein", "text": [ "Myt1" ], "offsets": [ [ 98, 102 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P70047" }, { "db_name": "UniProt", "db_id": "Q8CFC2" }, { "db_name": "UniProt", "db_id": "Q91618" }, { "db_name": "UniProt", "db_id": "Q9ESG9" }, { "db_name": "UniProt", "db_id": "Q9NI63" } ] } ]
[]
[]
[ { "id": "DS.d671.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d671.s0.e0", "arg2_id": "DS.d671.s0.e3", "normalized": [] }, { "id": "DS.d671.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d671.s0.e0", "arg2_id": "DS.d671.s0.e2", "normalized": [] }, { "id": "DS.d671.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d671.s0.e0", "arg2_id": "DS.d671.s0.e1", "normalized": [] } ]
DS.d672
18671672
[ { "id": "DS.d672.s0", "type": "", "text": [ "CLNO2 levels were found to increase approximately 20-fold 24 h after macrophage activation with Escherichia coli lipopolysaccharide plus interferon-gamma ; this response was concurrent with an increase in the expression of NOS2 (inducible nitric oxide synthase) and was inhibited by the (*)NO (nitric oxide) inhibitor L-NAME (N(G)-nitro-L-arginine methyl ester)." ], "offsets": [ [ 0, 362 ] ] } ]
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[]
[]
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DS.d673
18671761
[ { "id": "DS.d673.s0", "type": "", "text": [ "Parkin-mediated ubiquitination regulates phospholipase C-gamma1." ], "offsets": [ [ 0, 64 ] ] } ]
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[]
[]
[ { "id": "DS.d673.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d673.s0.e0", "arg2_id": "DS.d673.s0.e1", "normalized": [] } ]
DS.d674
18671795
[ { "id": "DS.d674.s0", "type": "", "text": [ "Short-acting insulin analogues, in comparison with regular human insulin (HRI), provide a greater control of postprandial glucose, while their superiority on haemoglobin A1c (HbA1c) is controversial." ], "offsets": [ [ 0, 199 ] ] } ]
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[]
[]
[ { "id": "DS.d674.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d674.s0.e3", "arg2_id": "DS.d674.s0.e0", "normalized": [] }, { "id": "DS.d674.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d674.s0.e3", "arg2_id": "DS.d674.s0.e2", "normalized": [] } ]
DS.d675
18671897
[ { "id": "DS.d675.s0", "type": "", "text": [ "Western blotting showed that carbenoxolone down-regulated Cx43 protein expression in the BA, which in the SAH-only group was significantly higher than that of the normal group." ], "offsets": [ [ 0, 176 ] ] } ]
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[]
[]
[ { "id": "DS.d675.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d675.s0.e0", "arg2_id": "DS.d675.s0.e1", "normalized": [] } ]
DS.d676
18672341
[ { "id": "DS.d676.s0", "type": "", "text": [ "Hepatocytes exposed to resistin, but only in the presence of insulin, show a decrease in insulin-stimulated glycogen content." ], "offsets": [ [ 0, 125 ] ] } ]
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[]
[]
[ { "id": "DS.d676.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d676.s0.e2", "arg2_id": "DS.d676.s0.e0", "normalized": [] } ]
DS.d678
18673089
[ { "id": "DS.d678.s0", "type": "", "text": [ "Differentiated EBD cells in both monolayer and three-dimensional in vitro culture demonstrated fat granules by light microscopy, stained positive for lipids with oil red-O, and expressed adipocyte-specific genes (lipoprotein lipase (LPL), peroxisome proliferator activated receptor gamma2, and adipocyte-specific fatty acid binding protein (alphaP2))." ], "offsets": [ [ 0, 351 ] ] } ]
[ { "id": "DS.d678.s0.e0", "type": "compound", "text": [ "oil red-O" ], "offsets": [ [ 162, 171 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6046885" }, { "db_name": "PubChem", "db_id": "6821284" } ] }, { "id": "DS.d678.s0.e1", "type": "protein", "text": [ "lipase" ], "offsets": [ [ 225, 231 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q7M4U7" } ] }, { "id": "DS.d678.s0.e2", "type": "protein", "text": [ "LPL" ], "offsets": [ [ 233, 236 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O46647" }, { "db_name": "UniProt", "db_id": "P06858" }, { "db_name": "UniProt", "db_id": "P11151" }, { "db_name": "UniProt", "db_id": "P11152" }, { "db_name": "UniProt", "db_id": "P11153" }, { "db_name": "UniProt", "db_id": "P11602" }, { "db_name": "UniProt", "db_id": "P49060" }, { "db_name": "UniProt", "db_id": "P49923" }, { "db_name": "UniProt", "db_id": "P55031" }, { "db_name": "UniProt", "db_id": "Q06000" }, { "db_name": "UniProt", "db_id": "Q29524" } ] }, { "id": "DS.d678.s0.e3", "type": "protein", "text": [ "gamma2" ], "offsets": [ [ 282, 288 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P02528" } ] }, { "id": "DS.d678.s0.e4", "type": "protein", "text": [ "fatty acid binding protein" ], "offsets": [ [ 313, 339 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O42494" }, { "db_name": "UniProt", "db_id": "O45035" }, { "db_name": "UniProt", "db_id": "O76821" }, { "db_name": "UniProt", "db_id": "P80547" }, { "db_name": "UniProt", "db_id": "Q17284" }, { "db_name": "UniProt", "db_id": "Q8MUC1" }, { "db_name": "UniProt", "db_id": "Q9U5P1" } ] } ]
[]
[]
[]
DS.d679
18673303
[ { "id": "DS.d679.s0", "type": "", "text": [ "In addition, AIT induced a more favourable regulation of blood glucose and insulin compared with MTG." ], "offsets": [ [ 0, 101 ] ] } ]
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[]
[]
[]
DS.d680
18673333
[ { "id": "DS.d680.s0", "type": "", "text": [ "Beta1,4-galactosyltransferase-I (B4GALT1), one of seven beta1,4-galactosyltransferases, is an enzyme commonly found in the trans-Golgi complex that adds galactose to oligosaccharides." ], "offsets": [ [ 0, 183 ] ] }, { "id": "DS.d680.s1", "type": "", "text": [ "When compared to the other mammalian B4GALT1 genes, the porcine coding sequence contained a single threonine codon inserted into the region encoding the cytoplasmic domain." ], "offsets": [ [ 184, 356 ] ] } ]
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[]
[]
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DS.d681
18674953
[ { "id": "DS.d681.s0", "type": "", "text": [ "Gyp inhibited the levels of the anti-apoptotic proteins Bcl-2 and Bcl-xl, but promoted the levels of the pro-apoptotic protein Bax." ], "offsets": [ [ 0, 131 ] ] }, { "id": "DS.d681.s1", "type": "", "text": [ "In conclusion, Gyp induced ER stress and production of reactive oxygen species and Ca(2+), change the ratio of Bcl-2 and Bax, followed by the dysfunction of mitochondria, caused cytochrome c release, activation of caspase-3 before leading to apoptosis." ], "offsets": [ [ 132, 384 ] ] } ]
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"db_id": "P81280" }, { "db_name": "UniProt", "db_id": "P81459" }, { "db_name": "UniProt", "db_id": "P99998" }, { "db_name": "UniProt", "db_id": "P99999" }, { "db_name": "UniProt", "db_id": "Q41346" }, { "db_name": "UniProt", "db_id": "Q4HVX7" }, { "db_name": "UniProt", "db_id": "Q52V08" }, { "db_name": "UniProt", "db_id": "Q52V09" }, { "db_name": "UniProt", "db_id": "Q52V10" }, { "db_name": "UniProt", "db_id": "Q5RFH4" }, { "db_name": "UniProt", "db_id": "Q640U4" }, { "db_name": "UniProt", "db_id": "Q6C9Q0" }, { "db_name": "UniProt", "db_id": "Q6IQM2" }, { "db_name": "UniProt", "db_id": "Q6Q4H8" }, { "db_name": "UniProt", "db_id": "Q6QLW4" }, { "db_name": "UniProt", "db_id": "Q6WUX8" }, { "db_name": "UniProt", "db_id": "Q753F4" }, { "db_name": "UniProt", "db_id": "Q7YR71" }, { "db_name": "UniProt", "db_id": "Q96VP3" } ] } ]
[]
[]
[ { "id": "DS.d681.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d681.s0.e0", "arg2_id": "DS.d681.s0.e1", "normalized": [] }, { "id": "DS.d681.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d681.s0.e0", "arg2_id": "DS.d681.s0.e2", "normalized": [] }, { "id": "DS.d681.s1.i4", "type": "compound-protein-interaction", "arg1_id": "DS.d681.s1.e0", "arg2_id": "DS.d681.s1.e3", "normalized": [] }, { "id": "DS.d681.s1.i6", "type": "compound-protein-interaction", "arg1_id": "DS.d681.s1.e0", "arg2_id": "DS.d681.s1.e5", "normalized": [] }, { "id": "DS.d681.s1.i8", "type": "compound-protein-interaction", "arg1_id": "DS.d681.s1.e0", "arg2_id": "DS.d681.s1.e4", "normalized": [] } ]
DS.d682
18675966
[ { "id": "DS.d682.s0", "type": "", "text": [ "To compare expression of endometrial estrogen (ER) and progesterone (PR) receptors, beta(3)-integrin subunit, leukemia inhibitory factor (LIF), interleukin-6 (IL-6), and pinopodes in Indian women using ormeloxifene as a contraceptive with fertile and infertile subjects during the window of implantation." ], "offsets": [ [ 0, 304 ] ] } ]
[ { "id": "DS.d682.s0.e0", "type": "protein", "text": [ "LIF" ], "offsets": [ [ 138, 141 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O62728" }, { "db_name": "UniProt", "db_id": "P09056" }, { "db_name": "UniProt", "db_id": "P15018" }, { "db_name": "UniProt", "db_id": "P17777" }, { "db_name": "UniProt", "db_id": "Q27956" } ] }, { "id": "DS.d682.s0.e1", "type": "protein", "text": [ "interleukin-6" ], "offsets": [ [ 144, 157 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P41693" } ] }, { "id": "DS.d682.s0.e2", "type": "protein", "text": [ "IL-6" ], "offsets": [ [ 159, 163 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O35736" }, { "db_name": "UniProt", "db_id": "P05231" }, { "db_name": "UniProt", "db_id": "P08505" }, { "db_name": "UniProt", "db_id": "P20607" }, { "db_name": "UniProt", "db_id": "P26892" }, { "db_name": "UniProt", "db_id": "P26893" }, { "db_name": "UniProt", "db_id": "P29455" }, { "db_name": "UniProt", "db_id": "P41323" }, { "db_name": "UniProt", "db_id": "P41683" }, { "db_name": "UniProt", "db_id": "P41693" }, { "db_name": "UniProt", "db_id": "P46650" }, { "db_name": "UniProt", "db_id": "P51494" }, { "db_name": "UniProt", "db_id": "P79341" }, { "db_name": "UniProt", "db_id": "Q25BC2" }, { "db_name": "UniProt", "db_id": "Q28319" }, { "db_name": "UniProt", "db_id": "Q28747" }, { "db_name": "UniProt", "db_id": "Q28819" }, { "db_name": "UniProt", "db_id": "Q2MH06" }, { "db_name": "UniProt", "db_id": "Q5I6E3" }, { "db_name": "UniProt", "db_id": "Q6V919" }, { "db_name": "UniProt", "db_id": "Q865W7" }, { "db_name": "UniProt", "db_id": "Q865X6" }, { "db_name": "UniProt", "db_id": "Q8MKH0" }, { "db_name": "UniProt", "db_id": "Q95181" }, { "db_name": "UniProt", "db_id": "Q9MZR1" }, { "db_name": "UniProt", "db_id": "Q9XT80" } ] }, { "id": "DS.d682.s0.e3", "type": "compound", "text": [ "ormeloxifene" ], "offsets": [ [ 202, 214 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "35805" }, { "db_name": "PubChem", "db_id": "154413" } ] } ]
[]
[]
[ { "id": "DS.d682.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d682.s0.e3", "arg2_id": "DS.d682.s0.e2", "normalized": [] }, { "id": "DS.d682.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d682.s0.e3", "arg2_id": "DS.d682.s0.e1", "normalized": [] }, { "id": "DS.d682.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d682.s0.e3", "arg2_id": "DS.d682.s0.e0", "normalized": [] } ]
DS.d683
18676014
[ { "id": "DS.d683.s0", "type": "", "text": [ "We have also observed that the reduction of transition at 95+/-3 degrees C in thermal scans of nuclear preparations isolated from blood of B-CLL randomized patients who showed response to cladribine or fludarabine combined with cyclophosphamide, i.e., CC and FC, respectively, corresponded with the decrease or disappearance of anti-apoptotic proteins Bcl-2 and/or Mcl 1." ], "offsets": [ [ 0, 371 ] ] } ]
[ { "id": "DS.d683.s0.e0", "type": "compound", "text": [ "cladribine" ], "offsets": [ [ 188, 198 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "20279" } ] }, { "id": "DS.d683.s0.e1", "type": "compound", "text": [ "fludarabine" ], "offsets": [ [ 202, 213 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "657237" } ] }, { "id": "DS.d683.s0.e2", "type": "compound", "text": [ "cyclophosphamide" ], "offsets": [ [ 228, 244 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2907" }, { "db_name": "PubChem", "db_id": "9554282" } ] }, { "id": "DS.d683.s0.e3", "type": "protein", "text": [ "Bcl-2" ], "offsets": [ [ 352, 357 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P10417" }, { "db_name": "UniProt", "db_id": "P49950" } ] }, { "id": "DS.d683.s0.e4", "type": "protein", "text": [ "Mcl" ], "offsets": [ [ 365, 368 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q69FH1" }, { "db_name": "UniProt", "db_id": "Q9Z2H6" } ] } ]
[]
[]
[]
DS.d684
18676199
[ { "id": "DS.d684.s0", "type": "", "text": [ "Exposure of erythrocytes to PGNs increased cytosolic Ca(2+) concentration, increased ceramide formation, enhanced the percentage of annexin V-binding erythrocytes, decreased erythrocyte forward scatter, and lowered the intracellular ATP concentration." ], "offsets": [ [ 0, 251 ] ] } ]
[ { "id": "DS.d684.s0.e0", "type": "protein", "text": [ "PGNs" ], "offsets": [ [ 28, 32 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q9UQ90" } ] }, { "id": "DS.d684.s0.e1", "type": "compound", "text": [ "Ca(2" ], "offsets": [ [ 53, 57 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "271" } ] }, { "id": "DS.d684.s0.e2", "type": "protein", "text": [ "annexin V" ], "offsets": [ [ 132, 141 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P08758" }, { "db_name": "UniProt", "db_id": "P14668" }, { "db_name": "UniProt", "db_id": "P17153" }, { "db_name": "UniProt", "db_id": "P48036" }, { "db_name": "UniProt", "db_id": "P70075" }, { "db_name": "UniProt", "db_id": "P81287" }, { "db_name": "UniProt", "db_id": "Q4R4H7" }, { "db_name": "UniProt", "db_id": "Q5R1W0" } ] }, { "id": "DS.d684.s0.e3", "type": "compound", "text": [ "ATP" ], "offsets": [ [ 233, 236 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5957" } ] } ]
[]
[]
[ { "id": "DS.d684.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d684.s0.e3", "arg2_id": "DS.d684.s0.e0", "normalized": [] }, { "id": "DS.d684.s0.i3", "type": "compound-protein-interaction", "arg1_id": "DS.d684.s0.e1", "arg2_id": "DS.d684.s0.e0", "normalized": [] } ]
DS.d685
18676776
[ { "id": "DS.d685.s0", "type": "", "text": [ "Inhibition of mitogen-activated protein kinase (MAPK) and Akt prevented the antiapoptotic effects of nicotine and decreased chemotherapy-induced apoptosis." ], "offsets": [ [ 0, 155 ] ] }, { "id": "DS.d685.s1", "type": "", "text": [ "Nicotine up-regulated Akt-mediated antiapoptotic X-linked inhibitor of apoptosis protein and phosphorylated proapoptotic Bcl2-antagonist of cell death." ], "offsets": [ [ 156, 307 ] ] } ]
[ { "id": "DS.d685.s0.e0", "type": "protein", "text": [ "mitogen-activated protein kinase" ], "offsets": [ [ 14, 46 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q00859" } ] }, { "id": "DS.d685.s0.e1", "type": "protein", "text": [ "MAPK" ], "offsets": [ [ 48, 52 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O42781" }, { "db_name": "UniProt", "db_id": "P27638" }, { "db_name": "UniProt", "db_id": "Q00859" } ] }, { "id": "DS.d685.s0.e2", "type": "protein", "text": [ "Akt" ], "offsets": [ [ 58, 61 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P31750" }, { "db_name": "UniProt", "db_id": "Q8INB9" } ] }, { "id": "DS.d685.s0.e3", "type": "compound", "text": [ "nicotine" ], "offsets": [ [ 101, 109 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "942" }, { "db_name": "PubChem", "db_id": "89594" }, { "db_name": "PubChem", "db_id": "157672" } ] }, { "id": "DS.d685.s1.e0", "type": "compound", "text": [ "Nicotine" ], "offsets": [ [ 156, 164 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "942" }, { "db_name": "PubChem", "db_id": "89594" }, { "db_name": "PubChem", "db_id": "157672" } ] }, { "id": "DS.d685.s1.e3", "type": "protein", "text": [ "Bcl2-antagonist of cell death" ], "offsets": [ [ 277, 306 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O35147" }, { "db_name": "UniProt", "db_id": "Q61337" }, { "db_name": "UniProt", "db_id": "Q92934" } ] } ]
[]
[]
[ { "id": "DS.d685.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d685.s0.e3", "arg2_id": "DS.d685.s0.e2", "normalized": [] }, { "id": "DS.d685.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d685.s0.e3", "arg2_id": "DS.d685.s0.e1", "normalized": [] }, { "id": "DS.d685.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d685.s0.e3", "arg2_id": "DS.d685.s0.e0", "normalized": [] }, { "id": "DS.d685.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d685.s1.e0", "arg2_id": "DS.d685.s1.e3", "normalized": [] } ]
DS.d686
18677478
[ { "id": "DS.d686.s0", "type": "", "text": [ "Induction of NY-ESO-1 expression on tumor targets using the demethylating agent 5-aza-2'-deoxycytidine (alone or in combination with the histone deacetylase inhibitor depsipeptide) resulted in enhanced interferon-gamma secretion by the TCR-transduced PBL on culture with treated targets." ], "offsets": [ [ 0, 287 ] ] } ]
[ { "id": "DS.d686.s0.e0", "type": "compound", "text": [ "5-aza-2'-deoxycytidine" ], "offsets": [ [ 80, 102 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "451668" } ] }, { "id": "DS.d686.s0.e1", "type": "compound", "text": [ "depsipeptide" ], "offsets": [ [ 167, 179 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5352062" } ] }, { "id": "DS.d686.s0.e2", "type": "protein", "text": [ "interferon-gamma" ], "offsets": [ [ 202, 218 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q9TTB0" } ] } ]
[]
[]
[ { "id": "DS.d686.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d686.s0.e1", "arg2_id": "DS.d686.s0.e2", "normalized": [] }, { "id": "DS.d686.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d686.s0.e0", "arg2_id": "DS.d686.s0.e2", "normalized": [] } ]
DS.d687
18677521
[ { "id": "DS.d687.s0", "type": "", "text": [ "In the absence of OmcB, cells lost the ability to reduce soluble or insoluble Fe(III)." ], "offsets": [ [ 0, 86 ] ] }, { "id": "DS.d687.s1", "type": "", "text": [ "DNA sequences of upstream regions of coregulated operons in the adapted mutant are divergent, suggesting the presence of recognition sites for different transcriptional regulators and indicating that adaptation of the omcB mutant to growth on soluble Fe(III) has shifted the relevant expression networks involved to a more diverse molecular basis." ], "offsets": [ [ 87, 434 ] ] } ]
[ { "id": "DS.d687.s0.e0", "type": "protein", "text": [ "OmcB" ], "offsets": [ [ 18, 22 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P18151" }, { "db_name": "UniProt", "db_id": "P21354" }, { "db_name": "UniProt", "db_id": "P23603" }, { "db_name": "UniProt", "db_id": "P23700" }, { "db_name": "UniProt", "db_id": "P23701" }, { "db_name": "UniProt", "db_id": "P26758" }, { "db_name": "UniProt", "db_id": "P94664" }, { "db_name": "UniProt", "db_id": "Q253E5" }, { "db_name": "UniProt", "db_id": "Q3KLQ7" }, { "db_name": "UniProt", "db_id": "Q548P6" }, { "db_name": "UniProt", "db_id": "Q933I7" }, { "db_name": "UniProt", "db_id": "Q9AIS7" }, { "db_name": "UniProt", "db_id": "Q9PJV0" } ] }, { "id": "DS.d687.s0.e1", "type": "compound", "text": [ "Fe(III" ], "offsets": [ [ 78, 84 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "29936" } ] }, { "id": "DS.d687.s1.e0", "type": "protein", "text": [ "transcriptional regulators" ], "offsets": [ [ 240, 266 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q9CJ45" } ] }, { "id": "DS.d687.s1.e1", "type": "compound", "text": [ "Fe(III" ], "offsets": [ [ 338, 344 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "29936" } ] } ]
[]
[]
[ { "id": "DS.d687.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d687.s0.e1", "arg2_id": "DS.d687.s0.e0", "normalized": [] } ]
DS.d688
18677561
[ { "id": "DS.d688.s0", "type": "", "text": [ "Elevated beta1,4-galactosyltransferase-I induced by the intraspinal injection of lipopolysaccharide." ], "offsets": [ [ 0, 100 ] ] }, { "id": "DS.d688.s1", "type": "", "text": [ "E-selectin, which ligand was modified by beta1,4-GalT-I, was correlated with galactose-containing glycans following injecting LPS into spinal cord." ], "offsets": [ [ 101, 248 ] ] } ]
[ { "id": "DS.d688.s0.e0", "type": "protein", "text": [ "galactosyltransferase" ], "offsets": [ [ 17, 38 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P14769" }, { "db_name": "UniProt", "db_id": "P23336" }, { "db_name": "UniProt", "db_id": "P50127" } ] }, { "id": "DS.d688.s0.e1", "type": "compound", "text": [ "lipopolysaccharide" ], "offsets": [ [ 81, 99 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "11970143" } ] }, { "id": "DS.d688.s1.e0", "type": "protein", "text": [ "GalT" ], "offsets": [ [ 150, 154 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O33836" }, { "db_name": "UniProt", "db_id": "O84904" }, { "db_name": "UniProt", "db_id": "P09148" }, { "db_name": "UniProt", "db_id": "P13212" }, { "db_name": "UniProt", "db_id": "P22714" }, { "db_name": "UniProt", "db_id": "P31764" }, { "db_name": "UniProt", "db_id": "P39575" }, { "db_name": "UniProt", "db_id": "P45981" }, { "db_name": "UniProt", "db_id": "P96994" }, { "db_name": "UniProt", "db_id": "Q00054" }, { "db_name": "UniProt", "db_id": "Q5LYY8" }, { "db_name": "UniProt", "db_id": "Q5M3K1" }, { "db_name": "UniProt", "db_id": "Q836N8" }, { "db_name": "UniProt", "db_id": "Q88SF0" }, { "db_name": "UniProt", "db_id": "Q8R8R6" }, { "db_name": "UniProt", "db_id": "Q8RHC9" }, { "db_name": "UniProt", "db_id": "Q8VS92" }, { "db_name": "UniProt", "db_id": "Q8XKP8" }, { "db_name": "UniProt", "db_id": "Q93MM1" }, { "db_name": "UniProt", "db_id": "Q97EZ4" }, { "db_name": "UniProt", "db_id": "Q9CE63" }, { "db_name": "UniProt", "db_id": "Q9KDV2" }, { "db_name": "UniProt", "db_id": "Q9RGR9" }, { "db_name": "UniProt", "db_id": "Q9S6S3" }, { "db_name": "UniProt", "db_id": "Q9ZB09" } ] }, { "id": "DS.d688.s1.e1", "type": "compound", "text": [ "galactose" ], "offsets": [ [ 178, 187 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6036" }, { "db_name": "PubChem", "db_id": "439353" }, { "db_name": "PubChem", "db_id": "439357" } ] } ]
[]
[]
[ { "id": "DS.d688.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d688.s0.e1", "arg2_id": "DS.d688.s0.e0", "normalized": [] } ]
DS.d689
18677571
[ { "id": "DS.d689.s0", "type": "", "text": [ "Effects of P85 on amino acid transporters were examined using their substrates: (3)H-phenylalanine, (3)H-lysine, and (3)H-methylaminoisobutyric acid, respectively." ], "offsets": [ [ 0, 163 ] ] } ]
[ { "id": "DS.d689.s0.e0", "type": "protein", "text": [ "P85" ], "offsets": [ [ 11, 14 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O43439" }, { "db_name": "UniProt", "db_id": "P46655" }, { "db_name": "UniProt", "db_id": "P49846" }, { "db_name": "UniProt", "db_id": "Q14155" } ] }, { "id": "DS.d689.s0.e1", "type": "compound", "text": [ "phenylalanine" ], "offsets": [ [ 85, 98 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "994" }, { "db_name": "PubChem", "db_id": "6140" }, { "db_name": "PubChem", "db_id": "71567" } ] }, { "id": "DS.d689.s0.e2", "type": "compound", "text": [ "lysine" ], "offsets": [ [ 105, 111 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "866" }, { "db_name": "PubChem", "db_id": "5962" } ] } ]
[]
[]
[]
DS.d690
18677583
[ { "id": "DS.d690.s0", "type": "", "text": [ "Valproate, an anticonvulsant and mood stabilizer, up-regulates Bcl-2, a neurotrophic/neuroprotective protein." ], "offsets": [ [ 0, 109 ] ] }, { "id": "DS.d690.s1", "type": "", "text": [ "In this study, we investigated the molecular mechanism through which Bcl-2 is up-regulated by valproate using cultured human neuron-like cells." ], "offsets": [ [ 110, 253 ] ] }, { "id": "DS.d690.s2", "type": "", "text": [ "Valproate, within therapeutically relevant ranges, induced time- and concentration-dependent up-regulations of both Bcl-2 messenger RNA and protein implicating an underlying gene transcriptional-mediated mechanism." ], "offsets": [ [ 254, 468 ] ] }, { "id": "DS.d690.s3", "type": "", "text": [ "Valproate increased transcriptional activity of a human bcl-2 promoter-reporter gene construct." ], "offsets": [ [ 469, 564 ] ] }, { "id": "DS.d690.s4", "type": "", "text": [ "ERK and/or PI3K pathway inhibitors and RSK1 small hairpin RNA knockdown reduced, but did not abolish, baseline and valproate-induced promoter activities and lowered Bcl-2 protein levels." ], "offsets": [ [ 565, 751 ] ] }, { "id": "DS.d690.s5", "type": "", "text": [ "These data collectively suggest that valproate induces Bcl-2 regulation partially through activations of the ERK and PI3K cascades and their convergent kinase, RSK, although other unknown mechanism(s) are likely involved." ], "offsets": [ [ 752, 973 ] ] }, { "id": "DS.d690.s6", "type": "", "text": [ "Given the known roles of Bcl-2 in the central nervous system, the current findings offer a partial yet complex molecular mechanistic explanation for the known neurobiological effects of valproate including neurite growth, neuronal survival, and neurogenesis." ], "offsets": [ [ 974, 1232 ] ] } ]
[ { "id": "DS.d690.s0.e0", "type": "compound", "text": [ "Valproate" ], "offsets": [ [ 0, 9 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "3121" } ] }, { "id": "DS.d690.s0.e1", "type": "protein", "text": [ "Bcl-2" ], "offsets": [ [ 63, 68 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P10417" }, { "db_name": "UniProt", "db_id": "P49950" } ] }, { "id": "DS.d690.s1.e0", "type": "protein", "text": [ "Bcl-2" ], "offsets": [ [ 179, 184 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P10417" }, { "db_name": "UniProt", "db_id": "P49950" } ] }, { "id": "DS.d690.s1.e1", "type": "compound", "text": [ "valproate" ], "offsets": [ [ 204, 213 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "3121" } ] }, { "id": "DS.d690.s2.e0", "type": "compound", "text": [ "Valproate" ], "offsets": [ [ 254, 263 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "3121" } ] }, { "id": "DS.d690.s2.e1", "type": "protein", "text": [ "Bcl-2" ], "offsets": [ [ 370, 375 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P10417" }, { "db_name": "UniProt", "db_id": "P49950" } ] }, { "id": "DS.d690.s3.e0", "type": "compound", "text": [ "Valproate" ], "offsets": [ [ 469, 478 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "3121" } ] }, { "id": "DS.d690.s3.e1", "type": "protein", "text": [ "bcl-2" ], "offsets": [ [ 525, 530 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P10417" }, { "db_name": "UniProt", "db_id": "P49950" } ] }, { "id": "DS.d690.s4.e0", "type": "compound", "text": [ "valproate" ], "offsets": [ [ 680, 689 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "3121" } ] }, { "id": "DS.d690.s4.e1", "type": "protein", "text": [ "Bcl-2" ], "offsets": [ [ 730, 735 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P10417" }, { "db_name": "UniProt", "db_id": "P49950" } ] }, { "id": "DS.d690.s5.e0", "type": "compound", "text": [ "valproate" ], "offsets": [ [ 789, 798 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "3121" } ] }, { "id": "DS.d690.s5.e1", "type": "protein", "text": [ "Bcl-2" ], "offsets": [ [ 807, 812 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P10417" }, { "db_name": "UniProt", "db_id": "P49950" } ] }, { "id": "DS.d690.s5.e2", "type": "protein", "text": [ "ERK" ], "offsets": [ [ 861, 864 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P29323" } ] }, { "id": "DS.d690.s5.e3", "type": "protein", "text": [ "PI3K" ], "offsets": [ [ 869, 873 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O00329" }, { "db_name": "UniProt", "db_id": "O02697" }, { "db_name": "UniProt", "db_id": "O35904" }, { "db_name": "UniProt", "db_id": "P23727" }, { "db_name": "UniProt", "db_id": "P26450" }, { "db_name": "UniProt", "db_id": "P27986" }, { "db_name": "UniProt", "db_id": "P32871" }, { "db_name": "UniProt", "db_id": "P42336" }, { "db_name": "UniProt", "db_id": "P42337" }, { "db_name": "UniProt", "db_id": "P42338" }, { "db_name": "UniProt", "db_id": "P42347" }, { "db_name": "UniProt", "db_id": "P42348" }, { "db_name": "UniProt", "db_id": "P48736" }, { "db_name": "UniProt", "db_id": "P54673" }, { "db_name": "UniProt", "db_id": "P54674" }, { "db_name": "UniProt", "db_id": "P54675" }, { "db_name": "UniProt", "db_id": "P54676" }, { "db_name": "UniProt", "db_id": "Q63787" }, { "db_name": "UniProt", "db_id": "Q8BTI9" }, { "db_name": "UniProt", "db_id": "Q8UUU2" }, { "db_name": "UniProt", "db_id": "Q9JHG7" }, { "db_name": "UniProt", "db_id": "Q9Z1L0" } ] }, { "id": "DS.d690.s5.e4", "type": "protein", "text": [ "RSK" ], "offsets": [ [ 912, 915 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P18652" } ] }, { "id": "DS.d690.s6.e0", "type": "protein", "text": [ "Bcl-2" ], "offsets": [ [ 999, 1004 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P10417" }, { "db_name": "UniProt", "db_id": "P49950" } ] }, { "id": "DS.d690.s6.e1", "type": "compound", "text": [ "valproate" ], "offsets": [ [ 1160, 1169 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "3121" } ] } ]
[]
[]
[ { "id": "DS.d690.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d690.s0.e0", "arg2_id": "DS.d690.s0.e1", "normalized": [] }, { "id": "DS.d690.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d690.s1.e1", "arg2_id": "DS.d690.s1.e0", "normalized": [] }, { "id": "DS.d690.s2.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d690.s2.e0", "arg2_id": "DS.d690.s2.e1", "normalized": [] }, { "id": "DS.d690.s3.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d690.s3.e0", "arg2_id": "DS.d690.s3.e1", "normalized": [] }, { "id": "DS.d690.s5.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d690.s5.e0", "arg2_id": "DS.d690.s5.e3", "normalized": [] }, { "id": "DS.d690.s5.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d690.s5.e0", "arg2_id": "DS.d690.s5.e4", "normalized": [] }, { "id": "DS.d690.s5.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d690.s5.e0", "arg2_id": "DS.d690.s5.e1", "normalized": [] }, { "id": "DS.d690.s5.i3", "type": "compound-protein-interaction", "arg1_id": "DS.d690.s5.e0", "arg2_id": "DS.d690.s5.e2", "normalized": [] } ]
DS.d691
18679593
[ { "id": "DS.d691.s0", "type": "", "text": [ "With covalent method, glutaraldehyde was introduced to immobilize cellobiase." ], "offsets": [ [ 0, 77 ] ] } ]
[ { "id": "DS.d691.s0.e0", "type": "compound", "text": [ "glutaraldehyde" ], "offsets": [ [ 22, 36 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "3485" } ] }, { "id": "DS.d691.s0.e1", "type": "protein", "text": [ "cellobiase" ], "offsets": [ [ 66, 76 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O33843" }, { "db_name": "UniProt", "db_id": "P06835" }, { "db_name": "UniProt", "db_id": "P07337" }, { "db_name": "UniProt", "db_id": "P10482" }, { "db_name": "UniProt", "db_id": "P12614" }, { "db_name": "UniProt", "db_id": "P14002" }, { "db_name": "UniProt", "db_id": "P15885" }, { "db_name": "UniProt", "db_id": "P16084" }, { "db_name": "UniProt", "db_id": "P22073" }, { "db_name": "UniProt", "db_id": "P22505" }, { "db_name": "UniProt", "db_id": "P22506" }, { "db_name": "UniProt", "db_id": "P22507" }, { "db_name": "UniProt", "db_id": "P26208" }, { "db_name": "UniProt", "db_id": "P27034" }, { "db_name": "UniProt", "db_id": "P29090" }, { "db_name": "UniProt", "db_id": "P29091" }, { "db_name": "UniProt", "db_id": "P33363" }, { "db_name": "UniProt", "db_id": "P38645" }, { "db_name": "UniProt", "db_id": "P40740" }, { "db_name": "UniProt", "db_id": "P42403" }, { "db_name": "UniProt", "db_id": "P48825" }, { "db_name": "UniProt", "db_id": "P49235" }, { "db_name": "UniProt", "db_id": "Q03506" }, { "db_name": "UniProt", "db_id": "Q08638" }, { "db_name": "UniProt", "db_id": "Q46684" }, { "db_name": "UniProt", "db_id": "Q56078" } ] } ]
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DS.d692
18679731
[ { "id": "DS.d692.s0", "type": "", "text": [ "As metabolic flux for the operation of the flavonoid pathway is maintained through the activities of PAL and C4H, thus, catechins biosynthesis in tea is critically dependent on the products of these enzymes." ], "offsets": [ [ 0, 207 ] ] } ]
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DS.d693
18679812
[ { "id": "DS.d693.s0", "type": "", "text": [ "Activities of antioxidant enzymes (superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, glutatione-S-transferase, and reduced glutathione) in liver also decreased in carcinogen-administered rats, which were significantly elevated in bacoside A-pretreated rats." ], "offsets": [ [ 0, 286 ] ] } ]
[ { "id": "DS.d693.s0.e0", "type": "protein", "text": [ "superoxide dismutase" ], "offsets": [ [ 35, 55 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O50258" } ] }, { "id": "DS.d693.s0.e1", "type": "protein", "text": [ "catalase" ], "offsets": [ [ 57, 65 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O24339" }, { "db_name": "UniProt", "db_id": "O52762" }, { "db_name": "UniProt", "db_id": "O62839" }, { "db_name": "UniProt", "db_id": "O68146" }, { "db_name": "UniProt", "db_id": "O77229" }, { "db_name": "UniProt", "db_id": "O93662" }, { "db_name": "UniProt", "db_id": "O97492" }, { "db_name": "UniProt", "db_id": "P00432" }, { "db_name": "UniProt", "db_id": "P04040" }, { "db_name": "UniProt", "db_id": "P04762" }, { "db_name": "UniProt", "db_id": "P07145" }, { "db_name": "UniProt", "db_id": "P0A323" }, { "db_name": "UniProt", "db_id": "P0A324" }, { "db_name": "UniProt", "db_id": "P0A325" }, { "db_name": "UniProt", "db_id": "P0A326" }, { "db_name": "UniProt", "db_id": "P0A327" }, { "db_name": "UniProt", "db_id": "P11934" }, { "db_name": "UniProt", "db_id": "P17336" }, { "db_name": "UniProt", "db_id": "P24168" }, { "db_name": "UniProt", "db_id": "P24270" }, { "db_name": "UniProt", "db_id": "P25890" }, { "db_name": "UniProt", "db_id": "P29422" }, { "db_name": "UniProt", "db_id": "P30265" }, { "db_name": "UniProt", "db_id": "P30266" }, { "db_name": "UniProt", "db_id": "P32290" }, { "db_name": "UniProt", "db_id": "P42321" }, { "db_name": "UniProt", "db_id": "P44390" }, { "db_name": "UniProt", "db_id": "P45737" }, { "db_name": "UniProt", "db_id": "P45739" }, { "db_name": "UniProt", "db_id": "P55304" }, { "db_name": "UniProt", "db_id": "P55306" }, { "db_name": "UniProt", "db_id": "P55310" }, { "db_name": "UniProt", "db_id": "P55311" }, { "db_name": "UniProt", "db_id": "P55313" }, { "db_name": "UniProt", "db_id": "P77872" }, { "db_name": "UniProt", "db_id": "P81138" }, { "db_name": "UniProt", "db_id": "P90682" }, { "db_name": "UniProt", "db_id": "Q27710" }, { "db_name": "UniProt", "db_id": "Q49XC1" }, { "db_name": "UniProt", "db_id": "Q4L643" }, { "db_name": "UniProt", "db_id": "Q59296" }, { "db_name": "UniProt", "db_id": "Q59337" }, { "db_name": "UniProt", "db_id": "Q59602" }, { "db_name": "UniProt", "db_id": "Q59714" }, { "db_name": "UniProt", "db_id": "Q5HG86" }, { "db_name": "UniProt", "db_id": "Q5HPK8" }, { "db_name": "UniProt", "db_id": "Q5RF10" }, { "db_name": "UniProt", "db_id": "Q64405" }, { "db_name": "UniProt", "db_id": "Q6G9M4" }, { "db_name": "UniProt", "db_id": "Q6GH72" }, { "db_name": "UniProt", "db_id": "Q7A5T2" }, { "db_name": "UniProt", "db_id": "Q8CPD0" }, { "db_name": "UniProt", "db_id": "Q8FWU0" }, { "db_name": "UniProt", "db_id": "Q8NWV5" }, { "db_name": "UniProt", "db_id": "Q8X1P0" }, { "db_name": "UniProt", "db_id": "Q8Y3P9" }, { "db_name": "UniProt", "db_id": "Q926X0" }, { "db_name": "UniProt", "db_id": "Q99UE2" }, { "db_name": "UniProt", "db_id": "Q9AXH0" }, { "db_name": "UniProt", "db_id": "Q9KW19" }, { "db_name": "UniProt", "db_id": "Q9L4S1" }, { "db_name": "UniProt", "db_id": "Q9M5L6" }, { "db_name": "UniProt", "db_id": "Q9PT92" }, { "db_name": "UniProt", "db_id": "Q9PWF7" }, { "db_name": "UniProt", "db_id": "Q9Z598" }, { "db_name": "UniProt", "db_id": "Q9ZKX5" }, { "db_name": "UniProt", "db_id": "Q9ZN99" } ] }, { "id": "DS.d693.s0.e2", "type": "protein", "text": [ "glutathione peroxidase" ], "offsets": [ [ 67, 89 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O32770" }, { "db_name": "UniProt", "db_id": "O59858" }, { "db_name": "UniProt", "db_id": "Q00277" }, { "db_name": "UniProt", "db_id": "Q9CFV1" } ] }, { "id": "DS.d693.s0.e3", "type": "protein", "text": [ "glutathione reductase" ], "offsets": [ [ 91, 112 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O15770" }, { "db_name": "UniProt", "db_id": "P06715" }, { "db_name": "UniProt", "db_id": "P11804" }, { "db_name": "UniProt", "db_id": "P23189" }, { "db_name": "UniProt", "db_id": "P41921" }, { "db_name": "UniProt", "db_id": "P43783" }, { "db_name": "UniProt", "db_id": "P48638" }, { "db_name": "UniProt", "db_id": "P48639" }, { "db_name": "UniProt", "db_id": "P70619" }, { "db_name": "UniProt", "db_id": "P78965" }, { "db_name": "UniProt", "db_id": "Q60151" }, { "db_name": "UniProt", "db_id": "Q6BPI1" }, { "db_name": "UniProt", "db_id": "Q6C5H4" }, { "db_name": "UniProt", "db_id": "Q6FRV2" }, { "db_name": "UniProt", "db_id": "Q6HA23" }, { "db_name": "UniProt", "db_id": "Q74ZK4" }, { "db_name": "UniProt", "db_id": "Q873E8" }, { "db_name": "UniProt", "db_id": "Q94655" } ] }, { "id": "DS.d693.s0.e4", "type": "compound", "text": [ "reduced glutathione" ], "offsets": [ [ 144, 163 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "124886" } ] } ]
[]
[]
[]
DS.d694
18679831
[ { "id": "DS.d694.s0", "type": "", "text": [ "In this study, we report that AR-M1896, a non-GalR1 agonist, inhibited plasma extravasation induced by substance P and calcitonin gene-related peptide in a manner similar to galanin, confirming a non-GalR1-mediated effect." ], "offsets": [ [ 0, 222 ] ] } ]
[ { "id": "DS.d694.s0.e0", "type": "compound", "text": [ "M1896" ], "offsets": [ [ 33, 38 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "77681" } ] }, { "id": "DS.d694.s0.e1", "type": "protein", "text": [ "substance P" ], "offsets": [ [ 103, 114 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01289" }, { "db_name": "UniProt", "db_id": "P06767" }, { "db_name": "UniProt", "db_id": "P19850" }, { "db_name": "UniProt", "db_id": "P20366" }, { "db_name": "UniProt", "db_id": "P28498" }, { "db_name": "UniProt", "db_id": "P28499" }, { "db_name": "UniProt", "db_id": "P41333" }, { "db_name": "UniProt", "db_id": "P41539" }, { "db_name": "UniProt", "db_id": "P41540" }, { "db_name": "UniProt", "db_id": "P67932" }, { "db_name": "UniProt", "db_id": "P67933" }, { "db_name": "UniProt", "db_id": "Q60541" } ] }, { "id": "DS.d694.s0.e2", "type": "protein", "text": [ "calcitonin gene-related peptide" ], "offsets": [ [ 119, 150 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P30880" }, { "db_name": "UniProt", "db_id": "P30881" }, { "db_name": "UniProt", "db_id": "P31888" } ] }, { "id": "DS.d694.s0.e3", "type": "protein", "text": [ "galanin" ], "offsets": [ [ 174, 181 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P07480" }, { "db_name": "UniProt", "db_id": "P10683" }, { "db_name": "UniProt", "db_id": "P11242" }, { "db_name": "UniProt", "db_id": "P22466" }, { "db_name": "UniProt", "db_id": "P30802" }, { "db_name": "UniProt", "db_id": "P31234" }, { "db_name": "UniProt", "db_id": "P33710" }, { "db_name": "UniProt", "db_id": "P47212" }, { "db_name": "UniProt", "db_id": "P47213" }, { "db_name": "UniProt", "db_id": "P47214" }, { "db_name": "UniProt", "db_id": "P47215" }, { "db_name": "UniProt", "db_id": "P47216" }, { "db_name": "UniProt", "db_id": "Q9W6M9" } ] } ]
[]
[]
[]
DS.d695
18680102
[ { "id": "DS.d695.s0", "type": "", "text": [ "Inhibition of non-small cell lung cancer cell migration by grape seed proanthocyanidins is mediated through the inhibition of nitric oxide, guanylate cyclase, and ERK1/2." ], "offsets": [ [ 0, 170 ] ] }, { "id": "DS.d695.s1", "type": "", "text": [ "Additionally, UO126 and ODQ inhibited the migration restoring effects of L-arginine in L-NAME-treated cells, suggesting the involvement of cGMP and MAPK pathways in NO-mediated migration." ], "offsets": [ [ 171, 358 ] ] }, { "id": "DS.d695.s2", "type": "", "text": [ "GSPs inhibited L-arginine and 8-Br-cGMP-induced activation of ERK1/2 in A549 cells." ], "offsets": [ [ 359, 442 ] ] } ]
[ { "id": "DS.d695.s0.e0", "type": "compound", "text": [ "proanthocyanidins" ], "offsets": [ [ 70, 87 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "108065" } ] }, { "id": "DS.d695.s0.e1", "type": "protein", "text": [ "cyclase" ], "offsets": [ [ 150, 157 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O94303" }, { "db_name": "UniProt", "db_id": "P33734" }, { "db_name": "UniProt", "db_id": "Q9P4P9" }, { "db_name": "UniProt", "db_id": "Q9SZ30" } ] }, { "id": "DS.d695.s0.e2", "type": "protein", "text": [ "ERK1" ], "offsets": [ [ 163, 167 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P27361" }, { "db_name": "UniProt", "db_id": "P28869" }, { "db_name": "UniProt", "db_id": "P42525" }, { "db_name": "UniProt", "db_id": "Q07176" } ] }, { "id": "DS.d695.s1.e0", "type": "compound", "text": [ "ODQ" ], "offsets": [ [ 195, 198 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1456" } ] }, { "id": "DS.d695.s1.e1", "type": "compound", "text": [ "L-arginine" ], "offsets": [ [ 244, 254 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6322" } ] }, { "id": "DS.d695.s1.e2", "type": "compound", "text": [ "cGMP" ], "offsets": [ [ 310, 314 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "24316" } ] }, { "id": "DS.d695.s1.e3", "type": "protein", "text": [ "MAPK" ], "offsets": [ [ 319, 323 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O42781" }, { "db_name": "UniProt", "db_id": "P27638" }, { "db_name": "UniProt", "db_id": "Q00859" } ] }, { "id": "DS.d695.s2.e0", "type": "compound", "text": [ "L-arginine" ], "offsets": [ [ 374, 384 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6322" } ] }, { "id": "DS.d695.s2.e1", "type": "compound", "text": [ "8-Br-cGMP" ], "offsets": [ [ 389, 398 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "104767" } ] }, { "id": "DS.d695.s2.e2", "type": "protein", "text": [ "ERK1" ], "offsets": [ [ 421, 425 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P27361" }, { "db_name": "UniProt", "db_id": "P28869" }, { "db_name": "UniProt", "db_id": "P42525" }, { "db_name": "UniProt", "db_id": "Q07176" } ] } ]
[]
[]
[ { "id": "DS.d695.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d695.s0.e0", "arg2_id": "DS.d695.s0.e2", "normalized": [] }, { "id": "DS.d695.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d695.s0.e0", "arg2_id": "DS.d695.s0.e1", "normalized": [] }, { "id": "DS.d695.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d695.s1.e0", "arg2_id": "DS.d695.s1.e3", "normalized": [] }, { "id": "DS.d695.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d695.s1.e1", "arg2_id": "DS.d695.s1.e3", "normalized": [] }, { "id": "DS.d695.s2.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d695.s2.e0", "arg2_id": "DS.d695.s2.e2", "normalized": [] }, { "id": "DS.d695.s2.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d695.s2.e1", "arg2_id": "DS.d695.s2.e2", "normalized": [] } ]
DS.d696
18680106
[ { "id": "DS.d696.s0", "type": "", "text": [ "Enhancement of p53 expression in keratinocytes by the bioflavonoid apigenin is associated with RNA-binding protein HuR." ], "offsets": [ [ 0, 119 ] ] }, { "id": "DS.d696.s1", "type": "", "text": [ "We have reported previously that apigenin, a naturally occurring nonmutagenic flavonoid, increased wild-type p53 protein expression in the mouse keratinocyte 308 cell line by a mechanism involving p53 protein stabilization." ], "offsets": [ [ 120, 343 ] ] }, { "id": "DS.d696.s2", "type": "", "text": [ "Instead, biosynthetic labeling showed that apigenin increased nascent p53 protein synthesis by enhancing p53 translation." ], "offsets": [ [ 344, 465 ] ] }, { "id": "DS.d696.s3", "type": "", "text": [ "Furthermore, apigenin treatment increased the level of association of the RNA binding protein HuR with endogenous p53 mRNA." ], "offsets": [ [ 466, 589 ] ] }, { "id": "DS.d696.s4", "type": "", "text": [ "Apigenin treatment also augmented HuR translocation into the cytoplasm." ], "offsets": [ [ 590, 661 ] ] }, { "id": "DS.d696.s5", "type": "", "text": [ "Overall, these findings indicate that, in addition to modulating p53 protein stability, one of the mechanisms by which apigenin induces p53 protein expression is enhancement of translation through the RNA binding protein HuR." ], "offsets": [ [ 662, 887 ] ] } ]
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"Q9TUB2" }, { "db_name": "UniProt", "db_id": "Q9W678" }, { "db_name": "UniProt", "db_id": "Q9W679" } ] }, { "id": "DS.d696.s0.e1", "type": "compound", "text": [ "bioflavonoid" ], "offsets": [ [ 54, 66 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5280805" } ] }, { "id": "DS.d696.s0.e2", "type": "compound", "text": [ "apigenin" ], "offsets": [ [ 67, 75 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5280443" } ] }, { "id": "DS.d696.s0.e3", "type": "protein", "text": [ "RNA-binding protein" ], "offsets": [ [ 95, 114 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P03526" }, { "db_name": "UniProt", "db_id": "P04487" }, { "db_name": "UniProt", "db_id": "P07940" }, { "db_name": "UniProt", "db_id": "P12002" }, { "db_name": "UniProt", "db_id": "P56958" }, { "db_name": "UniProt", "db_id": "P82866" } ] }, { "id": "DS.d696.s0.e4", "type": "protein", "text": [ "HuR" ], "offsets": [ [ 115, 118 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P70372" }, { "db_name": "UniProt", "db_id": "Q15717" } ] }, { "id": "DS.d696.s1.e0", "type": "compound", "text": [ "apigenin" ], "offsets": [ [ 153, 161 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5280443" } ] }, { "id": "DS.d696.s1.e1", "type": "compound", "text": [ "flavonoid" ], "offsets": [ [ 198, 207 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "10251" } ] }, { "id": "DS.d696.s1.e2", "type": "protein", "text": [ "p53" ], "offsets": [ [ 229, 232 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O09185" }, { "db_name": "UniProt", "db_id": "O12946" }, { "db_name": "UniProt", "db_id": "O57538" }, { "db_name": "UniProt", "db_id": "O93379" }, { "db_name": "UniProt", "db_id": "P02340" }, { "db_name": "UniProt", "db_id": "P04637" }, { "db_name": "UniProt", "db_id": "P10361" }, { "db_name": "UniProt", "db_id": "P19558" }, { "db_name": "UniProt", "db_id": "P19559" }, { "db_name": "UniProt", "db_id": "P56423" }, { "db_name": "UniProt", "db_id": "P56424" }, { "db_name": "UniProt", "db_id": 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"UniProt", "db_id": "P56423" }, { "db_name": "UniProt", "db_id": "P56424" }, { "db_name": "UniProt", "db_id": "P61260" }, { "db_name": "UniProt", "db_id": "P79820" }, { "db_name": "UniProt", "db_id": "P79892" }, { "db_name": "UniProt", "db_id": "Q29537" }, { "db_name": "UniProt", "db_id": "Q42578" }, { "db_name": "UniProt", "db_id": "Q8SPZ3" }, { "db_name": "UniProt", "db_id": "Q92143" }, { "db_name": "UniProt", "db_id": "Q9TTA1" }, { "db_name": "UniProt", "db_id": "Q9TUB2" }, { "db_name": "UniProt", "db_id": "Q9W678" }, { "db_name": "UniProt", "db_id": "Q9W679" } ] }, { "id": "DS.d696.s2.e0", "type": "compound", "text": [ "apigenin" ], "offsets": [ [ 387, 395 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5280443" } ] }, { "id": "DS.d696.s2.e1", "type": "protein", "text": [ "p53" ], "offsets": [ [ 414, 417 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O09185" }, { "db_name": "UniProt", "db_id": "O12946" }, { "db_name": "UniProt", "db_id": "O57538" }, { "db_name": "UniProt", "db_id": "O93379" }, { "db_name": "UniProt", "db_id": "P02340" }, { "db_name": "UniProt", "db_id": "P04637" }, { "db_name": "UniProt", "db_id": "P10361" }, { "db_name": "UniProt", "db_id": "P19558" }, { "db_name": "UniProt", "db_id": "P19559" }, { "db_name": "UniProt", "db_id": "P56423" }, { "db_name": "UniProt", "db_id": "P56424" }, { "db_name": "UniProt", "db_id": "P61260" }, { "db_name": "UniProt", "db_id": "P79820" }, { "db_name": "UniProt", "db_id": "P79892" }, { "db_name": "UniProt", "db_id": "Q29537" }, { "db_name": "UniProt", "db_id": "Q42578" }, { "db_name": "UniProt", "db_id": "Q8SPZ3" }, { "db_name": "UniProt", "db_id": "Q92143" }, { "db_name": "UniProt", "db_id": "Q9TTA1" }, { "db_name": "UniProt", "db_id": "Q9TUB2" }, { "db_name": "UniProt", "db_id": "Q9W678" }, { "db_name": "UniProt", "db_id": "Q9W679" } ] }, { "id": "DS.d696.s2.e2", "type": "protein", "text": [ "p53" ], "offsets": [ [ 449, 452 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O09185" }, { "db_name": "UniProt", "db_id": "O12946" }, { "db_name": "UniProt", "db_id": "O57538" }, { "db_name": "UniProt", "db_id": "O93379" }, { "db_name": "UniProt", "db_id": "P02340" }, { "db_name": "UniProt", "db_id": "P04637" }, { "db_name": "UniProt", "db_id": "P10361" }, { "db_name": "UniProt", "db_id": "P19558" }, { "db_name": "UniProt", "db_id": "P19559" }, { "db_name": "UniProt", "db_id": "P56423" }, { "db_name": "UniProt", "db_id": "P56424" }, { "db_name": "UniProt", "db_id": "P61260" }, { "db_name": "UniProt", "db_id": "P79820" }, { "db_name": "UniProt", "db_id": "P79892" }, { "db_name": "UniProt", "db_id": "Q29537" }, { "db_name": "UniProt", "db_id": "Q42578" }, { "db_name": "UniProt", "db_id": "Q8SPZ3" }, { "db_name": "UniProt", "db_id": "Q92143" }, { "db_name": "UniProt", "db_id": "Q9TTA1" }, { "db_name": "UniProt", "db_id": "Q9TUB2" }, { "db_name": "UniProt", "db_id": "Q9W678" }, { "db_name": "UniProt", "db_id": "Q9W679" } ] }, { "id": "DS.d696.s3.e0", "type": "compound", "text": [ "apigenin" ], "offsets": [ [ 479, 487 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5280443" } ] }, { "id": "DS.d696.s3.e1", "type": "protein", "text": [ "RNA binding protein" ], "offsets": [ [ 540, 559 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P03526" }, { "db_name": "UniProt", "db_id": "P04487" }, { "db_name": "UniProt", "db_id": "P07940" }, { "db_name": "UniProt", "db_id": "P12002" }, { "db_name": "UniProt", "db_id": "P56958" }, { "db_name": "UniProt", "db_id": "P82866" } ] }, { "id": "DS.d696.s3.e2", "type": "protein", "text": [ "HuR" ], "offsets": [ [ 560, 563 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P70372" }, { "db_name": "UniProt", "db_id": "Q15717" } ] }, { "id": "DS.d696.s3.e3", "type": "protein", "text": [ "p53" ], "offsets": [ [ 580, 583 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O09185" }, { "db_name": "UniProt", "db_id": "O12946" }, { "db_name": "UniProt", "db_id": "O57538" }, { "db_name": "UniProt", "db_id": "O93379" }, { "db_name": "UniProt", "db_id": "P02340" }, { "db_name": "UniProt", "db_id": "P04637" }, { "db_name": "UniProt", "db_id": "P10361" }, { "db_name": "UniProt", "db_id": "P19558" }, { "db_name": "UniProt", "db_id": "P19559" }, { "db_name": "UniProt", "db_id": "P56423" }, { "db_name": "UniProt", "db_id": "P56424" }, { "db_name": "UniProt", "db_id": "P61260" }, { "db_name": "UniProt", "db_id": "P79820" }, { "db_name": "UniProt", "db_id": "P79892" }, { "db_name": "UniProt", "db_id": "Q29537" }, { "db_name": "UniProt", "db_id": "Q42578" }, { "db_name": "UniProt", "db_id": "Q8SPZ3" }, { "db_name": "UniProt", "db_id": "Q92143" }, { "db_name": "UniProt", "db_id": "Q9TTA1" }, { "db_name": "UniProt", "db_id": "Q9TUB2" }, { "db_name": "UniProt", "db_id": "Q9W678" }, { "db_name": "UniProt", "db_id": "Q9W679" } ] }, { "id": "DS.d696.s4.e0", "type": "compound", "text": [ "Apigenin" ], "offsets": [ [ 590, 598 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5280443" } ] }, { "id": "DS.d696.s4.e1", "type": "protein", "text": [ "HuR" ], "offsets": [ [ 624, 627 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P70372" }, { "db_name": "UniProt", "db_id": "Q15717" } ] }, { "id": "DS.d696.s5.e0", "type": "protein", "text": [ "p53" ], "offsets": [ [ 727, 730 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O09185" }, { "db_name": "UniProt", "db_id": "O12946" }, { "db_name": "UniProt", "db_id": "O57538" }, { "db_name": "UniProt", "db_id": "O93379" }, { "db_name": "UniProt", "db_id": "P02340" }, { "db_name": "UniProt", "db_id": "P04637" }, { "db_name": "UniProt", "db_id": "P10361" }, { "db_name": "UniProt", "db_id": "P19558" }, { "db_name": "UniProt", "db_id": "P19559" }, { "db_name": "UniProt", "db_id": "P56423" }, { "db_name": "UniProt", "db_id": "P56424" }, { "db_name": "UniProt", "db_id": "P61260" }, { "db_name": "UniProt", "db_id": "P79820" }, { "db_name": "UniProt", "db_id": "P79892" }, { "db_name": "UniProt", "db_id": "Q29537" }, { "db_name": "UniProt", "db_id": "Q42578" }, { "db_name": "UniProt", "db_id": "Q8SPZ3" }, { "db_name": "UniProt", "db_id": "Q92143" }, { "db_name": "UniProt", "db_id": "Q9TTA1" }, { "db_name": "UniProt", "db_id": "Q9TUB2" }, { "db_name": "UniProt", "db_id": "Q9W678" }, { "db_name": "UniProt", "db_id": "Q9W679" } ] }, { "id": "DS.d696.s5.e1", "type": "compound", "text": [ "apigenin" ], "offsets": [ [ 781, 789 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5280443" } ] }, { "id": "DS.d696.s5.e2", "type": "protein", "text": [ "p53" ], "offsets": [ [ 798, 801 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O09185" }, { "db_name": "UniProt", "db_id": "O12946" }, { "db_name": "UniProt", "db_id": "O57538" }, { "db_name": "UniProt", "db_id": "O93379" }, { "db_name": "UniProt", "db_id": "P02340" }, { "db_name": "UniProt", "db_id": "P04637" }, { "db_name": "UniProt", "db_id": "P10361" }, { "db_name": "UniProt", "db_id": "P19558" }, { "db_name": "UniProt", "db_id": "P19559" }, { "db_name": "UniProt", "db_id": 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"text": [ "HuR" ], "offsets": [ [ 883, 886 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P70372" }, { "db_name": "UniProt", "db_id": "Q15717" } ] } ]
[]
[]
[ { "id": "DS.d696.s0.i3", "type": "compound-protein-interaction", "arg1_id": "DS.d696.s0.e2", "arg2_id": "DS.d696.s0.e4", "normalized": [] }, { "id": "DS.d696.s0.i4", "type": "compound-protein-interaction", "arg1_id": "DS.d696.s0.e2", "arg2_id": "DS.d696.s0.e0", "normalized": [] }, { "id": "DS.d696.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d696.s1.e0", "arg2_id": "DS.d696.s1.e2", "normalized": [] }, { "id": "DS.d696.s2.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d696.s2.e0", "arg2_id": "DS.d696.s2.e1", "normalized": [] }, { "id": "DS.d696.s3.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d696.s3.e0", "arg2_id": "DS.d696.s3.e3", "normalized": [] }, { "id": "DS.d696.s3.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d696.s3.e0", "arg2_id": "DS.d696.s3.e2", "normalized": [] }, { "id": "DS.d696.s4.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d696.s4.e0", "arg2_id": "DS.d696.s4.e1", "normalized": [] }, { "id": "DS.d696.s5.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d696.s5.e1", "arg2_id": "DS.d696.s5.e0", "normalized": [] }, { "id": "DS.d696.s5.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d696.s5.e1", "arg2_id": "DS.d696.s5.e4", "normalized": [] } ]
DS.d697
18680156
[ { "id": "DS.d697.s0", "type": "", "text": [ "Immunoblot analysis of signaling molecules, including cyclic-AMP response element binding protein (CREB), mitogen-activated protein kinases (MAPKp44/42; ERK1/2), in area CA1 revealed that thyroxin treatment reversed hypothyroidism-induced reduction of signaling molecules essential for learning and memory, and L-LTP." ], "offsets": [ [ 0, 317 ] ] } ]
[ { "id": "DS.d697.s0.e0", "type": "protein", "text": [ "AMP" ], "offsets": [ [ 61, 64 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O24006" } ] }, { "id": "DS.d697.s0.e1", "type": "protein", "text": [ "CREB" ], "offsets": [ [ 99, 103 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P15337" }, { "db_name": "UniProt", "db_id": "P16220" }, { "db_name": "UniProt", "db_id": "P27925" }, { "db_name": "UniProt", "db_id": "P51984" }, { "db_name": "UniProt", "db_id": "P51985" }, { "db_name": "UniProt", "db_id": "Q01147" } ] }, { "id": "DS.d697.s0.e2", "type": "protein", "text": [ "mitogen-activated protein kinases" ], "offsets": [ [ 106, 139 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q00859" } ] }, { "id": "DS.d697.s0.e3", "type": "protein", "text": [ "ERK1" ], "offsets": [ [ 153, 157 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P27361" }, { "db_name": "UniProt", "db_id": "P28869" }, { "db_name": "UniProt", "db_id": "P42525" }, { "db_name": "UniProt", "db_id": "Q07176" } ] }, { "id": "DS.d697.s0.e4", "type": "compound", "text": [ "thyroxin" ], "offsets": [ [ 188, 196 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5819" } ] } ]
[]
[]
[ { "id": "DS.d697.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d697.s0.e4", "arg2_id": "DS.d697.s0.e1", "normalized": [] }, { "id": "DS.d697.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d697.s0.e4", "arg2_id": "DS.d697.s0.e3", "normalized": [] }, { "id": "DS.d697.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d697.s0.e4", "arg2_id": "DS.d697.s0.e2", "normalized": [] } ]
DS.d698
18680550
[ { "id": "DS.d698.s0", "type": "", "text": [ "Insulin resistance is a major determinant of sustained virological response in genotype 1 chronic hepatitis C patients receiving peginterferon alpha-2b plus ribavirin." ], "offsets": [ [ 0, 167 ] ] }, { "id": "DS.d698.s1", "type": "", "text": [ "Aim To investigate retrospectively the impact of insulin resistance on treatment response in Chinese genotype 1 CHC patients receiving a 24-week course therapy with peginterferon alpha-2b/ribavirin." ], "offsets": [ [ 168, 366 ] ] } ]
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[]
[]
[ { "id": "DS.d698.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d698.s0.e1", "arg2_id": "DS.d698.s0.e0", "normalized": [] }, { "id": "DS.d698.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d698.s1.e1", "arg2_id": "DS.d698.s1.e0", "normalized": [] } ]
DS.d699
18680626
[ { "id": "DS.d699.s0", "type": "", "text": [ "We hypothesised that OAT could be a limiting step in glutamine-arginine interconversion." ], "offsets": [ [ 0, 88 ] ] }, { "id": "DS.d699.s1", "type": "", "text": [ "OAT overexpression decreased plasma and liver ornithine concentrations but did not affect glutamine or arginine homeostasis." ], "offsets": [ [ 89, 213 ] ] }, { "id": "DS.d699.s2", "type": "", "text": [ "There was an inverse relationship between ornithine levels and OAT activity." ], "offsets": [ [ 214, 290 ] ] } ]
[ { "id": "DS.d699.s0.e0", "type": "protein", "text": [ "OAT" ], "offsets": [ [ 21, 24 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P04181" }, { "db_name": "UniProt", "db_id": "Q07805" }, { "db_name": "UniProt", "db_id": "Q4XWV5" }, { "db_name": "UniProt", "db_id": "Q6LFH8" }, { "db_name": "UniProt", "db_id": "Q7RT90" } ] }, { "id": "DS.d699.s0.e1", "type": "compound", "text": [ "glutamine" ], "offsets": [ [ 53, 62 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "738" }, { "db_name": "PubChem", "db_id": "5961" } ] }, { "id": "DS.d699.s0.e2", "type": "compound", "text": [ "arginine" ], "offsets": [ [ 63, 71 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "232" }, { "db_name": "PubChem", "db_id": "4367" }, { "db_name": "PubChem", "db_id": "6322" } ] }, { "id": "DS.d699.s1.e0", "type": "protein", "text": [ "OAT" ], "offsets": [ [ 89, 92 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P04181" }, { "db_name": "UniProt", "db_id": "Q07805" }, { "db_name": "UniProt", "db_id": "Q4XWV5" }, { "db_name": "UniProt", "db_id": "Q6LFH8" }, { "db_name": "UniProt", "db_id": "Q7RT90" } ] }, { "id": "DS.d699.s1.e1", "type": "compound", "text": [ "ornithine" ], "offsets": [ [ 135, 144 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "389" }, { "db_name": "PubChem", "db_id": "6262" }, { "db_name": "PubChem", "db_id": "71082" } ] }, { "id": "DS.d699.s1.e2", "type": "compound", "text": [ "glutamine" ], "offsets": [ [ 179, 188 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "738" }, { "db_name": "PubChem", "db_id": "5961" } ] }, { "id": "DS.d699.s1.e3", "type": "compound", "text": [ "arginine" ], "offsets": [ [ 192, 200 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "232" }, { "db_name": "PubChem", "db_id": "4367" }, { "db_name": "PubChem", "db_id": "6322" } ] }, { "id": "DS.d699.s2.e0", "type": "compound", "text": [ "ornithine" ], "offsets": [ [ 256, 265 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "389" }, { "db_name": "PubChem", "db_id": "6262" }, { "db_name": "PubChem", "db_id": "71082" } ] }, { "id": "DS.d699.s2.e1", "type": "protein", "text": [ "OAT" ], "offsets": [ [ 277, 280 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P04181" }, { "db_name": "UniProt", "db_id": "Q07805" }, { "db_name": "UniProt", "db_id": "Q4XWV5" }, { "db_name": "UniProt", "db_id": "Q6LFH8" }, { "db_name": "UniProt", "db_id": "Q7RT90" } ] } ]
[]
[]
[ { "id": "DS.d699.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d699.s0.e1", "arg2_id": "DS.d699.s0.e0", "normalized": [] }, { "id": "DS.d699.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d699.s0.e2", "arg2_id": "DS.d699.s0.e0", "normalized": [] }, { "id": "DS.d699.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d699.s1.e1", "arg2_id": "DS.d699.s1.e0", "normalized": [] }, { "id": "DS.d699.s2.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d699.s2.e0", "arg2_id": "DS.d699.s2.e1", "normalized": [] } ]
DS.d700
18681858
[ { "id": "DS.d700.s0", "type": "", "text": [ "In men there is a large interindividual variation of SHBG levels and consequently of testosterone (T) and E(2) levels." ], "offsets": [ [ 0, 118 ] ] } ]
[ { "id": "DS.d700.s0.e0", "type": "protein", "text": [ "SHBG" ], "offsets": [ [ 53, 57 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P04278" }, { "db_name": "UniProt", "db_id": "P08689" }, { "db_name": "UniProt", "db_id": "P15196" }, { "db_name": "UniProt", "db_id": "P97497" }, { "db_name": "UniProt", "db_id": "Q62588" } ] }, { "id": "DS.d700.s0.e1", "type": "compound", "text": [ "testosterone" ], "offsets": [ [ 85, 97 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6013" } ] } ]
[]
[]
[ { "id": "DS.d700.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d700.s0.e1", "arg2_id": "DS.d700.s0.e0", "normalized": [] } ]
DS.d701
18682334
[ { "id": "DS.d701.s0", "type": "", "text": [ "Bone marrow cells were obtained from 5-day-old Muscovy ducks and cultured with (Group A) No added factors, (B) 30ng/mL soluble RANKL (sRANKL), (C) 30ng/mL sRANKL and 10ng/mL OPG, (D) 10ng/mL OPG, (E) 50ng/mL OPG, (F) 100ng/mL OPG and (G) 30ng/mL sRANKL, 6mmol/L Ca and 3mmol/L P. sRANKL promoted the survival of OCs on day 2, whereas the number of OCs decreased with addition of OPG in a dose-dependent manner." ], "offsets": [ [ 0, 410 ] ] } ]
[ { "id": "DS.d701.s0.e0", "type": "protein", "text": [ "RANKL" ], "offsets": [ [ 127, 132 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O14788" }, { "db_name": "UniProt", "db_id": "O35235" }, { "db_name": "UniProt", "db_id": "Q9ESE2" } ] }, { "id": "DS.d701.s0.e1", "type": "protein", "text": [ "OPG" ], "offsets": [ [ 174, 177 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O00300" } ] }, { "id": "DS.d701.s0.e2", "type": "protein", "text": [ "OPG" ], "offsets": [ [ 191, 194 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O00300" } ] }, { "id": "DS.d701.s0.e3", "type": "protein", "text": [ "OPG" ], "offsets": [ [ 191, 194 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O00300" } ] }, { "id": "DS.d701.s0.e4", "type": "protein", "text": [ "OPG" ], "offsets": [ [ 191, 194 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O00300" } ] }, { "id": "DS.d701.s0.e5", "type": "compound", "text": [ "L Ca" ], "offsets": [ [ 260, 264 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5281764" } ] }, { "id": "DS.d701.s0.e6", "type": "protein", "text": [ "OPG" ], "offsets": [ [ 191, 194 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O00300" } ] } ]
[]
[]
[]
DS.d702
18682988
[ { "id": "DS.d702.s0", "type": "", "text": [ "Over-expression of GDH decreased the yield of ethanol and 2,3-butanediol, meanwhile it increased the concentration of acetic acid." ], "offsets": [ [ 0, 130 ] ] } ]
[ { "id": "DS.d702.s0.e0", "type": "protein", "text": [ "GDH" ], "offsets": [ [ 19, 22 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O52310" }, { "db_name": "UniProt", "db_id": "O59650" }, { "db_name": "UniProt", "db_id": "O74024" }, { "db_name": "UniProt", "db_id": "O95479" }, { "db_name": "UniProt", "db_id": "P00366" }, { "db_name": "UniProt", "db_id": "P00367" }, { "db_name": "UniProt", "db_id": "P00368" }, { "db_name": "UniProt", "db_id": "P0AES2" }, { "db_name": "UniProt", "db_id": "P0AES3" }, { "db_name": "UniProt", "db_id": "P10860" }, { "db_name": "UniProt", "db_id": "P13443" }, { "db_name": "UniProt", "db_id": "P26443" }, { "db_name": "UniProt", "db_id": "P28270" }, { "db_name": "UniProt", "db_id": "P36234" }, { "db_name": "UniProt", "db_id": "P42174" }, { "db_name": "UniProt", "db_id": "P42206" }, { "db_name": "UniProt", "db_id": "P42238" }, { "db_name": "UniProt", "db_id": "P49448" }, { "db_name": "UniProt", "db_id": "P52596" }, { "db_name": "UniProt", "db_id": "P54385" }, { "db_name": "UniProt", "db_id": "P56201" }, { "db_name": "UniProt", "db_id": "P80319" }, { "db_name": "UniProt", "db_id": "P82264" }, { "db_name": "UniProt", "db_id": "P93541" }, { "db_name": "UniProt", "db_id": "P94598" }, { "db_name": "UniProt", "db_id": "P96110" }, { "db_name": "UniProt", "db_id": "Q09115" }, { "db_name": "UniProt", "db_id": "Q43260" }, { "db_name": "UniProt", "db_id": "Q47950" }, { "db_name": "UniProt", "db_id": "Q47951" }, { "db_name": "UniProt", "db_id": "Q53199" }, { "db_name": "UniProt", "db_id": "Q56304" }, { "db_name": "UniProt", "db_id": "Q59516" }, { "db_name": "UniProt", "db_id": "Q64HZ8" }, { "db_name": "UniProt", "db_id": "Q64HZ9" }, { "db_name": "UniProt", "db_id": "Q64I00" }, { "db_name": "UniProt", "db_id": "Q64I01" }, { "db_name": "UniProt", "db_id": "Q9HFR6" }, { "db_name": "UniProt", "db_id": "Q9HGU3" }, { "db_name": "UniProt", "db_id": "Q9HGU4" }, { "db_name": "UniProt", "db_id": "Q9RDE9" }, { "db_name": "UniProt", "db_id": "Q9URS1" }, { "db_name": "UniProt", "db_id": "Q9YC65" } ] }, { "id": "DS.d702.s0.e1", "type": "compound", "text": [ "ethanol" ], "offsets": [ [ 46, 53 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "702" } ] }, { "id": "DS.d702.s0.e2", "type": "compound", "text": [ "2,3-butanediol" ], "offsets": [ [ 58, 72 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "262" }, { "db_name": "PubChem", "db_id": "225936" } ] }, { "id": "DS.d702.s0.e3", "type": "compound", "text": [ "acetic acid" ], "offsets": [ [ 118, 129 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "176" }, { "db_name": "PubChem", "db_id": "286" }, { "db_name": "PubChem", "db_id": "291512" } ] } ]
[]
[]
[ { "id": "DS.d702.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d702.s0.e3", "arg2_id": "DS.d702.s0.e0", "normalized": [] }, { "id": "DS.d702.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d702.s0.e1", "arg2_id": "DS.d702.s0.e0", "normalized": [] }, { "id": "DS.d702.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d702.s0.e2", "arg2_id": "DS.d702.s0.e0", "normalized": [] } ]
DS.d703
18683011
[ { "id": "DS.d703.s0", "type": "", "text": [ "Geranylgeranylacetone prevents acute liver damage after massive hepatectomy in rats through suppression of a CXC chemokine GRO1 and induction of heat shock proteins." ], "offsets": [ [ 0, 165 ] ] } ]
[ { "id": "DS.d703.s0.e0", "type": "compound", "text": [ "Geranylgeranylacetone" ], "offsets": [ [ 0, 21 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5282199" } ] }, { "id": "DS.d703.s0.e1", "type": "protein", "text": [ "GRO1" ], "offsets": [ [ 123, 127 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P09341" } ] } ]
[]
[]
[ { "id": "DS.d703.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d703.s0.e0", "arg2_id": "DS.d703.s0.e1", "normalized": [] } ]
DS.d704
18683188
[ { "id": "DS.d704.s0", "type": "", "text": [ "Furthermore, HA induced dose-dependent elevation of reactive oxygen species (ROS) level in SMCs, and antioxidant vitamin C and Trolox effectively suppressed HA-induced DNA damage and dysregulation of Bcl-2/Bax." ], "offsets": [ [ 0, 210 ] ] } ]
[ { "id": "DS.d704.s0.e0", "type": "compound", "text": [ "oxygen" ], "offsets": [ [ 61, 67 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "977" } ] }, { "id": "DS.d704.s0.e1", "type": "compound", "text": [ "vitamin C" ], "offsets": [ [ 113, 122 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "54670067" } ] }, { "id": "DS.d704.s0.e2", "type": "compound", "text": [ "Trolox" ], "offsets": [ [ 127, 133 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "40634" } ] }, { "id": "DS.d704.s0.e3", "type": "protein", "text": [ "Bcl-2" ], "offsets": [ [ 200, 205 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P10417" }, { "db_name": "UniProt", "db_id": "P49950" } ] }, { "id": "DS.d704.s0.e4", "type": "protein", "text": [ "Bax" ], "offsets": [ [ 206, 209 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P27297" }, { "db_name": "UniProt", "db_id": "Q07813" }, { "db_name": "UniProt", "db_id": "Q63690" } ] } ]
[]
[]
[ { "id": "DS.d704.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d704.s0.e2", "arg2_id": "DS.d704.s0.e4", "normalized": [] }, { "id": "DS.d704.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d704.s0.e2", "arg2_id": "DS.d704.s0.e3", "normalized": [] }, { "id": "DS.d704.s0.i3", "type": "compound-protein-interaction", "arg1_id": "DS.d704.s0.e1", "arg2_id": "DS.d704.s0.e3", "normalized": [] }, { "id": "DS.d704.s0.i4", "type": "compound-protein-interaction", "arg1_id": "DS.d704.s0.e1", "arg2_id": "DS.d704.s0.e4", "normalized": [] } ]
DS.d705
18683221
[ { "id": "DS.d705.s0", "type": "", "text": [ "The adsorption of ovine fibrinogen onto PMA-modified surfaces was reduced relative to unmodified surfaces, and in vitro ovine blood contact through a rocking test revealed marked reductions in platelet deposition and bulk phase platelet activation relative to unmodified TiAl6V4 and polystyrene controls." ], "offsets": [ [ 0, 304 ] ] } ]
[ { "id": "DS.d705.s0.e0", "type": "protein", "text": [ "fibrinogen" ], "offsets": [ [ 24, 34 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P22775" }, { "db_name": "UniProt", "db_id": "P81070" } ] }, { "id": "DS.d705.s0.e1", "type": "compound", "text": [ "PMA" ], "offsets": [ [ 40, 43 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "27924" }, { "db_name": "PubChem", "db_id": "122634" }, { "db_name": "PubChem", "db_id": "22833501" } ] } ]
[]
[]
[ { "id": "DS.d705.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d705.s0.e1", "arg2_id": "DS.d705.s0.e0", "normalized": [] } ]
DS.d706
18683225
[ { "id": "DS.d706.s0", "type": "", "text": [ "When the thrombin concentration was higher than 15 U/mL, the gelation could be finished within 1 min and yielded a composite with evenly suspended and distributed PLGA microspheres." ], "offsets": [ [ 0, 181 ] ] } ]
[ { "id": "DS.d706.s0.e0", "type": "protein", "text": [ "thrombin" ], "offsets": [ [ 9, 17 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P84122" } ] }, { "id": "DS.d706.s0.e1", "type": "compound", "text": [ "PLGA" ], "offsets": [ [ 163, 167 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "36797" } ] } ]
[]
[]
[ { "id": "DS.d706.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d706.s0.e1", "arg2_id": "DS.d706.s0.e0", "normalized": [] } ]
DS.d707
18683233
[ { "id": "DS.d707.s0", "type": "", "text": [ "The culture tests using MSCs show that the level of alkaline phosphatase (ALP) activity in the cells cultured on SPV-H increased during the 21-day culture in a medium without Dex and beta-GP." ], "offsets": [ [ 0, 191 ] ] }, { "id": "DS.d707.s1", "type": "", "text": [ "The level was unchanged in MSCs cultured on PV-H. In the case of supplementing Dex and beta-GP to the medium, the level of ALP activity in MSCs cultured on SPV-H was higher than that on PV-H at all time points during the 21-day culture." ], "offsets": [ [ 192, 428 ] ] } ]
[ { "id": "DS.d707.s0.e0", "type": "protein", "text": [ "alkaline phosphatase" ], "offsets": [ [ 52, 72 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O60109" }, { "db_name": "UniProt", "db_id": "P81800" }, { "db_name": "UniProt", "db_id": "P83456" } ] }, { "id": "DS.d707.s0.e1", "type": "protein", "text": [ "ALP" ], "offsets": [ [ 74, 77 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P03973" }, { "db_name": "UniProt", "db_id": "P12547" }, { "db_name": "UniProt", "db_id": "P22298" }, { "db_name": "UniProt", "db_id": "P28296" }, { "db_name": "UniProt", "db_id": "P29118" }, { "db_name": "UniProt", "db_id": "P35211" }, { "db_name": "UniProt", "db_id": "P83610" }, { "db_name": "UniProt", "db_id": "P97430" }, { "db_name": "UniProt", "db_id": "Q03420" }, { "db_name": "UniProt", "db_id": "Q53GG5" }, { "db_name": "UniProt", "db_id": "Q9H0A0" }, { "db_name": "UniProt", "db_id": "Q9PU47" }, { "db_name": "UniProt", "db_id": "Q9Z1X0" } ] }, { "id": "DS.d707.s0.e2", "type": "compound", "text": [ "beta-GP" ], "offsets": [ [ 183, 190 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2526" } ] }, { "id": "DS.d707.s1.e0", "type": "compound", "text": [ "beta-GP" ], "offsets": [ [ 279, 286 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2526" } ] }, { "id": "DS.d707.s1.e1", "type": "protein", "text": [ "ALP" ], "offsets": [ [ 315, 318 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P03973" }, { "db_name": "UniProt", "db_id": "P12547" }, { "db_name": "UniProt", "db_id": "P22298" }, { "db_name": "UniProt", "db_id": "P28296" }, { "db_name": "UniProt", "db_id": "P29118" }, { "db_name": "UniProt", "db_id": "P35211" }, { "db_name": "UniProt", "db_id": "P83610" }, { "db_name": "UniProt", "db_id": "P97430" }, { "db_name": "UniProt", "db_id": "Q03420" }, { "db_name": "UniProt", "db_id": "Q53GG5" }, { "db_name": "UniProt", "db_id": "Q9H0A0" }, { "db_name": "UniProt", "db_id": "Q9PU47" }, { "db_name": "UniProt", "db_id": "Q9Z1X0" } ] } ]
[]
[]
[ { "id": "DS.d707.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d707.s0.e2", "arg2_id": "DS.d707.s0.e1", "normalized": [] }, { "id": "DS.d707.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d707.s0.e2", "arg2_id": "DS.d707.s0.e0", "normalized": [] }, { "id": "DS.d707.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d707.s1.e0", "arg2_id": "DS.d707.s1.e1", "normalized": [] } ]
DS.d708
18683244
[ { "id": "DS.d708.s0", "type": "", "text": [ "The combined treatment strategy not only decreased ubiquitin-positive aggregation in striatum, alleviated polyglutamine aggregation formation, and reduced striatal volume, but also extended life span in the R6/2 animal model." ], "offsets": [ [ 0, 225 ] ] } ]
[ { "id": "DS.d708.s0.e0", "type": "protein", "text": [ "ubiquitin" ], "offsets": [ [ 51, 60 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O46543" }, { "db_name": "UniProt", "db_id": "P08565" }, { "db_name": "UniProt", "db_id": "P08618" }, { "db_name": "UniProt", "db_id": "P0C014" }, { "db_name": "UniProt", "db_id": "P0C072" }, { "db_name": "UniProt", "db_id": "P13117" }, { "db_name": "UniProt", "db_id": "P14624" }, { "db_name": "UniProt", "db_id": "P14792" }, { "db_name": "UniProt", "db_id": "P15174" }, { "db_name": "UniProt", "db_id": "P19848" }, { "db_name": "UniProt", "db_id": "P20685" }, { "db_name": "UniProt", "db_id": "P22589" }, { "db_name": "UniProt", "db_id": "P23324" }, { "db_name": "UniProt", "db_id": "P23398" }, { "db_name": "UniProt", "db_id": "P42739" }, { "db_name": "UniProt", "db_id": "P42740" }, { "db_name": "UniProt", "db_id": "P46574" }, { "db_name": "UniProt", "db_id": "P49634" }, { "db_name": "UniProt", "db_id": "P49635" }, { "db_name": "UniProt", "db_id": "P59263" }, { "db_name": "UniProt", "db_id": "P59669" }, { "db_name": "UniProt", "db_id": "P61862" }, { "db_name": "UniProt", "db_id": "P61863" }, { "db_name": "UniProt", "db_id": "P61864" }, { "db_name": "UniProt", "db_id": "P62972" }, { "db_name": "UniProt", "db_id": "P62973" }, { "db_name": "UniProt", "db_id": "P62974" }, { "db_name": "UniProt", "db_id": "P62975" }, { "db_name": "UniProt", "db_id": "P62976" }, { "db_name": "UniProt", "db_id": "P62977" }, { "db_name": "UniProt", "db_id": "P62988" }, { "db_name": "UniProt", "db_id": "P62989" }, { "db_name": "UniProt", "db_id": "P62990" }, { "db_name": "UniProt", "db_id": "P62991" }, { "db_name": "UniProt", "db_id": "P63049" }, { "db_name": "UniProt", "db_id": "P63051" }, { "db_name": "UniProt", "db_id": "P68195" }, { "db_name": "UniProt", "db_id": "P68196" }, { "db_name": "UniProt", "db_id": "P68197" }, { "db_name": "UniProt", "db_id": "P68198" }, { "db_name": "UniProt", "db_id": "P68199" }, { "db_name": "UniProt", "db_id": "P68201" }, { "db_name": "UniProt", "db_id": "P68204" }, { "db_name": "UniProt", "db_id": "P69308" }, { "db_name": "UniProt", "db_id": "P69309" }, { "db_name": "UniProt", "db_id": "P69310" }, { "db_name": "UniProt", "db_id": "P69311" }, { "db_name": "UniProt", "db_id": "P69312" }, { "db_name": "UniProt", "db_id": "P69313" }, { "db_name": "UniProt", "db_id": "P69314" }, { "db_name": "UniProt", "db_id": "P69315" }, { "db_name": "UniProt", "db_id": "P69316" }, { "db_name": "UniProt", "db_id": "P69317" }, { "db_name": "UniProt", "db_id": "P69318" }, { "db_name": "UniProt", "db_id": "P69319" }, { "db_name": "UniProt", "db_id": "P69320" }, { "db_name": "UniProt", "db_id": "P69321" }, { "db_name": "UniProt", "db_id": "P69322" }, { "db_name": "UniProt", "db_id": "P69323" }, { "db_name": "UniProt", "db_id": "P69324" }, { "db_name": "UniProt", "db_id": "P69325" }, { "db_name": "UniProt", "db_id": "P69326" }, { "db_name": "UniProt", "db_id": "P84589" }, { "db_name": "UniProt", "db_id": "Q05550" }, { "db_name": "UniProt", "db_id": "Q865C5" }, { "db_name": "UniProt", "db_id": "Q867C2" }, { "db_name": "UniProt", "db_id": "Q867C3" }, { "db_name": "UniProt", "db_id": "Q867C4" }, { "db_name": "UniProt", "db_id": "Q8MKD1" }, { "db_name": "UniProt", "db_id": "Q9Y848" } ] }, { "id": "DS.d708.s0.e1", "type": "compound", "text": [ "polyglutamine" ], "offsets": [ [ 106, 119 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5961" } ] } ]
[]
[]
[]
DS.d709
18683246
[ { "id": "DS.d709.s0", "type": "", "text": [ "Vasoactive intestinal peptide inhibits toll-like receptor 3-induced nitric oxide production in Schwann cells and subsequent sensory neuronal cell death in vitro." ], "offsets": [ [ 0, 161 ] ] } ]
[ { "id": "DS.d709.s0.e0", "type": "protein", "text": [ "Vasoactive intestinal peptide" ], "offsets": [ [ 0, 29 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01282" }, { "db_name": "UniProt", "db_id": "P01283" }, { "db_name": "UniProt", "db_id": "P01284" }, { "db_name": "UniProt", "db_id": "P04566" }, { "db_name": "UniProt", "db_id": "P09684" }, { "db_name": "UniProt", "db_id": "P09685" }, { "db_name": "UniProt", "db_id": "P32648" }, { "db_name": "UniProt", "db_id": "P32649" }, { "db_name": "UniProt", "db_id": "P39089" }, { "db_name": "UniProt", "db_id": "P45644" }, { "db_name": "UniProt", "db_id": "P48142" }, { "db_name": "UniProt", "db_id": "P48143" }, { "db_name": "UniProt", "db_id": "P63289" }, { "db_name": "UniProt", "db_id": "P63290" }, { "db_name": "UniProt", "db_id": "P63291" }, { "db_name": "UniProt", "db_id": "P81016" }, { "db_name": "UniProt", "db_id": "P81401" }, { "db_name": "UniProt", "db_id": "P84488" }, { "db_name": "UniProt", "db_id": "P84771" }, { "db_name": "UniProt", "db_id": "P84772" } ] }, { "id": "DS.d709.s0.e1", "type": "compound", "text": [ "nitric oxide" ], "offsets": [ [ 68, 80 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "145068" } ] } ]
[]
[]
[ { "id": "DS.d709.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d709.s0.e1", "arg2_id": "DS.d709.s0.e0", "normalized": [] } ]
DS.d710
18683252
[ { "id": "DS.d710.s0", "type": "", "text": [ "The GUS and LUC genes were chosen because they can be used as markers for the easy detection of transgenic plants, while histidine tail better enables the isolation of protein expressed in plant tissue." ], "offsets": [ [ 0, 202 ] ] } ]
[ { "id": "DS.d710.s0.e0", "type": "protein", "text": [ "GUS" ], "offsets": [ [ 4, 7 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P05804" } ] }, { "id": "DS.d710.s0.e1", "type": "compound", "text": [ "histidine" ], "offsets": [ [ 121, 130 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "773" }, { "db_name": "PubChem", "db_id": "6274" } ] } ]
[]
[]
[]
DS.d711
18683262
[ { "id": "DS.d711.s0", "type": "", "text": [ "Expression was performed in fusion to maltose binding protein using chemically defined minimal medium, followed by a single-step affinity capture and enzymatic cleavage using tobacco etch virus protease." ], "offsets": [ [ 0, 203 ] ] } ]
[ { "id": "DS.d711.s0.e0", "type": "compound", "text": [ "maltose" ], "offsets": [ [ 38, 45 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "294" }, { "db_name": "PubChem", "db_id": "6255" }, { "db_name": "PubChem", "db_id": "439186" }, { "db_name": "PubChem", "db_id": "439341" }, { "db_name": "PubChem", "db_id": "10991489" }, { "db_name": "PubChem", "db_id": "45109807" } ] }, { "id": "DS.d711.s0.e1", "type": "protein", "text": [ "protease" ], "offsets": [ [ 194, 202 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O41798" }, { "db_name": "UniProt", "db_id": "O89290" }, { "db_name": "UniProt", "db_id": "O89940" }, { "db_name": "UniProt", "db_id": "O91080" }, { "db_name": "UniProt", "db_id": "O93215" }, { "db_name": "UniProt", "db_id": "P03311" }, { "db_name": "UniProt", "db_id": "P03353" }, { "db_name": "UniProt", "db_id": "P03355" }, { "db_name": "UniProt", "db_id": "P03356" }, { "db_name": "UniProt", "db_id": "P03362" }, { "db_name": "UniProt", "db_id": "P03363" }, { "db_name": "UniProt", "db_id": "P03366" }, { "db_name": "UniProt", "db_id": "P03367" }, { "db_name": "UniProt", "db_id": "P03369" }, { "db_name": "UniProt", "db_id": "P03370" }, { "db_name": "UniProt", "db_id": "P04023" }, { "db_name": "UniProt", "db_id": "P04024" }, { "db_name": "UniProt", "db_id": "P04323" }, { "db_name": "UniProt", "db_id": "P04584" }, { "db_name": "UniProt", "db_id": "P04585" }, { "db_name": "UniProt", "db_id": "P04587" }, { "db_name": "UniProt", "db_id": "P04588" }, { "db_name": "UniProt", "db_id": "P04589" }, { "db_name": "UniProt", "db_id": "P05959" }, { "db_name": "UniProt", "db_id": "P05960" }, { "db_name": "UniProt", "db_id": "P05961" }, { "db_name": "UniProt", "db_id": "P05962" }, { "db_name": "UniProt", "db_id": "P07570" }, { "db_name": "UniProt", "db_id": "P0C210" }, { "db_name": "UniProt", "db_id": "P0C211" }, { "db_name": "UniProt", "db_id": "P10210" }, { "db_name": "UniProt", "db_id": "P10265" }, { "db_name": "UniProt", "db_id": "P10270" }, { "db_name": 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}, { "db_name": "UniProt", "db_id": "Q89928" }, { "db_name": "UniProt", "db_id": "Q8AII1" }, { "db_name": "UniProt", "db_id": "Q8I7P9" }, { "db_name": "UniProt", "db_id": "Q9IDV9" }, { "db_name": "UniProt", "db_id": "Q9Q720" }, { "db_name": "UniProt", "db_id": "Q9QBY3" }, { "db_name": "UniProt", "db_id": "Q9QBZ1" }, { "db_name": "UniProt", "db_id": "Q9QBZ5" }, { "db_name": "UniProt", "db_id": "Q9QSR3" }, { "db_name": "UniProt", "db_id": "Q9WC54" }, { "db_name": "UniProt", "db_id": "Q9WC63" }, { "db_name": "UniProt", "db_id": "Q9Y6I0" } ] } ]
[]
[]
[]
DS.d712
18683263
[ { "id": "DS.d712.s0", "type": "", "text": [ "The amplification of gltA gene encoding citrate synthase of TCA cycle was required for the efficient conversion of acetyl-CoA, generated during vanillin production from ferulic acid, to CoA, which is essential for vanillin production." ], "offsets": [ [ 0, 234 ] ] }, { "id": "DS.d712.s1", "type": "", "text": [ "The gltA amplification of the glyoxylate bypass in the icdA null mutant remarkably increased the production rate of vanillin with a little increase in the amount of vanillin production." ], "offsets": [ [ 235, 420 ] ] }, { "id": "DS.d712.s2", "type": "", "text": [ "The real synergistic effect of gltA amplification and icdA deletion was observed with use of XAD-2 resin reducing the toxicity of vanillin produced during culture." ], "offsets": [ [ 421, 584 ] ] } ]
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{ "db_name": "UniProt", "db_id": "P79089" } ] }, { "id": "DS.d712.s2.e2", "type": "compound", "text": [ "vanillin" ], "offsets": [ [ 551, 559 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1183" } ] } ]
[]
[]
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DS.d713
18683889
[ { "id": "DS.d713.s0", "type": "", "text": [ "Treatment of dermal fibroblasts with vitamin D(3) induced expression of BMP-4 (1.2+/-0.2, 1.7+/-0.2, and 1.8+/-0.2 relative fold increase) and BMP-6 (9.1+/-0.3, 23.3+/-2.1, and 30.4+/-3.0 relative fold increase) at 3, 14, and 21 days, respectively." ], "offsets": [ [ 0, 248 ] ] }, { "id": "DS.d713.s1", "type": "", "text": [ "Vitamin D(3) was also shown to induce the expression of the osteoblast-specific markers, alkaline phosphatase and osteocalcin, in a dose-dependent manner in human dermal fibroblasts." ], "offsets": [ [ 249, 431 ] ] } ]
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[]
[]
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DS.d714
18684212
[ { "id": "DS.d714.s0", "type": "", "text": [ "The aims of this study were: (i) to characterize the basal circadian rhythm of adrenocorticotropin hormone (ACTH) and cortisol in IBS vs healthy controls; (ii) to compare stimulated ACTH, cortisol and noradrenaline responses to a pelvic visceral stressor (sigmoidoscopy) in IBS and controls; and (iii) to correlate neuroendocrine responses with colonic mucosal cytokine expression and symptoms in IBS." ], "offsets": [ [ 0, 401 ] ] }, { "id": "DS.d714.s1", "type": "", "text": [ "In Study 1, basal cortisol levels were analysed in 41 IBS and 25 controls using 24-h collections of plasma ACTH and cortisol (q10 min sampling)." ], "offsets": [ [ 402, 546 ] ] }, { "id": "DS.d714.s2", "type": "", "text": [ "Basal ACTH 0.05), while basal and stimulated plasma cortisol levels were higher in patients." ], "offsets": [ [ 547, 639 ] ] } ]
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"P06299" }, { "db_name": "UniProt", "db_id": "P10000" }, { "db_name": "UniProt", "db_id": "P11280" }, { "db_name": "UniProt", "db_id": "P11885" }, { "db_name": "UniProt", "db_id": "P19402" }, { "db_name": "UniProt", "db_id": "P21252" }, { "db_name": "UniProt", "db_id": "P22923" }, { "db_name": "UniProt", "db_id": "P68000" }, { "db_name": "UniProt", "db_id": "P68001" }, { "db_name": "UniProt", "db_id": "P87352" }, { "db_name": "UniProt", "db_id": "Q04617" }, { "db_name": "UniProt", "db_id": "Q04618" }, { "db_name": "UniProt", "db_id": "Q91082" }, { "db_name": "UniProt", "db_id": "Q9YGK2" }, { "db_name": "UniProt", "db_id": "Q9YGK4" }, { "db_name": "UniProt", "db_id": "Q9YGK5" } ] }, { "id": "DS.d714.s1.e2", "type": "compound", "text": [ "cortisol" ], "offsets": [ [ 518, 526 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5754" } ] }, { "id": "DS.d714.s2.e0", "type": "protein", "text": [ "ACTH" ], "offsets": [ [ 553, 557 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01189" }, { "db_name": "UniProt", "db_id": "P01190" }, { "db_name": "UniProt", "db_id": "P01191" }, { "db_name": "UniProt", "db_id": "P01192" }, { "db_name": "UniProt", "db_id": "P01193" }, { "db_name": "UniProt", "db_id": "P01194" }, { "db_name": "UniProt", "db_id": "P01196" }, { "db_name": "UniProt", "db_id": "P01197" }, { "db_name": "UniProt", "db_id": "P01201" }, { "db_name": "UniProt", "db_id": "P06297" }, { "db_name": "UniProt", "db_id": "P06298" }, { "db_name": "UniProt", "db_id": "P06299" }, { "db_name": "UniProt", "db_id": "P10000" }, { "db_name": "UniProt", "db_id": "P11280" }, { "db_name": "UniProt", "db_id": "P11885" }, { "db_name": "UniProt", "db_id": "P19402" }, { "db_name": "UniProt", "db_id": "P21252" }, { "db_name": "UniProt", "db_id": "P22923" }, { "db_name": "UniProt", "db_id": "P68000" }, { "db_name": "UniProt", "db_id": "P68001" }, { "db_name": "UniProt", "db_id": "P87352" }, { "db_name": "UniProt", "db_id": "Q04617" }, { "db_name": "UniProt", "db_id": "Q04618" }, { "db_name": "UniProt", "db_id": "Q91082" }, { "db_name": "UniProt", "db_id": "Q9YGK2" }, { "db_name": "UniProt", "db_id": "Q9YGK4" }, { "db_name": "UniProt", "db_id": "Q9YGK5" } ] }, { "id": "DS.d714.s2.e1", "type": "compound", "text": [ "cortisol" ], "offsets": [ [ 599, 607 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5754" } ] } ]
[]
[]
[]
DS.d715
18684339
[ { "id": "DS.d715.s0", "type": "", "text": [ "A 3-fold increase in the expression of the MnSOD gene was associated with decreased CpG methylation of the analysed promoter region in the vegetarian group compared with the age-matched omnivores group." ], "offsets": [ [ 0, 202 ] ] } ]
[ { "id": "DS.d715.s0.e0", "type": "protein", "text": [ "MnSOD" ], "offsets": [ [ 43, 48 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P00448" }, { "db_name": "UniProt", "db_id": "P66828" }, { "db_name": "UniProt", "db_id": "P66829" }, { "db_name": "UniProt", "db_id": "Q8Z2V9" }, { "db_name": "UniProt", "db_id": "Q9RUV2" } ] }, { "id": "DS.d715.s0.e1", "type": "compound", "text": [ "CpG" ], "offsets": [ [ 84, 87 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6804" } ] } ]
[]
[]
[]
DS.d716
18684712
[ { "id": "DS.d716.s0", "type": "", "text": [ "ALK2 (R206H) with Smad1 or Smad5 induced osteoblastic differentiation that could be inhibited by Smad7 or dorsomorphin." ], "offsets": [ [ 0, 119 ] ] } ]
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[]
[]
[ { "id": "DS.d716.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d716.s0.e4", "arg2_id": "DS.d716.s0.e1", "normalized": [] }, { "id": "DS.d716.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d716.s0.e4", "arg2_id": "DS.d716.s0.e2", "normalized": [] }, { "id": "DS.d716.s0.i3", "type": "compound-protein-interaction", "arg1_id": "DS.d716.s0.e4", "arg2_id": "DS.d716.s0.e0", "normalized": [] } ]
DS.d717
18685817
[ { "id": "DS.d717.s0", "type": "", "text": [ "Combustion products of 1,3-butadiene inhibit catalase activity and induce expression of oxidative DNA damage repair enzymes in human bronchial epithelial cells." ], "offsets": [ [ 0, 160 ] ] } ]
[ { "id": "DS.d717.s0.e0", "type": "compound", "text": [ "1,3-butadiene" ], "offsets": [ [ 23, 36 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "7845" } ] }, { "id": "DS.d717.s0.e1", "type": "protein", "text": [ "catalase" ], "offsets": [ [ 45, 53 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O24339" }, { "db_name": "UniProt", "db_id": "O52762" }, { "db_name": "UniProt", "db_id": "O62839" }, { "db_name": "UniProt", "db_id": "O68146" }, { "db_name": "UniProt", "db_id": "O77229" }, { "db_name": "UniProt", "db_id": "O93662" }, { "db_name": "UniProt", "db_id": "O97492" }, { "db_name": "UniProt", "db_id": "P00432" }, { "db_name": "UniProt", "db_id": "P04040" }, { "db_name": "UniProt", "db_id": "P04762" }, { "db_name": "UniProt", "db_id": "P07145" }, { "db_name": "UniProt", "db_id": "P0A323" }, { "db_name": "UniProt", "db_id": "P0A324" }, { "db_name": "UniProt", "db_id": "P0A325" }, { "db_name": "UniProt", "db_id": "P0A326" }, { "db_name": "UniProt", "db_id": "P0A327" }, { "db_name": "UniProt", "db_id": "P11934" }, { "db_name": "UniProt", "db_id": "P17336" }, { "db_name": "UniProt", "db_id": "P24168" }, { "db_name": "UniProt", "db_id": "P24270" }, { "db_name": "UniProt", "db_id": "P25890" }, { "db_name": "UniProt", "db_id": "P29422" }, { "db_name": "UniProt", "db_id": "P30265" }, { "db_name": "UniProt", "db_id": "P30266" }, { "db_name": "UniProt", "db_id": "P32290" }, { "db_name": "UniProt", "db_id": "P42321" }, { "db_name": "UniProt", "db_id": "P44390" }, { "db_name": "UniProt", "db_id": "P45737" }, { "db_name": "UniProt", "db_id": "P45739" }, { "db_name": "UniProt", "db_id": "P55304" }, { "db_name": "UniProt", "db_id": "P55306" }, { "db_name": "UniProt", "db_id": "P55310" }, { "db_name": "UniProt", "db_id": "P55311" }, { "db_name": "UniProt", "db_id": "P55313" }, { "db_name": "UniProt", "db_id": "P77872" }, { "db_name": "UniProt", "db_id": "P81138" }, { "db_name": "UniProt", "db_id": "P90682" }, { "db_name": "UniProt", "db_id": "Q27710" }, { "db_name": "UniProt", "db_id": "Q49XC1" }, { "db_name": "UniProt", "db_id": "Q4L643" }, { "db_name": "UniProt", "db_id": "Q59296" }, { "db_name": "UniProt", "db_id": "Q59337" }, { "db_name": "UniProt", "db_id": "Q59602" }, { "db_name": "UniProt", "db_id": "Q59714" }, { "db_name": "UniProt", "db_id": "Q5HG86" }, { "db_name": "UniProt", "db_id": "Q5HPK8" }, { "db_name": "UniProt", "db_id": "Q5RF10" }, { "db_name": "UniProt", "db_id": "Q64405" }, { "db_name": "UniProt", "db_id": "Q6G9M4" }, { "db_name": "UniProt", "db_id": "Q6GH72" }, { "db_name": "UniProt", "db_id": "Q7A5T2" }, { "db_name": "UniProt", "db_id": "Q8CPD0" }, { "db_name": "UniProt", "db_id": "Q8FWU0" }, { "db_name": "UniProt", "db_id": "Q8NWV5" }, { "db_name": "UniProt", "db_id": "Q8X1P0" }, { "db_name": "UniProt", "db_id": "Q8Y3P9" }, { "db_name": "UniProt", "db_id": "Q926X0" }, { "db_name": "UniProt", "db_id": "Q99UE2" }, { "db_name": "UniProt", "db_id": "Q9AXH0" }, { "db_name": "UniProt", "db_id": "Q9KW19" }, { "db_name": "UniProt", "db_id": "Q9L4S1" }, { "db_name": "UniProt", "db_id": "Q9M5L6" }, { "db_name": "UniProt", "db_id": "Q9PT92" }, { "db_name": "UniProt", "db_id": "Q9PWF7" }, { "db_name": "UniProt", "db_id": "Q9Z598" }, { "db_name": "UniProt", "db_id": "Q9ZKX5" }, { "db_name": "UniProt", "db_id": "Q9ZN99" } ] } ]
[]
[]
[]
DS.d718
18686014
[ { "id": "DS.d718.s0", "type": "", "text": [ "The aim of the present study was to examine whether increased serum Hsp70 levels are related to clinical characteristics and standard laboratory parameters of preeclamptic patients, as well as to markers of inflammation (C-reactive protein), endothelial activation (von Willebrand factor antigen) or endothelial injury (fibronectin), trophoblast debris (cell-free fetal DNA) and oxidative stress (malondialdehyde)." ], "offsets": [ [ 0, 414 ] ] }, { "id": "DS.d718.s1", "type": "", "text": [ "Furthermore, serum levels of blood urea nitrogen, creatinine, bilirubin and CRP, serum alanine aminotransferase and lactate dehydrogenase (LDH) activities, as well as plasma levels of VWF :Ag, fibronectin, cell-free fetal DNA and malondialdehyde were also significantly higher in preeclamptic patients than in normotensive, healthy pregnant women." ], "offsets": [ [ 415, 762 ] ] }, { "id": "DS.d718.s2", "type": "", "text": [ "In preeclamptic patients, serum Hsp70 levels showed significant correlations with serum CRP levels (Spearman R = 0.32, p = 0.010), serum aspartate aminotransferase (R = 0.32, p = 0.008) and LDH (0.001), as well as with plasma malondialdehyde levels (R = 0.25, p = 0.043)." ], "offsets": [ [ 763, 1034 ] ] } ]
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397, 412 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "10964" } ] }, { "id": "DS.d718.s1.e0", "type": "compound", "text": [ "urea" ], "offsets": [ [ 450, 454 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1176" }, { "db_name": "PubChem", "db_id": "265993" } ] }, { "id": "DS.d718.s1.e1", "type": "compound", "text": [ "nitrogen" ], "offsets": [ [ 455, 463 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "947" }, { "db_name": "PubChem", "db_id": "123329" } ] }, { "id": "DS.d718.s1.e2", "type": "compound", "text": [ "creatinine" ], "offsets": [ [ 465, 475 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "588" } ] }, { "id": "DS.d718.s1.e3", "type": "compound", "text": [ "bilirubin" ], "offsets": [ [ 477, 486 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5280352" } ] }, { "id": "DS.d718.s1.e4", "type": "protein", "text": [ "CRP" ], "offsets": [ [ 491, 494 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O19062" }, { "db_name": "UniProt", "db_id": "P02741" }, { "db_name": "UniProt", "db_id": "P02742" }, { "db_name": "UniProt", "db_id": "P08462" }, { "db_name": "UniProt", "db_id": "P18151" }, { "db_name": "UniProt", "db_id": "P21291" }, { "db_name": "UniProt", "db_id": "P41964" }, { "db_name": "UniProt", "db_id": "P47875" }, { "db_name": "UniProt", "db_id": "P49254" }, { "db_name": "UniProt", "db_id": "P49262" }, { "db_name": "UniProt", "db_id": "P52753" }, { "db_name": "UniProt", "db_id": "P67966" }, { "db_name": "UniProt", "db_id": "P67967" }, { "db_name": "UniProt", "db_id": "P97315" }, { "db_name": "UniProt", "db_id": "Q07203" } ] }, { "id": "DS.d718.s1.e5", "type": "protein", "text": [ "LDH" ], "offsets": [ [ 554, 557 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P29038" }, { "db_name": "UniProt", "db_id": "P33571" }, { "db_name": "UniProt", "db_id": "P93052" }, { "db_name": "UniProt", "db_id": "Q27797" }, { "db_name": "UniProt", "db_id": "Q27888" }, { "db_name": "UniProt", "db_id": "Q95028" }, { "db_name": "UniProt", "db_id": "Q99289" } ] }, { "id": "DS.d718.s1.e6", "type": "protein", "text": [ "VWF" ], "offsets": [ [ 599, 602 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P04275" }, { "db_name": "UniProt", "db_id": "P80012" }, { "db_name": "UniProt", "db_id": "Q28295" }, { "db_name": "UniProt", "db_id": "Q28833" }, { "db_name": "UniProt", "db_id": "Q8CIZ8" } ] }, { "id": "DS.d718.s1.e7", "type": "protein", "text": [ "fibronectin" ], "offsets": [ [ 608, 619 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P07589" }, { "db_name": "UniProt", "db_id": "P11722" }, { "db_name": "UniProt", "db_id": "Q28275" }, { "db_name": "UniProt", "db_id": "Q28377" }, { "db_name": "UniProt", "db_id": "Q28749" }, { "db_name": "UniProt", "db_id": "Q91289" }, { "db_name": "UniProt", "db_id": "Q91400" } ] }, { "id": "DS.d718.s1.e8", "type": "compound", "text": [ "malondialdehyde" ], "offsets": [ [ 645, 660 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "10964" } ] }, { "id": "DS.d718.s2.e0", "type": "protein", "text": [ "Hsp70" ], "offsets": [ [ 795, 800 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P30722" }, { "db_name": "UniProt", "db_id": "P47547" }, { "db_name": "UniProt", "db_id": "P49463" }, { "db_name": "UniProt", "db_id": "P75344" }, { "db_name": "UniProt", "db_id": "Q7YQC6" }, { "db_name": "UniProt", "db_id": "Q8TQR2" }, { "db_name": "UniProt", "db_id": "Q9UXR0" }, { "db_name": "UniProt", "db_id": "Q9WYK6" } ] }, { "id": "DS.d718.s2.e1", "type": "protein", "text": [ "CRP" ], "offsets": [ [ 851, 854 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O19062" }, { "db_name": "UniProt", "db_id": "P02741" }, { "db_name": "UniProt", "db_id": "P02742" }, { "db_name": "UniProt", "db_id": "P08462" }, { "db_name": "UniProt", "db_id": "P18151" }, { "db_name": "UniProt", "db_id": "P21291" }, { "db_name": "UniProt", "db_id": "P41964" }, { "db_name": "UniProt", "db_id": "P47875" }, { "db_name": "UniProt", "db_id": "P49254" }, { "db_name": "UniProt", "db_id": "P49262" }, { "db_name": "UniProt", "db_id": "P52753" }, { "db_name": "UniProt", "db_id": "P67966" }, { "db_name": "UniProt", "db_id": "P67967" }, { "db_name": "UniProt", "db_id": "P97315" }, { "db_name": "UniProt", "db_id": "Q07203" } ] }, { "id": "DS.d718.s2.e2", "type": "protein", "text": [ "aspartate aminotransferase" ], "offsets": [ [ 900, 926 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O33822" }, { "db_name": "UniProt", "db_id": "O58489" }, { "db_name": "UniProt", "db_id": "O67781" }, { "db_name": "UniProt", "db_id": "O86459" }, { "db_name": "UniProt", "db_id": "O93744" }, { "db_name": "UniProt", "db_id": "P00509" }, { "db_name": "UniProt", "db_id": "P14909" }, { "db_name": "UniProt", "db_id": "P23034" }, { "db_name": "UniProt", "db_id": "P44425" }, { "db_name": "UniProt", "db_id": "P53001" }, { "db_name": "UniProt", "db_id": "P58661" }, { "db_name": "UniProt", "db_id": "P72173" }, { "db_name": "UniProt", "db_id": "Q4J8X2" }, { "db_name": "UniProt", "db_id": "Q55128" }, { "db_name": "UniProt", "db_id": "Q56114" }, { "db_name": "UniProt", "db_id": "Q56232" }, { "db_name": "UniProt", "db_id": "Q59228" }, { "db_name": "UniProt", "db_id": "Q60013" }, { "db_name": "UniProt", "db_id": "Q92JE7" }, { "db_name": "UniProt", "db_id": "Q972A2" }, { "db_name": "UniProt", "db_id": "Q9V0L2" }, { "db_name": "UniProt", "db_id": "Q9X0Y2" }, { "db_name": "UniProt", "db_id": "Q9ZE56" } ] }, { "id": "DS.d718.s2.e3", "type": "protein", "text": [ "LDH" ], "offsets": [ [ 953, 956 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P29038" }, { "db_name": "UniProt", "db_id": "P33571" }, { "db_name": "UniProt", "db_id": "P93052" }, { "db_name": "UniProt", "db_id": "Q27797" }, { "db_name": "UniProt", "db_id": "Q27888" }, { "db_name": "UniProt", "db_id": "Q95028" }, { "db_name": "UniProt", "db_id": "Q99289" } ] }, { "id": "DS.d718.s2.e4", "type": "compound", "text": [ "malondialdehyde" ], "offsets": [ [ 989, 1004 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "10964" } ] } ]
[]
[]
[ { "id": "DS.d718.s2.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d718.s2.e4", "arg2_id": "DS.d718.s2.e0", "normalized": [] } ]
DS.d719
18686047
[ { "id": "DS.d719.s0", "type": "", "text": [ "In an effort to identify agents which enhance the activity of oligos and which possess less toxicity than traditionally employed chemotherapeutics, Rapamycin, an immunosuppressive agent known to regulate tumor growth and signal transduction mediated by the mTOR receptor, is compared to paclitaxel in combination therapy employing monospecific or bispecific oligos." ], "offsets": [ [ 0, 365 ] ] } ]
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[]
[]
[ { "id": "DS.d719.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d719.s0.e0", "arg2_id": "DS.d719.s0.e1", "normalized": [] } ]
DS.d720
18686136
[ { "id": "DS.d720.s0", "type": "", "text": [ "In this study we investigated the superoxide radicals scavenging effect and xanthine oxidase inhibitory activity by magnesium lithospermate B, which was originally isolated from the roots of Salvia miltiorrhiza (also named Danshen or Dansham), an important herb in Oriental medicine." ], "offsets": [ [ 0, 283 ] ] }, { "id": "DS.d720.s1", "type": "", "text": [ "Superoxide radicals were generated both in beta-NADH/PMS system and xanthine/xanthine oxidase system." ], "offsets": [ [ 284, 385 ] ] }, { "id": "DS.d720.s2", "type": "", "text": [ "Further study suggested that magnesium lithospermate B can directly inhibit xanthine oxidase and exhibits competitive inhibition." ], "offsets": [ [ 386, 515 ] ] }, { "id": "DS.d720.s3", "type": "", "text": [ "In addition, magnesium lithospermate B significantly protected HL-60 cells from superoxide radicals-induced apoptosis in the xanthine/xanthine oxidase reactions." ], "offsets": [ [ 516, 677 ] ] } ]
[ { "id": "DS.d720.s0.e0", "type": "compound", "text": [ "superoxide" ], "offsets": [ [ 34, 44 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5359597" } ] }, { "id": "DS.d720.s0.e1", "type": "protein", "text": [ "xanthine oxidase" ], "offsets": [ [ 76, 92 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P22985" }, { "db_name": "UniProt", "db_id": "P47989" }, { "db_name": "UniProt", "db_id": "P47990" }, { "db_name": "UniProt", "db_id": "P80457" }, { "db_name": "UniProt", "db_id": "Q00519" }, { "db_name": "UniProt", "db_id": "Q9MYW6" } ] }, { "id": "DS.d720.s0.e2", "type": "compound", "text": [ "magnesium lithospermate B" ], "offsets": [ [ 116, 141 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6451084" } ] }, { "id": "DS.d720.s1.e0", "type": "compound", "text": [ "Superoxide" ], "offsets": [ [ 284, 294 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5359597" } ] }, { "id": "DS.d720.s1.e1", "type": "compound", "text": [ "beta-NADH" ], "offsets": [ [ 327, 336 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "928" }, { "db_name": "PubChem", "db_id": "439153" }, { "db_name": "PubChem", "db_id": "11250888" } ] }, { "id": "DS.d720.s1.e2", "type": "compound", "text": [ "PMS" ], "offsets": [ [ 337, 340 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "9286" } ] }, { "id": "DS.d720.s1.e3", "type": "compound", "text": [ "xanthine" ], "offsets": [ [ 352, 360 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1188" } ] }, { "id": "DS.d720.s1.e4", "type": "protein", "text": [ "xanthine oxidase" ], "offsets": [ [ 361, 377 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P22985" }, { "db_name": "UniProt", "db_id": "P47989" }, { "db_name": "UniProt", "db_id": "P47990" }, { "db_name": "UniProt", "db_id": "P80457" }, { "db_name": "UniProt", "db_id": "Q00519" }, { "db_name": "UniProt", "db_id": "Q9MYW6" } ] }, { "id": "DS.d720.s2.e0", "type": "compound", "text": [ "magnesium lithospermate B" ], "offsets": [ [ 415, 440 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6451084" } ] }, { "id": "DS.d720.s2.e1", "type": "protein", "text": [ "xanthine oxidase" ], "offsets": [ [ 462, 478 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P22985" }, { "db_name": "UniProt", "db_id": "P47989" }, { "db_name": "UniProt", "db_id": "P47990" }, { "db_name": "UniProt", "db_id": "P80457" }, { "db_name": "UniProt", "db_id": "Q00519" }, { "db_name": "UniProt", "db_id": "Q9MYW6" } ] }, { "id": "DS.d720.s3.e0", "type": "compound", "text": [ "magnesium lithospermate B" ], "offsets": [ [ 529, 554 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6451084" } ] }, { "id": "DS.d720.s3.e1", "type": "compound", "text": [ "xanthine" ], "offsets": [ [ 641, 649 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1188" } ] }, { "id": "DS.d720.s3.e2", "type": "protein", "text": [ "xanthine oxidase" ], "offsets": [ [ 650, 666 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P22985" }, { "db_name": "UniProt", "db_id": "P47989" }, { "db_name": "UniProt", "db_id": "P47990" }, { "db_name": "UniProt", "db_id": "P80457" }, { "db_name": "UniProt", "db_id": "Q00519" }, { "db_name": "UniProt", "db_id": "Q9MYW6" } ] } ]
[]
[]
[ { "id": "DS.d720.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d720.s0.e2", "arg2_id": "DS.d720.s0.e1", "normalized": [] }, { "id": "DS.d720.s1.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d720.s1.e3", "arg2_id": "DS.d720.s1.e4", "normalized": [] }, { "id": "DS.d720.s1.i3", "type": "compound-protein-interaction", "arg1_id": "DS.d720.s1.e0", "arg2_id": "DS.d720.s1.e4", "normalized": [] }, { "id": "DS.d720.s2.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d720.s2.e0", "arg2_id": "DS.d720.s2.e1", "normalized": [] }, { "id": "DS.d720.s3.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d720.s3.e0", "arg2_id": "DS.d720.s3.e2", "normalized": [] }, { "id": "DS.d720.s3.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d720.s3.e1", "arg2_id": "DS.d720.s3.e2", "normalized": [] } ]
DS.d721
18686165
[ { "id": "DS.d721.s0", "type": "", "text": [ "Four different molecules contain galactofuranose in A. fumigatus: (i) the galactomannan present in the alkali soluble and insoluble fraction of the cell wall (ii) N- and O glycan moieties of secreted glycoproteins (iii) a GPI-anchored lipophosphogalactomannan and (iv) several sphingolipids also anchored to the membrane by an inositol phosphoceramide." ], "offsets": [ [ 0, 352 ] ] } ]
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"db_id": "Q9ZK49" } ] }, { "id": "DS.d721.s0.e4", "type": "compound", "text": [ "inositol phosphoceramide" ], "offsets": [ [ 327, 351 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "57339182" } ] } ]
[]
[]
[ { "id": "DS.d721.s0.i3", "type": "compound-protein-interaction", "arg1_id": "DS.d721.s0.e1", "arg2_id": "DS.d721.s0.e2", "normalized": [] } ]
DS.d722
18687549
[ { "id": "DS.d722.s0", "type": "", "text": [ "The estimated CRP level and the IMCL content in these patients were correlated with body mass index, percentage of body fat, other measures of abdominal obesity, serum lipoproteins, fasting and post-oral glucose load serum insulin levels and other surrogate markers of insulin resistance." ], "offsets": [ [ 0, 288 ] ] } ]
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[]
[]
[ { "id": "DS.d722.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d722.s0.e1", "arg2_id": "DS.d722.s0.e2", "normalized": [] } ]