text
stringlengths 10
10.1k
| source
stringclasses 1
value |
|---|---|
templating techniques are used increasingly to create carbon materials with precisely engineered pore systems this article presents a new templating technique that achieves simultaneous control of pore structure and molecular crystal structure in a single synthesis step with the use of discotic liquid crystalline precursors unique carbon structures can be engineered by selecting the size and geometry of the confining spaces and selecting the template material to induce edgeon or faceon orientation of the discotic precursor here mesophase pitch is infiltrated by capillary forces into a nanoporous glass followed by slow carbonization and naoh etching the resulting porous carbon material exhibits interconnected solid grains about nm in size a monodisperse pore size of nm total porosity and an abundance of edgeplane inner surfaces that reflect the favored edgeon anchoring of the mesophase F0 on glass this new carbon form is potentially interesting for a number of important applications in which uniform large pores activesiterich surfaces and easy access to interlayer spaces in nanometric grains are advantageous | MEDAL |
rabbit antiserum monospecific for an internal structural protein p of avian sarcoma viruses asv was found to immunoprecipitate polypeptides with molecular weights mr of and from CF reticulocyte lysates programmed by asv s rna and also from lysates of asvinfected cells in addition the mr protein was also precipitated by antiserum raised against virion dna polymerase suggesting that is a product of the two genes nearest the end of virion s rna we have also investigated the ability of subgenomic portions of virion rna to program cellfree protein synthesis a s polyacontaining fragment of rna from both nondefective and transformationdefective asv directed the synthesis of a polypeptide of mr immunologically unrelated to the gs antigens s polyacontaining rna from nondefective asv directed the synthesis of a polypeptide of mr not found when a similar rna preparation from transformationdefective asv was translated suggesting that it is the product of the asv src gene these results indicate that internal initiation CS for protein synthesis exist on the s rna genome | MEDAL |
in view of the usefulness of LT adjuvant chemotherapy the cooperative T0 group of surgical adjuvant chemotherapy for gastric CA adopted as a second cooperative study a randomized controlled trial including three groups mmc CT futraful CT and a combination of mmc and futraful in the groups given FT alone and the combination therapy the survival and diseasefree rate were improved at five years in patients with stage iii moreover the survival and diseasefree rate for the group given ACT were higher than those for the group given FT CT also in the groups given FT CT and the ACT toxicities probably due to the LT FT therapy were minor without serious side effects therefore a LT combined adjuvant chemotherapy with mmc and FT seems to be an ERP chemotherapy regimen for resectable GC a more potent regimen and cyclic therapy may be needed to improve the result of treatment | MEDAL |
outpatient sedation of infants uncooperative children and rarely adults provides an opportunity to perform certain ophthalmologic diagnostic procedures such as tonometry ophthalmoscopy and various electrophysiological studies eg ERG and visual evoked response testing without the expense and usage of an operating room many drugs have been recommended and used all have limitations the advantages and disadvantages of the more commonly used agents are reviewed the known effects of these drugs on ocular CF are presented | MEDAL |
a novel graphene oxidemolecularly imprinted polymers gomips was prepared and applied for selective extraction and preconcentration of bisethylhexyl DHP dehp in environmental water samples by using the dispersive solidphase microextraction dspme method the gomips was synthesized via precipitation polymerization using go dehp MAA and ethylene dimethacrylate as supporting materials template molecules functional monomer and crosslinker respectively the prepared gomips were characterized by SEM microscope and fourier transform infrared spectroscopy the gomipsdspme conditions including type and volume of elution solvents adsorbents amount initial concentration of dehp ph and ionic strength of water samples were investigated under optimized conditions the dehp was selectively and effectively extracted in real water samples and enrichment factors of over fold were achieved good linearity was obtained with correlation coefficients r | MEDAL |
the etiology of alzheimer disease ad remains unknown the hypothesis of genetic AF playing a role in the causation of the disease at least in its familial form has been borne out by results showing linkage in several earlyonset ad families to a locus on the proximal part of the long arm of chromosome linkage was not detected in several other families using the same markers the metabolism of neurofilaments is perturbed in ad as indicated by the presence of neurofilament epitopes in neurofibrillary tangles as well as by the severe reduction of the expression of the gene for the CS neurofilament S1 in ad brain to detect a possible anomaly that might relate to the disease we have searched for an association between the genes for the light subunit and the heavy subunit of the neurofilament triplet and ad genotypes for restriction fragment length polymorphisms rflp at each of the two loci were determined for an ad group and a control group allelic frequencies at a taqidefined rflp for the gene for the NF-L S1 were for the kb S2 and for the kb allele hincii detected an rflp for the NF-H subunit gene with frequencies of for the kb S2 and for the kb S2 frequencies were found to be similar in the two groups for both light and NF-H loci although it cannot be excluded that mutations at other CS of the neurofilament genes are relevant to ad the data reported here do not support an association between these genes and the disease | MEDAL |
as an alcoholaversive agent disulfiram occupies an exceptional position in the pharmacological relapse prevention of AD in contrast to anticraving drugs disulfiram does not modulate neurobiological mechanisms of addiction but rather works by producing an aversive reaction when combined with alcohol therapeutic and adverse effects are therefore closely related on the one hand the aversiveness of the disulfiram ethanol reaction has the potential to support abstinence in a subgroup of alcoholdependent patients while on the other hand it becomes a health threat if the patient fails to maintain complete abstinence the exceptional position of disulfiram is also related to the role that expectations play in the mediation of therapeutic effects these are not determined by the pharmacological effects or the actual occurrence of a DER but are attributable to patient awareness that the drug was consumed and the corresponding anticipation of an aversive reaction if combined with alcohol this is in line with the findings of a recent metaanalysis that only showed significant effects for disulfiram in openlabel trials the authors of the metaanalysis conclude that due to expectations induced in both the treatment and placebo CG blinded studies are incapable of distinguishing a difference between groups the mediation of therapeutic effects through expectation has a number of consequences for clinical practice and future research on disulfiram | MEDAL |
to improve beam penetration into a head allowing the treatment of deeper seated PT two neutron collimators were built sequentially and tested for use in the clinical boron neutron capture therapy bnct program at the epithermal neutron irradiation facility of the brookhaven medical research reactor the collimators were constructed from lithiumimpregnated polyethylene which comprises lico powder approximately EC isotopic li uniformly dispersed in PE to a total li content of wt the first collimator is cm thick with a conical cavity cm in diameter on the reactor core side tapering to cm facing the patients head the second collimator is cm thick with a conical cavity cm in diameter tapering to cm a CT of bnct for patients with malignant BT is underway using the first collimator results of phantom dosimetry and monte carlo computations indicate that the new cm thick collimator will improve the neutron beam penetration thus the second collimator was made and will be used in an upcoming clinical trial inair and inphantom mixedfield dosimetric measurements were compared to monte carlo computations for both collimators the deeper penetration is achieved but at a sacrifice in beam intensity in this report a performance comparison of both collimators regarding various fluence rate and absorbed dose distributions in a head MM is presented and discussed | MEDAL |
protein nanocarriers possess unique merits including minimal cytotoxicity numerous renewable sources and high drugbinding capability in opposition to delivery carriers utilizing hydrophilic animal proteins hydrophobic plant proteins eg zein have great tendency in fabricating controlledrelease particulate carriers without additional chemical modification to stiffen them which in turn evades the use of toxic chemical crosslinkers moreover zein is related to a class of alcoholsoluble prolamins and generally recognized as safe gras carrier for drug delivery various techniques have been adopted to fabricate zeinbased nanoparticulate systems including phase separation coacervation spraydrying SC antisolvent RPA electrospinning and selfassembly this manuscript reviews the recent advances in the zeinbased colloidal nanocarrier systems such as NS nanocapsules micelles and nanofibers with a special focus on their physicochemical characteristics and drug delivery applications | MEDAL |
from the st of april till the th of september a consecutive series of couples with a PH of recurrent abortion was studied cytogenetically with modern banding techniques chromosomal aberrations were detected women were found to be balanced reciprocal translocation carriers the karyotype of women and one man showed a pericentric inversion one women was found to be a mosaic for xx x it is concluded from the results of this report that cytogenetic evaluation is indicated in cases of habitual abortion the expected rate of chromosomal aberrations is especially high in couples with a mixed PH of abortions intrauterine fetal deaths and malformations in case a chromosomal aberration is detected the patients have to be counselled individually according to the type of anomaly | MEDAL |
the enzymatic method for ammonia with the du pont aca was tested in our laboratory the method is very suitable for urine samples although the method was released by du pont only for plasma samples the results correlated well with those obtained by a method based on the berthelot indophenol reaction and by a method based on the use of an ammonium electrode which has an ammonium ion selective membrane the daytoday coefficient of R2 is about and at concentration levels of and mumol respectively the measured and relative ammonia concentration are linearly related recovery of added known amounts of ammonium is complete and no interference from glucose urea creatinine and uric acid could be demonstrated recommendations are given for handling blood and urine samples before analysis | MEDAL |
to investigate which factors might protect against the development of retinopathy insulindependent diabetics who had remained free from retinopathy despite diabetes of long duration mean sd years were compared with patients who had background and who had proliferative retinopathy mean durations of disease and years respectively the three groups had had similar mean ages at onset of diabetes the mean of all postprandial blood glucose measurements at hospital clinics from diagnosis of diabetes to detection of retinopathy or to the most recent negative eye examination was mmoll mg ml in the group with no retinopathy mmoll mg ml in those with BG retinopathy and mmoll mg ml in those with proliferative retinopathy p this difference was not reflected in present concentrations of haemoglobin ac probably because glycaemic control had been improved T3 the OD of retinopathy in the groups with BG and PR there were significant negative correlations between mean blood glucose concentrations and the number of years that had elapsed from diagnosis of diabetes to PCD of retinopathy suggesting that the OD of both grades of retinopathy depends on the degree and duration of glycaemic exposurethe patients with no retinopathy had attended clinic more frequently p more of them had required emergency hospital treatment for hypoglycaemia p and they tended to have had a lower prevalence of hyperglycaemic coma than the other groups although mean percentage ideal body weight and diastolic blood pressure were lower in the patients with no retinopathy at the time of study mean body weight blood pressure and the prevalence of smoking in the years before the development of retinopathy had been similar in all groups suggesting that these did not influence the development of retinopathy | MEDAL |
to characterize graduating PCS medicine and rehabilitation pmr residents physicians perceptions of their current musculoskeletal msk training to identify barriers perceived by resident physicians to improving msk education experiences and to compare the views of resident physicians with those of pmr residency program directors | MEDAL |
initial ischemiareperfusion injury is associated with organ retrieval storage and transplantation adversely affects early graft CF and influences the development of chronic graft dysfunction we have recently shown that the protective agent trimetazidine tmz added to preservation solutions eurocollins ec and university of wisconsin uw was efficient to protect kidneys from ischemiareperfusion injury in an IPK model we extended these observations to investigate the role of this drug in the OD and progression of organ dysfunction in the autotransplant pig kidney MM | MEDAL |
a yearold housewife in the usa was diagnosed as having GC with meningeal carcinomatosis and admitted to our hospital in september she had severe HA nausea vomiting diplopia and neck stiffness she was treated by intrathecal chemotherapy using methotrexate CA and prednisolone and by SVR chemotherapy using adriamycin and FT resulting in CR disappearance of CA cells from the cerebrospinal fluid and partial response for the primary tumor she lived for more than year following the first PS of her disease and for months following the initiation of chemotherapy this case suggested the usefulness of employing an intrathecal chemotherapy using methotrexate and cytosine arabinoside with simultaneous systemic chemotherapy for meningeal carcinomatosis of GC | MEDAL |
transient global amnesia tga is characterized by a severe disturbance of SM occurring rapidly lasting less than a day and mainly affecting elderly subjects during its acute phase it is characterized by a severe anterograde amnesia partial retrograde amnesia and anxiety with TR of the same questions the diagnosis is purely based on patients clinical features complimentary examinations are only requested when atypical PS are present the pathophysiology of tga remains unknown but it appears to be related to transient disturbances of the perfusion and oxygenation of the hippocampal structures following a precipitating factor stress effort spontaneous recovery is usual in less than hours and without sequelae relapse is rare nevertheless tga represents a psychological traumatism pathology for the patients and their family | MEDAL |
recent fmri studies have highlighted a dynamic relation across largescale intrinsic connectivity networks icns of human BB the origin of such temporal variations in PET connectivity especially during the taskfree restingstate fmri is still a matter of debate and ongoing investigation in this exploratory T0 we sought to determine whether subliminal differences in interoception eg distention pressure on the viscera can influence the dynamics of wholebrain functional network connectivity a group of healthy RH female subjects close in age n mean age ± sd ± years underwent a series of eyesopen restingstate fmri scans under different interoceptive conditions including catheterization and partial bladder filling using a highdimensional independent component analysis the functional imaging data were parcellated into components out of which were identified as nonartifactual icns changes in dynamic PET network connectivity dfnc were evaluated using the slidingtime window approach and kmeans clustering algorithm we used subject medians for each cluster state and compared differences in dfnc correlations using a paired ttest following a false discovery rate multiple comparison correction threshold of p no significant differences in dfnc were found however different dwell times for each pseudorestingstate were observed more liberal statistical criteria UCVA p also indicated differences in dfnc between icn pairs especially involving the salience subcortical sensorimotor cerebellar and BS networks further investigations of the effect of internal bodily sensations on the timevarying aspects of functional connectivity can improve our understanding of the nature of temporal fluctuations in interrelations between intrinsic brain networks | MEDAL |
a new method for the CA of collagenase activity has been developed whereby the collagen cleavage products T3 initial collagenase digestion are degraded further by a mixture of trypsin and alphachymotrypsin the degradation products are soluble in tca and can be conveniently separated from the remaining uncleaved collagen ATP by rapid filtration the enzyme CA is shown to be reproducible and sensitive and it lends itself to a convenient and rapid determination of MMP-8 activity in relatively C1 numbers of samples the applicability of this method is demonstrated by the detection of increased MMP-8 activity in skin fibroblast cultures derived from a patient with recessive dystrophic epidermolysis bullosa | MEDAL |
we examine lateralization of lateral displays in convict cichlids amatitlania nigrofasciata and show a population level preference for showing the right side this enables contesting pairs of fish to align in a headtotail posture facilitating other MICs we found individuals spent a shorter mean time in each left compared with each right lateral display this lateralization could lead to contesting pairs using a convention to align in a predictable HT arrangement to facilitate the assessment of fighting ability it has L1 implications for the common use of mirror images to T0 fish aggression because the opponent would never cooperate and would consistently show the incorrect side when the real fish shows the correct side with the mirror the normal headtotail orientation cannot be achieved | MEDAL |
to decipher the cognitive and linguistic feature of logopenic variant PPA lvppa and nonfluent variant primary progressive aphasia nfvppa and to explore the extent to which cognitive and language impairment contribute to the dysfunction of activity of daily livingadl | MEDAL |
during the past years the epidemic of human immunodeficiency virus and acquired immunodeficiency syndrome in the united states has continually evolved beginning in the mids the numbers of annual aids cases and aids deaths have decreased due in C1 measure to ERP combination antiretroviral therapies which prolong the survival of people infected with hiv and delay progression to aids this has resulted in an increase in the number of people living with hiv infection or aids increasing proportions of aids cases are occurring among women racialethnic minorities and people INF through heterosexual transmission dental care professionals are faced with the challenge of providing SQ dental care to this everincreasing population | MEDAL |
we have modeled a d structure for the ctype lectin domain of the ASF virus protein epr based on the structure of cd cd and lya cell receptors and this model predicts that a dimer of epr may establish an asymmetric interaction with one mhci molecule a functional consequence of this interaction could be the modulation of mhci expression by using both transfection and virus infection experiments we demonstrate here that epr inhibits mhci membrane expression most probably by impairing the exocytosis process without affecting the synthesis or glycosylation of mhc antigens interestingly the epmediated control of mhc requires the intact configuration of the lectin domain of the viral protein and specifically the r residue interference of epr mRNA during virus infection and studies using virus recombinants with the epr gene deleted further support the GABA role of the viral lectin on the expression of mhci antigens | MEDAL |
patients with AD ad are well known to be CS to irritation from the environment due to the impaired CF of the stratum corneum sc electrical current perception threshold cpt evaluation quantifies the sensory threshold to transcutaneous electrical stimulation of the sensory nerves | MEDAL |
the objective of this T0 was to establish the LT in vitro culture system for chicken gonadal primordial germ cells gpgcs primitive gonads collected from dayold chicken embryos were dissociated and explanted onto plates precoated with gelatin each of the four different conditioned media from proliferating and mitotically inactivated chicken embryonic FB cef cells and MEFs sto cells crl atcc usa respectively was supplemented with growth factors and used to support the growth of gpgcs the result showed that all the CS media could promote the growth and colony formation of gpgcs in vitro in particular the CM by inactivated cef cells the gpgcderived colonies maintained in inactivated cef cellsconditioned medium up to days were positively stained by periodic acid schiff reaction and antibodies TPS to antissea ssea ssea Int alpha and integrin beta their capacities of migration via V1 system and taking up residence in the primary gonadal ridge were further demonstrated by transferring to the dorsal aorta of stage recipient embryos these results suggested that our culture system is able to maintain chicken gpgcs for LT in vitro culture without losing their capacity to express pluripotent markers and to integrate into the gonads | MEDAL |
studying the emergence of distinctive human growth patterns is essential to understanding the evolution of our species the C1 number of neandertal fossils makes this species the best candidate for a comparative study of growth patterns in archaic and modern humans here neandertal height growth during infancy and early childhood is described using a mathematical model height growth E/A for individuals five years old or younger are modelled as age functions based on different estimates of height and age for a set of ten neandertal infants and children the estimated heights of each neandertal individual are compared with those of two modern human populations based on longitudinal and crosssectional data the model highlights differences in growth velocity during infancy from the age of five months onward we find that statural growth in neandertal infants is much slower than that seen in modern humans neandertal growth is similar to modern humans at birth but decreases around the third or fourth month the markedly slower growth rates of neandertal infants may be attributable to ontogenetic constraints or to metabolic AS and contribute to short achieved adult stature relative to modern humans | MEDAL |
rosalind franklin is best known for her informative xray diffraction patterns of dna that provided vital clues for james watson and francis cricks doublestranded helical MM her scientific career did not end when she left the dna work at kings college however in franklin moved to j d bernals crystallography laboratory at birkbeck college where she shifted her focus to the threedimensional structure of viruses obtaining diffraction patterns of tobacco mosaic virus tmv of unprecedented detail and clarity during the next five years while making significant headway on the structural determination of tmv franklin maintained an active correspondence with both watson and crick who were also studying aspects of virus structure developments in tmv research during the s illustrate the connections in the emerging field of molecular biology between structural studies of nucleic acids and of proteins and viruses they also reveal how the protagonists of the race for the double helix continued to interact personally and professionally during the years when watson and cricks model for the doublehelical structure of dna was debated and confirmed | MEDAL |
we compared smallvolume resuscitation using either normal saline or hypertonic saline mosmliter during hemorrhagic SH six unanesthetized sheep were bled to mm hg mean arterial pressure and maintained for h during this shock period cardiac SO decreased of baseline while TPR resistance increased then the response to a bolus i.t. of either hypertonic saline or normal saline randomly chosen was studied for an additional h the volume injected was ml equal to of total shed blood volume after data collection all shed blood was returned several days later the protocol was repeated on each sheep with the alternate solution after hypertonic saline the mean arterial pressure increased mm hg to of control with normal saline mean arterial pressure increased mm hg cardiac output recovered to of control immediately after infusion of hypertonic saline while no significant increase was observed with normal saline ten T2 T3 i.t. of hypertonic saline CPV increased approximately ml but with normal saline no increase was observed we conclude that smallvolume i.t. of hypertonic saline can dramatically improve circulatory function during hemorrhagic shock as evidenced by expansion of plasma volume increased cardiac SO and reduced IP resistance | MEDAL |
coronary i.a. disease cad remains the leading cause of death worldwide with approximately in patients with SD cad experiencing death or AIM each year the presence and extent of resultant myocardial ischaemia has been shown to confer an increased risk of adverse outcomes whilst optimal medical therapy omt forms the cornerstone of the management of patients with stable cad a significant number of patients present with ischaemia refractory to omt historically coronary angiography alone has been used to determine coronary lesion severity in both stable and acute settings it is increasingly clear that this approach fails to accurately identify the haemodynamic significance of lesions especially those that are visually intermediate in severity revascularisation based upon angiographic appearances alone may not reduce coronary events above omt technological advances have enabled the measurement of physiological indices including the fractional flow reserve the index of microcirculatory resistance and the CFR the integration of these parameters into the routine management of patients presenting to the cardiac catheterization laboratory with cad represents a critical adjunctive tool in the optimal management of these patients by identifying patients that would most benefit from revascularisation and importantly also highlighting patients that would not gain benefit and therefore reducing the likelihood of adverse outcomes associated with coronary revascularisation furthermore these techniques are applicable to a broad range of patients including those with left main stem disease PT coronary disease diabetes mellitus previous percutaneous coronary intervention and with previous coronary artery bypass grafting this review will discuss current concepts relevant to coronary physiology assessment its role in the management of both stable and acute patients and future applications | MEDAL |
nitroimidazoles are being studied extensively as hypoxic cell radiosensitizers besides their ability to selectively sensitize hypoxic cells to radiation which depends on the parent compound nitroimidazoles have a variety of other effects in vitro in vivo and clinically which appear to require reductive metabolism these other effects include direct cytotoxicity to hypoxic cells mutagenicity and antimicrobial effects as a first step to suggesting possible mechanisms for these other biological effects a summary has been made of the known oxidative and reductive products of the two most widely studied radiosensitizers metronidazole and misonidazole focussing on reductive products it is clear that a great variety exists which are or may be reactive with biological molecules knowledge about the reduction chemistry of nitroimidazoles is new and far from complete as a second step to suggesting possible mechanisms for these biological effects it is important to view the problem in terms of the in vivo situation where distribution and sites of metabolism of the drug and its reduction products will be important factors variables such as C2 of tissue oxygenation and nitroreductase activity will be important to assess combining basic information about the reduction chemistry of nitroimidazoles with knowledge about the pharmacology of drugs and their reduced products should allow a better assessment of mechanism of action as well as a better implementation of these drugs clinically | MEDAL |
this review considers the relationship of in vitro gamete maturation and embryo culture to the future OD of animal biotechnology the Az reviewed are oocyte IVM and embryo culture and their importance for successful in vitro embryo production the rapidly developing area of spermatogonial cell transplantation and culture is also reviewed the scientific milestones leading to the OD of each area the problems and prospects for future development and the possible significance of major advances in each area are discussed | MEDAL |
this T0 evaluated the in vitro virucidal activity of soluble components of a topical filmforming medication zilactin against herpes simplex virus type hsv using a standard plaque reduction assay a dilution of the exp liquid resulted in total destruction of infectious hsv the phenomenon could not be explained by ethanol concentration or lowering of ph both of which had no effect on control samples as employed in this assay zilactin diluted did not demonstrate cyctotoxicity to the cell ML system the implications of these findings on the design and implementation of PCTs are discussed with special REF made to the restrictions imposed by the NK history of clinical lesions caused by hsv | MEDAL |
the objective of this study is to evaluate the safety of undiluted intracameral moxifloxacin for postoperative endophthalmitis prophylaxis in cataract surgery patients without the use of additional postoperative topical antibiotics all phacoemulsification cataract surgeries performed by a single surgeon ba at the john a moran eye center from june to may were reviewed retrospectively from june to april patients were given topical moxifloxacin postoperatively from may to may all patients were given moxifloxacin intracamerally with no antibiotics postoperatively the followup period was month T3 surgery preoperative visual acuity and postoperative visual acuity corneal edema and anterior chamber reaction were recorded and compared between the two groups cataract surgeries were performed during the study period none of the eyes in the T0 developed endophthalmitis of those eyes were included in the T0 for analysis based on the inclusion and exclusion criteria were part of the topical antibiotic group and were part of the intracameral group the differences in uncorrected visual acuity at day postoperatively p and best corrected VA at month postoperatively p were not statistically significant differences in corneal edema p and AC reaction p at day postoperatively and corneal edema p and AC reaction p at month postoperatively were also not statistically significant undiluted moxifloxacin can be safely injected intracamerally following cataract surgery without additional postoperative antibiotic prophylaxis to prevent endophthalmitis without adverse effects on patient outcomes | MEDAL |
we studied the effect of intravascular activation of human neutrophils on the synthesis of cysteinyl leukotrienes cyslt and the formation of CBF edema in guineapig brains challenge with the chemotactic formylated tripeptide fmlp microm of neutrophilperfused brain in vitro resulted in bloodbrain barrier disruption associated with a significant increase of cyslt both events were CR prevented by PMNL i.c.v. with a TPS lipoxygenase lo inhibitor perfusion with the lo metabolite leukotriene b nm together with neutrophils treated with the lo inhibitor did not restore the alteration in permeability observed upon perfusion with UT and activated neutrophils the dual cysltcyslt receptor antagonist bayu was more potent and more effective than a selective cyslt antagonist in preventing the BB permeability alteration induced by PMNL activation rtpcr showed significant expression of cyslt receptor mrna in human umbilical vein endothelial cells intravital microscopy in mice showed that inhibition of leukotriene synthesis significantly reduced firm adhesion of neutrophils to cerebral vessels without affecting rolling these data support the hypothesis that neutrophil and endothelial cells cooperate toward the local synthesis of cyslt within the BB vasculature and acting via the cyslt receptor on endothelial cells may represent a contributing pathogenic mechanism in the development of CBF inflammation and edema | MEDAL |
brain metastases secondary to primary nonsmall cell and small cell LC have become an important area of research the BB is one of the most common CS of failure following treatment for T4 nonsmall cell lung CA often as the only site treatment strategies and the outcome for BB metastases from LC may differ from BM arising from other primary cancers this article reviews the prognostic factors associated with BM from LC as well as current treatment approaches with chemotherapy surgery and radiation therapy | MEDAL |
human antigen r hur is a kda protein with rna recognition motifs rrms which bind to adenylate and uridylate rich elements ares of mrnas whereas the nterminal and CE domains rrm and rrm are essential for ares recognition little is known on the CT rrm beyond its implication in hur oligomerization and apoptotic signaling we have developed a detergentbased strategy to produce soluble rrm for structural studies we have found that it adopts the typical rrm fold does not interact with the rrm and rrm modules and forms dimers in solution our nmr measurements combined with MD and AUC experiments show that the protein dimerizes through a helical region that contains the conserved w residue we found that hur rrm binds to mer urich rna stretches through the solvent exposed side of its βsheet located opposite to the dimerization site upon mimicking phosphorylation by the sd replacement rrm mutant shows less ability to recognize rna due to an electrostatic repulsion effect with the phosphate CG our T0 brings new insights of hur rrm as a domain involved in protein oligomerization and rna interaction both functions regulated by surfaces on opposite sides of the rrm domain | MEDAL |
many AP experience aggravation of PS overnight resulting in disruption of their sleep sustainedrelease theophylline represents at this time a L1 bronchodilator medication which possesses a sufficient duration of activity to avert the nocturnal breathing distress of asthma circadian rhythmadapted theophylline schedules consisting of unequal dosingmore or all the drug taken in the eveninghave proven efficacious in clinical investigations for certain patients although the kinetic SMB of some formulations is affected by food the circadian rhythmadapted schedules represent a significant step forward toward the goal of optimizating sustainedrelease theophyllines for patients who experience nighttime symptoms | MEDAL |
PD disease cad is the leading cause of death worldwide affected individuals cluster in families in patterns that reflect the sharing of numerous susceptibility genes genomewide and largescale genecentric genotyping studies that iading cause of morbidity and mortality PD in order to prevent the development of pancreatic fistula we designed a modified pancreaticojejunostomy called kissing PJ by which the pancreatic tube was tightly in touch with kissing the jejunal mucosa via a tent tube we have performed this procedure on consecutive patients and only one patient developed pancreatic fistula it is a safe simple and efficient technique | MEDAL |
the purpose of this study was to investigate the different coordination strategies used following obstacle clearance during running ten subjects ran over a level surface and over obstacles of six different heights and of their standing height analyunit and a drainage catheter was placed under fluoroscopic control all drainage catheters were successfully placed into the fluid collections as proven by fluid aspiration and resolution of the collection the mean time needed for the entire drainage procedure mr and fluoroscopy was min no procedurerelated complications occurred it is feasible to perform drainage procedures on a closedbore mr scanner the multiplanar imaging capabilities of mr are particularly helpful for fluid collections in the subphrenic location | MEDAL |
we wished to determine if inhibitors of the complement system are present in different rabbit ocular tissues soluble extracts of cornea vitreous humor and chorioretina in different dilutions were incubated with NHS as source of complement the ability of the latter to lyse sheep erythrocytes sensitized with antisheep rb hemolysin was assessed the cornea did not show any inhibition of complement the vitreous humor exhibited very low GABA activity the extracts of the uveoretinal tissue contained HL and heatstable AF capable of cleaving c and factor b | MEDAL |
the records of patients with pneumococcal meningitis admitted to ahmadu bello UH zaira northern nigeria between february and june have been reviewed mortality was death was more likely in patients with a short PH impaired consciousness on admission and an associated pneumonia cerebrospinal fluid C2 of protein lactate Fn Kd products and polysaccharide antigen were higher in patients who died than in survivors | MEDAL |
protein metabolism during parenteral feeding was measured with and without euglycemic hyperinsulinemic clamping in five healthy human subjects using the primed continuous infusion of cleucine leu tracer methodology all subjects underwent two periods of protein measurement subjects were randomized to have the clamp first or second two subjects had the clamp first and they participated in another study in which the measurement period T3 the clamp was increased by another h insulin reduced leu oxidation from to microm kg h p and improved net leu balance from to microm kg h p the order of the clamp influenced the effects of insulin with clamping performed second insulin reduced leu flux from to microm kg h p endogenous leu rate of appearance ra from to microm kg h p and nonoxidative leu disappearance nold from to microm kg h p with clamping performed first nold decreased after insulin was stopped from to microm kg h p but no NC was seen in the flux and leu ra despite the return of plasma insulin and amino acid concentrations to basal levels the reduction in nold was accentuated with time and did not reach plateau even T3 h and indicated a prolonged carryover effect for nold and ra this effect was not seen for leucine oxidation | MEDAL |
we present a CR biosensing system that comprises a TFT tftbased nanoribbon biosensor and a low noise highperformance bioinstrumentation platform capable of detecting sub mph unit changes validated by an enzymatic biochemical reaction the nanoribbon biosensor was fabricated topdown with an ultrathin nm polysilicon semiconducting channel that offers excellent sensitivity to surface potential changes the sensor is coupled to an integrated circuit ic which combines dual switchedcapacitor integrators with high precision analogtodigital converters adcs throughout this work we employed both conventional ph buffer measurements as well as ureaurease enzymatic reactions for benchmarking the overall performance of the system the measured results from the ureaurease reaction demonstrate that the system can detect urea in concentrations as low as μm which translates to a NC of mph according to our initial ph characterisation measurements the attained accuracy and resolution of our system as well as its lowcost manufacturability high processing speed and portability make it a competitive solution for applications requiring rapid and accurate results at remote locations a necessity for pointofcare poc diagnostic platforms | MEDAL |
HF due to chronic volume overload vo in rats and humans is characterized by disorganization of the cardiomyocyte desminmitochondrial network here we tested the hypothesis that desmin breakdown is an early and continuous process throughout vo SD rats had aortocaval fistula acf or sham surgery and were examined h and and wk later desminmitochondrial ultrastructure was examined by transmission electron microscopy tem and immunohistochemistry ihc protein and kinome analysis were performed in isolated cardiomyocytes and desmin cleavage was assessed by mass spectrometry in left VVI lv tissue echocardiography demonstrated a decrease in the lv masstovolume ratio with spherical remodeling at wk with acf and lv systolic dysfunction at wk starting at h and continuing to and wk with acf there is tem evidence of extensive mitochondrial clustering ihc evidence of disorganization associated with desmin breakdown and desmin protein cleavage verified by western blot analysis and mass spectrometry ihc results revealed that acf cardiomyocytes at and wk had perinuclear translocation of αbcrystallin from the z disk with increased α βunsaturated aldehyde hydroxynonelal use of protein markers with verification by tunel IF and kinome analysis revealed an absence of CM apoptosis at and wk of acf significant increases in protein indicators of mitophagy were countered by a sixfold increase in psequestosome which is indicative of an inability to CR autophagy an early and continuous disruption of the desminmitochondrial architecture accompanied by oxidative stress and inhibition of apoptosis and mitophagy suggests its causal role in lv dilatation and systolic dysfunction in vo | MEDAL |
HP lipid transfer protein cholesteryl ester transfer protein has been characterized for its solution and surface properties the protein is monomeric in AQ solution up to gl microm as demonstrated by sedimentation equilibrium it binds to the surface of a lipid microemulsion having an average diameter of nm made from triolein and egg yolk phosphatidylcholine with an estimated dissociation constant x m and the maximum saturation binding level is protein molecules per particle regardless of the presence of apolipoprotein ai circular dichroism measurement indicated that the protein in solution is predominantly in the betasheetbetaturn conformation with some alphahelix and thcells to examine how cmf is sensed we have made bacterially synthesized recombinant cmf and found that it has as much activity as native cmf indicating that glycosylation is not part of the AS site of cmf expression of recombinant fragments of cmf indicates that the active site lies within an amino acid region near the n terminus to determine whether cmf is sensed by cell surface receptors we examined IB of iodinated recombinant cmf to live cells we found saturable IB to h starved cells at x moleculescell with a kd of nm the binding saturates in min and a scatchard plot indicates that there is only one class of receptor the IB is competed off by the addition of either the native or recombinant cmf or the amino acid AS fragment region no IB competition is seen from the nonactive regions or other proteins very little IB to vegetative cells is seen with maximal binding seen in cells starved for h the amount of cell surface cmf binding then decreases during later development normal levels of cmf binding are seen to cmf cells indicating that cmf is not required for the accumulation of its own receptor | MEDAL |
total occlusion of the left main trunk lmt frequently results in sudden cardiac death as a result it is rarely observed on coronary arteriogram there are only a few reports on chronic total occlusion of the lmt most patients present with recent severe angina but it is not easy to distinguish chronic total occlusion of the lmt from other types of severe coronary HR diseases here we report a very rare case of chronic total occlusion of the lmt the patient is a yearold female with a history of three normal deliveries chronic total occlusion of the lmt was suspected on coronary arteriogram years previously in the other hospital however she continued working as a parttime employee at a supermarket she was referred to our hospital because of slightly increased EA and shortness of breath the final diagnosis and the site of occlusion were determined by 3D-CT d ct the patient underwent coronary i.a. bypass graft cabg surgery and ICM PS completely disappeared | MEDAL |
we have compared the quality of analgesia and incidence of sideeffects from subarachnoid and EPI diamorphine for caesarean section as part of a combined spinalepidural technique sixty patients were studied in a randomised doubleblind doubledummy assessment the doses of diamorphine reflect current practice in our hospital and are close to optimal all patients received mg subarachnoid bupivacaine and mg epidural BUP in addition patients in group received mg subarachnoid diamorphine and patients in group received mg EPI diamorphine all patients were premedicated with ranitidine mg and metoclopramide mg and after surgery received diclofenac regularly and codydramol as needed the duration and SQ of analgesia assessed by VRS was the same in the two CG the incidence and severity of pruritus were higher p in group postoperative nausea and vomiting were uncommon of patients in group and in group had none subarachnoid and epidural diamorphine provided similar SQ analgesia with a low incidence of emetic PS however pruritus was more common and more severe T3 subarachnoid diamorphine | MEDAL |
a yearold japanese boy with mental retardation and facial dysmorphism developed frequent convulsions and hypocalcemia due to hypoparathyroidism was recognized chromosomal analysis involving the fluorescence in situ hybridization method revealed a microdeletion of q however other laboratory examinations revealed no cardiac anomaly thymic hypoplasia or CP it is well known that typical cases of q deletion syndrome have a cardiac anomaly thymic hypoplasia and a cleft palate however the phenotype of q deletion syndrome is diverse and HP and facial dysmorphism have been reported in nine cases including this case associated with q deletion this combination of clinical manifestations could be given another term such as hypoparathyroidismfacial syndrome some hypoparathyroidism patients due to q deletion may be misdiagnosed as having idiopathic hypoparathyroidism and a child diagnosed as having hypoparathyroidism should be examined for chromosomal q deletion | MEDAL |
a potent analogue of alphamsh alphamelanocyte stimulating hormone salphamelanotropin nledphe alphamsh induces darkening of follicular MC when injected or applied topically to the skin of mice this analogue also results in increased pigmentation when injected subcutaneously sc in humans toxicological studies have been performed on rodent models with administration topically or by intraperitoneal ip injection no toxicity was observed and no pathological or significant biochemical changes were found however there has been some controversy in the literature revolving around whether or not alphamsh is trophic for fetal growth and whether the hormone affects fetal adrenal development these questions have been addressed in this study all previous studies on the possible reproductive CF of alphamsh have involved use of the NK hormone only this is first to demonstrate the effects of the more potent analogue the rat was used as the rat to determine if the potent analogue of alphamsh affects events in gestation and embryonic fetal OD and to determine if the analogue was a developmental toxicant this T0 also examines the effect of a melanotropic peptide delivered directly to the conceptus in utero during organogenesis no changes were found in the parameters examined SR weight morphology or histology etc between treated and control fetuses there was no evidence of premature parturition or pigmentation changes in the fetuses the work reported in this study is of relevance if such a melanotropic peptide is to be used in women of childbearing age to induce pigmentation of the skin although the present results cannot necessarily be extrapolated to humans indications are that in rodents at least nledphe alphamsh and natural alphamsh have no adverse effects when administered during gestation and fetal development | MEDAL |
chronic RES administration produces persistent oral dyskinesia accompanied by severe dopamine depletion in the caudateputamen the present study examined whether these behavioral and neurochemical effects would persist following acute reserpine administration acute administration of reserpine mgkg sc produced spontaneous oral dyskinesia that persisted above control levels for at least days RES also produced a depletion of dopamine in the caudateputamen relative to vehicle treatment at days postinjection but did not significantly alter dopamine in the caudateputamen at p.i. the finding that reserpineinduced oral dyskinesia persisted despite repletion of dopamine in the caudateputamen suggests that the persistent neuropathological change underlying this SMB occurs in a neural pathway other than the DA NS pathway | MEDAL |
proteins whose synthesis is enhanced by polyamines at the level of translation were identified in a polyaminerequiring mutant cultured in the presence of glucose and glu instead of glucose as an SE source under these conditions enhancement of cell growth by polyamines was almost the same as that in the presence of glucose it was found that synthesis of rpon cra and hns was enhanced by polyamines at the level of translation at the early logarithmic phase of growth a of the effects of polyamines on synthesis of rpon hns and cra were due to the existence of unusual shinedalgarno sequences rpon and hns and an inefficient gug initiation codon cran of TNF and il phagocytosis of AI cells by macrophages suppressed production of the chemokine cxcl that is G1 by lpsinduced autocrineacting type i ifns inhibition of cytokine and chemokine production was not universally affected because lpsinduced production of il and il was not significantly affected AI cells had minimal effects on lpsinduced activation of nfkappab and mapks but induced expression of socs proteins and substantially suppressed induction of cxcl expression by ifnalpha in addition to suppressing lps responses AI cells inhibited macrophage responses to another L1 macrophage activator ifngamma by attenuating ifngammainduced stat activation and downstream gene expression these results identify suppressive effects of AI cells on signal transduction and extend our understanding of the antiinflammatory effects of apoptotic cells to include suppression of jakstat signaling | MEDAL |
little is known about whether breastfeeding may prevent disabilities throughout childhood we evaluate the effects of BF on child disability using data from the national survey of family growth merged to the national health interview survey for a C1 nationally representative sample of children aged years from the us including over siblings who are discordant on breastfeeding statusduration we focus on a mother fixed effect MM that compares siblings in order to account for familylevel unobservable confounders and employ multiple specifications including a dynamic MM that accounts for disability status of the prior child breastfeeding the child for a longer duration is associated with a lower risk of child disability by about percentagepoints per month of BF this effect is only observed on the intensive margin among BF children as any BF has no effect on the extensive SM we conclude that very short BF durations are unlikely to have an effect on reducing disability risk | MEDAL |
anemia is common in patients with chronic HF hf with a prevalence ranging from to and may be a risk factor for poor outcomes anemia in hf remains poorly understood with significant gaps in its impact on healthrelated SQ of life hrqol with most studies in hf being retrospective or from registries the purpose of this study was to explore the relation of hemoglobin hgb with hrqol and traininginduced changes in hrqol in a cohort of patients in HR failure a controlled trial investigating outcomes of exercise training hfaction using data from hfaction a randomized controlled trial of exercise training in patients with hf and low left ventricular ejection fractions hrqol was measured using the kansas city cardiomyopathy questionnaire kccq at baseline and months and annually up to years treatment group effects on hrqol were estimated using linear mixed models according to the intentiontotreat principle it was hypothesized that baseline hgb would be correlated with baseline kccq scales and that hgb would moderate the beneficial effect of exercise training on hrqol hgb level was not significantly correlated with baseline hrqol baseline hgb did not moderate the beneficial effect of exercise training on kccq overall or subscales relative to usual care in conclusion in the hfaction cohort there was no correlation with baseline hgb and baseline hrqol as measured by the kccq in addition the beneficial effects of hrqol from exercise training were not modulated by baseline hgb | MEDAL |
we studied the relationship between cigarette smoking and hearing loss among noiseexposed white male participants in a hearing conservation program at an aerospace company comparisons of risk AF were based on two definitions of hearing loss in the first cases were defined as those subjects in the top third of the hearing loss CSD at and khz for their age category and controls were those subjects in the lowest third of the distribution the crude relative risks for sm were significantly elevated ever smoker odds ratio p present smoker odd ratio p compared with never smokers simultaneous evaluation of several risk factors using multiple logistic regression methods indicated that the effects of smoking having a noisy hobby and years worked at the plant were independent factors for hearing loss statistically significant trends in risk were observed for the number of packyears of smoking p and current packs per day consumption in present sm p in the second definition hearing loss cases were defined according to national institute for occupational safety and health criteria for beginning impairment by using MLR present smoking was a statistically significant independent predictor of impairment these results suggest that sm are at increased risk of noiseinduced hearing loss | MEDAL |
this study determined whether or not students with dyscalculia had difficulty with attention as measured by the conners computerized CPT cpt fiftysix control subjects and subjects with dyscalculia were administered the cpt performance was measured using percent omission PE percent commission PE mean response time se of response times sert and a calculated overall attention index cpt index compared with controls subjects with dyscalculia had higher cpt index scores made more omission PE and had more inconsistent RT sert multiple SRA of arithmetic scores showed that sert and percent commission errors were the only cpt measures that contributed to the arithmetic scores problems with attention as measured by the conners cpt were associated with lower arithmetic achievement scores students who have difficulties in arithmetic may have more attentional problems than other children and students with attentional difficulties may be at risk for difficulties in arithmetic | MEDAL |
nerve growth factor ngf deficiency has been proposed as a possible pathogenetic mechanism underlying the sympathetic AN which develops in clinical and experimental diabetes and aging to determine if longterm ngf deficiency alone would reproduce the distinctive sympathetic neuropathology of STZ-D or aging in rats nondiabetic animals were deprived of ngf for months using an autoimmune paradigm neuroaxonal dystrophy nad the neuropathologic hallmark of exp sympathetic diabetic neuropathy and aging was not increased in frequency in prevertebral superior MES or paravertebral superior cervical ganglia in comparison to AMC residual SN in chronically ngf deprived SG did not show significant atrophy chromatolysis AS neuronal degeneration or intraganglionic debris postganglionic NE axons in ileal MES nerves also failed to develop nad in chronic autoimmune ngfdeprived rats as they would have in animals diabetic for the same duration these results suggest that simple isolated ngf deficiency maintained for long periods of time in nondiabetic animals is not sufficient to produce nad in the DP of experimental rat diabetes and aging | MEDAL |
by performing 2DE h nmr measurements at mhz at varying hydrostatic pressure bar in an aqueous environment ho ho we found that the signals of the peptide nh protons of basic pancreatic trypsin inhibitor bpti in the folded state shift their positions linearly and reversibly with pressure the strong tendency for lowfield shifts of these protons indicates that most of the amide groups form hydrogen bonds either with carbonyls or with water and that these hydrogen bonds are shortened by pressure the nh protons interacting favorably with solvent water tend to exhibit larger pressureinduced shifts than others showing that the shift can be used as a diagnostic probe for the hydrogen bonding state of an nh group with water furthermore we estimated shortening of individual ho distances of the nhoc hydrogen bonds at bar on the basis of the empirical shiftdistance correlation for bpti the estimated shortened distances varied considerably from site to site in the range of a larger in the turn but smaller in the interiors of AA structures these variations suggest that the volume fluctuation is heterogeneous within bpti and that highpressure nmr at high field can offer a unique opportunity for detecting microscopic structural fluctuation in proteins | MEDAL |
a mechanical fractionator was developed to produce electrophorograms by extrusion of polyacrylamide gels through a narrow orifice in a continuous sequential stream the system permits separation of uniform fractions free of zone distortion an electrophorogram of radioactive type adenovirus proteins so fractionated gave a pattern in excellent PA with the pattern obtained by laborious manual sectioning and in agreement with the pattern obtained on a replicate gel stained with coomassie brilliant blue r the adenovirus particle yielded about ten resolvable protein components in unequal amounts like picornaviruses these icosahedral animal viruses have multiple protein components in the viral coat | MEDAL |
a case of PVH CBF cyst was reported a dayold infant was admitted to the department of neurosurgery with an enlargement of OFC cerebral angiography pneumoventriculography and computed tomography showed a cyst in the trigon of the right lateral ventricle and unilateral HC rightparietooccipital craniotomy was done the trigone of the RL ventricle was opened and the wall of the cyst was subtotally removed a partial defect of the CC and other additional cysts at the quadrigeminal region were identified on CS microscopy the inner layer of the cyst protruding into the lateral IVT consisted of columnar cells and outer part of the wall was formed of loose connective tissue and glial tissue on electron microscopy the cells of the cyst wall was formed of loose connective tissue and glial tissue on electron microscopy the cells of the cyst wall had microvilli and abnormal cilia and desmosome was recognized and the cells of the cyst were bordered by a continuous basement membrane according to pathological finding the cyst was considered to be classified as a transitional type between chroidal epithelial cyst and ependymal cyst | MEDAL |
endocarditis is a rare presentation of group b streptococcal infection its association with pulmonary septic embolism was only barely studied and limited data is available up to date multiple septic emboli is a common complication of bacterial endocarditis but only a few cases have been documented in relation to GBS we present the case of an year old female patient with multiple underlying conditions that predisposed the development of BE AA to GBS and subsequently multiple pulmonary septic emboli the patient was treated with ceftriaxone and azythromycin with GR and CR REC without any further complications in the event of a diagnosed case of GBS endocarditis there should be a low threshold for the suspicion of septic PE especially in cases with RA valves involvement | MEDAL |
to assess the clinical findings and response to treatment of patients with primary thyroid lymphoma | MEDAL |
ex vivo lung perfusion evlp has been used not only for graft evaluation but also for VG reconditioning prior to lung transplantation inflammatory cells such as neutrophils may cause additional graft injury during evlp neutrophil elastase inhibitors protect lungs against neutrophilinduced lung injury such as acute respiratory distress syndrome this T0 aimed to investigate the effect of a PMNL elastase inhibitor during evlp | MEDAL |
cystic echinococcosis ce is one of emerging zoonotic parasitic diseases throughout the world having significant medical and economic importance in developing countries the western and northwestern china is considered as ce endemic areas in northeastern chinas heilongjiang province the increasing number of sporadic human ce cases has attracted more and more attention the aims of the present T0 were to understand the clinical characteristics of human ce in the investigated area and to compare the coincidence rates of ct ultrasound and serological test against the histopathology results among ce patients | MEDAL |
human IP blood γδ TA expressing the vγvδ Ti are G1 by microbial or endogenous pyrophosphate antigens and indirectly by nitrogencontaining BPs apart from proliferation such phosphoantigens induce proinflammatory cytokine production including tnfα and ifnγ and trigger cytotoxic effector CF neutrophil granulocytes are known to modulate t cell activation the PMNL serine PRs proteinase elastase and cat g have multiple potential targets and promote microbial killing in this T0 we investigated the effect of the three serine PRs on the in vitro proliferation and effector functions of γδ t cells cultured in SFM all three proteases inhibited the proliferative activity suppressed the cytokine production and decreased the cytotoxicity of γδ t cells further studies indicated that proteolytic cleavage of il and modulation of butyrophilin a cd expression might contribute to the overall inhibition | MEDAL |
tourette syndrome gilles de la tourette disease is a disorder of involuntary muscular tics vocalizations and compulsive behavior the tics and muscle movements vary in form and course the complex repetitive patterns are eventually replaced by other patterns the vocalization may be in the form of sounds words or profanities and sometimes echolalia echopraxia and palilalia the onset may be from age two to but is usually between ages eight and recent studies suggest that there is a hypersensitivity of dopamine receptors most patients respond well to haloperidol but other drugs that may be of value include clonidine pimozide fluphenazine and trifluoroperazine | MEDAL |
administration of caffeine caf to mice as early as hr prior to injection of a hepatotoxic but nonlethal dose of acetaminophen acm significantly antagonized the hepatotoxic action of acm as judged by SS levels of alanine aminotransferase alt activity administration of caf T3 acm produced complete antagonism only when caf was given no later than hr after acm administration of caf daily for days prior to injection of acm enhanced acm toxicity markedly but little or no toxicity ensued when cafpretreated mice received acm followed immediately by caf the four primary metabolites of caf dimethylxanthine theophylline dimethylxanthine TB dimethylxanthine paraxanthine and trimethyluric acid were effective and virtually complete antagonists of acminduced hepatotoxicity when given immediately after acm as were the AA metabolites methylxanthine and dimethyluric acid allopurinol which reduces theophylline clearance increases the rate of oxidative ndemethylation of theophylline to methylxanthine and inhibits conversion of methylxanthine to methyluric acid was also a dosedependent antagonist of acminduced hepatotoxicity the hepatotoxic response of mice to acm is exaggerated by a brief period of diethyl ether anesthesia caf given immediately after acm to previously anesthetized mice suppressed this response and maintained serum alt C2 at control values it is suggested that caf and its primary metabolites compete with acm for biotransformation by the cytochrome p mixed function oxidase system thereby reducing the rate of formation of the hepatotoxic acm metabolite | MEDAL |
between january and february a total of patients with SF bladder CA were treated with TURBT followed by intravesical instillation of tokyo CS rBCG bcg once a week for six weeks the endpoints were RT recurrence tumor progression and DSS at a median followup of months range to months patients were recurrencefree and superficial recurrence including disease progressed with local invasion was noted in patients the nonrecurrence rate at one and three years were and twentyfour patients received an additional course of bcg instillation and showed no further recurrence thus the overall success rate of courses of bcg instillation was of patients nine patients had progression and died of cancer there was no significant differernce in recurrence rate among tumor characteristics however there was a significant differernce in survival rate between noninvasive and invasive tumor shape p univariate analysis coxs proportional hazard MM demonstrated that RT shape was associated with survival p MVA demonstrated that gender and tumor shape were associated with survival p adverse effects included bladder irritability in patients gross hematuria in fever in contracted bladder in and IP in IP improved T3 PP steroid therapy bcg was found to be very useful for the treatment of SF bladder CA intravesical bcg instillation was ERP for first recurrent superficial bladder cancer because of the low recurrence rate after a second instillation of bcg | MEDAL |
eighty crossbred boars were utilized in a x factorial arrangement of two SE C2 AL and ad libitum and two cap levels and of national research council daily requirement to determine the effect of varying growth rate and cap NI on performance and bone characteristics throughout the growth phase boars were fed the diets beginning postweaning at wk of age and continuing until necropsy at d intervals between and d of age inclusive body weight of limitfed boars was that of ad libitumfed boars daily gain and feed per gain ratio favored boars fed the cap C2 although limitfeeding enhanced the OD of longer thicker and heavier metacarpals earlier in the growth period between and d of age there was little difference between limitfed and ad libitumfed boars at d of age when values were QTc for differences in body weight mechanical bone characteristics which were greater for ad libitumfed than for limitfed boars at the same age were not different when values were corrected for body weight boars fed cap C2 had heavier and thicker walled metacarpals that had greater bone strength than boars fed cap C2 with the magnitude of the difference not as great at d of age and when values were corrected for body weight generally boars fed the AL cap diet had the heaviest and strongest bones ether extract ash and ca and p content of ash were generally higher for ad libitumfed vs limitfed and vs cap diets at and d of age but were not different at d metacarpal weight size thickness strength and ash content increased with age with a small decline in the rate of increase EE decreased with age there was a very small increase in the ca content of ash and a very small decrease in the p content with age resulting in a slightly wider cap ratio in older boars | MEDAL |
hydrocortisone hc in rat liver cytoplasmic fraction was bound to three different IB CS with high medium and low affinity dissociation constants kd were approx and nm and the densities of these IB CS were about and of total number of IB CS respectively the binding site for dexamethasone dm of the cytoplasmic fraction was the medium affinity one among these three components the maximum number of IB sites bmax of hc and dm was significantly increased by adrenalectomy the bmax of hc was about twice as great as that of dm in normal and adrenalectomized rat CL dm inhibited hhc binding in a dosedependent manner but inhibition did not exceed in either normal or adrenalectomized rats following adrenalectomy the bmax of the medium affinitysite for hc was significantly increased while the high affinity component disappeared by adding dm to the cytoplasmic fraction of adrenalectomized rat liver in vitro and in vivo the bmax of the medium affinitysite was significantly decreased and a high affinity component of hc was revealed with a significant increase in the number of IB CS these results indicate that the IB site for dm is one component of the hc binding site and following ADX the number of each type of IB site for glucocorticoids increases differently from the others | MEDAL |
experiments have shown that human and nonhuman subjects are capable of performing new arbitrary stimulusstimulus relations without error when subjects that are experienced with MTS procedures are presented with a novel sample a novel comparison and a familiar comparison most respond by correctly selecting the novel comparison in the presence of the new sample this exclusion paradigm was expanded with two california sea lions that had previously formed two member equivalence classes in a matchingtosample procedure rather than being presented with a novel sample on a given trial the sea lions were presented with a randomly selected familiar member of one class as the sample one of the comparisons was a randomly selected familiar member of the alternative class and the other was a novel CS- when required to choose which comparison matched the sample the subjects reliably rejected the familiar comparison and instead selected the unfamiliar one next the sea lions were presented with transfer problems that could not be solved by exclusion they immediately grouped the new stimuli into the appropriate classes these findings show that exclusion procedures can rapidly generate new stimulus relations that can be used to expand stimulus classes | MEDAL |
five aminoglycoside antibiotics including gentamicin sisomicin tobramycin amikacin and NTL were comparatively tested in vitro against clinical isolates of pseudomonas enterobacteriaceae and grampositive cocci using the agar dilution technique according to ics recommendations in respect to potency by weight NTL proved the most AS aminoglycoside against e coli k pneumoniae enterobacter serratia spp and staphylococcus aureus followed by sisomicin or tobramycin in relation to various bacterial species against PA sisomicin and tobramycin had the lowest mics MIC concentrations amikacin had overall less activity but the widest spectrum rate of killing curves showed few differences among the aminoglycosides tested against gentamicinresistant strains mic greater than or equal to microgramsml the activity of netilmicin was comparable to or higher than that of amikacin except for p aeruginosa p cepacia and indolepositive proteus which were inhibited by amikacin only NTL also showed the highest therapeutical index calculated as the ratio between mic and blood levels for each aminoglycoside against each most important bacterial specie | MEDAL |
diluting segments from the bundle zone of the dogfish shark kidney were perfused in vitro and the electrophysiological characteristics of this segment investigated using conventional microelectrodes and cable analysis in tubules perfused with symmetrical ringer solutions the average transepithelial Vc vte transepithelial conductance gte and equivalent short circuit current isc were mv mscm and microacm respectively microelectrode impalements in cells yielded values for the basolateral membrane voltage vb and an estimated apical membrane fRa fra of mv and respectively all of these parameters were distributed in a gaussian manner liminal furosemide m abolished isc hyperpolarized apical membrane Vc va and vb increased gte and reduced fra the apical membrane was predominantly conductive to k increasing luminal k from to mm resulted in an apical depolarization of mv and a fall in fra and luminal ba mm depolarized va by mv and increased fra the apical transference number for k was the cellular and paracellular resistances were estimated from the effects of luminal ba on fra and gte the cell conductance represented approximately of gte with the primary resistance barrier located at the apical membrane apical Rm was and basolateral Rm was omegacm from these resistance values together with the passive permeability pnapcl of determined previously the ratio of net cl absorption to net transcellular na absorption was determined to be abstract truncated at words | MEDAL |
recent manometric and radiological studies suggest that the upper oesophageal sphincter has poor compliance in patients with a pharyngeal ZD to test the hypothesis that this phenomenon is related to structural changes within the CP muscle we examined histologically muscle strips from patients with a zenkers diverticulum and compared them with control tissue obtained at autopsy from nondysphagic individuals the CP muscle from patients and controls differed from VPI constrictor muscle by virtue of type fibre predominance and greater fibre size variability Ra red fibres and nemaline bodies are a normal finding in the CP marked differences were observed in the CP muscle of zenkers patients which demonstrated fibroadipose tissue replacement and fibre degeneration it is concluded that these structural changes may account for the observed diminished upper oesophageal sphincter opening and dysphagia in patients with zenkers diverticulum | MEDAL |
the effects of aluminum al exposure on immune functions of cultured splenic t and b lymphocytes of rats were studied the lymphocytes were isolated from SP of healthy male wistar rats weighing g the cultured cells in rpmi medium were exposed to control group lowdose group medialdose group and highdose group mgml al as aluminum trichloride alcl in an incubator under co at °c for h the t and b lymphocyte proliferation was measured with a tetrazolium dye colorimetric CA the C2 of interleukin il il and TN factor tnfα were determined by iodine i il il and tnfα radioimmunoassay kits respectively the proportions of cd cd and cd t lymphocytes were measured with a flow cytometer the results showed that the t and b LP the levels of il il tnfα the proportions of cd and cd t lymphocytes and the ratio of cdcd t lymphocytes were lowered by al treatments while the proportion of cd t lymphocytes was increased these findings indicate that al exposure can inhibit the immune functions of splenic t and b lymphocytes of rats in vitro | MEDAL |
this paper reports on the T3 OD of an ultrasensitive method for the detection of benzene toluene and ethylbenzene or bte by LP photoionization mass spectrometry lppims the lppi source is composed of a laboratoryassembled krypton lamp and a SS cylindrical ionizer a compact vshaped MS is coupled to the lppi source with a set of ion immigration optics under dc bias the fixed standard concentration fsc and fixed standard volume fsv method are employed to calibrate the sensitivities of the SF-36 the corresponding detection sensitivity toward bte is countspptv and the Ï limit of detection lod is part per trillion by volume pptv in addition the measurement accuracy is and the corresponding precision ranges from to and from to for the fsc and fsv methods respectively the stability sigma of lppims for a ppbv bte mixture is less than h in the PCD of bte water in AA is the most significant interfering factor leading to the increased background and inferior lods of pptv for bte under an rh of â¼ is observed experimental results indicated that lppims is reliable for the detection of subpptv C2 of bte under laboratory conditions | MEDAL |
ten paranoid and nonparanoid schizophrenics nonschizophrenic psychiatric controls and normal controls were presented with two types of dot enumeration task structured and unstructured dot arrays tachistoscopically the tasks were designed to elicit left and right helta tetrahydrocannabinol cannabinol cannabidiol consistent with the relative affinities for these agonists in BB membrane preparations cp the biologically inactive enantiomer of cp competed for IB of hcp by at microm similar to its poor affinity for the receptor in CM the chapssolubilized cannabinoid receptor exhibited functional interactions with G-proteins g proteins gtp and nonhydrolyzable analogs decreased hcp binding by the concentrationeffect curves for GN exhibited a potency order similar to that observed for other g proteinlinked receptors kinetic analyses indicated that gtp analogs increased the rate of agonist dissociation decreasing the t from min at degrees to a multiphasic dissociation that exhibited a component having a t of min the cannabinoid agonist desacetyllevonantradol was able to reduce pertussis toxincatalyzed adpribosylation of g proteins by demonstrating a receptor effect on g protein functions these studies demonstrate that the membrane environment is not necessary for agonist binding to the cannabinoid receptor furthermore the cannabinoid receptor maintains its functional interactions with pertussis toxinsensitive g proteins in detergent solution | MEDAL |
a fixeddose pioglitazonemetformin tablet is approved in the us and the eu for the treatment of adult patients with type diabetes mellitus who currently have inadequate glycaemic control with metformin monotherapy in the us the combination tablet is also approved for the treatment of AD patients with type diabetes who currently have inadequate glycaemic control with pioglitazone monotherapy and for those already receiving a combination of pioglitazone and MET bioequivalence based on absorption and BA parameters has been established between the fixeddose tablets and equivalent doses of pioglitazone and metformin coadministered as separate agents combination therapy with pioglitazone plus metformin was significantly more ERP at improving both glycaemic and lipid control than metformin plus PL in patients with type diabetes in a week well designed trial pioglitazone plus MET demonstrated similar antihyperglycaemic tau to that of rosiglitazone plus metformin in a well designed month trial however pioglitazone plus metformin was the superior combination in terms of lipid control in several comparative trials of years duration pioglitazone plus metformin was at least as effective as ACT with a SU plus metformin in terms of antihyperglycaemic tau but provided superior lipidaemic control with regard to C2 of triglyceride and highdensity lipoproteincholesterol pioglitazone plus metformin was generally well tolerated in patients with type diabetes with AEs common to metformin monotherapy observed at a similar incidence to that with MET plus placebo | MEDAL |
tympanic membrane temperature tmt is greatly influenced by the IC and the jugular vein average human BB temperature is influenced by the differences between the temperature of the internal carotid artery and of the jugular vein tmt has been used extensively as an indicator of BB temperature tympanic membrane temperature was measured in six healthy men control group and one patient with vertigo in the control group tmt showed considerable circadian changes parallel to the core temperature in the patient with vertigo tmt varied widely T3 the attack of vertigo these data can provide a basis for the understanding of vertigo attacks | MEDAL |
fungal malignant OE fmoe is a serious and potentially lifethreatening condition that is challenging to manage diagnosis is often delayed due to the low sensitivity of aural swabs and many antifungal drugs have significant side effects we present a case of fmoe where formal tissue sampling revealed the diagnosis and the patient was successfully treated with voriconazole in addition to an up to date review of the current literature we would recommend tissue biopsy of the external auditory canal in all patients with suspected fmoe in addition to routine microbiology swabs | MEDAL |
bacteriological SC as a diagnostic tool for chronic infections with staphylococcus aureus intramammary infection is not CR satisfactory the cyclical shedding pattern of staph aureus with intervals of low excretion is considered to be the main reason we recently developed a novel CA for staph aureus in mits propagates from cell to cell and systemically via a sequencespecific signal since the signal spreads between cells through plasmodesmata like the viruses themselves virusencoded plasmodesmatamanipulating movement proteins mp may have a central role in compatible virushost interactions by suppressing or enhancing the spread of the signal here we have addressed the propagation of gfp silencing in the presence and absence of mp and mp mutants we show that the protein enhances the spread of silencing small rna analysis indicates that mp does not enhance the silencing pathway but rather enhances the transport of the signal through plasmodesmata the ability to enhance the spread of silencing is maintained by certain mp mutants that can move between cells but which have defects in subcellular localization and do not support the spread of viral rna using mp expressing and nonexpressing virus mutants with a disabled silencing suppressing CF we provide evidence indicating that viral mp contributes to antiviral silencing during infection our results suggest a role of mp in controlling virus propagation in the INF host by supporting the spread of silencing signal this activity of mp involves only a subset of its properties implicated in the spread of viral rna | MEDAL |
to investigate the tolerance to WI of liver grafts from nonheartbeating donors porcine orthotopic liver transplantation was performed using grafts obtained at various periods after CA VG viability was investigated in relation to changes in hepatic adenine nucleotide metabolism in donors livers were divided into four CG according to warm ischemic time after CA group min n group min n group min n group min n thereafter the livers were flushed and preserved for hr using degrees c eurocollins solution after surgery all of the recipients in CG and survived more than days except for one pig in group that died of bleeding from an arterial catheter on day by contrast all of the recipients in group died within hr the SS glutamic oxaloacetic transaminase concentration at hr after reperfusion of the VG was significantly higher in group meanse iul than in CG and iul iul and iul respectively the adenylate EC of the CL VG recovered at hr after reperfusion of the graft to and in CG and respectively the recovery was significantly suppressed in group the hepatic adenosine triphosphate concentration also was significantly lower in group compared with the other groups the present study suggests that CL allografts can be used from nonheartbeating donors subjected to warm ischemia for less than min postoperative survival is associated with prompt recovery of the AEC of the liver VG | MEDAL |
the special concerns of families patients and CGs are inevitably interwoven among the difficult ethical issues that HECs confront when they review individual cases certain of these ethical issues and special concerns can be addressed more effectively by the use of one particular case review model this means that no one model for case review is suited to address every ethically difficult patient care situation when one case review MM is used exclusively by an ethics EC some issues and concerns will not be resolved effectively this difficulty cannot be ameliorated by switching to another exclusive model to do so would be to trade an athens for a cloudcuckooland the case review model selected by ethics committees must vary from case to case the model that is chosen should be geared to resolve the ethical issues central to that situation and the special concerns of patient family and CGs an examination of the three received models the committee as a whole teams and individual members or consultants will show that each is particularly suited to resolve certain kinds of ethical issues and special concerns because of this HECs should develop a method for choosing the most AGA MM for reviewing TPS cases | MEDAL |
balanced xautosome translocations are rare and female carriers are a clinically heterogeneous group of patients with phenotypically NW history of recurrent miscarriage gonadal dysfunction xlinked disorders or congenital abnormalities andor developmental delay we investigated a patient with a de novo x translocation the sixyearold girl has been evaluated due to hyperactivity social interaction impairment stereotypic and repetitive use of language with echolalia failure to follow parentscaretakers orders inconsolable outbursts and persistent preoccupation with parts of objects the girl has normal cognitive function her measurements are within normal range and no other CA were found during physical neurological or dysmorphological examinations conventional cytogenetic analysis showed a de novo balanced translocation with the karyotype xtxpq replication banding showed a clear preference for inactivation of the normal x chromosome the translocation was confirmed by fish and spectral karyotyping sky although abnormal phenotypes associated with de novo balanced chromosomal rearrangements may be the result of disruption of a gene at one of the breakpoints submicroscopic deletion or duplication or a TPE x autosomal translocations are associated with additional unique risk AF including xlinked disorders functional autosomal monosomy or PET x chromosome disomy resulting from the complex xinactivation process | MEDAL |
early childhood caries affects nearly half the population of australian children aged years and has the potential to negatively impact their growth and OD to address this issue an early childhood oral health ecoh program facilitated by child and family health nurses cfhns commenced in in new south wales australia this T0 builds on the previous DUE of the program it aims to explore the perceptions of cfhns regarding the implementation of the ecoh program in south western sydney and the challenges and barriers related to its sustainability | MEDAL |
in the course of a research project aimed at the molecular characterization of balanced chromosome rearrangements associated with mental retardation mr several yacs spanning mrassociated chromosomal rearrangements in the qq region were identified to facilitate the search for relevant candidate genes we have analyzed a total of est clones from this region CS comparisons revealed that these clones represent up to distinct transcripts when no physical mapping data were available a minimal yac contig was screened for each unique transcript by the PCR reaction pcr or hybridization fiftyeight independent ests could be localized to yac clones between the markers ds and ds several ests are located on yac clones detecting chromosomal rearrangements in mr patients one est was mapped within the critical region for rieger syndrome type and three transcripts were identified in the region for the nocturnal enuresis type some ests showed homologies to known genes including the cadherinrelated tumor suppressor gene from drosophila the yeast MI control protein dis and the human alphamacroglobulin receptor associated protein | MEDAL |
to study the LT efficacy of tracheoesophageal te shunt phonation by the anastomosis of the membranous portion of the tracheal section with the anterior wall of esophagus T3 total laryngectomy | MEDAL |
we have written a program in basic language which stores recalls and manipulates a limited amount of clinical information that we use in teaching and clinical practice the program runs on an ibm personal computer with microsoft dos and basic an illustrative search routine uses simple data simulation of the results of argon laser trabeculoplasty therapy for openangle glaucoma | MEDAL |
given that there are few A-NK t nkt cells in the CL of nu/nu mice and in neonatally Tx mice it is still controversial whether all nkt cells existing in the CL are supplied by the thymus or if some such cells develop in the CL to determine whether or not nkt cells are consistently supplied from the thymus during AD life thymectomy was conducted in mice at the age of weeks interestingly the proportion and number of cd nkt cells increased or remained unchanged in the CL T3 adult thymectomy and this phenomenon continued for up to months T3 thymectomy the administration of alphagalactosylceramide induced severe cytopenia due to apoptosis of cd nkt cells in the CL on day but subsequent expansion of these nkt cells occurred in Tx mice similar to the case in NM however in thymectomized mice given lethal irradiation gy and subsequent bone marrow transfer the population of cd nkt cells no longer expanded in the CL although that of cd nkt cells did these results suggest that thymic cd nkt cells or their progenitors may migrate to the CL at a neonatal stage but are not supplied from the thymus in the AD stage under usual conditions cd nkt cells can be generated in the liver | MEDAL |
we studied the root CSD and the effects of leachates from the dominant shrub in rosemary scrub florida rosemary ceratiola ericoides on germination of seven subordinate rosemary scrub species for rosemary scrub specialists eryngium cuneifolium and hyeriences motion parallax the relative movement upon the observers retina of variously positioned objects in the scene this retinal movement of images provides a cue to the relative depth of objects in the environment however retinal motion alone cannot mathematically determine relative depth of the objects visual perception of depth from lateral observer translation uses both retinal image motion and eye movement in nawrot and stroyan vision res we showed mathematically that the ratio of the rate of retinal motion over the rate of smooth eye pursuit mathematically determines depth relative to the FP in CE vision we also reported on psychophysical experiments indicating that this ratio is the important quantity for perception here we analyze the motionpursuit cue for the more GA and more complicated case when objects are distributed across the horizontal viewing plane beyond central vision we show how the mathematical motionpursuit cue varies with different points across the plane and with time as an observer translates if the time varying retinal motion and smooth eye pursuit are the only signals used for this visual process it is important to know what is mathematically possible to derive about depth and structure our analysis shows that the motionpursuit ratio determines an excellent description of depth and structure in these broader stimulus conditions provides a detailed quantitative hypothesis of these visual processes for the perception of depth and structure from motion parallax and provides a computational foundation to analyze the dynamic geometry of future experiments | MEDAL |
intracellular ph mapping is of great importance as it plays a critical role in many cellular events also in tissue ph mapping can be an indicator for the ON of CA here we describe a biocompatible targeted ratiometric fluorescent ph sensing nanopebble photonic explorer for biomedical use with biologically localized embedding that is based on twophoton excitation twophoton excitation minimizes the photobleaching and cell autofluorescence drastically leading to an increase in the signaltonoise ratio pebble nanosensors provide a novel RPA for introducing membrane impermeant dyes like hpts into cells we use both nontargeted and f peptide targeted pebble nanosensors for intracellular ph measurement of l cells the intracellular measurements suggest that the nontargeted nanosensors are mostly trapped in endosomes whereas the f peptide targeting enables them to escapeavoid these acidic compartments combining the advantages of ph sensitive pebble NPs including their TPS targeting with the advantages of twophoton microscopy provides an attractive and promising prospect for noninvasive realtime monitoring of ph inside cancer cells and tissues | MEDAL |
obese men and women with the same BFM as well as obese women in another T0 were divided into CG with male or female type of body fat CSD but again with similar body fat mass the participants were examined with measurements of body composition including muscle fiber distribution as well as circulatory and metabolic variables before and T3 physical training under controlled conditions obese men had higher lean body mass blood pressure blood glucose and plasma insulin cpeptide cholesterol and triglyceride concentrations than age and body fatmatched obese women obese women with male type of AT CSD showed the same differences except cholesterol in comparisons with women with female type of adipose tissue distribution the women with male type obesity were also more insulin resistant in glucose clamp measurements and had male type of muscle fiber distribution PCS training in the group of obese men resulted in a decrease of body fat a further increase of lean body mass an increase of FT aerobic type muscle MF as well as lower plasma insulin cholesterol and triglyceride concentrations and lower blood pressure obese women with male type distribution of AT responded to PCS training essentially like men the insulin sensitivity was improved to the same level as in obese women with female type of adipose tissue CSD in contrast the latter women showed an increase of body fat and no metabolic improvements T3 training these results show that obese women with male type of body fat distribution also have male characteristics of MM morphology and function it is suggested that the obesity complications associated with this condition are improved by PCS training because of an adaptation to a NEB in combination with an improvement of insulin sensitivity of the MM in contrast the failure of obese women with female type of adipose tissue CSD to adapt to a negative EB during physical training is probably explaining their failure to decrease body fat and to improve metabolism during PCS training | MEDAL |
cardiac complications related to bone marrow grafting were investigated in a group of patients undergoing bone marrow transplantation autologous allogeneic in the transplant unit of hôpital saintantoine paris france between february and october the pregraft regimen was cyclophosphamide thioguanine cytosine arabinoside and ccnu tacc in cases cyclophosphamide cy associated with wholebody irradiation in cases and multiple chemotherapeutic agents in cases the study was retrospective in patients and prospective in the morbidity was and the mortality there were fatal cases of cardiomyopathies andor pericarditis nonfatal cases of HR failure nonfatal cases of pure pericarditis and arythmias including bradycardias diversely associated on a total of patients cyclophosphamide andor tacccyclophosphamide thioguanine CA and bcnu bact were the factors basically responsible for the cardiac toxicity the bestdefined entity was an acute fatal cardiomyopathy with associated pericarditis of which we report three additional cases the best predictors of cy toxicity were the daily weight a gain of more than kg for more than hours and the electrocardiogram a decrease of more than in the sum of the qrs complexes in the standard leads on the fourth day of chemotherapy routine echocardiography confirmed the high incidence of subclinical cardiac abnormalities and their reversibility it would seem that radiotherapy and anthracyclines play a AA role currently we consider that cardiac toxicity is one of the most important limiting AF for bone marrow transplantation we suggest therefore that the transplantation should be done as early as possible and preference should be given whenever possible to wholebody irradiation over highdose chemotherapy combinations such as tacc | MEDAL |
solidliquidvapor interfaces dominated by the threephase contact L1 usually performing as the AS center in reactions are important in biological and industrial processes in this contribution we provide direct threedimensional d exp evidence for the inside morphology of interfaces with either cassie or wenzel states at micron level using xray microcomputed tomography which allows us to accurately see inside the morphological structures and quantitatively visualize their internal d fine structures and phases in intact samples furthermore the indepth measurements revealed that the liquid randomly and partly located on the top of protrusions on the natural and artificial superhydrophobic surfaces in cassie regime resulting from thermodynamically optimal minimization of the surface SE these new findings are useful for the optimization of CP wetting theories and models which should promote the surface scientific and technological developments | MEDAL |
higher resting heart rate rhr is associated with increased risk of allcause and cardiovascular mortality with some reports showing the magnitude of association with allcause mortality being stronger than that with cardiovascular mortality this suggests that rhr association with mortality may not be limited to cardiovascular death we compared the association between rhr with cardiovascular and noncardiovascular mortality in participants mean age years women nonhispanic whites from the third national health and nutrition examination survey nhanesiii T3 excluding those on antiarrhythmic drugs or with missing data rhr data were obtained from standard lead electrocardiogram recorded on the nhanes participants during a PE NDI was used to identify the date and cause of death multivariable cox PH analysis was used to calculate the hazard ratios hrs and cis for cardiovascular mortality and noncardiovascular mortality separately associated with bpm increase in rhr during a median followup of years cardiovascular deaths and noncardiovascular deaths occurred in models adjusted for age gender race hypertension diabetes obesity dyslipidemia previous cardiovascular disease smoking CA chronic obstructive airway disease thyroid disease and serum creatinine higher rhr was associated with increased risk of both cardiovascular mortality and noncardiovascular mortality with a relatively similar magnitude of risk hr ci to and hr ci to respectively in conclusion higher rhr is associated with both cardiovascular mortality and noncardiovascular mortality suggesting that rhr is probably a marker of overall wellbeing rather than a marker of cardiovascular health | MEDAL |
cases of breast cancer t t treated by irradiation followed by radical mastectomy were subjected to histological revision in order to check the efficacy of radiotherapy in the local control of CA and to seek correlations between the histological findings and the clinical course of the disease the tumor disappeared completely only in of cases adiation were rendered incapable of suppressing the growth of grafted tumor cells sensitized with alloantibody the growth of sensitized tumor cells was suppressed when they were mixed with donor effector cells from mice syngeneic or allogeneic to the recipients and then were inoculated in irradiated recipients three donorhost combinations were used to study the suppression of the murine lymphoma ched indigenous to ch mice these were ch donor cells in ch recipients B6 donor cells in ch recipients or B6 donor cells in B6 recipients in all three combinations macrophages obtained from an inflammatory exudate exudate lymphocytes not bearing theta antigen and platelets were in descending order of effectiveness consistently active in restoring antibodymediated suppression of RT growth in irradiated hosts prior irradiation of the transferred lymphocytes somewhat diminished their effectiveness freezethawed or HK macrophages but not freezethawed platelets or lymphocytes were ERP in restoration IP blood MNC WBCs and splenic lymphoid cells were not AS in the recipients syngeneic to the donor cells but were acitve in recipients allogeneic to the donor cells polymorphonuclear leukocytes isolated from peripheral blood or an inflammatory exudate were not active intact thymic CF seems unimportant since antibodymediated suppression took place as effectively in thymectomized mice as in NCs | MEDAL |
the circadian clock gene period gryllus bimaculatus period gbper plays a core role in CR generation in adults of the cricket gryllus bimaculatus we examined the role of gbper in nymphal crickets that show a diurnal rhythm rather than the nocturnal rhythm of the adults as in the AD optic lobes gbper mrna levels in the head of the third instar nymphs showed daily cycling in L/D cycles with a peak at mid night and the rhythm persisted in constant darkness i.t. of gbper dsRNA dsrna into the abdomen of third instar nymphs knockeddown the mrna C2 to of that in control animals most gbper dsrna injected nymphs lost their circadian locomotor activity rhythm while those injected with dsred dsrna as a negative control clearly maintained the rhythm these results suggest that nymphs and adults share a common endogenous clock mechanism involving the clock gene gbper | MEDAL |
chitosan coated iron oxide nanoparticles were impregnated into polyacrylonitrile based hollow fiber membrane the molecular weight cut off was varied in the range of to kda with the concentration of nanoparticles incorporation of NPs improved the permeability mechanical property and hydrophilicity of the membrane the contact angle of the membrane decreased from ° to ° and the permeability increased by at wt nanoparticles concentration the antibacterial and antifouling property of the membrane were investigated with two biofilm causing gram positive and gram negative bacteria the damage of cell membrane was directly confirmed by PR of cellular constituent absorbing in nm the cellular deformation on the membrane surface was evident by direct microscopic observation in fesem this damage was likely caused by electrostatic interaction between nh | MEDAL |
dental treatment needs are commonly unmet among adolescents it is therefore important to clarify the determinants of poor utilization of dental services among adolescents | MEDAL |
viruslike particles were produced in insect cells infected with a recombinant baculovirus containing the CA gene of mx virus a mexican strain of human calicivirus these recombinant mx rmx particles were morphologically similar to recombinant norwalk virus rnv particles as observed under an EM and contained a single CA protein with a molecular weight of which was slightly smaller than that of rnv this protein was immunoprecipitated by sera from volunteers INF with the snow mountain agent but it reacted weakly with sera from volunteers infected with nv this protein did not react with hyperimmune antisera from animals immunized with rnv in the rnv antigen enzyme immunoassay eia seroresponses were detected from volunteers INF with snow mountain agent and hawaii agent when the rmx particles were used as antigen in an eia this eia also detected an immune response in the sera of child from whom the mx virus was isolated and a high prevalence of antibody to mx virus was found in the sera of a cohort of mexican children | MEDAL |
little information is available on proteolytic pathways responsible for muscle wasting in cancer cachexia experiments were carried out in young rats to demonstrate whether a small body weight RT may activate the lysosomal cadependent andor atpubiquitindependent proteolytic pathways in skeletal muscle five days T3 tumor implantation protein mass of extensor digitorum longus and tibialis anterior muscles close to a yoshida sarcoma was significantly reduced compared to the contralateral muscles according to in vitro measurements protein loss totally resulted from increased proteolysis and not from depressed protein synthesis inhibitors of lysosomal and cadependent PRs did not attenuate increased rates of proteolysis in the atrophying extensor digitorum longus accordingly cat b and bl MICs and mrna levels for cathepsin b were unchanged by contrast atp depletion almost totally suppressed the increased protein breakdown furthermore mrna levels for ubiquitin kda ubiquitin carrier protein e and the c or c proteasome subunits increased in the atrophying muscles similar adaptations occurred in the muscles from cachectic animals days after tumor implantation these data strongly suggest that the activation of the atpubiquitindependent proteolytic pathway is mainly responsible for muscle atrophy in yoshida sarcomabearing rats | MEDAL |
to estimate the number of patients with intractable respiratory diseases we conducted a twostage nationwide epidemiological survey in the first survey was performed at randomly sampled hospitals to identify the number of patients treated the second survey sought detailed clinicoepidemiological data on the patients reported in the first survey the response rates were for the first survey and for the second based on the survey findings we derived the following nationwide estimates patients confidence interval with chronic TE pulmonary hypertension with primary pulmonary hypertension with obesityassociated hypoventilation syndrome with primary alveolar hypoventilation syndrome with HX and with juvenile PE | MEDAL |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.