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DS.d518
18624760
[ { "id": "DS.d518.s0", "type": "", "text": [ "Acitretin increased the levels of CD95 (Fas), CD95-ligand and Fas-associated death domain." ], "offsets": [ [ 0, 90 ] ] } ]
[ { "id": "DS.d518.s0.e0", "type": "compound", "text": [ "Acitretin" ], "offsets": [ [ 0, 9 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5284513" } ] }, { "id": "DS.d518.s0.e1", "type": "protein", "text": [ "Fas" ], "offsets": [ [ 40, 43 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P25446" }, { "db_name": "UniProt", "db_id": "Q63199" } ] }, { "id": "DS.d518.s0.e2", "type": "protein", "text": [ "Fas" ], "offsets": [ [ 62, 65 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P25446" }, { "db_name": "UniProt", "db_id": "Q63199" } ] } ]
[]
[]
[ { "id": "DS.d518.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d518.s0.e0", "arg2_id": "DS.d518.s0.e1", "normalized": [] } ]
DS.d519
18624766
[ { "id": "DS.d519.s0", "type": "", "text": [ "Since lithium and SB-415286-induced G(2)/M arrest we studied changes in the expression of proteins involved in this phase, specifically cyclin B, cdc2 and the phosphorylated form of this protein (tyr15-cdc2)." ], "offsets": [ [ 0, 208 ] ] }, { "id": "DS.d519.s1", "type": "", "text": [ "On the other hand, SB-415286 increased the expression of SIRT2, involved in the regulation of proliferation." ], "offsets": [ [ 209, 317 ] ] }, { "id": "DS.d519.s2", "type": "", "text": [ "We conclude that inhibitors of GSK-3 induced cell-cycle arrest, mediated by the phosphorylation of cdc2 and, in the case of SB-415286, SIRT2 expression, which induced apoptosis in a caspase-independent manner." ], "offsets": [ [ 318, 527 ] ] } ]
[ { "id": "DS.d519.s0.e0", "type": "compound", "text": [ "lithium" ], "offsets": [ [ 6, 13 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "28486" }, { "db_name": "PubChem", "db_id": "3028194" } ] }, { "id": "DS.d519.s0.e1", "type": "compound", "text": [ "SB-415286" ], "offsets": [ [ 18, 27 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "4210951" } ] }, { "id": "DS.d519.s0.e2", "type": "protein", "text": [ "cyclin" ], "offsets": [ [ 136, 142 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O01377" }, { "db_name": "UniProt", "db_id": "O16852" }, { "db_name": "UniProt", "db_id": "P04961" }, { "db_name": "UniProt", "db_id": "P12004" }, { "db_name": "UniProt", "db_id": "P17070" }, { "db_name": "UniProt", "db_id": "P17917" }, { "db_name": "UniProt", "db_id": "P17918" }, { "db_name": "UniProt", "db_id": "P18248" }, { "db_name": "UniProt", "db_id": "P22177" }, { "db_name": "UniProt", "db_id": "P24314" }, { "db_name": "UniProt", "db_id": "P31008" }, { "db_name": "UniProt", "db_id": "P53358" }, { "db_name": "UniProt", "db_id": "P61074" }, { "db_name": "UniProt", "db_id": "Q00265" }, { "db_name": "UniProt", "db_id": "Q00268" } ] }, { "id": "DS.d519.s0.e3", "type": "protein", "text": [ "cdc2" ], "offsets": [ [ 146, 150 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P04551" }, { "db_name": "UniProt", "db_id": "P11440" }, { "db_name": "UniProt", "db_id": "P23572" }, { "db_name": "UniProt", "db_id": "P39951" } ] }, { "id": "DS.d519.s0.e4", "type": "protein", "text": [ "cdc2" ], "offsets": [ [ 202, 206 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P04551" }, { "db_name": "UniProt", "db_id": "P11440" }, { "db_name": "UniProt", "db_id": "P23572" }, { "db_name": "UniProt", "db_id": "P39951" } ] }, { "id": "DS.d519.s1.e0", "type": "compound", "text": [ "SB-415286" ], "offsets": [ [ 228, 237 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "4210951" } ] }, { "id": "DS.d519.s1.e1", "type": "protein", "text": [ "SIRT2" ], "offsets": [ [ 266, 271 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q4R834" }, { "db_name": "UniProt", "db_id": "Q5RBF1" }, { "db_name": "UniProt", "db_id": "Q8IXJ6" } ] }, { "id": "DS.d519.s2.e0", "type": "protein", "text": [ "cdc2" ], "offsets": [ [ 417, 421 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P04551" }, { "db_name": "UniProt", "db_id": "P11440" }, { "db_name": "UniProt", "db_id": "P23572" }, { "db_name": "UniProt", "db_id": "P39951" } ] }, { "id": "DS.d519.s2.e1", "type": "compound", "text": [ "SB-415286" ], "offsets": [ [ 442, 451 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "4210951" } ] }, { "id": "DS.d519.s2.e2", "type": "protein", "text": [ "SIRT2" ], "offsets": [ [ 453, 458 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q4R834" }, { "db_name": "UniProt", "db_id": "Q5RBF1" }, { "db_name": "UniProt", "db_id": "Q8IXJ6" } ] } ]
[]
[]
[ { "id": "DS.d519.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d519.s1.e0", "arg2_id": "DS.d519.s1.e1", "normalized": [] }, { "id": "DS.d519.s2.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d519.s2.e1", "arg2_id": "DS.d519.s2.e2", "normalized": [] } ]
DS.d520
18624772
[ { "id": "DS.d520.s1", "type": "", "text": [ "Reduction of intracellular Ca(2+) levels abolished eNOS reduction by HOG-LDL, as did pharmacological or genetic through calcium channel blockers or calcium chelator BAPTA or inhibition of NAD(P)H oxidase (with apocynin) or inhibition of calpain (calpain 1-specific siRNA)." ], "offsets": [ [ 0, 272 ] ] } ]
[ { "id": "DS.d520.s1.e0", "type": "compound", "text": [ "Ca(2" ], "offsets": [ [ 27, 31 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "271" } ] }, { "id": "DS.d520.s1.e1", "type": "protein", "text": [ "eNOS" ], "offsets": [ [ 51, 55 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P29473" }, { "db_name": "UniProt", "db_id": "P29474" }, { "db_name": "UniProt", "db_id": "P70313" }, { "db_name": "UniProt", "db_id": "P79209" }, { "db_name": "UniProt", "db_id": "P97270" }, { "db_name": "UniProt", "db_id": "Q28969" }, { "db_name": "UniProt", "db_id": "Q62600" } ] }, { "id": "DS.d520.s1.e2", "type": "compound", "text": [ "BAPTA" ], "offsets": [ [ 165, 170 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "104751" } ] }, { "id": "DS.d520.s1.e3", "type": "compound", "text": [ "apocynin" ], "offsets": [ [ 210, 218 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2214" } ] } ]
[]
[]
[ { "id": "DS.d520.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d520.s1.e0", "arg2_id": "DS.d520.s1.e1", "normalized": [] }, { "id": "DS.d520.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d520.s1.e2", "arg2_id": "DS.d520.s1.e1", "normalized": [] } ]
DS.d521
18624794
[ { "id": "DS.d521.s0", "type": "", "text": [ "In addition to transporting glutamate, EAAC1 plays other roles in regulating GABA synthesis, reducing oxidative stress in neurons, and is important in supporting neuron viability." ], "offsets": [ [ 0, 179 ] ] } ]
[ { "id": "DS.d521.s0.e0", "type": "compound", "text": [ "glutamate" ], "offsets": [ [ 28, 37 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "611" }, { "db_name": "PubChem", "db_id": "23327" }, { "db_name": "PubChem", "db_id": "33032" } ] }, { "id": "DS.d521.s0.e1", "type": "protein", "text": [ "EAAC1" ], "offsets": [ [ 39, 44 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P31597" }, { "db_name": "UniProt", "db_id": "P43005" }, { "db_name": "UniProt", "db_id": "Q95135" } ] }, { "id": "DS.d521.s0.e2", "type": "compound", "text": [ "GABA" ], "offsets": [ [ 77, 81 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "119" } ] } ]
[]
[]
[ { "id": "DS.d521.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d521.s0.e0", "arg2_id": "DS.d521.s0.e1", "normalized": [] }, { "id": "DS.d521.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d521.s0.e2", "arg2_id": "DS.d521.s0.e1", "normalized": [] } ]
DS.d522
18625283
[ { "id": "DS.d522.s0", "type": "", "text": [ "Whereas both peptides lactoferricin (17-30) and lactoferrampin (265-284) did not have bactericidal activity, 40 microM of lactoferrin chimera (a fusion of the two peptides) inhibited the growth of all Vibrio tested to the same extent as the antibiotic gentamicin." ], "offsets": [ [ 0, 263 ] ] } ]
[ { "id": "DS.d522.s0.e0", "type": "compound", "text": [ "lactoferricin" ], "offsets": [ [ 22, 35 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "44567785" } ] }, { "id": "DS.d522.s0.e1", "type": "protein", "text": [ "lactoferrin" ], "offsets": [ [ 122, 133 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O77698" }, { "db_name": "UniProt", "db_id": "O77811" }, { "db_name": "UniProt", "db_id": "P02788" }, { "db_name": "UniProt", "db_id": "P08071" }, { "db_name": "UniProt", "db_id": "P14632" }, { "db_name": "UniProt", "db_id": "P24627" }, { "db_name": "UniProt", "db_id": "Q29477" }, { "db_name": "UniProt", "db_id": "Q9TUM0" } ] }, { "id": "DS.d522.s0.e2", "type": "compound", "text": [ "gentamicin" ], "offsets": [ [ 252, 262 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "3467" } ] } ]
[]
[]
[]
DS.d523
18625298
[ { "id": "DS.d523.s0", "type": "", "text": [ "We have recently shown that the antidepressant fluoxetine enhances T cell proliferation and T(H)1 cytokine production in vivo, without changes on CD4/CD8 subsets." ], "offsets": [ [ 0, 162 ] ] }, { "id": "DS.d523.s1", "type": "", "text": [ "We found that fluoxetine restored T cell proliferation and interleukin-2, interferon-gamma and tumor necrosis factor-alpha production by compensatory mechanisms." ], "offsets": [ [ 163, 324 ] ] } ]
[ { "id": "DS.d523.s0.e0", "type": "compound", "text": [ "fluoxetine" ], "offsets": [ [ 47, 57 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "3386" } ] }, { "id": "DS.d523.s0.e1", "type": "protein", "text": [ "CD4" ], "offsets": [ [ 146, 149 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01730" }, { "db_name": "UniProt", "db_id": "P05542" }, { "db_name": "UniProt", "db_id": "P16003" }, { "db_name": "UniProt", "db_id": "P16004" }, { "db_name": "UniProt", "db_id": "P33705" }, { "db_name": "UniProt", "db_id": "P46630" }, { "db_name": "UniProt", "db_id": "P79184" }, { "db_name": "UniProt", "db_id": "P79185" }, { "db_name": "UniProt", "db_id": "Q08336" }, { "db_name": "UniProt", "db_id": "Q08338" }, { "db_name": "UniProt", "db_id": "Q08339" }, { "db_name": "UniProt", "db_id": "Q08340" }, { "db_name": "UniProt", "db_id": "Q29037" }, { "db_name": "UniProt", "db_id": "Q9XS78" } ] }, { "id": "DS.d523.s1.e0", "type": "compound", "text": [ "fluoxetine" ], "offsets": [ [ 177, 187 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "3386" } ] }, { "id": "DS.d523.s1.e1", "type": "protein", "text": [ "interferon-gamma" ], "offsets": [ [ 237, 253 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q9TTB0" } ] }, { "id": "DS.d523.s1.e2", "type": "protein", "text": [ "tumor necrosis factor" ], "offsets": [ [ 258, 279 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q8JFG3" } ] } ]
[]
[]
[ { "id": "DS.d523.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d523.s1.e0", "arg2_id": "DS.d523.s1.e1", "normalized": [] }, { "id": "DS.d523.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d523.s1.e0", "arg2_id": "DS.d523.s1.e2", "normalized": [] } ]
DS.d524
18625569
[ { "id": "DS.d524.s0", "type": "", "text": [ "Here we report a case of intragenic EGFR microdeletion in renal cell carcinoma (RCC) associated with the effect of treatment by gefitinib." ], "offsets": [ [ 0, 138 ] ] } ]
[ { "id": "DS.d524.s0.e0", "type": "protein", "text": [ "EGFR" ], "offsets": [ [ 36, 40 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P00533" }, { "db_name": "UniProt", "db_id": "P13387" }, { "db_name": "UniProt", "db_id": "P55245" } ] }, { "id": "DS.d524.s0.e1", "type": "compound", "text": [ "gefitinib" ], "offsets": [ [ 128, 137 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "123631" } ] } ]
[]
[]
[ { "id": "DS.d524.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d524.s0.e1", "arg2_id": "DS.d524.s0.e0", "normalized": [] } ]
DS.d525
18626508
[ { "id": "DS.d525.s0", "type": "", "text": [ "Taking advantage of this prostate cancer-specific property of PSMA (E/P), we successfully introduced bacterial UPRT into LNCaP cells where the tumoricidal effect of 5-fluorouracil (5-FU) was significantly increased when compared with the cells without the exogenous UPRT." ], "offsets": [ [ 0, 271 ] ] } ]
[ { "id": "DS.d525.s0.e0", "type": "protein", "text": [ "UPRT" ], "offsets": [ [ 111, 115 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q26998" } ] }, { "id": "DS.d525.s0.e1", "type": "compound", "text": [ "5-fluorouracil" ], "offsets": [ [ 165, 179 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "3385" } ] }, { "id": "DS.d525.s0.e2", "type": "compound", "text": [ "5-FU" ], "offsets": [ [ 181, 185 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "3385" } ] }, { "id": "DS.d525.s0.e3", "type": "protein", "text": [ "UPRT" ], "offsets": [ [ 266, 270 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q26998" } ] } ]
[]
[]
[ { "id": "DS.d525.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d525.s0.e2", "arg2_id": "DS.d525.s0.e0", "normalized": [] }, { "id": "DS.d525.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d525.s0.e1", "arg2_id": "DS.d525.s0.e0", "normalized": [] } ]
DS.d526
18626658
[ { "id": "DS.d526.s0", "type": "", "text": [ "UCP2 is expressed in pancreatic beta cells where its postulated uncoupling activity will modulate glucose-induced changes in ATP/ADP ratio and insulin secretion." ], "offsets": [ [ 0, 161 ] ] }, { "id": "DS.d526.s2", "type": "", "text": [ "Neither UCP1 expression nor UCP2 overexpression modified basal or glucose-stimulated metabolic changes." ], "offsets": [ [ 162, 265 ] ] } ]
[ { "id": "DS.d526.s0.e0", "type": "protein", "text": [ "UCP2" ], "offsets": [ [ 0, 4 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O97562" }, { "db_name": "UniProt", "db_id": "P55851" }, { "db_name": "UniProt", "db_id": "Q9N2J1" }, { "db_name": "UniProt", "db_id": "Q9W725" } ] }, { "id": "DS.d526.s0.e1", "type": "compound", "text": [ "glucose" ], "offsets": [ [ 98, 105 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "206" }, { "db_name": "PubChem", "db_id": "5793" }, { "db_name": "PubChem", "db_id": "64689" }, { "db_name": "PubChem", "db_id": "79025" } ] }, { "id": "DS.d526.s0.e2", "type": "compound", "text": [ "ATP" ], "offsets": [ [ 125, 128 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5957" } ] }, { "id": "DS.d526.s0.e3", "type": "protein", "text": [ "insulin" ], "offsets": [ [ 143, 150 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01314" }, { "db_name": "UniProt", "db_id": "P01316" }, { "db_name": "UniProt", "db_id": "P01319" }, { "db_name": "UniProt", "db_id": "P01320" }, { "db_name": "UniProt", "db_id": "P01324" }, { "db_name": "UniProt", "db_id": "P01328" }, { "db_name": "UniProt", "db_id": "P01330" }, { "db_name": "UniProt", "db_id": "P01331" }, { "db_name": "UniProt", "db_id": "P01334" }, { "db_name": "UniProt", "db_id": "P01336" }, { "db_name": "UniProt", "db_id": "P01340" }, { "db_name": "UniProt", "db_id": "P07453" }, { "db_name": "UniProt", "db_id": "P09476" }, { "db_name": "UniProt", "db_id": "P09477" }, { "db_name": "UniProt", "db_id": "P0C236" }, { "db_name": "UniProt", "db_id": "P12703" }, { "db_name": "UniProt", "db_id": "P12704" }, { "db_name": "UniProt", "db_id": "P12708" }, { "db_name": "UniProt", "db_id": "P13190" }, { "db_name": "UniProt", "db_id": "P18109" }, { "db_name": "UniProt", "db_id": "P29335" }, { "db_name": "UniProt", "db_id": "P42633" }, { "db_name": "UniProt", "db_id": "P67968" }, { "db_name": "UniProt", "db_id": "P67969" }, { "db_name": "UniProt", "db_id": "P67971" }, { "db_name": "UniProt", "db_id": "P67973" }, { "db_name": "UniProt", "db_id": "P67974" }, { "db_name": "UniProt", "db_id": "P68243" }, { "db_name": "UniProt", "db_id": "P68245" }, { "db_name": "UniProt", "db_id": "P68987" }, { "db_name": "UniProt", "db_id": "P68988" }, { "db_name": "UniProt", "db_id": "P68989" }, { "db_name": "UniProt", "db_id": "P68990" }, { "db_name": "UniProt", "db_id": "P68991" }, { "db_name": "UniProt", "db_id": "P68992" }, { "db_name": "UniProt", "db_id": "P69046" }, { "db_name": "UniProt", "db_id": "P69047" }, { "db_name": "UniProt", "db_id": "P69048" }, { "db_name": "UniProt", "db_id": "P81423" }, { "db_name": "UniProt", "db_id": "P81881" }, { "db_name": "UniProt", "db_id": "Q9TQY7" } ] }, { "id": "DS.d526.s2.e0", "type": "protein", "text": [ "UCP1" ], "offsets": [ [ 170, 174 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P04575" }, { "db_name": "UniProt", "db_id": "P10861" }, { "db_name": "UniProt", "db_id": "P14271" }, { "db_name": "UniProt", "db_id": "P25874" }, { "db_name": "UniProt", "db_id": "Q18P97" }, { "db_name": "UniProt", "db_id": "Q8K404" }, { "db_name": "UniProt", "db_id": "Q9ER18" }, { "db_name": "UniProt", "db_id": "Q9GMZ1" } ] }, { "id": "DS.d526.s2.e1", "type": "protein", "text": [ "UCP2" ], "offsets": [ [ 190, 194 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O97562" }, { "db_name": "UniProt", "db_id": "P55851" }, { "db_name": "UniProt", "db_id": "Q9N2J1" }, { "db_name": "UniProt", "db_id": "Q9W725" } ] }, { "id": "DS.d526.s2.e2", "type": "compound", "text": [ "glucose" ], "offsets": [ [ 228, 235 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "206" }, { "db_name": "PubChem", "db_id": "5793" }, { "db_name": "PubChem", "db_id": "64689" }, { "db_name": "PubChem", "db_id": "79025" } ] } ]
[]
[]
[ { "id": "DS.d526.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d526.s0.e1", "arg2_id": "DS.d526.s0.e0", "normalized": [] }, { "id": "DS.d526.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d526.s0.e1", "arg2_id": "DS.d526.s0.e3", "normalized": [] }, { "id": "DS.d526.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d526.s0.e2", "arg2_id": "DS.d526.s0.e0", "normalized": [] } ]
DS.d527
18626709
[ { "id": "DS.d527.s0", "type": "", "text": [ "The chitinase activity was increased by Mn(2+), Cu(2+), and Mg(2+), while strongly inhibited by Fe(2+) and Ba(2+)." ], "offsets": [ [ 0, 114 ] ] }, { "id": "DS.d527.s1", "type": "", "text": [ "Meanwhile, SDS, ethyleneglycoltetraacetic acid, urea, and ethylenediaminetetraacetic acid were found to have significantly inhibitory effect on chitinase activity." ], "offsets": [ [ 115, 278 ] ] } ]
[ { "id": "DS.d527.s0.e0", "type": "protein", "text": [ "chitinase" ], "offsets": [ [ 4, 13 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P13656" }, { "db_name": "UniProt", "db_id": "P14529" }, { "db_name": "UniProt", "db_id": "P23472" }, { "db_name": "UniProt", "db_id": "P23473" }, { "db_name": "UniProt", "db_id": "P81241" }, { "db_name": "UniProt", "db_id": "P84754" } ] }, { "id": "DS.d527.s0.e1", "type": "compound", "text": [ "Mn(2" ], "offsets": [ [ 40, 44 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "27854" } ] }, { "id": "DS.d527.s0.e2", "type": "compound", "text": [ "Cu(2" ], "offsets": [ [ 48, 52 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "27099" } ] }, { "id": "DS.d527.s0.e3", "type": "compound", "text": [ "Fe(2" ], "offsets": [ [ 96, 100 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "27284" } ] }, { "id": "DS.d527.s0.e4", "type": "compound", "text": [ "Ba(2" ], "offsets": [ [ 107, 111 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "104810" } ] }, { "id": "DS.d527.s1.e0", "type": "compound", "text": [ "urea" ], "offsets": [ [ 163, 167 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1176" }, { "db_name": "PubChem", "db_id": "265993" } ] }, { "id": "DS.d527.s1.e1", "type": "compound", "text": [ "ethylenediaminetetraacetic acid" ], "offsets": [ [ 173, 204 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6049" } ] }, { "id": "DS.d527.s1.e2", "type": "protein", "text": [ "chitinase" ], "offsets": [ [ 259, 268 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P13656" }, { "db_name": "UniProt", "db_id": "P14529" }, { "db_name": "UniProt", "db_id": "P23472" }, { "db_name": "UniProt", "db_id": "P23473" }, { "db_name": "UniProt", "db_id": "P81241" }, { "db_name": "UniProt", "db_id": "P84754" } ] } ]
[]
[]
[ { "id": "DS.d527.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d527.s0.e2", "arg2_id": "DS.d527.s0.e0", "normalized": [] }, { "id": "DS.d527.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d527.s0.e1", "arg2_id": "DS.d527.s0.e0", "normalized": [] }, { "id": "DS.d527.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d527.s0.e4", "arg2_id": "DS.d527.s0.e0", "normalized": [] }, { "id": "DS.d527.s0.i3", "type": "compound-protein-interaction", "arg1_id": "DS.d527.s0.e3", "arg2_id": "DS.d527.s0.e0", "normalized": [] }, { "id": "DS.d527.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d527.s1.e1", "arg2_id": "DS.d527.s1.e2", "normalized": [] }, { "id": "DS.d527.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d527.s1.e0", "arg2_id": "DS.d527.s1.e2", "normalized": [] } ]
DS.d528
18626726
[ { "id": "DS.d528.s0", "type": "", "text": [ "In the present study, we screened the inhibitory effect of the extract from 50 Thai medicinal plants on an inducible-nitric oxide synthase (iNOS) expression induced by lipopolysaccharide (LPS) in mouse macrophages RAW 264.7." ], "offsets": [ [ 0, 224 ] ] } ]
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[]
[]
[ { "id": "DS.d528.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d528.s0.e2", "arg2_id": "DS.d528.s0.e1", "normalized": [] }, { "id": "DS.d528.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d528.s0.e2", "arg2_id": "DS.d528.s0.e0", "normalized": [] } ]
DS.d529
18626791
[ { "id": "DS.d529.s0", "type": "", "text": [ "Following thermal denaturation, rabbit reticulocyte lysate and ATP were added and luciferase activity measured." ], "offsets": [ [ 0, 111 ] ] } ]
[ { "id": "DS.d529.s0.e0", "type": "compound", "text": [ "ATP" ], "offsets": [ [ 63, 66 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5957" } ] }, { "id": "DS.d529.s0.e1", "type": "protein", "text": [ "luciferase" ], "offsets": [ [ 82, 92 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P08659" }, { "db_name": "UniProt", "db_id": "P13129" }, { "db_name": "UniProt", "db_id": "Q01158" }, { "db_name": "UniProt", "db_id": "Q26304" }, { "db_name": "UniProt", "db_id": "Q27757" } ] } ]
[]
[]
[]
DS.d530
18626794
[ { "id": "DS.d530.s0", "type": "", "text": [ "These results are in contrast to postmortem findings in schizophrenia and suggest that reduced synaptophysin protein levels in schizophrenia patients' postmortem brain do not result from perinatal oxygen deprivation." ], "offsets": [ [ 0, 216 ] ] } ]
[ { "id": "DS.d530.s0.e0", "type": "protein", "text": [ "synaptophysin" ], "offsets": [ [ 95, 108 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P07825" }, { "db_name": "UniProt", "db_id": "P08247" }, { "db_name": "UniProt", "db_id": "P20488" }, { "db_name": "UniProt", "db_id": "Q5YJC1" }, { "db_name": "UniProt", "db_id": "Q62277" } ] }, { "id": "DS.d530.s0.e1", "type": "compound", "text": [ "oxygen" ], "offsets": [ [ 197, 203 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "977" } ] } ]
[]
[]
[]
DS.d531
18627006
[ { "id": "DS.d531.s0", "type": "", "text": [ "We found that the acetylated histone H3 at lysine 9 and lysine 14 (H3K9/K14ac) is reduced in both the myelin basic protein (MBP) and proteolipid protein (PLP) genes of maturing oligodendroglial OL-1 cells, and furthermore, this temporally correlates with increases in MBP, PLP, and histone deacetylase (HDAC) 11 expression." ], "offsets": [ [ 0, 323 ] ] } ]
[ { "id": "DS.d531.s0.e0", "type": "protein", "text": [ "histone H3" ], "offsets": [ [ 29, 39 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P02299" }, { "db_name": "UniProt", "db_id": "P07041" }, { "db_name": "UniProt", "db_id": "P08437" }, { "db_name": "UniProt", "db_id": "P08898" }, { "db_name": "UniProt", "db_id": "P22843" }, { "db_name": "UniProt", "db_id": "P23753" }, { "db_name": "UniProt", "db_id": "P40285" }, { "db_name": "UniProt", "db_id": "P50564" }, { "db_name": "UniProt", "db_id": "P61830" }, { "db_name": "UniProt", "db_id": "P61831" }, { "db_name": "UniProt", "db_id": "P61832" }, { "db_name": "UniProt", "db_id": "P61833" }, { "db_name": "UniProt", "db_id": "P61834" }, { "db_name": "UniProt", "db_id": "P61835" }, { "db_name": "UniProt", "db_id": "P61836" }, { "db_name": "UniProt", "db_id": "P80553" }, { "db_name": "UniProt", "db_id": "P83864" }, { "db_name": "UniProt", "db_id": "P84235" }, { "db_name": "UniProt", "db_id": "P84236" }, { "db_name": "UniProt", "db_id": "P84237" }, { "db_name": "UniProt", "db_id": "P84238" }, { "db_name": "UniProt", "db_id": "P84239" }, { "db_name": "UniProt", "db_id": "P90543" }, { "db_name": "UniProt", "db_id": "Q06196" }, { "db_name": "UniProt", "db_id": "Q2UCQ0" }, { "db_name": "UniProt", "db_id": "Q5DWI3" }, { "db_name": "UniProt", "db_id": "Q757N1" }, { "db_name": "UniProt", "db_id": "Q7XYZ0" }, { "db_name": "UniProt", "db_id": "Q98RY4" }, { "db_name": "UniProt", "db_id": "Q9HDN1" }, { "db_name": "UniProt", "db_id": "Q9P427" }, { "db_name": "UniProt", "db_id": "Q9U7D1" } ] }, { "id": "DS.d531.s0.e1", "type": "compound", "text": [ "lysine" ], "offsets": [ [ 43, 49 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "866" }, { "db_name": "PubChem", "db_id": "5962" } ] }, { "id": "DS.d531.s0.e2", "type": "compound", "text": [ "lysine" ], "offsets": [ [ 56, 62 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "866" }, { "db_name": "PubChem", "db_id": "5962" } ] }, { "id": "DS.d531.s0.e3", "type": "protein", "text": [ "myelin basic protein" ], "offsets": [ [ 102, 122 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P02686" }, { "db_name": "UniProt", "db_id": "P02687" }, { "db_name": "UniProt", "db_id": "P04370" }, { "db_name": "UniProt", "db_id": "P06906" }, { "db_name": "UniProt", "db_id": "P15720" }, { "db_name": "UniProt", "db_id": "P20939" }, { "db_name": "UniProt", "db_id": "P25188" }, { "db_name": "UniProt", "db_id": "P25274" }, { "db_name": "UniProt", "db_id": "P81558" }, { "db_name": "UniProt", "db_id": "P83487" }, { "db_name": "UniProt", "db_id": "P87346" }, { "db_name": "UniProt", "db_id": "P98190" }, { "db_name": "UniProt", "db_id": "Q91325" }, { "db_name": "UniProt", "db_id": "Q91439" } ] }, { "id": "DS.d531.s0.e4", "type": "protein", "text": [ "MBP" ], "offsets": [ [ 124, 127 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P02686" }, { "db_name": "UniProt", "db_id": "P02687" }, { "db_name": "UniProt", "db_id": "P04370" }, { "db_name": "UniProt", "db_id": "P06906" }, { "db_name": "UniProt", "db_id": "P13727" }, { "db_name": "UniProt", "db_id": "P15720" }, { "db_name": "UniProt", "db_id": "P20939" }, { "db_name": "UniProt", "db_id": "P25188" }, { "db_name": "UniProt", "db_id": "P25274" }, { "db_name": "UniProt", "db_id": "P25336" }, { "db_name": "UniProt", "db_id": "P81558" }, { "db_name": "UniProt", "db_id": "P83487" }, { "db_name": "UniProt", "db_id": "P87346" }, { "db_name": "UniProt", "db_id": "P98190" }, { "db_name": "UniProt", "db_id": "Q61878" }, { "db_name": "UniProt", "db_id": "Q63189" }, { "db_name": "UniProt", "db_id": "Q91325" }, { "db_name": "UniProt", "db_id": "Q91439" }, { "db_name": "UniProt", "db_id": "Q9SAV1" } ] }, { "id": "DS.d531.s0.e5", "type": "protein", "text": [ "PLP" ], "offsets": [ [ 154, 157 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P04116" }, { "db_name": "UniProt", "db_id": "P13085" }, { "db_name": "UniProt", "db_id": "P22858" }, { "db_name": "UniProt", "db_id": "P23289" }, { "db_name": "UniProt", "db_id": "P23294" }, { "db_name": "UniProt", "db_id": "P30044" }, { "db_name": "UniProt", "db_id": "P47789" }, { "db_name": "UniProt", "db_id": "P47790" }, { "db_name": "UniProt", "db_id": "P60201" }, { "db_name": "UniProt", "db_id": "P60202" }, { "db_name": "UniProt", "db_id": "P60203" }, { "db_name": "UniProt", "db_id": "P79826" }, { "db_name": "UniProt", "db_id": "P80145" }, { "db_name": "UniProt", "db_id": "P99029" }, { "db_name": "UniProt", "db_id": "Q8HXW7" }, { "db_name": "UniProt", "db_id": "Q96GD0" }, { "db_name": "UniProt", "db_id": "Q9R063" } ] }, { "id": "DS.d531.s0.e6", "type": "protein", "text": [ "MBP" ], "offsets": [ [ 268, 271 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P02686" }, { "db_name": "UniProt", "db_id": "P02687" }, { "db_name": "UniProt", "db_id": "P04370" }, { "db_name": "UniProt", "db_id": "P06906" }, { "db_name": "UniProt", "db_id": "P13727" }, { "db_name": "UniProt", "db_id": "P15720" }, { "db_name": "UniProt", "db_id": "P20939" }, { "db_name": "UniProt", "db_id": "P25188" }, { "db_name": "UniProt", "db_id": "P25274" }, { "db_name": "UniProt", "db_id": "P25336" }, { "db_name": "UniProt", "db_id": "P81558" }, { "db_name": "UniProt", "db_id": "P83487" }, { "db_name": "UniProt", "db_id": "P87346" }, { "db_name": "UniProt", "db_id": "P98190" }, { "db_name": "UniProt", "db_id": "Q61878" }, { "db_name": "UniProt", "db_id": "Q63189" }, { "db_name": "UniProt", "db_id": "Q91325" }, { "db_name": "UniProt", "db_id": "Q91439" }, { "db_name": "UniProt", "db_id": "Q9SAV1" } ] }, { "id": "DS.d531.s0.e7", "type": "protein", "text": [ "PLP" ], "offsets": [ [ 273, 276 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P04116" }, { "db_name": "UniProt", "db_id": "P13085" }, { "db_name": "UniProt", "db_id": "P22858" }, { "db_name": "UniProt", "db_id": "P23289" }, { "db_name": "UniProt", "db_id": "P23294" }, { "db_name": "UniProt", "db_id": "P30044" }, { "db_name": "UniProt", "db_id": "P47789" }, { "db_name": "UniProt", "db_id": "P47790" }, { "db_name": "UniProt", "db_id": "P60201" }, { "db_name": "UniProt", "db_id": "P60202" }, { "db_name": "UniProt", "db_id": "P60203" }, { "db_name": "UniProt", "db_id": "P79826" }, { "db_name": "UniProt", "db_id": "P80145" }, { "db_name": "UniProt", "db_id": "P99029" }, { "db_name": "UniProt", "db_id": "Q8HXW7" }, { "db_name": "UniProt", "db_id": "Q96GD0" }, { "db_name": "UniProt", "db_id": "Q9R063" } ] }, { "id": "DS.d531.s0.e8", "type": "protein", "text": [ "histone deacetylase" ], "offsets": [ [ 282, 301 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O22446" } ] } ]
[]
[]
[ { "id": "DS.d531.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d531.s0.e1", "arg2_id": "DS.d531.s0.e0", "normalized": [] }, { "id": "DS.d531.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d531.s0.e1", "arg2_id": "DS.d531.s0.e4", "normalized": [] }, { "id": "DS.d531.s0.i3", "type": "compound-protein-interaction", "arg1_id": "DS.d531.s0.e1", "arg2_id": "DS.d531.s0.e3", "normalized": [] }, { "id": "DS.d531.s0.i4", "type": "compound-protein-interaction", "arg1_id": "DS.d531.s0.e1", "arg2_id": "DS.d531.s0.e5", "normalized": [] } ]
DS.d532
18627414
[ { "id": "DS.d532.s0", "type": "", "text": [ "Although the current studies associating particular genes and their variants with seizure control or adverse events have inherent weaknesses and have not provided unifying conclusions, several results, for example that Asian patients with a particular HLA allele, HLA-B *1502, are at a higher risk for Stevens-Johnson syndrome when using carbamazepine, are helpful to increase our knowledge how genetic variation affects the treatment of epilepsy." ], "offsets": [ [ 0, 447 ] ] } ]
[ { "id": "DS.d532.s0.e0", "type": "protein", "text": [ "HLA-B" ], "offsets": [ [ 264, 269 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01889" }, { "db_name": "UniProt", "db_id": "P03989" }, { "db_name": "UniProt", "db_id": "P10319" }, { "db_name": "UniProt", "db_id": "P18463" }, { "db_name": "UniProt", "db_id": "P18464" }, { "db_name": "UniProt", "db_id": "P18465" }, { "db_name": "UniProt", "db_id": "P30460" }, { "db_name": "UniProt", "db_id": "P30461" }, { "db_name": "UniProt", "db_id": "P30462" }, { "db_name": "UniProt", "db_id": "P30464" }, { "db_name": "UniProt", "db_id": "P30466" }, { "db_name": "UniProt", "db_id": "P30475" }, { "db_name": "UniProt", "db_id": "P30479" }, { "db_name": "UniProt", "db_id": "P30480" }, { "db_name": "UniProt", "db_id": "P30481" }, { "db_name": "UniProt", "db_id": "P30483" }, { "db_name": "UniProt", "db_id": "P30484" }, { "db_name": "UniProt", "db_id": "P30485" }, { "db_name": "UniProt", "db_id": "P30486" }, { "db_name": "UniProt", "db_id": "P30487" }, { "db_name": "UniProt", "db_id": "P30488" }, { "db_name": "UniProt", "db_id": "P30490" }, { "db_name": "UniProt", "db_id": "P30491" }, { "db_name": "UniProt", "db_id": "P30492" }, { "db_name": "UniProt", "db_id": "P30493" }, { "db_name": "UniProt", "db_id": "P30495" }, { "db_name": "UniProt", "db_id": "P30498" }, { "db_name": "UniProt", "db_id": "P30685" }, { "db_name": "UniProt", "db_id": "Q04826" }, { "db_name": "UniProt", "db_id": "Q29718" }, { "db_name": "UniProt", "db_id": "Q29836" }, { "db_name": "UniProt", "db_id": "Q29940" }, { "db_name": "UniProt", "db_id": "Q31610" }, { "db_name": "UniProt", "db_id": "Q31612" }, { "db_name": "UniProt", "db_id": "Q95365" } ] }, { "id": "DS.d532.s0.e1", "type": "compound", "text": [ "carbamazepine" ], "offsets": [ [ 338, 351 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2554" } ] } ]
[]
[]
[ { "id": "DS.d532.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d532.s0.e1", "arg2_id": "DS.d532.s0.e0", "normalized": [] } ]
DS.d533
18627421
[ { "id": "DS.d533.s0", "type": "", "text": [ "However, OPN-(/-) mice showed increased serum levels of tumour necrosis factor (TNF)-alpha, which could be due to systemically present lipopolysaccharide translocated to the gut." ], "offsets": [ [ 0, 178 ] ] } ]
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[]
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DS.d534
18627475
[ { "id": "DS.d534.s0", "type": "", "text": [ "The expression of the ERG1, ERG3, ERG7, ERG9, ERG11 and ERG25 genes in response to incubation with fluconazole and biofilm formation was investigated using reverse-transcription PCR and real-time PCR in Candida albicans and Candida dubliniensis clinical isolates." ], "offsets": [ [ 0, 263 ] ] }, { "id": "DS.d534.s1", "type": "", "text": [ "Expression of the ERG11 gene was found to be low or moderate and it was regulated by fluconazole addition more so than by biofilm formation." ], "offsets": [ [ 264, 404 ] ] }, { "id": "DS.d534.s2", "type": "", "text": [ "The expression of the ERG9 increased in the presence of fluconazole in some isolates." ], "offsets": [ [ 405, 490 ] ] } ]
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[]
[]
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DS.d535
18629545
[ { "id": "DS.d535.s0", "type": "", "text": [ "Concentrations of polyethylene glycol 1000 and Na2SO4 were selected as independent variables to evaluate their impact on parameters of partitioning in aqueous two-phase system--the partition coefficient of pectinase, purification factor and pectinase yield." ], "offsets": [ [ 0, 257 ] ] } ]
[ { "id": "DS.d535.s0.e0", "type": "compound", "text": [ "polyethylene glycol" ], "offsets": [ [ 18, 37 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "174" } ] }, { "id": "DS.d535.s0.e1", "type": "compound", "text": [ "Na2SO4" ], "offsets": [ [ 47, 53 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "24436" } ] }, { "id": "DS.d535.s0.e2", "type": "protein", "text": [ "pectinase" ], "offsets": [ [ 206, 215 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O42824" }, { "db_name": "UniProt", "db_id": "O59925" }, { "db_name": "UniProt", "db_id": "O93883" }, { "db_name": "UniProt", "db_id": "P05117" }, { "db_name": "UniProt", "db_id": "P20041" }, { "db_name": "UniProt", "db_id": "P24548" }, { "db_name": "UniProt", "db_id": "P26215" }, { "db_name": "UniProt", "db_id": "P26216" }, { "db_name": "UniProt", "db_id": "P27644" }, { "db_name": "UniProt", "db_id": "P35335" }, { "db_name": "UniProt", "db_id": "P35336" }, { "db_name": "UniProt", "db_id": "P35337" }, { "db_name": "UniProt", "db_id": "P35338" }, { "db_name": "UniProt", "db_id": "P35339" }, { "db_name": "UniProt", "db_id": "P41749" }, { "db_name": "UniProt", "db_id": "P41750" }, { "db_name": "UniProt", "db_id": "P43212" }, { "db_name": "UniProt", "db_id": "P47180" }, { "db_name": "UniProt", "db_id": "P48978" }, { "db_name": "UniProt", "db_id": "P48979" }, { "db_name": "UniProt", "db_id": "P49062" }, { "db_name": "UniProt", "db_id": "P49063" }, { "db_name": "UniProt", "db_id": "P49575" }, { "db_name": "UniProt", "db_id": "P58598" }, { "db_name": "UniProt", "db_id": "Q00446" }, { "db_name": "UniProt", "db_id": "Q02096" }, { "db_name": "UniProt", "db_id": "Q05967" }, { "db_name": "UniProt", "db_id": "Q07181" }, { "db_name": "UniProt", "db_id": "Q12708" }, { "db_name": "UniProt", "db_id": "Q39766" }, { "db_name": "UniProt", "db_id": "Q39786" }, { "db_name": "UniProt", "db_id": "Q40312" }, { "db_name": "UniProt", "db_id": "Q7M1E7" }, { "db_name": "UniProt", "db_id": "Q9FY19" }, { "db_name": "UniProt", "db_id": "Q9LW07" }, { "db_name": "UniProt", "db_id": "Q9Y718" } ] }, { "id": "DS.d535.s0.e3", "type": "protein", "text": [ "pectinase" ], "offsets": [ [ 241, 250 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O42824" }, { "db_name": "UniProt", "db_id": "O59925" }, { "db_name": "UniProt", "db_id": "O93883" }, { "db_name": "UniProt", "db_id": "P05117" }, { "db_name": "UniProt", "db_id": "P20041" }, { "db_name": "UniProt", "db_id": "P24548" }, { "db_name": "UniProt", "db_id": "P26215" }, { "db_name": "UniProt", "db_id": "P26216" }, { "db_name": "UniProt", "db_id": "P27644" }, { "db_name": "UniProt", "db_id": "P35335" }, { "db_name": "UniProt", "db_id": "P35336" }, { "db_name": "UniProt", "db_id": "P35337" }, { "db_name": "UniProt", "db_id": "P35338" }, { "db_name": "UniProt", "db_id": "P35339" }, { "db_name": "UniProt", "db_id": "P41749" }, { "db_name": "UniProt", "db_id": "P41750" }, { "db_name": "UniProt", "db_id": "P43212" }, { "db_name": "UniProt", "db_id": "P47180" }, { "db_name": "UniProt", "db_id": "P48978" }, { "db_name": "UniProt", "db_id": "P48979" }, { "db_name": "UniProt", "db_id": "P49062" }, { "db_name": "UniProt", "db_id": "P49063" }, { "db_name": "UniProt", "db_id": "P49575" }, { "db_name": "UniProt", "db_id": "P58598" }, { "db_name": "UniProt", "db_id": "Q00446" }, { "db_name": "UniProt", "db_id": "Q02096" }, { "db_name": "UniProt", "db_id": "Q05967" }, { "db_name": "UniProt", "db_id": "Q07181" }, { "db_name": "UniProt", "db_id": "Q12708" }, { "db_name": "UniProt", "db_id": "Q39766" }, { "db_name": "UniProt", "db_id": "Q39786" }, { "db_name": "UniProt", "db_id": "Q40312" }, { "db_name": "UniProt", "db_id": "Q7M1E7" }, { "db_name": "UniProt", "db_id": "Q9FY19" }, { "db_name": "UniProt", "db_id": "Q9LW07" }, { "db_name": "UniProt", "db_id": "Q9Y718" } ] } ]
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DS.d536
18629605
[ { "id": "DS.d536.s0", "type": "", "text": [ "In aged animals, administration of L-carnitine for 21 days significantly decreased the levels of lipid peroxides and improved the activities of antioxidant enzymes like superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase." ], "offsets": [ [ 0, 250 ] ] }, { "id": "DS.d536.s1", "type": "", "text": [ "L-Carnitine enhanced T-cell proliferative responses as evaluated by T-cell proliferation assay using (3H) thymidine incorporation and also significantly reduced DNA damage, apoptosis and TNF-alpha level in lymphocytes of aged animals." ], "offsets": [ [ 251, 485 ] ] } ]
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"db_id": "Q926X0" }, { "db_name": "UniProt", "db_id": "Q99UE2" }, { "db_name": "UniProt", "db_id": "Q9AXH0" }, { "db_name": "UniProt", "db_id": "Q9KW19" }, { "db_name": "UniProt", "db_id": "Q9L4S1" }, { "db_name": "UniProt", "db_id": "Q9M5L6" }, { "db_name": "UniProt", "db_id": "Q9PT92" }, { "db_name": "UniProt", "db_id": "Q9PWF7" }, { "db_name": "UniProt", "db_id": "Q9Z598" }, { "db_name": "UniProt", "db_id": "Q9ZKX5" }, { "db_name": "UniProt", "db_id": "Q9ZN99" } ] }, { "id": "DS.d536.s0.e3", "type": "protein", "text": [ "glutathione peroxidase" ], "offsets": [ [ 201, 223 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O32770" }, { "db_name": "UniProt", "db_id": "O59858" }, { "db_name": "UniProt", "db_id": "Q00277" }, { "db_name": "UniProt", "db_id": "Q9CFV1" } ] }, { "id": "DS.d536.s0.e4", "type": "protein", "text": [ "glutathione reductase" ], "offsets": [ [ 228, 249 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O15770" }, { "db_name": "UniProt", "db_id": "P06715" }, { "db_name": "UniProt", "db_id": "P11804" }, { "db_name": "UniProt", "db_id": "P23189" }, { "db_name": "UniProt", "db_id": "P41921" }, { "db_name": "UniProt", "db_id": "P43783" }, { "db_name": "UniProt", "db_id": "P48638" }, { "db_name": "UniProt", "db_id": "P48639" }, { "db_name": "UniProt", "db_id": "P70619" }, { "db_name": "UniProt", "db_id": "P78965" }, { "db_name": "UniProt", "db_id": "Q60151" }, { "db_name": "UniProt", "db_id": "Q6BPI1" }, { "db_name": "UniProt", "db_id": "Q6C5H4" }, { "db_name": "UniProt", "db_id": "Q6FRV2" }, { "db_name": "UniProt", "db_id": "Q6HA23" }, { "db_name": "UniProt", "db_id": "Q74ZK4" }, { "db_name": "UniProt", "db_id": "Q873E8" }, { "db_name": "UniProt", "db_id": "Q94655" } ] }, { "id": "DS.d536.s1.e0", "type": "compound", "text": [ "L-Carnitine" ], "offsets": [ [ 251, 262 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "10918" } ] }, { "id": "DS.d536.s1.e1", "type": "compound", "text": [ "thymidine" ], "offsets": [ [ 357, 366 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5789" } ] }, { "id": "DS.d536.s1.e2", "type": "protein", "text": [ "TNF-alpha" ], "offsets": [ [ 438, 447 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O35734" }, { "db_name": "UniProt", "db_id": "O77510" }, { "db_name": "UniProt", "db_id": "O77764" }, { "db_name": "UniProt", "db_id": "P01375" }, { "db_name": "UniProt", "db_id": "P04924" }, { "db_name": "UniProt", "db_id": "P06804" }, { "db_name": "UniProt", "db_id": "P13296" }, { "db_name": "UniProt", "db_id": "P16599" }, { "db_name": "UniProt", "db_id": "P19101" }, { "db_name": "UniProt", "db_id": "P23383" }, { "db_name": "UniProt", "db_id": "P23563" }, { "db_name": "UniProt", "db_id": "P29553" }, { "db_name": "UniProt", "db_id": "P33620" }, { "db_name": "UniProt", "db_id": "P36939" }, { "db_name": "UniProt", "db_id": "P48094" }, { "db_name": "UniProt", "db_id": "P51435" }, { "db_name": "UniProt", "db_id": "P51742" }, { "db_name": "UniProt", "db_id": "P51743" }, { "db_name": "UniProt", "db_id": "P59684" }, { "db_name": "UniProt", "db_id": "P59693" }, { "db_name": "UniProt", "db_id": "P59694" }, { "db_name": "UniProt", "db_id": "P59695" }, { "db_name": "UniProt", "db_id": "P79337" }, { "db_name": "UniProt", "db_id": "P79374" }, { "db_name": "UniProt", "db_id": "Q06599" }, { "db_name": "UniProt", "db_id": "Q19LH4" }, { "db_name": "UniProt", "db_id": "Q1G1A2" }, { "db_name": "UniProt", "db_id": "Q1WM27" }, { "db_name": "UniProt", "db_id": "Q2MH05" }, { "db_name": "UniProt", "db_id": "Q539C2" }, { "db_name": "UniProt", "db_id": "Q75N23" }, { "db_name": "UniProt", "db_id": "Q8HZD9" }, { "db_name": "UniProt", "db_id": "Q8JFG3" }, { "db_name": "UniProt", "db_id": "Q8MKG8" }, { "db_name": "UniProt", "db_id": "Q8WNR1" }, { "db_name": "UniProt", "db_id": "Q9BEA1" } ] } ]
[]
[]
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DS.d537
18629630
[ { "id": "DS.d537.s0", "type": "", "text": [ "In our microarray analysis we observed that Seven-in-Absentia Homolog 2 (SIAH2) levels were low in estrogen receptor (ER) positive breast tumors of patients resistant to first-line tamoxifen therapy." ], "offsets": [ [ 0, 199 ] ] } ]
[ { "id": "DS.d537.s0.e0", "type": "protein", "text": [ "Seven-in-Absentia Homolog 2" ], "offsets": [ [ 44, 71 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O43255" }, { "db_name": "UniProt", "db_id": "Q06986" }, { "db_name": "UniProt", "db_id": "Q8R4T2" }, { "db_name": "UniProt", "db_id": "Q9I8X5" }, { "db_name": "UniProt", "db_id": "Q9M2P4" } ] }, { "id": "DS.d537.s0.e1", "type": "protein", "text": [ "SIAH2" ], "offsets": [ [ 73, 78 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O43255" } ] }, { "id": "DS.d537.s0.e2", "type": "protein", "text": [ "estrogen receptor" ], "offsets": [ [ 99, 116 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O42132" }, { "db_name": "UniProt", "db_id": "P03372" }, { "db_name": "UniProt", "db_id": "P06211" }, { "db_name": "UniProt", "db_id": "P06212" }, { "db_name": "UniProt", "db_id": "P16058" }, { "db_name": "UniProt", "db_id": "P19785" }, { "db_name": "UniProt", "db_id": "P49884" }, { "db_name": "UniProt", "db_id": "P49885" }, { "db_name": "UniProt", "db_id": "P49886" }, { "db_name": "UniProt", "db_id": "P50240" }, { "db_name": "UniProt", "db_id": "P50241" }, { "db_name": "UniProt", "db_id": "P50242" }, { "db_name": "UniProt", "db_id": "P57717" }, { "db_name": "UniProt", "db_id": "P57753" }, { "db_name": "UniProt", "db_id": "P81559" }, { "db_name": "UniProt", "db_id": "Q29040" }, { "db_name": "UniProt", "db_id": "Q53AD2" }, { "db_name": "UniProt", "db_id": "Q91250" }, { "db_name": "UniProt", "db_id": "Q91424" }, { "db_name": "UniProt", "db_id": "Q9PVZ9" }, { "db_name": "UniProt", "db_id": "Q9QZJ5" }, { "db_name": "UniProt", "db_id": "Q9TV98" }, { "db_name": "UniProt", "db_id": "Q9YH33" }, { "db_name": "UniProt", "db_id": "Q9YHT3" }, { "db_name": "UniProt", "db_id": "Q9YHZ7" } ] }, { "id": "DS.d537.s0.e3", "type": "compound", "text": [ "tamoxifen" ], "offsets": [ [ 181, 190 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2733526" } ] } ]
[]
[]
[ { "id": "DS.d537.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d537.s0.e3", "arg2_id": "DS.d537.s0.e2", "normalized": [] }, { "id": "DS.d537.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d537.s0.e3", "arg2_id": "DS.d537.s0.e0", "normalized": [] }, { "id": "DS.d537.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d537.s0.e3", "arg2_id": "DS.d537.s0.e1", "normalized": [] } ]
DS.d538
18629637
[ { "id": "DS.d538.s0", "type": "", "text": [ "Fluorocitrate, an inhibitor of glial metabolism, inhibits the up-regulation of NOS expression, activity and NO production in the spinal cord induced by formalin test in rats." ], "offsets": [ [ 0, 174 ] ] }, { "id": "DS.d538.s1", "type": "", "text": [ "In order to explore the involvement of glia in the NO-mediated nociceptive transmission, the present study was undertaken to investigate the effect of fluorocitrate (FC), an inhibitor of glial metabolism, on NOS expression and activity and NO production in the spinal cord during the process of peripheral inflammatory pain and hyperalgesia induced by formalin test in rats." ], "offsets": [ [ 175, 549 ] ] } ]
[ { "id": "DS.d538.s0.e0", "type": "compound", "text": [ "Fluorocitrate" ], "offsets": [ [ 0, 13 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "107647" } ] }, { "id": "DS.d538.s0.e1", "type": "protein", "text": [ "NOS" ], "offsets": [ [ 79, 82 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O54705" }, { "db_name": "UniProt", "db_id": "O61309" }, { "db_name": "UniProt", "db_id": "O61608" }, { "db_name": "UniProt", "db_id": "Q26240" }, { "db_name": "UniProt", "db_id": "Q28969" }, { "db_name": "UniProt", "db_id": "Q9I9M2" } ] }, { "id": "DS.d538.s1.e0", "type": "compound", "text": [ "fluorocitrate" ], "offsets": [ [ 326, 339 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "107647" } ] }, { "id": "DS.d538.s1.e1", "type": "protein", "text": [ "NOS" ], "offsets": [ [ 383, 386 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O54705" }, { "db_name": "UniProt", "db_id": "O61309" }, { "db_name": "UniProt", "db_id": "O61608" }, { "db_name": "UniProt", "db_id": "Q26240" }, { "db_name": "UniProt", "db_id": "Q28969" }, { "db_name": "UniProt", "db_id": "Q9I9M2" } ] } ]
[]
[]
[ { "id": "DS.d538.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d538.s0.e0", "arg2_id": "DS.d538.s0.e1", "normalized": [] } ]
DS.d539
18629640
[ { "id": "DS.d539.s0", "type": "", "text": [ "Oral administration of morin remarkably prevented weight loss in the body and liver from DMN and inhibited the elevation of serum alanine transaminase (ALT), aspartate transaminase (AST), and total bilirubin levels." ], "offsets": [ [ 0, 215 ] ] } ]
[ { "id": "DS.d539.s0.e0", "type": "compound", "text": [ "morin" ], "offsets": [ [ 23, 28 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5281670" } ] }, { "id": "DS.d539.s0.e1", "type": "protein", "text": [ "AST" ], "offsets": [ [ 182, 185 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P0AE37" }, { "db_name": "UniProt", "db_id": "P0AE38" }, { "db_name": "UniProt", "db_id": "P80357" }, { "db_name": "UniProt", "db_id": "P80358" }, { "db_name": "UniProt", "db_id": "Q0TH83" }, { "db_name": "UniProt", "db_id": "Q1C8B0" }, { "db_name": "UniProt", "db_id": "Q1RB46" }, { "db_name": "UniProt", "db_id": "Q321N9" }, { "db_name": "UniProt", "db_id": "Q32G89" }, { "db_name": "UniProt", "db_id": "Q3Z294" }, { "db_name": "UniProt", "db_id": "Q5PHB9" }, { "db_name": "UniProt", "db_id": "Q66B20" }, { "db_name": "UniProt", "db_id": "Q7N2G8" }, { "db_name": "UniProt", "db_id": "Q83L52" }, { "db_name": "UniProt", "db_id": "Q8FH00" }, { "db_name": "UniProt", "db_id": "Q8Z6G0" }, { "db_name": "UniProt", "db_id": "Q8ZPV1" }, { "db_name": "UniProt", "db_id": "Q9NRA2" }, { "db_name": "UniProt", "db_id": "Q9ZC67" } ] }, { "id": "DS.d539.s0.e2", "type": "compound", "text": [ "bilirubin" ], "offsets": [ [ 198, 207 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5280352" } ] } ]
[]
[]
[ { "id": "DS.d539.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d539.s0.e0", "arg2_id": "DS.d539.s0.e1", "normalized": [] } ]
DS.d540
18631247
[ { "id": "DS.d540.s0", "type": "", "text": [ "Green tea extract reduces induction of p53 and apoptosis in UVB-irradiated human skin independent of transcriptional controls." ], "offsets": [ [ 0, 126 ] ] }, { "id": "DS.d540.s1", "type": "", "text": [ "We found that while OM24 treatment did not significantly affect UV-induced erythema and thymidine dimer formation, OM24 treatment significantly reduced UV-induced p53 expression in keratinocytes." ], "offsets": [ [ 127, 322 ] ] } ]
[ { "id": "DS.d540.s0.e0", "type": "compound", "text": [ "Green tea extract" ], "offsets": [ [ 0, 17 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "65064" } ] }, { "id": "DS.d540.s0.e1", "type": "protein", "text": [ "p53" ], "offsets": [ [ 39, 42 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O09185" }, { "db_name": "UniProt", "db_id": "O12946" }, { "db_name": "UniProt", "db_id": "O57538" }, { "db_name": "UniProt", "db_id": "O93379" }, { "db_name": "UniProt", "db_id": "P02340" }, { "db_name": "UniProt", "db_id": "P04637" }, { "db_name": "UniProt", "db_id": "P10361" }, { "db_name": "UniProt", "db_id": "P19558" }, { "db_name": "UniProt", "db_id": "P19559" }, { "db_name": "UniProt", "db_id": "P56423" }, { "db_name": "UniProt", "db_id": "P56424" }, { "db_name": "UniProt", "db_id": "P61260" }, { "db_name": "UniProt", "db_id": "P79820" }, { "db_name": "UniProt", "db_id": "P79892" }, { "db_name": "UniProt", "db_id": "Q29537" }, { "db_name": "UniProt", "db_id": "Q42578" }, { "db_name": "UniProt", "db_id": "Q8SPZ3" }, { "db_name": "UniProt", "db_id": "Q92143" }, { "db_name": "UniProt", "db_id": "Q9TTA1" }, { "db_name": "UniProt", "db_id": "Q9TUB2" }, { "db_name": "UniProt", "db_id": "Q9W678" }, { "db_name": "UniProt", "db_id": "Q9W679" } ] }, { "id": "DS.d540.s1.e0", "type": "compound", "text": [ "thymidine" ], "offsets": [ [ 215, 224 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5789" } ] }, { "id": "DS.d540.s1.e1", "type": "protein", "text": [ "p53" ], "offsets": [ [ 290, 293 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O09185" }, { "db_name": "UniProt", "db_id": "O12946" }, { "db_name": "UniProt", "db_id": "O57538" }, { "db_name": "UniProt", "db_id": "O93379" }, { "db_name": "UniProt", "db_id": "P02340" }, { "db_name": "UniProt", "db_id": "P04637" }, { "db_name": "UniProt", "db_id": "P10361" }, { "db_name": "UniProt", "db_id": "P19558" }, { "db_name": "UniProt", "db_id": "P19559" }, { "db_name": "UniProt", "db_id": "P56423" }, { "db_name": "UniProt", "db_id": "P56424" }, { "db_name": "UniProt", "db_id": "P61260" }, { "db_name": "UniProt", "db_id": "P79820" }, { "db_name": "UniProt", "db_id": "P79892" }, { "db_name": "UniProt", "db_id": "Q29537" }, { "db_name": "UniProt", "db_id": "Q42578" }, { "db_name": "UniProt", "db_id": "Q8SPZ3" }, { "db_name": "UniProt", "db_id": "Q92143" }, { "db_name": "UniProt", "db_id": "Q9TTA1" }, { "db_name": "UniProt", "db_id": "Q9TUB2" }, { "db_name": "UniProt", "db_id": "Q9W678" }, { "db_name": "UniProt", "db_id": "Q9W679" } ] } ]
[]
[]
[ { "id": "DS.d540.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d540.s0.e0", "arg2_id": "DS.d540.s0.e1", "normalized": [] } ]
DS.d542
18632742
[ { "id": "DS.d542.s0", "type": "", "text": [ "Here we show that NRG-1 selectively increases the power of kainate-induced, but not carbachol-induced, gamma oscillations in acute hippocampal slices." ], "offsets": [ [ 0, 150 ] ] }, { "id": "DS.d542.s1", "type": "", "text": [ "These effects of NRG-1beta are blocked by PD158780, a pan-specific antagonist of ErbB receptors, and are mediated specifically via ErbB4 receptors, because mice harboring a targeted mutation of ErbB4 do not respond to NRG-1." ], "offsets": [ [ 151, 375 ] ] } ]
[ { "id": "DS.d542.s0.e0", "type": "protein", "text": [ "NRG-1" ], "offsets": [ [ 18, 23 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q99988" }, { "db_name": "UniProt", "db_id": "Q9JKM5" } ] }, { "id": "DS.d542.s0.e1", "type": "compound", "text": [ "kainate" ], "offsets": [ [ 59, 66 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "10255" } ] }, { "id": "DS.d542.s0.e2", "type": "compound", "text": [ "carbachol" ], "offsets": [ [ 84, 93 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2551" } ] }, { "id": "DS.d542.s1.e0", "type": "compound", "text": [ "PD158780" ], "offsets": [ [ 193, 201 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "4707" } ] }, { "id": "DS.d542.s1.e1", "type": "protein", "text": [ "NRG-1" ], "offsets": [ [ 168, 173 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q99988" }, { "db_name": "UniProt", "db_id": "Q9JKM5" } ] } ]
[]
[]
[ { "id": "DS.d542.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d542.s0.e1", "arg2_id": "DS.d542.s0.e0", "normalized": [] }, { "id": "DS.d542.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d542.s1.e0", "arg2_id": "DS.d542.s1.e1", "normalized": [] } ]
DS.d543
18633436
[ { "id": "DS.d543.s0", "type": "", "text": [ "Of various agents tested in HaCaT cell cultures, only retinoic acid (10(-6) M) and staurosporine (2.5 x 10(-8) M) upregulated MMP-21 mRNA and protein expression, whereas tumor promoters, hormones, or dexamethasone were without effect." ], "offsets": [ [ 0, 234 ] ] } ]
[ { "id": "DS.d543.s0.e0", "type": "compound", "text": [ "retinoic acid" ], "offsets": [ [ 54, 67 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "444795" } ] }, { "id": "DS.d543.s0.e1", "type": "compound", "text": [ "staurosporine" ], "offsets": [ [ 83, 96 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5279" }, { "db_name": "PubChem", "db_id": "44259" }, { "db_name": "PubChem", "db_id": "451705" }, { "db_name": "PubChem", "db_id": "5311103" }, { "db_name": "PubChem", "db_id": "5459111" }, { "db_name": "PubChem", "db_id": "6419748" }, { "db_name": "PubChem", "db_id": "6711321" }, { "db_name": "PubChem", "db_id": "9956178" }, { "db_name": "PubChem", "db_id": "44299148" } ] }, { "id": "DS.d543.s0.e2", "type": "protein", "text": [ "MMP-21" ], "offsets": [ [ 126, 132 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O75900" }, { "db_name": "UniProt", "db_id": "O93470" }, { "db_name": "UniProt", "db_id": "Q8K3F2" }, { "db_name": "UniProt", "db_id": "Q8N119" }, { "db_name": "UniProt", "db_id": "Q90YC2" }, { "db_name": "UniProt", "db_id": "Q9R0S2" } ] }, { "id": "DS.d543.s0.e3", "type": "compound", "text": [ "dexamethasone" ], "offsets": [ [ 200, 213 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5743" } ] } ]
[]
[]
[ { "id": "DS.d543.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d543.s0.e0", "arg2_id": "DS.d543.s0.e2", "normalized": [] }, { "id": "DS.d543.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d543.s0.e1", "arg2_id": "DS.d543.s0.e2", "normalized": [] } ]
DS.d544
18633446
[ { "id": "DS.d544.s0", "type": "", "text": [ "We have generated two novel chimeric VEGF-binding molecules, sFLT01 and sFLT02, which consist of the second immunoglobulin (IgG)-like domain of Flt-1 fused either to a human IgG1 Fc or solely to the CH3 domain of IgG1 Fc through a polyglycine linker 9Gly." ], "offsets": [ [ 0, 255 ] ] } ]
[ { "id": "DS.d544.s0.e0", "type": "protein", "text": [ "VEGF" ], "offsets": [ [ 37, 41 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P15691" }, { "db_name": "UniProt", "db_id": "P15692" }, { "db_name": "UniProt", "db_id": "P26617" }, { "db_name": "UniProt", "db_id": "P49151" }, { "db_name": "UniProt", "db_id": "P50412" }, { "db_name": "UniProt", "db_id": "P67964" }, { "db_name": "UniProt", "db_id": "P67965" }, { "db_name": "UniProt", "db_id": "Q99PS1" }, { "db_name": "UniProt", "db_id": "Q9GKR0" }, { "db_name": "UniProt", "db_id": "Q9MYV3" } ] }, { "id": "DS.d544.s0.e1", "type": "protein", "text": [ "Flt-1" ], "offsets": [ [ 144, 149 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P17948" }, { "db_name": "UniProt", "db_id": "P53767" } ] }, { "id": "DS.d544.s0.e3", "type": "compound", "text": [ "polyglycine" ], "offsets": [ [ 231, 242 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "750" } ] } ]
[]
[]
[ { "id": "DS.d544.s0.i3", "type": "compound-protein-interaction", "arg1_id": "DS.d544.s0.e3", "arg2_id": "DS.d544.s0.e1", "normalized": [] } ]
DS.d545
18633600
[ { "id": "DS.d545.s0", "type": "", "text": [ "By contrast, treatment of N2a cells with 1-10 microM DZO resulted in marked reductions in the expression of the axon growth-associated protein GAP-43." ], "offsets": [ [ 0, 150 ] ] }, { "id": "DS.d545.s1", "type": "", "text": [ "DZO-treated cells also showed an increased expression of the heat shock protein HSP-70 compared to controls." ], "offsets": [ [ 151, 259 ] ] } ]
[ { "id": "DS.d545.s0.e0", "type": "compound", "text": [ "DZO" ], "offsets": [ [ 53, 56 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6419789" } ] }, { "id": "DS.d545.s0.e1", "type": "protein", "text": [ "GAP" ], "offsets": [ [ 143, 146 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P09851" }, { "db_name": "UniProt", "db_id": "P20936" }, { "db_name": "UniProt", "db_id": "P50904" }, { "db_name": "UniProt", "db_id": "P74851" }, { "db_name": "UniProt", "db_id": "P74873" }, { "db_name": "UniProt", "db_id": "Q5PEA9" }, { "db_name": "UniProt", "db_id": "Q92211" }, { "db_name": "UniProt", "db_id": "Q92263" } ] }, { "id": "DS.d545.s1.e0", "type": "compound", "text": [ "DZO" ], "offsets": [ [ 151, 154 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6419789" } ] }, { "id": "DS.d545.s1.e1", "type": "protein", "text": [ "HSP-70" ], "offsets": [ [ 231, 237 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P27894" } ] } ]
[]
[]
[ { "id": "DS.d545.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d545.s0.e0", "arg2_id": "DS.d545.s0.e1", "normalized": [] }, { "id": "DS.d545.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d545.s1.e0", "arg2_id": "DS.d545.s1.e1", "normalized": [] } ]
DS.d547
18633701
[ { "id": "DS.d547.s0", "type": "", "text": [ "We showed that in comparison to stage VI, stages I-V oocytes expressed higher levels of O-GlcNAc correlating changes in OGT expression, but not in UDP-GlcNAc pools." ], "offsets": [ [ 0, 164 ] ] }, { "id": "DS.d547.s1", "type": "", "text": [ "Upon progesterone stimulation, an O-GlcNAc level burst occurred during meiotic resumption long before MPF and Mos-Erk2 pathways activations." ], "offsets": [ [ 165, 305 ] ] } ]
[ { "id": "DS.d547.s0.e0", "type": "protein", "text": [ "O-GlcNAc" ], "offsets": [ [ 88, 96 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O18158" } ] }, { "id": "DS.d547.s0.e1", "type": "protein", "text": [ "OGT" ], "offsets": [ [ 120, 123 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O15294" }, { "db_name": "UniProt", "db_id": "O18158" }, { "db_name": "UniProt", "db_id": "P81436" } ] }, { "id": "DS.d547.s0.e2", "type": "compound", "text": [ "UDP-GlcNAc" ], "offsets": [ [ 147, 157 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "445675" }, { "db_name": "PubChem", "db_id": "643981" }, { "db_name": "PubChem", "db_id": "9547196" } ] }, { "id": "DS.d547.s1.e0", "type": "compound", "text": [ "progesterone" ], "offsets": [ [ 170, 182 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5994" } ] }, { "id": "DS.d547.s1.e1", "type": "protein", "text": [ "O-GlcNAc" ], "offsets": [ [ 199, 207 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O18158" } ] }, { "id": "DS.d547.s1.e2", "type": "protein", "text": [ "MPF" ], "offsets": [ [ 267, 270 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q13421" }, { "db_name": "UniProt", "db_id": "Q61468" }, { "db_name": "UniProt", "db_id": "Q9ERA7" } ] }, { "id": "DS.d547.s1.e3", "type": "protein", "text": [ "Mos" ], "offsets": [ [ 275, 278 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P00536" }, { "db_name": "UniProt", "db_id": "P00539" }, { "db_name": "UniProt", "db_id": "P12965" } ] }, { "id": "DS.d547.s1.e4", "type": "protein", "text": [ "Erk2" ], "offsets": [ [ 279, 283 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P63085" }, { "db_name": "UniProt", "db_id": "P63086" } ] } ]
[]
[]
[ { "id": "DS.d547.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d547.s1.e0", "arg2_id": "DS.d547.s1.e2", "normalized": [] }, { "id": "DS.d547.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d547.s1.e0", "arg2_id": "DS.d547.s1.e3", "normalized": [] }, { "id": "DS.d547.s1.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d547.s1.e0", "arg2_id": "DS.d547.s1.e4", "normalized": [] }, { "id": "DS.d547.s1.i3", "type": "compound-protein-interaction", "arg1_id": "DS.d547.s1.e0", "arg2_id": "DS.d547.s1.e1", "normalized": [] } ]
DS.d548
18633707
[ { "id": "DS.d548.s0", "type": "", "text": [ "Mean plasma levels of folic acid, homocysteine, and vitamin B12 did not change, but there was a significant decrease of CRP at T1, 0.36 mg dl(-1) on average (P = 0.01), which was maintained at T2." ], "offsets": [ [ 0, 196 ] ] } ]
[ { "id": "DS.d548.s0.e0", "type": "compound", "text": [ "folic acid" ], "offsets": [ [ 22, 32 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6037" } ] }, { "id": "DS.d548.s0.e1", "type": "compound", "text": [ "homocysteine" ], "offsets": [ [ 34, 46 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "778" } ] }, { "id": "DS.d548.s0.e2", "type": "protein", "text": [ "CRP" ], "offsets": [ [ 120, 123 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O19062" }, { "db_name": "UniProt", "db_id": "P02741" }, { "db_name": "UniProt", "db_id": "P02742" }, { "db_name": "UniProt", "db_id": "P08462" }, { "db_name": "UniProt", "db_id": "P18151" }, { "db_name": "UniProt", "db_id": "P21291" }, { "db_name": "UniProt", "db_id": "P41964" }, { "db_name": "UniProt", "db_id": "P47875" }, { "db_name": "UniProt", "db_id": "P49254" }, { "db_name": "UniProt", "db_id": "P49262" }, { "db_name": "UniProt", "db_id": "P52753" }, { "db_name": "UniProt", "db_id": "P67966" }, { "db_name": "UniProt", "db_id": "P67967" }, { "db_name": "UniProt", "db_id": "P97315" }, { "db_name": "UniProt", "db_id": "Q07203" } ] } ]
[]
[]
[]
DS.d549
18634065
[ { "id": "DS.d549.s0", "type": "", "text": [ "Chondrocytes grown in monolayer were treated with interleukin-1alpha (IL-1alpha), insulin-like growth factor-I (IGF-I), C3 Transferase, Y27632, or transfected with Rho wild type or two constitutively active mutants of Rho (Q63L and G14V)." ], "offsets": [ [ 0, 238 ] ] }, { "id": "DS.d549.s1", "type": "", "text": [ "Affinity assays were performed to measure endogenous GTP-bound Rho, and confocal microscopy was used to assess changes in organization of the actin cytoskeleton." ], "offsets": [ [ 239, 400 ] ] }, { "id": "DS.d549.s2", "type": "", "text": [ "IL-1alpha and RhoG14V increased cytoplasmic actin stress fiber formation, which was blocked by C3 Transferase, and Y27632." ], "offsets": [ [ 401, 523 ] ] }, { "id": "DS.d549.s3", "type": "", "text": [ "Expression of RhoQ63L or RhoG14V resulted in increased MMP-13 expression; however, inhibition of Rho with Y27632 was unable to inhibit IL-1alpha-induced MMP-13 expression." ], "offsets": [ [ 524, 695 ] ] } ]
[ { "id": "DS.d549.s0.e0", "type": "protein", "text": [ "IL-1alpha" ], "offsets": [ [ 70, 79 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O46612" }, { "db_name": "UniProt", "db_id": "O46613" }, { "db_name": "UniProt", "db_id": "P01582" }, { "db_name": "UniProt", "db_id": "P01583" }, { "db_name": "UniProt", "db_id": "P04822" }, { "db_name": "UniProt", "db_id": "P08831" }, { "db_name": "UniProt", "db_id": "P16598" }, { "db_name": "UniProt", "db_id": "P18430" }, { "db_name": "UniProt", "db_id": "P46647" }, { "db_name": "UniProt", "db_id": "P48089" }, { "db_name": "UniProt", "db_id": "P79161" }, { "db_name": "UniProt", "db_id": "P79340" }, { "db_name": "UniProt", "db_id": "Q28385" }, { "db_name": "UniProt", "db_id": "Q28579" }, { "db_name": "UniProt", "db_id": "Q3HWU1" }, { "db_name": "UniProt", "db_id": "Q60480" }, { "db_name": "UniProt", "db_id": "Q865X7" } ] }, { "id": "DS.d549.s0.e1", "type": "protein", "text": [ "insulin" ], "offsets": [ [ 82, 89 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01314" }, { "db_name": "UniProt", "db_id": "P01316" }, { "db_name": "UniProt", "db_id": "P01319" }, { "db_name": "UniProt", "db_id": "P01320" }, { "db_name": "UniProt", "db_id": "P01324" }, { "db_name": "UniProt", "db_id": "P01328" }, { "db_name": "UniProt", "db_id": "P01330" }, { "db_name": "UniProt", "db_id": "P01331" }, { "db_name": "UniProt", "db_id": "P01334" }, { "db_name": "UniProt", "db_id": "P01336" }, { "db_name": "UniProt", "db_id": "P01340" }, { "db_name": "UniProt", "db_id": "P07453" }, { "db_name": "UniProt", "db_id": "P09476" }, { "db_name": "UniProt", "db_id": "P09477" }, { "db_name": "UniProt", "db_id": "P0C236" }, { "db_name": "UniProt", "db_id": "P12703" }, { "db_name": "UniProt", "db_id": "P12704" }, { "db_name": "UniProt", "db_id": "P12708" }, { "db_name": "UniProt", "db_id": "P13190" }, { "db_name": "UniProt", "db_id": "P18109" }, { "db_name": "UniProt", "db_id": "P29335" }, { "db_name": "UniProt", "db_id": "P42633" }, { "db_name": "UniProt", "db_id": "P67968" }, { "db_name": "UniProt", "db_id": "P67969" }, { "db_name": "UniProt", "db_id": "P67971" }, { "db_name": "UniProt", "db_id": "P67973" }, { "db_name": "UniProt", "db_id": "P67974" }, { "db_name": "UniProt", "db_id": "P68243" }, { "db_name": "UniProt", "db_id": "P68245" }, { "db_name": "UniProt", "db_id": "P68987" }, { "db_name": "UniProt", "db_id": "P68988" }, { "db_name": "UniProt", "db_id": "P68989" }, { "db_name": "UniProt", "db_id": "P68990" }, { "db_name": "UniProt", "db_id": "P68991" }, { "db_name": "UniProt", "db_id": "P68992" }, { "db_name": "UniProt", "db_id": "P69046" }, { "db_name": "UniProt", "db_id": "P69047" }, { "db_name": "UniProt", "db_id": "P69048" }, { "db_name": "UniProt", "db_id": "P81423" }, { "db_name": "UniProt", "db_id": "P81881" }, { "db_name": "UniProt", "db_id": "Q9TQY7" } ] }, { "id": "DS.d549.s0.e2", "type": "protein", "text": [ "IGF-I" ], "offsets": [ [ 112, 117 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P05017" }, { "db_name": "UniProt", "db_id": "P07455" }, { "db_name": "UniProt", "db_id": "P08025" }, { "db_name": "UniProt", "db_id": "P10763" }, { "db_name": "UniProt", "db_id": "P16545" }, { "db_name": "UniProt", "db_id": "P17085" }, { "db_name": "UniProt", "db_id": "P17647" }, { "db_name": "UniProt", "db_id": "P18254" }, { "db_name": "UniProt", "db_id": "P33712" }, { "db_name": "UniProt", "db_id": "P51457" }, { "db_name": "UniProt", "db_id": "P51458" }, { "db_name": "UniProt", "db_id": "P51462" }, { "db_name": "UniProt", "db_id": "Q02815" }, { "db_name": "UniProt", "db_id": "Q28933" }, { "db_name": "UniProt", "db_id": "Q68LC0" }, { "db_name": "UniProt", "db_id": "Q6GUL6" }, { "db_name": "UniProt", "db_id": "Q6IVA5" }, { "db_name": "UniProt", "db_id": "Q6JLX1" }, { "db_name": "UniProt", "db_id": "Q95222" } ] }, { "id": "DS.d549.s0.e3", "type": "compound", "text": [ "Y27632" ], "offsets": [ [ 136, 142 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "448042" } ] }, { "id": "DS.d549.s1.e0", "type": "compound", "text": [ "GTP" ], "offsets": [ [ 292, 295 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6830" } ] }, { "id": "DS.d549.s1.e1", "type": "protein", "text": [ "Rho" ], "offsets": [ [ 302, 305 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O51891" }, { "db_name": "UniProt", "db_id": "O67031" }, { "db_name": "UniProt", "db_id": "O83281" }, { "db_name": "UniProt", "db_id": "P03304" }, { "db_name": "UniProt", "db_id": "P0A295" }, { "db_name": "UniProt", "db_id": "P0A296" }, { "db_name": "UniProt", "db_id": "P0AG30" }, { "db_name": "UniProt", "db_id": "P0AG31" }, { "db_name": "UniProt", "db_id": "P0AG32" }, { "db_name": "UniProt", "db_id": "P0AG33" }, { "db_name": "UniProt", "db_id": "P15409" }, { "db_name": "UniProt", "db_id": "P17593" }, { "db_name": "UniProt", "db_id": "P17594" }, { "db_name": "UniProt", "db_id": "P20350" }, { "db_name": "UniProt", "db_id": "P29403" }, { "db_name": "UniProt", "db_id": "P33561" }, { "db_name": "UniProt", "db_id": "P35359" 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[ { "db_name": "PubChem", "db_id": "448042" } ] }, { "id": "DS.d549.s3.e3", "type": "protein", "text": [ "IL-1alpha" ], "offsets": [ [ 659, 668 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O46612" }, { "db_name": "UniProt", "db_id": "O46613" }, { "db_name": "UniProt", "db_id": "P01582" }, { "db_name": "UniProt", "db_id": "P01583" }, { "db_name": "UniProt", "db_id": "P04822" }, { "db_name": "UniProt", "db_id": "P08831" }, { "db_name": "UniProt", "db_id": "P16598" }, { "db_name": "UniProt", "db_id": "P18430" }, { "db_name": "UniProt", "db_id": "P46647" }, { "db_name": "UniProt", "db_id": "P48089" }, { "db_name": "UniProt", "db_id": "P79161" }, { "db_name": "UniProt", "db_id": "P79340" }, { "db_name": "UniProt", "db_id": "Q28385" }, { "db_name": "UniProt", "db_id": "Q28579" }, { "db_name": "UniProt", "db_id": "Q3HWU1" }, { "db_name": "UniProt", "db_id": "Q60480" }, { "db_name": "UniProt", "db_id": "Q865X7" } ] }, { "id": "DS.d549.s3.e4", "type": "protein", "text": [ "MMP-13" ], "offsets": [ [ 677, 683 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O18927" }, { "db_name": "UniProt", "db_id": "O62806" }, { "db_name": "UniProt", "db_id": "O77656" }, { "db_name": "UniProt", "db_id": "P23097" }, { "db_name": "UniProt", "db_id": "P33435" }, { "db_name": "UniProt", "db_id": "P45452" }, { "db_name": "UniProt", "db_id": "Q10835" } ] } ]
[]
[]
[ { "id": "DS.d549.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d549.s1.e0", "arg2_id": "DS.d549.s1.e1", "normalized": [] }, { "id": "DS.d549.s2.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d549.s2.e2", "arg2_id": "DS.d549.s2.e1", "normalized": [] }, { "id": "DS.d549.s2.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d549.s2.e2", "arg2_id": "DS.d549.s2.e0", "normalized": [] }, { "id": "DS.d549.s3.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d549.s3.e2", "arg2_id": "DS.d549.s3.e1", "normalized": [] } ]
DS.d550
18634706
[ { "id": "DS.d550.s0", "type": "", "text": [ "Plasma total cholesterol, TAG, HDL, HDL2, HDL3, LDL, C-reactive protein, IL-6, IL-18, intercellular adhesion molecule-1, oxidised LDL, oxygen radical absorbance capacity using perchloric acid (ORACPCA), whole-blood fatty acids, bleeding time and blood pressure were measured at the beginning and end of each dietary period." ], "offsets": [ [ 0, 323 ] ] } ]
[ { "id": "DS.d550.s0.e0", "type": "compound", "text": [ "cholesterol" ], "offsets": [ [ 13, 24 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "304" }, { "db_name": "PubChem", "db_id": "5997" }, { "db_name": "PubChem", "db_id": "6432564" }, { "db_name": "PubChem", "db_id": "11025495" } ] }, { "id": "DS.d550.s0.e1", "type": "protein", "text": [ "TAG" ], "offsets": [ [ 26, 29 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P44321" } ] }, { "id": "DS.d550.s0.e2", "type": "protein", "text": [ "IL-6" ], "offsets": [ [ 73, 77 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O35736" }, { "db_name": "UniProt", "db_id": "P05231" }, { "db_name": "UniProt", "db_id": "P08505" }, { "db_name": "UniProt", "db_id": "P20607" }, { "db_name": "UniProt", "db_id": "P26892" }, { "db_name": "UniProt", "db_id": "P26893" }, { "db_name": "UniProt", "db_id": "P29455" }, { "db_name": "UniProt", "db_id": "P41323" }, { "db_name": "UniProt", "db_id": "P41683" }, { "db_name": "UniProt", "db_id": "P41693" }, { "db_name": "UniProt", "db_id": "P46650" }, { "db_name": "UniProt", "db_id": "P51494" }, { "db_name": "UniProt", "db_id": "P79341" }, { "db_name": "UniProt", "db_id": "Q25BC2" }, { "db_name": "UniProt", "db_id": "Q28319" }, { "db_name": "UniProt", "db_id": "Q28747" }, { "db_name": "UniProt", "db_id": "Q28819" }, { "db_name": "UniProt", "db_id": "Q2MH06" }, { "db_name": "UniProt", "db_id": "Q5I6E3" }, { "db_name": "UniProt", "db_id": "Q6V919" }, { "db_name": "UniProt", "db_id": "Q865W7" }, { "db_name": "UniProt", "db_id": "Q865X6" }, { "db_name": "UniProt", "db_id": "Q8MKH0" }, { "db_name": "UniProt", "db_id": "Q95181" }, { "db_name": "UniProt", "db_id": "Q9MZR1" }, { "db_name": "UniProt", "db_id": "Q9XT80" } ] }, { "id": "DS.d550.s0.e3", "type": "protein", "text": [ "IL-18" ], "offsets": [ [ 79, 84 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O19073" }, { "db_name": "UniProt", "db_id": "P70380" }, { "db_name": "UniProt", "db_id": "P97636" }, { "db_name": "UniProt", "db_id": "Q14116" }, { "db_name": "UniProt", "db_id": "Q3ZT29" }, { "db_name": "UniProt", "db_id": "Q5I931" }, { "db_name": "UniProt", "db_id": "Q8QFQ8" }, { "db_name": "UniProt", "db_id": "Q95M33" }, { "db_name": "UniProt", "db_id": "Q9TU73" }, { "db_name": "UniProt", "db_id": "Q9XSQ7" }, { "db_name": "UniProt", "db_id": "Q9XSR0" } ] }, { "id": "DS.d550.s0.e4", "type": "compound", "text": [ "oxygen" ], "offsets": [ [ 135, 141 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "977" } ] }, { "id": "DS.d550.s0.e5", "type": "compound", "text": [ "perchloric acid" ], "offsets": [ [ 176, 191 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "24247" } ] } ]
[]
[]
[]
DS.d551
18634843
[ { "id": "DS.d551.s0", "type": "", "text": [ "The increase of mature IL-18 by macrophages was inhibited by caspase-1 inhibitor : caspase-1 is known to cleave the proform of IL-18 to produce active mature IL-18." ], "offsets": [ [ 0, 164 ] ] } ]
[ { "id": "DS.d551.s0.e0", "type": "protein", "text": [ "IL-18" ], "offsets": [ [ 23, 28 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O19073" }, { "db_name": "UniProt", "db_id": "P70380" }, { "db_name": "UniProt", "db_id": "P97636" }, { "db_name": "UniProt", "db_id": "Q14116" }, { "db_name": "UniProt", "db_id": "Q3ZT29" }, { "db_name": "UniProt", "db_id": "Q5I931" }, { "db_name": "UniProt", "db_id": "Q8QFQ8" }, { "db_name": "UniProt", "db_id": "Q95M33" }, { "db_name": "UniProt", "db_id": "Q9TU73" }, { "db_name": "UniProt", "db_id": "Q9XSQ7" }, { "db_name": "UniProt", "db_id": "Q9XSR0" } ] }, { "id": "DS.d551.s0.e1", "type": "compound", "text": [ "caspase-1 inhibitor" ], "offsets": [ [ 61, 80 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "44134608" } ] }, { "id": "DS.d551.s0.e2", "type": "protein", "text": [ "IL-18" ], "offsets": [ [ 127, 132 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O19073" }, { "db_name": "UniProt", "db_id": "P70380" }, { "db_name": "UniProt", "db_id": "P97636" }, { "db_name": "UniProt", "db_id": "Q14116" }, { "db_name": "UniProt", "db_id": "Q3ZT29" }, { "db_name": "UniProt", "db_id": "Q5I931" }, { "db_name": "UniProt", "db_id": "Q8QFQ8" }, { "db_name": "UniProt", "db_id": "Q95M33" }, { "db_name": "UniProt", "db_id": "Q9TU73" }, { "db_name": "UniProt", "db_id": "Q9XSQ7" }, { "db_name": "UniProt", "db_id": "Q9XSR0" } ] }, { "id": "DS.d551.s0.e3", "type": "protein", "text": [ "IL-18" ], "offsets": [ [ 127, 132 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O19073" }, { "db_name": "UniProt", "db_id": "P70380" }, { "db_name": "UniProt", "db_id": "P97636" }, { "db_name": "UniProt", "db_id": "Q14116" }, { "db_name": "UniProt", "db_id": "Q3ZT29" }, { "db_name": "UniProt", "db_id": "Q5I931" }, { "db_name": "UniProt", "db_id": "Q8QFQ8" }, { "db_name": "UniProt", "db_id": "Q95M33" }, { "db_name": "UniProt", "db_id": "Q9TU73" }, { "db_name": "UniProt", "db_id": "Q9XSQ7" }, { "db_name": "UniProt", "db_id": "Q9XSR0" } ] } ]
[]
[]
[ { "id": "DS.d551.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d551.s0.e1", "arg2_id": "DS.d551.s0.e0", "normalized": [] } ]
DS.d552
18635261
[ { "id": "DS.d552.s0", "type": "", "text": [ "In absence of stretch, we could activate Gns and deactivate GK1 by 1-oleoyl-2-acetyl-sn-glycerol (OAG) and other amphipaths." ], "offsets": [ [ 0, 124 ] ] } ]
[ { "id": "DS.d552.s0.e0", "type": "protein", "text": [ "Gns" ], "offsets": [ [ 41, 44 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P64267" }, { "db_name": "UniProt", "db_id": "P64268" } ] }, { "id": "DS.d552.s0.e1", "type": "protein", "text": [ "GK1" ], "offsets": [ [ 60, 63 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q9GTW9" } ] }, { "id": "DS.d552.s0.e2", "type": "compound", "text": [ "1-oleoyl-2-acetyl-sn-glycerol" ], "offsets": [ [ 67, 96 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1394" }, { "db_name": "PubChem", "db_id": "5353264" }, { "db_name": "PubChem", "db_id": "6437055" } ] }, { "id": "DS.d552.s0.e3", "type": "compound", "text": [ "OAG" ], "offsets": [ [ 98, 101 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5353264" } ] } ]
[]
[]
[ { "id": "DS.d552.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d552.s0.e3", "arg2_id": "DS.d552.s0.e0", "normalized": [] }, { "id": "DS.d552.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d552.s0.e2", "arg2_id": "DS.d552.s0.e0", "normalized": [] }, { "id": "DS.d552.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d552.s0.e2", "arg2_id": "DS.d552.s0.e1", "normalized": [] }, { "id": "DS.d552.s0.i3", "type": "compound-protein-interaction", "arg1_id": "DS.d552.s0.e3", "arg2_id": "DS.d552.s0.e1", "normalized": [] } ]
DS.d553
18635336
[ { "id": "DS.d553.s0", "type": "", "text": [ "Using enzyme-linked immunosorbent assays, we showed DHMEQ to inhibit LPS-induced secretion of IL-6 and TNF-alpha." ], "offsets": [ [ 0, 113 ] ] } ]
[ { "id": "DS.d553.s0.e0", "type": "compound", "text": [ "DHMEQ" ], "offsets": [ [ 52, 57 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "9881652" } ] }, { "id": "DS.d553.s0.e1", "type": "protein", "text": [ "IL-6" ], "offsets": [ [ 94, 98 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O35736" }, { "db_name": "UniProt", "db_id": "P05231" }, { "db_name": "UniProt", "db_id": "P08505" }, { "db_name": "UniProt", "db_id": "P20607" }, { "db_name": "UniProt", "db_id": "P26892" }, { "db_name": "UniProt", "db_id": "P26893" }, { "db_name": "UniProt", "db_id": "P29455" }, { "db_name": "UniProt", "db_id": "P41323" }, { "db_name": "UniProt", "db_id": "P41683" }, { "db_name": "UniProt", "db_id": "P41693" }, { "db_name": "UniProt", "db_id": "P46650" }, { "db_name": "UniProt", "db_id": "P51494" }, { "db_name": "UniProt", "db_id": "P79341" }, { "db_name": "UniProt", "db_id": "Q25BC2" }, { "db_name": "UniProt", "db_id": "Q28319" }, { "db_name": "UniProt", "db_id": "Q28747" }, { "db_name": "UniProt", "db_id": "Q28819" }, { "db_name": "UniProt", "db_id": "Q2MH06" }, { "db_name": "UniProt", "db_id": "Q5I6E3" }, { "db_name": "UniProt", "db_id": "Q6V919" }, { "db_name": "UniProt", "db_id": "Q865W7" }, { "db_name": "UniProt", "db_id": "Q865X6" }, { "db_name": "UniProt", "db_id": "Q8MKH0" }, { "db_name": "UniProt", "db_id": "Q95181" }, { "db_name": "UniProt", "db_id": "Q9MZR1" }, { "db_name": "UniProt", "db_id": "Q9XT80" } ] }, { "id": "DS.d553.s0.e2", "type": "protein", "text": [ "TNF-alpha" ], "offsets": [ [ 103, 112 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O35734" }, { "db_name": "UniProt", "db_id": "O77510" }, { "db_name": "UniProt", "db_id": "O77764" }, { "db_name": "UniProt", "db_id": "P01375" }, { "db_name": "UniProt", "db_id": "P04924" }, { "db_name": "UniProt", "db_id": "P06804" }, { "db_name": "UniProt", "db_id": "P13296" }, { "db_name": "UniProt", "db_id": "P16599" }, { "db_name": "UniProt", "db_id": "P19101" }, { "db_name": "UniProt", "db_id": "P23383" }, { "db_name": "UniProt", "db_id": "P23563" }, { "db_name": "UniProt", "db_id": "P29553" }, { "db_name": "UniProt", "db_id": "P33620" }, { "db_name": "UniProt", "db_id": "P36939" }, { "db_name": "UniProt", "db_id": "P48094" }, { "db_name": "UniProt", "db_id": "P51435" }, { "db_name": "UniProt", "db_id": "P51742" }, { "db_name": "UniProt", "db_id": "P51743" }, { "db_name": "UniProt", "db_id": "P59684" }, { "db_name": "UniProt", "db_id": "P59693" }, { "db_name": "UniProt", "db_id": "P59694" }, { "db_name": "UniProt", "db_id": "P59695" }, { "db_name": "UniProt", "db_id": "P79337" }, { "db_name": "UniProt", "db_id": "P79374" }, { "db_name": "UniProt", "db_id": "Q06599" }, { "db_name": "UniProt", "db_id": "Q19LH4" }, { "db_name": "UniProt", "db_id": "Q1G1A2" }, { "db_name": "UniProt", "db_id": "Q1WM27" }, { "db_name": "UniProt", "db_id": "Q2MH05" }, { "db_name": "UniProt", "db_id": "Q539C2" }, { "db_name": "UniProt", "db_id": "Q75N23" }, { "db_name": "UniProt", "db_id": "Q8HZD9" }, { "db_name": "UniProt", "db_id": "Q8JFG3" }, { "db_name": "UniProt", "db_id": "Q8MKG8" }, { "db_name": "UniProt", "db_id": "Q8WNR1" }, { "db_name": "UniProt", "db_id": "Q9BEA1" } ] } ]
[]
[]
[ { "id": "DS.d553.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d553.s0.e0", "arg2_id": "DS.d553.s0.e1", "normalized": [] }, { "id": "DS.d553.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d553.s0.e0", "arg2_id": "DS.d553.s0.e2", "normalized": [] } ]
DS.d554
18635390
[ { "id": "DS.d554.s0", "type": "", "text": [ "The inhibition of DMBA-carcinogenesis by GLN application was associated with increased arterial GLN and GSH, elevated buccal mucosa GSH as well as induction of bax and PARP, and inhibition of bcl-2." ], "offsets": [ [ 0, 198 ] ] } ]
[ { "id": "DS.d554.s0.e0", "type": "compound", "text": [ "GSH" ], "offsets": [ [ 104, 107 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "124886" } ] }, { "id": "DS.d554.s0.e1", "type": "compound", "text": [ "GSH" ], "offsets": [ [ 132, 135 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "124886" } ] }, { "id": "DS.d554.s0.e2", "type": "protein", "text": [ "bax" ], "offsets": [ [ 160, 163 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P27297" }, { "db_name": "UniProt", "db_id": "Q07813" }, { "db_name": "UniProt", "db_id": "Q63690" } ] }, { "id": "DS.d554.s0.e3", "type": "protein", "text": [ "PARP" ], "offsets": [ [ 168, 172 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O50017" }, { "db_name": "UniProt", "db_id": "P08469" }, { "db_name": "UniProt", "db_id": "P14043" }, { "db_name": "UniProt", "db_id": "P31669" }, { "db_name": "UniProt", "db_id": "P35875" }, { "db_name": "UniProt", "db_id": "P55057" }, { "db_name": "UniProt", "db_id": "Q08824" }, { "db_name": "UniProt", "db_id": "Q11208" } ] }, { "id": "DS.d554.s0.e4", "type": "protein", "text": [ "bcl-2" ], "offsets": [ [ 192, 197 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P10417" }, { "db_name": "UniProt", "db_id": "P49950" } ] } ]
[]
[]
[]
DS.d555
18635693
[ { "id": "DS.d555.s0", "type": "", "text": [ "Dopamine release and direct stimulation of dopamine D2 and serotonin 5-HT2A receptors also contributes to the overall action of MDMA." ], "offsets": [ [ 0, 133 ] ] }, { "id": "DS.d555.s1", "type": "", "text": [ "Our findings suggest that MDMA differentially affects higher cognitive functions, but does not support the hypothesis from animal studies, that some of the MDMA effects are causally mediated through action at the 5-HT1A receptor system." ], "offsets": [ [ 134, 370 ] ] } ]
[ { "id": "DS.d555.s0.e0", "type": "protein", "text": [ "5-HT2A" ], "offsets": [ [ 69, 75 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P50129" } ] }, { "id": "DS.d555.s0.e1", "type": "compound", "text": [ "MDMA" ], "offsets": [ [ 128, 132 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1615" } ] }, { "id": "DS.d555.s1.e0", "type": "compound", "text": [ "MDMA" ], "offsets": [ [ 160, 164 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1615" } ] }, { "id": "DS.d555.s1.e1", "type": "compound", "text": [ "MDMA" ], "offsets": [ [ 290, 294 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1615" } ] }, { "id": "DS.d555.s1.e2", "type": "protein", "text": [ "5-HT1A" ], "offsets": [ [ 347, 353 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P08908" }, { "db_name": "UniProt", "db_id": "P19327" }, { "db_name": "UniProt", "db_id": "P28285" }, { "db_name": "UniProt", "db_id": "Q64264" }, { "db_name": "UniProt", "db_id": "Q6XXX9" }, { "db_name": "UniProt", "db_id": "Q6XXY0" }, { "db_name": "UniProt", "db_id": "Q98998" }, { "db_name": "UniProt", "db_id": "Q9N296" }, { "db_name": "UniProt", "db_id": "Q9N297" }, { "db_name": "UniProt", "db_id": "Q9N298" } ] } ]
[]
[]
[ { "id": "DS.d555.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d555.s0.e1", "arg2_id": "DS.d555.s0.e0", "normalized": [] } ]
DS.d556
18635704
[ { "id": "DS.d556.s0", "type": "", "text": [ "These results suggest that AKT1 does not play a significant role in clinical and functional manifestations in patients with schizophrenia who receive risperidone treatment." ], "offsets": [ [ 0, 172 ] ] } ]
[ { "id": "DS.d556.s0.e0", "type": "protein", "text": [ "AKT1" ], "offsets": [ [ 27, 31 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P31749" }, { "db_name": "UniProt", "db_id": "Q01314" }, { "db_name": "UniProt", "db_id": "Q38998" }, { "db_name": "UniProt", "db_id": "Q8VYX2" } ] }, { "id": "DS.d556.s0.e1", "type": "compound", "text": [ "risperidone" ], "offsets": [ [ 150, 161 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5073" } ] } ]
[]
[]
[]
DS.d557
18635814
[ { "id": "DS.d557.s0", "type": "", "text": [ "Urethane is a chemical carcinogen found in tobacco smoke that causes activating mutations in Kras and induces lung tumors in mice." ], "offsets": [ [ 0, 130 ] ] } ]
[ { "id": "DS.d557.s0.e0", "type": "compound", "text": [ "Urethane" ], "offsets": [ [ 0, 8 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5641" } ] }, { "id": "DS.d557.s0.e1", "type": "protein", "text": [ "Kras" ], "offsets": [ [ 93, 97 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P08644" }, { "db_name": "UniProt", "db_id": "P32883" }, { "db_name": "UniProt", "db_id": "Q05147" } ] } ]
[]
[]
[ { "id": "DS.d557.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d557.s0.e0", "arg2_id": "DS.d557.s0.e1", "normalized": [] } ]
DS.d558
18636040
[ { "id": "DS.d558.s0", "type": "", "text": [ "In the present study, we measured plasma GSTA1-1 levels by enzyme-linked immunosorbent assay in seven healthy volunteers after repeated experimental endotoxemia induced by 2 ng kg Escherichia coli endotoxin per day (to investigate inflammation-induced hepatic injury) and in 21 patients within 12 h after the occurrence of severe sepsis/septic shock (to investigate its ability to predict an increase of transaminases on day 7)." ], "offsets": [ [ 0, 428 ] ] }, { "id": "DS.d558.s1", "type": "", "text": [ "Furthermore, GSTA1-1 levels did not correlate with IL-6 levels but did with dobutamine infusion rate (Spearman r = 0.94; P = 0.02), suggesting that the extent of hemodynamic instability and not the degree of inflammation could be of importance for the occurrence of liver damage." ], "offsets": [ [ 429, 708 ] ] } ]
[ { "id": "DS.d558.s0.e0", "type": "protein", "text": [ "GSTA1-1" ], "offsets": [ [ 41, 48 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P08263" }, { "db_name": "UniProt", "db_id": "Q08863" } ] }, { "id": "DS.d558.s0.e1", "type": "compound", "text": [ "endotoxin" ], "offsets": [ [ 197, 206 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "44268108" } ] }, { "id": "DS.d558.s1.e0", "type": "protein", "text": [ "GSTA1-1" ], "offsets": [ [ 442, 449 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P08263" }, { "db_name": "UniProt", "db_id": "Q08863" } ] }, { "id": "DS.d558.s1.e1", "type": "protein", "text": [ "IL-6" ], "offsets": [ [ 480, 484 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O35736" }, { "db_name": "UniProt", "db_id": "P05231" }, { "db_name": "UniProt", "db_id": "P08505" }, { "db_name": "UniProt", "db_id": "P20607" }, { "db_name": "UniProt", "db_id": "P26892" }, { "db_name": "UniProt", "db_id": "P26893" }, { "db_name": "UniProt", "db_id": "P29455" }, { "db_name": "UniProt", "db_id": "P41323" }, { "db_name": "UniProt", "db_id": "P41683" }, { "db_name": "UniProt", "db_id": "P41693" }, { "db_name": "UniProt", "db_id": "P46650" }, { "db_name": "UniProt", "db_id": "P51494" }, { "db_name": "UniProt", "db_id": "P79341" }, { "db_name": "UniProt", "db_id": "Q25BC2" }, { "db_name": "UniProt", "db_id": "Q28319" }, { "db_name": "UniProt", "db_id": "Q28747" }, { "db_name": "UniProt", "db_id": "Q28819" }, { "db_name": "UniProt", "db_id": "Q2MH06" }, { "db_name": "UniProt", "db_id": "Q5I6E3" }, { "db_name": "UniProt", "db_id": "Q6V919" }, { "db_name": "UniProt", "db_id": "Q865W7" }, { "db_name": "UniProt", "db_id": "Q865X6" }, { "db_name": "UniProt", "db_id": "Q8MKH0" }, { "db_name": "UniProt", "db_id": "Q95181" }, { "db_name": "UniProt", "db_id": "Q9MZR1" }, { "db_name": "UniProt", "db_id": "Q9XT80" } ] }, { "id": "DS.d558.s1.e2", "type": "compound", "text": [ "dobutamine" ], "offsets": [ [ 505, 515 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "36811" } ] } ]
[]
[]
[ { "id": "DS.d558.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d558.s1.e2", "arg2_id": "DS.d558.s1.e0", "normalized": [] } ]
DS.d559
18636042
[ { "id": "DS.d559.s0", "type": "", "text": [ "Heparin (H), argatroban (A), antithrombin III (ATIII), and recombinant human activated protein C (rhAPC) with and without thrombin were added to cells suspended in septic plasma and normal plasma." ], "offsets": [ [ 0, 196 ] ] } ]
[ { "id": "DS.d559.s0.e0", "type": "compound", "text": [ "argatroban" ], "offsets": [ [ 13, 23 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2232" }, { "db_name": "PubChem", "db_id": "92722" }, { "db_name": "PubChem", "db_id": "152951" }, { "db_name": "PubChem", "db_id": "440542" }, { "db_name": "PubChem", "db_id": "445156" } ] }, { "id": "DS.d559.s0.e1", "type": "protein", "text": [ "antithrombin III" ], "offsets": [ [ 29, 45 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P81050" } ] }, { "id": "DS.d559.s0.e2", "type": "protein", "text": [ "ATIII" ], "offsets": [ [ 47, 52 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01008" }, { "db_name": "UniProt", "db_id": "P32261" }, { "db_name": "UniProt", "db_id": "P32262" }, { "db_name": "UniProt", "db_id": "P41361" }, { "db_name": "UniProt", "db_id": "P81050" }, { "db_name": "UniProt", "db_id": "Q03352" }, { "db_name": "UniProt", "db_id": "Q5R5A3" } ] }, { "id": "DS.d559.s0.e3", "type": "protein", "text": [ "protein C" ], "offsets": [ [ 87, 96 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O55527" }, { "db_name": "UniProt", "db_id": "O55779" }, { "db_name": "UniProt", "db_id": "P02810" }, { "db_name": "UniProt", "db_id": "P03314" }, { "db_name": "UniProt", "db_id": "P03424" }, { "db_name": "UniProt", "db_id": "P04861" }, { "db_name": "UniProt", "db_id": "P04862" }, { "db_name": "UniProt", "db_id": "P06022" }, { "db_name": "UniProt", "db_id": "P06164" }, { "db_name": "UniProt", "db_id": "P06165" }, { "db_name": "UniProt", "db_id": "P06941" }, { "db_name": "UniProt", "db_id": "P07602" }, { "db_name": "UniProt", "db_id": "P08097" }, { "db_name": "UniProt", "db_id": "P10030" }, { "db_name": "UniProt", "db_id": "P14253" }, { "db_name": "UniProt", "db_id": "P14254" }, { "db_name": "UniProt", "db_id": "P14340" }, { "db_name": "UniProt", "db_id": "P26035" }, { "db_name": "UniProt", "db_id": "P26779" }, { "db_name": "UniProt", "db_id": "P27384" }, { "db_name": "UniProt", "db_id": "P28055" }, { "db_name": "UniProt", "db_id": "P29165" }, { "db_name": "UniProt", "db_id": "P32533" }, { "db_name": "UniProt", "db_id": "P32534" }, { "db_name": "UniProt", "db_id": "P32535" }, { "db_name": "UniProt", "db_id": "P35940" }, { "db_name": "UniProt", "db_id": "P35948" }, { "db_name": "UniProt", "db_id": "P35977" }, { "db_name": "UniProt", "db_id": "P69738" }, { "db_name": "UniProt", "db_id": "Q00794" }, { "db_name": "UniProt", "db_id": "Q03339" }, { "db_name": "UniProt", "db_id": "Q074N0" }, { "db_name": "UniProt", "db_id": "Q1X880" }, { "db_name": "UniProt", "db_id": "Q1X881" }, { "db_name": "UniProt", "db_id": "Q6DV88" }, { "db_name": "UniProt", "db_id": "Q6J3P1" }, { "db_name": "UniProt", "db_id": "Q89277" }, { "db_name": "UniProt", "db_id": "Q98803" }, { "db_name": "UniProt", "db_id": "Q997F1" }, { "db_name": "UniProt", "db_id": "Q9DUE0" }, { "db_name": "UniProt", "db_id": "Q9WS38" }, { "db_name": "UniProt", "db_id": "Q9YRV3" } ] }, { "id": "DS.d559.s0.e4", "type": "protein", "text": [ "thrombin" ], "offsets": [ [ 33, 41 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P84122" } ] } ]
[]
[]
[]
DS.d560
18636044
[ { "id": "DS.d560.s0", "type": "", "text": [ "Hydrogen sulfide (H2S) is a novel gaseous mediator produced by cystathionine-beta-synthase and cystathionine-gamma-lyase in the cardiovascular system, including the heart." ], "offsets": [ [ 0, 171 ] ] } ]
[ { "id": "DS.d560.s0.e0", "type": "compound", "text": [ "Hydrogen sulfide" ], "offsets": [ [ 0, 16 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "402" }, { "db_name": "PubChem", "db_id": "108196" } ] }, { "id": "DS.d560.s0.e1", "type": "compound", "text": [ "H2S" ], "offsets": [ [ 18, 21 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6857678" } ] }, { "id": "DS.d560.s0.e2", "type": "protein", "text": [ "cystathionine-beta-synthase" ], "offsets": [ [ 63, 90 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P32232" }, { "db_name": "UniProt", "db_id": "P32582" }, { "db_name": "UniProt", "db_id": "P35520" }, { "db_name": "UniProt", "db_id": "P46794" }, { "db_name": "UniProt", "db_id": "Q58H57" }, { "db_name": "UniProt", "db_id": "Q91WT9" }, { "db_name": "UniProt", "db_id": "Q9N0V7" }, { "db_name": "UniProt", "db_id": "Q9YBL2" } ] }, { "id": "DS.d560.s0.e3", "type": "protein", "text": [ "cystathionine-gamma-lyase" ], "offsets": [ [ 95, 120 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P18757" }, { "db_name": "UniProt", "db_id": "P31373" }, { "db_name": "UniProt", "db_id": "P32929" }, { "db_name": "UniProt", "db_id": "Q58DW2" }, { "db_name": "UniProt", "db_id": "Q60HG7" }, { "db_name": "UniProt", "db_id": "Q8VCN5" } ] } ]
[]
[]
[ { "id": "DS.d560.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d560.s0.e0", "arg2_id": "DS.d560.s0.e2", "normalized": [] }, { "id": "DS.d560.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d560.s0.e1", "arg2_id": "DS.d560.s0.e2", "normalized": [] }, { "id": "DS.d560.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d560.s0.e0", "arg2_id": "DS.d560.s0.e3", "normalized": [] }, { "id": "DS.d560.s0.i3", "type": "compound-protein-interaction", "arg1_id": "DS.d560.s0.e1", "arg2_id": "DS.d560.s0.e3", "normalized": [] } ]
DS.d561
18636221
[ { "id": "DS.d561.s0", "type": "", "text": [ "Chemotaxis, lysozyme release and superoxide anion production have been measured." ], "offsets": [ [ 0, 80 ] ] } ]
[ { "id": "DS.d561.s0.e0", "type": "protein", "text": [ "lysozyme" ], "offsets": [ [ 12, 20 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O64362" }, { "db_name": "UniProt", "db_id": "O80288" }, { "db_name": "UniProt", "db_id": "O80292" }, { "db_name": "UniProt", "db_id": "P00720" }, { "db_name": "UniProt", "db_id": "P03706" }, { "db_name": "UniProt", "db_id": "P07540" }, { "db_name": "UniProt", "db_id": "P09963" }, { "db_name": "UniProt", "db_id": "P10439" }, { "db_name": "UniProt", "db_id": "P11187" }, { "db_name": "UniProt", "db_id": "P13656" }, { "db_name": "UniProt", "db_id": "P15057" }, { "db_name": "UniProt", "db_id": "P19385" }, { "db_name": "UniProt", "db_id": "P19386" }, { "db_name": "UniProt", "db_id": "P21270" }, { "db_name": "UniProt", "db_id": "P23472" }, { "db_name": "UniProt", "db_id": "P23473" }, { "db_name": "UniProt", "db_id": "P27359" }, { "db_name": "UniProt", "db_id": "P33486" }, { "db_name": "UniProt", "db_id": "P37715" }, { "db_name": "UniProt", "db_id": "P39046" }, { "db_name": "UniProt", "db_id": "P51771" }, { "db_name": "UniProt", "db_id": "P62692" }, { "db_name": "UniProt", "db_id": "P62693" }, { "db_name": "UniProt", "db_id": "P68920" }, { "db_name": "UniProt", "db_id": "P68921" }, { "db_name": "UniProt", "db_id": "P81241" }, { "db_name": "UniProt", "db_id": "P82174" }, { "db_name": "UniProt", "db_id": "P82175" }, { "db_name": "UniProt", "db_id": "P83673" }, { "db_name": "UniProt", "db_id": "Q27650" }, { "db_name": "UniProt", "db_id": "Q37875" }, { "db_name": "UniProt", "db_id": "Q37896" }, { "db_name": "UniProt", "db_id": "Q48603" }, { "db_name": "UniProt", "db_id": "Q7SID7" }, { "db_name": "UniProt", "db_id": "Q9CIT4" }, { "db_name": "UniProt", "db_id": "Q9T1X2" }, { "db_name": "UniProt", "db_id": "Q9ZXB7" } ] }, { "id": "DS.d561.s0.e1", "type": "compound", "text": [ "superoxide" ], "offsets": [ [ 33, 43 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5359597" } ] } ]
[]
[]
[]
DS.d562
18636241
[ { "id": "DS.d562.s0", "type": "", "text": [ "According to annexin V-binding, arsenic trioxide (7 microM) within 48 h significantly increased phosphatidylserine exposure of human erythrocytes without inducing hemolysis." ], "offsets": [ [ 0, 173 ] ] }, { "id": "DS.d562.s1", "type": "", "text": [ "Removal of extracellular Ca2+ or inhibition of the Ca2+-permeable cation channels with amiloride blunted the effects of arsenic on annexin V-binding and cell shrinkage." ], "offsets": [ [ 174, 342 ] ] } ]
[ { "id": "DS.d562.s0.e0", "type": "protein", "text": [ "annexin V" ], "offsets": [ [ 13, 22 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P08758" }, { "db_name": "UniProt", "db_id": "P14668" }, { "db_name": "UniProt", "db_id": "P17153" }, { "db_name": "UniProt", "db_id": "P48036" }, { "db_name": "UniProt", "db_id": "P70075" }, { "db_name": "UniProt", "db_id": "P81287" }, { "db_name": "UniProt", "db_id": "Q4R4H7" }, { "db_name": "UniProt", "db_id": "Q5R1W0" } ] }, { "id": "DS.d562.s0.e1", "type": "compound", "text": [ "phosphatidylserine" ], "offsets": [ [ 96, 114 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "445141" }, { "db_name": "PubChem", "db_id": "6323481" }, { "db_name": "PubChem", "db_id": "44147587" } ] }, { "id": "DS.d562.s1.e0", "type": "compound", "text": [ "amiloride" ], "offsets": [ [ 261, 270 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "16231" } ] }, { "id": "DS.d562.s1.e1", "type": "protein", "text": [ "annexin V" ], "offsets": [ [ 305, 314 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P08758" }, { "db_name": "UniProt", "db_id": "P14668" }, { "db_name": "UniProt", "db_id": "P17153" }, { "db_name": "UniProt", "db_id": "P48036" }, { "db_name": "UniProt", "db_id": "P70075" }, { "db_name": "UniProt", "db_id": "P81287" }, { "db_name": "UniProt", "db_id": "Q4R4H7" }, { "db_name": "UniProt", "db_id": "Q5R1W0" } ] } ]
[]
[]
[ { "id": "DS.d562.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d562.s1.e0", "arg2_id": "DS.d562.s1.e1", "normalized": [] } ]
DS.d563
18636311
[ { "id": "DS.d563.s0", "type": "", "text": [ "In the present study, we investigated the inhibitory effect of the known oxycoumarins poncitrin (3), osthol (4), and xanthoxyletin (5), newly isolated from Clausena guillauminii (Rutaceae), together with the known carbazoles heptaphylline (1) and 7-methoxyheptaphylline (2) on inducible-nitric oxide synthase (iNOS) expression induced by lipopolysaccharide (LPS) and the NO generation in RAW 264.7 mouse macrophages." ], "offsets": [ [ 0, 416 ] ] } ]
[ { "id": "DS.d563.s0.e0", "type": "compound", "text": [ "osthol" ], "offsets": [ [ 101, 107 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "10228" } ] }, { "id": "DS.d563.s0.e1", "type": "compound", "text": [ "xanthoxyletin" ], "offsets": [ [ 117, 130 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "66548" } ] }, { "id": "DS.d563.s0.e2", "type": "compound", "text": [ "heptaphylline" ], "offsets": [ [ 225, 238 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5318015" } ] }, { "id": "DS.d563.s0.e3", "type": "protein", "text": [ "nitric oxide synthase" ], "offsets": [ [ 287, 308 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O61309" }, { "db_name": "UniProt", "db_id": "O61608" }, { "db_name": "UniProt", "db_id": "Q27571" }, { "db_name": "UniProt", "db_id": "Q9I9M2" } ] }, { "id": "DS.d563.s0.e4", "type": "protein", "text": [ "iNOS" ], "offsets": [ [ 310, 314 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O19114" }, { "db_name": "UniProt", "db_id": "O46660" }, { "db_name": "UniProt", "db_id": "O54705" }, { "db_name": "UniProt", "db_id": "O62699" }, { "db_name": "UniProt", "db_id": "P29477" }, { "db_name": "UniProt", "db_id": "P35228" }, { "db_name": "UniProt", "db_id": "P79290" }, { "db_name": "UniProt", "db_id": "Q06518" }, { "db_name": "UniProt", "db_id": "Q27995" }, { "db_name": "UniProt", "db_id": "Q28314" }, { "db_name": "UniProt", "db_id": "Q90703" }, { "db_name": "UniProt", "db_id": "Q92037" }, { "db_name": "UniProt", "db_id": "Q92091" } ] }, { "id": "DS.d563.s0.e5", "type": "compound", "text": [ "lipopolysaccharide" ], "offsets": [ [ 338, 356 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "11970143" } ] } ]
[]
[]
[]
DS.d564
18636399
[ { "id": "DS.d564.s0", "type": "", "text": [ "Cell viability and reactive oxygen species concentration were determined, and the effects of pre-treatment with LA on these parameters were investigated together with the GST and GPx activity as well as the concentration of reduced glutathione." ], "offsets": [ [ 0, 244 ] ] } ]
[ { "id": "DS.d564.s0.e0", "type": "compound", "text": [ "oxygen" ], "offsets": [ [ 28, 34 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "977" } ] }, { "id": "DS.d564.s0.e1", "type": "protein", "text": [ "GST" ], "offsets": [ [ 171, 174 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P20432" }, { "db_name": "UniProt", "db_id": "P30104" }, { "db_name": "UniProt", "db_id": "P30106" }, { "db_name": "UniProt", "db_id": "P30107" }, { "db_name": "UniProt", "db_id": "P30108" }, { "db_name": "UniProt", "db_id": "Q04522" }, { "db_name": "UniProt", "db_id": "Q0ZS46" }, { "db_name": "UniProt", "db_id": "Q7REH6" }, { "db_name": "UniProt", "db_id": "Q8ILQ7" }, { "db_name": "UniProt", "db_id": "Q8MU52" } ] }, { "id": "DS.d564.s0.e2", "type": "compound", "text": [ "reduced glutathione" ], "offsets": [ [ 224, 243 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "124886" } ] } ]
[]
[]
[]
DS.d565
18636508
[ { "id": "DS.d565.s0", "type": "", "text": [ "Fibril growth was a second-order process with an enthalpy of activation (27+/-5 kcal mol(-1)), which is indistinguishable from that of tetramer formation by cystatins, which involves limited conformational changes including proline trans to cis isomerization." ], "offsets": [ [ 0, 259 ] ] } ]
[ { "id": "DS.d565.s0.e0", "type": "protein", "text": [ "cystatins" ], "offsets": [ [ 157, 166 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P08935" }, { "db_name": "UniProt", "db_id": "P25973" }, { "db_name": "UniProt", "db_id": "P81061" }, { "db_name": "UniProt", "db_id": "P81714" }, { "db_name": "UniProt", "db_id": "Q06445" } ] }, { "id": "DS.d565.s0.e1", "type": "compound", "text": [ "proline" ], "offsets": [ [ 224, 231 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "614" }, { "db_name": "PubChem", "db_id": "8988" }, { "db_name": "PubChem", "db_id": "145742" } ] } ]
[]
[]
[ { "id": "DS.d565.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d565.s0.e1", "arg2_id": "DS.d565.s0.e0", "normalized": [] } ]
DS.d566
18636565
[ { "id": "DS.d566.s0", "type": "", "text": [ "Mutations in MCT8 are associated with severe psychomotor retardation, high serum T3 and low 3,3',5'-triiodothyronine (rT3) levels." ], "offsets": [ [ 0, 130 ] ] } ]
[ { "id": "DS.d566.s0.e0", "type": "protein", "text": [ "MCT8" ], "offsets": [ [ 13, 17 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P36021" } ] }, { "id": "DS.d566.s0.e1", "type": "compound", "text": [ "3,3',5'-triiodothyronine" ], "offsets": [ [ 92, 116 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5920" }, { "db_name": "PubChem", "db_id": "644280" } ] }, { "id": "DS.d566.s0.e2", "type": "compound", "text": [ "rT3" ], "offsets": [ [ 118, 121 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "644280" } ] } ]
[]
[]
[ { "id": "DS.d566.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d566.s0.e1", "arg2_id": "DS.d566.s0.e0", "normalized": [] }, { "id": "DS.d566.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d566.s0.e2", "arg2_id": "DS.d566.s0.e0", "normalized": [] } ]
DS.d567
18637152
[ { "id": "DS.d567.s0", "type": "", "text": [ "Results showed that MENT treatments increased PSA secretion and proliferation rate with a potency ranged between T and DHT." ], "offsets": [ [ 0, 123 ] ] }, { "id": "DS.d567.s1", "type": "", "text": [ "The studies with finasteride showed that in BPH and CaP cells, the conversion of T into DHT significantly contributes to its effect on the proliferation and PSA secretion, and corroborated the resistance of MENT to the 5-AR." ], "offsets": [ [ 124, 348 ] ] } ]
[ { "id": "DS.d567.s0.e0", "type": "compound", "text": [ "MENT" ], "offsets": [ [ 20, 24 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "19582" }, { "db_name": "PubChem", "db_id": "9838899" } ] }, { "id": "DS.d567.s0.e1", "type": "protein", "text": [ "PSA" ], "offsets": [ [ 46, 49 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P07288" }, { "db_name": "UniProt", "db_id": "P10658" }, { "db_name": "UniProt", "db_id": "P33619" }, { "db_name": "UniProt", "db_id": "P55786" }, { "db_name": "UniProt", "db_id": "Q11011" }, { "db_name": "UniProt", "db_id": "Q6DT45" }, { "db_name": "UniProt", "db_id": "Q9Y617" } ] }, { "id": "DS.d567.s0.e2", "type": "compound", "text": [ "DHT" ], "offsets": [ [ 119, 122 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "10635" } ] }, { "id": "DS.d567.s1.e0", "type": "compound", "text": [ "finasteride" ], "offsets": [ [ 141, 152 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "57363" } ] }, { "id": "DS.d567.s1.e1", "type": "compound", "text": [ "DHT" ], "offsets": [ [ 212, 215 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "10635" } ] }, { "id": "DS.d567.s1.e2", "type": "protein", "text": [ "PSA" ], "offsets": [ [ 281, 284 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P07288" }, { "db_name": "UniProt", "db_id": "P10658" }, { "db_name": "UniProt", "db_id": "P33619" }, { "db_name": "UniProt", "db_id": "P55786" }, { "db_name": "UniProt", "db_id": "Q11011" }, { "db_name": "UniProt", "db_id": "Q6DT45" }, { "db_name": "UniProt", "db_id": "Q9Y617" } ] }, { "id": "DS.d567.s1.e3", "type": "compound", "text": [ "MENT" ], "offsets": [ [ 331, 335 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "19582" }, { "db_name": "PubChem", "db_id": "9838899" } ] } ]
[]
[]
[ { "id": "DS.d567.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d567.s0.e2", "arg2_id": "DS.d567.s0.e1", "normalized": [] }, { "id": "DS.d567.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d567.s0.e0", "arg2_id": "DS.d567.s0.e1", "normalized": [] }, { "id": "DS.d567.s1.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d567.s1.e1", "arg2_id": "DS.d567.s1.e2", "normalized": [] } ]
DS.d568
18637154
[ { "id": "DS.d568.s0", "type": "", "text": [ "Pregnant Sprague-Dawley female rats were treated once with TCDD (0, 0.3 or 1 microg/kg) by gavage on embryonic day (ED) 11 and the expression levels of androgen (AR) and estrogen receptors (ER), steroidogenic enzymes (P450scc and 3beta-HSD) and four regulatory factors (StAR, SF-1, GATA-4 and Insl-3) involved in foetal Leydig cell and adrenal function were analysed on ED 19.5." ], "offsets": [ [ 0, 378 ] ] }, { "id": "DS.d568.s1", "type": "", "text": [ "In utero exposure to TCDD reduced intratesticular T of foetal males (significant at 0.3 microg/kg TCDD) and tended to reduce the protein expression of ERalpha and AR of foetal male rat testis." ], "offsets": [ [ 379, 571 ] ] }, { "id": "DS.d568.s2", "type": "", "text": [ "mRNA expression of developmental regulatory factors was not influenced by foetal TCDD exposure, except for significantly reduced adrenal SF-1." ], "offsets": [ [ 572, 714 ] ] } ]
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{ "db_name": "UniProt", "db_id": "Q53AD2" }, { "db_name": "UniProt", "db_id": "Q91250" }, { "db_name": "UniProt", "db_id": "Q91424" }, { "db_name": "UniProt", "db_id": "Q9PVZ9" }, { "db_name": "UniProt", "db_id": "Q9QZJ5" }, { "db_name": "UniProt", "db_id": "Q9TV98" }, { "db_name": "UniProt", "db_id": "Q9YH33" }, { "db_name": "UniProt", "db_id": "Q9YHT3" }, { "db_name": "UniProt", "db_id": "Q9YHZ7" } ] }, { "id": "DS.d568.s0.e2", "type": "protein", "text": [ "3beta-HSD" ], "offsets": [ [ 230, 239 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O46516" }, { "db_name": "UniProt", "db_id": "O57245" }, { "db_name": "UniProt", "db_id": "P14893" }, { "db_name": "UniProt", "db_id": "P21097" }, { "db_name": "UniProt", "db_id": "P26670" }, { "db_name": "UniProt", "db_id": "P27365" }, { "db_name": "UniProt", "db_id": "Q5IFP1" }, { "db_name": "UniProt", "db_id": "Q67477" }, { "db_name": "UniProt", "db_id": "Q9N119" } ] }, { "id": "DS.d568.s0.e3", "type": "protein", "text": [ "StAR" ], "offsets": [ [ 270, 274 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O46689" }, { "db_name": "UniProt", "db_id": "P49675" }, { "db_name": "UniProt", "db_id": "P51557" }, { "db_name": "UniProt", "db_id": "P58864" }, { "db_name": "UniProt", "db_id": "P70114" }, { "db_name": "UniProt", "db_id": "P79245" }, { "db_name": "UniProt", "db_id": "P97826" }, { "db_name": "UniProt", "db_id": "Q28918" }, { "db_name": "UniProt", "db_id": "Q28996" }, { "db_name": "UniProt", "db_id": "Q9DE06" }, { "db_name": "UniProt", "db_id": "Q9DEB4" }, { "db_name": "UniProt", "db_id": "Q9DG08" }, { "db_name": "UniProt", "db_id": "Q9DG09" }, { "db_name": "UniProt", "db_id": "Q9DG10" } ] }, { "id": "DS.d568.s0.e4", "type": "protein", "text": [ "SF-1" ], "offsets": [ [ 276, 280 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P33242" }, { "db_name": "UniProt", "db_id": "P50569" }, { "db_name": "UniProt", "db_id": "P79387" }, { "db_name": "UniProt", "db_id": "Q04752" }, { "db_name": "UniProt", "db_id": "Q13285" }, { "db_name": "UniProt", "db_id": "Q95L87" }, { "db_name": "UniProt", "db_id": "Q9GKL2" } ] }, { "id": "DS.d568.s0.e5", "type": "protein", "text": [ "GATA" ], "offsets": [ [ 282, 286 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P49604" } ] }, { "id": "DS.d568.s1.e0", "type": "compound", "text": [ "TCDD" ], "offsets": [ [ 400, 404 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "15625" } ] }, { "id": "DS.d568.s1.e1", "type": "compound", "text": [ "TCDD" ], "offsets": [ [ 477, 481 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "15625" } ] }, { "id": "DS.d568.s1.e2", "type": "protein", "text": [ "ERalpha" ], "offsets": [ [ 530, 537 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O42132" }, { "db_name": "UniProt", "db_id": "P03372" }, { "db_name": "UniProt", "db_id": "P06211" }, { "db_name": "UniProt", "db_id": "P06212" }, { "db_name": "UniProt", "db_id": "P16058" }, { "db_name": "UniProt", "db_id": "P19785" }, { "db_name": "UniProt", "db_id": "P49884" }, { "db_name": "UniProt", "db_id": "P49885" }, { "db_name": "UniProt", "db_id": "P49886" }, { "db_name": "UniProt", "db_id": "P50240" }, { "db_name": "UniProt", "db_id": "P50241" }, { "db_name": "UniProt", "db_id": "P50242" }, { "db_name": "UniProt", "db_id": "P57717" }, { "db_name": "UniProt", "db_id": "P57753" }, { "db_name": "UniProt", "db_id": "P81559" }, { "db_name": "UniProt", "db_id": "Q29040" }, { "db_name": "UniProt", "db_id": "Q53AD2" }, { "db_name": "UniProt", "db_id": "Q91250" }, { "db_name": "UniProt", "db_id": "Q91424" }, { "db_name": "UniProt", "db_id": "Q9PVZ9" }, { "db_name": "UniProt", "db_id": "Q9QZJ5" }, { "db_name": "UniProt", "db_id": "Q9TV98" }, { "db_name": "UniProt", "db_id": "Q9YH33" }, { "db_name": "UniProt", "db_id": "Q9YHT3" }, { "db_name": "UniProt", "db_id": "Q9YHZ7" } ] }, { "id": "DS.d568.s2.e0", "type": "compound", "text": [ "TCDD" ], "offsets": [ [ 653, 657 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "15625" } ] }, { "id": "DS.d568.s2.e1", "type": "protein", "text": [ "SF-1" ], "offsets": [ [ 709, 713 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P33242" }, { "db_name": "UniProt", "db_id": "P50569" }, { "db_name": "UniProt", "db_id": "P79387" }, { "db_name": "UniProt", "db_id": "Q04752" }, { "db_name": "UniProt", "db_id": "Q13285" }, { "db_name": "UniProt", "db_id": "Q95L87" }, { "db_name": "UniProt", "db_id": "Q9GKL2" } ] } ]
[]
[]
[ { "id": "DS.d568.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d568.s1.e0", "arg2_id": "DS.d568.s1.e2", "normalized": [] }, { "id": "DS.d568.s2.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d568.s2.e0", "arg2_id": "DS.d568.s2.e1", "normalized": [] } ]
DS.d569
18637708
[ { "id": "DS.d569.s0", "type": "", "text": [ "Nitrogen-containing bisphosphonates were found to inhibit farnesyl diphosphate synthase-an essential enzyme in the cholesterol biosynthesis pathway, but their effect on cholesterol synthesis per se in the central nervous system (CNS) remains unknown." ], "offsets": [ [ 0, 250 ] ] } ]
[ { "id": "DS.d569.s0.e0", "type": "compound", "text": [ "Nitrogen" ], "offsets": [ [ 0, 8 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "947" }, { "db_name": "PubChem", "db_id": "123329" } ] }, { "id": "DS.d569.s0.e1", "type": "protein", "text": [ "farnesyl diphosphate synthase" ], "offsets": [ [ 58, 87 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O66126" }, { "db_name": "UniProt", "db_id": "O66952" }, { "db_name": "UniProt", "db_id": "P22939" }, { "db_name": "UniProt", "db_id": "P45204" }, { "db_name": "UniProt", "db_id": "P54383" }, { "db_name": "UniProt", "db_id": "P55539" }, { "db_name": "UniProt", "db_id": "P57537" }, { "db_name": "UniProt", "db_id": "Q08291" }, { "db_name": "UniProt", "db_id": "Q45220" }, { "db_name": "UniProt", "db_id": "Q8K9A0" } ] }, { "id": "DS.d569.s0.e2", "type": "compound", "text": [ "cholesterol" ], "offsets": [ [ 115, 126 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "304" }, { "db_name": "PubChem", "db_id": "5997" }, { "db_name": "PubChem", "db_id": "6432564" }, { "db_name": "PubChem", "db_id": "11025495" } ] } ]
[]
[]
[ { "id": "DS.d569.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d569.s0.e2", "arg2_id": "DS.d569.s0.e1", "normalized": [] } ]
DS.d570
18637712
[ { "id": "DS.d570.s0", "type": "", "text": [ "hsBAFF-upregulated intracellular free Ca(2+) homeostasis regulates ERK1/2 activity and cell proliferation in B cells in vitro." ], "offsets": [ [ 0, 126 ] ] }, { "id": "DS.d570.s1", "type": "", "text": [ "Using immunocytochemistry and Western blot analysis, we found that the activation of ERK1/2 due to hsBAFF was triggered by a (Ca(2+))(i)-dependent pathway, leading to elevation of B cell proliferation." ], "offsets": [ [ 127, 328 ] ] }, { "id": "DS.d570.s2", "type": "", "text": [ "This is supported by the findings that intracellular Ca(2+) chelator BAPTA/AM attenuated phosphorylated ERK1/2 expression and cell proliferation in hsBAFF-stimulated B cells." ], "offsets": [ [ 329, 503 ] ] }, { "id": "DS.d570.s3", "type": "", "text": [ "Taken together, the main finding of this study is that hsBAFF elicits higher but homeostatic (Ca(2+))(i) levels, which regulates ERK1/2 activity and cell proliferation in in vitro B cells." ], "offsets": [ [ 504, 692 ] ] } ]
[ { "id": "DS.d570.s0.e0", "type": "compound", "text": [ "Ca(2" ], "offsets": [ [ 38, 42 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "271" } ] }, { "id": "DS.d570.s0.e1", "type": "protein", "text": [ "ERK1" ], "offsets": [ [ 67, 71 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P27361" }, { "db_name": "UniProt", "db_id": "P28869" }, { "db_name": "UniProt", "db_id": "P42525" }, { "db_name": "UniProt", "db_id": "Q07176" } ] }, { "id": "DS.d570.s1.e0", "type": "protein", "text": [ "ERK1" ], "offsets": [ [ 212, 216 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P27361" }, { "db_name": "UniProt", "db_id": "P28869" }, { "db_name": "UniProt", "db_id": "P42525" }, { "db_name": "UniProt", "db_id": "Q07176" } ] }, { "id": "DS.d570.s1.e1", "type": "compound", "text": [ "Ca(2" ], "offsets": [ [ 253, 257 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "271" } ] }, { "id": "DS.d570.s2.e0", "type": "compound", "text": [ "BAPTA/AM" ], "offsets": [ [ 398, 406 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2293" } ] }, { "id": "DS.d570.s2.e1", "type": "protein", "text": [ "ERK1" ], "offsets": [ [ 433, 437 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P27361" }, { "db_name": "UniProt", "db_id": "P28869" }, { "db_name": "UniProt", "db_id": "P42525" }, { "db_name": "UniProt", "db_id": "Q07176" } ] }, { "id": "DS.d570.s3.e0", "type": "compound", "text": [ "Ca(2" ], "offsets": [ [ 598, 602 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "271" } ] }, { "id": "DS.d570.s3.e1", "type": "protein", "text": [ "ERK1" ], "offsets": [ [ 633, 637 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P27361" }, { "db_name": "UniProt", "db_id": "P28869" }, { "db_name": "UniProt", "db_id": "P42525" }, { "db_name": "UniProt", "db_id": "Q07176" } ] } ]
[]
[]
[ { "id": "DS.d570.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d570.s0.e0", "arg2_id": "DS.d570.s0.e1", "normalized": [] }, { "id": "DS.d570.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d570.s1.e1", "arg2_id": "DS.d570.s1.e0", "normalized": [] }, { "id": "DS.d570.s2.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d570.s2.e0", "arg2_id": "DS.d570.s2.e1", "normalized": [] }, { "id": "DS.d570.s3.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d570.s3.e0", "arg2_id": "DS.d570.s3.e1", "normalized": [] } ]
DS.d571
18637714
[ { "id": "DS.d571.s0", "type": "", "text": [ "Surgical removal of pheochromocytoma significantly increased body weight, decreased both systolic and diastolic blood pressure, fasting blood glucose and glycated hemoglobin levels." ], "offsets": [ [ 0, 181 ] ] } ]
[ { "id": "DS.d571.s0.e0", "type": "compound", "text": [ "glucose" ], "offsets": [ [ 142, 149 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "206" }, { "db_name": "PubChem", "db_id": "5793" }, { "db_name": "PubChem", "db_id": "64689" }, { "db_name": "PubChem", "db_id": "79025" } ] }, { "id": "DS.d571.s0.e1", "type": "protein", "text": [ "hemoglobin" ], "offsets": [ [ 163, 173 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P15160" }, { "db_name": "UniProt", "db_id": "P17724" }, { "db_name": "UniProt", "db_id": "P73925" }, { "db_name": "UniProt", "db_id": "Q03459" } ] } ]
[]
[]
[]
DS.d572
18637715
[ { "id": "DS.d572.s0", "type": "", "text": [ "In this study we have investigated a long-term pattern of expression and production of spinal COX-1 and COX-2 in the model of osteoarthritis induced in rats by injection of monoiodoacetate (MIA) into the knee joint." ], "offsets": [ [ 0, 215 ] ] } ]
[ { "id": "DS.d572.s0.e0", "type": "protein", "text": [ "COX-1" ], "offsets": [ [ 94, 99 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O62664" }, { "db_name": "UniProt", "db_id": "O97554" }, { "db_name": "UniProt", "db_id": "P05979" }, { "db_name": "UniProt", "db_id": "P22437" }, { "db_name": "UniProt", "db_id": "P23219" }, { "db_name": "UniProt", "db_id": "Q63921" }, { "db_name": "UniProt", "db_id": "Q9T0N8" } ] }, { "id": "DS.d572.s0.e1", "type": "protein", "text": [ "COX-2" ], "offsets": [ [ 104, 109 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O02768" }, { "db_name": "UniProt", "db_id": "O19183" }, { "db_name": "UniProt", "db_id": "O62698" }, { "db_name": "UniProt", "db_id": "O62725" }, { "db_name": "UniProt", "db_id": "P27607" }, { "db_name": "UniProt", "db_id": "P35354" }, { "db_name": "UniProt", "db_id": "P35355" }, { "db_name": "UniProt", "db_id": "P70682" }, { "db_name": "UniProt", "db_id": "P79208" }, { "db_name": "UniProt", "db_id": "Q05769" } ] }, { "id": "DS.d572.s0.e2", "type": "compound", "text": [ "monoiodoacetate" ], "offsets": [ [ 173, 188 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5240" } ] } ]
[]
[]
[]
DS.d573
18639339
[ { "id": "DS.d573.s0", "type": "", "text": [ "The enzyme indoleamine 2,3-dioxygenase (IDO) converts tryptophan to kynurenine, blocking T-cell activation and inducing immunosuppression." ], "offsets": [ [ 0, 138 ] ] } ]
[ { "id": "DS.d573.s0.e0", "type": "protein", "text": [ "indoleamine 2,3-dioxygenase" ], "offsets": [ [ 11, 38 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P14902" }, { "db_name": "UniProt", "db_id": "P28776" } ] }, { "id": "DS.d573.s0.e1", "type": "protein", "text": [ "IDO" ], "offsets": [ [ 40, 43 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P14902" }, { "db_name": "UniProt", "db_id": "P28776" } ] }, { "id": "DS.d573.s0.e2", "type": "compound", "text": [ "tryptophan" ], "offsets": [ [ 54, 64 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1148" }, { "db_name": "PubChem", "db_id": "6305" }, { "db_name": "PubChem", "db_id": "9060" }, { "db_name": "PubChem", "db_id": "5460840" } ] }, { "id": "DS.d573.s0.e3", "type": "compound", "text": [ "kynurenine" ], "offsets": [ [ 68, 78 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "846" } ] } ]
[]
[]
[ { "id": "DS.d573.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d573.s0.e2", "arg2_id": "DS.d573.s0.e0", "normalized": [] }, { "id": "DS.d573.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d573.s0.e3", "arg2_id": "DS.d573.s0.e1", "normalized": [] }, { "id": "DS.d573.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d573.s0.e2", "arg2_id": "DS.d573.s0.e1", "normalized": [] }, { "id": "DS.d573.s0.i3", "type": "compound-protein-interaction", "arg1_id": "DS.d573.s0.e3", "arg2_id": "DS.d573.s0.e0", "normalized": [] } ]
DS.d574
18639341
[ { "id": "DS.d574.s0", "type": "", "text": [ "Serum l-kynurenine (l-KYN) concentrations, l-KYN/l-TRP ratio, and the level of IDO mRNA expression in ATLL cells were significantly increased in ATLL patients compared to those in healthy and HTLV-positive carrier subjects." ], "offsets": [ [ 0, 223 ] ] } ]
[ { "id": "DS.d574.s0.e0", "type": "compound", "text": [ "kynurenine" ], "offsets": [ [ 8, 18 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "846" } ] }, { "id": "DS.d574.s0.e1", "type": "compound", "text": [ "KYN" ], "offsets": [ [ 22, 25 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "161166" } ] }, { "id": "DS.d574.s0.e2", "type": "compound", "text": [ "KYN" ], "offsets": [ [ 45, 48 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "161166" } ] }, { "id": "DS.d574.s0.e3", "type": "protein", "text": [ "TRP" ], "offsets": [ [ 51, 54 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P07147" }, { "db_name": "UniProt", "db_id": "P17643" } ] }, { "id": "DS.d574.s0.e4", "type": "protein", "text": [ "IDO" ], "offsets": [ [ 79, 82 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P14902" }, { "db_name": "UniProt", "db_id": "P28776" } ] } ]
[]
[]
[]
DS.d575
18639629
[ { "id": "DS.d575.s0", "type": "", "text": [ "Peripheral administration of the acetylcholinesterase inhibitor galantamine significantly reduced serum TNF levels through vagus nerve signaling, and protected against lethality during murine endotoxemia." ], "offsets": [ [ 0, 204 ] ] }, { "id": "DS.d575.s1", "type": "", "text": [ "Administration of a centrally-acting muscarinic receptor antagonist abolished the suppression of TNF by galantamine, indicating that suppressing acetylcholinesterase activity, coupled with central muscarinic receptors, controls peripheral cytokine responses." ], "offsets": [ [ 205, 463 ] ] }, { "id": "DS.d575.s2", "type": "", "text": [ "Administration of galantamine to alpha7nAChR knockout mice failed to suppress TNF levels, indicating that the alpha7nAChR-mediated cholinergic anti-inflammatory pathway is required for the anti-inflammatory effect of galantamine." ], "offsets": [ [ 464, 693 ] ] } ]
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}, { "db_name": "UniProt", "db_id": "Q1G1A2" }, { "db_name": "UniProt", "db_id": "Q1WM27" }, { "db_name": "UniProt", "db_id": "Q2MH05" }, { "db_name": "UniProt", "db_id": "Q539C2" }, { "db_name": "UniProt", "db_id": "Q75N23" }, { "db_name": "UniProt", "db_id": "Q8HZD9" }, { "db_name": "UniProt", "db_id": "Q8JFG3" }, { "db_name": "UniProt", "db_id": "Q8MKG8" }, { "db_name": "UniProt", "db_id": "Q8WNR1" }, { "db_name": "UniProt", "db_id": "Q9BEA1" } ] }, { "id": "DS.d575.s1.e1", "type": "compound", "text": [ "galantamine" ], "offsets": [ [ 309, 320 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "9651" } ] }, { "id": "DS.d575.s1.e2", "type": "protein", "text": [ "acetylcholinesterase" ], "offsets": [ [ 350, 370 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q867X2" }, { "db_name": "UniProt", "db_id": "Q867X3" }, { "db_name": "UniProt", "db_id": "Q86GC9" }, { "db_name": "UniProt", "db_id": "Q92081" } ] }, { "id": "DS.d575.s2.e0", "type": "compound", "text": [ "galantamine" ], "offsets": [ [ 482, 493 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "9651" } ] }, { "id": "DS.d575.s2.e1", "type": "protein", "text": [ "TNF" ], "offsets": [ [ 542, 545 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O35734" }, { "db_name": "UniProt", "db_id": "O77510" }, { "db_name": "UniProt", "db_id": "O77764" }, { "db_name": "UniProt", "db_id": "P01375" }, { "db_name": "UniProt", "db_id": "P04924" }, { "db_name": "UniProt", "db_id": "P13296" }, { "db_name": "UniProt", "db_id": "P19101" }, { "db_name": "UniProt", "db_id": "P23383" }, { "db_name": "UniProt", "db_id": "P23563" }, { "db_name": "UniProt", "db_id": "P29553" }, { "db_name": "UniProt", "db_id": "P33620" }, { "db_name": "UniProt", "db_id": "P36939" }, { "db_name": "UniProt", "db_id": "P48094" }, { "db_name": "UniProt", "db_id": "P51435" }, { "db_name": "UniProt", "db_id": "P51742" }, { "db_name": "UniProt", "db_id": "P51743" }, { "db_name": "UniProt", "db_id": "P59684" }, { "db_name": "UniProt", "db_id": "P59693" }, { "db_name": "UniProt", "db_id": "P59694" }, { "db_name": "UniProt", "db_id": "P59695" }, { "db_name": "UniProt", "db_id": "P79337" }, { "db_name": "UniProt", "db_id": "P79374" }, { "db_name": "UniProt", "db_id": "Q06599" }, { "db_name": "UniProt", "db_id": "Q19LH4" }, { "db_name": "UniProt", "db_id": "Q1G1A2" }, { "db_name": "UniProt", "db_id": "Q1WM27" }, { "db_name": "UniProt", "db_id": "Q2MH05" }, { "db_name": "UniProt", "db_id": "Q539C2" }, { "db_name": "UniProt", "db_id": "Q75N23" }, { "db_name": "UniProt", "db_id": "Q8HZD9" }, { "db_name": "UniProt", "db_id": "Q8JFG3" }, { "db_name": "UniProt", "db_id": "Q8MKG8" }, { "db_name": "UniProt", "db_id": "Q8WNR1" }, { "db_name": "UniProt", "db_id": "Q9BEA1" } ] }, { "id": "DS.d575.s2.e2", "type": "compound", "text": [ "galantamine" ], "offsets": [ [ 681, 692 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "9651" } ] } ]
[]
[]
[ { "id": "DS.d575.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d575.s0.e0", "arg2_id": "DS.d575.s0.e1", "normalized": [] }, { "id": "DS.d575.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d575.s1.e1", "arg2_id": "DS.d575.s1.e2", "normalized": [] }, { "id": "DS.d575.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d575.s1.e1", "arg2_id": "DS.d575.s1.e0", "normalized": [] } ]
DS.d576
18639930
[ { "id": "DS.d576.s0", "type": "", "text": [ "The involvement of superoxide and nitric oxide was verified by the block of MSC using specific scavengers (tiron and PTIO, respectively)." ], "offsets": [ [ 0, 137 ] ] }, { "id": "DS.d576.s1", "type": "", "text": [ "Accordingly, MSC were blocked by the peroxynitrite scavenger uric acid and could be mimicked by application of exogenous peroxynitrite." ], "offsets": [ [ 138, 273 ] ] }, { "id": "DS.d576.s2", "type": "", "text": [ "This conclusion is supported by our findings that MSC were suppressed by inhibitors of phospholipases but could be mimicked by exogenous phospholipases or by amphipaths (oleic acid, Triton X-100)." ], "offsets": [ [ 274, 470 ] ] } ]
[ { "id": "DS.d576.s0.e0", "type": "compound", "text": [ "superoxide" ], "offsets": [ [ 19, 29 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5359597" } ] }, { "id": "DS.d576.s0.e1", "type": "compound", "text": [ "nitric oxide" ], "offsets": [ [ 34, 46 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "145068" } ] }, { "id": "DS.d576.s0.e2", "type": "protein", "text": [ "MSC" ], "offsets": [ [ 76, 79 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O60682" } ] }, { "id": "DS.d576.s0.e3", "type": "compound", "text": [ "tiron" ], "offsets": [ [ 107, 112 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "9002" } ] }, { "id": "DS.d576.s1.e0", "type": "protein", "text": [ "MSC" ], "offsets": [ [ 151, 154 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O60682" } ] }, { "id": "DS.d576.s1.e2", "type": "compound", "text": [ "uric acid" ], "offsets": [ [ 199, 208 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1175" } ] }, { "id": "DS.d576.s2.e0", "type": "protein", "text": [ "MSC" ], "offsets": [ [ 324, 327 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O60682" } ] }, { "id": "DS.d576.s2.e1", "type": "compound", "text": [ "oleic acid" ], "offsets": [ [ 444, 454 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "445639" } ] }, { "id": "DS.d576.s2.e2", "type": "compound", "text": [ "Triton X-100" ], "offsets": [ [ 456, 468 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5590" } ] } ]
[]
[]
[ { "id": "DS.d576.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d576.s0.e3", "arg2_id": "DS.d576.s0.e2", "normalized": [] }, { "id": "DS.d576.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d576.s1.e2", "arg2_id": "DS.d576.s1.e0", "normalized": [] }, { "id": "DS.d576.s2.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d576.s2.e2", "arg2_id": "DS.d576.s2.e0", "normalized": [] }, { "id": "DS.d576.s2.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d576.s2.e1", "arg2_id": "DS.d576.s2.e0", "normalized": [] } ]
DS.d577
18640003
[ { "id": "DS.d577.s0", "type": "", "text": [ "In the present study, therefore, the effect of FA/AD in presence or absence of p38MAPK inhibitor SB203580 on the proliferation, apoptosis, p38MAPK, caspase-3, location of p38MAPK and caspase-3, and interaction between p38MAPK and caspase-3 in Bel-7402 cell was investigated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide (MTT), annexin V-FITC/propidium iodide (PI) double staining, electron microscopy, immunoblot, immunofluorescence and immunoprecipitation/immunoblot assay, respectively." ], "offsets": [ [ 0, 507 ] ] } ]
[ { "id": "DS.d577.s0.e0", "type": "compound", "text": [ "3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide" ], "offsets": [ [ 277, 338 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "64966" } ] }, { "id": "DS.d577.s0.e1", "type": "protein", "text": [ "annexin V" ], "offsets": [ [ 346, 355 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P08758" }, { "db_name": "UniProt", "db_id": "P14668" }, { "db_name": "UniProt", "db_id": "P17153" }, { "db_name": "UniProt", "db_id": "P48036" }, { "db_name": "UniProt", "db_id": "P70075" }, { "db_name": "UniProt", "db_id": "P81287" }, { "db_name": "UniProt", "db_id": "Q4R4H7" }, { "db_name": "UniProt", "db_id": "Q5R1W0" } ] }, { "id": "DS.d577.s0.e2", "type": "compound", "text": [ "FITC" ], "offsets": [ [ 356, 360 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "18730" } ] }, { "id": "DS.d577.s0.e3", "type": "compound", "text": [ "propidium iodide" ], "offsets": [ [ 361, 377 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "4939" } ] } ]
[]
[]
[]
DS.d578
18640059
[ { "id": "DS.d578.s0", "type": "", "text": [ "To investigate the role of adenosine analogs and electromagnetic field (EMF) stimulation on prostaglandin E(2) (PGE (2)) release and cyclooxygenase-2 (COX-2) expression in bovine synovial fibroblasts (SFs)." ], "offsets": [ [ 0, 206 ] ] } ]
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[]
[]
[]
DS.d579
18640663
[ { "id": "DS.d579.s0", "type": "", "text": [ "In this study, we compared the effects of insulin-like growth factor-I (IGF-I), basic fibroblast growth factor (bFGF), transforming growth factor beta1 (TGF-beta1), and glucosamine sulphate on porcine TMJ condylar cartilage and ankle cartilage cells in monolayer culture." ], "offsets": [ [ 0, 271 ] ] } ]
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[]
[]
[]
DS.d580
18640679
[ { "id": "DS.d580.s0", "type": "", "text": [ "Meanwhile, both the enhanced expression of VCAM-1 and increased activation of NF-kappaB induced by CRH in aortas of LDLr-/-mice were also largely suppressed by NBI27914, whereas these inhibitory effects were not observed in anti-Svg-30 group." ], "offsets": [ [ 0, 242 ] ] } ]
[ { "id": "DS.d580.s0.e0", "type": "protein", "text": [ "VCAM-1" ], "offsets": [ [ 43, 49 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P19320" }, { "db_name": "UniProt", "db_id": "P29533" }, { "db_name": "UniProt", "db_id": "P29534" }, { "db_name": "UniProt", "db_id": "Q28260" } ] }, { "id": "DS.d580.s0.e1", "type": "protein", "text": [ "CRH" ], "offsets": [ [ 99, 102 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01142" }, { "db_name": "UniProt", "db_id": "P06296" }, { "db_name": "UniProt", "db_id": "P06850" }, { "db_name": "UniProt", "db_id": "P49926" }, { "db_name": "UniProt", "db_id": "Q95MI6" }, { "db_name": "UniProt", "db_id": "Q9PTS1" } ] }, { "id": "DS.d580.s0.e2", "type": "compound", "text": [ "NBI27914" ], "offsets": [ [ 160, 168 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "176157" } ] } ]
[]
[]
[ { "id": "DS.d580.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d580.s0.e2", "arg2_id": "DS.d580.s0.e0", "normalized": [] } ]
DS.d581
18640717
[ { "id": "DS.d581.s0", "type": "", "text": [ "PI3K/Akt activity, analyzed by phosphatidylinositol trisphosphate production and phosphorylated Akt (p-Akt) expression, was higher in the resistant cell lines than in the sensitive one and inhibition with wortmannin or LY294002 improved apoptosis in the resistant cell lines." ], "offsets": [ [ 0, 275 ] ] }, { "id": "DS.d581.s1", "type": "", "text": [ "Vincristine but not doxorubicin increased p-Akt expression whereas co-treatment with PI3K inhibitors and vincristine increased apoptosis in the three cell lines." ], "offsets": [ [ 276, 437 ] ] }, { "id": "DS.d581.s2", "type": "", "text": [ "Wortmannin and LY294002 inhibited P-glycoprotein (Pgp) function and also increased NF-kappaB activity." ], "offsets": [ [ 438, 540 ] ] } ]
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[]
[]
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DS.d582
18640746
[ { "id": "DS.d582.s0", "type": "", "text": [ "Namely, the results obtained for the most active compounds, 5-(chloroacetylamino) uracil (2) and its acyclic sugar analogue 18, suggest that formation of a covalent bond between reactive substituent and several possible targets within the thymidylate synthase mechanism (sulphur of the cysteine residue, basic part of the enzyme, N,N-methylene tetrahydrofolate or its reactive iminium forms) is the most probable mode of action." ], "offsets": [ [ 0, 428 ] ] } ]
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"Q9XC19" }, { "db_name": "UniProt", "db_id": "Q9Z671" } ] }, { "id": "DS.d582.s0.e2", "type": "compound", "text": [ "cysteine" ], "offsets": [ [ 286, 294 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "594" }, { "db_name": "PubChem", "db_id": "5862" }, { "db_name": "PubChem", "db_id": "5360637" } ] } ]
[]
[]
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DS.d583
18641920
[ { "id": "DS.d583.s0", "type": "", "text": [ "PTK787/ZK222584, a potent orally active angiogenesis inhibitor capable of inhibiting all known isoforms of Vascular Endothelial Growth Factor (VEGF) receptor, belongs to the class of aminophthalazines." ], "offsets": [ [ 0, 201 ] ] } ]
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[]
[]
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DS.d584
18642040
[ { "id": "DS.d584.s0", "type": "", "text": [ "Recent evidence for toxic superoxide (O(2)(-)) production by marine microalgae is afforded particular attention given that release of O(2)(-) anions can be exacerbated by the binding of mannose-specific lectins to the microalgal cell wall ; a novel model for grazing-activated chemical defence is proposed." ], "offsets": [ [ 0, 306 ] ] } ]
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[]
[]
[ { "id": "DS.d584.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d584.s0.e0", "arg2_id": "DS.d584.s0.e1", "normalized": [] } ]
DS.d585
18642088
[ { "id": "DS.d585.s0", "type": "", "text": [ "Activation of these receptors can inhibit ACTH-release in primary cultured corticotroph adenomas and compounds that target either sst (5) (pasireotide, or SOM230) or D(2) (cabergoline) have shown significant efficacy in subsets of patients in recent clinical studies." ], "offsets": [ [ 0, 267 ] ] } ]
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[]
[]
[]
DS.d586
18642106
[ { "id": "DS.d586.s0", "type": "", "text": [ "The glutamate induced chemotaxis was accompanied by polarization of the actin cytoskeleton, and by polymerization of F-actin." ], "offsets": [ [ 0, 125 ] ] } ]
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"db_id": "P78711" }, { "db_name": "UniProt", "db_id": "P80709" }, { "db_name": "UniProt", "db_id": "P81085" }, { "db_name": "UniProt", "db_id": "P90689" }, { "db_name": "UniProt", "db_id": "P91754" }, { "db_name": "UniProt", "db_id": "Q05214" }, { "db_name": "UniProt", "db_id": "Q11212" }, { "db_name": "UniProt", "db_id": "Q24733" }, { "db_name": "UniProt", "db_id": "Q2U7A3" }, { "db_name": "UniProt", "db_id": "Q39596" }, { "db_name": "UniProt", "db_id": "Q39758" }, { "db_name": "UniProt", "db_id": "Q6TCF2" }, { "db_name": "UniProt", "db_id": "Q75D00" }, { "db_name": "UniProt", "db_id": "Q8SWN8" }, { "db_name": "UniProt", "db_id": "Q8X119" }, { "db_name": "UniProt", "db_id": "Q92192" }, { "db_name": "UniProt", "db_id": "Q92193" }, { "db_name": "UniProt", "db_id": "Q99023" }, { "db_name": "UniProt", "db_id": "Q9P4D1" }, { "db_name": "UniProt", "db_id": "Q9UVF3" }, { "db_name": "UniProt", "db_id": "Q9UVX4" }, { "db_name": "UniProt", "db_id": "Q9UVZ8" } ] } ]
[]
[]
[ { "id": "DS.d586.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d586.s0.e0", "arg2_id": "DS.d586.s0.e1", "normalized": [] } ]
DS.d587
18642386
[ { "id": "DS.d587.s0", "type": "", "text": [ "SD4 in anionic DSPG liposomes stimulated murine IL-6 production in RAW 264 cells at concentrations 25-to 30-fold lower than free drug." ], "offsets": [ [ 0, 134 ] ] } ]
[ { "id": "DS.d587.s0.e0", "type": "compound", "text": [ "SD4" ], "offsets": [ [ 0, 3 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "97663" } ] }, { "id": "DS.d587.s0.e1", "type": "protein", "text": [ "IL-6" ], "offsets": [ [ 48, 52 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O35736" }, { "db_name": "UniProt", "db_id": "P05231" }, { "db_name": "UniProt", "db_id": "P08505" }, { "db_name": "UniProt", "db_id": "P20607" }, { "db_name": "UniProt", "db_id": "P26892" }, { "db_name": "UniProt", "db_id": "P26893" }, { "db_name": "UniProt", "db_id": "P29455" }, { "db_name": "UniProt", "db_id": "P41323" }, { "db_name": "UniProt", "db_id": "P41683" }, { "db_name": "UniProt", "db_id": "P41693" }, { "db_name": "UniProt", "db_id": "P46650" }, { "db_name": "UniProt", "db_id": "P51494" }, { "db_name": "UniProt", "db_id": "P79341" }, { "db_name": "UniProt", "db_id": "Q25BC2" }, { "db_name": "UniProt", "db_id": "Q28319" }, { "db_name": "UniProt", "db_id": "Q28747" }, { "db_name": "UniProt", "db_id": "Q28819" }, { "db_name": "UniProt", "db_id": "Q2MH06" }, { "db_name": "UniProt", "db_id": "Q5I6E3" }, { "db_name": "UniProt", "db_id": "Q6V919" }, { "db_name": "UniProt", "db_id": "Q865W7" }, { "db_name": "UniProt", "db_id": "Q865X6" }, { "db_name": "UniProt", "db_id": "Q8MKH0" }, { "db_name": "UniProt", "db_id": "Q95181" }, { "db_name": "UniProt", "db_id": "Q9MZR1" }, { "db_name": "UniProt", "db_id": "Q9XT80" } ] } ]
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DS.d588
18643838
[ { "id": "DS.d588.s0", "type": "", "text": [ "To elucidate the mechanism by which rosiglitazone regulates adipose triglyceride lipase (ATGL)." ], "offsets": [ [ 0, 95 ] ] } ]
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DS.d589
18643908
[ { "id": "DS.d589.s0", "type": "", "text": [ "Rhodopsin is one of the members of the G protein-coupled receptor family that can catalyze a GDP-GTP exchange reaction on the retinal G protein transducin (Gt) upon photon absorption." ], "offsets": [ [ 0, 183 ] ] } ]
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[]
[]
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DS.d590
18644606
[ { "id": "DS.d590.s0", "type": "", "text": [ "Olanzapine was associated with a lower frequency of extrapyramidal symptoms than other antipsychotics, fewer prolactin-related adverse events than risperidone and other atypical antipsychotics, but greater weight gain than typicals and risperidone." ], "offsets": [ [ 0, 248 ] ] } ]
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[]
[]
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DS.d591
18646192
[ { "id": "DS.d591.s0", "type": "", "text": [ "In our earlier method, glutathione disulfide (GSSG) was measured by first reducing it to GSH with glutathione reductase (GR) in the presence of NADPH." ], "offsets": [ [ 0, 150 ] ] } ]
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[]
[]
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DS.d593
18647135
[ { "id": "DS.d593.s0", "type": "", "text": [ "The angiotensin-converting enzyme insertion/deletion polymorphism is associated with phagocytic NADPH oxidase-dependent superoxide generation: potential implication in hypertension." ], "offsets": [ [ 0, 181 ] ] } ]
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[]
[]
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DS.d594
18648748
[ { "id": "DS.d594.s0", "type": "", "text": [ "Administration of hesperetin to DMH treated rats significantly decreased the tumor incidence, the number of aberrant crypt foci with simultaneous enhancement of tissue lipid peroxidation, GST, GPx, SOD, and CAT activities." ], "offsets": [ [ 0, 222 ] ] } ]
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[]
[]
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DS.d595
18648826
[ { "id": "DS.d595.s0", "type": "", "text": [ "Culture of mid-segments of hair follicles in low calcium culture medium kept on agarose increased expression of filaggrin and Kdap, but downregulated expression of involucrin." ], "offsets": [ [ 0, 175 ] ] } ]
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[]
[]
[]
DS.d596
18648877
[ { "id": "DS.d596.s0", "type": "", "text": [ "The p-hydroxyphenylpyruvate produced by the Escherichia coli host was converted to HGA through the oxidation reaction of introduced HPPD." ], "offsets": [ [ 0, 137 ] ] } ]
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[]
[]
[ { "id": "DS.d596.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d596.s0.e1", "arg2_id": "DS.d596.s0.e2", "normalized": [] }, { "id": "DS.d596.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d596.s0.e0", "arg2_id": "DS.d596.s0.e2", "normalized": [] } ]
DS.d597
18649000
[ { "id": "DS.d597.s0", "type": "", "text": [ "The results showed that the intakes of dry matter (DM), organic matter (OM), nitrogen (N), the N-balance, urinary purine derivatives (PD) excretion, the ratios of allantoin to creatinine (CR), PD to CR, the plasma urea-N (PUN) and insulin increased in the animals, but the intake of neutral detergent fiber (NDF), the coefficient of whole tract, apparent digestibility of NDF, the transit time (TT) and the mean retention time (TMRT) decreased, when the proportion of concentrate in the diet increased." ], "offsets": [ [ 0, 502 ] ] } ]
[ { "id": "DS.d597.s0.e0", "type": "compound", "text": [ "nitrogen" ], "offsets": [ [ 77, 85 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "947" }, { "db_name": "PubChem", "db_id": "123329" } ] }, { "id": "DS.d597.s0.e1", "type": "compound", "text": [ "purine" ], "offsets": [ [ 114, 120 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1044" } ] }, { "id": "DS.d597.s0.e2", "type": "compound", "text": [ "allantoin" ], "offsets": [ [ 163, 172 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "204" } ] }, { "id": "DS.d597.s0.e3", "type": "compound", "text": [ "creatinine" ], "offsets": [ [ 176, 186 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "588" } ] }, { "id": "DS.d597.s0.e4", "type": "compound", "text": [ "CR" ], "offsets": [ [ 188, 190 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "23976" } ] }, { "id": "DS.d597.s0.e5", "type": "compound", "text": [ "CR" ], "offsets": [ [ 199, 201 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "23976" } ] }, { "id": "DS.d597.s0.e6", "type": "compound", "text": [ "urea" ], "offsets": [ [ 214, 218 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1176" }, { "db_name": "PubChem", "db_id": "265993" } ] }, { "id": "DS.d597.s0.e7", "type": "protein", "text": [ "insulin" ], "offsets": [ [ 231, 238 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01314" }, { "db_name": "UniProt", "db_id": "P01316" }, { "db_name": "UniProt", "db_id": "P01319" }, { "db_name": "UniProt", "db_id": "P01320" }, { "db_name": "UniProt", "db_id": "P01324" }, { "db_name": "UniProt", "db_id": "P01328" }, { "db_name": "UniProt", "db_id": "P01330" }, { "db_name": "UniProt", "db_id": "P01331" }, { "db_name": "UniProt", "db_id": "P01334" }, { "db_name": "UniProt", "db_id": "P01336" }, { "db_name": "UniProt", "db_id": "P01340" }, { "db_name": "UniProt", "db_id": "P07453" }, { "db_name": "UniProt", "db_id": "P09476" }, { "db_name": "UniProt", "db_id": "P09477" }, { "db_name": "UniProt", "db_id": "P0C236" }, { "db_name": "UniProt", "db_id": "P12703" }, { "db_name": "UniProt", "db_id": "P12704" }, { "db_name": "UniProt", "db_id": "P12708" }, { "db_name": "UniProt", "db_id": "P13190" }, { "db_name": "UniProt", "db_id": "P18109" }, { "db_name": "UniProt", "db_id": "P29335" }, { "db_name": "UniProt", "db_id": "P42633" }, { "db_name": "UniProt", "db_id": "P67968" }, { "db_name": "UniProt", "db_id": "P67969" }, { "db_name": "UniProt", "db_id": "P67971" }, { "db_name": "UniProt", "db_id": "P67973" }, { "db_name": "UniProt", "db_id": "P67974" }, { "db_name": "UniProt", "db_id": "P68243" }, { "db_name": "UniProt", "db_id": "P68245" }, { "db_name": "UniProt", "db_id": "P68987" }, { "db_name": "UniProt", "db_id": "P68988" }, { "db_name": "UniProt", "db_id": "P68989" }, { "db_name": "UniProt", "db_id": "P68990" }, { "db_name": "UniProt", "db_id": "P68991" }, { "db_name": "UniProt", "db_id": "P68992" }, { "db_name": "UniProt", "db_id": "P69046" }, { "db_name": "UniProt", "db_id": "P69047" }, { "db_name": "UniProt", "db_id": "P69048" }, { "db_name": "UniProt", "db_id": "P81423" }, { "db_name": "UniProt", "db_id": "P81881" }, { "db_name": "UniProt", "db_id": "Q9TQY7" } ] } ]
[]
[]
[]
DS.d598
18649135
[ { "id": "DS.d598.s0", "type": "", "text": [ "Activation of interleukin-6/STAT3 in rat cholangiocyte proliferation induced by lipopolysaccharide." ], "offsets": [ [ 0, 99 ] ] } ]
[ { "id": "DS.d598.s0.e0", "type": "protein", "text": [ "interleukin-6" ], "offsets": [ [ 14, 27 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P41693" } ] }, { "id": "DS.d598.s0.e1", "type": "protein", "text": [ "STAT3" ], "offsets": [ [ 28, 33 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P40763" }, { "db_name": "UniProt", "db_id": "P61635" } ] }, { "id": "DS.d598.s0.e2", "type": "compound", "text": [ "lipopolysaccharide" ], "offsets": [ [ 80, 98 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "11970143" } ] } ]
[]
[]
[ { "id": "DS.d598.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d598.s0.e2", "arg2_id": "DS.d598.s0.e1", "normalized": [] }, { "id": "DS.d598.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d598.s0.e2", "arg2_id": "DS.d598.s0.e0", "normalized": [] } ]
DS.d599
18650080
[ { "id": "DS.d599.s1", "type": "", "text": [ "To investigate the activation pathways triggered by laccase, ESR spin-trapping techniques using N-tert-butyl-alpha-phenylnitrone (PBN) as spin trap followed by ethyl acetate extraction were employed to identify and quantify the free radical intermediates." ], "offsets": [ [ 0, 255 ] ] } ]
[ { "id": "DS.d599.s1.e0", "type": "protein", "text": [ "laccase" ], "offsets": [ [ 52, 59 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q12570" } ] }, { "id": "DS.d599.s1.e1", "type": "compound", "text": [ "ethyl acetate" ], "offsets": [ [ 160, 173 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "8857" } ] } ]
[]
[]
[]
DS.d600
18650805
[ { "id": "DS.d600.s0", "type": "", "text": [ "Methylation of these CpG sites may lead to reduced OPRM1 expression in the lymphocytes of these former heroin addicts." ], "offsets": [ [ 0, 118 ] ] } ]
[ { "id": "DS.d600.s0.e0", "type": "compound", "text": [ "CpG" ], "offsets": [ [ 21, 24 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6804" } ] }, { "id": "DS.d600.s0.e1", "type": "protein", "text": [ "OPRM1" ], "offsets": [ [ 51, 56 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P35372" }, { "db_name": "UniProt", "db_id": "P79350" }, { "db_name": "UniProt", "db_id": "P97266" }, { "db_name": "UniProt", "db_id": "Q5IS39" }, { "db_name": "UniProt", "db_id": "Q5IS84" }, { "db_name": "UniProt", "db_id": "Q95247" }, { "db_name": "UniProt", "db_id": "Q95M54" }, { "db_name": "UniProt", "db_id": "Q9MYW9" } ] } ]
[]
[]
[ { "id": "DS.d600.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d600.s0.e0", "arg2_id": "DS.d600.s0.e1", "normalized": [] } ]
DS.d601
18651093
[ { "id": "DS.d601.s0", "type": "", "text": [ "Two infants with elevated serum gamma-GT had a decreased serum glutamine." ], "offsets": [ [ 0, 73 ] ] } ]
[ { "id": "DS.d601.s0.e0", "type": "protein", "text": [ "gamma-GT" ], "offsets": [ [ 32, 40 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q05902" } ] }, { "id": "DS.d601.s0.e1", "type": "compound", "text": [ "glutamine" ], "offsets": [ [ 63, 72 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "738" }, { "db_name": "PubChem", "db_id": "5961" } ] } ]
[]
[]
[ { "id": "DS.d601.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d601.s0.e1", "arg2_id": "DS.d601.s0.e0", "normalized": [] } ]
DS.d602
18651113
[ { "id": "DS.d602.s0", "type": "", "text": [ "Human bone marrow-derived mesenchymal stem cells and osteoblast differentiation on titanium with surface-grafted chitosan and immobilized bone morphogenetic protein-2." ], "offsets": [ [ 0, 167 ] ] } ]
[ { "id": "DS.d602.s0.e0", "type": "compound", "text": [ "titanium" ], "offsets": [ [ 83, 91 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "23963" } ] }, { "id": "DS.d602.s0.e1", "type": "protein", "text": [ "morphogenetic protein" ], "offsets": [ [ 143, 164 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P07580" } ] } ]
[]
[]
[]
DS.d603
18651133
[ { "id": "DS.d603.s0", "type": "", "text": [ "None of the compounds altered Cyp11b1 gene expression, indicating that 3-MeSO2-DDE inhibits CYP11B1 activity on the protein level." ], "offsets": [ [ 0, 130 ] ] } ]
[ { "id": "DS.d603.s0.e0", "type": "protein", "text": [ "Cyp11b1" ], "offsets": [ [ 30, 37 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P15393" } ] }, { "id": "DS.d603.s0.e1", "type": "compound", "text": [ "MeSO2-DDE" ], "offsets": [ [ 73, 82 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "119115" } ] }, { "id": "DS.d603.s0.e2", "type": "protein", "text": [ "CYP11B1" ], "offsets": [ [ 92, 99 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P15150" }, { "db_name": "UniProt", "db_id": "P15538" }, { "db_name": "UniProt", "db_id": "P51663" }, { "db_name": "UniProt", "db_id": "P97720" }, { "db_name": "UniProt", "db_id": "Q29527" }, { "db_name": "UniProt", "db_id": "Q29552" }, { "db_name": "UniProt", "db_id": "Q64408" } ] } ]
[]
[]
[ { "id": "DS.d603.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d603.s0.e1", "arg2_id": "DS.d603.s0.e2", "normalized": [] } ]
DS.d604
18651191
[ { "id": "DS.d604.s0", "type": "", "text": [ "Functional analysis demonstrated that elkj encoded a C20-elongase that mediated the elongation of EPA into docosapentaenoic acid (22:5n-3), confirming the two-step conversion from EPA to DHA in marine microalga." ], "offsets": [ [ 0, 211 ] ] } ]
[ { "id": "DS.d604.s0.e0", "type": "protein", "text": [ "C20" ], "offsets": [ [ 53, 56 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q9SDN0" } ] }, { "id": "DS.d604.s0.e1", "type": "compound", "text": [ "docosapentaenoic acid" ], "offsets": [ [ 107, 128 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "3145" }, { "db_name": "PubChem", "db_id": "5497182" }, { "db_name": "PubChem", "db_id": "6441454" } ] } ]
[]
[]
[ { "id": "DS.d604.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d604.s0.e1", "arg2_id": "DS.d604.s0.e0", "normalized": [] } ]
DS.d605
18651838
[ { "id": "DS.d605.s0", "type": "", "text": [ "ANP (atrial natriuretic peptide) exerts its biological effects by binding to GC (guanylate cyclase)-A/NPR (natriuretic peptide receptor)-A, which generates the second messenger cGMP." ], "offsets": [ [ 0, 182 ] ] }, { "id": "DS.d605.s1", "type": "", "text": [ "Overexpression of Ets-1 enhanced significantly Npr1 mRNA levels, protein expression, GC activity and ANP-stimulated intracellular accumulation of cGMP in transfected cells." ], "offsets": [ [ 183, 355 ] ] } ]
[ { "id": "DS.d605.s0.e0", "type": "protein", "text": [ "ANP" ], "offsets": [ [ 0, 3 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O46540" }, { "db_name": "UniProt", "db_id": "P01160" }, { "db_name": "UniProt", "db_id": "P01161" }, { "db_name": "UniProt", "db_id": "P05125" }, { "db_name": "UniProt", "db_id": "P07499" }, { "db_name": "UniProt", "db_id": "P07500" }, { "db_name": "UniProt", "db_id": "P07501" }, { "db_name": "UniProt", "db_id": "P09196" }, { "db_name": "UniProt", "db_id": "P18144" }, { "db_name": "UniProt", "db_id": "P18908" }, { "db_name": "UniProt", "db_id": "P18909" }, { "db_name": "UniProt", "db_id": "P24259" }, { "db_name": "UniProt", "db_id": "P27104" }, { "db_name": "UniProt", "db_id": "P27596" }, { "db_name": "UniProt", "db_id": "P83964" }, { "db_name": "UniProt", "db_id": "Q805D8" }, { "db_name": "UniProt", "db_id": "Q805E9" }, { "db_name": "UniProt", "db_id": "Q9GLD0" } ] }, { "id": "DS.d605.s0.e1", "type": "protein", "text": [ "atrial natriuretic peptide" ], "offsets": [ [ 5, 31 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O46540" }, { "db_name": "UniProt", "db_id": "P01160" }, { "db_name": "UniProt", "db_id": "P01161" }, { "db_name": "UniProt", "db_id": "P05125" }, { "db_name": "UniProt", "db_id": "P07499" }, { "db_name": "UniProt", "db_id": "P07500" }, { "db_name": "UniProt", "db_id": "P07501" }, { "db_name": "UniProt", "db_id": "P09196" }, { "db_name": "UniProt", "db_id": "P18144" }, { "db_name": "UniProt", "db_id": "P18908" }, { "db_name": "UniProt", "db_id": "P18909" }, { "db_name": "UniProt", "db_id": "P24259" }, { "db_name": "UniProt", "db_id": "P27104" }, { "db_name": "UniProt", "db_id": "P27596" }, { "db_name": "UniProt", "db_id": "P83964" }, { "db_name": "UniProt", "db_id": "Q805D8" }, { "db_name": "UniProt", "db_id": "Q805E9" }, { "db_name": "UniProt", "db_id": "Q9GLD0" } ] }, { "id": "DS.d605.s0.e2", "type": "protein", "text": [ "cyclase" ], "offsets": [ [ 91, 98 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O94303" }, { "db_name": "UniProt", "db_id": "P33734" }, { "db_name": "UniProt", "db_id": "Q9P4P9" }, { "db_name": "UniProt", "db_id": "Q9SZ30" } ] }, { "id": "DS.d605.s0.e3", "type": "protein", "text": [ "NPR" ], "offsets": [ [ 102, 105 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P20910" }, { "db_name": "UniProt", "db_id": "Q41249" } ] }, { "id": "DS.d605.s0.e4", "type": "protein", "text": [ "natriuretic peptide" ], "offsets": [ [ 12, 31 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P28374" } ] }, { "id": "DS.d605.s0.e5", "type": "compound", "text": [ "cGMP" ], "offsets": [ [ 177, 181 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "24316" } ] }, { "id": "DS.d605.s1.e0", "type": "protein", "text": [ "Ets-1" ], "offsets": [ [ 201, 206 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P27577" }, { "db_name": "UniProt", "db_id": "P41156" } ] }, { "id": "DS.d605.s1.e1", "type": "protein", "text": [ "Npr1" ], "offsets": [ [ 230, 234 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P18293" }, { "db_name": "UniProt", "db_id": "P18910" } ] }, { "id": "DS.d605.s1.e2", "type": "protein", "text": [ "ANP" ], "offsets": [ [ 284, 287 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O46540" }, { "db_name": "UniProt", "db_id": "P01160" }, { "db_name": "UniProt", "db_id": "P01161" }, { "db_name": "UniProt", "db_id": "P05125" }, { "db_name": "UniProt", "db_id": "P07499" }, { "db_name": "UniProt", "db_id": "P07500" }, { "db_name": "UniProt", "db_id": "P07501" }, { "db_name": "UniProt", "db_id": "P09196" }, { "db_name": "UniProt", "db_id": "P18144" }, { "db_name": "UniProt", "db_id": "P18908" }, { "db_name": "UniProt", "db_id": "P18909" }, { "db_name": "UniProt", "db_id": "P24259" }, { "db_name": "UniProt", "db_id": "P27104" }, { "db_name": "UniProt", "db_id": "P27596" }, { "db_name": "UniProt", "db_id": "P83964" }, { "db_name": "UniProt", "db_id": "Q805D8" }, { "db_name": "UniProt", "db_id": "Q805E9" }, { "db_name": "UniProt", "db_id": "Q9GLD0" } ] }, { "id": "DS.d605.s1.e3", "type": "compound", "text": [ "cGMP" ], "offsets": [ [ 329, 333 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "24316" } ] } ]
[]
[]
[ { "id": "DS.d605.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d605.s0.e5", "arg2_id": "DS.d605.s0.e2", "normalized": [] }, { "id": "DS.d605.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d605.s0.e5", "arg2_id": "DS.d605.s0.e0", "normalized": [] }, { "id": "DS.d605.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d605.s0.e5", "arg2_id": "DS.d605.s0.e3", "normalized": [] }, { "id": "DS.d605.s0.i3", "type": "compound-protein-interaction", "arg1_id": "DS.d605.s0.e5", "arg2_id": "DS.d605.s0.e4", "normalized": [] }, { "id": "DS.d605.s0.i4", "type": "compound-protein-interaction", "arg1_id": "DS.d605.s0.e5", "arg2_id": "DS.d605.s0.e1", "normalized": [] }, { "id": "DS.d605.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d605.s1.e3", "arg2_id": "DS.d605.s1.e2", "normalized": [] }, { "id": "DS.d605.s1.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d605.s1.e3", "arg2_id": "DS.d605.s1.e0", "normalized": [] } ]
DS.d606
18652538
[ { "id": "DS.d606.s0", "type": "", "text": [ "In the current study, these cells were cultured with three different media: \" BMP-plus\" medium containing dexamethasone and 100 ng/mL of rhBMP-2, \"odontogenic\" medium containing dexamethasone, and \"control\" medium without supplements." ], "offsets": [ [ 0, 234 ] ] } ]
[ { "id": "DS.d606.s0.e0", "type": "protein", "text": [ "BMP" ], "offsets": [ [ 78, 81 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P35855" } ] }, { "id": "DS.d606.s0.e1", "type": "compound", "text": [ "dexamethasone" ], "offsets": [ [ 106, 119 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5743" } ] }, { "id": "DS.d606.s0.e2", "type": "compound", "text": [ "dexamethasone" ], "offsets": [ [ 178, 191 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5743" } ] } ]
[]
[]
[]
DS.d607
18652864
[ { "id": "DS.d607.s0", "type": "", "text": [ "The allatostatins (ASTs), with a Tyr/Phe-Xaa-Phe-Gly-Leu/Ile-amide C-terminus, are neuropeptides that occur in many orders of insects, but are known to inhibit juvenile hormone (JH) synthesis by corpora allata (CA) only in cockroaches, crickets, and termites." ], "offsets": [ [ 0, 259 ] ] } ]
[ { "id": "DS.d607.s0.e0", "type": "protein", "text": [ "allatostatins" ], "offsets": [ [ 4, 17 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P42559" } ] }, { "id": "DS.d607.s0.e1", "type": "protein", "text": [ "ASTs" ], "offsets": [ [ 19, 23 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P0AE37" }, { "db_name": "UniProt", "db_id": "P0AE38" }, { "db_name": "UniProt", "db_id": "P80357" }, { "db_name": "UniProt", "db_id": "P80358" }, { "db_name": "UniProt", "db_id": "Q0TH83" }, { "db_name": "UniProt", "db_id": "Q1C8B0" }, { "db_name": "UniProt", "db_id": "Q1RB46" }, { "db_name": "UniProt", "db_id": "Q321N9" }, { "db_name": "UniProt", "db_id": "Q32G89" }, { "db_name": "UniProt", "db_id": "Q3Z294" }, { "db_name": "UniProt", "db_id": "Q5PHB9" }, { "db_name": "UniProt", "db_id": "Q66B20" }, { "db_name": "UniProt", "db_id": "Q7N2G8" }, { "db_name": "UniProt", "db_id": "Q83L52" }, { "db_name": "UniProt", "db_id": "Q8FH00" }, { "db_name": "UniProt", "db_id": "Q8Z6G0" }, { "db_name": "UniProt", "db_id": "Q8ZPV1" }, { "db_name": "UniProt", "db_id": "Q9NRA2" }, { "db_name": "UniProt", "db_id": "Q9ZC67" } ] }, { "id": "DS.d607.s0.e2", "type": "protein", "text": [ "neuropeptides" ], "offsets": [ [ 83, 96 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P21259" } ] }, { "id": "DS.d607.s0.e3", "type": "compound", "text": [ "juvenile hormone" ], "offsets": [ [ 160, 176 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6439662" } ] } ]
[]
[]
[ { "id": "DS.d607.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d607.s0.e3", "arg2_id": "DS.d607.s0.e1", "normalized": [] }, { "id": "DS.d607.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d607.s0.e3", "arg2_id": "DS.d607.s0.e0", "normalized": [] } ]
DS.d608
18652909
[ { "id": "DS.d608.s0", "type": "", "text": [ "Lecithin:retinol acyltransferase (LRAT) catalyzes the esterification of retinol (vitamin A)." ], "offsets": [ [ 0, 92 ] ] }, { "id": "DS.d608.s1", "type": "", "text": [ "Retinoic acid (RA) treatment increased this LRAT promoter-luciferase activity in PrEC cells, but not in PC-3 cells." ], "offsets": [ [ 93, 208 ] ] } ]
[ { "id": "DS.d608.s0.e1", "type": "protein", "text": [ "LRAT" ], "offsets": [ [ 34, 38 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O95237" }, { "db_name": "UniProt", "db_id": "Q9BGL2" } ] }, { "id": "DS.d608.s0.e2", "type": "compound", "text": [ "vitamin A" ], "offsets": [ [ 81, 90 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "445354" } ] }, { "id": "DS.d608.s1.e0", "type": "compound", "text": [ "Retinoic acid" ], "offsets": [ [ 93, 106 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "444795" } ] }, { "id": "DS.d608.s1.e1", "type": "protein", "text": [ "LRAT" ], "offsets": [ [ 137, 141 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O95237" }, { "db_name": "UniProt", "db_id": "Q9BGL2" } ] }, { "id": "DS.d608.s1.e2", "type": "protein", "text": [ "luciferase" ], "offsets": [ [ 151, 161 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P08659" }, { "db_name": "UniProt", "db_id": "P13129" }, { "db_name": "UniProt", "db_id": "Q01158" }, { "db_name": "UniProt", "db_id": "Q26304" }, { "db_name": "UniProt", "db_id": "Q27757" } ] } ]
[]
[]
[ { "id": "DS.d608.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d608.s0.e2", "arg2_id": "DS.d608.s0.e1", "normalized": [] }, { "id": "DS.d608.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d608.s1.e0", "arg2_id": "DS.d608.s1.e1", "normalized": [] }, { "id": "DS.d608.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d608.s1.e0", "arg2_id": "DS.d608.s1.e2", "normalized": [] } ]
DS.d609
18654608
[ { "id": "DS.d609.s0", "type": "", "text": [ "As multidrug resistance (MDR) is a major problem in the chemotherapy of progressive breast cancer, the in vitro effects of Ad-REIC treatment were investigated in terms of the sensitivity of multidrug-resistant MCF7/ADR cells to doxorubicin and of the P-glycoprotein expression." ], "offsets": [ [ 0, 277 ] ] }, { "id": "DS.d609.s1", "type": "", "text": [ "Ad-REIC treatment in MCF7/ADR cells also downregulated P-glycoprotein expresssion through JNK activation, and sensitized its drug resistance against doxorubicin." ], "offsets": [ [ 278, 439 ] ] } ]
[ { "id": "DS.d609.s0.e0", "type": "protein", "text": [ "REIC" ], "offsets": [ [ 126, 130 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q9UBP4" } ] }, { "id": "DS.d609.s0.e1", "type": "compound", "text": [ "doxorubicin" ], "offsets": [ [ 228, 239 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "31703" } ] }, { "id": "DS.d609.s0.e2", "type": "protein", "text": [ "glycoprotein" ], "offsets": [ [ 253, 265 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P08163" } ] }, { "id": "DS.d609.s1.e0", "type": "protein", "text": [ "REIC" ], "offsets": [ [ 281, 285 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q9UBP4" } ] }, { "id": "DS.d609.s1.e1", "type": "protein", "text": [ "glycoprotein" ], "offsets": [ [ 335, 347 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P08163" } ] }, { "id": "DS.d609.s1.e2", "type": "protein", "text": [ "JNK" ], "offsets": [ [ 368, 371 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P92208" }, { "db_name": "UniProt", "db_id": "Q966Y3" } ] }, { "id": "DS.d609.s1.e3", "type": "compound", "text": [ "doxorubicin" ], "offsets": [ [ 427, 438 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "31703" } ] } ]
[]
[]
[ { "id": "DS.d609.s1.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d609.s1.e3", "arg2_id": "DS.d609.s1.e0", "normalized": [] } ]
DS.d610
18654747
[ { "id": "DS.d610.s0", "type": "", "text": [ "Diflomotecan, a homocamptothecin, targets DNA topoisomerase I." ], "offsets": [ [ 0, 62 ] ] } ]
[ { "id": "DS.d610.s0.e0", "type": "compound", "text": [ "Diflomotecan" ], "offsets": [ [ 0, 12 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "219023" } ] }, { "id": "DS.d610.s0.e1", "type": "protein", "text": [ "DNA topoisomerase I" ], "offsets": [ [ 42, 61 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O27661" }, { "db_name": "UniProt", "db_id": "O28469" }, { "db_name": "UniProt", "db_id": "O34204" }, { "db_name": "UniProt", "db_id": "O51768" }, { "db_name": "UniProt", "db_id": "O58356" }, { "db_name": "UniProt", "db_id": "O66893" }, { "db_name": "UniProt", "db_id": "O69548" }, { "db_name": "UniProt", "db_id": "O73954" }, { "db_name": "UniProt", "db_id": "O83409" }, { "db_name": "UniProt", "db_id": "P04786" }, { "db_name": "UniProt", "db_id": "P06612" }, { "db_name": "UniProt", "db_id": "P07799" }, { "db_name": "UniProt", "db_id": "P0A2I1" }, { "db_name": "UniProt", "db_id": "P0A2I2" }, { "db_name": "UniProt", "db_id": "P0A620" }, { "db_name": "UniProt", "db_id": "P0A621" }, { "db_name": "UniProt", "db_id": "P11387" }, { "db_name": "UniProt", "db_id": "P16472" }, { "db_name": "UniProt", "db_id": "P30181" }, { "db_name": "UniProt", "db_id": "P30189" }, { "db_name": "UniProt", "db_id": "P32989" }, { "db_name": "UniProt", "db_id": "P34184" }, { "db_name": "UniProt", "db_id": "P34185" }, { "db_name": "UniProt", "db_id": "P39814" }, { "db_name": "UniProt", "db_id": "P40114" }, { "db_name": "UniProt", "db_id": "P41511" }, { "db_name": "UniProt", "db_id": "P41512" }, { "db_name": "UniProt", "db_id": "P43012" }, { "db_name": "UniProt", "db_id": "P46155" }, { "db_name": "UniProt", "db_id": "P46799" }, { "db_name": "UniProt", "db_id": "P47368" }, { "db_name": "UniProt", "db_id": "P55991" }, { "db_name": "UniProt", "db_id": "P57371" }, { "db_name": "UniProt", "db_id": "P68697" }, { "db_name": "UniProt", "db_id": "P68698" }, { "db_name": "UniProt", "db_id": "P73810" }, { "db_name": "UniProt", "db_id": "P78032" }, { "db_name": "UniProt", "db_id": "P93119" }, { "db_name": "UniProt", "db_id": "Q00313" }, { "db_name": "UniProt", "db_id": "Q04750" }, { "db_name": "UniProt", "db_id": "Q07050" }, { "db_name": "UniProt", "db_id": "Q59046" }, { "db_name": "UniProt", "db_id": "Q76ZS7" }, { "db_name": "UniProt", "db_id": "Q7YR26" }, { "db_name": "UniProt", "db_id": "Q87AQ6" }, { "db_name": "UniProt", "db_id": "Q8K9P7" }, { "db_name": "UniProt", "db_id": "Q92IH1" }, { "db_name": "UniProt", "db_id": "Q9CG80" }, { "db_name": "UniProt", "db_id": "Q9CN30" }, { "db_name": "UniProt", "db_id": "Q9HM08" }, { "db_name": "UniProt", "db_id": "Q9HZJ5" }, { "db_name": "UniProt", "db_id": "Q9JN65" }, { "db_name": "UniProt", "db_id": "Q9KA23" }, { "db_name": "UniProt", "db_id": "Q9KRB2" }, { "db_name": "UniProt", "db_id": "Q9PEV8" }, { "db_name": "UniProt", "db_id": "Q9PLZ2" }, { "db_name": "UniProt", "db_id": "Q9UYS8" }, { "db_name": "UniProt", "db_id": "Q9WUL0" }, { "db_name": "UniProt", "db_id": "Q9X3X7" }, { "db_name": "UniProt", "db_id": "Q9X909" }, { "db_name": "UniProt", "db_id": "Q9YB01" }, { "db_name": "UniProt", "db_id": "Q9ZDK2" }, { "db_name": "UniProt", "db_id": "Q9ZMV7" } ] } ]
[]
[]
[ { "id": "DS.d610.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d610.s0.e0", "arg2_id": "DS.d610.s0.e1", "normalized": [] } ]
DS.d611
18654835
[ { "id": "DS.d611.s0", "type": "", "text": [ "Both MudPIT and cDNA microarray analyses indicate that H2O2 treatment caused elevated levels of thioredoxin reductase 1." ], "offsets": [ [ 0, 120 ] ] } ]
[ { "id": "DS.d611.s0.e0", "type": "compound", "text": [ "H2O2" ], "offsets": [ [ 55, 59 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "784" } ] }, { "id": "DS.d611.s0.e1", "type": "protein", "text": [ "thioredoxin reductase 1" ], "offsets": [ [ 96, 119 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P29509" }, { "db_name": "UniProt", "db_id": "Q17745" }, { "db_name": "UniProt", "db_id": "Q39243" } ] } ]
[]
[]
[ { "id": "DS.d611.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d611.s0.e0", "arg2_id": "DS.d611.s0.e1", "normalized": [] } ]
DS.d612
18655070
[ { "id": "DS.d612.s0", "type": "", "text": [ "Altogether these changes offer a straightforward explanation for how following the addition of Ca(2+), the coelenterazine could escape and become available for bioluminescence on Renilla luciferase." ], "offsets": [ [ 0, 198 ] ] } ]
[ { "id": "DS.d612.s0.e0", "type": "compound", "text": [ "Ca(2" ], "offsets": [ [ 95, 99 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "271" } ] }, { "id": "DS.d612.s0.e1", "type": "compound", "text": [ "coelenterazine" ], "offsets": [ [ 107, 121 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2830" } ] }, { "id": "DS.d612.s0.e2", "type": "protein", "text": [ "luciferase" ], "offsets": [ [ 187, 197 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P08659" }, { "db_name": "UniProt", "db_id": "P13129" }, { "db_name": "UniProt", "db_id": "Q01158" }, { "db_name": "UniProt", "db_id": "Q26304" }, { "db_name": "UniProt", "db_id": "Q27757" } ] } ]
[]
[]
[ { "id": "DS.d612.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d612.s0.e1", "arg2_id": "DS.d612.s0.e2", "normalized": [] }, { "id": "DS.d612.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d612.s0.e0", "arg2_id": "DS.d612.s0.e2", "normalized": [] } ]
DS.d613
18655138
[ { "id": "DS.d613.s0", "type": "", "text": [ "The APTS functionalization was then used to immobilize bone morphogenetic protein on the bioactive glasses." ], "offsets": [ [ 0, 107 ] ] } ]
[ { "id": "DS.d613.s0.e0", "type": "compound", "text": [ "APTS" ], "offsets": [ [ 4, 8 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "4346576" } ] }, { "id": "DS.d613.s0.e1", "type": "protein", "text": [ "morphogenetic protein" ], "offsets": [ [ 60, 81 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P07580" } ] } ]
[]
[]
[ { "id": "DS.d613.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d613.s0.e0", "arg2_id": "DS.d613.s0.e1", "normalized": [] } ]
DS.d614
18655158
[ { "id": "DS.d614.s0", "type": "", "text": [ "L-Kynurenine (KYN), a tryptophan metabolite, is metabolized to kynurenic acid (KYNA), which is an antagonist of N-methyl-D-aspartate and alpha7 nicotinic acetylcholine receptors, by kynurenine aminotransferase (KAT) I and KAT II." ], "offsets": [ [ 0, 229 ] ] } ]
[ { "id": "DS.d614.s0.e0", "type": "compound", "text": [ "Kynurenine" ], "offsets": [ [ 2, 12 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "846" } ] }, { "id": "DS.d614.s0.e1", "type": "compound", "text": [ "KYN" ], "offsets": [ [ 14, 17 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "161166" } ] }, { "id": "DS.d614.s0.e2", "type": "compound", "text": [ "tryptophan" ], "offsets": [ [ 22, 32 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1148" }, { "db_name": "PubChem", "db_id": "6305" }, { "db_name": "PubChem", "db_id": "9060" }, { "db_name": "PubChem", "db_id": "5460840" } ] }, { "id": "DS.d614.s0.e3", "type": "compound", "text": [ "kynurenic acid" ], "offsets": [ [ 63, 77 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "3845" } ] }, { "id": "DS.d614.s0.e4", "type": "compound", "text": [ "KYNA" ], "offsets": [ [ 79, 83 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "3845" } ] }, { "id": "DS.d614.s0.e5", "type": "compound", "text": [ "kynurenine" ], "offsets": [ [ 182, 192 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "846" } ] }, { "id": "DS.d614.s0.e6", "type": "protein", "text": [ "KAT" ], "offsets": [ [ 211, 214 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q8NFU3" } ] }, { "id": "DS.d614.s0.e7", "type": "protein", "text": [ "KAT" ], "offsets": [ [ 222, 225 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q8NFU3" } ] } ]
[]
[]
[ { "id": "DS.d614.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d614.s0.e4", "arg2_id": "DS.d614.s0.e6", "normalized": [] }, { "id": "DS.d614.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d614.s0.e1", "arg2_id": "DS.d614.s0.e6", "normalized": [] }, { "id": "DS.d614.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d614.s0.e0", "arg2_id": "DS.d614.s0.e6", "normalized": [] }, { "id": "DS.d614.s0.i3", "type": "compound-protein-interaction", "arg1_id": "DS.d614.s0.e3", "arg2_id": "DS.d614.s0.e6", "normalized": [] }, { "id": "DS.d614.s0.i5", "type": "compound-protein-interaction", "arg1_id": "DS.d614.s0.e5", "arg2_id": "DS.d614.s0.e6", "normalized": [] } ]
DS.d615
18655176
[ { "id": "DS.d615.s0", "type": "", "text": [ "Exposure to benzo(a)pyrene (BaP) by intraperitoneal injection increased biliary BaP metabolites and liver CYP1A gene expression." ], "offsets": [ [ 0, 128 ] ] } ]
[ { "id": "DS.d615.s0.e0", "type": "compound", "text": [ "benzo(a)pyrene" ], "offsets": [ [ 12, 26 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2336" } ] }, { "id": "DS.d615.s0.e1", "type": "protein", "text": [ "CYP1A" ], "offsets": [ [ 106, 111 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q6JZS3" }, { "db_name": "UniProt", "db_id": "Q92039" }, { "db_name": "UniProt", "db_id": "Q9YH64" } ] } ]
[]
[]
[ { "id": "DS.d615.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d615.s0.e0", "arg2_id": "DS.d615.s0.e1", "normalized": [] } ]
DS.d616
18655177
[ { "id": "DS.d616.s0", "type": "", "text": [ "We examined the effect of several different doses of malathion (25, 75, 200 microM), or malathion in combination with vitamin C (VC; 10 microM) or vitamin E (VE; 30 microM), on the levels of malondialdehyde (MDA), and superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) activities in human erythrocytes in vitro." ], "offsets": [ [ 0, 337 ] ] }, { "id": "DS.d616.s1", "type": "", "text": [ "Erythrocytes were incubated under various treatment conditions (malathion alone, vitamins alone, or malathion plus vitamin) at 37 degrees C for 60 min, and the levels of MDA, and SOD, CAT and GPx activities, were determined." ], "offsets": [ [ 338, 562 ] ] }, { "id": "DS.d616.s2", "type": "", "text": [ "Treatment with malathion alone increased the levels of MDA and decreased SOD, CAT 0.05)." ], "offsets": [ [ 563, 651 ] ] } ]
[ { "id": "DS.d616.s0.e0", "type": "compound", "text": [ "malathion" ], "offsets": [ [ 53, 62 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "4004" } ] }, { "id": "DS.d616.s0.e1", "type": "compound", "text": [ "malathion" ], "offsets": [ [ 88, 97 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "4004" } ] }, { "id": "DS.d616.s0.e2", "type": "compound", "text": [ "vitamin C" ], "offsets": [ [ 118, 127 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "54670067" } ] }, { "id": "DS.d616.s0.e3", "type": "compound", "text": [ "vitamin E" ], "offsets": [ [ 147, 156 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2116" }, { "db_name": "PubChem", "db_id": "14985" }, { "db_name": "PubChem", "db_id": "1548900" }, { "db_name": "PubChem", "db_id": "1742129" } ] }, { "id": "DS.d616.s0.e4", "type": "compound", "text": [ "malondialdehyde" ], "offsets": [ [ 191, 206 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "10964" } ] }, { "id": "DS.d616.s0.e5", "type": "protein", "text": [ "superoxide dismutase" ], "offsets": [ [ 218, 238 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O50258" } ] }, { "id": "DS.d616.s0.e6", "type": "protein", "text": [ "SOD" ], "offsets": [ [ 240, 243 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O12933" }, { "db_name": "UniProt", "db_id": "O22668" }, { "db_name": "UniProt", "db_id": "O75007" }, { "db_name": "UniProt", "db_id": "P24705" }, { "db_name": "UniProt", "db_id": "P51547" }, { "db_name": "UniProt", "db_id": "P93258" }, { "db_name": "UniProt", "db_id": "Q01137" }, { "db_name": "UniProt", "db_id": "Q27666" }, { "db_name": "UniProt", "db_id": "Q9SM64" } ] }, { "id": "DS.d616.s0.e7", "type": "protein", "text": [ "catalase" ], "offsets": [ [ 246, 254 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O24339" }, { "db_name": "UniProt", "db_id": "O52762" }, { "db_name": "UniProt", "db_id": "O62839" }, { "db_name": "UniProt", "db_id": "O68146" }, { "db_name": "UniProt", "db_id": "O77229" }, { "db_name": 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"db_id": "P62577" }, { "db_name": "UniProt", "db_id": "P62578" }, { "db_name": "UniProt", "db_id": "P62579" }, { "db_name": "UniProt", "db_id": "P62580" }, { "db_name": "UniProt", "db_id": "P90682" }, { "db_name": "UniProt", "db_id": "Q00614" }, { "db_name": "UniProt", "db_id": "Q02736" }, { "db_name": "UniProt", "db_id": "Q03058" }, { "db_name": "UniProt", "db_id": "Q5RF10" }, { "db_name": "UniProt", "db_id": "Q64405" }, { "db_name": "UniProt", "db_id": "Q704S8" }, { "db_name": "UniProt", "db_id": "Q9M5L6" }, { "db_name": "UniProt", "db_id": "Q9PWF7" } ] }, { "id": "DS.d616.s0.e9", "type": "protein", "text": [ "glutathione peroxidase" ], "offsets": [ [ 266, 288 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O32770" }, { "db_name": "UniProt", "db_id": "O59858" }, { "db_name": "UniProt", "db_id": "Q00277" }, { "db_name": "UniProt", "db_id": "Q9CFV1" } ] }, { "id": "DS.d616.s1.e0", "type": "compound", "text": [ "malathion" ], "offsets": [ [ 402, 411 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "4004" } ] }, { "id": "DS.d616.s1.e1", "type": "compound", "text": [ "malathion" ], "offsets": [ [ 438, 447 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "4004" } ] }, { "id": "DS.d616.s1.e2", "type": "protein", "text": [ "SOD" ], "offsets": [ [ 517, 520 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O12933" }, { "db_name": "UniProt", "db_id": "O22668" }, { "db_name": "UniProt", "db_id": "O75007" }, { "db_name": "UniProt", "db_id": "P24705" }, { "db_name": "UniProt", "db_id": "P51547" }, { "db_name": "UniProt", "db_id": "P93258" }, { "db_name": "UniProt", "db_id": "Q01137" }, { "db_name": "UniProt", "db_id": "Q27666" }, { "db_name": "UniProt", "db_id": "Q9SM64" } ] }, { "id": "DS.d616.s1.e3", "type": "protein", "text": [ "CAT" ], "offsets": [ [ 522, 525 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O62839" }, { "db_name": "UniProt", "db_id": "O97492" }, { "db_name": "UniProt", "db_id": "P00432" }, { "db_name": "UniProt", "db_id": 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}, { "db_name": "UniProt", "db_id": "P62579" }, { "db_name": "UniProt", "db_id": "P62580" }, { "db_name": "UniProt", "db_id": "P90682" }, { "db_name": "UniProt", "db_id": "Q00614" }, { "db_name": "UniProt", "db_id": "Q02736" }, { "db_name": "UniProt", "db_id": "Q03058" }, { "db_name": "UniProt", "db_id": "Q5RF10" }, { "db_name": "UniProt", "db_id": "Q64405" }, { "db_name": "UniProt", "db_id": "Q704S8" }, { "db_name": "UniProt", "db_id": "Q9M5L6" }, { "db_name": "UniProt", "db_id": "Q9PWF7" } ] }, { "id": "DS.d616.s2.e0", "type": "compound", "text": [ "malathion" ], "offsets": [ [ 578, 587 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "4004" } ] }, { "id": "DS.d616.s2.e1", "type": "protein", "text": [ "SOD" ], "offsets": [ [ 636, 639 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O12933" }, { "db_name": "UniProt", "db_id": "O22668" }, { "db_name": "UniProt", "db_id": "O75007" }, { "db_name": "UniProt", "db_id": "P24705" }, { "db_name": "UniProt", "db_id": "P51547" }, { 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[]
[]
[ { "id": "DS.d616.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d616.s1.e0", "arg2_id": "DS.d616.s1.e3", "normalized": [] }, { "id": "DS.d616.s2.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d616.s2.e0", "arg2_id": "DS.d616.s2.e2", "normalized": [] }, { "id": "DS.d616.s2.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d616.s2.e0", "arg2_id": "DS.d616.s2.e1", "normalized": [] } ]
DS.d617
18655190
[ { "id": "DS.d617.s0", "type": "", "text": [ "Adrenomedullin reduces antioxidant defense system and enhances kidney tissue damage in cadmium and lead exposed rats." ], "offsets": [ [ 0, 117 ] ] }, { "id": "DS.d617.s1", "type": "", "text": [ "In the present study, we investigated the effect of AdM, Pb+ AdM, and Cd+ AdM treatments on superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) activities as well as the level of malondialdehyde (MDA) in the kidney." ], "offsets": [ [ 118, 361 ] ] } ]
[ { "id": "DS.d617.s0.e0", "type": "protein", "text": [ "Adrenomedullin" ], "offsets": [ [ 0, 14 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O62827" }, { "db_name": "UniProt", "db_id": "O77559" }, { "db_name": "UniProt", "db_id": "P35318" }, { "db_name": "UniProt", "db_id": "P43145" }, { "db_name": "UniProt", "db_id": "P53366" }, { "db_name": "UniProt", "db_id": "P97297" } ] }, { "id": "DS.d617.s0.e1", "type": "compound", "text": [ "cadmium" ], "offsets": [ [ 87, 94 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "23973" } ] }, { "id": "DS.d617.s1.e0", "type": "protein", "text": [ "superoxide dismutase" ], "offsets": [ [ 210, 230 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O50258" } ] }, { "id": "DS.d617.s1.e1", "type": "protein", "text": [ "SOD" ], "offsets": [ [ 232, 235 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O12933" }, { "db_name": "UniProt", "db_id": "O22668" }, { "db_name": "UniProt", "db_id": "O75007" }, { "db_name": "UniProt", "db_id": "P24705" }, { "db_name": "UniProt", "db_id": "P51547" }, { "db_name": "UniProt", "db_id": "P93258" }, { "db_name": "UniProt", "db_id": "Q01137" }, { "db_name": "UniProt", "db_id": "Q27666" }, { "db_name": "UniProt", "db_id": "Q9SM64" } ] }, { "id": "DS.d617.s1.e2", "type": "protein", "text": [ "catalase" ], "offsets": [ [ 238, 246 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O24339" }, { "db_name": "UniProt", "db_id": "O52762" }, { "db_name": "UniProt", "db_id": "O62839" }, { "db_name": "UniProt", "db_id": "O68146" }, { "db_name": "UniProt", "db_id": "O77229" }, { "db_name": "UniProt", "db_id": "O93662" }, { "db_name": "UniProt", "db_id": "O97492" }, { "db_name": "UniProt", "db_id": "P00432" }, { "db_name": "UniProt", "db_id": "P04040" }, { "db_name": "UniProt", "db_id": "P04762" }, { "db_name": "UniProt", "db_id": "P07145" }, { "db_name": "UniProt", "db_id": "P0A323" }, { "db_name": "UniProt", "db_id": "P0A324" }, { "db_name": "UniProt", "db_id": "P0A325" }, { "db_name": "UniProt", "db_id": "P0A326" }, { "db_name": "UniProt", "db_id": "P0A327" }, { "db_name": "UniProt", "db_id": "P11934" }, { "db_name": "UniProt", "db_id": "P17336" }, { "db_name": "UniProt", "db_id": "P24168" }, { "db_name": "UniProt", "db_id": "P24270" }, { "db_name": "UniProt", "db_id": "P25890" }, { "db_name": "UniProt", "db_id": "P29422" }, { "db_name": "UniProt", "db_id": "P30265" }, { "db_name": "UniProt", "db_id": "P30266" }, { "db_name": "UniProt", "db_id": "P32290" }, { "db_name": "UniProt", "db_id": "P42321" }, { "db_name": "UniProt", "db_id": "P44390" }, { "db_name": "UniProt", "db_id": "P45737" }, { "db_name": "UniProt", "db_id": "P45739" }, { "db_name": "UniProt", "db_id": "P55304" }, { "db_name": "UniProt", "db_id": "P55306" }, { "db_name": "UniProt", "db_id": "P55310" }, { "db_name": "UniProt", "db_id": "P55311" }, { "db_name": "UniProt", "db_id": "P55313" }, { "db_name": "UniProt", "db_id": "P77872" }, { "db_name": "UniProt", "db_id": "P81138" }, { "db_name": "UniProt", "db_id": "P90682" }, { "db_name": "UniProt", "db_id": "Q27710" }, { "db_name": "UniProt", "db_id": "Q49XC1" }, { "db_name": "UniProt", "db_id": "Q4L643" }, { "db_name": "UniProt", "db_id": "Q59296" }, { "db_name": "UniProt", "db_id": "Q59337" }, { "db_name": "UniProt", "db_id": "Q59602" }, { "db_name": "UniProt", "db_id": "Q59714" }, { "db_name": "UniProt", "db_id": "Q5HG86" }, { "db_name": "UniProt", "db_id": "Q5HPK8" }, { "db_name": "UniProt", "db_id": "Q5RF10" }, { "db_name": "UniProt", "db_id": "Q64405" }, { "db_name": "UniProt", "db_id": "Q6G9M4" }, { "db_name": "UniProt", "db_id": "Q6GH72" }, { "db_name": "UniProt", "db_id": "Q7A5T2" }, { "db_name": "UniProt", "db_id": "Q8CPD0" }, { "db_name": "UniProt", "db_id": "Q8FWU0" }, { "db_name": "UniProt", "db_id": "Q8NWV5" }, { "db_name": "UniProt", "db_id": "Q8X1P0" }, { "db_name": "UniProt", "db_id": "Q8Y3P9" }, { "db_name": "UniProt", "db_id": "Q926X0" }, { "db_name": "UniProt", "db_id": "Q99UE2" }, { "db_name": "UniProt", "db_id": "Q9AXH0" }, { "db_name": "UniProt", "db_id": "Q9KW19" }, { "db_name": "UniProt", "db_id": "Q9L4S1" }, { "db_name": "UniProt", "db_id": "Q9M5L6" }, { "db_name": "UniProt", "db_id": "Q9PT92" }, { "db_name": "UniProt", "db_id": "Q9PWF7" }, { "db_name": "UniProt", "db_id": "Q9Z598" }, { "db_name": "UniProt", "db_id": "Q9ZKX5" }, { "db_name": "UniProt", "db_id": "Q9ZN99" } ] }, { "id": "DS.d617.s1.e3", "type": "protein", "text": [ "CAT" ], "offsets": [ [ 248, 251 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O62839" }, { "db_name": "UniProt", "db_id": "O97492" }, { "db_name": "UniProt", "db_id": "P00432" }, { "db_name": "UniProt", "db_id": "P00485" }, { "db_name": "UniProt", "db_id": "P00486" }, { "db_name": "UniProt", "db_id": "P00487" }, { "db_name": "UniProt", "db_id": "P04040" }, { "db_name": "UniProt", "db_id": "P06135" }, { "db_name": "UniProt", "db_id": "P07641" }, { "db_name": "UniProt", "db_id": "P11504" }, { "db_name": "UniProt", "db_id": "P20074" }, { "db_name": "UniProt", "db_id": "P22782" }, { "db_name": "UniProt", "db_id": "P25309" }, { "db_name": "UniProt", "db_id": "P25819" }, { "db_name": "UniProt", "db_id": "P26825" }, { "db_name": "UniProt", "db_id": "P26826" }, { "db_name": "UniProt", "db_id": "P32796" }, { "db_name": "UniProt", "db_id": "P36882" }, { "db_name": "UniProt", "db_id": "P36883" }, { "db_name": "UniProt", "db_id": "P43155" }, { "db_name": "UniProt", "db_id": "P47934" }, { "db_name": "UniProt", "db_id": "P49417" }, { "db_name": "UniProt", "db_id": "P52826" }, { "db_name": "UniProt", "db_id": "P58777" }, { "db_name": "UniProt", "db_id": "P62577" }, { "db_name": "UniProt", "db_id": "P62578" }, { "db_name": "UniProt", "db_id": "P62579" }, { "db_name": "UniProt", "db_id": "P62580" }, { "db_name": "UniProt", "db_id": "P90682" }, { "db_name": "UniProt", "db_id": "Q00614" }, { "db_name": "UniProt", "db_id": "Q02736" }, { "db_name": "UniProt", "db_id": "Q03058" }, { "db_name": "UniProt", "db_id": "Q5RF10" }, { "db_name": "UniProt", "db_id": "Q64405" }, { "db_name": "UniProt", "db_id": "Q704S8" }, { "db_name": "UniProt", "db_id": "Q9M5L6" }, { "db_name": "UniProt", "db_id": "Q9PWF7" } ] }, { "id": "DS.d617.s1.e4", "type": "protein", "text": [ "glutathione peroxidase" ], "offsets": [ [ 258, 280 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O32770" }, { "db_name": "UniProt", "db_id": "O59858" }, { "db_name": "UniProt", "db_id": "Q00277" }, { "db_name": "UniProt", "db_id": "Q9CFV1" } ] }, { "id": "DS.d617.s1.e5", "type": "compound", "text": [ "GSH" ], "offsets": [ [ 282, 285 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "124886" } ] }, { "id": "DS.d617.s1.e6", "type": "compound", "text": [ "malondialdehyde" ], "offsets": [ [ 325, 340 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "10964" } ] } ]
[]
[]
[ { "id": "DS.d617.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d617.s0.e1", "arg2_id": "DS.d617.s0.e0", "normalized": [] } ]
DS.d618
18655797
[ { "id": "DS.d618.s0", "type": "", "text": [ "We found that Fos expression in LH orexin neurons varied in proportion to preference for morphine, cocaine or food." ], "offsets": [ [ 0, 115 ] ] }, { "id": "DS.d618.s1", "type": "", "text": [ "Recent studies showed that LH orexin neurons that project to ventral tegmental area (VTA) have greater Fos induction in association with elevated morphine preference during protracted withdrawal than non-VTA-projecting orexin neurons, indicating that the VTA is an important site of action for orexin's role in reward processing." ], "offsets": [ [ 116, 445 ] ] } ]
[ { "id": "DS.d618.s0.e0", "type": "protein", "text": [ "Fos" ], "offsets": [ [ 14, 17 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01101" }, { "db_name": "UniProt", "db_id": "P12841" }, { "db_name": "UniProt", "db_id": "Q56415" } ] }, { "id": "DS.d618.s0.e1", "type": "compound", "text": [ "morphine" ], "offsets": [ [ 89, 97 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5288826" }, { "db_name": "PubChem", "db_id": "5479215" } ] }, { "id": "DS.d618.s0.e2", "type": "compound", "text": [ "cocaine" ], "offsets": [ [ 99, 106 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2826" }, { "db_name": "PubChem", "db_id": "5760" }, { "db_name": "PubChem", "db_id": "439497" }, { "db_name": "PubChem", "db_id": "446220" }, { "db_name": "PubChem", "db_id": "644017" }, { "db_name": "PubChem", "db_id": "54613779" } ] }, { "id": "DS.d618.s1.e0", "type": "protein", "text": [ "Fos" ], "offsets": [ [ 219, 222 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01101" }, { "db_name": "UniProt", "db_id": "P12841" }, { "db_name": "UniProt", "db_id": "Q56415" } ] }, { "id": "DS.d618.s1.e1", "type": "compound", "text": [ "morphine" ], "offsets": [ [ 262, 270 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5288826" }, { "db_name": "PubChem", "db_id": "5479215" } ] } ]
[]
[]
[ { "id": "DS.d618.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d618.s0.e2", "arg2_id": "DS.d618.s0.e0", "normalized": [] }, { "id": "DS.d618.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d618.s0.e1", "arg2_id": "DS.d618.s0.e0", "normalized": [] } ]
DS.d619
18655808
[ { "id": "DS.d619.s0", "type": "", "text": [ "Cytochromes c are metalloproteins that function in electron transfer reactions and contain a heme moiety covalently attached via thioether linkages between the co-factor and a CXXCH motif in the protein." ], "offsets": [ [ 0, 203 ] ] } ]
[ { "id": "DS.d619.s0.e0", "type": "protein", "text": [ "Cytochromes c" ], "offsets": [ [ 0, 13 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O07091" }, { "db_name": "UniProt", "db_id": "O13393" }, { "db_name": "UniProt", "db_id": "O22642" }, { "db_name": "UniProt", "db_id": "O93863" }, { "db_name": "UniProt", "db_id": "P00002" }, { "db_name": "UniProt", "db_id": "P00003" }, { "db_name": "UniProt", "db_id": "P00004" }, { "db_name": "UniProt", "db_id": "P00007" }, { "db_name": "UniProt", "db_id": "P00008" }, { "db_name": "UniProt", "db_id": "P00011" }, { "db_name": "UniProt", "db_id": "P00012" }, { "db_name": "UniProt", "db_id": "P00013" }, { "db_name": "UniProt", "db_id": "P00014" }, { "db_name": "UniProt", "db_id": "P00017" }, { "db_name": "UniProt", "db_id": "P00018" }, { "db_name": "UniProt", "db_id": "P00019" }, { "db_name": "UniProt", "db_id": "P00020" }, { "db_name": "UniProt", "db_id": "P00021" }, { "db_name": "UniProt", "db_id": "P00022" }, { "db_name": "UniProt", "db_id": "P00024" }, { "db_name": "UniProt", "db_id": "P00025" }, { "db_name": "UniProt", "db_id": "P00027" }, { "db_name": "UniProt", "db_id": "P00028" }, { "db_name": "UniProt", "db_id": "P00029" }, { "db_name": "UniProt", "db_id": "P00030" }, { "db_name": "UniProt", "db_id": "P00031" }, { "db_name": "UniProt", "db_id": "P00032" }, { "db_name": "UniProt", "db_id": "P00035" }, { "db_name": "UniProt", "db_id": "P00036" }, { "db_name": "UniProt", "db_id": "P00037" }, { "db_name": "UniProt", "db_id": "P00038" }, { "db_name": "UniProt", "db_id": "P00039" }, { "db_name": "UniProt", "db_id": "P00040" }, { "db_name": "UniProt", "db_id": "P00041" }, { "db_name": "UniProt", "db_id": "P00042" }, { "db_name": "UniProt", "db_id": "P00043" }, { "db_name": "UniProt", "db_id": "P00046" }, { "db_name": "UniProt", "db_id": "P00047" }, { "db_name": "UniProt", "db_id": "P00048" }, { "db_name": "UniProt", "db_id": "P00049" }, { "db_name": "UniProt", "db_id": "P00051" }, { "db_name": "UniProt", "db_id": "P00052" }, { "db_name": "UniProt", "db_id": "P00053" }, { "db_name": "UniProt", "db_id": "P00054" }, { "db_name": "UniProt", "db_id": "P00055" }, { "db_name": "UniProt", "db_id": "P00056" }, { "db_name": "UniProt", "db_id": "P00057" }, { "db_name": "UniProt", "db_id": "P00058" }, { "db_name": "UniProt", "db_id": "P00059" }, { "db_name": "UniProt", "db_id": "P00060" }, { "db_name": "UniProt", "db_id": "P00061" }, { "db_name": "UniProt", "db_id": "P00062" }, { "db_name": "UniProt", "db_id": "P00063" }, { "db_name": "UniProt", "db_id": "P00064" }, { "db_name": "UniProt", "db_id": "P00065" }, { "db_name": "UniProt", "db_id": "P00066" }, { "db_name": "UniProt", "db_id": "P00067" }, { "db_name": "UniProt", "db_id": "P00068" }, { "db_name": "UniProt", "db_id": "P00069" }, { "db_name": "UniProt", "db_id": "P00070" }, { "db_name": "UniProt", "db_id": "P00071" }, { "db_name": "UniProt", "db_id": "P00072" }, { "db_name": "UniProt", "db_id": "P00073" }, { "db_name": "UniProt", "db_id": "P00074" }, { "db_name": "UniProt", "db_id": "P00075" }, { "db_name": "UniProt", "db_id": "P00076" }, { "db_name": "UniProt", "db_id": "P00077" }, { "db_name": "UniProt", "db_id": "P00078" }, { "db_name": "UniProt", "db_id": "P00079" }, { "db_name": "UniProt", "db_id": "P12831" }, { "db_name": "UniProt", "db_id": "P15451" }, { "db_name": "UniProt", "db_id": "P18822" }, { "db_name": "UniProt", "db_id": "P19681" }, { "db_name": "UniProt", "db_id": "P19974" }, { "db_name": "UniProt", "db_id": "P21665" }, { "db_name": "UniProt", "db_id": "P22342" }, { "db_name": "UniProt", "db_id": "P25400" }, { "db_name": "UniProt", "db_id": "P29380" }, { "db_name": "UniProt", "db_id": "P32556" }, { "db_name": "UniProt", "db_id": "P38091" }, { "db_name": "UniProt", "db_id": "P53698" }, { "db_name": "UniProt", "db_id": "P56205" }, { "db_name": "UniProt", "db_id": "P59218" }, { "db_name": "UniProt", "db_id": "P62772" }, { "db_name": "UniProt", "db_id": "P62773" }, { "db_name": "UniProt", "db_id": "P62894" }, { "db_name": "UniProt", "db_id": "P62895" }, { "db_name": "UniProt", "db_id": "P62896" }, { "db_name": "UniProt", "db_id": "P67881" }, { "db_name": "UniProt", "db_id": "P67882" }, { "db_name": "UniProt", "db_id": "P68096" }, { "db_name": "UniProt", "db_id": "P68097" }, { "db_name": "UniProt", "db_id": "P68098" }, { "db_name": "UniProt", "db_id": "P68099" }, { "db_name": "UniProt", "db_id": "P68100" }, { "db_name": "UniProt", "db_id": "P68517" }, { "db_name": "UniProt", "db_id": "P68518" }, { "db_name": "UniProt", "db_id": "P68519" }, { "db_name": "UniProt", "db_id": "P81280" }, { "db_name": "UniProt", "db_id": "P81459" }, { "db_name": "UniProt", "db_id": "P99998" }, { "db_name": "UniProt", "db_id": "P99999" }, { "db_name": "UniProt", "db_id": "Q41346" }, { "db_name": "UniProt", "db_id": "Q4HVX7" }, { "db_name": "UniProt", "db_id": "Q52V08" }, { "db_name": "UniProt", "db_id": "Q52V09" }, { "db_name": "UniProt", "db_id": "Q52V10" }, { "db_name": "UniProt", "db_id": "Q5RFH4" }, { "db_name": "UniProt", "db_id": "Q640U4" }, { "db_name": "UniProt", "db_id": "Q6C9Q0" }, { "db_name": "UniProt", "db_id": "Q6IQM2" }, { "db_name": "UniProt", "db_id": "Q6Q4H8" }, { "db_name": "UniProt", "db_id": "Q6QLW4" }, { "db_name": "UniProt", "db_id": "Q6WUX8" }, { "db_name": "UniProt", "db_id": "Q753F4" }, { "db_name": "UniProt", "db_id": "Q7YR71" }, { "db_name": "UniProt", "db_id": "Q96VP3" } ] }, { "id": "DS.d619.s0.e1", "type": "compound", "text": [ "heme" ], "offsets": [ [ 93, 97 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "4971" } ] } ]
[]
[]
[ { "id": "DS.d619.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d619.s0.e1", "arg2_id": "DS.d619.s0.e0", "normalized": [] } ]
DS.d620
18655848
[ { "id": "DS.d620.s0", "type": "", "text": [ "The antioxidant roles of selenium (Se) were evaluated in Brycon cephalus exposed to 2 mg L(-1) of Folisuper 600 BR (MP commercial formulation-MPc, 600 g L(-1)) for 96 h. Catalase (CAT), glutathione peroxidase (GPx), superoxide dismutase (SOD), glutathione S-transferase (GST), reduced glutathione (GSH) and lipid peroxidation (LPO) levels in the gills, white muscle and liver were evaluated in fish fed on diets containing 0 or 1.5 mg Se kg(-1) for 8 weeks." ], "offsets": [ [ 0, 457 ] ] }, { "id": "DS.d620.s1", "type": "", "text": [ "MPc also increased GST activity in all tissues with a concurrent decrease in GSH levels." ], "offsets": [ [ 458, 546 ] ] } ]
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