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Map Adverse Drug Events (ADEs) mentioned in text data to their most relevant Preferred MeDDRA terms.
We describe a continuous ambulatory peritoneal dialysis (CAPD) patient that developed vancomycin-induced agranulocytosis during treatment for methicillin-resistant Staphylococcus aureus (MRSA)-associated external cuff infection and pneumonia.
Agranulocytosis
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It is very likely that the dexamethasone used in the antiemetic drug regimen contributed to the development of osteonecrosis in these patients.
Osteonecrosis
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Osteonecrosis is a serious side effect of antiemetic treatment with dexamethasone and this serious complication should be incorporated in the current guidelines.
Osteonecrosis
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Patients should be informed about the risk of osteonecrosis when taking dexamethasone as an antiemetic drug.
Osteonecrosis
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Development of Peyronie's disease during long-term colchicine treatment.
Peyronie's disease
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However here we reported two patients, presenting with PD during high dose colchicine treatment for familiar mediterranean fever (FMF).
Peyronie's disease
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A patient developed cholestatic hepatitis while being treated with nitrofurantoin.
Hepatitis cholestatic
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A second episode of jaundice followed the intravaginal administration of a mixture of furazolidone and nifuroxime.
Jaundice
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We report a case of unintentional overdose of oral pilocarpine tablets that resulted in bradycardia, mild hypotension, and muscarinic symptoms in a patient with Sjogren's syndrome.
Bradycardia
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Although combinations of belladonna, ergotamine, and phenobarbital have been used for medical treatment of menopausal symptoms since the 1960s, this is the first known case report of its association with anticonvulsant hypersensitivity syndrome.
Drug reaction with Eosinophilia and systemic symptoms
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Anticonvulsant hypersensitivity syndrome associated with Bellamine S, a therapy for menopausal symptoms.
Drug reaction with Eosinophilia and systemic symptoms
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We report a case of a previously healthy, postmenopausal woman who developed anticonvulsant hypersensitivity syndrome while taking Bellamine S (belladonna alkaloids; ergotamine; phenobarbital) for hot flashes.
Drug reaction with Eosinophilia and systemic symptoms
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A case of heatstroke is reported in a 32-year-old man diagnosed with schizophrenia and on clozapine monotherapy.
Cerebrovascular accident
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Heat stroke in schizophrenia during clozapine treatment: rapid recognition and management.
Cerebrovascular accident
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Gemcitabine-related radiation recall preferentially involves internal tissue and organs.
Recall phenomenon
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The authors also determined that their case of myositis developing in the rectus abdominus muscle of a patient with pancreatic adenocarcinoma was the manifestation of radiation recall, thereby bringing the number of patients who developed radiation recall to gemcitabine and were discussed in the current study to 13.
Myositis
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The literature search found 12 cases of radiation recall caused by gemcitabine.
Recall phenomenon
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The majority of radiation recall reactions attributed to gemcitabine are reported to affect internal tissue or organs.
Recall phenomenon
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Cystoid macular edema in a low-risk patient after switching from latanoprost to bimatoprost.
Cystoid macular oOedema
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METHODS: A 68-year-old man developed intense conjunctival hyperemia and cystoid macula edema after switching from latanoprost to bimatoprost 9 months after cataract surgery in an eye at low-risk for this cystoid macular edema.
Cystoid macular oOedema
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PURPOSE: To report a case of angiographically documented cystoid macula edema occurring after switching a pseudophakic patient from latanoprost to bimatoprost.
Cystoid macular oOedema
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An immediate hemolytic reaction induced by repeated administration of oxaliplatin.
Haemolysis
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CASE REPORT: We report a patient who developed a DAT-positive hemolytic episode after a red cell (RBC) transfusion was delivered during the infusion of her 17th cycle of oxaliplatin.
Haemolytic Anaemia
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Although neurotoxicity is a frequent complication of methotrexate therapy, fatal acute neurotoxicity is extremely uncommon, especially in adults.
Neurotoxicity
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Clinicians should be aware of the signs and symptoms of neurotoxicity during treatment, as well as predisposing factors that put patients receiving methotrexate at risk for neurotoxic effects.
Neurotoxicity
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Fatal acute encephalomyelitis after a single dose of intrathecal methotrexate.
Acute disseminated encephalomyelitis
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The day after methotrexate administration, the patient complained of severe back pain and urinary retention.
Back pain
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This patient rapidly progressed from mild neurotoxicity to fatal encephalopathy after one dose of intrathecal methotrexate during his third cycle of chemotherapy.
Encephalopathy
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We report a third case of a 6-week-old infant with Escherichia coli sepsis who received ampicillin and other antibiotics and subsequently developed TEN.
Toxic epidermal necrolysis
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One patient developed large intramural esophageal hematoma as a complication of heparin therapy.
Oesophageal intramural haematoma
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Eosinophilic cystitis after bladder instillation with dimethyl sulfoxide.
Eosinophilic cystitis
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We report the first case of an acute flare of eosinophilic cystitis in a 51-year-old woman after bladder instillation with dimethyl sulfoxide (DMSO) for presumed interstitial cystitis.
Eosinophilic cystitis
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Acute dystonia during pegylated interferon alpha therapy in a case with chronic hepatitis B infection.
Dystonia
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In this case report, we present clinical and laboratory findings of a case with chronic hepatitis B that developed acute dystonia soon after the first dose of pegylated interferon alpha.
Dystonia
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Therapy with IFN-alpha may be associated with a number of neuropsychiatric symptoms, such as Parkinsonism, akathisia, seizure, and depressive disorders.
Akathisia
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A patient developed restless legs symptoms paralleling the course of interferon-alpha (IFN alpha) therapy for chronic hepatitis C.
Restless legs syndrome
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Restless legs syndrome due to interferon-alpha.
Restless legs syndrome
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Restless legs syndrome may thus be an adverse effect of IFN alpha treatment.
Restless legs syndrome
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Many clinicians appear to be concerned about the potential hepatotoxicity of the opiate antagonist naltrexone (NTX) and this may be one reason why it is not used more widely in treating both heroin and alcohol abusers.
Hepatotoxicity
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We describe a heroin abuser in whom clinical and laboratory manifestations of acute hepatitis B and C appeared a few days after the insertion of a subcutaneous naltrexone implant.
Hepatic necrosis
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Sweet's syndrome associated with sargramostim (granulocyte-macrophage colony stimulating factor) treatment.
Acute febrile neutrophilic dermatosis
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Sweet's syndrome is an acute febrile neutrophilic dermatosis that is a known complication of the administration of filgrastim, a drug that causes increased neutrophil proliferation and differentiation.
Acute febrile neutrophilic dermatosis
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We report a case of Sweet's syndrome in association with sargramostim treatment following chemotherapy for acute myelogenous leukemia.
Acute febrile neutrophilic dermatosis
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Sudden cardiac death due to hypersensitivity myocarditis during clozapine treatment.
Hypersensitivity myocarditis
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The autopsy findings and a detailed medical history supported the conclusion that clozapine-induced hypersensitivity myocarditis was the most likely cause of death.
Hypersensitivity myocarditis
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The case concerns the sudden death of a 29-year-old male during clozapine therapy started 2 weeks before.
Sudden Death
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Purple glove syndrome, named for its distinctive purple discoloration and swelling of the hands in the distribution of a glove, is an uncommon complication of intravenous phenytoin administration through small dorsal veins of the hands.
Purpura
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The findings were judged to be consistent with soft-tissue injury associated with intravenous administration of phenytoin, also termed purple glove syndrome.
Purple glove syndrome
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Our patient was a 72-year-old man with advanced Parkinson's disease (PD) who received levodopa and anti-cholinergic drugs and whose head had become almost completely bald.
Alopecia totalis
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A patient with monocular open-angle glaucoma had trichiasis, a condition associated with the use of a prostaglandin analog.
Trichiasis
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Increased lash length, thickness, and pigmentation are well-documented side effects of prostaglandin analog glaucoma drops.
Eyelash changes
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Trichiasis associated with prostaglandin analog use.
Trichiasis
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Fatal pulmonary fibrosis associated with BCNU: the relative role of platelet-derived growth factor-B, insulin-like growth factor I, transforming growth factor-beta1 and cyclooxygenase-2.
Pulmonary fibrosis
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Pulmonary fibrosis is a severe complication associated with bis-chloronitrosourea (BCNU) therapy.
Pulmonary fibrosis
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These novel findings may offer specific therapeutic targets in the treatment of BCNU-associated pulmonary fibrosis.
Pulmonary fibrosis
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We further used immunohistochemistry (IHC) to examine the relative role of platelet-derived growth factor-B (PDGF-B), insulin-like growth factor I (IGF-I), transforming growth factor-beta1 (TGF-beta1) and cyclooxygenase-2 (COX-2) in the pathogenesis of BCNU-related pulmonary fibrosis.
Pulmonary fibrosis
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We report here a 26-year-old female with diffuse large B-cell lymphoma who died of severe pulmonary fibrosis 81 days after the administration of high-dose BCNU (600 mg/m2).
Pulmonary fibrosis
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Dorzolamide-induced choroidal detachment in a surgically untreated eye.
Choroidal detachment
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METHODS: A 76-year-old woman with primary open-angle glaucoma and no history of ocular surgery developed a choroidal detachment 12 hours after initiation of therapy with dorzolamide eye drops.
Choroidal detachment
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We document the abrupt development of an extensive choroidal detachment after initiation of dorzolamide therapy in a surgically untreated eye with primary open-angle glaucoma.
Choroidal detachment
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Deepening of lid sulcus from topical bimatoprost therapy.
Periorbital fat atrophy
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In each of the three reported patients, alteration of eyelid appearance with deepening of the lid sulcus was evident as the result of topical bimatoprost therapy.
Eyelid vellus hair changes
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Lichen planus induced by hepatitis B vaccination: a new case and review of the literature.
Lichen planus
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Case report: life-threatening hypoglycaemia associated with sulfadoxine-pyrimethamine, a commonly used antimalarial drug.
Hypoglycaemia
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In this report, we present a case of hypoglycaemic coma associated with SP, an adverse reaction that is likely to be underreported and expected to occur with greater frequency as the use of SP increases.
Hypoglycaemic coma
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Initial treatment with heparin was substituted with thrombolysis, which resulted in clinical improvement and dissolution of right heart thrombus but was followed by fatal intracerebral haemorrhage.
Cerebral Haemorrhage
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Extensive forearm deep venous thrombosis following a severe infliximab infusion reaction.
Deep vein Thrombosis
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Here we describe a patient with Crohn's disease who developed a severe infliximab infusion reaction (IIR), complicated 1 day later by severe swelling of the forearm and hand ipsilateral to the site of infliximab infusion.
Infusion related reaction
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The site of thrombosis and the chronological relationship with the IIR implicates a hypersensitivity to infliximab in the causation of the venous thrombosis in this case.
Hypersensitivity
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After 3- to 13-month period of therapy without indapamide, glucose levels of all patients decreased and diabetes disappeared.
Diabetes mellitus
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After stopping indapamide, glucose tolerance impairing may be reversed.
Glucose tolerance impaired
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CONCLUSION: Therapy with indapamide may induce diabetes in essential hypertension patients.
Diabetes mellitus
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OBJECTIVE: To study therapy with indapamide impairing carbohydrate metabolism in essential hypertension patients and achieve earlier prevention, diagnoses and treatment of diabetes induced by indapamide.
Diabetes mellitus
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Possible induction of diabetes by treatment of hypertension with indapamide (with four case reports).
Diabetes mellitus
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RESULTS: After 4- to 14-month period of therapy with the combination of indapamide (2.5 mg/day) and fosinopril (10 mg/day) in three patients and 6-month period of monotherapy with indapamide (2.5 mg/day) in one patient, glucose levels of all patients increased and achieve criteria of diabetes diagnoses.
Diabetes mellitus
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Despite a hematologic response in all 3 patients, none of them achieved cytogenetic remission, and all progressed to blast crisis at 7 to 10 months of imatinib therapy.
Blast cell crisis
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In addition to disease refractoriness, rare instances of disease progression from chronic phase to blast crisis during imatinib therapy have recently been anecdotally reported.
Blast cell crisis
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OBJECTIVES: To describe the clinicopathologic features of 3 patients with CML who rapidly progressed from chronic phase to blast crisis while taking imatinib and to perform a review of the literature.
Blast cell crisis
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Our findings suggest that significant progression of marrow reticulin fibrosis during imatinib therapy can be an indicator for a return or progression of CML and, in some patients with CML, imatinib may promote cytogenetic clonal evolution, resulting in a poor response to treatment.
Bone marrow reticulin fibrosis
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Progression of chronic myeloid leukemia to blast crisis during treatment with imatinib mesylate.
Blast cell crisis
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Easily reversible hypoxemia and hypotension induced by nimodipine.
Hypotension
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In this paper we report a case of nimodipine overdosage resulting in prolonged hypotension and hypoxemia, which was successfully treated with calcium gluconate.
Hypoxia
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Refractory hypoglycemia from ciprofloxacin and glyburide interaction.
Hypoglycaemia
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We present a case of a diabetic patient taking glyburide who was prescribed ciprofloxacin and developed prolonged hypoglycemia, which persisted for over 24 hours.
Hypoglycaemia
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Aminophylline hypersensitivity apparently due to ethylenediamine.
Drug hypersensitivity
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We present a case of ethylenediamine-induced delayed hypersensitivity reaction in a 46-year-old woman who received parenteral aminophylline for an acute asthma exacerbation.
Type IV hypersensitivity reaction
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L-asparaginase-induced severe necrotizing pancreatitis successfully treated with percutaneous drainage.
Pancreatitis necrotising
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Most cases of pancreatitis associated with L-asparaginase toxicity are self-limiting and respond favorably to nasogastric decompression and intravenous hyperalimentation.
Pancreatitis
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Pancreatitis has been noted to be a complication in 2-16% of patients undergoing treatment with L-asparaginase for a variety of pediatric neoplasms.
Pancreatitis
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We present a pediatric patient with leukemia and a severe, L-asparaginase-induced necrotizing pancreatitis, treated successfully with percutaneous drainage used to flush the infected necrotic parts.
Pancreatitis necrotising
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Disulfiram-induced fulminant hepatic failure in an active duty soldier.
Acute hepatic failure
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Fulminant hepatic failure is a rare complication of disulfiram treatment for alcoholism.
Acute hepatic failure
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This case describes fulminant hepatic failure in a patient taking disulfiram with no previous liver disease and report of being compliant with alcohol abstinence.
Acute hepatic failure
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Tiagabine overdose causes an unusual array of neurological symptoms, many similar to reported adverse effects during therapeutic use.
Neurological symptom
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A case of sideroblastic anemia is presented in a patient with a left ventricular assist device drive-line infection who was receiving linezolid, an antibiotic used for serious infections with gram-positive organisms.
Sideroblastic Anaemia
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As linezolid has been shown to have hematologic side effects, blood count monitoring is recommended in patients receiving this drug for long-term therapy.
hematologic side effects
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Sideroblastic anemia due to linezolid in a patient with a left ventricular assist device.
Sideroblastic Anaemia
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Acute renal insufficiency is known to occur in patients who are taking ciprofloxacin, particularly the elderly.
Acute kidney injury
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Ciprofloxacin-induced renal insufficiency in cystic fibrosis.
Renal failure
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Multiple mechanisms for ciprofloxacin-induced nephrotoxicity have been proposed.
Nephropathy toxic