text
stringlengths 10
10.1k
| source
stringclasses 1
value |
|---|---|
to evaluate the behavior of exercise parameters in patients with different angiographically defined degrees of revascularization serial exercise tests were analyzed in patients to years after coronary i.a. bypass grafting cabg all patients had undergone postoperative angiography to months after cabg to determine the degree of revascularization achieved revascularization was complete in patients all significantly stenosed arteries had patent grafts sufficient in patients at least the dominant artery supplying the LV had a patent graft and incomplete in patients the dominant i.a. supplying the left ventricle had a closed graft twenty patients had all grafts occluded ET anginafree ET angina threshold maximal DP prevalence of greater than or equal to mv exerciseinduced st segment depression and the prevalence of the combination of st segment depression plus angina pectoris were determined in serial exercise tests average of postoperative exercise tests per patient for a mean follow up of years patients with complete sufficient and incomplete revascularization showed improvement of all exercise parameters for and year T3 cabg respectively patients with all grafts occluded had improvement of only some exercise parameters five years T3 cabg ET was improved by w p less than and w p less than in patients with CR and sufficient revascularization respectively and not improved in patients with incomplete revascularization or with all grafts occluded the angiographically determined completeness of revascularization correlates with the extent and the duration of improvement of exercise parameters after cabg | MEDAL |
the hydroxylation of debrisoquine was investigated in spraguedawley sd and darkagouti da rats female and male rats were phenotyped invivo with DBQ six times during their growth the ratios debrisoquinehydroxydebrisoquine of the female da rats increased until the th week and then decreased but the values of the metabolic ratios never exceeded female da rats cannot be considered as genetically deficient for hydroxylation of debrisoquine in regard to the metabolic ratio but the percentage of DBQ excretion is up to ten fold higher than that in the other strains therefore sd and da rat livers were perfused for h when the clearance of debrisoquine was significantly lower in the female da group than in the other CG hydroxydebrisoquine in the perfusate increased with time but the amount after min was fold lower in the female da rat group than in the female sd rat group the results of the male da group fell between this study confirms that female da rats present a lower DBQ hydroxylating capacity than other rats but shows that urinary metabolic ratio is not sufficient to assess the deficiency of DBQ hydroxylation | MEDAL |
avoidance of manipulation of diseased ascending aorta has been shown to be associated with a reduced risk of postoperative stroke T3 offpump coronary artery bypass surgery opcab the use of the heartstring device guidant indianapolis usa to accomplish a PT aortic anastomosis without aortic clamping has been suggested in such patients | MEDAL |
deep vein thrombophlebitis dvt and septic pulmonary emboli pe are rare in children the association of dvt and acute disseminated staphylococcal disease dsd during childhood has not been previously reported we report children who developed a triad of dvt septic pe and acute osteomyelitis with staphylococcus aureus cultured from blood and bone one child succumbed while survived following prolonged morbid hospitalizations the rapid clinical deterioration observed in these patients might be caused by the aggressiveness of staphylococcal infection combined with an ongoing showering of septic emboli from the ileofemoral dvt we suggest that INF dvt with septic pe had a pivotal role in the OD of dsd in these children the presence of this triad should prompt aggressive treatment with the AGA antibiotics AC surgical drainage and AV when indicated | MEDAL |
a neonate with oral lesions of pemphigus vulgaris is described the diagnosis was confirmed by cytological examination of lesions positive intercellular igg IF of the acantholytic cells and presence of pemphigus antibodies in his SS at the time of delivery the childs mother had active pemphigus vulgaris and it is suggested that this was a case of passively transferred disease | MEDAL |
polyapositive mrna extracted from tonsillar mononuclear cells stimulated with phytohemagglutininm and otetradecanoyl phorbol acetate was successfully translated into biologically AS interleukin il in xenopus laevis oocytes and secreted into the incubation medium in control experiments the extract of oocytes injected with either polyanegative rna or buffer did not show any il activity by SU density gradient centrifugation analysis il mrna was found as a single peak corresponding to a sedimentation coefficient of s | MEDAL |
movement of the mechanically ventilated patient may be for a routine procedure or medical emergency the risks of transport seem manageable but the SM of a respiratoryrelated catastrophe still gives many practitioners pause the riskbenefit ratio of transport must be assessed before movement during transport of the ventilated patients should we always use a transport ventilator what is the risk of using manual ventilation how are peep and fio altered is there an impact on the ability to trigger during manual ventilation is HV and hypoventilation a common problem does hyperventilation or hypoventilation result in complications are portable ventilators worth the cost what about the function of portable ventilators can these devices faithfully reproduce icu ventilator CF the following pro and con discussion will attempt to address many of these issues by reviewing the current evidence on transport ventilation | MEDAL |
longitudinal growth determined by roentgen stereophotogrammetry was registered in three patients with physial injuries in distal femur and in two patients with physial injuries in proximal tibia during months the injuries in distal femur were classified as type i type i kii and type iv and in PT tibia as type i kii and type iv in the different cases according to salter and harris markers of Ta balls were implanted into the metaphysis and bony epiphysis of distal femur and PT tibia permitting regular determination of longitudinal growth significant growth disturbances was registered in four patients the salterharris classification was difficult to use to predict growth disturbance T3 physial injuries around the knee the roentgen stereophotogrammetric method was found useful to determine normal growth rate and T3 physial injuries to reveal growth disturbance leading to complete or partial growth arrest resulting in leg length discrepancy or angular deformity this method facilitates preoperative planning if surgery is needed | MEDAL |
blind people are known to have superior perceptual abilities in their remaining senses several studies suggest that these enhancements are dependent on the specific experience of blind individuals who use those remaining senses more than sighted subjects in L1 with this view sighted subjects when TR are able to significantly progress in relatively simple tactile tasks however the case of complex tactile tasks is less obvious as some studies suggest that visual deprivation itself could confer large advantages in learning them it remains unclear to what extent those complex skills such as braille reading can be learnt by sighted subjects here we enrolled twentynine sighted adults mostly braille teachers and educators in a month braille reading course at the beginning of the course all subjects were naive in tactile braille reading after the course almost all were able to read whole braille words at a mean speed of wordsperminute subjects with low tactile acuity did not differ significantly in braille reading speed from the rest of the group indicating that low tactile acuity is not a limiting factor for learning braille at least at this early stage of learning our study shows that most sighted adults can learn wholeword braille reading given the RA method and a considerable amount of motivation the adult sensorimotor system can thus adapt to some level to very complex tactile tasks without visual deprivation the pace of learning in our group was comparable to congenitally and early blind children learning braille in primary school which suggests that the blinds mastery of complex tactile tasks can to a C1 extent be explained by experiencedependent mechanisms | MEDAL |
the proton permeation process of the stator complex motab in the flagellar motor of escherichia coli was investigated the atomic MM structure of the transmembrane part of motab was constructed based on the previously published disulfide crosslinking and tryptophan scanning mutations the dynamic permeation of hydroniumsodium ions and water molecule through the channel formed in motab was observed using a SMD simulation during the simulation leu of motb acts as the gate for hydronium ion permeation which induced the formation of water wire that may mediate the proton transfer to asp on motb free energy profiles for permeation were calculated by umbrella sampling the free energy barrier for ho permeation was consistent with the proton transfer rate deduced from the flagellar rotational speed and number of protons per rotation which suggests that the gating is the ratelimiting step structure and dynamics of the motab with nonprotonated and protonated asp valmet and valleu mutants in motb were investigated using molecular dynamics simulation a narrowing of the channel was observed in the mutants which is consistent with the sizedependent ion selectivity in motab with the nonprotonated asp the a segment in mota maintained a kink whereas the protonation induced a straighter shape assuming that the cytoplasmic domain not included in the atomic model moves as a rigid body the protonationdeprotonation of asp is inferred to induce a ratchet motion of the cytoplasmic domain which may be correlated to the motion of the flagellar rotor | MEDAL |
wild boar sus scrofa populations are increasing in the iberian peninsula and population management must include disease management and control in this T0 the epidemiology of selected pathogens ADV adv porcine reproductive and respiratory syndrome virus prrsv porcine influenza virus porcine circovirus porcine parvovirus erysipelotrix rhusiopathiae leptospira pomona chlamydiachlamydiaceae sp salmonella sp and mycobacterium bovis in the wild boar population in sierra nevada national park snnp an open unfenced area is reported taking into account wild boar population abundance R2 in space and time in an open unfenced environment a total of wild boar were sampled in hunting events randomly carried out for sampling in seven hunting seasons october to february from to except prevalence was overall lower than those previously reported for fenced wild boar populations in spain but all the pathogens analyzed except prrsv were considered endemic in the snnp adv e rhusiopathiae and total pathogen prevalence were positively correlated to wild boar density prevalence in the positive Az was significantly higher in females for adv e rhusiopathiae l pomona chlamydiachlamydiaceae sp and salmonella sp and in males for m bovis this longitudinal T0 provides the first data on the health status of the relatively unmanaged and low density wild boar population of snnp it is concluded that nonintensively managed wild boar populations are able to maintain the circulation of several pathogens even in low prevalences and in open unfenced areas with natural density variation both in time and space | MEDAL |
chinese hamster v cells were treated with high cytotoxic or low noncytotoxic concentrations of the highly carcinogenic and mutagenic rssrdihydroxy epoxytetrahydrobenzocphenanthrene bcphde fjordregion diol epoxide or its biologically less AS srrs enantiomer bcphde the benzylic hydroxyl group and the epoxide oxygen are trans in both enantiomers independent azaguanineresistant clones were isolated the coding region of the hypoxanthine guanine phosphoribosyltransferase gene was amplified by reverse transcriptionpcr and sequenced for bcphde mutation frequencies were or fold above BG for the low microm cell survival or high microm cell survival doses respectively for the high dose group of base substitutions occurred at gc base pairs and at at base pairs for the lowdose group of base substitutions were at gc base pairs and were at at base pairs for the less AS bcphde mutation frequencies were or fold above background for the low microm cell survival or high microm cell survival doses respectively in contrast to the results with the bcphde both the high and the lowdose CG for bcphde gave a distribution of base substitution at gc versus at base pairs our data indicate that a transversions were the predominant base substitutions observed for both the and enantiomers of bcphde b bcphde showed high selectivity for causing at ta transversions whereas considerably less selectivity was observed for bcphde c bcphde had a different hot spot profile for base substitutions than did bcphde but some common hot spots were observed for both compounds and d decreasing the dose of bcphde increased the proportion of mutations at at base pairs and decreased those at gc base pairs but this was not observed for bcphde | MEDAL |
analytical and computational models of the IVD ivd are commonly employed to enhance understanding of the biomechanics of the human spine and spinal motion segments the accuracy of these models in predicting physiological behaviour of the spine is intrinsically reliant on the accuracy of the material constitutive representations employed to represent the spinal tissues there is a paucity of detailed mechanical data describing the material response of the reinforcedground matrix in the AF of the ivd in the present T0 the reinforcedground matrix was defined as the matrix with the collagen fibres embedded but not actively bearing axial load thus incorporating the contribution of the fibrefibre and fibrematrix interactions to determine mechanical parameters for the anulus ground matrix mechanical tests were carried out on specimens of ovine anulus under unconfined uniaxial compression simple shear and biaxial compression test specimens of ovine anulus fibrosus were obtained with an adjacent layer of vertebral bonecartilage on the superior and inferior specimen surface specimen geometry was such that there were no continuous collagen fibres coupling the two endplates samples were subdivided according to disc region anterior lateral and posterior to determine the regional inhomogeneity in the anulus mechanical response specimens were loaded at a SR sufficient to avoid fluid outflow from the tissue and typical stressstrain responses under the initial load application and under repeated loading were determined for each of the three loading types the response of the anulus tissue to the initial and repeated load cycles was significantly different for all load types except biaxial compression in the anterior anulus since the maximum applied strain exceeded the damage strain for the tissue exp results for repeated loading reflected the mechanical ability of the tissue to carry load subsequent to the initiation of damage to our knowledge this is the first study to provide exp data describing the response of the reinforcedground matrix to biaxial compression additionally it is novel in defining a study objective to determine the regionally inhomogeneous response of the reinforcedground matrix under an extensive range of loading conditions suitable for mechanical characterisation of the tissue the results presented facilitate the OD of more detailed and comprehensive constitutive descriptions for the large CS nonlinear elastic or hyperelastic response of the anulus ground matrix | MEDAL |
AD has potentially lifethreatening consequences in quadriplegics and high paraplegics seizures subarachnoid hemorrhage and fatal stroke may result this article explains the pathophysiology of autonomic dysreflexia AGA nursing interventions to prevent serious complications are described | MEDAL |
the soil removal SMB from polyethylene terephthalate pet films was investigated using a microscopic image analysis system carbon black or stearic acid as a model soil was deposited onto a pet film the pet film was cleaned in various AQ and nonaqueous solutions by applying stirring or frequencymodulated ultrasound as a mechanical action of soil removal the amounts of soil deposited on the pet film before and T3 cleaning were obtained via binary processing of microscopic images from which the RE was calculated most of the carbon black was deposited on the pet film as submicron aggregates and ultrasound removed them efficiently in a short time even for relatively smaller aggregates the removal efficiencies with stirring were less than ca in all solutions whereas the removal using ultrasound had high efficiencies that exceeded in the surfactantfree systems in the case of stearic acid the removal efficiency with stirring was below in the aqueous solutions although stearic acid was removed completely in ethanol and ndecane for US cleaning the removal efficiencies of stearic acid in aqueous solutions became times as large as those with the stirring action to improve soil release in aqueous solutions the pet film was treated by the dry processing using an atmospheric pressure plasma jet appj equipment the wettability and the SFE of the pet film were found to increase due to surface oxidation via the appj treatment which resulted in enhanced removal of carbon black and stearic acid in any AQ solutions | MEDAL |
a purified papaya laccase was immobilized in chitosan beads using entrapment approach and its physicochemical properties were investigated and compared with that of free enzyme increase in properties of the laccase such as optimum temperature by °c thermostability by folds and optimum ph from to was observed T3 immobilization immobilization led to increased tolerance of enzyme to a number of metal ions including heavy metals and organic solvents namely ethanol isopropanol methanol benzene and dmf the catalytic efficiency kcatkm of the immobilized enzyme was found to increase more than ten folds in comparison to that of the free enzyme with hydroquinone as ATP immobilization of laccase also led to improvement in dye decolorization such that the synthetic dye indigo carmine μgml was completely decolorized within h of incubation as compared to that of the free laccase which decolorized the same dye to only under similar conditions thus immobilization of laccase into chitosan beads led to tremendous improvement in various useful attributes of this enzyme thereby making it more versatile for its industrial exploitation | MEDAL |
usher syndrome is a heterogeneous group of autosomal recessive disorders that combines variably severe congenital neurosensory hearing impairment with progressive nightblindness and visual loss similar to that in retinitis pigmentosa usher syndrome type i is distinguished by profound congenital preverbal deafness and retinal disease with ON in the first decade of life usher syndrome type ii is characterized by partial hearing impairment and retinal dystrophy that occurs in late adolescence or early adulthood the chromosomal assignment and the regional localization of the genetic mutations causing the usher syndromes are unknown we analyzed a panel of polymorphic genomic markers for linkage to the disease gene among six families with USH1 and families with usher syndrome type ii significant linkage was established between usher syndrome type ii and the dna marker locus thh ds which maps to chromosome q the most likely location of the disease gene is at a map distance of cm from thh lod score the same marker failed to show linkage in families segregating an S2 for usher syndrome type i these data confirm the provisional assignment of the locus for usher syndrome type ii to the distal end of chromosome q and demonstrate that the clinical heterogeneity between usher types i and ii is caused by mutational events at different genetic loci regional localization has the potential to improve carrier detection and to provide antenatal diagnosis in families at risk for the disease | MEDAL |
the toxic a chain of abrin was isolated by AC and was demonstrated to be a potent inhibitor of protein synthesis in a cellfree rb reticulocyte system with a complete inhibitory dose at x m this a chain was coupled by a disulfide linkage to a purified monoclonal antibody directed against a tumorassociated antigen found on the line HCC RT in CS two guinea pigs the immunoconjugate retained the functions of the individual components ie antigen IB to the intact cell in vitro and inhibition of its protein synthesis this conjugate was a selective antineoplastic agent with a cytocidal dose at x m toward antigenbearing cells in vitro several antigennegative cells were much less susceptible to its cytotoxic effect the cytotoxicity of the conjugate appeared to be by antibodymediated delivery of toxic a chain into the target cell when cells were pretreated with excess free antibody followed by a brief exposure to conjugate there was a reversal of the cytotoxicity to antigenpositive cells but not to the antigennegative cells the therapeutic efficacy of the conjugate was assayed by injecting a single dose sc or iv into syngeneic guinea pigs bearing established line tumors these in vivo studies showed that a the conjugate was not toxic at a dosage of to microgramsguinea pig b the conjugate decreased or abolished the growth of established ST c the conjugate delayed or inhibited tumor metastases to lymph nodes and d to of the animals in selective groups had a longterm complete regression | MEDAL |
fluorescence correlation spectroscopy fcs is a very CS technique that can be used eg for the measurement of low concentrations and for the investigation of transport of fluorescent molecules fluorescence lifetime imaging flim provides spatially resolved information about molecular fluorescence lifetimes reflecting the interactions of the molecules with their environment we have applied simultaneous twophoton fcs and flim to probe the behavior of FL molecules diffusing in submicrometer Si oxide channels our measurements reveal differences in fluorescence lifetimes compared to bulk solution that result from the effects of confinement and the presence of interfaces confinement also affects diffusional characteristics of fluorophores as reflected in fluorescence autocorrelation functions these possible consequences of both spatial confinement and the presence of interfaces between media with different refractive indices on the DWI and fluorescence lifetime of molecules in nanostructures are discussed in general | MEDAL |
a total of neurons were antidromically driven in quasicortical regions ie anterior olfactory nucleus basolateral amygdala main olfactory bulb prefrontal cortex and in the HPC formation following macro and microstimulation of the rats ventrostriopallidal region vspr in addition a substantial number of units n were also transynaptically affected in all these structures by shocks delivered to theas assayed in skinned RAS preloaded for minutes with ca in the absence of k Ox and desaturated with washing solutions containing nm free ca mm of caffeine microm of norepinephrine or microm of ip resulted in greater increases in the rates of ca efflux in wky than in shr aortic strips net effluxes of ca upon stimulation with all these drugs were statistically significant only in the hypertensive group due to its slightly but consistently higher ca content changes in both rate of efflux and net efflux induced by mm of caffeine could be blocked by mm of ryanodine the sarcoplasmic reticulum is characterized in the genetically hypertensive rats by a low transport activity of its caatpase a high ca content and a ca release mechanism with low responsiveness to stimulation by caffeine norepinephrine and ip | MEDAL |
improving the frequency precision by synchronizing a lattice of n oscillators with disparate frequencies is studied in the phase reduction limit in the GA case where the coupling is not purely dissipative the synchronized state consists of targetlike waves radiating from a local source which is a region of higherfrequency oscillators in this state the improvement of the frequency precision is shown to be independent of n for C1 n but instead depends on the disorder and reflects the dependence of the frequency of the synchronized state on just those oscillators in the source region of the waves these results are obtained by a mapping of the nonlinear phase dynamics onto the linear anderson problem of the quantum mechanics of electrons on a random lattice in the tightbinding approximation | MEDAL |
a multimedia transport MM was used to evaluate the environmental partitioning of benzoapyrene bap measured and predicted environmental concentrations were used to estimate the accumulation of bap in the food chain and the subsequent extent of human exposure from inhalation and ingestion results show that bap partitions mainly into soil and sediment and that the food chain is the dominant pathway of human SE accounting for about of the total daily NI of bap inhalation and consumption of contaminated water are only minor pathways of human SE the longterm average daily intake of bap by the GA population of the us is estimated to be micrograms micrograms per day CS and indoor activities do not substantially increase human exposure to bap relative to exposures to BG levels of bap present in the environment since the increased lifetime risk associated with human exposure to background levels of bap is x we conclude that ingestion of food items contaminated with bap may pose a serious health threat to the us population | MEDAL |
we examine two freeenergybased methods for studying the wetting properties of a fluid in contact with a solid substrate application of the first approach involves examination of the adsorption SMB of a fluid at a single substrate while the second technique requires investigation of the properties of a system confined between two parallel substrates both of the techniques rely upon computation and analysis of the density dependence of a systems SFE and provide the CA and solidvapor and solidliquid interfacial tensions for substratefluid combinations within the partial wetting regime grand canonical transition matrix MC simulation is used to obtain the required freeenergy curves the methods examined within this work are general and are applicable to a wide range of molecular systems we probe the performance of the methods by computing the interfacial properties for two systems in which an atomistic fluid interacts with a fcc crystal for both of the systems studied we find good PA between our results and those obtained via the mechanical definition of the IFT | MEDAL |
ten yearling whitetailed deer odocoileus virginianus were inoculated with bluetongue virus serotype two yearling whitetailed deer were inoculated with sonicated heparinized noninfected blood and served as controls clinical signs of bluetongue virus infection included increased rectal temperature erythema facial edema coronitis and stomatitis by postinoculation day pid excessive one and hematoma formation at venipuncture CS dehydration and diarrhea developed at necropsy the most consistent findings were oral lesions and widespread hemorrhage which ranged from petechia to massive hematoma formation bluetongue virus caused progressive prolongation of APTT time and prothrombin time and progressive reduction of factors viii and xii plasma MICs beginning on pid a progressive decrease in PLT numbers also developed on pid changes in PLT size were not detected mean thrombin time was shortened but prolongation developed in deer mean fibrinogen concentration and factor v plasma activity initially increased and then decreased but remained above preinoculation values FV activity was low in a few deer results of screening tests for inhibitors of the intrinsic coagulation system were positive in deer high concentrations of fibrinogen Kd products were first detected between pid and hematologic changes included leukopenia lymphopenia neutrophilia and low total plasma protein concentration differences in pcv hemoglobin concentration or rbc counts were ND between infected and control deer SS total bilirubin concentration increased by pid primarily because of increased free bilirubin concentration mild to severe increases in serum aspartate transaminase activity were accompanied by more marked increases in CK indirect coombs test results were negative in all deerabstract truncated at words | MEDAL |
the steroid hormone betaestradiol dramatically induces uterine nlinked glycoprotein assembly dutt a tang jp welply j k carson d d endocrinology baltimore to determine the role that dolichyl phosphate availability plays in this induction we studied the effects of estrogen priming on the content of dolichyl phosphate and the distribution of dolichyl phosphate among various glycolipids in uteri dolichollinked saccharides were metabolically labeled to equilibrium with either hglucosamine or hmannose and extracted from primary explants of uterine tissue the amount of dolichollinked saccharide was calculated from the specific radioactivity determined for the corresponding sugar nucleotides extracted from the tissues the L1 dolichollinked saccharides identified were mannosylphosphoryldolichol mpd oligosaccharylpyrophosphoryldolichol osl and nndiacetylchitobiosylpyrophosphoryldolichol cbl estrogen increased the levels of mpd and osl fold however B6 C2 did not NC after days of treatment the levels of these glycolipids were very similar to those in uteri from pregnant mice remarkably mpd constituted of dolichollinked saccharides detected under all conditions the tissue contents of total Dol-P and alkalilabile Dol-P presumably mpd were estimated by liquid chromatography the levels of alkalilabile Dol-P determined in this way were in good agreement with the values estimated for mpd by metabolic labeling moreover alkalilabile dolichyl phosphate constituted of the total Dol-P pool the variations in mpd content depended upon the steroid hormone influence most notably that of estrogenabstract truncated at words | MEDAL |
we performed demographic analyses on cassins auklet ptychoramphus aleuticus a zooplanktivorous seabird inhabiting the VL california current system to understand how temporal environmental variability influences population dynamics we used CR data from to to rank models of interannual variation in survival breeding propensity breeding success and recruitment all demographic parameters exhibited temporal R2 interannual variation in survival was best modelled as a nonlinear function of the winter southern oscillation index soi breeding propensity was best modelled as a threshold CF of local sea surface temperature breeding success and recruitment were best modelled with yeardependent annual R2 changes in the soi force el niñola niña events which in turn alter prey availability to seabirds in this system demographic responses varied during el niñosla niñas survival diminished substantially during the el niño event while breeding propensity was affected during both the and el niños breeding success was reduced during the and el niños but was unusually high in recruitment was higher at the beginning and end of this timeseries while demographic responses varied interannually parameter values covaried in a positive fashion a situation conducive to rapid population NC during the years study period the farallon auklet breeding population declined at se per year a cumulative decline of this study demonstrates how climate variability has influenced key demographic processes for this diminished marine bird population | MEDAL |
the aim was to use a computer model to estimate the costeffectiveness of slice multidetector computed tomography mdct of the CAs in the emergency department ed compared to an observation unit ou stay plus AS electrocardiogram ecg or stress echocardiography for the DUE of lowrisk chest pain patients presenting to the ed | MEDAL |
ige antibodies directed against strongyloides stercoralis larval antigens were measured by a newly developed radioallergosorbant test rast one hundred and fiftytwo samples of sera from patients with parasitologically proven s stercoralis infection were tested one hundred and thirtysix of these were positive for parasitespecific ige of presumably noninfected north american adult control sera were negative all sera from patients with other parasites were negative except for two sera from subjects with ascaris lumbricoides who exhibited low positivity of eight sera from noninfected patients with allergies and high ige C2 one was weakly positive and the other seven were negative considerable individual R2 was present in the C2 of TPS ige as measured by the rast in the infected patients significant differences were also found among the three L1 demographic groups which composed our study population with asians having higher values than latin americans and the latter having higher values than north american patients we conclude that the majority of patients with strongyloidiasis develop RAST directed against antigens from filariform larvae the invasive form of the parasite while the PET significance of this response remains to be defined the rast for ige may be a useful adjunct in the immunological DUE of these patients | MEDAL |
the typical calpain proteases are a subset of a wider superfamily and regulate a broad spectrum of physiological processes here we characterised atlantic halibut completecoding orthologues of calpain calpainlike musclespecific calpain plus calpain a recently recognised vertebratewide family member phylogenetic analysis established the relationship of each sequence within a comprehensive FR of vertebrate calpains including teleost paralogues this approach provided significant insight into the evolution of teleost calpains for example teleost sequences considered calpain orthologues formed a monophyletic clade external to sister clades for tetrapod calpain and vertebrate calpain thus teleost calpain is likely not directly orthologous to tetrapod calpain and represents a calpainlike protein the characteristic domain structure of typical calpains was observed in each halibut sequence although calpain as for other teleosts retained only one is of three further domains found in human calpain ns is and is transcripts for capn capnlike and capn were widely detected across eleven halibut tissues whereas capn was detected in striated muscles SP and ovary but absent or relatively less abundant in other tissues we assessed the transcript expression of each calpain gene in fasttwitch skeletal muscle where nutritional state was altered with days feed restriction followed by days satiation refeeding measured by quantitative RT pcr capn transcript C2 were highest during maximal fasting and then steadily decreased with refeeding where muscle was in net positive protein balance conversely capnlike showed little response whereas capn and capn transcript levels were lowest at maximal fasting before being strongly constitutively upregulated with subsequent refeeding halibut capn transcript abundance was on average and fold greater than capn capnlike and capn respectively in skeletal muscle across nutritional states in turn transcript levels of capn and capn were invariably higher than capnlike but were dependent on nutritional state compared to each other the differential regulation of these genes in response to NS suggests distinct roles for typical calpain family members in regulating the balance between catabolism and growth in teleost skeletal muscle | MEDAL |
to explore the clinical effects of anterior decompression and F0 with a nanohydroxyapatite polyamide nhapa cage in treating lower cervical fracture and dislocation | MEDAL |
there has been a recent surge in the use of electroencephalography eeg as a tool for mobile BB imaging due to its portability and fine time resolution when eeg is combined with independent component analysis ica and source localization techniques it can MM electrocortical activity as arising from temporally independent signals located in spatially distinct cortical areas however for mobile tasks it is not clear how movement artifacts influence ica and source localization we devised a novel method to collect pure movement artifact data devoid of any electrophysiological signals with a channel eeg system we first blocked true electrocortical activity using a silicone swim cap over the silicone SL we placed a simulated scalp with electrical properties similar to real human scalp we collected eeg movement artifact signals from ten healthy young subjects wearing this setup as they walked on a TM at speeds from ms we performed ica and dipole fitting on the eeg movement artifact data to quantify how accurately these methods would identify the artifact signals as nonneural ica and dipole fitting accurately localized of the independent components in nonneural locations or lacked dipolar characteristics the remaining of sources had locations within the brain volume and low residual variances but had topographical maps SP spectra time courses and event related spectral perturbations typical of nonneural sources caution should be exercised when interpreting ica for data that includes semiperiodic artifacts including artifact arising from human walking alternative methods are needed for the identification and separation of movement artifact in mobile eeg signals especially methods that can be performed in real time separating true brain signals from motion artifact could clear the way for eeg BB computer interfaces for assistance during mobile activities such as walking | MEDAL |
chronic kidney disease ckd is a L1 and serious risk factor for cardiovascular disease cvd continuous hypoxia due to hypoperfusion in peritubular capillaries is one of the factors aggravating ckd but DUE of perfusion in this region is difficult using clinically available imaging methods since the secondgeneration ultrasound UCA sonazoid has a stable shell it enables visualization of the renal vasculature for a long period of time we therefore evaluated changes in contrastenhanced ultrasound ceus imaging with sonazoid in ckd patientssonazoid was used in ckd patients and control subjects and images were recorded for T2 timeintensity curves were generated from the images of time points in both cortex and medullain control samples CE spread from the hilar portion to the periphery along the direction of arterial flow and renal SC and medulla were then enhanced in CS enhancement was maximal soon after then gradually decreased but was still visible at seconds in ckd patients renal contrast enhancement was attenuated in both cortex and medulla on timeintensity curves the attenuation of enhancement was composed of delayed rising reduction of peak and acceleration of decay in both SC and medulla with progression of renal dysfunction no side effects of the UCA were observed in any subjectsthe attenuation of renal contrast enhancement observed in ckd patients appears to reflect disturbance of perfusion in peritubular capillaries ceus with sonazoid is a useful and safe means of visualizing the renal microvasculature | MEDAL |
in the present T0 to clarify the role of protein kinase c pkc in the regulation of monocarboxylate transporter mct expression we examined the regulation mechanism of mct expression in human rhabdomyosarcoma rd cells an in vitro skeletal muscle model exposure of rd cells to pma a pkc activator for h resulted in a twofold increase in the amount of LA in the growth medium in parallel to an increase in LA release from rd cells the level of mct mrna and protein were also significantly increased in rd cells a pkc GABA study indicated that pmainduced stimulation of mct expression can be mediated through a novel pkc isoform especially pkcδ moreover rottlerin a selective pkcδ inhibitor decreased pmainduced mct promoter activity deletion and mutational analysis suggested that the potential hypoxiaresponse elements hres played a major role in the observed modulation of mct expression by pma furthermore we found that small interfering rna sirnamediated knockdown of hypoxiainducible factor α hifα significantly inhibited pmainduced mct promoter activity our results show that the effects of pma on mct expression are mediated through an indirect pathway partially involving pkcδ and hifα transcription factor | MEDAL |
one hundred and three primigravidae were studied to establish the correlation between physical fitness and HV twentythree of the mothers were allocated at random to the exercise group and to control group between the th and th weeks of pregnancy in addition mothers were allocated to control group which was formed two weeks before term the exercise group underwent a rather strenuous training programme during pregnancy PCS fitness was measured by work tests on a bicycle ergometer two weeks before term the HV was determined radiologically on the th day post partum therestionable in the present study bicompartmental analysis performed by a leastsquare computerized iterative RPA was used in the calculation of the flow and weight of the tissue of the brain of patients with severe head injuries the analysis was found to give important information of the nature and course of the brain lesions even if the clearance curves did not have the normal biexponential shape provided the results obtained were properly interpreted in such cases the values of the flow and RW could not be taken as flow and weight values of gray and VWM but rather as indices of fast and slower flow components the interpretation of the results was based on the identification of three types of minute clearance curves each being characteristic of a type of BB lesion the clearance curves from fairly normal brain tissue appeared to be biexponential curves from Az of severe cortical contusion had in addition an initial and rapid third component a tissue peak whereas curves from severely edematous brain tissue approached the monoexponential shape | MEDAL |
information that would allow the identification of women who were Pr at the time of death or within the year preceding death has historically been underreported on death certificates as a result the magnitude of the problem of pregnancyassociated mortality is underestimated to improve the ID of these deaths check boxes for reporting pregnancy status have been added to death certificates in a number of states we used multiple external data sources to determine whether check boxes have been ERP in identifying pregnancyassociated deaths | MEDAL |
thymol is a phytochemical component present in many plants used as food additive in order to promote animal growth due to its several biological properties however possible side effects of thymol remain poorly known limited to few reports in this sense we evaluated the enzymes of the purinergic signaling such as ectonucleoside triphosphate diphosphohydrolase ntpdase nucleotidase and adenosine deaminase ada that play an important role on toxicity induced by excessive adenosine triphosphate atp content in the extracellular environment thus the aim of this study was to evaluate whether purinergic signaling could be considered a potential target of thymolinduced inflammation and the toxicity in tissues and immune cells of mice after thymol administration ntpdase activity atp as ATP in SS SP and splenic lymphocytes was lower after days of oral treatment at doses of and mgkg of thymol while ada activity was stimulated at and mgkg no differences were observed between groups regarding ntpdase adp as ATP and nucleotidase MICs in all evaluated tissues based on these evidences adenine nucleotide hydrolysis is modified in SS spleen and splenic lymphocytes of mice treated with thymol contributing to inflammation and toxicity by a reduction on atp hydrolyses and its possible accumulation in the extracellular medium and increased ado desamination and its possible reduction in the extracellular environment leading to a selfsustained Th1 recisely controlled brush stroking speed and force on the skin a usability study of monthold infants was conducted to investigate the tolerability and feasibility of the system results have shown that the system is well tolerated by infants and all the data were collected robustly this paper paves the way for future studies charting the sensory response trajectories in infancy | MEDAL |
abberant activation of the process of epithelialmesenchymal transition in cancer cells is a late event in tumor progression a key inducer of this transition is the transcription factor snail which represses ecadherin we report that conditional expression of the human transcriptional repressor snail in CC cells induces an epithelial dedifferentiation program that coincides with a drastic change in cell morphology snail target genes control the establishment of several junctional complexes intermediate filament networks and the actin cytoskeleton modulation of the expression of these genes is associated with loss of cell aggregation and induction of invasion chromatin immunoprecipitation experiments showed that repression of selected target genes is associated with increased binding of snail to their promoters which contain consensus snailbinding sites thus snail constitutes a master switch that directly represses the epithelial phenotype resulting in malignant carcinoma cells | MEDAL |
vascular leakage is a lifethreatening complication of dengue virus denv infection previously association between paracellular endothelial hyperpermeability and plasma leakage had been extensively investigated however whether transcellular EC leakage is involved in DHF dhf and dengue shock syndrome dss remained unknown we thus investigated effects of denv serotype infection on transcellular transport of albumin the main oncotic plasma protein through human EC cell monolayer by WB immunofluorescence staining fluorescence imaging and fluorometry the data showed that alexaconjugated bovine serum albumin alexabsa was detectable inside denvinfected cells and its level was progressively increased during h postinfection while paracellular transport could be excluded using fitcconjugated dextran alexabsa was progressively increased and decreased in lower and upper chambers of transwell respectively pretreatment with nystatin an inhibitor of caveolaedependent endocytic pathway significantly decreased albumin internalization into the denvinfected cells whereas inhibitors of other endocytic pathways showed no significant effects colocalization of the internalized alexabsa and caveolin was also observed our findings indicate that denv infection enhances caveolaemediated albumin transcytosis through human endlora balance of mothers milk in mastitis during lactation many trials estimating the efficiency of lactobacillus fermentum in prevention and treatment of acute and subacute mastitis have been carried out the results of them open a new door in front of us in the treatment of these conditionstreatment with probiotics instead of antibiotics | MEDAL |
EB simplex ebs is an autosomal dominant disorder characterised by intraepidermal blistering of the skin two families with webercockayne ebs have been analysed for linkage to keratin gene loci in the first family linkage was found to chromosome markers flanking the keratin gene ds zmax theta cola zmax theta and markers near the keratin gene on chromosome were excluded ds z less than theta cola z less than theta in contrast the second family showed linkage to the region containing the keratin gene ds zmax theta cola zmax theta and was not linked to the keratin gene ds z less than theta the webercockayne form of ebs is genetically heterogeneous with linkage to different keratin gene loci | MEDAL |
image digitalization can be performed in several ways equalization of the xray beam scanning equalization radiography and advanced multiplebeam equalization radiography digital fluorography use of linear computed tomography detectors digitalization of radiographic films and memory screens phospholuminescent screens use an xray receptor which is able to store the xray energy this latent SE is then extracted and can be processed to obtain images with matrices ranging between x and x several types of image processing systems can be used depending on the pathology investigated the blurred mask substraction method is the most widely used the first clinical results demonstrate a reduction in patient irradiation and performances equal to or better than those of standard xrays | MEDAL |
for biotherapeutics and vaccines potency is measured in a bioassay that compares the concentrationresponse curves of a new batch to that of a reference standard acceptable accuracy and precision of potency measurement is critical to the manufacturing of these products these characteristics of a bioassay are typically assessed in a procedure that is carried out with samples spanning the acceptable range for the product during early development however a full validation study such as that which is carried out in late OD can be costly as it relates to the likelihood of eventual program success for these reasons the laboratory may look for alternative ways to ensure the validity of the bioassay across a range that will support product OD one such alternative combines information from a reduced procedure using only reference standard and RP concentrationresponse data sets together with computer simulation to estimate missing relative potency values across the desired range fits to the reduced dataset provide estimates of bioassay model parameters such as those for an sshaped potency assay that follows a fourparameter logistic relationship along with estimates of their variancecovariance structure and independent experimental unit eg welltowell or animaltoanimal errors using bayesian markov chain monte carlo modeling the predictive distribution of the concentrationresponse data for the desired levels of relative potency is generated results from use of the reduced procedure are compared to results calculated from a full dataset in monte carlo simulation and in a motivating example | MEDAL |
the purpose of this study was to establish the firsttrimester screening for down syndrome ds in estonia and to evaluate the potential of a contingent screening in the population of Pr women a prospective cohort study included nonselected pregnancies during the programme of firsttrimester screening for ds in a year period at a single centre the following screening tests were evaluated measurement of nuchal translucency nt and seral feeding tube in a pediatric population these tubes have been used in the AD population with success but to the authors knowledge there have been no reports of its use in the pediatric age group | MEDAL |
a yearold woman was diagnosed with pancreatic head CA with hepatic i.a. invasion by multidetector computed tomography mdct T3 courses of gemcitabine plus s neoadjuvant therapy the RT size was not diminished however the RT marker ca level was decreased to less than of its initial level pancreaticoduodenectomy combined with hepatic artery resection was performed and an endtoend anastomosis was made between the common and PHA to reconstruct the HA the pathological examination indicated adenosquamous carcinoma no vascular invasion and negative margin status and the efficacy of chemotherapy was classified as gradeâ ±b using evans classification usually pancreatic head CA with HA invasion is considered unresectable due to its high morbiditymortality and poor prognosis however with the recently developed surgical strategy and appropriate therapeutic interventions such as a combination of neoadjuvant chemotherapy and resectionreconstruction of the hepatic artery a curative T0 can be feasible for locally T3 pancreatic head CA | MEDAL |
oxodelta tetrahydrocannabinol was oxidized to delta tetrahydrocannabinoloic acid by mouse hepatic microsomes the oxygenation mechanism in the reaction was confirmed by the incorporation of oxygen from molecular oxygen into delta tetrahydrocannabinoloic acid the oxygenation of aldehyde to carboxylic acid represents a novel mechanism in biological oxidation of aldehyde to carboxylic acid | MEDAL |
twenty mammary CL node samples were collected from cattle on a farm in the republic of korea these cattle were serologically negative for brucella by tube agglutination test ⤠and SAT ⤠out of lymph node samples two samples were positive for brucella growth on brucella agar as well as blood agar tests for urease hydrogen sulphide and reactions against monospecific sera a and m indicated that these two isolates no and belong to the genus brucella genus specific amos abortus melitensis ovis suis and bruceladder multiplex PCR reaction pcr assays confirmed the brucella isolates as either a b abortus or a b canis CS this is the first report of the occurrence of a b canis infection in cattle in korea more survey data are needed to determine whether b canis is a significant aetiology in the cases of cattle brucellosis in korea | MEDAL |
in acute myeloid leukemia aml receptor IMT kinase ligands promote growth and survival and contribute to amlassociated marrow neoangiogenesis we have tested simultaneous inhibition of VE growth factor FB growth factor and plateletderived growth factor receptor signaling by novel indolinone derivatives using myeloid including HL-60 cell lines EDC inhibited colony formation of all cell lines in a dosedependent fashion GABA concentrations for of the colony formationsurvival ic for bibf were nmoll for of or nmoll for of and nmoll for of leukemic cell lines with one cell line being resistant in the dose range nmoll bibf was less ERP with of leukemic cell lines being resistant within the dose range nmoll testing of myeloid d cells transfected with empty vector wildtype flt or flt carrying an internal tandem duplication mutation revealed higher resistance for the internal tandem duplication mutant these effects of the compounds were associated with inhibition of IMT phosphorylation and the MAP kinase pathway furthermore both compounds induced apoptosis in the sensitive cell lines in monomac cells the EDC had a direct proapoptotic effect that was increasing the proapoptotic effect of betadarabinofuranosylcytosine the data provide a rationale for clinical evaluation of these tyrosine kinase inhibitors in aml | MEDAL |
ethanol is the most abused psychoactive substance accordingly to world health organization ethanol ranks among the top five risk AF for disease disability and death millionyear throughout the world this manuscript highlights and critically analyses clinical and forensic signs related to hepatoxicity of ethanol that may lead to suspected of abuse namely steatosis jaundice cirrhosis hemorrhoids esophageal varices caput medusae ascites petechiae ecchymoses splenomegaly hemochromatosis xanthelasma nutritional deficiency testicular atrophy gynecomastia and dilated congestive cardiomyopathy are discussed and related to the toxic mechanism of ethanol | MEDAL |
we describe a new surgical technique adopted for the repair of stanford type a aortic dissection in order to minimize the risk of malperfusion caused by retrograde flow during CP bypass we avoid FA cannulation on the hypothesis that it is best not to interfere with the hemodynamics of the dissection we cannulate the dissected ascending aorta in either the true or false lumen we here report cases of successful surgical treatment of stanford type a aortic dissection in both cases the false lumen was cannulated under deep HCA without clamping the aorta while the patient was cooling a mm goretex side arm was sutured to a dacron graft prosthesis repair of the aortic arch was carried out st the aortic cannula was inserted into the goretex side arm the tubular prosthesis was crossclamped and cardiopulmonary bypass was reinstituted after this the aortic bulb was repaired as usual and the tubular prosthesis was sutured to the bulb no postoperative CBF complication occurred our experience must be confirmed by more cases and a longer follow up | MEDAL |
the epsteinbarr virus ebv has been demonstrated in association with cases of hodgkins disease hd indicating that in at least in some cases ebv may play a pathogenic role in the development of hd to determine the prevalence of ebv in hd in a mexican adult population we studied formalinfixed andor b paraffin embedded samples of patients with hd by immunoperoxidase in situ hybridization was done in of the cases we analyzed the presence of the latent membrane protein lmp and ebvspecific dna sequences reedsternberg cells and mononuclear variants were positive for lmp in cases lmp staining was found both on the cell surface andor within the cytoplasm with enhancement in the golgi area the lmp was found in the single case of diffuse LP hd in cases of NS in cases of mixed cellularity and in all eleven cases of lymphocyte depleted hd no ebvspecific dna sequences were found by in situ hybridization our results show a higher association of ebv in our population compared to the approximately reported in developed countries all histologic subtypes of hd in mexico appear to be strongly associated with ebv in contrast to the strong association with only mixed cellularity seen in western populations the high prevalence of ebv in hd in mexico may be a function of histology ethnic groups socioeconomic AF andor geography | MEDAL |
pain often is inadequately treated due in part to reluctance about using opioid analgesics and fear en on patients from the emergency department ed prepacs minutes postpacs T2 p and for examinations taken on patients in the medical intensive care unit micu prepacs T2 postpacs T2 p the interval from image dispatch until report dictation shortened significantly after the introduction of pacs in the ed prepacs minutes postpacs T2 p and in the outpatient department opd prepacs minutes postpacs minutes p simple least squares regression showed a significant relationship between daily patient volume and the daily median time until report dictation f p pacs slowed technologists by prolonging the qualitycontrol procedure radiologist workflow was shortened or not affected efficiency is dependent on patient volume and workflow improvements are due to a shift from batch to online reading that is enabled by the ability of pacs to route enough examinations to keep radiologists fully occupied | MEDAL |
CAF including the left trunk and left circumflex is uncommon we present a yearold male patient with a giant left main trunk and left circumflex artery to right ventricle fistula which is diagnosed by transthoracic echocardiography and coronary CTA in this paper the case report is to provide a better understanding of clinical characteristics for this disease | MEDAL |
the relationship between various types of fiber and colorectal cancer risk was investigated using data from a casecontrol T0 conducted between january and june in italy the T0 included cases of incident histologically confirmed colorectal cancers colon cancers and rectal cancers admitted to the L1 teaching and GA hospitals in the study Az and controls with no PH of CA admitted to hospitals in the same catchment areas for acute nonneoplastic diseases dietary habits were investigated using a validated food frequency questionnaire odds ratios ors were computed after allowance for age sex and other potential confounding AF including physical activity and protein fat and carbohydrate intake fiber was analyzed both as a continuous VL and in quintiles for most types of fiber the or of colon and rectal cancers was significantly below and no appreciable differences emerged between the two when the unit was set at the difference between the upper cutpoints of the fourth and first quintile ie the th and th percentiles the ors for CC were for total fiber determined by the englyst method as nonstarch PSs for soluble noncellulose polysaccharides ncps for total insoluble fiber for cellulose for insoluble ncps and for lignin when fiber was classified according to the source the or was for vegetable fiber for fruit fiber and for cereal fiber the ors were similar for the two sexes and the strata of age education PCS activity family PH of CC and energy intake likewise no appreciable differences emerged when subsites of the colon and rectum were investigated separately this study provides additional support for a protective and independent effect of fiber on colorectal CA particularly for cellulose and soluble ncps and of fiber of vegetable or fruit origin | MEDAL |
caffeine has been shown to reduce legmuscle pain during submaximal cycle ergometry as well as in response to eccentric exercise however less is known about its analgesic properties during nonsteadystate highintensity exercise the primary aim of this study was to examine the effect of doses of caffeine on leg pain and rating of RPE rpe during repeated bouts of highintensity exercise fifteen AS men age ± yr completed bouts of repetitions of allout knee extension and flexion of the dominant leg at a contraction velocity equal to °s before each trial subjects abstained from caffeine intake and intense exercise for hr over days separated by hr subjects ingested of treatments mgkg or mgkg of anhydrous caffeine or placebo in a randomized singleblind counterbalanced crossover design legmuscle pain and rpe were assessed during and T3 exercise using established categorical scales across all treatments pain perception was significantly increased p during exercise as well as from bout to yet there was no effect p of caffeine on pain perception or rpe various measures of muscle function were improved p with a mgkg caffeine dose vs the other treatments in the mgkg trial it is plausible that subjects were able to perform better with similar C2 of pain perception and exertion | MEDAL |
six patients with anomalous origin of one pulmonary artery from the ascending aorta were reviewed four had anomalous origin of the RA pulmonary artery and two had anomalous origin of the left pulmonary i.a. from the ascending aorta two of these six patients had tetralogy of fallot two patients died in the first month of life no changes in the pulmonary vasculature were seen at necropsy corrective surgery was attempted in two patients with associated tetralogy of fallot when they were two years old but both died at necropsy there was severe pulmonary AVD in the lung supplied by the anomalous pulmonary artery but no pulmonary V1 hypertensive changes in the lung supplied by the pulmonary artery from the right ventricle two recent patients underwent successful anastomosis of the anomalous pulmonary i.a. to the main pulmonary artery at three months and one month and three weeks of age respectively intraoperative lung biopsy in the latter patient showed early changes in both lungs both echocardiography and cardiac catheterisation were used in the diagnoses systemic or suprasystemic pressures were found in the pulmonary artery arising from the RA ventricle as well as the anomalous pulmonary artery in the three patients without tetralogy of fallot anomalous origin of a pulmonary artery from the ascending aorta is a distinct entity and differs from other aortopulmonary arterial connections early surgical MI is recommended in all patients including those patients with associated tetralogy of fallot because of the risk of rapid development of irreversible pulmonary AVD | MEDAL |
an infant with congenital syphilis associated with transient disturbances of lipoprotein metabolism is reported the dominant clinical sign was hepatosplenomegaly laboratory investigation upon admission revealed hyperimmunoglobulinemia and hyperchylomicronemia T3 the administration of penicillin the chylomicronemia ceased but an increase of very LD lipoprotein fraction was observed as the infant recovered all the laboratory findings returned to normal hyperchylomicronemia was attributed to hyperimmunoglobulinemia absorption of immunoglobulins to lipoproteins can inhibit lipoprotein lipase activity the increase in the very LD lipoprotein fraction was probably caused by the increase in serum lipoprotein production and the decrease in lipoprotein clearance that are frequently seen in patients with infectious diseases | MEDAL |
coronary artery bypass grafting cabg was first used in the late s this revolutionary procedure created hope among ischemic heart disease patients multiple conduits are used and the golden standard is the LIMA to the LAD i.a. although all approaches were advocated by doctors the use of saphenous vein grafts became the leading RPA used by the majority of cardiac surgeons in the s the radial artery VG was introduced at the same time but was not as prevalent due to complications it was reintroduced into clinical practice in the procedure was not well received initially but it has since shown superiority in patency as well as LT survival T3 cabg this review provides a summary of characteristics technical features and patency rates of the RA VG in comparison with venous conduits current studies and research into RA grafts and saphenous vein grafts for cabg are explored however more studies are required to verify the various findings of the positive effects of CABG with the help of radial arteries on mortality and longlasting patency | MEDAL |
to evaluate the influence of sterilization treatment on continuous carbonfiber reinforced polyolefin composite cfrp so as to provide exp reference for selection of sterilization method for cfrp | MEDAL |
we report a case of fertility preservation using randomstart controlled ovarian stimulation cos intracytoplasmic sperm i.t. icsi and embryo cryopreservation in a patient with early pregnancyassociated breast CA a yearold nulliparous woman at weeks of gestation was diagnosed with estrogen receptor er positive progesterone receptor pr positive and human epidermal growth factor receptor her negative infiltrating intraductal carcinoma urgent neoadjuvant chemotherapy was deemed necessary and the patient decided to terminate the pregnancy randomstart cos was initiated days after pregnancy termination using a letrozolebased protocol the beta human chorionic gonadotropin level on the day of cos start was miuml twentynine oocytes were retrieved T3 days of cos seventeen oocytes underwent successful fertilization and blastocysts were CP the patient subsequently initiated neoadjuvant chemotherapy with her oncologist the current case highlights the feasibility of randomstart cos and embryo cryopreservation for fertility preservation immediately T3 the termination of an early pregnancy in a patient with Pa breast cancer | MEDAL |
EPI plays a key role in modulating tissue factordependent blood coagulation we have studied IB of radioiodinated recombinant extrinsic pathway inhibitor repi to cultured cell surfaces repi in the absence of added reactants bound to a limited extent to three cell lines studied IB of repi to two cell lines possessing surface tissue factor but not to a cell L1 lacking surface tissue factor was markedly increased in the presence of both factor viia and factor xa and calcium ions moreover some increased tissue factordependent IB was also demonstrated with factor viia CT binding isotherms of repi to factor viiatissue factor obtained with an ovarian HEp-2 were hyperbolic scatchard plots indicated the following a kd value of nm and sitescell when factor xa was present a kd value of nm and sitescell when factor xa was absent in PET studies high concentrations of repi eg nm were found to inhibit factor viiatissue factorcatalyzed PR of AP from tritiated factor ix in the absence of factor xa whereas factor xa was thus shown not to be required for repi to inhibit factor viiatissue factor catalytic activity its presence markedly enhanced repis inhibitory CF since the local concentration of EPI achieved at a site of tissue injury is unknown the physiologic significance of the observation of extrinsic pathway inhibitorinduced inhibition of factor viiatissue factor activity in the absence of factor xa is not clear however factor xaindependent inhibition could play a significant role when C1 doses of repi are po in exp studies of thrombosis | MEDAL |
nursing facility administrators must find new and innovative ways to meet the training needs of their staff the authors faced the challenge of teaching nursing facility staff about fire safety using computerbased training that had been adapted from a printbasedinstructorled il program this article discusses the effectiveness of the computerbased cb training as compared to the effectiveness of the traditional il format the B6 and il versions of a fire safety training program were presented to staff of a nursing facility the participants were randomly assigned to the cb il or control groups the control group completed a pretest and posttest but received no training until the study was completed both the B6 and il CG significantly increased their knowledge scores from pretest to posttest and both significantly outperformed the control group how the participants responded to the B6 training was also important staff reported they enjoyed the B6 training and had no difficulty using the computers computerbased training can be an ERP alternative training technique for this population | MEDAL |
we conducted a comprehensive review of studies assessing the efficacy and tolerability of psychostimulants for adhdlike PS in individuals with autism spectrum disorder encompassing autism disorder aspergers syndrome and PDDs not otherwise specified pubmed ovid embase web of science eric and cinhal were searched through january from a pool of potentially relevant references citations studies were retained as pertinent four of the included studies had a randomized controlled design most of the studies assessed methylphenidate immediate PR despite interstudy heterogeneity taken together the results of the selected reports suggest that psychostimulants may be ERP for adhdlike symptoms in autism spectrum disorder individuals the most common adverse events reported in the included trials were appetite reduction sleeponset difficulties irritability and emotional outbursts we discuss future directions in the field including the need for trials assessing more ecological outcomes and combined treatment strategies tailored to the TPS individual features | MEDAL |
to investigate diagnostically significant for atherosclerotic plaques asp of various types parameters of activity of matrix metalloproteinases mmp mmp mmp in homogenates as well as tissue expression of mmp mmp and collagen type iv | MEDAL |
insulin is a major disease determinant in type diabetes type diabetes and related disorders the role of variations in the expression of the INS has been proposed in genetic susceptibility to the three pathological conditions in humans in contrast to humans rodents express two proinsulin isoforms one isoform proinsulin is expressed exclusively in islets the second proinsulin is expressed in islets and in other tissues especially the thymus we took advantage of the expression of these two isoforms to introduce a null proinsulin allele in nod mice and to evaluate the consequence of a R2 of proinsulin mRNA on the development of type diabetes on the nod genetic background nu/+ nod mutant mice carrying a null PI mutation showed an increased incidence of type diabetes at successive backcross generations plasma glucose and insulin C2 were identical in prediabetic mutant and in wildtype mice at weeks of age R2 in insulin mRNA is hypothesized to interfere with diabetes OD at both the islet and the thymus level | MEDAL |
secretoneurin sn was detected in the AQ humor ah of patients treated topically with tobramycine eye drops alone or tobramycine and cyclosporine a tobramycine and diclofenac or tobramycine and rimexolone the levels of the peptide were found to be higher in the uninflamed human than in the rb aqueous humor which may be the result of species differences andor agerelated circumstances furthermore they are approximately one hundred times higher than those of classical neuropeptides indicating PR from nerve SF andor secretion from nonpigmented CE cells despite a slight tendency by rimexolone to decrease the C2 there was no significant effect seen for either of the drops it must be considered that aminoglycosides are known to have toxic side effects and that they can influence the C2 of sn which may be not diminished by low topical doses of CSs or nonsteroidal antiinflammatory drugs the high levels of the peptide are of relevance and may indicate a significant role of secretoneurin in the anterior segment of the eye this should encourage performing functional studies | MEDAL |
correlation of a chest roentgenogram and a RN scan facilitated the interpretation of a CL scan with a defect in the dome that was due to an extrinsic compression and photon attenuation by a M1 tumor in the right lung base | MEDAL |
dyschromatosis symmetrica hereditaria dsh also called reticulate acropigmentation of dohi is a pigmentary genodermatosis of AD inheritance characterized by a mixture of hyperpigmented and hypopigmented macules distributed on the dorsal aspects of the hands and feet to determine the gene responsible for this disease we performed a genomewide search in three families with dsh and mapped the dsh locus to chromosome q the mutations involved in causing dsh have been identified in the gene that encodes doublestranded rnaspecific adenosine deaminase dsrad as the disease gene | MEDAL |
for determination of sacroiliitis frequency among natives of chukotka peninsula a crossover epidemiological T0 was conducted a total of subjects aged years and older were examined of them had LBP xray of the pelvis was made in of patients it was found that SI incidence in chukotka natives makes up there were marked differences in sex CSD in males in females rr out of chukotka natives with LBP had ankylosing spondylitis of patients with sacroiliitis a prospective study of patients with sacroiliitis recorded development of ankylosing spondylitis in of the cases years after the disease ON | MEDAL |
in the past decade evidence has accumulated showing that there are stereospecific opioid drug receptors located on the surface CM of neurones and skeletal muscle MF which can block action potentials when opioid drugs are applied to the cells the nature of this evidence and the difficulties involved in this area of investigation are discussed in detail two different mechanisms have been described for this depression of excitability one a direct blocking action on sodium channels or the calcium channels in the case of cells with calcium action potentials and the other a stimulation of membrane gK which results in hyperpolarization and increased membrane conductance both of which decrease excitability for the most part these different mechanisms seem to prevail in different cell types as will be discussed some other points discussed are as follows first in higher doses or concentrations opioids produce a local anestheticlike effect which cannot be antagonized by opioid antagonists next the opioid antagonists which are easily easily available and commonly employed NC from antagonists to agonists as their concentration is increased and finally the evidence required for the demonstration of stereospecific or is considered in some detail | MEDAL |
a yearold woman with a history of BE and ventricular septum defect repair was referred for DUE of a mass in the RA midlung field a contrastenhanced computed tomography scan of the chest showed an aneurysm of the right lateral pulmonary artery the aneurysm was considered to be mycotic in origin the aneurysm was treated by coil embolization using detachable coils measuring cm in overall length | MEDAL |
hepatitis b surface antigen is the L1 protein of the virion envelope and is also independently secreted from INF cells as a subviral particle composed exclusively of hbsag and hostderived lipid similar particles are efficiently assembled and secreted by cultured rat cells transfected with the gene for hbsag in contrast to such cultured cells xenopus oocytes microinjected with hbsag mrna secrete less than of newly synthesized hbsag polypeptides we have examined the hbsag biosynthetic intermediates in such oocytes and provide evidence that the impaired secretion of hbsag is due to a discrete block in the assembly of lipoprotein particles | MEDAL |
solid pseudopapillary neoplasm a lesion of uncertain cellular differentiation is an unusual RT of the pancreas with an indolent clinical course that typically arises in young females we report a case of solid pseudopapillary neoplasm arising in a yearold adolescent girl who presented with progressive abdominal pain the patient underwent surgical resection of an à à cm pancreatic mass that displayed the usual histologic features of a solid pseudopapillary neoplasm in addition to prominent nuclear atypia increased proliferative index and extensive CN these unusual histologic findings are rare and are of particular interest owing to the dramatically decreased survival time displayed in this case although precise pathologic criteria suggesting a high risk for aggressive behavior of solid pseudopapillary neoplasms are uncertain recognition of the unusual pathologic features displayed in this case may be useful in the prediction of potentially more aggressive neoplasms that portend a poorer prognosis | MEDAL |
TTE tte is used to estimate pulmonary artery systolic pressure but an adequate tricuspid regurgitation velocity trv needed to calculate pulmonary artery SP is not always present it is unknown whether the absence of a measurable trv signifies normal pulmonary CAP | MEDAL |
the aim of this T0 was to investigate closely the nature of premalignant lesions that occur in prophylactically removed breast tissue from patients at hereditary high risk of breast CA breast tissues obtained from patients who underwent PM pm because of a hereditary high risk of breast cancer and control tissues from agematched healthy controls who underwent breast reduction surgery were screened for premalignant lesions premalignant and malignant lesions were more frequent p in pm samples than in controls interestingly lobulitis defined as more than lymphocytes andor PCs per lobule in more than one section in morphologically normal lobules was encountered in of pm patients in contrast to only of controls p preliminary observations indicate a predominance of tcells in these infiltrates in PA with the already known frequent presence of lymphocytic infiltration in hereditary ductal in situ and infiltrating ductalmedullary carcinomas this novel finding implies an immune reaction to an as yet unidentified antigen frequently present in women at hereditary high risk of breast CA possibly as part of an early carcinogenic event | MEDAL |
hyperlipidemia in the GP has been linked to the development of chronic kidney disease with both oxidative and endoplasmic reticulum stress implicated physiological C2 micromoll of saturated fatty acids such as palmitic acid pa cause cytotoxicity in vitro we investigated cell type and stimulusspecific signaling pathways induced by pa in renal proximal tubular cells and whether oxidative stress leads to er AS or vice versa and which pathways predominate in signaling for painduced apoptosis and CN nrke cells were incubated with pa or hydrogen peroxide ho combined with sp which blocks cjun nterminal kinase jnk activation salubrinal which maintains eukaryotic initiation factor alpha in its phosphorylated state and the antioxidant euk a superoxide dismutase mimetic with cat we found that i pa causes both oxidative and er AS leading to apoptosis which is mediated by phosphorylated jnk ii oxidantinduced apoptosis generated by ho involves er AS signaling and chop expression iii the er stress mediated by pa is largely independent of oxidative AS iv in contrast the apoptosis produced by pa is mediated partly via oxidative stress pamediated cell signaling in renal nrke cells therefore differs from that identified in neuronal hepatic and pancreatic beta cells | MEDAL |
in the past few years there has been remarkable progress in knowledge of the structures and organization of the protein complexes of photosynthetic CM however static structures do not tell the whole story photosynthetic membranes like other biological CM are dynamic systems recent technological advances are making it increasingly easy to probe the dynamics of photosynthetic membranes using fluorescence recovery after photobleaching here we explain the potential and the limitations of the technique | MEDAL |
there are many treatment options for female SD fsd with the optimal therapy depending on the etiology of the problem the cause of SD is multifactorial and may include psychological problems such as depression or anxiety disorders conflict within the relationship partner performance and technique issues relating to prior abuse medical illness medications fatigue stress or gynecological problems that make sexual activity uncomfortable the role of low androgen concentrations in fsd is gaining increasing attention available therapeutic options include adjusting medications counseling treating depression or anxiety reducing stress and fatigue sex therapy devices estrogen therapy for genitourinary atrophy and possibly vasoactive substances although no androgen therapies are currently approved by the food and drug administration for fsd they are being used in clinical practice and early CT results suggest that they may be both ERP and safe in the treatment of fsd specifically low libido androgen therapy should be considered primarily in women who have a physiological reason for reduced androgen concentrations including aging hypopituitarism oophorectomy or adrenal insufficiency products in use include oral methyltestosterone and dehydroepiandrosterone topical testosterone ointment and testosterone implants and injections products available for men including skin patches and gels are currently being studied at doses AGA for women possible risks include hirsutism acne liver dysfunction lowering of the voice adverse lipid changes virilization of a female fetus and as androgens are aromatized to estrogens potentially the risks of ET | MEDAL |
guanidino EDC gcs such as creatine phosphocreatine GAA creatinine methylguanidine GSA γguanidinobutyric acid βguanidinopropionic acid guanidinoethane sulfonic acid and αguanidinoglutaric acid are present in the mammalian brain although creatine and phosphocreatine play important roles in SE homeostasis in the BB accumulation of gcs may induce epileptic discharges and convulsions this review focuses on how physiologically important andor neurotoxic gcs are distributed in the brain under physiological and pathological conditions transporters for gcs at the bloodbrain barrier bbb and the bloodcerebrospinal fluid csf barrier bcsfb have emerged as substantial contributors to gcs distribution in the brain creatine transporter crtsolute carrier slc a expressed at the bbb regulates creatine concentration in the brain and represents a major pathway for supply of creatine from the circulating blood to the BB crt may be a key factor facilitating bloodtobrain guanidinoacetate transport in patients deficient in sadenosylmethionineguanidinoacetate nmethyltransferase the creatine biosynthetic enzyme resulting in cerebral accumulation of guanidinoacetate crt taurine transporter tautslca and OCT octslca expressed at the bcsfb are involved in guanidinoacetic acid or creatinine efflux transport from csf interestingly bbb efflux transport of gcs including GAA and creatinine is negligible though the bbb has a variety of efflux transport systems for synthetic precursors of gcs such as amino acids and neurotransmitters instead the bcsfb functions as a L1 cerebral clearance system for gcs in conclusion transport of gcs at the bbb and bcsfb appears to be the key determinant of the cerebral levels of gcs and changes in the transport characteristics may cause the abnormal CSD of gcs in the brain seen in patients with certain neurological disorders | MEDAL |
glomerular sclerosis of diverse etiologies is characterized by MM accumulation with transforming growth factorbeta tgfbeta an important pathogenic factor the gtpase rhoa mediates tgfbetainduced matrix accumulation in some settings here we study the role of the membrane microdomain caveolae in tgfbetainduced rhoa activation and fibronectin upregulation in mesangial cells mc in primary rat mc tgfbeta time dependently increased rhoa and downstream rho kinase activation rho pathway inhibition blocked tgfbetainduced upregulation of fibronectin transcript and protein tgfbetainduced rhoa activation was prevented by disrupting caveolae with cholesterol SD and rescued by cholesterol repletion compared with wild types rhoarho kinase activation was absent in mc lacking caveolae reexpression of caveolin and caveolae restored these responses phosphorylation of caveolin on y effected by src kinases has been implicated in signaling responses overexpression of nonphosphorylatable caveolin ya prevented tgfbetainduced rhoa activation tgfbeta also activated src and its inhibition blocked rhoa activation furthermore tgfbeta led to association of rhoa and caveolin this was prevented by src or tgfbeta receptor i inhibition and by caveolin ya overexpression last fibronectin upregulation by tgfbeta was blocked by src inhibition not seen in caveolin KO mc and restored by caveolin reexpression in the latter tgfbetainduced collagen i accumulation also required caveolae tgfbetamediated smad activation however did not require caveolae we conclude that rhoarho kinase mediates tgfbetainduced fibronectin upregulation this requires caveolae and caveolin interaction with rhoa interference with caveolincaveolae or rhoa signaling thus represents a potential target for the treatment of fibrotic renal disease | MEDAL |
the el niño southern oscillation enso is a complex climate phenomenon occurring in the pacific ocean at intervals of years the term refers to fluctuations in ocean temperatures in the tropical eastern pacific ocean el niño the warm phase of enso and la niña the cool phase of enso and in atmospheric pressure across the pacific basin southern oscillation this weather pattern is attributed with causing climate change in certain parts of the world and is associated with disease outbreaks the question of how enso affects skin and skinrelated disease is relatively unanswered we aimed to review the literature describing the effects of this complex weather DP on skin el niño has been associated with increases in the occurrence of AK tinea pityriasis versicolor miliaria folliculitis rosacea dermatitis by paederus irritans and paederus sabaeus and certain vectorborne and waterborne diseases such as DF leishmaniasis chagas disease BFV and leptospirosis and with decreases in the occurrence of dermatitis scabies psoriasis and papular urticaria la niña has been associated with increases in the occurrence of varicella hand foot and mouth disease and ross river virus in certain Az and decreases in viral warts and leishmaniasis reports on the effects of enso on skin and skinrelated disease are limited and more studies could be helpful in the future | MEDAL |
shortage of organs is a major problem in kidney transplantation and requires novel strategies to increase the number of Tx to reduce the shortage of kidneys we have proposed transplantation of two halves of one kidney into two recipients hemirenal transplantation hrt and have shown its feasibility in pig and human kidneys however reduced renal mass can lead to progressive renal failure in rodents and can reduce the longevity of kidney transplants in humans recent studies suggest that derangement of angiogenesis plays a role in the progressive renal failure T3 reduction in renal mass in rodents however since the renal physiology of rats is different from that of large animals we studied angiogenesis in RRM transplants in pigs and determined if the reduction in renal mass has the same effect in C1 animals as that in rodents | MEDAL |
the response to selection for leaf proteins was studied during three selection cycles selection for high total nitrogen content showed heritability and the C2 of both ribulose bisphosphate carboxylase oxygenase rubisco and cytoplasmic protein were strongly under nuclear dna control high and low protein content were correlated with cp area although the amounts of nuclear dna were similar the ratio of rubiscodna and chlorophylldna changed during the selection process it can be concluded that the C2 of rubisco achieved in mature plants of m sativa are under nuclear dna control the possible involvement of small S1 ssu genes in controlling these levels is discussed | MEDAL |
a decline in t cell function accounts for many of the observed agerelated deficient immune responses TPS antibody response to many antigens requires t cell cooperation and deficient antibody response to such antigens has been demonstrated with aging in an effort to assess the potential reconstitutive capacity of thymosin fraction in vitro antitetanus antibody production was measured in tetanus toxoid boosterimmunized young and old volunteers young and old volunteers were immunized with tetanus toxoid and plasma antitetanus antibody and in vitro lymphocyte production of antitetanus antibody was measured plasma antitetanus antibody response was significantly greater in the young in vitro antitetanus antibody synthesis was negligible prior to immunization and peaked in cultures established week T3 immunization from both young and old when thymosin fraction was added to the cultures however there was a doserelated enhancement of antibody synthesis in of from the group of elderly volunteers but only of from the younger group our data indicate that specific antibody response is deficient in the elderly but can be enhanced in vitro by thymosin a future clinical trial of thymosin as an adjuvant to active immunization for the elderly is warranted | MEDAL |
the aim was to investigate whether the selfestimation of oral and general health is correlated and related to clinical parameters for dental health furthermore to investigate the influence of socioeconomic factors on the selfassessment of oral and general health during a dental health survey was performed in the community of gävle located in central sweden subjects randomized from the GP of gävle adult population were invited to participate seven hundred and fortyeight individuals answered a questionnaire regarding their health and of these subjects participated in a dental examination selfestimated oral and general health was correlated p r and individuals who perceived their oral health as bad had more decayed surfaces surfaces with secondary caries fewer teeth and more BOP than those with good estimated oral health p for all in a LR analysis with selfestimated oral health as the dependent variable was related to the independent variables nt dft selfestimated GA health and age were related to selfestimated oral health but not to income or educational level however subjects with low disposable income and low education level had significantly more clinical caries and fewer teeth than subjects with high income or a high educational level | MEDAL |
an experimental chronic infection was induced in inbred ag and cba mice by repeated administration of four cytopathogenic agents isolated from human cases of balkan endemic nephropathy ben the slight humoral and CMI responses to the ben agents recorded in ag mice were associated with autoimmunity and hypersensitivity phenomena in contrast the normal intense immune response observed in cba mice was not accompanied by any immunopathological changes in both mouse lines the chronic infection with human ben agents led to a secondary immune deficiency against sheep red blood cells or tuberculin | MEDAL |
to explore the differences in baseline respiratory sinus arrhythmia rsa between children with fetal alcohol spectrum disorder fasd and TD children tdc and to investigate whether children with fasd have the capacity to engage in a brief mindfulness exercise | MEDAL |
although kidney transplantation is considered to be more desirable than dialysis in terms of costeffectiveness and patients quality of life there have been very few cases of Tx in japan this study was conducted to compare the costeffectiveness of dialysis and kidney transplants using disabilityadjusted life years dalys as an indicator of effectiveness most data necessary for the dalys analysis were obtained from publications the disability weights for dialysis patients and kidney SPK patients were estimated based on a questionnaire emailed to medical officials of the japanese government expected duration of treatment was estimated from the survival rates of dialysis patients and the graftsurvival rates of SPK patients using the weibull MM method the cost of dialysis and livingrelated donor lrd transplant included only medical expenditures and neglected all other costs and the cost of cadaveric donor cad transplant included the budget for organ procurement and CSD in addition to medical expenditures the analysis showed that dialysis averted dalysyear livingrelated donor SPK averted dalysyear and cad transplant averted dalysyear the CER ce ratio was thousand yendaly for dialysis thousand yendaly for lrd SPK and thousand yendaly for cad transplant these results could be used for the decision making of the government on what resources should be allocated to the promotion of kidney transplantation also the methodology used in this T0 can be applied to CEA of other organ transplants | MEDAL |
we evaluated the AF affecting closure and postoperative VA as well as complications among idiopathic macular hole surgery cases comprising eyes in patients almost all the surgeries were combined with simultaneous intraocular lens surgery triple surgery in some cases the standard method was accompanied by ILM peeling around the MH or abrasion of RPE at the base of the macular holes we found that male gender and short eye axial length were associated with closure and postoperative visual acuity although the frequency of IP retinal tears during surgery was high the frequency of postoperative retinal detachment was less than the reopening frequency was about among all cases and was highest among eyes that underwent the abrasion method there were no other significant complications ILM peeling is effective for treatment of cases with unfavorable preoperative conditions however the standard method is sufficiently ERP for cases with favorable preoperative conditions further analysis is required to evaluate postoperative visual function by methods other than visual acuity further study of internal limiting membrane peeling as a treatment alternative is also required | MEDAL |
nnmr spectra and EC50 times for dipalmitoylphosphatidylcholine and three analogs were obtained in both the liquid crystal and gel phases the analogs either changed the po to n ch distance pn within the headgroup by increasing the number of ch CG from two in the phosphocholine headgroup pn to six in the phosphonnntrimethylhexanolamine headgroup pn or replaced the ester linkages to the hydrocarbon chains with either linkages pnmr spectra were obtained for the four samples in the liquidcrystal phase the n and pnmr spectra and n relaxation times all indicate that increasing the pn distance within the headgroup causes changes in both the average orientation of the cn bond and its dynamics the nnmr spectra provide evidence for a NC in orientational order of the headgroup as a result of changing the linkage to the acyl chains on the other hand the EC50 time measurements indicate that the molecular motion for the headgroup is independent of the type ofin within min rats were deeply unconscious and muscles CR relaxed while shaking of limbs continued until REC to min later or death with mumol or less none of the rats became comatose but the shaking of limbs was present the comainducing dose of PH was reduced by to with simultaneous injection of subcoma doses of nh or oa and by to with simultaneous dmds leads to methanethiol conversely a subcoma dose of PH reduced the comainducing doses of nh oa and dmds by approximately to thus phenol which accumulates in human hepatic failure induces coma by itself in rats and acts synergistically with other hepatic failure toxins | MEDAL |
this is the report of a female infant ten weeks of age who was admitted to our hospital with hyperpyrexia HA and disseminated intravascular coagulation the further course of the disease was characterized by continuing hemolysis resulting in severe normochromic normocytic anemia unrelenting disseminated intravascular coagulation increasing hepatosplenomegaly with hyperbilirubinemia and ascites no causative infectious organism could be identified the infant died at the age of weeks from RI autopsy revealed massive hepatosplenomegaly ascites and bilateral pneumonia histologic DUE demonstrated lymphohistiocytic infiltrates of the periportal areas of the liver the SP and lymphnodes meninges were infiltered by macrophages with ingested erythrocytes differential diagnosis includes an infection with leptospira icterohemorrhagica weils disease and erythrophagocytosis observed T3 various viral infections also histiocytosis x or malignant histiocytosis has to be taken into consideration the most probable diagnosis in our patient is that of familiar hemophagocytic reticulosis although the familiarity in our patient was lacking intra vitam diagnosis can only be established by liver biopsy which could not be performed in our patient due to the severe coagulation disturbance | MEDAL |
the value of gallbladder thickening in predicting the presence of acute cholecystitis was assessed by reviewing gallbladder sonograms for normal patients fasting normal patients patients with proven AC patients with ascites or an alcoholic history and patients with surgically proven chronic cholecystitis and gallstones thickened gallbladder walls were found in all patients with ascites percent of patients with AC and approximately percent of those with chronic cholecystitis the finding of GB wall thickening is suggestive evidence of AC but it is not a pathognomonic finding | MEDAL |
various aspects of particlestabilized emulsions or socalled pickering emulsions have been extensively investigated during the last two decades but the preparation of uniform pickering w/o/w droplets via a simple and scalable method has been sparingly realized we report the preparation of uniform pickering emulsions by shirasu porous glass spg membrane emulsification the size of the emulsion droplets ranging from μm can be precisely controlled by the size of the membrane pore the w/o/w droplets have a high monodispersity with coefficients of variation cv lower than in all of the investigated systems we further demonstrate the feasibility of locking the assembled particles at the interface and emulsion droplets have been shown to be excellent templates for the preparation of monodisperse colloidosomes that are necessary in drugdelivery systems | MEDAL |
after thinking about the past and imagining the future how do people separate these real and imagined events in memory we had subjects engage in past and future autobiographical elaboration then later take memory tests that required them to recollect these earlier generated events in experiment testing memory for previously generated past or future autobiographical events led to fewer source SM confusions than did an elaborative control task suggesting that the distinctive features of autobiographical elaboration improved subsequent retrieval monitoring accuracy in experiment we directly compared retrieval monitoring accuracy for previously generated past and future autobiographical events and found that subjects made fewer source confusions when searching memory for future events this asymmetry suggests that the features characterizing future elaborations eg cognitive operations were used more effectively during reality monitoring than were the features characterizing past elaborations eg perceptual details and has implications for futureoriented theories of memory | MEDAL |
microrheology is a technique that is increasingly used to investigate the local viscoelastic properties of complex fluids noninvasively by tracking the motion of micronsized probe spheres in this work passive particle tracking microrheology ptm is used to study network formation in the milk protein betalactoglobulin at degrees c and ph in these conditions the protein aggregates to form threadlike structures known as amyloid fibrils which can further aggregate into elastic networks using ptm gels were observed to form at significantly lower concentrations than determined by bulk rheometry where the oscillatory shear forces may disrupt either fibril or network formation during incubation the mean square displacement msd of the probe particles exhibited timecure superposition allowing the critical relaxation exponent to be calculated as approximately consistent with other biopolymer gels combined with the gellike appearance of the complex modulus at long incubation times this confirms that a true gel is forming with physical or chemical crosslinks forming between the fibrils refining the conclusions of other workers in the field | MEDAL |
introductionthe flux of ions across membranes via SAC is vital to cellular responses to internal and external stimuli and therefore to cellular survival in changing circumstances patch clamping is a powerful technique for ion channel investigation because it enables measurement of both net ion fluxes across the entire SA of a cell and ion currents flowing through a single open channel however unlike animal cells plant cells are surrounded by cell walls that prevent the physical contact between the patch pipette and the plasma membrane necessary for the patch clamp technique to demonstrate how patch clamping can be applied to plant physiology research we describe a protocol used to record potassium ion k channel currents in arabidopsis guard cell protoplasts a widely studied MM cell type in plant biology the protocol requires a twostep cellulase and pectinase digestion to isolate high SQ arabidopsis guard cell protoplasts ie plant cells lacking their PCW preparation of suitar pyrosequencing tags these represent all major and many minor protistan taxa at frequencies globally similar between the two sequence collections this large data set provided via the recently developed parametric modeling the first statistically sound prediction of the total size of protistan richness in a C1 and varied environment such as the cariaco basin over species defined as almost FL s rrna gene sequence clusters sharing over CS homology this richness is a small fraction of the grand total of known protists over species suggesting a degree of protistan endemism | MEDAL |
the outcome of laminectomy for the relief of PS resulting from degenerative lumbar stenosis is not well established eightyeight consecutive patients who had had a laminectomy for degenerative lumbar stenosis between and were studied eight of the patients had had a concomitant arthrodesis the followup DUE included a review of charts and standardized questionnaires that were completed by the patients one year postoperatively five patients per cent had had a second operation and five still had severe pain by the time of the latest followup in fifteen per cent of the original eightyeight patients had had a repeat operation because of instability or stenosis twentyone per cent of the seventy patients who were evaluated by questionnaire in had severe pain the factors found to be associated with a poor LT outcome defined as severe pain or the need for a repeat operation or both included coexisting illnesses such as osteoarthrosis cardiac disease RA ICA or chronic pulmonary disease p the duration of followup p and an initial laminectomy involving a single interspace p we concluded that the LT outcome of decompressive laminectomy is less favorable than has been previously reported and that comorbidity and a singleinterspace laminectomy are risk factors for a poor outcome | MEDAL |
bile leakage is a serious postoperative complication and percutaneous transhepatic biliary drainage ptbd may be an option when endoscopic treatment is not feasible in this retrospective T0 we established technical and clinical success rates as well as the complication rates of ptbd in a large group of patients with postoperative bile leakage | MEDAL |
in this T0 we reported the application of povacoat® a hydrophilic polyvinylalcohol copolymer as a dispersion stabilizer of NPs of poorly watersoluble compounds in addition the influence of aggregation of the nanoparticles on their solubility and oral absorption was studied griseofulvin gf was used as a model compound with poor water solubility and was milled to NPs by wet bead milling the dispersion stability of gf milled with povacoat® or the generally used polymers PVA hydroxypropylcellulose ssl and polyvinylpyrrolidone k was compared milled gf suspended in povacoat® aqueous solution with dmannitol added to improve the disintegration rate of freezedried gf exhibited high dispersion stability without aggregation d ca μm whereas milled gf suspended in aqueous solutions of the other polymers aggregated d μm milled gf with povacoat® showed improved aqueous solubility and bioavailability compared with the other polymers the aggregation of NPs had significant impact on the solubility and BA of gf povacoat® also prevented the aggregation of the various milled poorly watersoluble EDC hydrochlorothiazide and tolbutamide etc more effectively than the other polymers these results showed that povacoat® could have wide applicability to the OD of nanoformulations of poorly watersoluble EDC | MEDAL |
few physicians are familiar with EM plasmacytoma emp invasion of the spinal canal in multiple myeloma mm patients and little information about this rare disease is available the purpose of the present study was to investigate the clinical features prognosis and treatment of mm patients with emp invasion of the spinal canal we evaluated mm patients with emp invasion of the spinal canal emp invasion was confirmed by magnetic resonance imaging computed tomography andor histopathological analysis of bone marrow biopsy samples patients underwent surgery followed by chemotherapy or received chemotherapy CT chemotherapy consisted of bortezomibcontaining regimens and other combination therapies the patients median age was years range years eight patients had negative immunofixation PACE results and nine patients had a bone marrow plasma cell infiltration rate of less than of the mm patients with emp invasion of the spinal canal that we identified had thoracic spinal cord involvement had lumbar spinal cord involvement had S3 spinal cord involvement and had both lumbar and thoracic spinal cord involvement the findings of our study which is the largest study in mm patients with emp spinal canal invasion conducted to date suggest the importance of the early detection of spinal invasion in mm patients EM disease was resistant to conventional treatments but responded well to regimens containing novel drugs such as bortezomib in patients with PS of nerve root involvement the tumour should be resected as soon as possible to relieve SCC | MEDAL |
the neonatal changes in the plasma concentration thyrotropin t t and cortisol were followed in six lambs born days before term after injection of oestrogen into the ewes and in six FT animals the plasma t concentrations were significantly lower in the PT animals h h h h days days days and days T3 birth the plasma t concentrations were significantly higher in the PT lambs than in the controls during the first h of life the tt ratios were constantly lower in the PT animals during the first days of life the plasma cortisol concentrations were significantly lower in the PT lambs over the first h of life in contrast to the FT animals the thyroid of the PT ones did not respond to an increase in the plasma concentration of TSH by a rise in the plasma concentration of the iodinated hormones thyroid CF seems affected by prematurity during the first month of life the t to t conversion may be impaired and the plasma t concentration is depressed since the thyroid seemed to be relatively insensitive to a TSH surge induced for instance by cold thermoregulation could be impaired in PT lambs the low concentration of t and cortisol observed at birth may also contribute to a reduction in the synthesis of the pulmonary SF these results can therefore at least in part explain the high mortality rate observed in premature mammals | MEDAL |
the performance of the aermod air dispersion model under low wind speed conditions especially for applications with only one level of meteorological data and no direct turbulence measurements or vertical temperature gradient observations is the focus of this study the analysis documented in this paper addresses evaluations for low wind conditions involving tall stack releases for which multiple years of concurrent emissions meteorological data and monitoring data are available aermod was tested on two fieldstudy databases involving several so monitors and hourly emissions data that had subhourly meteorological data eg min averages available using several technical options default mode with various low wind speed beta options and using the available subhourly meteorological data these field T0 databases included mercer county a north dakota database featuring five so monitors within km of the dakota gasification companys plant and the antelope valley station SP plant in an area of both flat and elevated terrain and a flatterrain setting database with four so monitors within km of the gibson generating station in southwest indiana both CS featured regionally representative m meteorological databases with no significant terrain obstacles between the meteorological site and the emission sources the low wind beta options show improvement in MM performance helping to reduce some of the overprediction biases currently present in aermod when run with regulatory default options the overall findings with the low wind speed testing on these tall stack fieldstudy databases indicate that aermod low wiovert control had children whose level of food neophobia also increased p mothers who used more covert control had children with better quality diets at both time points p and mothers who increased their use of covert control over the two year followup had children whose diet SQ improved p these associations were independent of confounders such as mothers level of education in the focus groups mothers suggested that FF young children was stressful and that control was often relinquished in order to reduce conflict at mealtimes supporting parents to adopt more covert techniques to control their childrens eating habits may be an effective way of improving the quality of young childrens diets | MEDAL |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.